Gene DDB_G0281963 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP012_AA protein Get Run
DdisP012_AA_1-144 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Slingshot_pd Subfamily Slingshot 1-146 3e-36 118.4 In-house 16-163 (169) alignment 
Range on Protein: 1-146
Range on HMM: 16-163/169.0
MNDVSRIFPGFYIGS-LPAVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDG-GVLVHCFAGISRSATICI
... |.||   |.||   | | . |.. .....  | .| .  . . ..||.| .||... |..||...|..|||. .|.|  |||||  |.||||.. |
ldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvi

AYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNREN
|| |.. ..|.|.|.  | . | .| ||..|.|||..|| ||. ....
ayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqr
0044763 (Phosphotyrosine protein) phosphatases II 2-145 1.2e-40 134.4 In-house 21-175 (178) alignment 
Range on Protein: 2-145
Range on HMM: 21-175/178.0
NDVSRIFPGFYIGSLPAVN-RNTLDKYQITHVCSVLNEFQPKWTKI---------YKYLHIDIYDSPSVDIMKYFDKTFQFIEEG--RKDGGVLVHCFAG
...|.|.||.|.||||... .. | .. |||.... .|. .   |          ..|||| | |..  |....|.....||||   .|.| ||||| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

ISRSATICIAYIMRKLNISFEDAHGLVSDARPiIYPNESFIKQLKKYELILKKNRE
..||.|...||.|.||..|.|.|  ||  .|| |.||.....||...||.|.|...
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
0045098 (Phosphotyrosine protein) phosphatases II 2-145 2.7e-30 101.1 In-house 20-276 (278) alignment 
Range on Protein: 2-145
Range on HMM: 20-276/278.0
NDVSRIFPGFYIGSLP------------------------------------------AVNRNTLDKYQITHVCSVL-----------------------
...|.|.|. |.|.|.                                          | . ..| ...||.....                        
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

-----------------------------NEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGR---------------KDGGVLVHCFAGISR
                             .....   ....||... ...|| .|.|.|.. ..||.| .               ..| ||||| ||..|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SATICIAYIMRKL---NISFEDAHGLVSDARPI-IYPNESFIKQLKKYELILKKNRE
..|...||.|..|   ......|   .   ||. . .|......| ...| | ....
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_DSP3_pd Subfamily DSP3 2-144 1.1e-28 93.9 In-house 9-161 (162) alignment 
Range on Protein: 2-144
Range on HMM: 9-161/162.0
NDVSRIFPGFYIGS-LPAVNRNTLDKYQITHVcsvLNEFQPKWT------KIYK-----YLHIDIYDSPSVDIMKYFDKTFQFIEEG--RKDGGVLVHCF
..|  ..|. |.|    | ... | |  ||||   ||  . ...      . ||     || ... |.|..|. |||.....||.|   .|.| ||||| 
kevdevypklyvgdeavakdkskLkklGithv...lnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcv

AGISRSATICIAYIMRKLNISFEDAHGLVSDARPiIYPNESFIKQLKKYELILKKNR
.|.|||||. .||.| . ...  .|   | . |  |.||| |.|||....  ||...
vGvsRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelkrkk
subfamily_DSP19_pd Subfamily DSP19 3-140 1.1e-42 139.9 In-house 11-150 (152) alignment 
Range on Protein: 3-140
Range on HMM: 11-150/152.0
DVSRIFPGFYIGSLPAV-NRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKD-GGVLVHCFAGISRSATICIAY
.|. . | .|.||  .. ....|.. .|||. .|  . .  ..| ..||.|.|.| |  |...|......||||.|.  | ||||| ||.||||.. |||
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

IMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELIL
.|.| ..|.|.|  || .||| | ||| ||||||.||  |
lmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP14_pd Subfamily DSP14 3-144 3.8e-39 128.2 In-house 6-148 (157) alignment 
Range on Protein: 3-144
Range on HMM: 6-148/157.0
DVSRIFPGFYIGSLPAVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAYI
 .|.| |  ....  |.....|.|..||..  |  | . . .|  ..... . |.|.....|.||.. . ||| .|.|| .|||| ||.||||..|.||.
alsqitpsLflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNR
|.  ..| ..|. || .||||| ||  | ||| .||  ||.. 
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_DSP10_pd Subfamily DSP10 3-144 6.2e-39 127.4 In-house 13-157 (159) alignment 
Range on Protein: 3-144
Range on HMM: 13-157/159.0
DVSRIFPGFYIGSL-PAVNRNTLDKYQITHVCSVLNEFQPKWTK-IYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDG-GVLVHCFAGISRSATICIA
..|...| ...||   | . ..||...||.|  | ..   ....   || .|.. |. . .. .||.. ..|||| || |  ||||| ||||||||. ||
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNR
|.|..||.|..||. .|...|||| || .|. ||...|  |.|..
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
0041856 (Phosphotyrosine protein) phosphatases II 3-145 2.8e-31 103.9 In-house 18-177 (182) alignment 
Range on Protein: 3-145
Range on HMM: 18-177/182.0
DVSRIFPGFYIGSLP---------------AVNRNTLDKYQITHVCSVLneFQPKWTKIY-----KYLHIDIYDSPSVDimkyFDKTFQFIEEGRKDGG-
| ..| ...|.||||               | . ..| ...||.. ..     . | . .     .||.. . | .  |    .|....|||| ...|| 
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARP--IIYPNESFIKQLKKYELILKKNRE
||||| ||..|..|...||.|.||..|.|.|  ||  .||  .|.||  |. ||. .||.| |. .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
0036282 (Phosphotyrosine protein) phosphatases II 3-141 6e-30 99.6 In-house 11-170 (174) alignment 
Range on Protein: 3-141
Range on HMM: 11-170/174.0
DVSRIFPGFYIGSLPAVNRNTLDKYQITHVCSVLNEFQPK---------------WTKIYKYLHIDIYDSPSVDIMKyFDKTFQFIEEGRKD---GGVLV
|.|.| |....|. |. .   | ...||.| ..|.|....                  ...||.. . |    |. . ... ..|.|| ...   | |||
dlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCFAGISRSATICIAYIMRKLNI-SFEDAHGLVSDAR---PIIYPNESFIKQLKKYELILK
|| ||..|..|...||.| .. . |..||  ||  .|   | .....|....| ..| .|.
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
0046846 (Phosphotyrosine protein) phosphatases II 3-143 1.3e-28 95.3 In-house 11-175 (176) alignment 
Range on Protein: 3-143
Range on HMM: 11-175/176.0
DVSRIFPGFYIGSLP-----------AVNRNTLDKYQITHVCSVLNEFQPKWTKI-----------YKYLHIDIYDSPSVDImKYFDKTFQFIEEGRKDG
|...| .....||.|           | .   | ...||.| ....|.. .. |.           ..|||... |    |. ..... ..||.| .|.|
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

-GVLVHCFAGISRSATICIAYIMRK-LNISFEDAHGLVSDARP-IIYPNESFIKQLKKYELILKKN
  |||||.|||.|..|...||....  ..| |.|  || . ||  . ........|...|| |.|.
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllkk
0037934 (Phosphotyrosine protein) phosphatases II 3-140 4.4e-28 93.9 In-house 38-241 (243) alignment 
Range on Protein: 3-140
Range on HMM: 38-241/243.0
DVSRIFPGFYIGSLPAVN---------RNTLDKYQITHVCSVLNEF---------------------------------------------QPKWTKIYK
. ....|.......|  .          . | ...||..... ...                                             ..    ...
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

YLHIDIYD----SPSVDIMKYFDKTFQFIEE------GRKDGGVLVHCFAGISRSATICIAYIMRKL-NISFEDAHGLVSDARPI-IYPNESFIKQLKKY
|... . |    .   |.....|.. .||||        ..| ||||| ||..|..|...||.| .| ....|.|  |. . ||  . ...|....| ..
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

ELIL
.| |
llel
subfamily_STYX_pd Subfamily STYX 3-141 1.8e-27 89.5 In-house 11-158 (166) alignment 
Range on Protein: 3-141
Range on HMM: 11-158/166.0
DVSRIFPGFYIGSLPAVNRNTLD---KYQITHVCSVLN-----EFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRS
..  |.||...|   |  .  |.   |  |||.  . .       .|.. . ..|| .|. |..  .|..|. .. .||..  . || ||||  ||||||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

ATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILK
|.. |||||    . . .|.  | . |  | ||| |..|||.|| |  
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyl
0042113 (Phosphotyrosine protein) phosphatases II 3-140 4e-26 87.4 In-house 46-242 (245) alignment 
Range on Protein: 3-140
Range on HMM: 46-242/245.0
DVSRIFPGFYIGSLPAVNrnTLD-------KYQITHVCSVLNEFQPKWTK----------------------------------------------IYKY
|..|| |.|.... |. .  |..       ...||..... .|.  .. |                                              .. |
dgyritpkfiatqgPlpe..tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihy

LHIDIYDSPSVDIMKYFDKTFQFIEE---GRKDGGVLVHCFAGISRSATICIAYIM-----RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELIL
..... | .  |....... ..|...     ..| ||||| ||..|..|...||.|     . |..|.|.|   . . || . ...|....| ...| |
hylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 3-136 6.2e-23 76.5 In-house 7-149 (151) alignment 
Range on Protein: 3-136
Range on HMM: 7-149/151.0
DVSRIFPGFYIGSLP-AVNRNTLDKYQITHVCSVLNEFQPKWTKIY------KYLHIDIYDSPSVDIMKYFDKTFQFIEEGRK--DGGVLVHCFAGISRS
. |.. .|.|... | | . ..| ...|...... .|. ... . |      ..||| | | |  ..  .||   .|.|. ..  .| ||||| ||..|.
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATICIAYIMRkLNISFEDAHGLVSDARP-IIYPNESFIKQLKKY
.|....|.|  |..|.|.|   .   || ...||. |..||. .
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP12_pd Subfamily DSP12 4-152 4e-53 174.0 In-house 2-154 (155) alignment 
Range on Protein: 4-152
Range on HMM: 2-154/155.0
VSRIFPGFYIGSLPAVNR-NTLDKYQITHVCSVLNE----FQPKWTKIYkYLHIDIYDSPSVDIMKYFDKTFQFIEEGR-KDGGVLVHCFAGISRSATIC
|||| ||.|.|.|.||.. ..|....||||.|| .|    ...|..|.. ...|.|.|.|..||....|....||||.. ..| |||||.||.|||.||.
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiv

IAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKnRENPQIVEK
|||.|.| ..|.|.|. ||....| |.|||.|..||| .| . .|  .. ....|
iAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck.vdtsnkayk
PTPc_motif_SM00404 4-137 1.7e-39 129.9 In-house 2-138 (140) alignment 
Range on Protein: 4-137
Range on HMM: 2-138/140.0
VSRIFPGFYIGSLPAVN-RNTLDKYQITHVCSVLNEFQP-KWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAY
.||| |. |.||... . .. |.|..|||| .| .| .  | .. ...|.|.. |. . .. ||.||. .|||. .|.|| |||||.||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYE
.||. ..| ..|  .|.. |||| ||..|..|| .||
lmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP1_pd Subfamily DSP1 4-143 2.4e-38 125.8 In-house 18-159 (163) alignment 
Range on Protein: 4-143
Range on HMM: 18-159/163.0
VSRIFPGFYIGS-LPAVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKD-GGVLVHCFAGISRSATICIAYI
| .| .  |.||   | |...|.. .||..  | .| .  . ....| .. . |||. ||...|..  .||.| .|  | ||.|| ||||||.|.|.||.
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
|.. ..|.|.|. .| . |.|| || .|..||..||  |...
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP15_pd Subfamily DSP15 4-143 4.1e-36 118.3 In-house 2-142 (151) alignment 
Range on Protein: 4-143
Range on HMM: 2-142/151.0
VSRIFPGFYIGSLP-AVNRNTLDKYQITHVCSVLNEFQPKWTKiYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGR-KDGGVLVHCFAGISRSATICIAYI
.|.. ||.|.| .  . ... |.. .|||. || .. ..   .  .|. | . |.||....|.|... .|| . | |...|||||.||.|||.|...||.
iskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
|  ......||   .  || .  ||  | .|||.||    |.
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
0048076 (Phosphotyrosine protein) phosphatases II 4-140 1.3e-35 117.5 In-house 4-142 (145) alignment 
Range on Protein: 4-140
Range on HMM: 4-142/145.0
VSRIFPGFYIGSLPAV-NRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKD-GGVLVHCFAGISRSATICIAYI
.|.|.||.|.||||.. .. .| ...||.| .. .|..    ....||.... | .  |....... ..|||| .|. | ||||| ||..|..|...||.
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELIL
|..|..|.|.|  ||  .||.. ||......|...||.|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 4-137 2.4e-34 113.5 In-house 4-141 (144) alignment 
Range on Protein: 4-137
Range on HMM: 4-141/144.0
VSRIFPGFYIGSLPA-VNRNTLDKYQITHVCSVLNEFQPKWTKIY--KYLHIDIYDSPSVDIMKYFDKTFQFIEEG-RKDGGVLVHCFAGISRSATICIA
.|.|.||.|.||||. ..  .| |..||.|... .|. | . . .  .|||... | .  |..........||||  ...| ||||| ||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYE
|.|.||..|.|.|  ||  .||...||......|..||
ylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_DSP8_pd Subfamily DSP8 4-143 1.3e-30 100.0 In-house 15-157 (159) alignment 
Range on Protein: 4-143
Range on HMM: 15-157/159.0
VSRIFPGFYIGSLP-AVNRNTLDKYQITHVCSVLN-EFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRK-DGGVLVHCFAGISRSATICIAY
. || .  |.||   ......|.|. |..|  . |   ...  |  |.|.. . |. . ... .|||...||.  .. .| ||||..||||||||. |||
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

IMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
||..|..|...|.  | . || | ||  |..|| .||  ||..
imktlemsldeayrfvkekrptispnlnflgqLleyekelkll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 5-141 2.2e-44 145.5 In-house 121-259 (263) alignment 
Range on Protein: 5-141
Range on HMM: 121-259/263.0
SRIFPGFYIGSLP-AVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHI-DIYDSPSVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAYIM
. | .....|.|  | |.. | . ..||.   . .|.| . |..||| | || | .  || ..|..|  ||||||| ||||||| ||.|||.|. |.|.|
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGvlvhcraGvsrsstlvisylm

RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILK
.| .. |..|  ||   || |.||  |..||||||  | 
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 5-137 1.3e-22 73.9 In-house 8-144 (148) alignment 
Range on Protein: 5-137
Range on HMM: 8-144/148.0
SRIFPGF-YIGSLP-AVNRNTLDKYQITHVCSVLNEFQPKWT-KIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAY
| | ..| ..|| . | . ..| .  .|.. .  .| .  .  .  .|||. . | |  |. ..|..  .|... ...|. ||||.  |.|||. . ...
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallw

IMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYE
...  ..| ..|  || ..|. . ||  |.||| ..|
lidfkrvslkealalvkskrryvdpnlgfLkqLaele
subfamily_DSP6_pd Subfamily DSP6 6-142 2.9e-35 115.1 In-house 16-156 (158) alignment 
Range on Protein: 6-142
Range on HMM: 16-156/158.0
RIFPGFYIGSL-PAVNRNTLDKYQITHVCSVLNEFQPKWTKIY--KYLHIDIYDSPSVDIMKYFDKTFQFIEEGRK-DGGVLVHCFAGISRSATICIAYI
.| | .|.||   | |...|.|..| .|  | .. . |. .    |||.| | |  | ...|.| ....||.|.|. . .|||||.|||||| |...||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKK
|.||..|..||. || . .. | || .|..||...|  |. 
mkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
PTEN_1 6-143 2.3e-27 91.1 In-house 43-194 (196) alignment 
Range on Protein: 6-143
Range on HMM: 43-194/196.0
RIFPGFYIGSLPAVN--RNTLDKYQITHVCSVLNEFQP------KW---TKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRK---DGGVLVHCFAGIS
.|..| |.|||. |   ...|..  ||.|... .|.        .     . ..|||..| | .  .. . ||   .|||  ..    . ||||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
||.|...|| |.| . ....|  || ..|| . || .. ..|..|.  |...
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0051429 (Phosphotyrosine protein) phosphatases II 6-139 3.8e-21 71.4 In-house 18-223 (272) alignment 
Range on Protein: 6-139
Range on HMM: 18-223/272.0
RIFPG-FYIGSLP----AVNRNTLDKYQITHVCSVLNEFQPKWTKI------YKYLHIDIYDSPSVDIM-------------------------------
.. || .| .. |    | .  .| ...|...... .|.  .. |        .|||..|.|.   .|                                
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------KYFDKTFQFIEEgrkDGGVLVHCFAGISRSATICIAYIMRkLNIS--------------FEDAHGLVSDARPIIYPNESF
                    ... . .... .   .| |||||.||..|..|.. ....  |..|               |.|   . ..|| . ..| .
earevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

IKQLKKYELI
...| ...| 
ylflyealle
0039614 (Phosphotyrosine protein) phosphatases II 8-143 3.5e-23 77.9 In-house 100-291 (297) alignment 
Range on Protein: 8-143
Range on HMM: 100-291/297.0
FPGFYIGSLPAVN-----RNTLDKYQITHVCSVLNEFQPKWtKIYK-------------------------------------------YLHIDIYDSPS
 . |.. . |  .      . . ....|.. .. ...  .. | ..                                           ...... |   
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgv

VDIMKYFDKTFQFIEEGR----KDGGVLVHCFAGISRSATICIAYIM-----RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
 ........ .....| .    |.| ||||| ||..|..|...||.|     .. ......|   .  .|| . ...|....| ...| | |.
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 8-139 3.9e-19 64.6 In-house 87-275 (278) alignment 
Range on Protein: 8-139
Range on HMM: 87-275/278.0
FPGFYIGSLPAVNR-----NTLDKYQITHVCSVLNEFQPKWTK-----------------------------------------------IYKYLHIDIY
 ..|.. . |  .      . . ....|.. .. ...  ...|                                               .| ||..  .
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

DSPSvDIMKYFDKTFQFIEEGR-KDGGVLVHCFAGISRSATICIAYIM-----RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELI
. |. ..  ..|   ...|  . ..| ||||| ||..|..|....|..     . .....|.|   .   || . ...|....| ...| 
gvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 11-137 5e-33 107.6 In-house 10-149 (154) alignment 
Range on Protein: 11-137
Range on HMM: 10-149/154.0
FYIGSL-PAVNRNTLDKYQITHVCSV----LNEFQPK-----WTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGR---KDGGVLVHCFAGISRSATIC
.||.|  .|.|.  |....|...  |     | |  .        |..||.....| .  ||.. .||.|.||..     ....||||. .|.||||.. 
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

IAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYE
|.|.| ||.||.  |  |. |.|.|| ||. |.|||...|
isylmdklkislslalellkdsryiikPnqGflkqleife
DSPc Dual specificity phosphatase, catalytic domain 12-137 1.1e-33 110.9 Pfam-A 2-131 (133) alignment 
Range on Protein: 12-137
Range on HMM: 2-131/133.0
YIGSLPAVNRNTLDKYQITHVCSVLNEFQPKWT---KIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAYIMRKLNI
|.|| .. . . |.|..||.| .| .| . ...   . ..||.| . |. . .| |..... .|||. ...|. ||||| ||||||||..|||.|.. |.
ylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl

SFEDAHGLVSDARPIIYPNESFIKQLKKYE
| ..|  .|.. |..| ||..|..|| .||
slneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 12-137 1.1e-33 110.9 In-house 2-131 (133) alignment 
Range on Protein: 12-137
Range on HMM: 2-131/133.0
YIGSLPAVNRNTLDKYQITHVCSVLNEFQPKWT---KIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAYIMRKLNI
|.|| .. . . |.|..||.| .| .| . ...   . ..||.| . |. . .| |..... .|||. ...|. ||||| ||||||||..|||.|.. |.
ylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl

SFEDAHGLVSDARPIIYPNESFIKQLKKYE
| ..|  .|.. |..| ||..|..|| .||
slneAyefvkerrskispnagflrqLleye
0043147 (Phosphotyrosine protein) phosphatases II 14-141 4.5e-31 103.3 In-house 30-161 (172) alignment 
Range on Protein: 14-141
Range on HMM: 30-161/172.0
GSLPAVNRNTLDKYQITHVCSVLNE---FQPKWTKIYKYLHIDIYDSPSVdIMKYFDKTFQFIEE---GRKDGGVLVHCFAGISRSATICIAYIMRkLNI
..  | ... | ...|||. .. ..    .. .  ...||.. ..| .   ..........||.|    ...| ||||| ||..|..|...||.|. |..
rntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lgl

SFEDAHGLVSDARPIIYPNESFIKQLKKYELILK
|.|.|  || ..||.. .|.|....|...| .|.
sleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_DSP23_pd Subfamily DSP23 14-123 3.7e-07 24.9 In-house 18-128 (148) alignment 
Range on Protein: 14-123
Range on HMM: 18-128/148.0
GSLPAVNRNTLDKyQITHVCSVLNEFQPKWTK----IYKYLHIDIYDSPSVDIMKYFdktFQFIEEG-RKDGGVLVHCFAGISRSATICIAYIMRKLNIS
 .||.  |  ||.  . .. |. .| .|.        .. | || |  |... .. |    . .||   |.  | |||  |  |. |.   |.... ...
prlpdqyrylldl.gvrylvslteegrphveatpnltlvrlriddyhppaleqvvef...vrvveeaeekneavsvhcllgrgrtgtmlacylvkerkla

FEDAHGLVSDARPII
  .|   |   ||  
aaeaiaevrrlrpgs
0040439 (Phosphotyrosine protein) phosphatases II 15-141 8.9e-28 93.0 In-house 65-246 (249) alignment 
Range on Protein: 15-141
Range on HMM: 65-246/249.0
SLPAVNRNTLDKYQITHVCSVLNEFQP-------------------------------------------KWTKIYKYLHIDIYDSPSVDIMKYFDKTFQ
.  . ... | ...||..... .....                                           .  . ...||| ..| |  .. ..|. ...
etvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlld

FIEEGRK-------DGGVLVHCFAGISRSATICIAYIM-----RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILK
|||. ||       .| ||||| ||..|..|...||.|     ..|....|.|  |. ..|| . .|......| ...| | 
fieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0049260 (Phosphotyrosine protein) phosphatases II 17-140 5.2e-30 99.5 In-house 22-149 (152) alignment 
Range on Protein: 17-140
Range on HMM: 22-149/152.0
PAVNRNTLDKYQITHVCSVLNEFQP---KWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEE--GRKDGGVLVHCFAGISRSATICIAYIMRkLNISFED
 | . . | ...||.. .. ...     |. . ..|||. . |..  |.  ...  ..|||.   .|.| |||||.||..|..|...||.|. |..|.|.
ladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvslee

AHGLVSDARPIIYPNESFIKQLKKYELIL
|  ||  .||...||......|...| .|
avalvrekRpgavpnpgqlrflyefekll
subfamily_MKPLT_pd Subfamily MKPLT 18-139 2e-25 83.2 In-house 37-160 (164) alignment 
Range on Protein: 18-139
Range on HMM: 37-160/164.0
AVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAYIMRKLNISFEDAHGLV
| |.. |.. .|||.. | .| . ...|  .|| ... | .   ........ .|. .  . || |||||  | |||... .|....     ...|.  .
atnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeyl

SDARPIIYPNESFIKQLKKYEL-I
 . | |. ||  |.||| |.|  |
kerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 18-139 2e-25 83.2 In-house 37-160 (164) alignment 
Range on Protein: 18-139
Range on HMM: 37-160/164.0
AVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGG-VLVHCFAGISRSATICIAYIMRKLNISFEDAHGLV
| |.. |.. .|||.. | .| . ...|  .|| ... | .   ........ .|. .  . || |||||  | |||... .|....     ...|.  .
atnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeyl

SDARPIIYPNESFIKQLKKYEL-I
 . | |. ||  |.||| |.|  |
kerrsivapnrGflkqlakfeeli
0046845 (Phosphotyrosine protein) phosphatases II 20-132 1.6e-15 52.7 In-house 141-265 (284) alignment 
Range on Protein: 20-132
Range on HMM: 141-265/284.0
NRNTLDKYQITHVCSVLN--EFQPKWTKIYKYLHIDIYDSP--SVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAYIMRKL--------NI
.... | | ..... . .  . ...  ... |...  .. |  . |.......  ...|.  ..| ..||| ||..|..|....... ..        ..
seevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgv

SFEDAHGLVSDARPIIYPNESFIKQ
....|   . . ||    ... .. 
dvleavkrlreqRpgmvqtleqyrf
0051299 (Phosphotyrosine protein) phosphatases II 20-129 2.2e-14 49.1 In-house 155-274 (288) alignment 
Range on Protein: 20-129
Range on HMM: 155-274/288.0
NRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRK-----DGGVLVHCFAGISRSATICIAYIM-----RKLNISF
.  .||.| ..... . ...  .  . ... |.  .. |  ..  ...  ..|... ||     .| |.||| ||..|..|.......     ..  ...
seevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdv

EDAHGLVSDARPIIYPNESF
..|   .   || . .... 
leavkrlreqRpgmvqtpeq
Astro_capsid Astrovirus capsid protein precursor 21-250 9.2e-07 13.7 Pfam-A 527-756 (787) alignment 
Range on Protein: 21-250
Range on HMM: 527-756/787.0
RNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISrsATICIAYIMRKLNISFEDAHGLVSDAR
  | .| |.| |  | .  . ..|.  ...     .  ... .|  ..| ..  | ... . |.....  .  |..   ... . ... . |        
sstnnkhqvtsvflvrvtkdlqvtnytslvlraaantsaaenlkvrsdtasvsvelksgewylltsttive..aavkegwvwlnvelknntayladqvla

PIIYPNESFIKQLKKYELILKKNRENPQIVEKESEEedDDEDDDDDDYDSDEDDDDDSEDDDFEEEFDNV---VKKKNNN-----NKKVNVKNTtkvFSN
 .| |...  | | . .  |...... . .|... |  |.|....|.....| | .. ...| ..| | .     .....     |..| . .|   . |
hlitplgeaskilfelrtalpeekaelseleerave..daeepaedlvseeetdtetestedesdeldrfdlkassgsesededennrvtllst...lin

ISISSEQTtTSTTTVPTPTLNPETKIEETTTTTTATAT
 .|| |.. |  |. ..|||..... . .. . .. ..
qgisvera.tkitkrafPtlaekvrrsvykdllvegvr
0038934 (Phosphotyrosine protein) phosphatases II 23-148 2.1e-24 81.7 In-house 37-184 (194) alignment 
Range on Protein: 23-148
Range on HMM: 37-184/194.0
TLDKYQITHVCSVLNEFQPKWTKIY-------------------KYLH---IDIYDSPSVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAY
 | .. .......|.... |.....                   .||.   .| . .|| .|.. | .  ... .  ..| |.||| ||..|..|...||
elyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY

IMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNRENPQ
.. .|..| |.| .|....|| ..|| .....| |.   |.|.   |.
LiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlape
0040438 (Phosphotyrosine protein) phosphatases II 23-146 1.4e-22 75.8 In-house 105-281 (317) alignment 
Range on Protein: 23-146
Range on HMM: 105-281/317.0
TLDKYQITHVCSVLNEFQPK---------------------------WTKIYKYLHIDIYDS----------------PSVDIMKYFDKTFQFIEEGRK-
 . ....|.. .. ......                           . . ...... ..|.                |  .. ...|  ..|.|. |. 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----DGGVLVHCFAGISRSATICIAYIM-----RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNREN
    .| ||||| ||..|..|...||.|     .. ....|.|   .  .|| . ........| ...| . |....
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0047943 (Phosphotyrosine protein) phosphatases II 23-133 1.5e-16 56.2 In-house 146-264 (273) alignment 
Range on Protein: 23-133
Range on HMM: 146-264/273.0
TLDKYQITHVCSVL-NEFQPKWTKIYKYLHIDIYDSP--SVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAYIM-----RKLNISFEDAHG
| | | ..... .  .  ...  ... |...  .. |    ........  ...|. ...| |.||| ||..|..|.......     .. ......|  
tkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavk

LVSDARPIIYPNESFIKQL
|. . || . ........|
llrsqRpgmvqtpeqyrfl
0045450 (Phosphotyrosine protein) phosphatases II 24-142 1.7e-25 85.8 In-house 127-305 (307) alignment 
Range on Protein: 24-142
Range on HMM: 127-305/307.0
LDKYQITHVCSVLNEFQPKWTKI----------------------------YKYLHIDIYDS-----------------PSVDIMKYFDKTFQFIEEGR-
| ....|..... ...  .. |.                            |..... . |.                 |  .. ..|. ...|||| | 
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------KDGGVLVHCFAGISRSATICIAYIMRKLN--------ISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKK
      |.| ||||| ||..|..|...||.| ..         .....|  |. . || . .|......| ...| | .
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_PTPMT1_pd Subfamily PTPMT1 24-140 1.1e-17 59.0 In-house 54-168 (171) alignment 
Range on Protein: 24-140
Range on HMM: 54-168/171.0
LDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVdimKYFDKTFQFIEEGRKDG-GVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPI
 . |......   .|..    .....  .|. ..|..   .   |. .|||. ...|  | ||| || .||||. ..|.| | ..| |.|.  . . |.|
neeyelkalansteewkklgveqlqlatvDfteapdl...eklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki

IYPNESFIKQLKKYELIL
|  ..   |.|..||  |
irlakkqwkalqeyeekl
0049772 (Phosphotyrosine protein) phosphatases II 25-152 1.1e-33 112.8 In-house 167-285 (314) alignment 
Range on Protein: 25-152
Range on HMM: 167-285/314.0
DkyqithvcsvlNEF--QPKWTKI-YKYLHIDIYDsPSVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSAT-ICIAYIMRKLNISFEDAHGLVSDAR
            .|   ......  .|||.|...| .|... ..||. ..|||| .|.| ||||| ||..|..| ...||.|..|..|.|.|   |  .|
k...........eelydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkR

PiIYPNESFIKQLKKYELILKKNRENPQIVEK
| |.||..||.||. || ||.  .|  . ..|
p.inpnpgfieqleqyefilealleylkflkk
0036941 (Phosphotyrosine protein) phosphatases II 26-146 1e-20 69.7 In-house 100-282 (297) alignment 
Range on Protein: 26-146
Range on HMM: 100-282/297.0
KYQITHVCSVLNEFQPKWTKIYKYL-----------------------------------------------HIDIYDSPSVDIMKYFDKTFQFIEEGRK
....|.. .. ....    | ..|                                                |. . . |  ..  ...  ..|||. ||
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

-------DGGVLVHCFAGISRSATICIAYIM--------RKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNREN
       .| ||||| ||..||.|...|..|        .  .... .|   . . || . ..... ..|  ..| | |....
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_STYXL1_pd Subfamily STYXL1 31-138 7.4e-22 71.2 In-house 43-151 (157) alignment 
Range on Protein: 31-138
Range on HMM: 43-151/157.0
HVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDG-GVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESF
.| .  ....  .... | |||.. |..  |... ...  ||||. .|.|  |||    ||||||.. |||.| . .|....|.  . . .. . || .|
nvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnraf

IKQLKKYEL
..||...| 
veqlseWek
0050432 (Phosphotyrosine protein) phosphatases II 35-129 3.1e-13 45.2 In-house 139-287 (308) alignment 
Range on Protein: 35-129
Range on HMM: 139-287/308.0
VLNEFQP-------------------------------------------------KWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGGVLVH
. ....                                                  .  ... . ...  |    . .. . . ...... ...| ..||
LtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVH

CFAGISRSATICIAYIM-----RKLNISFEDAHGLVSDARPIIYPNESF
| ||..|..|.......     .. ......|   .   ||   .... 
CsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 47-143 5.8e-20 64.9 In-house 47-144 (145) alignment 
Range on Protein: 47-143
Range on HMM: 47-144/145.0
YKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDG-GVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
.. | |   |  | |. ..||.  .||. |...| ||.|||.||.||| |. .|..|.  |... .|   |   |   |||  |.|.| . |  ||..
ieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
DSPc_SM00195 47-107 1.2e-06 23.4 In-house 158-224 (263) alignment 
Range on Protein: 47-107
Range on HMM: 158-224/263.0
YKYLHIDIYDSPSVDIM---KYFDKTFQFIEEGRK--DGGVLVHCFAGISRSATICIAYIMR-KLNI
.|  .. . . |  ..    |.. . ...... ..  .| ..||| ||..|..|.. . |.  ||. 
rkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilsklee
PTPc_SM00194 47-107 1.2e-06 23.4 In-house 158-224 (263) alignment 
Range on Protein: 47-107
Range on HMM: 158-224/263.0
YKYLHIDIYDSPSVDIM---KYFDKTFQFIEEGRK--DGGVLVHCFAGISRSATICIAYIMR-KLNI
.|  .. . . |  ..    |.. . ...... ..  .| ..||| ||..|..|.. . |.  ||. 
rkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilsklee
0048567 (Phosphotyrosine protein) phosphatases II 51-128 4.9e-09 30.7 In-house 41-128 (157) alignment 
Range on Protein: 51-128
Range on HMM: 41-128/157.0
HIDIYDS----PSVDIMKYFDKTFQFIEEGR-KDGGVLVHCFAGI---SRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPN--ES
..| .      .   ..... |  .|..  . ... . ||| ||    .|.||.. .|.. .|... |.| .... .|| ..|    |
yedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdas
PTPc_DSPc_SM00012 55-110 2.8e-09 32.5 In-house 13-70 (105) alignment 
Range on Protein: 55-110
Range on HMM: 13-70/105.0
YDSPS--VDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAYIMRKLNISFE
   |.   .|....... .. ..  . . |.|||.||..|..|.. ..|. . . . .
hgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket
subfamily_PTPDC1_pd Subfamily PTPDC1 55-143 1.8e-06 22.5 In-house 93-178 (182) alignment 
Range on Protein: 55-143
Range on HMM: 93-178/182.0
YDSPSVDIMKYFDKTFQFieeGRKDGGVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
|...|.. .    |  .|     ..| | ||| ||  |   .  .|.. . ... |.|  || . ||      . .. .|...| |.. 
ygvasleriLdivkvvaf...alqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflipl
subfamily_RNGTT_pd Subfamily RNGTT 56-139 1.1e-07 25.8 In-house 90-174 (189) alignment 
Range on Protein: 56-139
Range on HMM: 90-174/189.0
DSPSVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQL-KKYELI
..|. . .| | |  .   . . .  . |||  |  |.  . ..|.. | ..| |.|  | . |||    .| ..|.| ..|. .
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv
subfamily_DSP11_pd Subfamily DSP11 56-136 4e-06 20.8 In-house 91-173 (178) alignment 
Range on Protein: 56-136
Range on HMM: 91-173/178.0
DSPSVDIMKYFDKTF-QFIEEGRK-DGGVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKY
. |. ...| | ..  .|.|.  . |  . |||  |. |.  .   |.. . ... |||    ..||      | ..|.||| 
evpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
subfamily_CDC14_pd Subfamily CDC14 57-131 7.8e-07 23.2 In-house 246-317 (328) alignment 
Range on Protein: 57-131
Range on HMM: 246-317/328.0
SPSVDIMKYFDKTFQFIeegrkDGGVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARP--IIYPNESFIK
 ||  |.| | .  . .     .|.. ||| ||. |  |.  .|.|.. ... ..| . .  .||  .| | ..|..
tPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfle
subfamily_MSG5_pd Subfamily MSG5 61-143 4.4e-14 45.9 In-house 80-163 (165) alignment 
Range on Protein: 61-143
Range on HMM: 80-163/165.0
DIMKYFDKTFQFIEEGR-KDGGVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKN
 |.| . .  . |   . |   .||||  |.||||.. .||||.  |.|..||. ..      | |.  .| || ..| .|.|.
kivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
Y_phosphatase Protein-tyrosine phosphatase 63-103 6.7e-06 21.1 Pfam-A 152-194 (235) alignment 
Range on Protein: 63-103
Range on HMM: 152-194/235.0
MKYFDKTFQFIEEGR--KDGGVLVHCFAGISRSATICIAYIMR
 | . .. . .|. .  |.| |.||| ||..|..|.. . |. 
pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 63-103 6.7e-06 21.1 In-house 152-194 (235) alignment 
Range on Protein: 63-103
Range on HMM: 152-194/235.0
MKYFDKTFQFIEEGR--KDGGVLVHCFAGISRSATICIAYIMR
 | . .. . .|. .  |.| |.||| ||..|..|.. . |. 
pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
DUF2457 Protein of unknown function (DUF2457) 134-252 1.5e-08 21.0 Pfam-A 33-149 (458) alignment 
Range on Protein: 134-252
Range on HMM: 33-149/458.0
KKYELILKKNRENP-QIVEKE-SEEEDDDEDDDDDDYDSDEDDDDDSEDDDfEEEFDNVVKKKNNNNKKVNVKNTTKVfSNisiS-SEQTTTSTTTVPTP
||   | |. .|   . .|.|  .|.|...|||||. | |||||.| |||. ... | .........   . .| ..  ..   |  |. . |  .  .|
kkenairklgeeaeeealeeedededdeedddddDeddddedddeddedde.lddddstladassaddGnetdneagf.ae...SdDesddgsdyefWap

TLNPETKIEETTTTTTATATAT
.   .... |.. |...... .
kaltaatlsekletlrrkirrr
CDC45 CDC45-like protein 136-200 1.2e-06 15.0 Pfam-A 117-186 (622) alignment 
Range on Protein: 136-200
Range on HMM: 117-186/622.0
YELILKKNRENPQIVEKESEEEDDDEDDDDDDYDSDED-----DDDDSEDDDFEEEFDNVVKKKNNNNKK
.. . .. .|...  |.||.|..|.|.|....  |...     .|.| |||| ||. |.  .|..|....
ekdayealvemkeeeeeesdedsdseedeeseessksekeksesdedeeddddeedederkrkrsnssss
SDA1 SDA1 137-210 3.6e-06 13.7 Pfam-A 72-129 (324) alignment 
Range on Protein: 137-210
Range on HMM: 72-129/324.0
ELILKKNRENPQIVekESEEEDDDEDDDDDDYDSDEDDDDDSEDDdfEEEFDNVVKKKNNNnkkvnvknttkvF
||. |.. |. .    |.||....|.|.| ..|.|.|..|..|||  |.|. .| . |...             
ElLekdkeeerkkk..eeeegeeseedsdeeWdvdsdeededeDd..egewvdvesdkeee............s
Nop14 Nop14-like family 142-264 7.2e-08 18.6 Pfam-A 334-457 (840) alignment 
Range on Protein: 142-264
Range on HMM: 334-457/840.0
KNRENPQIVEKESEEEDDDEDDDDDDY----DSDEDDDDDSEDDDFEEEFDNVVKKKNNNNKKVNVKNtTKVFSNISISSEQTTTSTTTVPTPTLNpeTK
...|. .  |.|..|..|.|.||||.     |.|||.....|.|. ... ..  ......... . |. .|. .. . ..|. ..  .|.|.|.     .
saeeeeeeeeeegvededeeeddddeeeeeedvdedeeeedeedeesddeeeeeeeeeseeeaeakkk.kktkkkkkskeetkeelpftfpcPksh..ee

IEETTTTTTATATATLVEEVVESTSPK
..|.    ..  ..|.|. ...  .||
llellkdvsledqptvvkrIrklhhpk
Daxx Daxx Family 148-267 2.7e-08 21.8 Pfam-A 443-570 (713) alignment 
Range on Protein: 148-267
Range on HMM: 443-570/713.0
QIVEKESEEEDDDEDDD----DDDYDSDEDDDDDSEDDDFEEEFDNVVKKKNNNNKKV-NVKNTTKVFSNISISSEQTTTSTTTVPT-PTLNPETK--IE
. .|||..||||.....    ... . .|.......|.. ||. ..  .........  . .....| . | .| ||.   ....|  |. .|. .  ..
ekaekeedeeddekeeedkseeeeeeeeeeeeeeeadneeeedleassegegddeeeeedeekndevakgirvseeqqkressvqpespkeepqepeavd

ETTTTTTATATATLVEEVVESTSPKATL
....       ..  ||...|  .  . 
aekegeesdeellaeeeplsshtelesv
YL1 YL1 nuclear protein 154-245 3.5e-07 16.4 Pfam-A 46-147 (240) alignment 
Range on Protein: 154-245
Range on HMM: 46-147/240.0
SEEEDDDEDDDDDDYDSDEDDdDDSEDDDFEEEF-----DNVVKKKNNNNKKVNVKNTTKVFSNISIS-------SEQTTTSTTTVPTPTLNPETkIEET
.|||...| ..|.| |..||| . ..||. |.|      ..  |||. ..|. . . . |. .. . .       .|. . .....  .|| ... . . 
eeeeeeeeeetDsdfddsedd.eeesddeeegekelekeekekkkkrkkkkaykeplkkkkkkkkkaakkkeaaaeekkkkkeekseaetlldkk.rRkS

TTTT
. ..
sRss
C1_4 TFIIH C1-like domain 266-292 4.6e-06 14.1 Pfam-A 18-42 (51) alignment 
Range on Protein: 266-292
Range on HMM: 18-42/51.0
TlgEHRYSCRKCSKDLFLDFDILDHEQ
.  ...|.|.|| ..  .| |.  ||.
d..ssvyrCekCknvFCidCDvFiHes