Gene plip in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP021_AA protein Get Run
DdisP021_AA_75-220 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0041856 (Phosphotyrosine protein) phosphatases II 72-211 8.2e-28 92.6 In-house 17-163 (182) alignment 
Range on Protein: 72-211
Range on HMM: 17-163/182.0
GlrgpFISQLDDNVYLGAMPMG-------------SDVTLLFYKYKINSIVNLCdEYQGPTQHYTQYGMQQLYVPVVDHFEPDveiIEKSIQFILKQIEL
     ....  .|.|||..|                |   ......|..||||. |.. . ......|.| ||.|. ||  ||   ... ..|| . .| 
r....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd...ldelldfieevlee

GNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRK--IVRKQLYKQK
|..|..||.||.||.|....... ....|||| | | . ..|   ... . |   
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyffl
0044763 (Phosphotyrosine protein) phosphatases II 73-220 6.2e-30 99.5 In-house 18-170 (178) alignment 
Range on Protein: 73-220
Range on HMM: 18-170/178.0
LRGPFISQLDDNVYLGAMPMgSDVTLLFYKYKINSIVNLCDEYQG-----PTQHYTQYGMQQLYVPVVDHFEPD-VEIIEKSIQFILKQI-ELGNRVYIH
 ... .|. ....|||. |. .|   |.....|..||||..|. .     . ......|.| |..|..|| .||  |.... ..|| . . | |..|..|
sdyinaseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKiVRKQLYKQKNVNQYYSSY
|.||.||||....... .....||| | . . |.|  .      .. . .... .
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_PTPMT1_pd Subfamily PTPMT1 75-221 9.6e-52 169.9 In-house 17-169 (171) alignment 
Range on Protein: 75-221
Range on HMM: 17-169/171.0
GPFISQLDDNVYLGAMPMGSDVTLLFYKYKINSIVNLCDEYQ-----GPTQHYTQYGMQQLYVPVVDHF-EPDVEIIEKSIQFILKQIELGNRVYIHCKA
 ......||.|.|||.|. |... |..|......|.|..||.      .|......|..||....||.. .||.| .||...|| |....|.|||.||||
rnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCka

GRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYSSYC
|||||.....|........|.|.|.|.| .||||.|.. ...|....|.....
GrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
0046846 (Phosphotyrosine protein) phosphatases II 75-202 3.6e-29 97.1 In-house 9-153 (176) alignment 
Range on Protein: 75-202
Range on HMM: 9-153/176.0
GPFISQLDDNVYLGAMP----------MGSDVTlLFYKYKINSIVNLCDEY-------QGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIE
.........|..||..|          . ...  ......|. .|||..|.           . ....|.| |..|..||  || |.... ..|| ....
dldldyinanlilgsrpiatqgplprtladfle.mlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealk

LGNRVYIHCKAGRGRSGAIAICWIAYS-RRVSLEVAQKILLEKRKI
 |..|..||.||.||.|....... .. . .|.| | . . |.|  
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl
0048179 (Phosphotyrosine protein) phosphatases II 76-204 6.6e-28 92.6 In-house 2-128 (144) alignment 
Range on Protein: 76-204
Range on HMM: 2-128/144.0
PFISQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEyqGPTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSG
...|. ....||| .|. .|. ||  |..|. ..||..|   . ......|.| |..|. ||  ||  |.... ..|| . .| |..|..||.||.||.|
snpseilpglylgslptaldlell.kklgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtg

AIAICWIAYSRRVSLEVAQKILLEKRKIVR
....... . ...||| | . . ..| .. 
tlvaaylmkklglsleealalvrsrrpgav
0045098 (Phosphotyrosine protein) phosphatases II 76-204 4e-20 67.8 In-house 20-255 (278) alignment 
Range on Protein: 76-204
Range on HMM: 20-255/278.0
PFISQLDDNVYLGAMPM----------------------------------------GSDVTLLFYKYKINSIVNLCDEYQGP-----------------
...|.  ...||| ...                                         .|   ......|..||.|......                  
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

------------------------T----QHYTQYGMQQLYV-PVVDHFEPDVE---IIEKSIQFILKQIE--------------LGNRVYIHCKAGRGR
                        .    ......|...|.  |. ||  |. .    . . ..||.. ..               |..|..||.|| ||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SGAIAICWIAYSR---RVSLEVAQKILLEKRKI-VR
.|....... ...   .|.|. | | | ..| . . 
tGtlvaaylmlelleggvdlleavkelrsqRpglav
subfamily_DSP23_pd Subfamily DSP23 76-194 2.7e-08 28.6 In-house 3-119 (148) alignment 
Range on Protein: 76-194
Range on HMM: 3-119/148.0
PFISQLDDNVYLGAMPMGSDVTLLFYKYKINSIVNLCDEYQGPTQHYTQYGMQQLYVPvvDHFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGA
||.| .  ..   |.|   |    .    .  .| | .| . ...   .  ...| ..  |.  | .| ... .. . .  | .. | .||  ||||.|.
pffswvssrlaalalprlpdqyrylldlgvrylvslteegrphveatpnltlvrlrid..dyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgt

IAICWIAYSRRVSLEVAQK
.  |..   |...   |  
mlacylvkerklaaaeaia
0048076 (Phosphotyrosine protein) phosphatases II 77-207 2.1e-26 87.7 In-house 3-129 (145) alignment 
Range on Protein: 77-207
Range on HMM: 3-129/145.0
FISQLDDNVYLGAMPMGSDvTLLFYKYKINSIVNLCDEYQGPTqhytQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGA
..|. ....||| .|. .|   |. ...|  ..||..| ....    ..|.| ||.|. || .||  |.... ..|| . .. |..|..||.||.||.|.
wpseilpglylgslptald.lellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgt

IAICWIAYSRRVSLEVAQKILLEKRKIVRKQL
...... ....|||| | . . ..| ..    
lvaaylmlllgvsleealelvrsqrpgavpnp
PTEN_1 78-219 1.5e-25 85.2 In-house 41-190 (196) alignment 
Range on Protein: 78-219
Range on HMM: 41-190/196.0
ISQLDDNVYLGAMPMGSDVTLLFYKYKINSIVNLCDEYQ-----GPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIEL---GNRVYIHCKAG
....|...|.| ..  ..    ... .| ..|||..|.      .. ... . |...| .|. ||  |. . . . .  .  .. .   || |..|||||
lqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaG

RGRSGAIAICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYSS
.|||| .....  |... . . | ... |||  ....  .|. . .|...
lgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
subfamily_DSP1_pd Subfamily DSP1 78-218 1.4e-18 61.5 In-house 19-154 (163) alignment 
Range on Protein: 78-218
Range on HMM: 19-154/163.0
IsQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYQGPTQHYTQYGMqqlyVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAI
  .. | .|||.    |.. .|  . .|  |.|.  | .   ... .|      ... |. . |.  ..|. |.|| . .. . .|.|||.||  || ..
e.kildfLylGsetvasnleiL.kslgitailnvskeldnvfedlfeYkk....lkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

AICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYS
 . ..  ..||||| | .   ..|.|..  .  .... .| .
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
subfamily_DSP19_pd Subfamily DSP19 78-204 4.5e-14 47.1 In-house 12-134 (152) alignment 
Range on Protein: 78-204
Range on HMM: 12-134/152.0
ISQLDDNVYLGAMPMGSDVTLLFyKYKINSIVNLCDEYqgpTQHYTQyGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAI
.... ...|||..   .| . |  . ||  |.|.  .     .....  .. | ....|. | |. ........|| .  .  ..|..||.||. || ..
vgeveprlylgsqdvaadkeilk.ekkitHilnvatgv...pnvfpk.dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

AICWIAYSRRVSLEVAQKILLEKRKIVR
.| ..  ....||| | . . |.|. ..
viaylmkkeelsleealelvrearpcik
subfamily_DSP14_pd Subfamily DSP14 78-204 6e-12 39.8 In-house 7-128 (157) alignment 
Range on Protein: 78-204
Range on HMM: 7-128/157.0
ISQLDDNVYLGAMpmGSDVTLLFYKYKINSIVNLCDeyQGPTQHYTqyGMQQLYVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAI
.||. .. .|...  ..    |. |.||. |.|.    . |....   ..... ||| |. | ..    .. .. | .  . | .. .||.||. || ..
lsqitpsLflsgv..aalskellkkkkitliinvtv..elpntklk..diervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAsl

AICWIAYSRRVSLEVAQKILLEKRKIVR
.. ..   ...||. | |.. ..| |.|
claylmkyeklsLreayklvksaRpiir
0051082 (Phosphotyrosine protein) phosphatases II 79-201 1.7e-24 81.5 In-house 9-133 (151) alignment 
Range on Protein: 79-201
Range on HMM: 9-133/151.0
SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCD--EYQGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIEL--GNRVYIHCKAGRGRSG
|......|....|.  .. || ....|..||||..  |..  .. ....|.. |..|..|. .|..... .... .|....   .. |..||.||.||.|
syvtgglyrsggpladflell.kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

AIAICWIAYsRRVSLEVAQKILLEKRK
....... . ..|||| | . ...|| 
tlvalylml.lgvsleealeeyrlkrp
PTPc_motif_SM00404 79-207 7.9e-17 56.4 In-house 3-128 (140) alignment 
Range on Protein: 79-207
Range on HMM: 3-128/140.0
SQLDDNVYLGAMPMGSdVTLLFYKYKINSIVNLCDEYQGPtqhYTQYGMQQLYVPVVD-HFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA
|.  ...|||  .  .    |  |..|  ..|. .| . .   . . |.| | .|. | . .. .. ..| ..|| . .. | .|..||.||  ||....
srilphlylgskskaq.npallkklgithvinvteevslt...kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli

ICWIAYSRRVSLEVAQKILLEKRKIVRKQL
|... ..| .||. | ... |.|.|....|
iaYlmryrqlslaeayefvkerRpiispnl
subfamily_DSP12_pd Subfamily DSP12 79-205 9.5e-16 52.6 In-house 3-128 (155) alignment 
Range on Protein: 79-205
Range on HMM: 3-128/155.0
SQLDDNVYLGAMPMGSDVtLLFYKYKINSIVNLCDEYQgPTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA
|......||| ...  .   |  ..||.... .  |   |. . ..  .........|. | |. . ... ..|| . .| .. |..||.||  || .| 
srilpglylggleavqee.ellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiv

ICWIAYSRRVSLEVAQKILLEKRKIVRK
| .. .. ..||| | |.. ||.. .. 
iAYlmkkeklslekAlklvkekkpeiep
subfamily_DSP8_pd Subfamily DSP8 79-219 4.4e-15 49.6 In-house 16-153 (159) alignment 
Range on Protein: 79-219
Range on HMM: 16-153/159.0
SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLcdEYQGPTQHYTQYGMqQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA
 .. .|.|||.     . .||  |. |. ..|.  . . |...  .     | ||| |... .. ....||..|| |  .   || .|. ||. || ..|
trilknlylGsqkdvlseell.sklgisyvlna..snscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

ICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQYYSS
|..|    ..||. | . . |||. . ..|  .. . .|. .
iayimktlemsldeayrfvkekrptispnlnflgqLleyeke
subfamily_Slingshot_pd Subfamily Slingshot 79-211 1.2e-09 31.7 In-house 20-148 (169) alignment 
Range on Protein: 79-211
Range on HMM: 20-148/169.0
SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYQGPTQHYtqygMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA
|.. | ||||.    |..  |  . ... |.|.  | .   ..     .. | . | |. | |. .  ... .|| |  . | .| .||| |  || .. 
skifdhvylGsewnasnleel.kengveyilnvtkeidnffpek....feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastv

ICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQK
| .   . ..||| | . . |.|....      |
iayamkeyglsleealeyvkerrsvikPnkgflk
subfamily_DSP15_pd Subfamily DSP15 79-216 1.5e-09 32.1 In-house 3-135 (151) alignment 
Range on Protein: 79-216
Range on HMM: 3-135/151.0
SQLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDeyqgPTQHYTQYgMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIA
|..  ..||| .   .| .||  . .|  |... |     .... .  .. ..... |  . .. .....|..|| |    .. |..|| ||  ||  ..
skvlpglylgnfrdskdeelL.keknithilsvhd....nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlv

ICWIAYSRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQY
. ..     .. . | ... ..| .    .  .. ...|
vaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkey
Y_phosphatase2 Tyrosine phosphatase family 79-179 5.1e-06 18.4 Pfam-A 8-111 (165) alignment 
Range on Protein: 79-179
Range on HMM: 8-111/165.0
SQLDDNVYLGAMPMGSDVTLLFYkYKINSIVNLCDE-Y-QGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQI-E-LGNRVYIHCKAGRGRSG
|. . ..| ...|. |    |    |. .|. |..| . | ..|  ..  .. . . . .  |..|||...... .|| . .     |..||| |. | |
saveselyrssyprasnfsflks.LkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrGkhrtg

AIAIC
 .  |
lvigc
0037934 (Phosphotyrosine protein) phosphatases II 80-203 2.5e-23 78.3 In-house 41-224 (243) alignment 
Range on Protein: 80-203
Range on HMM: 41-224/243.0
QLDDNVYLGAMPMGSD-------VTLLFYKYKINSIVNLCDEY----------------------------------------QGP-TQHYTQYGMQQLY
.  ...... .|. .           ......|..||.|....                                        . . ....|..... .|
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

VPVVDHFEPD-VEIIEKSIQFILKQIEL---------GNRVYIHCKAGRGRSGAIAICWIAYSR-RVSLEVAQKILLEKRKI-V
.|. ||  || .|.. . .... . ||          |..|..||.||.||.|....... ... .|.|| | | | |.|   .
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgka
subfamily_DSP6_pd Subfamily DSP6 80-201 2e-12 40.9 In-house 16-135 (158) alignment 
Range on Protein: 80-201
Range on HMM: 16-135/158.0
QLDDNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYqgPTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAI
.. ...|||.    |.. .|  |.||. ..|.  .   | ..  .  .. | .|. ||.. .. . . ..|.|| .  .  . | .|| ||  || ....
eilpllylGsakdasnlevl.kklkikyvlnvtsnl..pnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

CWIAYSRRVSLEVAQKILLEKRK
...  .. .||. | ... ... 
aylmkklalslndaydlvkkrks
0036282 (Phosphotyrosine protein) phosphatases II 81-200 7.8e-26 86.2 In-house 15-146 (174) alignment 
Range on Protein: 81-200
Range on HMM: 15-146/174.0
LDDNVYLGAMPMGsdVTLLFYKYKINSIVNLCDEYQGP-----------TQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIEL--GNRVYIHCK
  .....|. |.      ......|...|.|..|..              ......|.| ||.|..|| .||..|... ..|. . ..   |. |..||.
itprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCs

AGRGRSGAIAICWIAYSRRV-SLEVAQKILLEKR
||.||.|....... . .   ||. | ... |.|
aGvgRtGtlvaaylmlrglleslvdaldlvrelR
0042113 (Phosphotyrosine protein) phosphatases II 81-203 1.2e-23 79.3 In-house 50-225 (245) alignment 
Range on Protein: 81-203
Range on HMM: 50-225/245.0
LDDNVYLGAMPMGSDVT---LLFYKYKINSIVNLCDEYQGP------------------------------------------TQHYTQYGMQQLYVPVV
  ....... |. ..|     ......|..||.|..|                                                .... ... .|.|. 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DHFEPD-VEIIEKSIQFILKQIE--LGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRKIV
|| .|| .|.... ..|..|...   ...|..||.||.||.|........     . ..|||| | | | ..|  .
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpga
subfamily_MKPLT_pd Subfamily MKPLT 81-205 9.4e-11 35.5 In-house 25-145 (164) alignment 
Range on Protein: 81-205
Range on HMM: 25-145/164.0
LDDNVYLGAMPMGSDVTLlFYKYKINSIVNLCDEYQGPTQHYTQYGMQQLYVPVVDHFEPdveIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICW
|.|..|||      . ..   . ||. |||.  | .    .  .|   ..   . ... .    .|.  .|. . |. | ||..||  |. || .... .
ledtlylGnakhatnekv.lkdlkithivnvsqekkdafpksveYlqvkvedesdeqlss...fleraakfladaidsGGrvlvhcvqGksrsssvtvaf

IAYSRRVSLEVAQKILLEKRKIVRK
.  |..  |. | . | |.| ||. 
Likskgwtlkeayeylkerrsivap
subfamily_MKPLV_pd Subfamily MKPLV 81-205 9.4e-11 35.5 In-house 25-145 (164) alignment 
Range on Protein: 81-205
Range on HMM: 25-145/164.0
LDDNVYLGAMPMGSDVTLlFYKYKINSIVNLCDEYQGPTQHYTQYGMQQLYVPVVDHFEPdveIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICW
|.|..|||      . ..   . ||. |||.  | .    .  .|   ..   . ... .    .|.  .|. . |. | ||..||  |. || .... .
ledtlylGnakhatnekv.lkdlkithivnvsqekkdafpksveYlqvkvedesdeqlss...fleraakfladaidsGGrvlvhcvqGksrsssvtvaf

IAYSRRVSLEVAQKILLEKRKIVRK
.  |..  |. | . | |.| ||. 
Likskgwtlkeayeylkerrsivap
0039614 (Phosphotyrosine protein) phosphatases II 82-203 5.7e-19 64.1 In-house 100-271 (297) alignment 
Range on Protein: 82-203
Range on HMM: 100-271/297.0
DDNVYLGAMPMGSDV---TLLFYKYKINSIVNLCDEYQGPTqHYTQY---------------------------------------GMQQLYVPVVDHFE
......   |. . |     .........||.|...      .. ||                                        .. .|..  ||  
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgv

P-DVEIIEKSIQFILKQIE---LGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRKIV
| ..|.. . .... ....    |..|..||.|| ||.|........     . ..|... | | | |.|  .
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpga
0051429 (Phosphotyrosine protein) phosphatases II 82-203 5.3e-18 61.1 In-house 21-207 (272) alignment 
Range on Protein: 82-203
Range on HMM: 21-207/272.0
DDNVYLGAMP---MGSDVTLLfYKYKINSIVNLCDEYQGPTQ--HYTQYGMQQLYVPVVDHFEPDVEIIE------------------------------
.. .|....|      |.  | ....|..||.|..|.  . .  ..   |.. |..|..|. .|.....                               
pgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

------------------KSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYsRRVS--------------LEVAQKILLEKRKIV
                  ...  .|...  |..|..||.||..|.| .. ... . ..||              || | . | ..|  .
revmhlhytdwpdhgvpqeallellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpga
subfamily_STYXL1_pd Subfamily STYXL1 82-202 9.3e-09 28.7 In-house 16-135 (157) alignment 
Range on Protein: 82-202
Range on HMM: 16-135/157.0
DDNVYLGAMPMGSDVtLLFYKYKINSIVNLCDEYQGpTQHYTQYGMQQLYVPVVDHFEPDV-EIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICW
 ...||| .    .   . .  |. . ||.  . .   .. ..   . | ..| |. | |. | ... .||| |  . |. | .  . |  || |..|..
PgklylGnykqaqnp.aikkdlkvkahvnvsmdadk.liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

IAYSRRVSLEVAQKILLEKRKI
. ||....|..| | | . .. 
lmyskkitlkkaykylkkCken
0043336 (Phosphotyrosine protein) phosphatases II 83-201 3.1e-18 61.7 In-house 88-257 (278) alignment 
Range on Protein: 83-201
Range on HMM: 88-257/278.0
DNVYLGAMPMGSDV---TLLFYKYKINSIVNLCDEYQGP-----------------------------------------TQHYTQYGMQQLYVPVVDHF
.....   |. . |     .........||.|...                                               ........  |... || 
rkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhg

EP-DVEIIEKSIQFILKQIE-LGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRK
 | ..... . ........|  .. |..||.|| ||.|........     . ..|.|| | | | |.| 
vpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRp
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 83-207 1.1e-15 51.4 In-house 13-134 (148) alignment 
Range on Protein: 83-207
Range on HMM: 13-134/148.0
DNVYLGAMPMGSDVTLLfYKYKINSIVNLCDEYQGPtqhYTQYGMQQLYVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWI
  ..||. .. .|.  |  .  .  |||   | . .   . | |.. | |.. |. . |.  | |. |.|. |. . |.|| .|.. |. || |.|. |.
afLFlGskksaadleal.kalgvtrivnatkerdna...ldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwl

AYSRRVSLEVAQKILLEKRKIVRKQL
   .||||. |  .  .||. |...|
idfkrvslkealalvkskrryvdpnl
subfamily_DSP3_pd Subfamily DSP3 83-204 6.6e-11 36.1 In-house 16-142 (162) alignment 
Range on Protein: 83-204
Range on HMM: 16-142/162.0
DNVYLGAMPMGSDVTLLfYKYKINSIVNLCDE-Y---QGPTQHYTQYGMQQLYVPVVDHFEPDVEI-IEKSIQFILKQIEL-GNRVYIHCKAGRGRSGAI
...|.|   . .| . |  |  |  ..| ..  .   .  ...|.. ... | ..| | .| |..   |.. .|| . ..    .|..||..|  || ..
pklyvgdeavakdkskL.kklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatl

AICWIAYSRRVSLEVAQKILLEKRKIVR
.. ..  .|...|  | .   .||.|. 
vlayLmirrkmtlveairtvrkkReilP
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 84-204 3.1e-10 33.6 In-house 9-136 (154) alignment 
Range on Protein: 84-204
Range on HMM: 9-136/154.0
NVYLGAMPMGSDVtLLFYKYKINSIVNL-CDEYQGPTQH--YTQYGMQQLYVPVVDHFEPDVEII---EKSIQFILKQI--ELGNRVYIHCKAGRGRSGA
..|....    .  |.. ...|.||.|         |..    . |.   |. .  . ... .||   .|. .|| ..|     |.| .|...|  || |
flyissfdaalnk.ldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

IAICWIAYSRRVSLEVAQKILLEKRKIVR
..| ..  ....||  | ..| . | |..
llisylmdklkislslalellkdsryiik
0049772 (Phosphotyrosine protein) phosphatases II 85-220 3.8e-24 81.4 In-house 155-273 (314) alignment 
Range on Protein: 85-220
Range on HMM: 155-273/314.0
VylgAMPMGSDVTLLFykykinsivnlcdEYQGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQiELGNRVYIHCKAGRGRSG-AIAICWIAY
    ..|  .|. ||              | . . ......|.. |..|| |. .|. |.... ..||..  . |..|..|||||.||.| ....... .
g...neptaadlellk.............eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk

SRRVSLEVAQKILLEKRKiVRKQLYKQKNVNQYYSSY
 ..|||| | . . .||  .. .    .. .||.  .
llgvsleealedvrlkRp.inpnpgfieqleqyefil
DSPc Dual specificity phosphatase, catalytic domain 85-216 1.9e-17 58.4 Pfam-A 1-130 (133) alignment 
Range on Protein: 85-216
Range on HMM: 1-130/133.0
VYLGAMPMGSdvTLLFYKYKINSIVNLCDEYQGPtQHYTQYGMQQLYVPVVD-HFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAY
.|||. .  |    |  |..|. ..|. .| . . . ...   ..| .|| | . .  .. .|....|| | .. |..|..||.||  ||....|... .
lylgskstas..lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmk

SRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQY
....||. | ... |.|......   .. . .|
tknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 85-216 1.9e-17 58.4 In-house 1-130 (133) alignment 
Range on Protein: 85-216
Range on HMM: 1-130/133.0
VYLGAMPMGSdvTLLFYKYKINSIVNLCDEYQGPtQHYTQYGMQQLYVPVVD-HFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAY
.|||. .  |    |  |..|. ..|. .| . . . ...   ..| .|| | . .  .. .|....|| | .. |..|..||.||  ||....|... .
lylgskstas..lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmk

SRRVSLEVAQKILLEKRKIVRKQLYKQKNVNQY
....||. | ... |.|......   .. . .|
tknlslneAyefvkerrskispnagflrqLley
subfamily_DSP10_pd Subfamily DSP10 85-205 1.1e-13 45.3 In-house 21-138 (159) alignment 
Range on Protein: 85-205
Range on HMM: 21-138/159.0
VYLGAMPMGSDVtLLFYKYKINSIVNLCDeyQGPTQHYTqYGMQQLYVPVVDHFEPDVE-IIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAY
..||.    .|   .. ...|. ..|.    . |....   ...   .|| |  . ...   |....|| .  . |.|| .||.||  || ...| .. .
LflGsekdaadl.daldrlnitavlnvtt..svPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmk

SRRVSLEVAQKILLEKRKIVRK
 ...||. | |   ||| |.  
hlnlslndaykfvkekrpiisP
subfamily_CDC14_pd Subfamily CDC14 90-187 7.5e-10 33.2 In-house 200-291 (328) alignment 
Range on Protein: 90-187
Range on HMM: 200-291/328.0
MPmgSDVTLLFYKYKINSIVNLCDEYQgPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQfILKQIelGNRVYIHCKAGRGRSGAIAICWIAYSRRV
 |    .   | |......| |  .     ...|. |..   .  .|   |. .|..| .. |....     . .||||| || |..  |.. .  |.
aP..eklleyfrknnvttvvrLnkklY.dakkftdaGfdhkDlffiDGstPsdaivkkfle.iaeka..eGaiavhCkaGLGrtGtLiacylmkhyrf
0043147 (Phosphotyrosine protein) phosphatases II 95-204 2.3e-25 84.7 In-house 35-144 (172) alignment 
Range on Protein: 95-204
Range on HMM: 35-144/172.0
DVTLLFYKYKINSIVNLCdEYQGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILK--QIELGNRVYIHCKAGRGRSGAIAICWIAYsRRVSLEVA
|.  ......|. ||||. | . ........|.| ||.|. ||  |. |.... ..|| .  ... |..|..||.|| ||.|....... . ...||| |
dfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleea

QKILLEKRKIVR
 . . ||| .. 
valvrekRpgav
0049260 (Phosphotyrosine protein) phosphatases II 95-204 2.3e-21 71.5 In-house 24-133 (152) alignment 
Range on Protein: 95-204
Range on HMM: 24-133/152.0
DVTLLFYKYKINSIVNLCDEYQGPTQHYTQYGmQQLYVPVVDHFEPDVEIIEKSIQFILKQ--IELGNRVYIHCKAGRGRSGAIAICWIAYsRRVSLEVA
|.  ......|. ||.|....  .     ||  | |..|. ||  || ... . .  ....  .. |..|..||.|| ||.|....... . ..|||| |
dfwrmlkelgittivmltellelgklkceqyi.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleea

QKILLEKRKIVR
 . . |||... 
valvrekRpgav
0040439 (Phosphotyrosine protein) phosphatases II 97-203 1.4e-16 56.3 In-house 71-228 (249) alignment 
Range on Protein: 97-203
Range on HMM: 71-228/249.0
TLLFYKYKINSIVNLCDEYQ--------------------------------------------GPTQHYTQYGMQQLYVPvVDHFEPDVEIIEKSIQFI
  ......|..||.|... .                                            .  ...| ...| .  |  ..  |..|.. . |. .
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieav

LKQIE---LGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRKIV
.| .|    |..|..||.|| ||.|........     . ..|.|| | | | ..|  .
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpga
0045450 (Phosphotyrosine protein) phosphatases II 98-203 1.4e-16 56.6 In-house 125-286 (307) alignment 
Range on Protein: 98-203
Range on HMM: 125-286/307.0
LLFYKYKINSIVNLCDEYQGPTQHYT------------------------QYGMQQLYVPV--------------------VDHFEP-DVEIIEKSIQFI
 ........ ||.|...     . .                         . |.. ....|                     ||  | ..|.. . |. .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

LKQIE---LGNRVYIHCKAGRGRSGAIAICWIAYSRR--------VSLEVAQKILLEKRKIV
.| .|    |..|..||.|| ||.|............        |.|. | | | |.|  .
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpga
0040438 (Phosphotyrosine protein) phosphatases II 99-204 2.9e-15 51.8 In-house 105-259 (317) alignment 
Range on Protein: 99-204
Range on HMM: 105-259/317.0
LFYKYKINSIVNLCDEYQGP-----------------------TQHYTQYGMQQLYVPV-------------------VDHFEP-DVEIIEKSIQFILKQ
.........||.|... .                         .. ..  |.. . ..|                    ||  | . ... . .... ..
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

IEL-GNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRKIVR
.|  |. | .||.|| ||.|........     . ..|..| | | | |.|  . 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgav
0047943 (Phosphotyrosine protein) phosphatases II 99-202 3e-15 51.8 In-house 96-253 (273) alignment 
Range on Protein: 99-202
Range on HMM: 96-253/273.0
LFYKYKINSIVNLCDEYQGPT---------------------------------------------QHYTQYGMQQLYVPVVDHFEP-DVEIIEKSIQFI
........ || |.....                                                 ... . .. .| .  ||  | ..|.. . |...
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

LKQIE---LGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRKI
 |..|    .. |..||.|| ||.|........     . ..|... | | | ..|  
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg
0050432 (Phosphotyrosine protein) phosphatases II 99-201 5.4e-13 44.4 In-house 127-279 (308) alignment 
Range on Protein: 99-201
Range on HMM: 127-279/308.0
LFYKYKINSIVNLCDEYQGPTQHYTQ------------YG---------------------------------MQQLYVPVVDHFEPD-VEIIEKSIQFI
........ || |.....   . . |            ||                                 ..  |    ||  |. .||. . ....
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

LKQIeLGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKRK
 |..  |. ...||.|| ||.|........     . ..|... | | | |.| 
rksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
0046845 (Phosphotyrosine protein) phosphatases II 100-201 1.9e-12 42.6 In-house 97-254 (284) alignment 
Range on Protein: 100-201
Range on HMM: 97-254/284.0
FYKYKINSIVNLCDEYQGPT--------------------------------------------QHYTQYGMQQLYVPVVDHFEP-DVEIIEKSIQFILK
 ...... || |... .                                                 .. . ..  | .  ||  | ..|.. . .... .
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

QIEL---GNRVYIHCKAGRGRSGAIAICWIAYSR--------RVSLEVAQKILLEKRK
..|    |. . .||.|| ||.|...........        .|... | | | |.| 
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
0036941 (Phosphotyrosine protein) phosphatases II 101-206 4.3e-14 47.9 In-house 99-262 (297) alignment 
Range on Protein: 101-206
Range on HMM: 99-262/297.0
YKYKINSIVNLCDEYQGPTQHYTQYG--------------------------------M--------------QQLYVPVVDHFEPD-VEIIEKSIQFIL
.......||.|.....   . . ||                                 .              .  |    ||  |. .... . |....
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KQIE---LGNRVYIHCKAGRGRSGAIAICWIA--------YSRRVSLEVAQKILLEKRKIVRKQ
|...    |..|..||.|| ||||........        . ..|..  | | | |.|  .  .
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqt
0051299 (Phosphotyrosine protein) phosphatases II 101-200 2.6e-12 42.3 In-house 113-265 (288) alignment 
Range on Protein: 101-200
Range on HMM: 113-265/288.0
YKYKINSIVNLCDEYQGP----------------------------------------------TQHYTQYGMQQLYVPVVDHFEPD-VEIIEKSIQFIL
...... || |....                                                  ...... ..  |    ||  || .| . . .... 
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

KQIE-LGNRVYIHCKAGRGRSGAIAICWIA-----YSRRVSLEVAQKILLEKR
|...  |. |..||.|| ||.|........     . ..|... | | | |.|
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqR
subfamily_PRL_pd Subfamily PRL 101-206 7.4e-06 20.1 In-house 31-138 (151) alignment 
Range on Protein: 101-206
Range on HMM: 31-138/151.0
YKYKINSIVNLCDEyQGPTQHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIE--LGNRVYIHCKAGRGRSGAI-AICWIaySRRVSLEVAQKILL
 |......|  |.  .  |..  . |.. | ..  |   |  |..|. .. . .. .   .. | .|| || ||.  . |.. |     .. | | ... 
kkeevktvvrvcep.tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali..eaGmkyedavefir

EKRK--IVRKQ
|||.  | .||
ekrrgainskq
0038934 (Phosphotyrosine protein) phosphatases II 102-217 2.3e-18 62.0 In-house 54-170 (194) alignment 
Range on Protein: 102-217
Range on HMM: 54-170/194.0
KYKINSIVNLCD-EYQGPTQHYTQYGMQQLYVPVVDHF-EPDVEIIEKSIQFILKQIEL--GNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILL
..|.  ...|.  |    ...... |.. |  |..|..  |. ||. . .... . ..   |. |..|||||.||.| ...... |... |.| | ... 
nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

EKRkivRKQLYKQKNVNQYY
|||   ......|. .....
ekR...pgaipnqdyleall
subfamily_RNGTT_pd Subfamily RNGTT 102-220 2.3e-06 21.4 In-house 52-171 (189) alignment 
Range on Protein: 102-220
Range on HMM: 52-171/189.0
KYKINSIVNLCDEYQGP-TQHYTQYGMQQLYVPVVDHFE-PDVEIIEKSIQFILK--QIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILL
|.|.  ...|  . .   ... .. |...  . .  . | |. | ... |. . .  . .  . . .||. |  |.| ......   . .|.| | ..  
kvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFa

EKRKivrKQLYKQKNVNQYYSSY
. |.   . .||.. ...... |
kaRp...pGiykedylkellrrY
subfamily_PTEN_pd Subfamily PTEN 106-205 7.7e-13 43.8 In-house 62-161 (184) alignment 
Range on Protein: 106-205
Range on HMM: 62-161/184.0
NSIVNLCDEYQGPTQHYtqyGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIELG--NRVYIHCKAGRGRSGAIAICWIAYSRRVSLE-VAQKILLEKRKI
  | ||. |..  ....     .   .|. ||. | .|..|. .. | | .|    | | .|||||.||.| . .... .|. .. .  | ..  |.|  
ykiynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk

VRK
 .|
nkk
subfamily_VSP_pd Subfamily VSP 107-188 3.7e-07 24.3 In-house 77-157 (212) alignment 
Range on Protein: 107-188
Range on HMM: 77-157/212.0
SIVNLCDEYQGPTQHYTQygmQQLYVPVVDHFEPDVEII---EKSIQFILKQiELGNRVYIHCKAGRGRSGAIAICWIAYSRRVS
 .|||| | .   ... .   .   . . ||  | .| .    | ..  |.. .| | . |||| |.||.|.|  ... .|  ..
kvvnlcseraydekyfnn...rvkriliddhnvpkleellvftkevkewlek.dlknvlaihckGGkgrtGtivcalllaseife
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 120-184 2.2e-06 18.9 Pfam-A 94-158 (168) alignment 
Range on Protein: 120-184
Range on HMM: 94-158/168.0
QHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYS
. | |||.   . |. |   ||.    . .. .   ..   .  |||  | |||  .| | . | 
dlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllyl
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 120-184 2.2e-06 18.9 In-house 94-158 (168) alignment 
Range on Protein: 120-184
Range on HMM: 94-158/168.0
QHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYS
. | |||.   . |. |   ||.    . .. .   ..   .  |||  | |||  .| | . | 
dlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllyl
subfamily_CDKN3_pd Subfamily CDKN3 120-194 4.6e-06 20.3 In-house 93-168 (202) alignment 
Range on Protein: 120-194
Range on HMM: 93-168/202.0
QHYTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAY-SRRVSLEVAQK
. |.| |.   . |. |   ||.    | .. .   .. ...  .||  | |||  .. | . | .  .. . | .
dlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaid
subfamily_Laforin_pd Subfamily Laforin 121-203 6.5e-12 38.7 In-house 71-154 (183) alignment 
Range on Protein: 121-203
Range on HMM: 71-154/183.0
HYTQYGMQQLYVPVVDH-FEPDVEIIEKSIQFILKQIELGNRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKIV
 | . |.  ...|. |   |  || . ... ..   .| | .||.||.|| ||| ||   .. |    ||   |  || || .|
lykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPDC1_pd Subfamily PTPDC1 122-202 2.7e-10 35.0 In-house 78-157 (182) alignment 
Range on Protein: 122-202
Range on HMM: 78-157/182.0
YTQYGMQQLYVPVVDHFEPDVEIIEKSIQFILKQIELGnRVYIHCKAGRGRSGAIAICWIAYSRRVSLEVAQKILLEKRKI
... |.    ..  |.  . .| |   .. .   .. | .| .|| ||.|| | .  |.. |..|.. | | |.. .||  
lmeqgiyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk