Gene mpl1 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily LRR-DSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP016_AA protein Get Run
DdisP016_AA_693-832 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
LRR_4 Leucine Rich repeats (2 copies) 159-199 3e-11 32.6 Pfam-A 1-41 (44) alignment 
Range on Protein: 159-199
Range on HMM: 1-41/44.0
TELRSLILDFNKITEIPEQIGLLPNLKHLSLAANQLSQVPE
| |..| |  |.|...|.... |||||.|.|. |..| ...
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 160-215 9.6e-11 30.9 Pfam-A 2-59 (61) alignment 
Range on Protein: 160-215
Range on HMM: 2-59/61.0
ELRSLILDFNKITEIPE-QIGLLPNLKHLSLAANQLSQVP-EFLSQLKSLESLELGIN
.|..|.|..|....||.   . |.|||.|.|  | |. .. | ...|.||..| |  |
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN
LRR_4 Leucine Rich repeats (2 copies) 182-221 7.3e-11 31.4 Pfam-A 1-40 (44) alignment 
Range on Protein: 182-221
Range on HMM: 1-40/44.0
PNLKHLSLAANQLSQVPEFLSQLKSLESLELGINQFTSFP
.||..|.|. |.....|. |..|..|..| |  |......
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 229-284 5.8e-07 18.8 Pfam-A 2-61 (61) alignment 
Range on Protein: 229-284
Range on HMM: 2-61/61.0
SLTLLRLETNNIKSLPDDFIN-LENLKDLSLLDNQLKEIPDSL---PNNIEKLNLGCNDI
.|. | |  |..|..|... . |.||| |.|  | ||.|.. .    .....|||  |..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_8 Leucine rich repeat 273-332 3.6e-07 19.5 Pfam-A 2-61 (61) alignment 
Range on Protein: 273-332
Range on HMM: 2-61/61.0
NIEKLNLGCNDIInSYSKSLIRISHSLTTLNLSENKIEVLD-ESLSCLVNVKTLILDCNMI
|...|.| .|..  . ...     ..|..|.||.|...... |....|.... | |. |..
nLkeLdLsnNrlk.viptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 298-332 1.5e-07 20.8 Pfam-A 2-36 (44) alignment 
Range on Protein: 298-332
Range on HMM: 2-36/44.0
SLTTLNLSENKIEVLDESLSCLVNVKTLILDCNMI
.|..|.||.|.|. |...|. | | ||| |. | |
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpi
LRR_8 Leucine rich repeat 321-379 1.4e-11 33.6 Pfam-A 2-61 (61) alignment 
Range on Protein: 321-379
Range on HMM: 2-61/61.0
NVKTLILDCNMIKVIPGSVLGSWKSLVTLNLPHNFISDLPAEI-VTLDNLRIIDLRGNNF
|.|.|.|..| .|||| ........| .|.| .| .. ...|.   | .|| ..|.||..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 321-361 8.3e-10 28.0 Pfam-A 2-41 (44) alignment 
Range on Protein: 321-361
Range on HMM: 2-41/44.0
NVKTLILDCNMIKVIPGSvLGSWKSLVTLNLPHNFISDLPA
| ..| |  | || .|.. |.....| |||| .| ||||.|
nLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdlsa
LRR_4 Leucine Rich repeats (2 copies) 344-380 1.3e-08 24.2 Pfam-A 1-37 (44) alignment 
Range on Protein: 344-380
Range on HMM: 1-37/44.0
KSLVTLNLPHNFISDLPAEIVTLDNLRIIDLRGNNFE
..| .|.| .| |.|||.|.  | ||. ..| .|...
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpis
subfamily_LRR-DSP_pd Subfamily LRR-DSP 679-833 3.7e-89 292.3 In-house 103-259 (263) alignment 
Range on Protein: 679-833
Range on HMM: 103-259/263.0
EVEMTAPNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHI-LTVANFKPLYPDLFKYLII-NIDDVDEANIYQYFKEMNTFIDEGREKGGVLI
 ||    ..||...|.|||.|||||.||....|.|||.|||..|||| |.||.|.||.|.|||||.| .|.|||||.|.|.|.|.|.||.|||.|||||.
pveykqveslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGvlv

HCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLS
|||||||||.|..|.|.|.|...||.||.|..||.|.||.||.||..||||.||.|.
hcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0044763 (Phosphotyrosine protein) phosphatases II 685-832 1.2e-35 118.1 In-house 12-170 (178) alignment 
Range on Protein: 685-832
Range on HMM: 12-170/178.0
PNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLY-PDL---------FKYLIINIDDVDEANIYQYFKEMNTFIDEG--REKG
. .|  .. | .. |.. ||||.  .|... .||....|||..... ..|. ...         ..|| |.|.| .. .....| |.  ||.|   ...|
leglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekgg

GVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSrIYPNRGFLNQLKKFEKDL
 ||.||.|||.||.|  .||.|.|... ..||..   . |. |.||.|.|.||..||. |
pvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
0041856 (Phosphotyrosine protein) phosphatases II 686-831 9.2e-28 92.5 In-house 9-171 (182) alignment 
Range on Protein: 686-831
Range on HMM: 9-171/182.0
NQLIFWQSIVPDLIIDKLYLGCREC--------------AMNKSWLKDNNVTHILTVAnFKPLYPDLF-----KYLIINIDDVDEANiyqyFKEMNTFID
. | ...|...| | ..||||..                |..  .||....|.|....   . .|.|.     .|| ....| .  .    . |.. ||.
dilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfie

EGREKG-GVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRS--RIYPNRGFLNQLKKFEKD
| .|.|  ||.||.|||.|..|  .||.|.|..| ..||..   . |.   |.|| .|. ||. .|. 
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Slingshot_pd Subfamily Slingshot 689-830 8.5e-31 100.6 In-house 12-155 (169) alignment 
Range on Protein: 689-830
Range on HMM: 12-155/169.0
IFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSA
|. |   .  | | .|||    | |   ||.|.|..|| |..  .  .|. |.|| |.. | .|.....|..|  .||.. ..||  ||.||. ||||||
ilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsa

TATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
.. ||| | . .....||..   . || | ||.|||.||...| 
stviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeG
PTEN_1 691-832 1.2e-23 78.9 In-house 37-191 (196) alignment 
Range on Protein: 691-832
Range on HMM: 37-191/196.0
WQSIVPdLIIDKLYLGCRECA-MNKSWLKDNNVTHILTVANFKPL----------YPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGRE---KGGVLI
....    |...||.| .. . ... .|| ...|....... ..|          .   ..|| . |.|    .. . |.. . ||.  ..   .. ||.
srpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlV

HCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
||.||..||.|  .|| | |.   ..||...  . |... || .....|......|
HCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0049772 (Phosphotyrosine protein) phosphatases II 692-831 1.4e-28 96.0 In-house 122-272 (314) alignment 
Range on Protein: 692-831
Range on HMM: 122-272/314.0
QSIVP---------------------DLIIDKLYlgCRECAMNKSWLKdnnvthilTVANFKPLYPDL-FKYLIINIDDvDEANIYQYFKEMNTFIDEGR
  ||.                      ||.| ..  .  .|..  .||        .. . ..|...| .||| |...| ..|.. ..|.|.  ||.| .
rdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieead

EKGGVLIHCRAGVSRSAT-ATIAYIMMKNSVKFQEAFDITIKGRSrIYPNRGFLNQLKKFEKD
..| ||.||.||..|..| ...||.|... | ..||..   . |. |.||.||..||. .|. 
kggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
0046846 (Phosphotyrosine protein) phosphatases II 693-832 7.4e-25 83.1 In-house 9-172 (176) alignment 
Range on Protein: 693-832
Range on HMM: 9-172/176.0
SIVPDLIIDKLYLGCRE----------CAMNKSWLKDNNVTHILTVANFK-------PLYPDL-----FKYLIINIDDVDEANIyQYFKEMNTFIDEGRE
   .| |...|.||.|           .| .  .||....|..... . .       | |...     ..|| ....| .  .. ... |.  ||.| ..
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

KG-GVLIHCRAGVSRSATATIAYIMMK-NSVKFQEAFDITIKGRS-RIYPNRGFLNQLKKFEKDL
.|  ||.||.||..|..|  .||.... . .. .||..   . |. .. ...... .|..||. |
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP10_pd Subfamily DSP10 694-834 4.5e-34 111.6 In-house 12-155 (159) alignment 
Range on Protein: 694-834
Range on HMM: 12-155/159.0
IVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDL--FKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATI
.    ..  |.||  . | ... |.  |.|..| |..  | . .   .||  |.. |  . |. |||.|   ||.| |.||  ||.||.||.||||| .|
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

AYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLSK
||.| . ......|..   . |. | || .|. ||..|||.|.|
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_DSP8_pd Subfamily DSP8 694-833 2.2e-26 86.3 In-house 13-155 (159) alignment 
Range on Protein: 694-833
Range on HMM: 13-155/159.0
IVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLF--KYLIINIDDVDEANIYQYFKEMNTFIDEGRE-KGGVLIHCRAGVSRSATATI
. |  |...||||... ..... |........| . |  |    |   |.| . . |  . .. ..|..   |||  .. .| ||.|. || |||||  |
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLS
|||| . .....||.    . |  | ||  ||.|| ..||.| 
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0045098 (Phosphotyrosine protein) phosphatases II 694-831 7.4e-24 80.0 In-house 20-270 (278) alignment 
Range on Protein: 694-831
Range on HMM: 20-270/278.0
IVPDLIIDKLYLGCRE-----------------------------------------CAMNKSWLKDNNVTHILTV------------------------
  |. | . ||||...                                         .| .   |.....|.|...                        
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

-----------------------------ANFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGR---------------EKGGVLIHCRAGVSR
                             .......   ..|| .   .| . .|...| |.  ||.| .               ..| ||.||.|||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SATATIAYIMMKN---SVKFQEAFDITIKGRSR-IYPNRGFLNQLKKFEKD
..|  .||.|...    | ..||..   . |   . .| .....| .|. .
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_DSP6_pd Subfamily DSP6 695-833 3.9e-35 114.7 In-house 13-155 (158) alignment 
Range on Protein: 695-833
Range on HMM: 13-155/158.0
VPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLYP--DLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREK-GGVLIHCRAGVSRSATATI
.|  |.. ||||... | |   ||. .. ..| |..     .   . .||| | |.|. ..|. ..| |  .||||.|.|  .||.|| ||.||| | |.
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLS
||.| |. . ...|.|.  | .| | ||  |..||..||. |.
aylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
0043147 (Phosphotyrosine protein) phosphatases II 695-832 5e-27 90.1 In-house 18-160 (172) alignment 
Range on Protein: 695-832
Range on HMM: 18-160/172.0
VPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANF----KPLYPDLFKYLIINIDDVDEAnIYQYFKEMNTFIDE---GREKGGVLIHCRAGVSRSAT
.|| .|. ...... .|..   ||....|||... ..    ..|..  ..|| ....| .   . ... |.  ||||    ...| ||.||.|||.|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

ATIAYIMMkNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
  .||.|.  .....||..   . |. . .| .....|..||| |
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0048076 (Phosphotyrosine protein) phosphatases II 696-832 4.4e-31 102.9 In-house 4-142 (145) alignment 
Range on Protein: 696-832
Range on HMM: 4-142/145.0
PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLY-PDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYI
|. |...||||.  .|..  .|||...|..|.... ..|. .  ..|| ....| .. ...... |.  ||.| ...|  ||.||.|||.|..|  .||.
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
|....| ..||..   . |. . || |.|..|..||. |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 696-830 3.2e-30 100.1 In-house 4-142 (144) alignment 
Range on Protein: 696-830
Range on HMM: 4-142/144.0
PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDL---FKYLIINIDDVDEANIYQYFKEMNTFIDEGRE-KGGVLIHCRAGVSRSATATIA
|. |...||||.  .|..  .||....|.......  . .      ..|| ....| .  ...... |.  ||.| .| .| ||.||.|||.|..|  .|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
|.|.|. . ..||..   . |. ..||.|.|..|...||
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_MKPLT_pd Subfamily MKPLT 696-830 2.5e-28 92.6 In-house 21-158 (164) alignment 
Range on Protein: 696-830
Range on HMM: 21-158/164.0
PDLII-DKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAY
| ... |.||||  . | |.  ||| ..|||. |..  |  .|  ..|| ....|. . .. .... .. |. .  . || ||.||  |.|||...|.|.
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

IMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
..  .   ..||..   . || . |||||| || |||.
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 696-830 2.5e-28 92.6 In-house 21-158 (164) alignment 
Range on Protein: 696-830
Range on HMM: 21-158/164.0
PDLII-DKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAY
| ... |.||||  . | |.  ||| ..|||. |..  |  .|  ..|| ....|. . .. .... .. |. .  . || ||.||  |.|||...|.|.
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

IMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
..  .   ..||..   . || . |||||| || |||.
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_DSP3_pd Subfamily DSP3 697-833 1.9e-31 102.9 In-house 12-158 (162) alignment 
Range on Protein: 697-833
Range on HMM: 12-158/162.0
DLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK--------PLYPDL-FKYLIINIDDVDEANIYQYFKEMNTFIDEGR--EKGGVLIHCRAGVSRS
| . .|||.| .. |..|| ||   .||.|  |. .          | || .||| ...||| |... .||..   ||||    ..| ||.||..|||||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

ATATIAYIMMKNSVKFQEAFDiTIKGRSRIYPNRGFLNQLKKFEKDLS
||  .||.|...... .||   |.. . .|.||.|||.||......|.
atlvlayLmirrkmtlveair.tvrkkReilPneGFlkqLaeldeelk
subfamily_DSP1_pd Subfamily DSP1 698-832 2.1e-39 129.2 In-house 19-156 (163) alignment 
Range on Protein: 698-832
Range on HMM: 19-156/163.0
L-IIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIM
  |.| |||| .. | |.. ||....|.|| |..  .  ..|||.|  ....|  .|.|...|.|.  |||| ..|.| |||||.||.|||.|  .||.|
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
... |...|||| . . || | || || .||...||.|
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
PTPc_motif_SM00404 698-830 3.5e-34 112.7 In-house 4-139 (140) alignment 
Range on Protein: 698-830
Range on HMM: 4-139/140.0
LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPL--YPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIM
 | ..||||  . |.|.  || ...||.. |.....|      |..| |..|| ..... .|......||.. ..||| ||.||.|||||||| .|||.|
rilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
...... .||...  . |..| || .|..|| ..||
ryrqlslaeayefvkerRpiispnlnfvrqLieyek
0049260 (Phosphotyrosine protein) phosphatases II 698-832 1.7e-27 91.4 In-house 10-149 (152) alignment 
Range on Protein: 698-832
Range on HMM: 10-149/152.0
LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPL----YPDLFKYLIINIDDVDEANIYQYFKEMNTFIDE--GREKGGVLIHCRAGVSRSATATIA
 .|  ...|.  .| .. .||....|.|... .. .|     . ...|| ....|    .. |...... ||..   ...| ||.||.|||.|..|  .|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YIMMkNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
|.|. . |...||..   . |. ..|| |.| .|..||| |
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0036282 (Phosphotyrosine protein) phosphatases II 698-832 1.7e-22 75.4 In-house 14-169 (174) alignment 
Range on Protein: 698-832
Range on HMM: 14-169/174.0
LIIDKLYLGCRECAmNKSWLKDNNVTHILTVANFKPL----------------YPDLFKYLIINIDDVDEANIYQyFKEMNTFIDEGRE---KGGVLIHC
 | ..|..|.   | .  .||....|..... . |.|                ..  ..|| ....|  . .. . . |.  |..| ..   .| ||.||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

RAGVSRSATATIAYIMMKNSV-KFQEAFDITIKGR---SRIYPNRGFLNQLKKFEKDL
.|||.|..|  .||.|...   ....|.|.  . |   ...... ... .| .||| |
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0051082 (Phosphotyrosine protein) phosphatases II 698-827 1.4e-18 62.4 In-house 10-148 (151) alignment 
Range on Protein: 698-827
Range on HMM: 10-148/151.0
LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLY--PD-----LFKYLIINIDDVDEANIYQYFKEMNTFIDEGRE--KGGVLIHCRAGVSRSATA
 . . ||..    | .  .||......|... . .. .  |.      ...| | |.| .. .. ..|.... |... ..  .| ||.||.||..|..| 
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

TIAYIMMkNSVKFQEAFDITIKGRS-RIYPNRGFLNQLKK
 ..|.|.   | ..||..   . |   ..|| .|| ||. 
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_DSP19_pd Subfamily DSP19 699-832 1.1e-42 140.0 In-house 15-150 (152) alignment 
Range on Protein: 699-832
Range on HMM: 15-150/152.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREK-GGVLIHCRAGVSRSATATIAYIMMK
....||||  . |..|. || ...|||| || . . ..|. |.|| |.| |..|... .|.||.  ||.|.|.| | ||.||.|||||||.  |||.| |
veprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkk

NSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
......||..   . |  | || ||..|||..|. |
eelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 699-830 7.1e-37 121.2 In-house 5-141 (155) alignment 
Range on Protein: 699-830
Range on HMM: 5-141/155.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKP----LYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGR-EKGGVLIHCRAGVSRSATATIAYI
| ..||||  | ..... ||. ..||.|.|....     | .   ... |.|.| .|..| ... |...||.|.. |.| ||.|| ||||||.|. |||.
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
| |. .....|...  . ...|.|| |||.||| |||
mkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP15_pd Subfamily DSP15 699-831 3.8e-35 115.2 In-house 5-138 (151) alignment 
Range on Protein: 699-831
Range on HMM: 5-138/151.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDlFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIMMK
..  |||| .. . ..  ||..|.||||.|  | |.| .| ..|..|...|  .|.. ..||| . || . | |. .||.|| ||||||.| ..||.|  
vlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

NSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
 ......|...  . ||   || || .|||..|| 
telnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP14_pd Subfamily DSP14 699-833 3.6e-30 99.0 In-house 10-145 (157) alignment 
Range on Protein: 699-833
Range on HMM: 10-145/157.0
IIDKLYLGcRECAMNKSWLKDNNVTHILTVA-NFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIMMK
| ..|.|.    |..|. || ...|.|. |. . .    . .... . ..|  ||.....| |.   |.| ..||| .|.|| |||||||. ..||.|  
itpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmky

NSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLS
...  .||. .. . |. | || || .|| ..|| | 
eklsLreayklvksaRpiirPNvGFwkqlidyEkklk
subfamily_STYX_pd Subfamily STYX 699-830 2.3e-26 85.8 In-house 15-155 (166) alignment 
Range on Protein: 699-830
Range on HMM: 15-155/166.0
IIDKLYLGCRECAMNK--SWLKDNNVTHILTV-----ANF-KPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATAT
|.  |.||   .||.     ||.. .|||. .     ||. || .|| |.||.... |    || .|. .. .|||.  .||| ||.|  ||.||||.  
ilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

IAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
|||||    .|..|||    . |  | || || .|||..| 
iayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_STYXL1_pd Subfamily STYXL1 699-833 2.7e-25 82.4 In-house 15-154 (157) alignment 
Range on Protein: 699-833
Range on HMM: 15-154/157.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLY---PDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYI
. .|||||  . |.|..  ||  |   . |..  ..|.   .|  | | |...|..||.. . .||.  ||.. ...|  ||.    |.||||.. |||.
lPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiayl

MMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLS
| .. .....|..   | .. . |||.|..||...||.|.
myskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0037934 (Phosphotyrosine protein) phosphatases II 699-831 4e-21 71.1 In-house 42-240 (243) alignment 
Range on Protein: 699-831
Range on HMM: 42-240/243.0
IIDKLYLGCR--------ECAMNKSWLKDNNVTHILTVAN----------------------------------------------FKPLYPDLFKYLII
. ..|....           | .   |.....|.|... .                                               ..|.   ..|. .
vtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

NIDD----VDEANIYQYFKEMNTFIDE------GREKGGVLIHCRAGVSRSATATIAYIMMKN-SVKFQEAFDITIKGRSR-IYPNRGFLNQLKKFEKD
.. |     . ........|...||.|        ..| ||.||.|||.|..|  .||.|... .| ..||..   . |.  . ...... .| .... 
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 699-831 4.2e-15 51.3 In-house 22-275 (297) alignment 
Range on Protein: 699-831
Range on HMM: 22-275/297.0
IIDKLYLGCRECAMNKSWLK----------------------------------------------------------DNNVTHILTVANFKPL------
. . |.|| ...|...  |.                                                          ..|||.|... .. .|      
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

---------------------------YPDLFKYLI------------------INIDDVD----EANIYQYFKEMNTFIDEGREKGGVLIHCRAGVSRS
                           ..|   . .                  ....| .     | . ............ ...| ||.||.|||.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

ATATIAYIM--------MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
.|  .|..|        . . | . ||.    . |  . .. ... .|  .. .
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 700-831 4.7e-17 57.7 In-house 51-241 (245) alignment 
Range on Protein: 700-831
Range on HMM: 51-241/245.0
IDKLYLGCRECAMNKS----WLKDNNVTHILTVANFK-----------------------------------------------PLYPDLFKYLIINIDD
 .|....    . .      .|.....|.|... ..                                                . .   . |. ....|
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

VDEANIYQYFKEMNTFIDE---GREKGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
 ..... ... ..  |...     ..| ||.||.|||.|..|  .||.|         | ..||..   . |. . .. ... .| .....
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 702-832 1.3e-28 93.3 In-house 9-152 (154) alignment 
Range on Protein: 702-832
Range on HMM: 9-152/154.0
KLYLGCRECAMNKSWLKDNNVTHILTV-ANFKPLYPDL---------FKYLIINIDDVDEANIYQYFKEMNTFIDEGR---EKGGVLIHCRAGVSRSATA
 ||..  . |.||  |. .|...|| |    . |..|          ..|| ... |  . .| . ..    |||.     |...||.|. .||||||. 
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
 |.|.| | .. . .|. .  . |  | ||.|||.||..|||.|
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 702-830 3.7e-23 75.7 In-house 14-145 (148) alignment 
Range on Protein: 702-830
Range on HMM: 14-145/148.0
KLYLGCRECAMNKSWLKDNNVTHILTVANFKP--LYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIMMKNS
 |.|| .. |.. . ||. .||.| . .. ..  |     .|| ...|| .. .. ..|... .|... ...|. ||.|.. |||||.  ......  . 
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

VKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
|  .||...    |  . || |||.|| ..|.
vslkealalvkskrryvdpnlgfLkqLaeleq
DSPc Dual specificity phosphatase, catalytic domain 703-830 6.8e-29 95.4 Pfam-A 1-132 (133) alignment 
Range on Protein: 703-830
Range on HMM: 1-132/133.0
LYLGCRECAMnKSWLKDNNVTHILTVANFKPL----YPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIMMKN
||||  ..|. .. |.....|... |.. .|      .  ..|| | ..| .|..| ....|. .||.. ..||. ||.||.||.||||| .|||.|...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
... .||...  . ||.| || ||| || ..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 703-830 6.8e-29 95.4 In-house 1-132 (133) alignment 
Range on Protein: 703-830
Range on HMM: 1-132/133.0
LYLGCRECAMnKSWLKDNNVTHILTVANFKPL----YPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIMMKN
||||  ..|. .. |.....|... |.. .|      .  ..|| | ..| .|..| ....|. .||.. ..||. ||.||.||.||||| .|||.|...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
... .||...  . ||.| || ||| || ..|.
nlslneAyefvkerrskispnagflrqLleyer
0040439 (Phosphotyrosine protein) phosphatases II 709-831 3.1e-20 68.3 In-house 66-244 (249) alignment 
Range on Protein: 709-831
Range on HMM: 66-244/249.0
ECAMNKSWLKDNNVTHILTVANFKP--------------------------------------------LYPDLFKYLIINIDDVDEANIYQYFKEMNTF
 .. .  .|.....|.|... ....                                             ... ...| |.. |  . .. ..|...  |
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IDEGRE-------KGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
|.. |.       .| ||.|| |||.|..|  .||.|      .. | ..||..   . |. . .| ... .| .....
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0051429 (Phosphotyrosine protein) phosphatases II 711-832 2.5e-16 55.6 In-house 35-224 (272) alignment 
Range on Protein: 711-832
Range on HMM: 35-224/272.0
AMNKSWLKDNNVTHILTVANFK-------PLYPDLFKYLIINIDDVDEANIYQYF---------------------------------------------
| .  .||......|... .         ..|.  ..|| ..| | ..  | ...                                             
aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

---KEMNTFIDEGREKGGVLIHCRAGVSRSATATIAYIMMkNSVK--------------FQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
   ... ..... ...| ||.||.||..|..|.  .....   |                .|| .   . |  . .. ... .| .....|
vpqeallellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 715-831 2.6e-20 68.8 In-house 125-302 (307) alignment 
Range on Protein: 715-831
Range on HMM: 125-302/307.0
SWLKDNNVTHILTVANFKPL--------YPDL---------------------FKYLIINIDDV-----------------DEANIYQYFKEMNTFIDEG
 .|....||.|... ....|        .||                      .... ... |                   . .. ..|.|.  ||.| 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

R-------EKGGVLIHCRAGVSRSATATIAYIMMKNS--------VKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
|       ..| ||.||.|||.|..|  .||.|...         | ..||..   . |. . .| ... .| .....
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 716-831 2.1e-15 52.2 In-house 105-274 (317) alignment 
Range on Protein: 716-831
Range on HMM: 105-274/317.0
WLKDNNVTHILTVANFKPL----------------------------YPDLFKYLIINIDDV----------------DEANIYQYFKEMNTFIDEGRE-
 .....||.|... ....|                            . . .... . . |                 .. .. ......  |... || 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----KGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
    .| ||.|| |||.|..|  .||.|      .. | ..||..   . |. . .. ... .| ... .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 716-830 4.5e-12 41.5 In-house 107-274 (278) alignment 
Range on Protein: 716-830
Range on HMM: 107-274/278.0
WLKDNNVTHILTVANFK----------------------------------------------PLYPDLFKYLIINIDDVDEA-NIYQYFKEMNTFIDEG
 .....||.|... ...                                              . .     |  ... | .   .. .... ......  
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

R-EKGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
. ..| ||.||.|||.|..|  ..|..         | ..||..   . |  . ..  .. .| ....
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 717-831 1.1e-14 50.1 In-house 121-287 (297) alignment 
Range on Protein: 717-831
Range on HMM: 121-287/297.0
LKDNNVTHILTVANFKPLY--------------------------PDLFK-----------------YLIINIDDVDEANIYQYFKEMNTFIDEGR----
.....||.|... ....|                            | ..                 .. ... | .  .. ... |.  ...| .    
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

EKGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
..| ||.|| |||.|..|  .||.|      .  | ..||..   . |. . .. ... .| .....
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0047943 (Phosphotyrosine protein) phosphatases II 717-825 2.5e-10 35.7 In-house 97-264 (273) alignment 
Range on Protein: 717-825
Range on HMM: 97-264/273.0
LKDNNVTHILTVANFKPL--------YPDLFK------------------------------------------YLIINIDDV----DEANIYQYFKEMN
....||..| .. ..  |        .|.                                             ..  .. |     . . . .......
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

TFIDEGREKGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAFDITIKGRSRIYPNRGFLNQL
... . ...| |..||.|||.|..|  .....     ... | . ||.    . |  . ..  .. .|
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 717-805 3.2e-08 28.7 In-house 128-271 (308) alignment 
Range on Protein: 717-805
Range on HMM: 128-271/308.0
LKDNNVTHILTVANFKPL--------YPDLFK------------------------------------------YLIINIDDVDEANIYQYFKEMNTFID
. ..||..| .. ..           .|.  .                                          .  .|  | .  .  . . ..  ...
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

EGREKGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQEAF
. ...| ...||.|||.|..|  .....     ... | ..||.
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeav
0046845 (Phosphotyrosine protein) phosphatases II 718-810 9.5e-10 33.8 In-house 145-251 (284) alignment 
Range on Protein: 718-810
Range on HMM: 145-251/284.0
KDNNVTHILTVANF--KPLYPDLFKYLIINIDDV----DEANIYQYFKEMNTFIDEGREKGGVLIHCRAGVSRSATATIAYIMMKN--------SVKFQE
||. ... |.. |   .  .  .  . .... |     . ... ............   .| ...||.|||.|..|  .......          | ..|
kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvle

AFDITIK
|.    .
avkrlre
0051299 (Phosphotyrosine protein) phosphatases II 718-814 1.8e-08 29.7 In-house 159-267 (288) alignment 
Range on Protein: 718-814
Range on HMM: 159-267/288.0
KDNNVTHILTVAN-----FKPLYPDLFKYLIINIDdvdEANIYQYFKEMNTFIDEGRE-----KGGVLIHCRAGVSRSATATIAYIM-----MKNSVKFQ
.|. ... |.| |     ..  .     .  .|.    . .. ...... .|. . |.     .| |..||.|||.|..|  .....      .. | . 
lddytvrtlevtnldlldgdgesrtvthfhytnwp...dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvl

EAFDITIKGRSR
||.    . |  
eavkrlreqRpg
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 721-833 8.1e-19 61.2 In-house 24-142 (145) alignment 
Range on Protein: 721-833
Range on HMM: 24-142/145.0
NVTHILTVAN-----FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSR
 .. |. .|       . |. . .. |.|  .|..  .. |.| |.  ||| |.|.| ||..|| |||||| | ..|..|   .. . ||       | .
gisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrll

IYPNRGFLNQLKKFEKDLS
 |||  ||..| ..||.| 
aypnvtflknllnlekqlk
0038934 (Phosphotyrosine protein) phosphatases II 729-832 5e-15 51.1 In-house 70-176 (194) alignment 
Range on Protein: 729-832
Range on HMM: 70-176/194.0
ANFKPLYPDLFKYLIINIDD----VDEANIYQYFKEMNTFIDEGReKGGVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQ
 . . ..   ..|| . . |     . ........ ...|..|   .| |..|| ||..|..|  .||.....  . .|| ..    |  ..||...|..
YdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp.ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea

LKKFEKDL
| |. |.|
llkrykel
subfamily_PTPMT1_pd Subfamily PTPMT1 740-832 4.6e-13 44.0 In-house 75-168 (171) alignment 
Range on Protein: 740-832
Range on HMM: 75-168/171.0
KYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
..| ... |. ||   .  ..   ||.. ..||  | .||.|| .||||  ..|.|.|. .. .|| ..  | |. |  ..  ...|...|. |
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
PTPc_DSPc_SM00012 752-807 1.3e-08 30.4 In-house 20-75 (105) alignment 
Range on Protein: 752-807
Range on HMM: 20-75/105.0
ANIYQYFKEMNTFIDEGREKGGVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDI
 .| .........  .  ... |..||.|||.|..| . ..|....  | .. .||
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdi
subfamily_MSG5_pd Subfamily MSG5 767-834 1.4e-11 37.8 In-house 94-162 (165) alignment 
Range on Protein: 767-834
Range on HMM: 94-162/165.0
EGREKG-GVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDLSK
  . |.  .|.||. |.||||.  .||||   .. ...|.|        | |. |.. || ..|  |||
aatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalsk