Gene DDB_G0285449 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP006_AA protein Get Run
DdisP006_AA_585-729 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 586-729 1.4e-28 95.1 In-house 27-174 (178) alignment 
Range on Protein: 586-729
Range on HMM: 27-174/178.0
DPNinIFVGGKNCLNNLEWLEKENINSILNATIEVS------LPKSLEH--LKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNSPsSSILIHCKEGRSR
.|.  ...|. .. ..||.| ...|..|.| | |.       .|. .|   ...... ..|. .... ..| ...|||.. | ... . .|.||. |..|
lpg..lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgR

STTLAVAFGMKALKLSLKDSYEYVKNSAPrININTGFQFQLMEYEKSLYGYN
|.||..|. || |.||| . .|.|..  | |..| |.. ||.|.|. |....
sgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 589-725 8.7e-22 71.1 In-house 8-152 (154) alignment 
Range on Protein: 589-725
Range on HMM: 8-152/154.0
INIFVGGKNCLNNLEWLEKENINSILNA--TIEVSLPKS------LEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNSPSSSILIHCKEGRSRSTT
|.....  .   |   |.. ||.||||    |.  ...          ... .. . | ... | . .. | |||....     . .|.|...| |||..
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LAVAFGMKALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
|.... |. ||.||  ..| .|.| . |. |.||  ||  .|| |
llisylmdklkislslalellkdsryiikPnqGflkqleifekel
0045098 (Phosphotyrosine protein) phosphatases II 589-727 5.2e-19 64.2 In-house 27-273 (278) alignment 
Range on Protein: 589-727
Range on HMM: 27-273/278.0
INIFVGGKN-----------------------------------------CLNNLEWLEKENINSILNAT------------------------------
 ....|...                                         . .... | ...|..|...|                              
palylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtll

---------------------IEVSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLT------------NSPSSSILIHCKEGRSRSTTLAVA
                      |   .  ..||... .   .. ..|| ..| ...|||.. |             ....  .|.||. | .|. ||..|
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

FGMKAL---KLSLKDSYEYVKNSAPR-ININTGFQFQLMEYEKSLYG
. |. |   ...| . ......  |  .  | ... .|.|..  |. 
ylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_DSP8_pd Subfamily DSP8 590-725 1.4e-30 100.0 In-house 21-154 (159) alignment 
Range on Protein: 590-725
Range on HMM: 21-154/159.0
NIFVGGKNCLNNLEWLEKENINSILNATIEVSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMKA
|...| ..   . | |.| .|. .|||  .   .. |.. ||.|| | |..|  .  .|. ..|||..   .| ....|.|.  |.|||.|.|.|. || 
nlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidka..ksengrvlvhvlaGisrsatvaiayimkt

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
|..|| ..|..||.  | |. |  |. ||.||||.|
lemsldeayrfvkekrptispnlnflgqLleyekel
subfamily_DSP6_pd Subfamily DSP6 590-725 7.4e-30 97.5 In-house 20-154 (158) alignment 
Range on Protein: 590-725
Range on HMM: 20-154/158.0
NIFVGGKNCLNNLEWLEKENINSILNATIE-VSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMK
....| ..  .||| |.| .|. .|| | .  .  .. ..||. .....| . | . ..| .|||||... ..  .|..|.||  | ||| |...|. ||
llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk..kskvlvhClaGisrsvtvtlaylmk

ALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
 |.|||.|.|..||.  . |  |  |  ||...|.||
klalslndaydlvkkrksnisPnfnfmgqlldfersl
PTPc_motif_SM00404 590-723 3.2e-29 96.6 In-house 8-139 (140) alignment 
Range on Protein: 590-723
Range on HMM: 8-139/140.0
NIFVGGKNCLNNLEWLEKENINSILNATIEVSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMKA
....|.|.  .|.. |.| .|  ..|.| ||||.|. .. ..... ..|.  ... .|.. ...||...  ..   ..|.||. | ||| ||..|. |. 
hlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmry

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEK
 .|||...||.||. .|.|. |..| .||.||||
rqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP1_pd Subfamily DSP1 590-725 5.2e-27 88.9 In-house 24-156 (163) alignment 
Range on Protein: 590-725
Range on HMM: 24-156/163.0
NIFVGGKNCLNNLEWLEKENINSILNATIEVSLPkSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMKA
 ...|...   ||| |....|  |||.. |..     ..... .. ..|| .. |  .|...||||..   ..    .||||. | |||.|| .|. || 
fLylGsetvasnleiLkslgitailnvskeldnv.fedlfeYkklkleDspkadislvfeeviefidev..kkknGkvlihCqaGisRsstlclaylmkt

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
 ..||.. ...||.  . |. |.||. ||..|||.|
krvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
subfamily_DSP19_pd Subfamily DSP19 590-725 1.8e-26 87.3 In-house 18-150 (152) alignment 
Range on Protein: 590-725
Range on HMM: 18-150/152.0
NIFVGGKNCLNNLEWLEKENINSILNATIEVSLPkSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNSpsSSILIHCKEGRSRSTTLAVAFGMKA
....| ..  .. | |....|  ||| ...|      .....  ... |  .. . .|...|..||......     .|.||. |.|||.....|. || 
rlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkk

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
 .|||....|.|..  | |. |.||. || |||..|
eelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP15_pd Subfamily DSP15 590-724 1e-24 81.4 In-house 8-138 (151) alignment 
Range on Protein: 590-724
Range on HMM: 8-138/151.0
NIFVGGKNCLNNLEWLEKENINSILNatIEVSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKA
....|. .  .. | |...||  ||.  .. .  | |.....  ...||. .. ....|....||| ..  .    ..|.||  | |||.||.||. | .
glylgnfrdskdeelLkeknithils..vhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlk..eenvlvhClaGvsRsvtlvvaYlmtv

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKS
..|. .|. | .|..    | |.||. ||.||||.
telnwrdalevikaaRsvanPnfGfkrqlkeyekt
0048179 (Phosphotyrosine protein) phosphatases II 590-724 1.8e-24 81.5 In-house 10-143 (144) alignment 
Range on Protein: 590-724
Range on HMM: 10-143/144.0
NIFVGGKNCLNNLEWLEKENINSILNATIEvSLPKSLEHL--KFFRVSVSDSIDQPINRYFNDAIEFIQQSLTnsPSSSILIHCKEGRSRSTTLAVAFGM
....|.  ....||.| | .|. ..| | |   | .||.   ....... |    ..  ......|||.. |   ..  .|.||. |..|..||..|. |
glylgslptaldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylm

KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKS
| |.|||.. ...|..  | ...| |.  .|.|||| 
kklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 590-726 2.5e-24 81.0 In-house 10-143 (145) alignment 
Range on Protein: 590-726
Range on HMM: 10-143/145.0
NIFVGGKNCLNNLEWLEKENINSILNATIEVSLPKsLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNSpsSSILIHCKEGRSRSTTLAVAFGMKA
....|.  . ..||.|.. .|  .|| | | .|..  .......... |   ... ... ...|||.. | .     .|.||. |..|..||..|. |. 
glylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLY
|..|| . .|.|..  | ...| |.. .|.|.|. |.
lgvsleealelvrsqrpgavpnpgqlrflyefelell
subfamily_DSP12_pd Subfamily DSP12 590-727 1.8e-23 77.7 In-house 8-145 (155) alignment 
Range on Protein: 590-727
Range on HMM: 8-145/155.0
NIFVGGKNCLNNLEWLEKENINSILNATIEVS--LPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLtnSPSSSILIHCKEGRSRSTTLAVAFGM
....|| . ... | |.. .|...|  . |      ..  ...   . . |. ...| .....|..||...|  .   ..|.||. | ||| |. .|. |
glylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiviAYlm

KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYG
|  ||||.. .. ||.  |.|. |.||. ||  .||. . 
kkeklslekAlklvkekkpeiepNegFleQLklfekmgck
subfamily_LRR-DSP_pd Subfamily LRR-DSP 590-727 1.1e-22 74.4 In-house 126-260 (263) alignment 
Range on Protein: 590-727
Range on HMM: 126-260/263.0
NIFVGGKNCLNNLEWLEKENINSILNATIEvSLPKSLEHLKFFRV-SVSDSIDQPINRYFNDAIEFIQQSLTnspSSSILIHCKEGRSRSTTLAVAFGMK
..|.||... ||  .|.. ..  || |  .   |   . .|.. .  . |  .  | ..|..   ||..      .  .|.||. | |||.|| ... ||
klflGgldsannksilkdlgvthillavad.fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrk...kGGvlvhcraGvsrsstlvisylmk

ALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYG
  .| .|.... |..  |||. |.||. ||. ||| |. 
kqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
0043147 (Phosphotyrosine protein) phosphatases II 590-727 4e-22 74.2 In-house 25-162 (172) alignment 
Range on Protein: 590-727
Range on HMM: 25-162/172.0
NIFVGGKNCLNNLEWLEKENINSILNATiEV---SLPKSLEHLKFFRVSVSDSIDQpINRYFNDAIEFIQQSLTNSPSSSILIHCKEGRSRSTTLAVAFG
. .... ..  ... | ...|. |.|.| |      . . . ... .... |   . . ... ...|||.. | .||.  .|.||. | .|. ||..|. 
tqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MKaLKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYG
|. |.||| . ...|..  | .  | ... .|...|| |. 
ml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
subfamily_DSP3_pd Subfamily DSP3 590-725 4.3e-22 72.5 In-house 17-157 (162) alignment 
Range on Protein: 590-725
Range on HMM: 17-157/162.0
NIFVGGKNCLNNLEWLEKENINSILNATIE----VSLPKSL-E--HLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNsPSSSILIHCKEGRSRSTTLA
...||...  .. . |.|  |  .|||.      |   ..  .  ..|.. . |.|.    ...||. | .||...|.. ... .|.||..| |||.||.
klyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq.kegkvlvhcvvGvsRsatlv

VAFGMKALKLSLKDSYEYVKNSApRININTGFQFQLMEYEKSL
.|. |   |..|..  . |..   .|  |.||  ||.|....|
layLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel
0041856 (Phosphotyrosine protein) phosphatases II 590-729 2e-21 71.9 In-house 25-176 (182) alignment 
Range on Protein: 590-729
Range on HMM: 25-176/182.0
NIFVGGKNC--------------LNNLEWLEKENINSILNATIEVSLPKSLEH--LKFFRVSVSDSIDQPinryFNDAIEFIQQSLTnsPSSSILIHCKE
|...|.                  ..|..| ...|..|.|.| |   |. ||.  ........ |    .    ......||.. |   ..  .|.||. 
nlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle..eggpvlVHCsa

GRSRSTTLAVAFGMKALKLSLKDSYEYVKNSAP--RININTGFQFQLMEYEKSLYGYN
|..|. ||..|. || |..|| . ...|..  |   |. | .|  ||...|. |....
GvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_DSP10_pd Subfamily DSP10 591-726 1.7e-31 103.2 In-house 21-154 (159) alignment 
Range on Protein: 591-726
Range on HMM: 21-154/159.0
IFVGGKNCLNNLEWLEKENINSILNATIEVSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMKAL
.|.| ..  ..|. |.. ||. .|| | .|    . |.||. |. |||.  | ...||..|.|||..   .. .|..|.||. | |||.|...|. || |
LflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieea..rkkgsrvLvhCqaGisrsatvviaYlmkhl

KLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLY
.|||.|.|..||.  | |  | .|  ||.|.||.| 
nlslndaykfvkekrpiisPnLnfmGqLlefekeln
DSPc Dual specificity phosphatase, catalytic domain 591-723 5.3e-29 95.8 Pfam-A 1-132 (133) alignment 
Range on Protein: 591-723
Range on HMM: 1-132/133.0
IFVGGKNCLNnLEWLEKENINSILNATIEVSLP--KSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMK
...|.|.. . |. ||| .|. ..|.| ||. .  .. .. ...|. | |. .. | .....|.|||..    .   ..|.||. | ||| ||..|. ||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmk

ALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEK
  .|||.. ||.||. ...|. |.||..||.|||.
tknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 591-723 5.3e-29 95.8 In-house 1-132 (133) alignment 
Range on Protein: 591-723
Range on HMM: 1-132/133.0
IFVGGKNCLNnLEWLEKENINSILNATIEVSLP--KSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMK
...|.|.. . |. ||| .|. ..|.| ||. .  .. .. ...|. | |. .. | .....|.|||..    .   ..|.||. | ||| ||..|. ||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmk

ALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEK
  .|||.. ||.||. ...|. |.||..||.|||.
tknlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP14_pd Subfamily DSP14 591-734 6.8e-29 94.8 In-house 14-153 (157) alignment 
Range on Protein: 591-734
Range on HMM: 14-153/157.0
IFVGGKNCLNNlEWLEKENINSILNATIEVSLpKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSltNSPSSSILIHCKEGRSRSTTLAVAFGMKAL
.|..|  .|.. | |.|..|. |.|.|.|..  ..|....  .| |.|. .. . ..|. ... |..   .     .|.||. |.||| .|..|. ||  
Lflsgvaalsk.ellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieev..kkkggktlvhCvaGvSRSAslclaylmkye

KLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYGYNSFNLL
||||...|..||.  | |. |.||  ||..||| |.| .| ...
klsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmv
subfamily_Slingshot_pd Subfamily Slingshot 591-725 7.3e-24 78.0 In-house 26-157 (169) alignment 
Range on Protein: 591-725
Range on HMM: 26-157/169.0
IFVGGKNCLNNLEWLEKENINSILNATIEVSLpKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKAL
...|      ||| |...... ||| | |.      |........| |. .. . .|.|.. .||... ..   |..|.||| | |||..  .|. ||. 
vylGsewnasnleelkengveyilnvtkeidn.ffpekfeylnirvydeeetdllkywnetykfiekakkk..gskvlvhckmGvsrsastviayamkey

KLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
.|||....||||.    |. |.||  || |||  |
glsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 591-723 6.2e-22 71.7 In-house 15-145 (148) alignment 
Range on Protein: 591-723
Range on HMM: 15-145/148.0
IFVGGKNCLNNLEWLEKENINSILNATIEVSLPKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKAL
.|.| |.   .|| |.. ..  | ||| |   .     .... |...|  .. .. .|.|.|.|...   .     .|.|.. |.|||. ||... ..  
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakde..GrrvLvhlqmGvsrssalallwlidfk

KLSLKDSYEYVKNSAPRININTGFQFQLMEYEK
. |||. ...||.  . .. | ||  || |.|.
rvslkealalvkskrryvdpnlgfLkqLaeleq
0049260 (Phosphotyrosine protein) phosphatases II 591-725 9.8e-20 66.2 In-house 15-149 (152) alignment 
Range on Protein: 591-725
Range on HMM: 15-149/152.0
IFVGGKNCLNNLEWLEKENINSILNATIEVSLP--KSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSlTNSPSSSILIHCKEGRSRSTTLAVAFGMK
...|. .. .....| . .|. |.. | .. |.  |  .. ..... . |.  ...  .. ....||..    ...  .|.||. | .|. ||..|. |.
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml

aLKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
 |..||.. ...|..  | ...| |. ..|.|.|| |
.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0046846 (Phosphotyrosine protein) phosphatases II 591-725 8.1e-17 57.0 In-house 19-172 (176) alignment 
Range on Protein: 591-725
Range on HMM: 19-172/176.0
IFVGGK----------NCLNNLEWLEKENINSILNATIEV--------SLPKSL--EHLKFFRVSVSDSIDQPInRYFNDAIEFIQQSLTNSpsSSILIH
...|..          .. ..||.| ...|. ..| | ||         ... |  ........ . |    .. ... ...|||.. |..     .|.|
lilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVH

CKEGRSRSTTLAVAFGMKA-LKLSLKDSYEYVKNSAP-RININTGFQFQLMEYEKSL
|. |..|. ||..|. ..    ||. . ...|..  | ..  . ..  .|.|.|. |
CsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0051082 (Phosphotyrosine protein) phosphatases II 591-722 8.7e-17 56.6 In-house 15-150 (151) alignment 
Range on Protein: 591-722
Range on HMM: 15-150/151.0
IFVGGKNCLNNLEWLEKENINSILNATIEV---SLPKSLEH--LKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTnSPSSSILIHCKEGRSRSTTLAVAF
....|     .||.|....|..|.| . |.    .|. |.   ...... . |  |...  .|. ..||... |   ..  .|.||. |..|. ||....
lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvaly

GMKaLKLSLKDSYEYVKNSAP-RININTGFQFQLMEYE
 |. |..|| . .|... . |  .. |..|.|||....
lml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_MKPLT_pd Subfamily MKPLT 592-727 5.8e-17 55.7 In-house 30-162 (164) alignment 
Range on Protein: 592-727
Range on HMM: 30-162/164.0
FVGGKNCLNNLEWLEKENINSILNATIEVS--LPKSLEhlkFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKA
. |  .  .| . |.. .|. |.| . |     |||.|   . .|.|.|  |. .  ... | .|. ... .     .|.||  |.|||.. .||| .| 
ylGnakhatnekvlkdlkithivnvsqekkdafpksve...Ylqvkvedesdeqlssfleraakfladaids..GGrvlvhcvqGksrsssvtvafLiks

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYG
 .  ||..|||.|.    .. | ||  || ..|. ..|
kgwtlkeayeylkerrsivapnrGflkqlakfeelilG
subfamily_MKPLV_pd Subfamily MKPLV 592-727 5.8e-17 55.7 In-house 30-162 (164) alignment 
Range on Protein: 592-727
Range on HMM: 30-162/164.0
FVGGKNCLNNLEWLEKENINSILNATIEVS--LPKSLEhlkFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKA
. |  .  .| . |.. .|. |.| . |     |||.|   . .|.|.|  |. .  ... | .|. ... .     .|.||  |.|||.. .||| .| 
ylGnakhatnekvlkdlkithivnvsqekkdafpksve...Ylqvkvedesdeqlssfleraakfladaids..GGrvlvhcvqGksrsssvtvafLiks

LKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYG
 .  ||..|||.|.    .. | ||  || ..|. ..|
kgwtlkeayeylkerrsivapnrGflkqlakfeelilG
0036282 (Phosphotyrosine protein) phosphatases II 593-725 3.8e-18 61.2 In-house 20-169 (174) alignment 
Range on Protein: 593-725
Range on HMM: 20-169/174.0
VGGKNCLNNLEWLEKENINSILNATIEVSLP--------------KSLEHLKFFRVSVSDSIDQPINRyFNDAIEFIQQSLTNSPSSSILIHCKEGRSRS
. |. .|...|.| ...|..... . |. |                . ........ . |    ...  . ....|... | ..|.  .|.||. |..|.
iagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRt

TTLAVAFGMKALKL-SLKDSYEYVKNSA---PRININTGFQFQLMEYEKSL
 ||..|. |. ..| || | ...|.      |.. .. ..  .| ..|| |
GtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0049772 (Phosphotyrosine protein) phosphatases II 595-731 1.3e-24 82.9 In-house 156-279 (314) alignment 
Range on Protein: 595-731
Range on HMM: 156-279/314.0
GKNCLNNLEWLEkeninsilnatIEVSLPKSLEH--LKFFRVSVSDsIDQPINRYFNDAIEFIQQSltnSPSSSILIHCKEGRSRSTT-LAVAFGMKALK
.  .  .||.|.            |.  |. .|.  .|..|. |.|  ..|. ..|....|||..    .. . .|.||| |..|..| ...|. ||.|.
neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg

LSLKDSYEYVKNSAPrININTGFQFQLMEYEKSLYGYNSF
.||.. .|.|..  | ||.| ||  ||..||. |. .. .
vsleealedvrlkRp.inpnpgfieqleqyefilealley
0037934 (Phosphotyrosine protein) phosphatases II 598-725 4.1e-16 54.7 In-house 61-241 (243) alignment 
Range on Protein: 598-725
Range on HMM: 61-241/243.0
CLNNLEWLEKENINSILNATIEV--------------------------------------------SLPKSLEHLKFFRVSVSD----SIDQPINRYFN
  .... | ...|..|.. | .|                                              . .... .. .... |    .  ... ....
lasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfld

DAIEFIQQ---SLTNSPSSSILIHCKEGRSRSTTLAVAFGMKAL-KLSLKDSYEYVKNSAPR-ININTGFQFQLMEYEKSL
...|||..    |...... .|.||. |..|. ||..|. |. | ...| . ......  |  .  . ..  .|.|... |
evrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 599-725 8.5e-16 53.6 In-house 62-242 (245) alignment 
Range on Protein: 599-725
Range on HMM: 62-242/245.0
LNNLE----WLEKENINSILNATIEV---------------------------------------------SLPKSLEHLKFFRVSVSDSIDQPINRYFN
 ...|    .| ...|..|.. | |.                                               ..|.|.. ...... |    .. ... 
petvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllelll

DAIEFIQQSLTNSPSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
|..||... | ....  .|.||. |..|. |...|. |     | |..|| . ......  | .  . ..  .|.|... |
dflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 599-725 1.7e-14 49.5 In-house 68-245 (249) alignment 
Range on Protein: 599-725
Range on HMM: 68-245/249.0
LNNLEWLEKENINSILNATIEVSLP------------------------------------------KSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQ
 .....| ...|..|...| .| |                                           .  |...   . . |  |. .  .|.|...||.
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

QSLTNS----PSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
. ..      ... .|.||. | .|. |...|. |     | |...|.. ......  | .  | ..  .|.|... |
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
PTEN_1 600-725 2.6e-21 71.3 In-house 58-191 (196) alignment 
Range on Protein: 600-725
Range on HMM: 58-191/196.0
NNLEWLEKENINSILNATIEVSL------PKSLE--HLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNSPSSSILIHCKEGRSRSTTLAVAFGMKALK
..|..|....| ...| . |  |      ... .  .... .... |   ..... |  . .||.. | ...   .|.||| |..|| |.. |. |.. |
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

LSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
|. ..  |.|.   |....|...| .|.||...|
ltadeAlelvrekRppgapnspsqerlleyfael
0051429 (Phosphotyrosine protein) phosphatases II 600-725 3e-11 39.0 In-house 36-224 (272) alignment 
Range on Protein: 600-725
Range on HMM: 36-224/272.0
NNLEWLEKENINSILNATIEVSL-----PKSLEHLKFFRVSVSDSIDQPIN-------------------------------------------------
.....|....|..|.. . |. .     .. ........... |. ...|.                                                 
adfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgv

--RYFNDAIEFIQQsltnspSSSILIHCKEGRSRSTTLAVAFGMKaLKLS--------------LKDSYEYVKNSAPRININTGFQFQLMEYEKSL
   .. ...|....      .  .|.||. |..|. |..... .  | .|              | . .|...   | .. . ..  .|.|... |
pqeallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
subfamily_STYX_pd Subfamily STYX 602-723 1.5e-15 50.6 In-house 32-155 (166) alignment 
Range on Protein: 602-723
Range on HMM: 32-155/166.0
LEWLEKENINSILN--ATIEVSL--PKSLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKALKLSLKDS
|| |.|. |  |.    .|| .|  |.  ...... . |.|.  . | ||.    |||..|| .     .|.| . | |||..| .|. |..  |  ...
levlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqk..ggkvlvhgnagisrsaalviayimetyglkyrea

YEYVKNSAPRININTGFQFQLMEYEK
. ||..    || | ||  ||.||| 
fayvqerrfcinpnegfvsqlkeyea
0045450 (Phosphotyrosine protein) phosphatases II 602-725 3.2e-14 48.8 In-house 124-303 (307) alignment 
Range on Protein: 602-725
Range on HMM: 124-303/307.0
LEWLEKENINSILNATIEVSLPK---------------------------SLEHLKFFRVSVSDS-----------------IDQPINRYFNDAIEFIQQ
...| ..... |.. | .| | .                            |.... ... |.|.                  |. .  .|.....||..
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

SLT----NSPSSSILIHCKEGRSRSTTLAVAFGMKALK--------LSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
 ..    ..... .|.||. | .|. |...|. |. .         ..| . ......  | .  | ..  .|.|... |
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 602-726 3.2e-13 45.1 In-house 103-276 (317) alignment 
Range on Protein: 602-726
Range on HMM: 103-276/317.0
LEWLEKENINSILNATIEVSLPK--------------------------SLEHLKFFRVSVSDS----------------IDQPINRYFNDAIEFIQQSL
.. . ......|.. | .. | .                           |.. . ... |.|.                 |. .  .... ..|...  
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

TN--SPSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLY
..  .|.. .|.||. | .|. |...|. |     |  ...... ......  | .  . ..  .|....  ..
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 604-727 7.3e-12 40.8 In-house 120-290 (297) alignment 
Range on Protein: 604-727
Range on HMM: 120-290/297.0
WLEKENINSILNATIEVSLPK-----------------------------------------SLEHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNS
 . ......|.. | .| | .                                         |...  |  ..  |    |. ... ...|.... | ..
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-PSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYG
 ..  .|.||. | .|. |...|. |     |  ...... ......  | .  . ..  .|..... |. 
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 605-723 1.8e-08 29.6 In-house 108-274 (278) alignment 
Range on Protein: 605-723
Range on HMM: 108-274/278.0
LEKENINSILNATIEV--------------------------------------------SLPKSLEHLKFFRVSVSdSIDQP-INRYFNDAIEFIQQSL
. ......|.. | .|                                              ..|.... .  ...    . |     . | ...... |
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreal

TnSPSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEK
  .... .|.||. | .|. |..... .     | ....| . ......  | .  .  .  .| |...
e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 607-728 7.8e-10 34.0 In-house 100-279 (297) alignment 
Range on Protein: 607-728
Range on HMM: 100-279/297.0
KENINSILNATIEVSL---------PKS---------------------LEHLKFFRVSVSD----------------SIDQPINRYFNDAIEFIQQSLT
..|...|.. | .|.|         |                       |.. . . . |.|                  |  .  .... ..||.. ..
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

NS----PSSSILIHCKEGRSRSTTLAVAFGM--------KALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSLYGY
      ... .|.||. | .|| |...|. |        |  ...... . ....  | .  . ..  .| |..  |. .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_STYXL1_pd Subfamily STYXL1 625-727 1.2e-14 47.8 In-house 54-155 (157) alignment 
Range on Protein: 625-727
Range on HMM: 54-155/157.0
SLEH-LKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTnsPSSSILIHCKEGRSRSTTLAVAFGMKALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEK
....  | ....|.|. .  .   ...|..||..  .   .. .|.  ..| |||.....|. |   |..||..|.|.|.  . .. | .|  || |.||
gvadvakllhiavedeneadllerlkeavqfiekhkk..egevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek

SLYG
.|.|
qllg
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 627-725 7.8e-09 28.8 In-house 45-141 (145) alignment 
Range on Protein: 627-725
Range on HMM: 45-141/145.0
EHLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
|... . .. .|     . ..|..  .||..   .   . ...||  | ||| |..||| ||  ...| ..   |.    .   |  |  .|.. || |
esieillitaedlesydlsqhfdevtdfidkgkee..gagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
PTPlike_phytase Inositol hexakisphosphate 627-687 3.7e-06 21.6 Pfam-A 91-147 (149) alignment 
Range on Protein: 627-687
Range on HMM: 91-147/149.0
EHLKFFRVSVSDSiDQPINRYFNDAIEFIQQSlTNspSSSILIHCKEGRSRSTTLAVAFGM
 ..|..|. ..|   .| .... . ...|...  .  .......|..|| |.||  |   .
fgvkYvRipitde.qapeeedvDafvrliksl.pr..dtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 627-687 3.7e-06 21.6 In-house 91-147 (149) alignment 
Range on Protein: 627-687
Range on HMM: 91-147/149.0
EHLKFFRVSVSDSiDQPINRYFNDAIEFIQQSlTNspSSSILIHCKEGRSRSTTLAVAFGM
 ..|..|. ..|   .| .... . ...|...  .  .......|..|| |.||  |   .
fgvkYvRipitde.qapeeedvDafvrliksl.pr..dtalvfnCqaGrgRTTtamviadL
subfamily_PTPMT1_pd Subfamily PTPMT1 628-725 3.2e-16 54.2 In-house 73-168 (171) alignment 
Range on Protein: 628-725
Range on HMM: 73-168/171.0
HLKFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNspSSSILIHCKEGRSRSTTLAVAFGMKALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
 ........ |  ..|     ....|||..  ..   ... .||| ||.||.||. .. ||  |||...  ...|.  . |....  . .| |||..|
gveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0038934 (Phosphotyrosine protein) phosphatases II 630-725 3.2e-12 42.0 In-house 81-176 (194) alignment 
Range on Protein: 630-725
Range on HMM: 81-176/194.0
KFFRVSVSDSIDQPINRYFNDAIEFIQQSLTNSPSSSILIHCKEGRSRSTTLAVAFGMKALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
.. .  . | .  | .   .. ...... | ..|.  ...||| |..|. ||..|. .. |..|.........   | . .| ..  .|... | |
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
0050432 (Phosphotyrosine protein) phosphatases II 641-702 6.6e-06 21.1 In-house 209-275 (308) alignment 
Range on Protein: 641-702
Range on HMM: 209-275/308.0
DQPINRYFNDAIEFIQQSLTNSPSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVK
|. .  .... ..|...  .  |.. |..||. | .|. |....  .     |  .... . . ...
dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklR
0051299 (Phosphotyrosine protein) phosphatases II 641-706 9.5e-06 20.7 In-house 194-266 (288) alignment 
Range on Protein: 641-706
Range on HMM: 194-266/288.0
DQPINRYFNDAIEFIQQSLTN--SPSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAP
|. .  .... ..|...  .   |... ...||. | .|. |..... .     |  .... . ......  |
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp
0047943 (Phosphotyrosine protein) phosphatases II 644-712 1.1e-06 23.8 In-house 184-258 (273) alignment 
Range on Protein: 644-712
Range on HMM: 184-258/273.0
INRYFNDAIEFIQQSLTNS-PSSSILIHCKEGRSRSTTLAVAFGM-----KALKLSLKDSYEYVKNSAPRININT
   .. . ||.... | ..  .. ...||. | .|. |..... .     |  ...... . ....  | . .. 
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
subfamily_MSG5_pd Subfamily MSG5 662-725 1.1e-16 54.3 In-house 97-160 (165) alignment 
Range on Protein: 662-725
Range on HMM: 97-160/165.0
SPSSSILIHCKEGRSRSTTLAVAFGMKALKLSLKDSYEYVKNSAPRININTGFQFQLMEYEKSL
|    ||.||. | |||..| ||. ||  .|||.|.|. .|. |  |. . |. |||||.|  |
skrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval