Gene DDB_G0272662 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP019_AA protein Get Run
DdisP019_AA_9-157 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 7-145 6.2e-22 73.8 In-house 98-286 (308) alignment 
Range on Protein: 7-145
Range on HMM: 98-286/308.0
HIETIIESSTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINY----------------DASLFEGVK----------------------------
.. . .  ...|||..  |...|.  |  .. .. .  ||. ... .                .   .....                            
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

----IHELCFKDGNVPPK-DIIERWLEILKQAFiengkQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSPQ
    .| .  .|..|||. .|. ..||.... .     .. .. .|| ||.|||  .... |.      | |. ...|| ..|..| .....|.
tvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
subfamily_PRL_pd Subfamily PRL 9-157 2.8e-66 216.2 In-house 2-150 (151) alignment 
Range on Protein: 9-157
Range on HMM: 2-150/151.0
ETIIESSTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKQktTVGIHCIA
|..||.....|...|.||..|...|.. .||... ..||.||..||.. .|  |.....|.|.||.|||....|.|||.||..| |..|.  ||..||.|
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepks..tvavhcva

GLGRTPLLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKASKK
||||.|.||..||||.|||. .||||.|.||..|||| |.|||..|||.||
GlGraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0045098 (Phosphotyrosine protein) phosphatases II 11-152 4.9e-28 93.7 In-house 62-267 (278) alignment 
Range on Protein: 11-152
Range on HMM: 62-267/278.0
IiessTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDA----------------------------------------------SLF--EGVK
     ..|||... |...|.  | ...... .  ||...|  ...                                              . .   ||.
y....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvt

IHEL-CFKDGNVPPKDIIERWLEILKQAFIENGK-------------QKTTVGIHCIAGLGRTPLLVCIALIED----GMKPLQAVEFVRSKRKN-AI-N
.. . .. |..||. .|.  .||.|..    . .             ....| .|| ||.|||  ||.. |. .    |. .|.||...||.| . |. |
hlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqn

SPQIKFLKEY
  |..|| |.
leqyrflyef
0043147 (Phosphotyrosine protein) phosphatases II 15-152 5.1e-29 96.6 In-house 18-156 (172) alignment 
Range on Protein: 15-152
Range on HMM: 18-156/172.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAFieNGKQKTTVGIHCIAGLGRTP
 ...|| .  |. .|.. | ...|.. .  ||...|  ||..|.|  |.... | . |..||. ......||......  . ... .| .|| ||.|||.
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtg

LLVCIALIEDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
.||.. |.. |.....||..||.|| .|. |  |..||...
tlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyf
0040439 (Phosphotyrosine protein) phosphatases II 15-152 1.6e-25 85.6 In-house 52-241 (249) alignment 
Range on Protein: 15-152
Range on HMM: 52-241/249.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN---------------------------------------------YDASLFEGVKIHELCFK
....||... |..||.. | ...... .  ||....                                               || . ..   |. . . 
ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp

DGNVP-PKDIIERWLEILKQaFIENGKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
| .||   ... ...|.... ..|. .... | .|| ||.|||...... |.      | |. ...||...||.| .|. |  |..|| |.
dhgvppsfedlldfieavrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 15-152 1.8e-25 85.8 In-house 105-299 (307) alignment 
Range on Protein: 15-152
Range on HMM: 105-299/307.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDA--------------------------------------------SLFEGVKIHELCF--
...|||... |..||.  |  ..... .  ||...|  ...                                              .|. ... ...  
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

-KDGNVPPK-DIIERWLEILKQaFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDG---------MKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
  |..|||  ... ...|.... ..|. .... | .|| ||.|||. .... |. ..         . .|.||...|..| .|. |  |..|| |.
wpdhgvppsfeelldfieevrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 15-151 6.5e-25 83.6 In-house 86-271 (278) alignment 
Range on Protein: 15-151
Range on HMM: 86-271/278.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN--------------------------------------------YDASLFEGVKIHELCFKD
 ..|||..  |..||.  |  ..... .  ||. .|                                              .|   .... .| |.. |
vprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpd

GNVP-PKDIIERWLEILKQAFIengKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKE
..|| . ... ..|.....|.    .... | .|| ||.||| ..... |.      | |. ...||...|..| .|. .  |..|| |
hgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0040438 (Phosphotyrosine protein) phosphatases II 15-152 2.9e-24 81.4 In-house 84-271 (317) alignment 
Range on Protein: 15-152
Range on HMM: 84-271/317.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDA--------------------------SLFEGVKIHELCF-------------------K
 ..|||..  |...|.  |  ..... .  ||. .|  ..                              .|.....|..                    
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

DGNVPP-KDIIERWLEILKQAFiEngKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSP-QIKFLKEY
|..|||  |.. ..||....|. |  .... | .|| ||.|||  .... |.      | |. . .||...|..| .|. .| |..|| ..
dhgvppspdllldfleavreal.e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0047943 (Phosphotyrosine protein) phosphatases II 15-145 2.6e-22 75.0 In-house 75-259 (273) alignment 
Range on Protein: 15-145
Range on HMM: 75-259/273.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYD----------------ASLFEGVKI--------------------------------HEL
...|||... |...|.  | ...... .  ||. .|. ..                   .. ...                                | .
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhyt

CFKDGNVP-PKDIIERWLEILKQAFIENGKQkTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSPQ
 . | .||   ... ...|....|. .. .. ..| .|| ||.|||  .... |.      | |. .|.|| ..||.| ... .|.
gwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0051299 (Phosphotyrosine protein) phosphatases II 15-145 2e-21 72.2 In-house 90-273 (288) alignment 
Range on Protein: 15-145
Range on HMM: 90-273/288.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN-------------------------------------------------YDASLFEGVKIHE
...|||..  |...|.  |  .. .. .  ||. ...                                                  .|   ..   .| 
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

LCFKDGNVPP-KDIIERWLEILKQAFIengKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSPQ
. . | .||.  . . ..|.....|.    ... .| .|| ||.|||  .... |.      | |. .|.||...|..| .....|.
tnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 15-145 1.1e-19 66.4 In-house 75-261 (284) alignment 
Range on Protein: 15-145
Range on HMM: 75-261/284.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINY-----------------------------------------------DASLFEGVKIHELC
...|||..  |...|.  |  .. .. .  ||  .|.                                                 .   ..   .| . 
ikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyts

FKDGNVPP-KDIIERWLEILKQAFIEnGKQKTTVGIHCIAGLGRTPLLVCIALIED---------GMKPLQAVEFVRSKRKNAINSPQ
. | .|||  ... ..|....... .  ... .. .|| ||.|||  .... |. .         |. .|.|| ..|..| .......
wpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0051082 (Phosphotyrosine protein) phosphatases II 15-148 3e-19 64.5 In-house 14-143 (151) alignment 
Range on Protein: 15-148
Range on HMM: 14-143/151.0
SthkFILFDEPTEETIPYFKDlMKKNSCINIVRCCEINYDASLFEG--VKIHELCFKDGNVPPK----DIIERWLEILKQafiengKQKTTVGIHCIAGL
    ..... |... ....|. .. .. .|.    |..|......   .... . . |  .|.     |.. . ||.| .      |..  | .|| ||.
g...lyrsggpladflellke.lgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGk

GRTPLLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKF
||| .||.. |.  |. . .|.|..|.|| ......|  .
gRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqfl
0036941 (Phosphotyrosine protein) phosphatases II 15-150 1e-16 56.6 In-house 76-270 (297) alignment 
Range on Protein: 15-150
Range on HMM: 76-270/297.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDAS------------------------------LFEGVKIHELC-----------------
 ..|||.   |...|.  |  .. .. .  ||  .|   .                                |........|.                 
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhy

--FKDGNVPP-KDIIERWLEILKQAFiENGKQKTTVGIHCIAGLGRTPLLVCIAL---------IEDGMKPLQAVEFVRSKRKNAINSP-QIKFLK
    | .||.  ... ...| ....  ..  ... | .|| ||.||.  .... |         .| |. .|.|| ..|..| .|. .. | .|| 
tgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly
subfamily_VSP_pd Subfamily VSP 15-140 6.9e-11 36.5 In-house 50-173 (212) alignment 
Range on Protein: 15-140
Range on HMM: 50-173/212.0
STHKFILFDEPTEETIPYFKDlMKKNSCINIVRCCEINYDASLFEGvKIHELCFKDGNVPPKDIIERWLEILKQaFIENGkQKTTVGIHCIAGLGRTPLL
|. |  |. .| .|   ...    ..    .  | | .|| . |.  .....   | |||  . .    ...|. ..|.  .|  . |||  | |||  .
ssGkqslyrnpisevarfldt.khrdhykvvnlcseraydekyfnn.rvkriliddhnvpkleellvftkevke.wlekd.lknvlaihckGGkgrtGti

VCIALIEDGMK--PLQAVEFVRSKRKNA
||  |.. ..     .....  ..| . 
vcalllaseifetakesldyfgerrtdk
0038934 (Phosphotyrosine protein) phosphatases II 16-152 1.7e-30 101.5 In-house 17-169 (194) alignment 
Range on Protein: 16-152
Range on HMM: 17-169/194.0
THKFILFDEPTEETI----------------PYFKDLMKKNSCINIVRCCEINYDASLFEG--VKIHELCFKD-GNVPPKDIIERWLEILKQAFIENgkQ
| .|| |. |.....                 |.|.| .|. ..  ... |  ||...||.  .....| |.| |.||. .|. |.|..... . |.  .
tgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned..p

KTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRKNAInsPQIKFLKEY
. .|..|| ||||||..||. .||.  ||.. .|....|.||..||  |....|...
ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleal
0042113 (Phosphotyrosine protein) phosphatases II 16-152 9.3e-27 89.4 In-house 51-238 (245) alignment 
Range on Protein: 16-152
Range on HMM: 51-238/245.0
THKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN---------------------------------------------YDASLFEGVKIHELCFKD
|.|||... |..||.. |  ..... .  ||...|                                               .|   .|.. .| | . |
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

GNVPP-KDIIERWLEILKQAFIEngKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
..||.  ......||....|  |  .....| .|| ||.||| ..... |.      | |. . .||...||.| .|. .  |..|| |.
hgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0041856 (Phosphotyrosine protein) phosphatases II 16-156 1.8e-26 88.3 In-house 33-169 (182) alignment 
Range on Protein: 16-156
Range on HMM: 33-169/182.0
THKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFEG--VKIHELCFKDGNVPPkdiIERWLEILKQAFIengkQKTTVGIHCIAGLGRTPL
. .||..  |. .|.. | ...|.. .  ||...| .|...|.|   .... | . |..||.   .. .|......      .. .| .|| ||.|||. 
atrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle....eggpvlVHCsaGvgRtgt

LVCIALIE-DGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKASK
||.. |..  |. . .||..|||.| ... .|.  |.  ...  
lvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
0037934 (Phosphotyrosine protein) phosphatases II 16-152 1.3e-25 85.9 In-house 43-237 (243) alignment 
Range on Protein: 16-152
Range on HMM: 43-237/243.0
THKFILFDEPTEETIPY----FKDLMKKNSCINIVRCCEIN--------------------------------------------YDASLFEGVKIHELC
| ..|... |..||.      | ...... .  || ..|                                              .|   ......| |.
tprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylp

FKDGNVPP-KDIIERWLEILKQAFIE-----NGKQKTTVGIHCIAGLGRTPLLVCIALIED--GMKPLQAVEFVRSKRKN-AI-NSPQIKFLKEY
. |..||.  ... ..|.....   |     . ... .| .|| ||.||| .|... |. .  |. ...||...|..| . |. .  |..|| |.
wpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 16-152 6.6e-25 83.6 In-house 100-284 (297) alignment 
Range on Protein: 16-152
Range on HMM: 100-284/297.0
THKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDAS------------------------LFEGVK-----------------IHELCFKDGNVP
|.|||..  |..||.  |  ..... .  ||. .. ...                            .|..                 .. ... |..||
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvp

P-KDIIERWLEILKQAFIENgKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
|  ... ..||....|. |. .... | .|| ||.|||  .... |.      | |. .|.||...|..| .|. .  |..|| ..
pslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0036282 (Phosphotyrosine protein) phosphatases II 16-152 1.9e-24 81.7 In-house 16-165 (174) alignment 
Range on Protein: 16-152
Range on HMM: 16-165/174.0
THKFILFDEPTEetipyFKDLMKKNSCINIVRCCEINYDA--------------SLFEGVKIHELCFKDGNVPPKDIIERWLEILKQAFIEngKQKTTVG
| ..|... |..     | ...|....  .|...| ...                  .|.... | . |..||. .|..........|. |  ... .| 
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvl

IHCIAGLGRTPLLVCIALIEDGM--KPLQAVEFVRSKR----KNAINSPQIKFLKEY
.|| ||.|||..||.. |.. |.  .. .|...||..|    .  ..  |..|| ..
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0049260 (Phosphotyrosine protein) phosphatases II 17-152 1.4e-27 91.7 In-house 9-145 (152) alignment 
Range on Protein: 17-152
Range on HMM: 9-145/152.0
HKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLF--EGVKIHELCFKDGNVPPKDIIERWLEILKQAFieNGKQKTTVGIHCIAGLGRTPLL
..|| .  |...|.. |....|.. .  ||...|  ... |.  .. ... | . |..||. ... ..| .. . .  . ... .| .|| ||.|||..|
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtl

VCIALIEDGMKPLQAVEFVRSKRKNAINSP-QIKFLKEY
|.. |.. |.....||..||.||..|. .| |..||.|.
vaaylmllgvsleeavalvrekRpgavpnpgqlrflyef
0046846 (Phosphotyrosine protein) phosphatases II 17-152 1.6e-25 85.3 In-house 23-168 (176) alignment 
Range on Protein: 17-152
Range on HMM: 23-168/176.0
HKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEI--------NYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAFIENgkqkTTVGIHCIA
...| ...|...|.. | ...|.. .  .|...|          .. ...|  |.... | . |..||. ......||....|  |.     .| .|| |
srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg....gpvlVHCsa

GLGRTPLLVCIALIED--GMKPLQAVEFVRSKRK-NAI-NSPQIKFLKEY
|.|||..||.. |.|   |.....|...||..|  .|. .  |..||.|.
GigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
0049772 (Phosphotyrosine protein) phosphatases II 17-154 1.8e-22 75.9 In-house 155-271 (314) alignment 
Range on Protein: 17-154
Range on HMM: 155-271/314.0
HkfilfDEPTEETIPYFKdlmkknscinivrccEINYDASLFEG--VKIHELCFKDGNVPPKDIIERWLEILKQAfiengKQKTTVGIHCIAGLGRTP--
.     .|||.......|               |. ||..|||.  .| . . . ||..|. ......||....|     .... | .|| || |||.  
g.....neptaadlellk...............eelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtf

LLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKA
..... ..  |. . .|.|.||.||   .|  .|..|..|  
vvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyef
0044763 (Phosphotyrosine protein) phosphatases II 18-153 9.6e-23 76.2 In-house 29-167 (178) alignment 
Range on Protein: 18-153
Range on HMM: 29-167/178.0
KFILFDEPTeetiPYFKDLMKKNSCINIVRCCEINY------DASLFEG--VKIHELCFKDGNVPP-KDIIERWLEILKQAFienGKQKTTVGIHCIAGL
 ..| . |.    . ...|.|.. .  ||...|  .      |.  .|.  .. . . . |..||.  .......|....|     ... .| .|| ||.
glylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal...dekggpvlVHCsaGv

GRTPLLVCIALI-EDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYK
||...||.. |. . |. . .|.|.||..|   .|  |...|.|. 
gRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefe
subfamily_PTEN_pd Subfamily PTEN 24-150 2e-12 42.5 In-house 45-173 (184) alignment 
Range on Protein: 24-150
Range on HMM: 45-173/184.0
EPTEETIPYFKDLMKKNSCINIVrCCEINYDASLFEGvKIHELCFKDGNVPPKDIIERWLEILKQaFIENGKqKTTVGIHCIAGLGRTPLLVCIALIEDG
  .|... ...   |..  |  . . | .||.. |.| ..... |.| | || ...|. .| ... ..|. | |  | .|| || ||| .|..  |.. .
nsledvvkflekkhkdhykiynl.rserkydskkfdg.rvavypfdDhnppplelleeivediek.wleedk.knvvvvHCkaGkGRtGvlivayllksl

MKPLQ--AVEFV---RSKRKNAINSP-QIKFLK
. . .  |.|.    |.| |...  | |.....
llekaeealelfaeaRtknkkgvtiPsqrRYve
0048179 (Phosphotyrosine protein) phosphatases II 27-153 2.5e-19 64.9 In-house 19-141 (144) alignment 
Range on Protein: 27-153
Range on HMM: 19-141/144.0
EETIPYFKDlMKKNSCINIvrCCEINYDASLFEGVKIHELCFKDGNVPPK-DIIERWLEILKQAFIengkQKTTVGIHCIAGLGRTPLLVCIALI-EDGM
 . ....|. .. .  ||.  . |  ..   .||.... | . | .||.  ......||....|      ..  | .|| ||.|||..||.. |. . |.
aldlellkk.lgittvinl..teeyepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklgl

KPLQAVEFVRSKRKNAI-NSPQIKFLKEYK
 . .|...|||.| .|. |  |..||.|| 
sleealalvrsrrpgavpnpgqlrfLleye
subfamily_CDC14_pd Subfamily CDC14 27-153 5.9e-19 63.1 In-house 202-320 (328) alignment 
Range on Protein: 27-153
Range on HMM: 202-320/328.0
EETIPYFkdlmKKNSCINIVRCCEINYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAfiengkqKTTVGIHCIAGLGRTPLLVCIALI-EDG
|. ..||    .||   ..||  . .|||. |.  |.. ..| | || .|.. |....|||...|       . .. .|| ||||||  |.   |. . .
eklleyf....rknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.......eGaiavhCkaGLGrtGtLiacylmkhyr

MKPLQAVEFVRSKRKNAINSPQIKFLKEYK
.   .|. ..|  |   . .|| |||.| .
ftaaeaiawlricrPGsvigpqqkfleekq
PTEN_1 32-157 1.2e-22 75.7 In-house 58-192 (196) alignment 
Range on Protein: 32-157
Range on HMM: 58-192/196.0
YFKDLMKKNSCINIVRCCEIN------YDASL--FEGVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKqKTTVGIHCIAGLGRTPLLVCIALIEDG
 ..| .|...   .|. .|.       || ..   .||. ... ..| ..|. . . .... .... ... . . .| .|| |||||. ..|.  |.. |
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykg

-MKPLQAVEFVRSKR-KNAINSPQIKFLKEYKASKK
 . . .|.|.||.|| ..|.|||. . |.|| |. .
kltadeAlelvrekRppgapnspsqerlleyfaell
0048076 (Phosphotyrosine protein) phosphatases II 38-152 7.3e-19 63.3 In-house 26-138 (145) alignment 
Range on Protein: 38-152
Range on HMM: 26-138/145.0
KKNSCINIVRCcEINYDASLFEGVKIHELCFKDGNVPPK-DIIERWLEILKQAFIENgkqkTTVGIHCIAGLGRTPLLVCIALIED-GMKPLQAVEFVRS
|..    ....   . .    .|.... | . | .||.  ......||....|  |.      | .|| ||.|||..||.. |.   |. . .|.|.|||
kdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrs

KRKNAI-NSPQIKFLKEY
.| .|. |  |..||.|.
qrpgavpnpgqlrflyef
PTPc_motif_SM00404 40-151 1.2e-11 39.7 In-house 29-133 (140) alignment 
Range on Protein: 40-151
Range on HMM: 29-133/140.0
NSCINIVRCCEINYDASLFEGVKIHeLCFkDGNVPPKDIIERWLEILKQAfienGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRk
  .||. . .....  | |. ..|  |   ... .  . ... |.....|     |....| .|| ||. |.  |..  |.. ....  .|.|||...| 
thvinvteevsltkensgfqilqip.ldd.nekdklskyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.

nAINSPQIKFLKE
  | ||...|...
.piispnlnfvrq
DSPc Dual specificity phosphatase, catalytic domain 43-151 7.3e-11 37.1 Pfam-A 23-129 (133) alignment 
Range on Protein: 43-151
Range on HMM: 23-129/133.0
INIVRCCEINydaSLFEGVKIHELCFKdGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRknAI
||. . .. |    ...  .|..|. .  .   .. |...|| ...   .  ... .| .|| ||. |.. |..  |.. ....  .|.|||...|   .
invtkevpnn...naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..sk

NSPQIKFLK---E
 ||...||.   |
ispnagflrqLle
DSPc Dual specificity phosphatase, catalytic domain 43-151 7.3e-11 37.1 In-house 23-129 (133) alignment 
Range on Protein: 43-151
Range on HMM: 23-129/133.0
INIVRCCEINydaSLFEGVKIHELCFKdGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRknAI
||. . .. |    ...  .|..|. .  .   .. |...|| ...   .  ... .| .|| ||. |.. |..  |.. ....  .|.|||...|   .
invtkevpnn...naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..sk

NSPQIKFLK---E
 ||...||.   |
ispnagflrqLle
subfamily_DSP1_pd Subfamily DSP1 43-152 1.3e-07 25.8 In-house 48-149 (163) alignment 
Range on Protein: 43-152
Range on HMM: 48-149/163.0
INIVRCCEINYDAsLFEGVKIHelcFKDGnvPPKDIIERWLEILKqaFIENGKQ-KTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRKna
.|. . ..  ..  |||  |..    .|   | .|| . . |...  ||.. |. .  | ||| ||. |   |. . |.. . ..  .| .||...|.  
lnvskeldnvfed.lfeYkklk...leDs..pkadislvfeevie..fidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs..

INSPQIKFLKEY
| || . | .. 
iisPnagFvlqL
0051429 (Phosphotyrosine protein) phosphatases II 45-151 4.1e-14 48.4 In-house 52-219 (272) alignment 
Range on Protein: 45-151
Range on HMM: 52-219/272.0
IVRCCEINYD--ASLFEGVKIHELCFKDGNVPPK----------------------------------------------------DIIERWLEILKQaf
. ...|....    . .|.... | . |  .|.                                                     . . ..||.| .  
LrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..

iengkqKTTVGIHCIAGLGRTPLLVCIALIEDGMK--------------PLQAVEFVRSKRKNAINSPQ-IKFLKE
      .  | .|| || .|| ..|.. |.  |.               ...||| .|..| .|. ... ..|| |
......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye
subfamily_DSP3_pd Subfamily DSP3 47-153 4.4e-07 23.7 In-house 47-154 (162) alignment 
Range on Protein: 47-153
Range on HMM: 47-154/162.0
RCCEINYDASLFEGVKIHELCFKDGNVPPKDIIERWLEIlkQAFIENG--KQKTTVGIHCIAGLGRTPLLVCI-ALIEDGMKPLQAVEFVRSKRKNAINS
|  ... .|. .....|. | ..  .||  |. . . .    .||..   .... | .|| .|. | . ||    .|   |.  .|.. ||.||.   |.
rfskvdtgaefykdleikylGlevdDvpefdlskyFeta..akfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPne

PQIKFLKEYK
  .| |.|..
GFlkqLaeld
0048567 (Phosphotyrosine protein) phosphatases II 48-150 2.3e-10 35.0 In-house 23-131 (157) alignment 
Range on Protein: 48-150
Range on HMM: 23-131/157.0
CCEINYDASLF---EGVKIHELCFKDGnVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGL---GRTPLLVCI-ALIEDGMKPLQAVEFVRSKRKNA
  . .|.|  |   .|.  ....|..|  .. .|. |.  .|.. .    ... .. .|| |||   ||| .|..  ...  |. | .|....|  | . 
lpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs

INSPQIKFLK
.  ..  .| 
vpfrdasyll
subfamily_RNGTT_pd Subfamily RNGTT 54-143 2.8e-08 27.7 In-house 69-160 (189) alignment 
Range on Protein: 54-143
Range on HMM: 69-160/189.0
DASLF--EGVKIHELCFK-DGNVPPKDIIERWLEILKQaFIEnGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKP-LQAVEFVRSKRKNAINS
|.. .  ||.| ..|  .  |. | .. .... ..... |..  . ....|.||  |  ||  |..  |.|       .||.  .. |.  |  
dkeelekegikyvklqcagkgeaPeaeqvkefiklvee.ffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyk
subfamily_PTPDC1_pd Subfamily PTPDC1 59-154 2.3e-14 48.3 In-house 81-173 (182) alignment 
Range on Protein: 59-154
Range on HMM: 81-173/182.0
EGVKIHELCFKDGNVPPkdiIERWLEILKqaFIENGKQKTTVGIHCIAGLGRTPLLVCIALI-EDGMKPLQAVEFVRSKRKNAINS-PQIKFLKEYKA
.|. .... .|| .|..   .|| |.| |   ..   |.  |..|| |||||| .|..  |.  . ... .|...||||| ..|..  |....||...
qgiyvynfgwkDygvas...leriLdivk..vvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefal
subfamily_PTPMT1_pd Subfamily PTPMT1 59-155 1.3e-09 32.8 In-house 72-167 (171) alignment 
Range on Protein: 59-155
Range on HMM: 72-167/171.0
EGVKIHELCFKDGN-VPPKDIIERWLEILKQAFiengKQKTTVGIHCIAGLGRTPLLVCIAL-IEDGMKPLQAVEFVRSKRKN-AINSPQIKFLKEYKAS
.||.. .|  .|    |  . .|. .|....      ... .| .|| || ||.  ||   |  .. ..| .|......|||   ... | | |.||. .
lgveqlqlatvDfteapdleklekgvefiekva....skgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_DSP23_pd Subfamily DSP23 59-147 6.7e-09 30.6 In-house 50-136 (148) alignment 
Range on Protein: 59-147
Range on HMM: 50-136/148.0
EGVKIHELCFKDGNVPPKDIIERWLEILKQAfienGKQKTTVGIHCIAGLGRTPLLV-CIALIEDGMKPLQAVEFVRSKRKNAINS-PQIK
 .. ...|  .|   |  . ..........|     ... .|..||. | |||  .. |  . | ..   .|.  || .|  ....  | |
pnltlvrlriddyhppaleqvvefvrvveea....eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqek
subfamily_DSP11_pd Subfamily DSP11 60-143 3.5e-11 37.3 In-house 79-163 (178) alignment 
Range on Protein: 60-143
Range on HMM: 79-163/178.0
GVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRKNAINS
||| . |     .|| ....... | .|.   .| .... .|.||  |. ||  |.|  ||. .|..| .|.|   . |  ... 
gvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler
subfamily_CDKN3_pd Subfamily CDKN3 60-156 3.1e-09 30.7 In-house 99-195 (202) alignment 
Range on Protein: 60-156
Range on HMM: 99-195/202.0
GVKIHELCFKDGNVPPKDIIERWLEILKQAFiengKQKTTVGIHCIAGLGRTPLLV-CIAL-IEDGMKPLQAVEFVRSKR-KNAINS-PQIKFLKEYKAS
|. .|   . || ||      . || |. ..    |. .   .||  ||||. |.. |. | ..| ..| .|.. .|  .  .||..  |  .|.|..  
glivhhypiadglvpdiasclkileelrinl....kayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdk

K
.
l
Y_phosphatase Protein-tyrosine phosphatase 68-145 7.3e-09 30.8 Pfam-A 143-225 (235) alignment 
Range on Protein: 68-145
Range on HMM: 143-225/235.0
FKDGNVPPKdiIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKP------LQAVEFVRSKRKNAINSP-Q
 .| .|| .   .  |.....   .. .... | .||.|| |||  .|.. .. . ..       ||.|. .|..| ....|  |
Wpdhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq
Y_phosphatase Protein-tyrosine phosphatase 68-145 7.3e-09 30.8 In-house 143-225 (235) alignment 
Range on Protein: 68-145
Range on HMM: 143-225/235.0
FKDGNVPPKdiIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKP------LQAVEFVRSKRKNAINSP-Q
 .| .|| .   .  |.....   .. .... | .||.|| |||  .|.. .. . ..       ||.|. .|..| ....|  |
Wpdhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq
PTPc_DSPc_SM00012 69-144 3.7e-09 32.1 In-house 11-93 (105) alignment 
Range on Protein: 69-144
Range on HMM: 11-93/105.0
KDGNVPPK-DIIERWLEILKQAFIENGKqKTTVGIHCIAGLGRTPLLVCIALIEDG-------MKPLQAVEFVRSKRKNAINSP
.| .|| . | | ..|. .|.   .... .. | .|| || |||  .|..... .        .. .| |. .|..| ..... 
pdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_LRR-DSP_pd Subfamily LRR-DSP 74-151 3.3e-08 26.9 In-house 176-253 (263) alignment 
Range on Protein: 74-151
Range on HMM: 176-253/263.0
PPKDIIERWLEIlkQAFIENGKQKTTVGIHCIAGLGRTPLLVC-IALIEDGMKPLQAVEFVRSKRKNAInsPQIKF---LKE
.  ||   . |.   ||||.|..|  | .|| ||. |.  ||    .  . .|  .|...| .|| .    | . |   || 
deadisqhfeet..nafieeGrkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriq..PnpGfkdqlkk
subfamily_DSP19_pd Subfamily DSP19 75-156 1.5e-08 29.1 In-house 68-150 (152) alignment 
Range on Protein: 75-156
Range on HMM: 68-150/152.0
PKDIIERWLEIlkQAFIENGKQK-TTVGIHCIAGLGRTPLLVCIALIEDGMKPL-QAVEFVRSKRKNA-INSPQIKFLKEYKASK
 .|... . |.  . |||....|  .| .|| ||  |.. .|   |...  . | .|.| ||..|...  |.  || ||||.|..
etdllsylkea..ldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 76-161 1.3e-07 26.1 In-house 62-145 (155) alignment 
Range on Protein: 76-161
Range on HMM: 62-145/155.0
KDIIERwLEILkQAFIENGK-QKTTVGIHCIAGLGRTPLlVCIALI--EDGMKPLQAVEFVRSKRKNAinSPQIKFLKEYKASKKAGCK
.||..  |.    .|||..  .. .| .|| ||. |    ..|| .  .....  .|...|..|....  .|   ||.  |  .| |||
ediLsh.ldea.vdFieealeeegavlvHCqagvSRSvt.iviAYlmkkeklslekAlklvkekkpei..epNegFleQLklfekmgck
subfamily_DSP10_pd Subfamily DSP10 88-151 2.2e-07 24.9 In-house 82-145 (159) alignment 
Range on Protein: 88-151
Range on HMM: 82-145/159.0
QAFIENGKQK-TTVGIHCIAGLGRTPLLVCIAL-IEDGMKPLQAVEFVRSKRknAINSPQIKFLKE
 .|||. ..| ..| .|| ||. |   .|   |  . ...  .| .||..||  .| || . |. .
lefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekr..piisPnLnfmGq
subfamily_DSP6_pd Subfamily DSP6 89-151 3.5e-06 20.6 In-house 84-146 (158) alignment 
Range on Protein: 89-151
Range on HMM: 84-146/158.0
AFIENGKQK-TTVGIHCIAGLGRTPLLVCIALIEDGMKPL-QAVEFVRSKRKNAinSPQIKFLKE
.||.....| ..| .||.||. |.  ..   |..  .  | .| ..|.... |   ||  .|.. 
efidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksni..sPnfnfmgq
MOZART1 Mitotic-spindle organizing gamma-tubulin ring associated 107-128 1.1e-06 15.5 Pfam-A 18-39 (48) alignment 
Range on Protein: 107-128
Range on HMM: 18-39/48.0
GLGRTPLLVCIALIEDGMKPLQ
|| |. | .||.|.| |..| .
gLdreaLsicieLleaGVnPea