Gene DDB_G0280073 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP034_AA protein Get Run
DdisP034_AA_147-303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_OCA_pd Subfamily OCA 146-297 1.4e-31 99.9 In-house 142-282 (282) alignment 
Range on Protein: 146-297
Range on HMM: 142-282/282.0
PQLSPPALFGTIEP--------LLYRTNSLYPANFPFI-KLLGLKTVVQLSPE-VPIKAVSSFFQENNINLIHLGLkswkvdiswkpltdelikECLEIV
 .| ||. |...|          |.|.    ..|.||. . |||||.. |..| |. ... .|.....|.|..|                    |.|...
yslvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn..................evlkdl

LNYDYYPLMITCtsgVHQTGVLVGCLRRLQNWNLTSILVEYKAFSGQSNTRYVNEQFIELFD
|. | |.....|   ...|......||.......|||. ||. |........ ....|||||
ldndnyavelsc...qaktdtvlkvLrkdkkygstsiyleyigFtledqeslksillielfd
0051082 (Phosphotyrosine protein) phosphatases II 148-286 3.1e-25 83.9 In-house 2-136 (151) alignment 
Range on Protein: 148-286
Range on HMM: 2-136/151.0
LSPPALFGTIEPLLYRTNSLYPANFPFIKLLGLKTVVQLSPEVPIKAVSSFFQENNINLIHLGLKSWKVDisWKPLTDELIKECLEIVLNYDYYPLMITC
||..  |. ... |||.. . .......| ||.||.| | .|....   ....|..|...|. . .|..     ||. . ..| ||..|. . .|. . |
lsdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdp..glplsfdavleflellldkkngpvlvHC

TSGVHQTGVLVGCLRRLQNWNLTSILVEYKAFSGqsNTR
..|.. ||.||.... |....| ..| ||... .  .  
saGkgRTGtlvalylmllgvsleealeeyrlkrp..gvv
Y_phosphatase2 Tyrosine phosphatase family 150-305 2.1e-43 140.0 Pfam-A 3-155 (165) alignment 
Range on Protein: 150-305
Range on HMM: 3-155/165.0
PPALFGTIEPLLYRTNSLYPANFPFIKLLGLKTVVQLSPEVPIKAVSSFFQENNINLIHLGLKSWKVDisWKPLTDELIKECLEIVLNYDYYPLMITCTS
||  |...|. |||     ..||.|.| | |||...||||   .    |..|..|.|.|. ..| | .  . .....|.|..|...|| . ||... |..
pplnFsaveselyrssyprasnfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkee..lveiksdllkkalklllnkenypvllhckr

GVHQTGVLVGCLRRLQNWNLTSILVEYKAFSGQsNTRYVNEQFIELFDVDLVTFPN
| |.||...||||.||.|.|.||| ||. |||. ..|.|.|.||| ||..|.   .
GkhrtglvigclRklqkWslasilnEyrrFsgs.kkrivdeefienfdselevekk
0045098 (Phosphotyrosine protein) phosphatases II 150-298 3.2e-07 25.5 In-house 18-269 (278) alignment 
Range on Protein: 150-298
Range on HMM: 18-269/278.0
PPALFGTIEPLLYRTNSL-----------------------------------------YPANFPFIKLLGLKTVVQLSPEVPIKAV-------------
..  ...|.| ||. |                                             ... ... || ...| | ..|. . .             
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

------------------------------SSFFQENNINLIHL-GLKSWKVDISW-KPLTDELIKECLEIVL------------NYDYYPLMITCTSGV
                               . ....... .|. .     |  .      .||.....| .             . .  |  . |  ||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

HQTGVLVGCLRRLQ----NWNLTSILVEYKAFSGQ-SNTRYVNEQFIELFDV
. ||.||..   |.    ...| ... |..   .. . .     .|.. | .
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0044763 (Phosphotyrosine protein) phosphatases II 153-301 3e-12 42.0 In-house 22-171 (178) alignment 
Range on Protein: 153-301
Range on HMM: 22-171/178.0
LFGTIEPLLYRTNSLYPANFPFIKLLGLKTVVQLSPEVP---IKAVSSFFQENNINLIHLGLKSWKVDIsWKPLTDELIkECLEIVLNYDYYPLMITCTS
 .  | | ||...   .......| ||....| |..|..   .|    ...|..|. .|...  ..|       ..|.. | .| .|. .  |  . |. 
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd.llehflefv.efieealdekggpvlVHCsa

GVHQTGVLVGC-LRRLQNWNLTSILVEYKAFSGqSNTRYVNEQFIELFDVDLV
||. .|.|| . | . ....| ... ....     ...    .....|.  | 
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0048179 (Phosphotyrosine protein) phosphatases II 154-296 5e-12 41.3 In-house 4-140 (144) alignment 
Range on Protein: 154-296
Range on HMM: 4-140/144.0
FGTIEPLLYRTNSLYPANFPFIKLLGLKTVVQLSPEVPIKAVSSFfqenNINLIHLGLKSWKVDiswkplTD-ELIKECLEIVLNY--DYYPLMITCTSG
.  | | ||. .  .. .....| ||..||. |..| .   .  .    .|...||..  . |       .. ||. |.||.. ..  . .|  . |. |
pseilpglylgslptaldlellkklgittvinlteeyepeflere....giqylhlpwpDhgvp......dllellleflefieealeeggpvlVHCsaG

VHQTGVLVGC-LRRLQNWNLTSILVEYKAFSGQSNTRYVNEQFIELF
|. ||.|| . | ......| ..| ....   ....     .|....
vgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLley
0048076 (Phosphotyrosine protein) phosphatases II 154-298 2.9e-11 38.7 In-house 4-140 (145) alignment 
Range on Protein: 154-298
Range on HMM: 4-140/145.0
FGTIEPLLYRTNSLYPANFPFIKLLGLKTVVQLspevpiKAVSSFFQENNINLIHLGLKSWKVDISWkpltdELIKECLEIVLNY---DyYPLMITCTSG
.  | | ||. .   . .....| ||..||. |          ... ...|....|..  . |  ..     ||. |.||.. ..   . .|  . |. |
pseilpglylgslptaldlellkdlgittvlnl......tselellerlgiqylylpwpDhgvpdll.....ellleflefieealkeg.gpvlVHCsaG

VHQTGVLVGC-LRRLQNWNLTSILVEYKAFSGQSNTRYVNEQFIELFDV
|. ||.||.. | .|....| ..| ....   .....    .|...|. 
vgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
0049772 (Phosphotyrosine protein) phosphatases II 155-281 9.9e-10 34.1 In-house 155-255 (314) alignment 
Range on Protein: 155-281
Range on HMM: 155-255/314.0
GtiepllyrtNSLYPANFPFIKllglktvvqlspevpiK--AVSSFFQENNINLIHLGLKSWKVDiswkplTDELIKECLEIVLNY-DYYPLMITCTSGV
|         | . .|.....|                .     ..|....|..... .  . ..      ..| ..|.||..... . .|. . |..|.
g.........neptaadlellk................eelydpelferlgikylripvpDgsap......lledfdeflefieeadkggpvlvHCkaGk

HQTG--VLVGCLRRLQNWNLTSILVEYKAFSG
. ||  |....| .|....|  .| ....   
gRtgtfvvaaylmkllgvsleealedvrlkRp
0042113 (Phosphotyrosine protein) phosphatases II 157-295 5e-12 41.2 In-house 50-237 (245) alignment 
Range on Protein: 157-295
Range on HMM: 50-237/245.0
IEPLLYRTNSLYPANFP----FIKLLGLKTVVQLSPEVPIKAV----------------------------------------SSFFQENNINLIHLGLK
| | ...|.   | ...    ... ||..|.| |..|.. . |                                         .... ..|.. .|.  
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

SWKVDISwKPLTDELIKECLEIVLNYDYYPLMITCTSGVHQTGVLVGCLR------RLQNWNLTSILVEYKAFSGQSNTRYVNEQFIEL
  .|  .   | ........... . . .|... |. ||. ||.......      ......| ... |.. . ... .     .|.  
dhgvpdl.lellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
0036282 (Phosphotyrosine protein) phosphatases II 157-278 1.9e-09 33.0 In-house 15-144 (174) alignment 
Range on Protein: 157-278
Range on HMM: 15-144/174.0
IEPLLYRTNSLYPaNFPFIKLLGLKTVVQLSPEVPIK---------AVSSFFQENNINLIHLGLKSWKVDISWKplTDELIKECLEIVLNYDYYPLMITC
| | |....   . .....| ||..|||.| .|.. .           .... ...|....|.     |  . .   .|..|.. |.... .  |. . |
itprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHC

TSGVHQTGVLVGCLRRLQNW--NLTSILVEYKA
. ||. ||.||.... |...  .|  .|  ...
saGvgRtGtlvaaylmlrglleslvdaldlvre
0041856 (Phosphotyrosine protein) phosphatases II 157-303 7.5e-09 30.9 In-house 22-173 (182) alignment 
Range on Protein: 157-303
Range on HMM: 22-173/182.0
IEPLLYRTNSLY--------------PANFPFIKLLGLKTVVQLSpevPIKAVSSFFQENNINLIHLGLKSWKVDIswKPLTDELIKECLEivlnyDYYP
| . ||. .                 .......| || .|.| |.   .     .... ..|....|.   . |     . . ..|.|.||     .  |
Inanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd..ldelldfieevle.....eggp

LMITCTSGVHQTGVLVGC-LRRLQNWNLTSILVEYKAFSGQSNTRYVNEQFIELFDVDLVTF
  . |. ||. ||.||.. | . ....|.... ...    .. ..    .|. |.  .|. .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0051429 (Phosphotyrosine protein) phosphatases II 158-280 1.1e-14 50.3 In-house 21-190 (272) alignment 
Range on Protein: 158-280
Range on HMM: 21-190/272.0
EPLLYRTNSL---YPANFPFIKLLGLKTVVQLSPEVPIKAVSSFFQENNINLIHLGLKSWKVDISWKP--------------------------------
. .|||.. .    .|.|...| ||.||.| | .|. ....  ..   .|...|| . .. .                                      
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

--------------LTDELIKECLEIVLNydYYPLMITCTSGVHQTGVLVGCLRRLQNWNLTSILVEYKAFS
                .| ..| ||..|.   .|... |..|.. ||..| .|. |....|. |. .|  ..
evmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn
0040439 (Phosphotyrosine protein) phosphatases II 169-293 8.8e-08 27.5 In-house 68-238 (249) alignment 
Range on Protein: 169-293
Range on HMM: 68-238/249.0
PANFPFIKLLGLKTVVQLSPEVPIKAVSSF-------------------------------------FQENNINLIHLGLKSWKvDISW---KPLTDELI
.... ... || ...| |...|. . .  .                                        . .   |.   .|  | .     . ....|
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfi

KECLEIVLNY-DYYPLMITCTSGVHQTGVLVGCLR------RLQNWNLTSILVEYKAFSGQSNTRYVNEQFI
....... .. .  |... |. ||. ||......       . ....| ... ...   ... . .   .|.
eavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 173-285 3.6e-08 28.7 In-house 106-261 (278) alignment 
Range on Protein: 173-285
Range on HMM: 106-261/278.0
PFIKLLGLKTVVQLSPEVPIKA--------------------VSSFFQENNINLIHLGLKSWKVDIS--------------WKPLTDELIKECLEIVLNY
 ... || .|.| | ..|  .                     . .. ..... ...| ..  . . |                | . .|. . |..|...
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

---DYYPLMITCTSGVHQTGVLVGCLR------RLQNWNLTSILVEYKAFSGQSNT
   .  |... |. ||. ||.......      . ....| ... |.. . ... .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavq
0039614 (Phosphotyrosine protein) phosphatases II 173-296 7.7e-08 27.6 In-house 119-284 (297) alignment 
Range on Protein: 173-296
Range on HMM: 119-284/297.0
PFIKLLGLKTVVQLSPEVPIK-------------------AVSSFFQENNINLIHLGLK--------------SWKvDISWKPLTDELIKECLEIVLNY-
 ... .| ...| | ..|. .                    . .......... .| ..              .|  | .  |... |.. . ..   . 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.dhgvppslellleflelvreala

---DYYPLMITCTSGVHQTGVLVGCLR------RLQNWNLTSILVEYKAFSGQSNTRYVNEQFIELF
   .  |  . |. ||. ||.......      . ..... ... |..   ... .     .|.  .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0040438 (Phosphotyrosine protein) phosphatases II 174-301 1.1e-08 30.2 In-house 105-276 (317) alignment 
Range on Protein: 174-301
Range on HMM: 105-276/317.0
FIKLLGLKTVVQLSPEVPIK---------------------AVSSFFQENNINLIHLGLKS-----------------WKVDISWkplTDELIKECLEIV
... .|....| | .... .                      . |......|.| .| ..                     ..     . .|. . ||.|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp...spdllldfleav

LNY---DYYPLMITCTSGVHQTGVLVGCLR------RLQNWNLTSILVEYKAFSGQSNTRYVNEQFIELFDVDLV
 ..   .  |... |. ||. ||.......      . ......... |.... ... . .   .|.  .  ...
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl