Gene DDB_G0271860 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP008_AA protein Get Run
DdisP008_AA_344-475 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049772 (Phosphotyrosine protein) phosphatases II 206-478 6.7e-25 83.9 In-house 45-273 (314) alignment
Range on Protein: 206-478
Range on HMM: 45-273/314.0
PNLNMLNTYDTPilMDPiNKKLNnNTFNNNNNNNIHNNFNNNFNNNIIRLEKidINNNNNNNCNNSQIDLNNNNNIINSNNNNNKNNI------------
.| ......| .    . |     ....... . |. .. ..|.. |.   .   ... ..  . ... .|  . .... .|     .            
lnrdknryldil..pad.nrvil.pglpvsgsdyinasyvdgflkfIatqgp..leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------HNNIDNNNnnslnnninsdkieeplessrwlgcdldklktydpicskvtdylymgSETVASNLEILKsngithiinaSHQCDNFFQDNPMF
          ...| |.                                               .| .|..|| ||          . ..|. .  .. .
LdaAlgKtpllildgng...............................................neptaadlellk..........eelydpelferlgi

EYRKLHLRDsPLEDISLVFEQVIEFIERAiACNGKIFIHCQMGVSRSSC-LCMLWIMKTTRCSLEEASDLVKQVRPiSRPNAGFQLSLLNWAIKE
.|  ... | . ....  |....||||.|   .|....||..|..|. . ... ..||  ..||||| . |.. ||  .|| ||  .|...  ..
kylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil

0040438 (Phosphotyrosine protein) phosphatases II 242-475 2.2e-24 81.7 In-house 9-272 (317) alignment
Range on Protein: 242-475
Range on HMM: 9-272/317.0
NNFNNNFNNNIIRLEKIDINNNNNNNCNNSQIDLNNNNNIINSNNNNNKNNIHNNIDNNNNNslNNNINSDKIEEPLESSRWLGCDLDKlktydpicskv
 .. .. ...... | .|. ... .... ..   | . | . .   .  . .. . ... ..  .. || . .. | .. ... .   .           
lldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPl...........

tdylymgSETVASNLEILKSNGITHIINASHQCDN--------------------------FFQdNPMFEYRKLHLRDS----------------PLEDI
       ..||.. .. .. .|.|.|..  . ...                          ... .. ...|.|.. |.                |  ..
.......pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgv

SLVFEQVIEFIERAIAC----NGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
   ......|.|.. ..    .|.. .|| .||.|. .......|     |. ....||| . ... || . .. ..   |  ..
ppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal

subfamily_LRR-DSP_pd Subfamily LRR-DSP 248-474 1.2e-12 41.5 In-house 32-254 (263) alignment
Range on Protein: 248-474
Range on HMM: 32-254/263.0
FNNNIIRLEKIDINNNNNNNCNNsqidlnNNNNIINSNNNNNKNNIHNNIDNNNNN--------SLNNNINSDKIEEPLESSrwlgcDLDKLKTYD-PIC
...||   ..|. |||..||.||      ||||  . ||| ||||| . |.. . .         ||   | . |  |.|       ....| |.   . 
ydenintcnninsnnndsnnsnn......nnnnnndnnnncnknnileminsteleggglgclkelnirdnrelislpveyk.....qveslitlvssvP

SKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKL-HLRDSPLEDISLVFEQVIEFIERAIAcNGKIFIHCQMGVSRSSCLCML
... | |..|.   | |  |||..|.|||. |  ... .| .  .| |  . ...| .  |||  ||..  |||     .| ...||. |||||| | . 
deiidklflGgldsannksilkdlgvthillavadfePlfPk..lfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsrsstlvis

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||  |  ..|| |||.. ||  .|| ||.  |. .
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky

0040439 (Phosphotyrosine protein) phosphatases II 315-475 4.8e-27 90.6 In-house 20-242 (249) alignment
Range on Protein: 315-475
Range on HMM: 20-242/249.0
EEPLESSRWLGCDLDKLKTYDPICSKVTDYLYMG----------SETVASNLEILKSNGITHIINASHQCDNFF--------------------------
  |...||.   .|..|   | |.  . |. |..          .|||..... |. .|||.|..... . . .                          
ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsve

---------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA------CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASD
               .|.. .... ..  | |  ...  ||....|||..        ..|....|| .||.|. .......|     |. . .|||| .
vkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavk

LVKQVRPISRPNAGFQLSLLNWA
|... || . .| ..   |....
llrsqRpgavqnpeqyrflyeal

0045098 (Phosphotyrosine protein) phosphatases II 317-477 8.3e-28 93.0 In-house 3-270 (278) alignment
Range on Protein: 317-477
Range on HMM: 3-270/278.0
PLESSRWLGCDLDKLKTYDPicSKVTDYLYMGSET-----------------------------------------VASNLEILKSNGITHIINASHQ--
.| |...|     .| ...|  |..|..|| |.                                           ||.... |...|||.|... .   
alasldlllefefllllgip..seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelve

------------------------------------------------CDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA----------
                                                 |.      .. |      ..| ..|.  | ...|||..|..          
lgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

----CNGKIFIHCQMGVSRSSCLCMLWIMKTT---RCSLEEASDLVKQVRPI-SRPNAGFQLSLLNWAIK
     .|....||..||.|. .|.....|..    ...|.|| . ... ||. . .| ...  |  ....
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle

0042113 (Phosphotyrosine protein) phosphatases II 317-474 2.2e-22 75.1 In-house 20-238 (245) alignment
Range on Protein: 317-474
Range on HMM: 20-238/245.0
PLESSRWLGCDLDKLKTYDPI------CSKVTDYLYMGSETVASNLE----ILKSNGITHIINASHQCD-------------------------------
|....|    . .     |.|      ....|. .....   ....|     |...|||.|.. .   .                               
pydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehl

-------------NFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA--CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVK
               ..    . |. |.  | .  |..  .....||...|.|   ||....|| .||.|. .......|     |. . ||||| . ..
ddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelr

QVRPISRPNAGFQLSLLNW
. || .... ..   |  .
sqRpgavqtpsqyrflyea

subfamily_DSP1_pd Subfamily DSP1 320-481 5.8e-84 274.1 In-house 1-159 (163) alignment
Range on Protein: 320-481
Range on HMM: 1-159/163.0
SSRWLGCDLDKLKTYDPICsKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGK
|||||||||||||.|||.. |..|.||.||||||||||||||.|||.|.|.|...||.|.|  .|||.||.|.||| .|||||||.|||||......|||
ssrwlgcdldklklydPve.kildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGk

IFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWAIKEGIQ
..||||.|.||||.||....|||.|.|||||.|.|||.|.|..|||||.|.|||...|.. .
vlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle

0041856 (Phosphotyrosine protein) phosphatases II 322-477 5.9e-32 106.1 In-house 17-171 (182) alignment
Range on Protein: 322-477
Range on HMM: 17-171/182.0
RwlgcdldklktydpICSKVTDYLYMGSETV--------------ASNLEILKSNGITHIINAShqCDNFFQDNPMF---EYRKLHLRDSPLEDislvFE
|               .......||.||                 |..|. ||..|||.|.|..  ... . .. .    .|..|   | .  |    ..
r..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ld

QVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRP--ISRPNAGFQLSLLNWAIK
....|||.... .|....|| .||.|. .|.....||. ..||||| .||.. ||  . .|| .| | |. . ..
elldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_STYXL1_pd Subfamily STYXL1 327-475 9.6e-15 48.1 In-house 3-150 (157) alignment
Range on Protein: 327-475
Range on HMM: 3-150/157.0
DLDKLKTYdPIcSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPM-FEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQ
.||.|||| |.   . . ||.| .  | | .| |   .   .| |...|....  .   .  .... |..  |.   ......|||.    .  ...  .
eldelkty.Pv.evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsn

MGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
 |.||| .. . ..|   . .|..| . .|. ..  .|| .|   | .| 
kGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWe

subfamily_MKPLT_pd Subfamily MKPLT 329-474 2.8e-27 89.3 In-house 15-156 (164) alignment
Range on Protein: 329-474
Range on HMM: 15-156/164.0
DKLKTYDPICskVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGV
 ..|.|  .   . | ||.|    | | ..||   ||||.| | .. . |     .|| .... | . | .|  .|.. .|.  ||   |....||..|.
krikiypsvv..ledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGk

SRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
||||.  . ...|  .  |.|| . .|. | | .|| ||   | ..
srsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf

subfamily_MKPLV_pd Subfamily MKPLV 329-474 2.8e-27 89.3 In-house 15-156 (164) alignment
Range on Protein: 329-474
Range on HMM: 15-156/164.0
DKLKTYDPICskVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGV
 ..|.|  .   . | ||.|    | | ..||   ||||.| | .. . |     .|| .... | . | .|  .|.. .|.  ||   |....||..|.
krikiypsvv..ledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGk

SRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
||||.  . ...|  .  |.|| . .|. | | .|| ||   | ..
srsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf

0036941 (Phosphotyrosine protein) phosphatases II 332-474 9.2e-20 66.6 In-house 13-272 (297) alignment
Range on Protein: 332-474
Range on HMM: 13-272/297.0
KTYDPICSKVTDYLYMGSETVASNLEILK----------------------------------------------------------SNGITHIINASHQ
  .   .......|..|| .||...| |.                                                           ...|.|.. .  
alllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltel

CD-------NFF--------------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA------CNGKIFI
 .        ..                                      .... .. . .|  . |  ..   ......|||..         .|.. .
velgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCQMGVSRSSCLCMLWIM--------KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
|| .||.|| .......|        |. .... ||   ... || . .. .. . |  .
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea

0046846 (Phosphotyrosine protein) phosphatases II 333-474 7.2e-25 83.2 In-house 7-168 (176) alignment
Range on Protein: 333-474
Range on HMM: 7-168/176.0
TYDPICSKVTDYLYMGSET----------VASNLEILKSNGITHIINASHQ-------CDNFFQD--NPMFEYRKLHLRDSPLEDIsLVFEQVIEFIERA
..|. .. ....|..||            .|..|| ||..|||...|           |.|....  .. ..|  |. .|    |.   .....|||..|
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirea

IACNGKIFIHCQMGVSRSSCLCMLWIMKT-TRCSLEEASDLVKQVRP-ISRPNAGFQLSLLNW
.  .|.. .||..|..|. .|........    |.||| .||...||  . .. ..   |  .
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef

0044763 (Phosphotyrosine protein) phosphatases II 334-475 8.9e-38 125.1 In-house 19-167 (178) alignment
Range on Protein: 334-475
Range on HMM: 19-167/178.0
YDPICSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPM-------FEYRKLHLRDSPLEDISLVFEQVIEFIERAI-ACNGKIFIHCQ
. . .|.....||.||   |..|| || .|||||.| .. . ..|....        ..|..... |..  |..  |....||||.|.  ..|....||.
dyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

MGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPiSRPNAGFQLSLLNWA
.||.|| .|.....||. ..||||| .||...||   || |..  |. ..
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefe

PTEN_1 334-472 1.6e-25 85.1 In-house 37-185 (196) alignment
Range on Protein: 334-472
Range on HMM: 37-185/196.0
YDPICSKVTDYLYMGSETVA-SNLEILKSNGITHIINASHQCDN-------FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA--CNGKIFIH
 .|..... . ||.||.. . ..|. ||..|||...| |. ...        .  .  .||.... .| .  ..| .|. . .||| ...  ..... .|
srpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVH

CQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLL
|. |..|| .... . |.. . . .|| .||.. ||  .|| ..|  ||
CkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll

subfamily_DSP6_pd Subfamily DSP6 336-474 3.9e-31 101.7 In-house 12-150 (158) alignment
Range on Protein: 336-474
Range on HMM: 12-150/158.0
PICSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLC
 .  .....||.||.. |||||.||  .| ...|  .. .|.|.... ..| .. ..|   ....  | . ||||. |   . |...||  |.|||  ..
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

MLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
. ..||.. .||..| ||||. ..   ||  |   ||..
laylmkklalslndaydlvkkrksnisPnfnfmgqlldf

0043147 (Phosphotyrosine protein) phosphatases II 337-473 4.9e-28 93.4 In-house 18-155 (172) alignment
Range on Protein: 337-473
Range on HMM: 18-155/172.0
ICSKVTDYLYMGSETVASNLEILKSNGITHIINASHQ-CDNFFQDNPMFEYRKLHLRDSPLEdISLVFEQVIEFIER--AIACNGKIFIHCQMGVSRSSC
|  .. ........|.|.... ||..|||||.|.    .|  .     ..|  |   | .   .. ......|||..  |.  .|.. .|| .||.|. .
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

LCMLWIMKtTRCSLEEASDLVKQVRPISRPNAGFQLSLLN
|.....|.  ..||||| .||.. ||.. .| ...  |. 
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyy

0037934 (Phosphotyrosine protein) phosphatases II 337-474 9.9e-23 76.4 In-house 20-237 (243) alignment
Range on Protein: 337-474
Range on HMM: 20-237/243.0
IC------------------SKVTDYLYMGSE--------TVASNLEILKSNGITHIINASHQC------------------------------------
..                  ..||..|. ..         ..||... |...|||.|..  . .                                    
lpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvr

---------DNFFqdNPMFEYRKLHLRD----SPLEDISLVFEQVIEFIER-----AIACNGKIFIHCQMGVSRSSCLCMLWIMKTT-RCSLEEASDLVK
         |...     . |  |   |    .  ||.   ...|.||||.     |.  .|.. .|| .||.|. .|.....|..  ...|||| .|..
tlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllr

QVRPI-SRPNAGFQLSLLNW
. ||  . .. ..   |  .
eqRpgkavqtpsqyrflyea

PTPc_motif_SM00404 338-475 1.7e-37 123.4 In-house 2-138 (140) alignment
Range on Protein: 338-475
Range on HMM: 2-138/140.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFfQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
.|.....||.||.. |.|...||..||||.||.. ....  . |. |.. .. |.|.  ...|  ...|..|||.|.. .||...|||.||||| .|.. 
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..|..  .||.|| ..||. ||| .||..|  .|... 
YlmryrqlslaeayefvkerRpiispnlnfvrqLieye

subfamily_DSP19_pd Subfamily DSP19 338-474 9.3e-37 120.7 In-house 12-146 (152) alignment
Range on Protein: 338-474
Range on HMM: 12-146/152.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNpmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 ..|...||.||  ||.. ||||...||||.| . . .|.| ..  |.| .... | | .|.. .......||| |   .| ...||. |||||. . . 
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd..ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||... ||||| .||...||  .||.||.  | ..
ylmkkeelsleealelvrearpcikPneGFikqLkey

subfamily_Slingshot_pd Subfamily Slingshot 338-472 3.6e-35 114.8 In-house 19-151 (169) alignment
Range on Protein: 338-472
Range on HMM: 19-151/169.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNpmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 ||. |..|.|||  ||||| ||.||...|.| ....||||...  ||| .... |.. .|.   ...  .|||.| . . |...||.||||||..  . 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpek..feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLL
. ||. ..||||| . ||. | . .||.||   | 
yamkeyglsleealeyvkerrsvikPnkgflkqle

subfamily_DSP10_pd Subfamily DSP10 338-474 1.3e-34 113.4 In-house 14-149 (159) alignment
Range on Protein: 338-474
Range on HMM: 14-149/159.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 |.|  .|..|||. |..|..|.  .||...|   .. |.|..   ..|... ..|.  ....  ||. .|||| |  .. ....||| |.|||. . . 
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..|| .. ||..| ..||. |||  || .|   ||..
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlef

subfamily_DSP14_pd Subfamily DSP14 338-474 2e-34 112.8 In-house 7-140 (157) alignment
Range on Protein: 338-474
Range on HMM: 7-140/157.0
CSKVTDYLYMGsETVASNLEILKSNGITHIINASHQCDNffQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
.|..|..|...  ..|.. | ||...||.|||.. .  |  .. . .|. |. ..|.| ....  |..|.. || . . .||. .|| .|||||  ||. 
lsqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||. . ||.||  |||..||| ||| ||   | ..
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidy

0048179 (Phosphotyrosine protein) phosphatases II 338-474 4.9e-33 109.2 In-house 4-140 (144) alignment
Range on Protein: 338-474
Range on HMM: 4-140/144.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 |.....||.||  .|..|| ||..|||..|| ...... |  .. ..| .| . | .  |..  .....||||.|.. .|....||..||.|. .|...
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||. ..||||| .||.. ||.. || |.   ||..
ylmkklglsleealalvrsrrpgavpnpgqlrfLley

0048076 (Phosphotyrosine protein) phosphatases II 338-475 1.5e-32 107.6 In-house 4-139 (145) alignment
Range on Protein: 338-475
Range on HMM: 4-139/145.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFqdNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 |.....|| || ..|..|| ||..|||...| .. .....  .  ..|  | . | .  |..  .....||||.|.. .|....||..||.|. .|...
pseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..|.. ..||||| .||.. ||.. || |..  |. . 
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_DSP3_pd Subfamily DSP3 338-471 2.8e-29 95.9 In-house 11-150 (162) alignment
Range on Protein: 338-471
Range on HMM: 11-150/162.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQ------C-DNFFQDNPmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC-NGKIFIHCQMGVS
.  |.. ||.| |.||.. . ||  ||||..||..         ..|..|   ..|  |...|.|  |.|  ||.. .||..|..  .||...||..|||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdle.ikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSSCLCMLWIMKTTRCSLEEASDLVKQVRPIsRPNAGFQLSL
||. | . ..| . . .| ||   |.. | | .|| ||   |
RsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqL

subfamily_DSP8_pd Subfamily DSP8 338-475 1.1e-27 90.5 In-house 15-151 (159) alignment
Range on Protein: 338-475
Range on HMM: 15-151/159.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFfQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
  .....||.||.... . |.|. .||....|||..| .  .  .  .. .. ..|.  |... .|.. .|||..| . ||....|.  | |||. . . 
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
.|||| . ||.||   ||. ||   ||  |.  ||.. 
yimktlemsldeayrfvkekrptispnlnflgqLleye

subfamily_DSP12_pd Subfamily DSP12 339-474 4.3e-31 102.4 In-house 3-139 (155) alignment
Range on Protein: 339-474
Range on HMM: 3-139/155.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASHQ-CDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
|.... ||.|. . . . | ||. .|||..   ..  ... ...   ........|.| |||   ......||| |.. .|....|||.|||||. ... 
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||....|||.| .|||...|  .||.||.  |  .
YlmkkeklslekAlklvkekkpeiepNegFleQLklf

subfamily_DSP15_pd Subfamily DSP15 339-475 9.1e-30 97.7 In-house 3-136 (151) alignment
Range on Protein: 339-475
Range on HMM: 3-136/151.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLW
|||   ||.|  ..... | || . ||||.. . .  ....|   .||. ... |.|  ..| .|.. .||| ..   ......|| .|||||  |....
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

IMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
.|  |  . ..| . .|. | .. ||.||.  | .. 
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 339-474 6.7e-27 87.7 In-house 4-148 (154) alignment
Range on Protein: 339-474
Range on HMM: 4-148/154.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDN-------PMFEYRKLHLRDSPLEDISLVFEQVIEFIERAI--ACNGKIFIHCQMGVS
||.. .||..|   | |   |. . |..|.| .   .| | |.        ..|| .|.| | .  ||   .... |||. ||    |.|...|.. |||
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
||..| . ..|.  . || .|  |.|. |.| .|| ||   |  .
rsaallisylmdklkislslalellkdsryiikPnqGflkqleif

0051082 (Phosphotyrosine protein) phosphatases II 339-470 2.5e-24 81.0 In-house 9-145 (151) alignment
Range on Protein: 339-470
Range on HMM: 9-145/151.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASH-----QCDNFFQDNPmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC-NGKIFIHCQMGVSRSS
| ||..|| ..   | .|| ||..||..|.|         | ......  .|.. ... | |  ...| |..|.||.| .... ||....|| .|..|. 
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

CLCMLWIMKtTRCSLEEASDLVKQVRP-ISRPNAGFQLS
.|..|..|.  ..||||| . ... || . .|| .|.. 
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq

0049260 (Phosphotyrosine protein) phosphatases II 340-473 6.2e-26 86.3 In-house 10-144 (152) alignment
Range on Protein: 340-473
Range on HMM: 10-144/152.0
KVTDYLYMGSETVASNLEILKSNGITHIINASHQCDN-FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIER-AIACNGKIFIHCQMGVSRSSCLCML
... ....|..|.|.... ||..|||.|..    ... ... .  ..|  |   |..  |.| .......|||. |.  .|....||  ||.|. .|...
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

WIMKtTRCSLEEASDLVKQVRPISRPNAGFQLSLLN
..|.  ..||||| .||.. ||.. || |.   |..
ylml.lgvsleeavalvrekRpgavpnpgqlrflye

0036282 (Phosphotyrosine protein) phosphatases II 340-472 6.5e-23 76.7 In-house 14-163 (174) alignment
Range on Protein: 340-472
Range on HMM: 14-163/174.0
KVTDYLYMGSETVAsNLEILKSNGITHIINASHQCDN-------------FFQDNPMFEYRKLHLRDSPLEDISLvFEQVIEFIERAIAC--NGKIFIHC
 .|..|. |.   | ..| ||..|||....  . . .              .  .  ..| .|.  |    |.|  ......|.|.|..   .|.. .||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

QMGVSRSSCLCMLWIMKTTRC-SLEEASDLVKQVR---PISRPNAGFQLSLL
 .||.|. .|.....|..  . ||..| |||...|   | . .. ..   | 
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 343-474 1.2e-35 116.2 In-house 13-143 (148) alignment
Range on Protein: 343-474
Range on HMM: 13-143/148.0
DYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKT
 .|..||   |..|| ||  |.|.|.||....|| ...    || .. |.| | ||.| .||..|.|...| .  ... .|.|||||||| | .||....
afLFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidf

TRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
 | ||.|| .|||. |.  .|| ||   | ..
krvslkealalvkskrryvdpnlgfLkqLael

0046845 (Phosphotyrosine protein) phosphatases II 344-461 6.1e-10 34.4 In-house 129-256 (284) alignment
Range on Protein: 344-461
Range on HMM: 129-256/284.0
YLYMGSETVASNLEILKSNGITHIINASHQcdnffQ-DNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC------NGKIFIHCQMGVSRSSCLCM
.|..|  ||    |  |.. ... .  ..      . ... .. . .|  . |  ..   .|...||.. .  .      .|.| .||  ||.|. ....
vltygdftvtllseevkddytvrtleltnl.....gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfia

LWIMKTT--------RCSLEEASDLVKQVRPIS
|.....         .....||   ... || .
ldllleqlekeglllgvdvleavkrlreqRpgm

DSPc Dual specificity phosphatase, catalytic domain 345-475 4.4e-35 115.4 Pfam-A 1-131 (133) alignment
Range on Protein: 345-475
Range on HMM: 1-131/133.0
LYMGSETVASnLEILKSNGITHIINASHQCDN-FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTT
||.||.. || |..|. .|||..||......| ... .. .|| .. ..|.  ..||  .|...||||.|.. ..|...|||.|.||| .|.. ..||| 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..||.|| ..||. |.. .|||||. .||.. 
nlslneAyefvkerrskispnagflrqLleye

DSPc Dual specificity phosphatase, catalytic domain 345-475 4.4e-35 115.4 In-house 1-131 (133) alignment
Range on Protein: 345-475
Range on HMM: 1-131/133.0
LYMGSETVASnLEILKSNGITHIINASHQCDN-FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTT
||.||.. || |..|. .|||..||......| ... .. .|| .. ..|.  ..||  .|...||||.|.. ..|...|||.|.||| .|.. ..||| 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..||.|| ..||. |.. .|||||. .||.. 
nlslneAyefvkerrskispnagflrqLleye

subfamily_STYX_pd Subfamily STYX 345-474 3.2e-19 62.6 In-house 19-153 (166) alignment
Range on Protein: 345-474
Range on HMM: 19-153/166.0
LYMG--SETVASNLEILKSNGITHIINASHQCD-NFFQDN--PMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWI
|..|  | .. | ||.||..|||||.    . . |. . |    | |  | . |...|.|   . .| |||. ..   ||...| . |.|||..| . .|
lflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayi

MKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
|.|      ||   |.. |    ||.||   | ..
metyglkyreafayvqerrfcinpnegfvsqlkey

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 345-474 5.2e-15 48.8 In-house 6-137 (145) alignment
Range on Protein: 345-474
Range on HMM: 6-137/145.0
LYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLE--DISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKT
||.||   |... .|.  ||. |.| .       |.    ..  | .  . ||  |.|  |..| .||..       .|.||  |||||  . . ..|| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

TRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
   .| ||.  |.  |  . ||  |  .||| 
cnmtlseaarqvrsnrllaypnvtflknllnl

0051429 (Phosphotyrosine protein) phosphatases II 348-475 1.1e-15 53.6 In-house 27-221 (272) alignment
Range on Protein: 348-475
Range on HMM: 27-221/272.0
GSET---VASNLEILKSNGITHIINASHQC----DNFFQDNPMFEYRKLHLRDSPLEDISLVF-------------------------------------
..      | ... ||..||..|..  . .    .....  | ..|  |.. |.  ..|.. .                                     
sggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlh

-----------EQVIEFIERAIAcNGKIFIHCQMGVSRSSCLCMLWIMKtTRCS--------------LEEASDLVKQVRPISRPNAGFQLSLLNWA
           |...|..|   . .|.. .||  |..|. ....|...   . |              |||| . ....|| .... .. | |....
ytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

0039614 (Phosphotyrosine protein) phosphatases II 349-475 1.9e-16 55.8 In-house 111-285 (297) alignment
Range on Protein: 349-475
Range on HMM: 111-285/297.0
SETVASNLEILKSNGITHIINASHQCDN------------------------FFQdNPMFEYRKLHL-----------------RDSPLEDISLVFEQVI
.|||.. .. .. .|.|.|..    ...                        ... .... .|.|..                  |    ... .. ...
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

EFIERAIA---CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
|....|.|    .|.. .|| .||.|. .......|     |. . ...|| . ... || .... ..   | ...
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal

0045450 (Phosphotyrosine protein) phosphatases II 350-475 7.7e-23 77.1 In-house 118-300 (307) alignment
Range on Protein: 350-475
Range on HMM: 118-300/307.0
ETVASNLEILKSNGITHIINASHQCDNFFQ--------------------------DNPMFEYRKLHLRDS-----------------PLEDISLVFEQV
|||.. .. |. .|.|.|.. .. ... ..                            . . .|.|.. |.                 |  ...  ||..
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

IEFIERAIA------CNGKIFIHCQMGVSRSSCLCMLWIMKTTR--------CSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..|||.. .      ..|.. .|| .||.|. .......|.. .        ..|.|| .|... || . .| ..   | ...
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

0043336 (Phosphotyrosine protein) phosphatases II 350-473 2.7e-14 48.7 In-house 99-271 (278) alignment
Range on Protein: 350-473
Range on HMM: 99-271/278.0
ETVASNLEILKSNGITHIINAS-------HQCDNFF---------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEF
|||.   . .. .|.|.|..          .|. ..                                 .|.. .. . .|  . |  ..   ......|
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IERAIA----CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLN
.....     .||.. .||  ||.|. ....|...     |. . .|||| . ... || . ..  .   | .
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye

0047943 (Phosphotyrosine protein) phosphatases II 352-471 5.3e-11 37.9 In-house 90-264 (273) alignment
Range on Protein: 352-471
Range on HMM: 90-264/273.0
VASNLEILKSNGITHIINASHQCDN-------FF-------------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVI
|.. .  .. .....|.      ..       ..                                     ...  .... .|  . |  ..   .|...
vedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesll

EFIERAIA------CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSL
|||| .         ||.. .||  ||.|. ....|...     |. . ...||  |... || . ..  . . |
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

subfamily_DSP23_pd Subfamily DSP23 354-461 1.3e-06 23.2 In-house 22-128 (148) alignment
Range on Protein: 354-461
Range on HMM: 22-128/148.0
SNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDISLVfEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDL
.... |  .|. ...  ....    .  |   . .| . |     .  | .. .. .| | . |  . .|| .|  |.  .   ...|  . .  ||   
dqyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

VKQVRPIS
|.. || |
vrrlrpgs

subfamily_CDC14_pd Subfamily CDC14 356-460 2e-08 28.5 In-house 205-306 (328) alignment
Range on Protein: 356-460
Range on HMM: 205-306/328.0
LEILKSNGITHIINASHQcdnfFQDNPMFEYRKLHLRDSPLEDISLVFEQVIE-FIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLV
||  ..|..|...   ..      |.  |.   ..  |   .| |   ..... |.| |  ..|.| .||. |. |  .|   ..||. | . .||   .
leyfrknnvttvvrLnkk....lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawl

KQVRPI
. .|| 
ricrPG

subfamily_MSG5_pd Subfamily MSG5 365-476 2.1e-14 47.0 In-house 49-158 (165) alignment
Range on Protein: 365-476
Range on HMM: 49-158/165.0
THIINASHQCDNFFQDNPMFEYRklHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPN
  .|| ... ...    |  .|   |..      | . . .. . |  | . . ||..||| |.|||..| . .|||    ||..| |..| |     |.
dlvinvakeindlellvpavkyy..hiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

AGFQLSLLNWAI
 |. . |..| .
iglifqlmewev

0038934 (Phosphotyrosine protein) phosphatases II 366-471 5.6e-14 47.7 In-house 57-169 (194) alignment
Range on Protein: 366-471
Range on HMM: 57-169/194.0
HIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDI--SLVFEQVIEFIERAI-----ACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVR
.    .  ..... |   || ....  . | .|   .  .|.. .|.. .        .|.. .|| .|..|. .|.  ..... ..|.||| .|....|
lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR

PISRPNAGFQLSL
| . || ..   |
pgaipnqdyleal

0051299 (Phosphotyrosine protein) phosphatases II 367-465 7.9e-12 40.7 In-house 120-272 (288) alignment
Range on Protein: 367-465
Range on HMM: 120-272/288.0
IINASH-------QCDNFF--------------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC----N
|.           .|. ..                                      .|.  .... .|  . |  ..   .|....|..... .    .
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgg

GKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNA
| . .||  ||.|. ....|...     |. .....||   ... || . .. 
gpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0050432 (Phosphotyrosine protein) phosphatases II 367-465 8.3e-12 40.5 In-house 136-285 (308) alignment
Range on Protein: 367-465
Range on HMM: 136-285/308.0
IIN----------------------ASHQCDNFF----------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC--NGKI
|.                        | ....|.                      .|....... .|  . |  ..   .|....|.|..  .  .|.|
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpi

FIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNA
 .||  ||.|. ....|...     |. .....||   ... || . .. 
vVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0048567 (Phosphotyrosine protein) phosphatases II 384-469 4e-08 27.8 In-house 39-131 (157) alignment
Range on Protein: 384-469
Range on HMM: 39-131/157.0
FEYRKLHLRDSPLED--ISLVFEQVIEFIERAIACNGKIFIHCQMGV---SRSSCLCMLWIMKTTRCSLEEASDLVKQVRP--ISRPNAGFQL
. |  ..  . ||.   .   . .. .|..    ....| .|| .|    .|. .|. .....  . . ||| .....|||  .  . |.. |
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyll

subfamily_PTPMT1_pd Subfamily PTPMT1 403-462 5.7e-12 40.4 In-house 93-152 (171) alignment
Range on Protein: 403-462
Range on HMM: 93-152/171.0
FEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISR
 |. .||||. .    ....||. | .||. |   ..||....|.||| . .|. |.| |
lekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir

PTPc_DSPc_SM00012 403-458 8e-06 21.4 In-house 26-83 (105) alignment
Range on Protein: 403-458
Range on HMM: 26-83/105.0
FEQVIEFIE---RaiacNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLE---EASDLVKQVR
...| .. .   .    .. . .||. ||.|. ....| |.    .. .   . ...||..|
lravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr