Gene mpl2 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily LRR-DSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP017_AA protein Get Run
DdisP017_AA_554-694 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
LRR_8 Leucine rich repeat 101-152 8.1e-11 31.2 Pfam-A 2-55 (61) alignment 
Range on Protein: 101-152
Range on HMM: 2-55/61.0
SLKSLILDFNKITEIPDCITL-LPNLNHLSLAANQLTHVPE-FLSQLKSLETFE
.||.|.|..|....||. .   |.|| .|.|  | |.....  ...|.||.   
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLn
LRR_4 Leucine Rich repeats (2 copies) 123-161 3.4e-08 22.9 Pfam-A 1-39 (44) alignment 
Range on Protein: 123-161
Range on HMM: 1-39/44.0
PNLNHLSLAANQLTHVPEFLSQLKSLETFEIGINQFTCF
.|| .|.|. |... .|. |..|..|.|  .  |... .
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdl
LRR_4 Leucine Rich repeats (2 copies) 169-208 5e-08 22.4 Pfam-A 1-40 (44) alignment 
Range on Protein: 169-208
Range on HMM: 1-40/44.0
KSLTSLHLETNNIKSLPEEFLNLVNLKDLSLFDNQLKEIP
..|..| |  ||||.||.|. || ||| |.|  |.. ...
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 170-225 4.5e-07 19.2 Pfam-A 2-61 (61) alignment 
Range on Protein: 170-225
Range on HMM: 2-61/61.0
SLTSLHLETNNIKSLPEEFLN-LVNLKDLSLFDNQLKEIPDSL---PNNIEKLNLGCNDI
.|..|.|  |..|..|..... | ||| |.|  | ||.|.. .    .....|||  |..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 193-227 8.5e-06 15.2 Pfam-A 2-38 (44) alignment 
Range on Protein: 193-227
Range on HMM: 2-38/44.0
NLKDLSLFDNQLKEIPDSLP--NNIEKLNLGCNDISS
||. |.| .|..|..| .|   .| . |||  | ||.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisd
LRR_8 Leucine rich repeat 214-264 4.1e-06 16.1 Pfam-A 2-52 (61) alignment 
Range on Protein: 214-264
Range on HMM: 2-52/61.0
NIEKLNLGCNDISSSKSDSLIRIsHSLTTLNLSENKIEELD-ESLSCLVNVK
|...|.| .|....   .|. .  ..|..|.||.|...... |....|....
nLkeLdLsnNrlkviptgsFkgl.snLkvLdLsgnnlksispeafkgLpsLr
LRR_4 Leucine Rich repeats (2 copies) 239-273 1.4e-08 24.1 Pfam-A 2-36 (44) alignment 
Range on Protein: 239-273
Range on HMM: 2-36/44.0
SLTTLNLSENKIEELDESLSCLVNVKTLMLDCNMI
.|..|.||.|.|..|...|. | | ||| |. | |
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpi
LRR_8 Leucine rich repeat 262-320 6.5e-12 34.7 Pfam-A 2-61 (61) alignment 
Range on Protein: 262-320
Range on HMM: 2-61/61.0
NVKTLMLDCNMIKVIPGSVLGSWKSLVTLNLPHNLISDLPPEV-ILLSNLRIIDLRGNNF
|.|.|.|..| .|||| ........| .|.| .| .. ..||.   | .|| ..|.||..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 262-302 1.4e-09 27.3 Pfam-A 2-41 (44) alignment 
Range on Protein: 262-302
Range on HMM: 2-41/44.0
NVKTLMLDCNMIKVIPGSvLGSWKSLVTLNLPHNLISDLPP
| ..| |  | || .|.. |.....| |||| .| ||||..
nLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdlsa
LRR_4 Leucine Rich repeats (2 copies) 285-326 5.3e-09 25.5 Pfam-A 1-42 (44) alignment 
Range on Protein: 285-326
Range on HMM: 1-42/44.0
KSLVTLNLPHNLISDLPPEVILLSNLRIIDLRGNNFENCKKL
..| .|.| .| |.|||||.  |.||. ..| .|...... |
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsaL
subfamily_DSP8_pd Subfamily DSP8 538-693 4.7e-26 85.2 In-house 14-154 (159) alignment 
Range on Protein: 538-693
Range on HMM: 14-154/159.0
KvevemivpnqlifwqsivPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLF--KYLIINIEDVDEANIYQHFKEMNAFIDEGRE-KGG
.                  |  |...||||... ..... |........| . |  |    |   |.| . ..|  . .. . |..   |||  .. .| 
g..................ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengr

VLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
||.|. || ||||.  .|.|| . .....||.    . || | ||. |..|| ..||.|
vlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 540-695 2.3e-89 292.9 In-house 103-260 (263) alignment 
Range on Protein: 540-695
Range on HMM: 103-260/263.0
EVEMIVPNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHI-LTVANFKPLYPDLFKYLII-NIEDVDEANIYQHFKEMNAFIDEGREKGGVLI
 ||    ..||...|.|||.|||||.||....|.|||.|||..|||| |.||.|.||.|.|||||.| .|||||||.|.|||.|.||||.|||.|||||.
pveykqveslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGvlv

HCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLFK
|||||||||........|.|..|||.||.|..||.||||.||.||..||||.||.||.
hcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
0044763 (Phosphotyrosine protein) phosphatases II 546-694 3.3e-35 116.7 In-house 12-171 (178) alignment 
Range on Protein: 546-694
Range on HMM: 12-171/178.0
PNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLY-PDL---------FKYLIINIEDVDEANIYQHFKEMNAFIDEG--REKG
. .|  .. | .. |.. ||||.  .|... .||....|||..... ..|. ...         ..|| |.|.| .. ....|| |. .||.|   ...|
leglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekgg

GVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPrIYPNIGFINQLKKFEKDLF
 ||.||.|||.||..  .|..|.|..| ..||..   . || |.|| |...||..||. |.
pvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0041856 (Phosphotyrosine protein) phosphatases II 547-694 1.2e-26 88.9 In-house 9-173 (182) alignment 
Range on Protein: 547-694
Range on HMM: 9-173/182.0
NQLIFWQSIVPDLIIDKLYLGCREC--------------AMNKSWLKDNNVTHILTVAnFKPLYPDLF-----KYLIINIEDVDEANiyqhFKEMNAFID
. | ...|...| | ..||||..                |..  .||....|.|....   . .|.|.     .|| ....| .  .    . |...||.
dilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfie

EGREKGG-VLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRP--RIYPNIGFINQLKKFEKDLF
| .|.|| ||.||.|||.|...  .|..|.|... ..||..   . ||   |.|| .|. ||. .|. |.
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Slingshot_pd Subfamily Slingshot 549-690 1.1e-29 97.0 In-house 11-154 (169) alignment 
Range on Protein: 549-690
Range on HMM: 11-154/169.0
LIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRS
.|. |   .  | | .|||    | |   ||.|.|..|| |..  .  .|. |.|| |.. | .|........|   ||.. ..||  ||.||. |||||
vilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrs

ASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFE
||. .|. | . .|...||..   . |  | || ||..||...|
astviayamkeyglsleealeyvkerrsvikPnkgflkqleeye
PTEN_1 550-694 1.9e-23 78.3 In-house 35-192 (196) alignment 
Range on Protein: 550-694
Range on HMM: 35-192/196.0
IFWQSIVPdLIIDKLYLGCRECA-MNKSWLKDNNVTHILTVANFKPL----------YPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGRE---KGGV
......    |...||.| .. . ... .|| ...|....... ..|          .   ..|| . |||    .. ..|.. . ||.  ..   .. |
apsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvV

LIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
|.||.||..||.   .|. | |. | ..||...  . ||.. ||... ..|......|.
lVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0049772 (Phosphotyrosine protein) phosphatases II 552-692 8e-28 93.5 In-house 121-272 (314) alignment 
Range on Protein: 552-692
Range on HMM: 121-272/314.0
WQSIVP---------------------DLIIDKLYlgCRECAMNKSWLKdnnvthilTVANFKPLYPDL-FKYLIINIEDvDEANIYQHFKEMNAFIDEG
.  ||.                      ||.| ..  .  .|..  .||        .. . ..|...| .||| |...| ..|.. ..|.|. .||.| 
vrdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea

REKGGVLIHCRAGVSRSAS-ATMAFIMMKNSLKFQEAFDITIKGRPrIYPNIGFINQLKKFEKD
...| ||.||.||..|... ...|..|... . ..||..   . || |.|| |||.||. .|. 
dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
subfamily_DSP10_pd Subfamily DSP10 554-694 1.9e-33 109.6 In-house 11-154 (159) alignment 
Range on Protein: 554-694
Range on HMM: 11-154/159.0
SIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDL--FKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASAT
..    ..  |.||  . | ... |.  |.|..| |..  | . .   .||  |...|  . |. |.|.|  .||.| |.||  ||.||.||.||||. .
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

MAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
.|..| . .|....|..   . || | ||..|. ||..|||.| 
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
0046846 (Phosphotyrosine protein) phosphatases II 554-694 5.3e-24 80.3 In-house 9-173 (176) alignment 
Range on Protein: 554-694
Range on HMM: 9-173/176.0
SIVPDLIIDKLYLGCRE----------CAMNKSWLKDNNVTHILTVANFK-------PLYPDL-----FKYLIINIEDVDEANIyQHFKEMNAFIDEGRE
   .| |...|.||.|           .| .  .||....|..... . .       | |...     ..|| ....| .  .. ... |. .||.| ..
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

KG-GVLIHCRAGVSRSASATMAFIMMK-NSLKFQEAFDITIKGRP-RIYPNIGFINQLKKFEKDLF
.|  ||.||.||..|..   .|..... . |. .||..   . || .. .. ... .|..||. |.
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 555-693 4.6e-26 87.0 In-house 17-160 (172) alignment 
Range on Protein: 555-693
Range on HMM: 17-160/172.0
IVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANF----KPLYPDLFKYLIINIEDVDEAnIYQHFKEMNAFIDE---GREKGGVLIHCRAGVSRSA
..|| .|. ...... .|..   ||....|||... ..    ..|..  ..|| ....| .   . ... |.  ||||    ...| ||.||.|||.|..
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg

SATMAFIMMkNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
   .|..|.  .|...||..   . || . .| .....|..||| |
tlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0045098 (Phosphotyrosine protein) phosphatases II 555-694 1.7e-23 78.9 In-house 20-272 (278) alignment 
Range on Protein: 555-694
Range on HMM: 20-272/278.0
IVPDLIIDKLYLGCRE-----------------------------------------CAMNKSWLKDNNVTHILTV------------------------
  |. | . ||||...                                         .| .   |.....|.|...                        
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

-----------------------------ANFKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGR---------------EKGGVLIHCRAGVSR
                             .......   ..|| .   .| . .|...| |.  ||.| .               ..| ||.||.|||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SASATMAFIMMKN---SLKFQEAFDITIKGRPR-IYPNIGFINQLKKFEKDLF
..   .|..|...    . ..||..   . ||  . .| .....| .|. .|.
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_DSP6_pd Subfamily DSP6 556-693 1.9e-33 109.2 In-house 13-154 (158) alignment 
Range on Protein: 556-693
Range on HMM: 13-154/158.0
VPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLYP--DLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREK-GGVLIHCRAGVSRSASATM
.|  |.. ||||... | |   ||. .. ..| |..     .   . .||| | |||. ..|. ..| |  .||||.|.|  .||.|| ||.|||   |.
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
|..| |. | ...|.|.  | .. | ||  |..||..||. |
aylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0048076 (Phosphotyrosine protein) phosphatases II 557-693 2.2e-30 100.6 In-house 4-142 (145) alignment 
Range on Protein: 557-693
Range on HMM: 4-142/145.0
PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLY-PDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFI
|. |...||||.  .|..  .|||...|..|.... ..|. .  ..|| ....| .. ...... |. .||.| ...|  ||.||.|||.|...  .|..
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
|..... ..||..   . || . || |....|..||. |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 557-691 2.1e-29 97.5 In-house 4-142 (144) alignment 
Range on Protein: 557-691
Range on HMM: 4-142/144.0
PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDL---FKYLIINIEDVDEANIYQHFKEMNAFIDEGRE-KGGVLIHCRAGVSRSASATMA
|. |...||||.  .|..  .||....|.......  . .      ..|| ....| .  ...... |. .||.| .| .| ||.||.|||.|...  .|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

FIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
..|.|. | ..||..   . || ..|| |....|...||
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_MKPLT_pd Subfamily MKPLT 557-691 1.9e-25 83.3 In-house 21-158 (164) alignment 
Range on Protein: 557-691
Range on HMM: 21-158/164.0
PDLII-DKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAF
| ... |.||||  . | |.  ||| ..|||. |..  |  .|  ..|| ...||. . .. .... .. |. .  . || ||.||  |.|||.|.|.||
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

IMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
..  .   ..||..   . |  . || ||. || |||.
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 557-691 1.9e-25 83.3 In-house 21-158 (164) alignment 
Range on Protein: 557-691
Range on HMM: 21-158/164.0
PDLII-DKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAF
| ... |.||||  . | |.  ||| ..|||. |..  |  .|  ..|| ...||. . .. .... .. |. .  . || ||.||  |.|||.|.|.||
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

IMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
..  .   ..||..   . |  . || ||. || |||.
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_DSP3_pd Subfamily DSP3 558-694 1.6e-28 93.4 In-house 12-158 (162) alignment 
Range on Protein: 558-694
Range on HMM: 12-158/162.0
DLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK--------PLYPDL-FKYLIINIEDVDEANIYQHFKEMNAFIDEGR--EKGGVLIHCRAGVSRS
| . .|||.| .. |..|| ||   .||.|  |. .          | || .||| ....|| |... ..|..  .||||    ..| ||.||..|||||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

ASATMAFIMMKNSLKFQEAFDiTIKGRPRIYPNIGFINQLKKFEKDLF
|   .|..|...... .||   |.. . .|.|| ||..||......| 
atlvlayLmirrkmtlveair.tvrkkReilPneGFlkqLaeldeelk
subfamily_DSP1_pd Subfamily DSP1 559-693 3.8e-39 128.4 In-house 19-156 (163) alignment 
Range on Protein: 559-693
Range on HMM: 19-156/163.0
L-IIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIM
  |.| |||| .. | |.. ||....|.|| |..  .  ..|||.|  ...||  .|.|...|.|.  |||| ..|.| |||||.||.|||..  .|..|
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
... ....|||| . . |. | ||.||..||...||.|
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
PTPc_motif_SM00404 559-691 7.4e-33 108.4 In-house 4-139 (140) alignment 
Range on Protein: 559-691
Range on HMM: 4-139/140.0
LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPL--YPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIM
 | ..||||  . |.|.  || ...||.. |.....|      |..| |...| ..... ........||.. ..||| ||.||.|||||||. ..|..|
rilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
....|. .||...  . ||.| ||..|..|| ..||
ryrqlslaeayefvkerRpiispnlnfvrqLieyek
0049260 (Phosphotyrosine protein) phosphatases II 559-692 6.8e-26 86.2 In-house 10-148 (152) alignment 
Range on Protein: 559-692
Range on HMM: 10-148/152.0
LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPL----YPDLFKYLIINIEDVDEANIYQHFKEMNAFIDE--GREKGGVLIHCRAGVSRSASATMA
 .|  ...|.  .| .. .||....|.|... .. .|     . ...|| ....|    .. |...... ||..   ...| ||.||.|||.|..   .|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

FIMMkNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKD
..|. . ....||..   . || ..|| |.. .|..||| 
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0036282 (Phosphotyrosine protein) phosphatases II 559-691 2.7e-21 71.5 In-house 14-167 (174) alignment 
Range on Protein: 559-691
Range on HMM: 14-167/174.0
LIIDKLYLGCRECAmNKSWLKDNNVTHILTVANFKPL----------------YPDLFKYLIINIEDVDEANIYQhFKEMNAFIDEGRE---KGGVLIHC
 | ..|..|.   | .  .||....|..... . |.|                ..  ..|| ....|  . .. . . |.  |..| ..   .| ||.||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

RAGVSRSASATMAFIMMKNSL-KFQEAFDITIKGR---PRIYPNIGFINQLKKFEK
.|||.|..   .|..|... | ....|.|.  . |   |..... ... .| .|||
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0051082 (Phosphotyrosine protein) phosphatases II 559-688 9.9e-18 59.6 In-house 10-148 (151) alignment 
Range on Protein: 559-688
Range on HMM: 10-148/151.0
LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLY--PD-----LFKYLIINIEDVDEANIYQHFKEMNAFIDEGRE--KGGVLIHCRAGVSRSASA
 . . ||..    | .  .||......|... . .. .  |.      ...| | |.| .. .. ..|.....|... ..  .| ||.||.||..|..  
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

TMAFIMMkNSLKFQEAFDITIKGRP-RIYPNIGFINQLKK
 ....|.   . ..||..   . ||  ..|| .|. ||. 
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_DSP19_pd Subfamily DSP19 560-693 4.1e-43 141.3 In-house 15-150 (152) alignment 
Range on Protein: 560-693
Range on HMM: 15-150/152.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREK-GGVLIHCRAGVSRSASATMAFIMMK
....||||  . |..|. || ...|||| || . . ..|. |.|| |.| |..|... ...||.  ||.|.|.| | ||.||.||||||||  .|..| |
veprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkk

NSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
..|...||..   . || | || |||.|||..|. |
eelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 560-691 3.8e-36 118.8 In-house 5-141 (155) alignment 
Range on Protein: 560-691
Range on HMM: 5-141/155.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKP----LYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGR-EKGGVLIHCRAGVSRSASATMAFI
| ..||||  | ..... ||. ..||.|.|....     | .   ... |.| | .|..| .|. |...||.|.. |.| ||.|| ||||||... .|..
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
| |. |....|...  . .|.|.|| ||..||| |||
mkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP15_pd Subfamily DSP15 560-691 5.3e-33 108.2 In-house 5-137 (151) alignment 
Range on Protein: 560-691
Range on HMM: 5-137/151.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDlFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMMK
..  |||| .. . ..  ||..|.||||.|  | |.| .| ..|..|...|  .|.. ..||| . || . | |. .||.|| ||||||.  ..|..|  
vlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

NSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
 .|....|...  . |    ||.|| .|||..||
telnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP14_pd Subfamily DSP14 560-694 3.2e-31 102.4 In-house 10-145 (157) alignment 
Range on Protein: 560-694
Range on HMM: 10-145/157.0
IIDKLYLGcRECAMNKSWLKDNNVTHILTVA-NFKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIMMK
| ..|.|.    |..|. || ...|.|. |. . .    . .... . .||  ||....|| |. . |.| ..||| .|.|| |||||||| ..|..|  
itpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmky

NSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
..|  .||. .. . || | ||.|| .|| ..|| |.
eklsLreayklvksaRpiirPNvGFwkqlidyEkklk
subfamily_STYX_pd Subfamily STYX 560-691 3.9e-25 81.9 In-house 15-155 (166) alignment 
Range on Protein: 560-691
Range on HMM: 15-155/166.0
IIDKLYLGCRECAMNK--SWLKDNNVTHILTV-----ANF-KPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASAT
|.  |.||   .||.     ||.. .|||. .     ||. || .|| |.||.... |    || ... .. .|||.  .||| ||.|  ||.||||.  
ilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

MAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
.|.||    ||..|||    . |  | || ||..|||..| 
iayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_STYXL1_pd Subfamily STYXL1 560-694 6.9e-24 77.8 In-house 15-154 (157) alignment 
Range on Protein: 560-694
Range on HMM: 15-154/157.0
IIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLY---PDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFI
. .|||||  . |.|..  ||  |   . |..  ..|.   .|  | | |..||..||.. ...||.  ||.. ...|  ||.    |.||||.. .|..
lPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiayl

MMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
| .. .....|..   | .. . || .|..||...||.|.
myskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0037934 (Phosphotyrosine protein) phosphatases II 560-694 2.2e-20 68.7 In-house 42-242 (243) alignment 
Range on Protein: 560-694
Range on HMM: 42-242/243.0
IIDKLYLGCR--------ECAMNKSWLKDNNVTHILTVAN----------------------------------------------FKPLYPDLFKYLII
. ..|....           | .   |.....|.|... .                                               ..|.   ..|. .
vtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

NIED----VDEANIYQHFKEMNAFIDE------GREKGGVLIHCRAGVSRSASATMAFIMMKN-SLKFQEAFDITIKGRPR-IYPNIGFINQLKKFEKDL
.. |     . ........|...||.|        ..| ||.||.|||.|..   .|..|... .. ..||..   . ||  . .. ... .| .... |
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel

F
.
l
0036941 (Phosphotyrosine protein) phosphatases II 560-694 4e-14 48.1 In-house 22-277 (297) alignment 
Range on Protein: 560-694
Range on HMM: 22-277/297.0
IIDKLYLGCRECAMNKSWLK----------------------------------------------------------DNNVTHILTVANFKPL------
. . |.|| ...|...  |.                                                          ..|||.|... .. .|      
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

--YPDL------------------------FKYLIINIED----------------VDEANIYQHFKEMNAFIDEGR-------EKGGVLIHCRAGVSRS
  .|.                         ...  . ..|                 .. .. ...... .||.. |       ..| ||.||.|||.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

ASATMAFIM--------MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
..  .|..|        . . . . ||.    . || . .. ..  .|  .. .|.
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 561-694 1.2e-16 56.4 In-house 51-243 (245) alignment 
Range on Protein: 561-694
Range on HMM: 51-243/245.0
IDKLYLGCRECAMNKS----WLKDNNVTHILTVANFK-----------------------------------------------PLYPDLFKYLIINIED
 .|....    . .      .|.....|.|... ..                                                . .   . |. ....|
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

VDEANIYQHFKEMNAFIDE---GREKGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
 ..... ... ..  |...     ..| ||.||.|||.|..   .|..|         . ..||..   . || . .. ... .| .....|.
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 563-693 4.6e-27 88.3 In-house 9-152 (154) alignment 
Range on Protein: 563-693
Range on HMM: 9-152/154.0
KLYLGCRECAMNKSWLKDNNVTHILTV-ANFKPLYPDL---------FKYLIINIEDVDEANIYQHFKEMNAFIDEGR---EKGGVLIHCRAGVSRSASA
 ||..  . |.||  |. .|...|| |    . |..|          ..|| ... |  . .| ....    |||.     |...||.|. .||||||. 
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
 ....| | .. . .|. .  . |. | || ||..||..|||.|
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 563-691 1.9e-21 70.1 In-house 14-145 (148) alignment 
Range on Protein: 563-691
Range on HMM: 14-145/148.0
KLYLGCRECAMNKSWLKDNNVTHILTVANFKP--LYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIMMKNS
 |.|| .. |.. . ||. .||.| . .. ..  |     .|| ....| .. .. . |... ||... ...|. ||.|.. |||||.  ......  . 
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

LKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
   .||...    |. . || ||..|| ..|.
vslkealalvkskrryvdpnlgfLkqLaeleq
DSPc Dual specificity phosphatase, catalytic domain 564-691 2e-28 93.9 Pfam-A 1-132 (133) alignment 
Range on Protein: 564-691
Range on HMM: 1-132/133.0
LYLGCRECAMnKSWLKDNNVTHILTVANFKPL----YPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIMMKN
||||  ..|. .. |.....|... |.. .|      .  ..|| | .|| .|..| ....|. .||.. ..||. ||.||.||.||||. ..|..|...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
.|. .||...  . |..| ||.||. || ..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 564-691 2e-28 93.9 In-house 1-132 (133) alignment 
Range on Protein: 564-691
Range on HMM: 1-132/133.0
LYLGCRECAMnKSWLKDNNVTHILTVANFKPL----YPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIMMKN
||||  ..|. .. |.....|... |.. .|      .  ..|| | .|| .|..| ....|. .||.. ..||. ||.||.||.||||. ..|..|...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK
.|. .||...  . |..| ||.||. || ..|.
nlslneAyefvkerrskispnagflrqLleyer
0040439 (Phosphotyrosine protein) phosphatases II 570-694 8.9e-20 66.8 In-house 66-246 (249) alignment 
Range on Protein: 570-694
Range on HMM: 66-246/249.0
ECAMNKSWLKDNNVTHILTVANFKP--------------------------------------------LYPDLFKYLIINIEDVDEANIYQHFKEMNAF
 .. .  .|.....|.|... ....                                             ... ...| |.. |  . .. ..|... .|
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IDEGRE-------KGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
|.. |.       .| ||.|| |||.|..   .|..|      .. . ..||..   . || . .| ... .| .....|.
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0051429 (Phosphotyrosine protein) phosphatases II 572-694 2.5e-16 55.6 In-house 35-225 (272) alignment 
Range on Protein: 572-694
Range on HMM: 35-225/272.0
AMNKSWLKDNNVTHILTVANFK-------PLYPDLFKYLIINIEDVDEANIYQHF---------------------------------------------
| .  .||......|... .         ..|.  ..|| ..|.| ..  | ...                                             
aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

---KEMNAFIDEGREKGGVLIHCRAGVSRSASATMAFIMMkNSLK--------------FQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
   ... ..... ...| ||.||.||..|.. . ......   .                .|| .   . || . .. ... .| .....|.
vpqeallellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 576-694 5.1e-20 67.9 In-house 125-304 (307) alignment 
Range on Protein: 576-694
Range on HMM: 125-304/307.0
SWLKDNNVTHILTVANFKPL--------YPDL---------------------FKYLIINIEDV-----------------DEANIYQHFKEMNAFIDEG
 .|....||.|... ....|        .||                      .... ....|                   . .. ..|.|. .||.| 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

R-------EKGGVLIHCRAGVSRSASATMAFIMMKNS--------LKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
|       ..| ||.||.|||.|...  .|..|...         . ..||..   . || . .| ... .| .....|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 577-694 6e-16 54.0 In-house 105-276 (317) alignment 
Range on Protein: 577-694
Range on HMM: 105-276/317.0
WLKDNNVTHILTVANFKPL----------------------------YPDLFKYLIINIEDV----------------DEANIYQHFKEMNAFIDEGRE-
 .....||.|... ....|                            . . .... . .||                 .. .. ...... .|... || 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----KGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
    .| ||.|| |||.|...  .|..|      .. . ..||..   . || . .. ... .| ... ...
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 577-694 1.7e-11 39.6 In-house 107-277 (278) alignment 
Range on Protein: 577-694
Range on HMM: 107-277/278.0
WLKDNNVTHILTVANFK----------------------------------------------PLYPDLFKYLIINIEDVDEA-NIYQHFKEMNAFIDEG
 .....||.|... ...                                              . .     |  ... | .   .. .... ..|...  
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

R-EKGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
. ..| ||.||.|||.|..   .....         . ..||..   . || . ..  .. .| .......
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 578-694 1.8e-14 49.4 In-house 121-289 (297) alignment 
Range on Protein: 578-694
Range on HMM: 121-289/297.0
LKDNNVTHILTVANFKPL--------------------------YPDLFK-----------------YLIINIEDVDEANIYQHFKEMNAFIDEGR----
.....||.|... ....|                          . | ..                 .. ... | .  .. ... |.  ...| .    
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

EKGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDLF
..| ||.|| |||.|...  .|..|      .  . ..||..   . || . .. ... .| .....|.
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0047943 (Phosphotyrosine protein) phosphatases II 578-686 4.2e-09 31.7 In-house 97-264 (273) alignment 
Range on Protein: 578-686
Range on HMM: 97-264/273.0
LKDNNVTHILTVANFKPL--------YPDLFK------------------------------------------YLIINIEDV----DEANIYQHFKEMN
....||..| .. ..  |        .|.                                             ..  .. |     . . . . .....
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

AFIDEGREKGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPNIGFINQL
 .. . ...| |..||.|||.|...  .....     ... . . ||.    . || . ..  .. .|
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 578-674 4.3e-07 25.0 In-house 128-279 (308) alignment 
Range on Protein: 578-674
Range on HMM: 128-279/308.0
LKDNNVTHILTVANFKPL--------YPDLFK------------------------------------------YLIINIEDVDEANIYQHFKEMNAFID
. ..||..| .. ..           .|.  .                                          .  .| .| .  .  ... ..  ...
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

EGREKGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRP
. ...| ...||.|||.|..   .. ..     ... . ..||.    . ||
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
0051299 (Phosphotyrosine protein) phosphatases II 580-679 2.5e-07 25.9 In-house 114-271 (288) alignment 
Range on Protein: 580-679
Range on HMM: 114-271/288.0
DNNVTHILTVAN---------------------------------------------------FKPLYPDLFKYLIINIEdvdEANIYQHFKEMNAFIDE
..||..| .. .                                                   ..  .     .  .|.    . .. ...... .|. .
eqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp...dhgvpdspellldflrl

GRE-----KGGVLIHCRAGVSRSASATMAFIM-----MKNSLKFQEAFDITIKGRPRIYPN
 |.     .| |..||.|||.|..   .....      .. . . ||.    . || . ..
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 581-693 1.7e-20 66.6 In-house 23-141 (145) alignment 
Range on Protein: 581-693
Range on HMM: 23-141/145.0
NNVTHILTVAN-----FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRP
  .. |. .|       . |. . .. |.|  ||..  .. ||| |.  ||| |.|.| ||..|| |||||| . ..||.|   .. . ||       | 
lgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrl

RIYPNIGFINQLKKFEKDL
. |||. |...| ..||.|
laypnvtflknllnlekql
0046845 (Phosphotyrosine protein) phosphatases II 585-675 4.4e-08 28.3 In-house 151-255 (284) alignment 
Range on Protein: 585-675
Range on HMM: 151-255/284.0
HILTVANF--KPLYPDLFKYLIINIEDV----DEANIYQHFKEMNAFIDEGREKGGVLIHCRAGVSRSASATMAFIMMKN--------SLKFQEAFDITI
. |.. |   .  .  .  . .... |     . ... . ..... ....   .| ...||.|||.|..   .. ....          . ..||.    
rtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlr

KGRPR
. || 
eqRpg
0038934 (Phosphotyrosine protein) phosphatases II 590-693 1.1e-13 46.7 In-house 70-176 (194) alignment 
Range on Protein: 590-693
Range on HMM: 70-176/194.0
ANFKPLYPDLFKYLIINIEDV----DEANIYQHFKEMNAFIDEGrEKGGVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQ
 . . ..   ..|| . ..|     . ..... .. .. |..|  ..| |..|| ||..|..    |...... .. .|| ..    || ..||......
YdpeefekagieylklpfpddgtvPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea

LKKFEKDL
| |. |.|
llkrykel
subfamily_PTPMT1_pd Subfamily PTPMT1 601-693 1.1e-11 39.5 In-house 75-168 (171) alignment 
Range on Protein: 601-693
Range on HMM: 75-168/171.0
KYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL
..| ... |. ||   .. ..   ||.. ..||  | .||.|| .|||.   ...|.|. |. .|| ..  | |. |  .    ..|...|. |
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_MSG5_pd Subfamily MSG5 612-692 3.5e-12 39.7 In-house 78-159 (165) alignment 
Range on Protein: 612-692
Range on HMM: 78-159/165.0
EANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKD
...| . . ..   |   . |.  .|.||. |.|||||  .|.||   .| ...|.|        | |.||.| || ..|  
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
PTPc_DSPc_SM00012 613-668 1.1e-07 27.3 In-house 20-75 (105) alignment 
Range on Protein: 613-668
Range on HMM: 20-75/105.0
ANIYQHFKEMNAFIDEGREKGGVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDI
 .| ....... .  .  ... |..||.|||.|..  ... |....  | .. .||
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdi