Gene DDB_G0281953 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP035_AA protein Get Run
DdisP035_AA_2-156 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_OCA_pd Subfamily OCA 3-150 4.9e-39 124.4 In-house 143-282 (282) alignment 
Range on Protein: 3-150
Range on HMM: 143-282/282.0
HHIPPLNFGMVAD--------DLYRSGQPNELNFPFL-EKLQLKKIIFLAPDD-PSQQFQNFVEDQDIELIHLGMdthqnpwnpiseeiviSALKIILNP
...||.||..|..        .|.|...|.|.|.||| ..|.|| ...|.. . .......|.....|.|..| .                ..||..|. 
slvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn................evlkdlldn

DNYPLHIMCnlgRHRTGTVVGCLRKLQRWNLTSIFEEYRRFAG-SKVKLLNEQFIELFD
|||.....|   ...|.||...|||......|||..||..|.. .. .| ....|||||
dnyavelsc...qaktdtvlkvLrkdkkygstsiyleyigFtledqeslksillielfd
0040439 (Phosphotyrosine protein) phosphatases II 3-133 2.8e-12 42.3 In-house 18-224 (249) alignment 
Range on Protein: 3-133
Range on HMM: 18-224/249.0
HHIPPLNFGMVADDLYRSGQPN----------------------------ELNFPFLEKLQLKKIIFLAPDDPSQQFQNF--------------------
..|.|... .|    .... ..                            | .. .| .|. . |. | .... .. . .                    
pdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtlls

-----------------VEDQDIELIHLGMDTHQNPWNPISEEIVISALKIILN-----PDNYPLHIMCNLGRHRTGTVVGCLR------KLQRWNLTSI
                  ......  |. .        | | |.... ......     |.. |. ..|. | .||||.....       | ....| ..
vevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleea

FEEYRRF
....|. 
vkllrsq
0046846 (Phosphotyrosine protein) phosphatases II 3-133 4.6e-09 31.8 In-house 5-150 (176) alignment 
Range on Protein: 3-133
Range on HMM: 5-150/176.0
HHIPPLNFGMVADDLYRSGQP----------NELNFPFLEKLQLKKIIFLAPDDPSQ-----QFQNFVEDQDIELIHLGMDTHQNPWNpISEEIVISALK
.....|..  . ..|. .. |           . .. .| .|. . .. |  .   .     .. . .|. .|. .||... |. |      . .. ...
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

IILNPDnYPLHIMCNLGRHRTGTVVGCLRKLQ--RWNLTSIFEEYRRF
  |. .  |  . |  |. ||||.| ..       ...  .....|. 
ealkeg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreq
0051082 (Phosphotyrosine protein) phosphatases II 4-150 1e-36 121.1 In-house 2-148 (151) alignment 
Range on Protein: 4-150
Range on HMM: 2-148/151.0
HIPPLNFGMVADDLYRSGQPNELNFPFLEKLQLKKIIFLAPDDPSQQFQNFVEDQDIELIHLGMDTHQNPWNPISEEIVISALKIILNPDNYPLHIMCNL
. ...||..| . |||||.| . ....|..|..| |. | .... . . .......||..|. .. ...|  |.| ..|...|...|...|.|. . |. 
lsdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsa

GRHRTGTVVGCLRKLQRWNLTSIFEEYRRFAGSKVKLLNEQFIELFD
|..||||.|.....|....| ...||||.. . .|   ......||.
GkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqflfqlfa
0036282 (Phosphotyrosine protein) phosphatases II 4-148 6e-18 60.6 In-house 6-162 (174) alignment 
Range on Protein: 4-148
Range on HMM: 6-162/174.0
HIPPLNFGMVADDLYRSGQPNElNFPFLEKLQLKKIIFLAPDDPSQ---------QFQNFVEDQDIELIHLGMDTHQNPWNPISEEIVISALKIILNPDN
. .||.. .. . |.... | . ....| .|... .. | .  . .          .... |. .|....|... |. |  .| .|.|  . ........
naspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpg

YPLHIMCNLGRHRTGTVVGCLRKLQRW--NLTSIFEEYR--RFAGSKVKLLNEQFIEL
 |. . |. |..||||.|.... |...  .|  ... .|  |.  ...    .|.. |
gpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
0043336 (Phosphotyrosine protein) phosphatases II 4-136 4.1e-14 48.2 In-house 53-258 (278) alignment 
Range on Protein: 4-136
Range on HMM: 53-258/278.0
HIPPLNFGMV------------------------ADDLYRSGQPNELN----FPFLEKLQLKKIIFLAPDDPSQQ--------------------FQNFV
.|.|... .|                         .. .... |.. .    . .. .|. . |. | ...  ..                    .... 
dilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkee

EDQDIELIHLGMDTHQNPWNPI----------------SEEIVISALKIILN---PDNYPLHIMCNLGRHRTGTVVGCLR------KLQRWNLTSIFEEY
...|. ...| .  .....  .                | ..... ||....   ..| |....|. | .||||......      | ....| ....|.
hlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RRFAGS
|.. ..
reqRpg
0039614 (Phosphotyrosine protein) phosphatases II 4-135 4.5e-12 41.5 In-house 64-269 (297) alignment 
Range on Protein: 4-135
Range on HMM: 64-269/297.0
HIPPLNFGMV--------------------------ADDLYRSGQPNELN----FPFLEKLQLKKIIFLAPDDPSQ-------------------QFQNF
.|.|... .|                           .. .... |.. .    . .. ... . |. | . .. .                    . ..
dilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkv

VEDQDIELIHLGMDTH----------Q----NPWNPISEEIVISALKIILN-----PDNYPLHIMCNLGRHRTGTVVGCLR------KLQRWNLTSIFEE
 ..... . .| .  .                   | | |.....|... .     |.. |  ..|. | .||||......      | ..... ....|
ehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke

YRRFAG
.|.  .
lreqRp
Y_phosphatase2 Tyrosine phosphatase family 5-162 1.5e-59 192.5 Pfam-A 2-159 (165) alignment 
Range on Protein: 5-162
Range on HMM: 2-159/165.0
IPPLNFGMVADDLYRSGQPNELNFPFLEKLQLKKIIFLAPDDPSQQFQNFVEDQDIELIHLGMDTHQNPWNPISEEIVISALKIILNPDNYPLHIMCNLG
.|||||..|.  ||||..|.. ||.||..|.||.|| | |.. ||.  .|.| . |.|.|. ..  .... .| .. .  |||..|| .|||. ..|. |
vpplnFsaveselyrssyprasnfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrG

RHRTGTVVGCLRKLQRWNLTSIFEEYRRFAGSKVKLLNEQFIELFDTDLVTYNNAPQW
.||||.|.|||||||.|.|.||..|||||.||| . ..|.||| ||..|.  .. ...
khrtglvigclRklqkWslasilnEyrrFsgskkrivdeefienfdselevekknkkl
0044763 (Phosphotyrosine protein) phosphatases II 5-156 4.2e-21 70.8 In-house 18-173 (178) alignment 
Range on Protein: 5-156
Range on HMM: 18-173/178.0
IPPLNFGMVADDLYRSGQPNELNFPFLEKLQLKKIIFLAPDDP---SQQFQNFVEDQDIELIHLGMDTHQNPWNPISEEIVISALKIILNPDNYPLHIMC
....|. .. ..||....|.. ....| .| .. |. |.....    . .. ..|. .|. .|.... | .|  .   . .. ... .|.... |  . |
sdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHC

NLGRHRTGTVVGC-LRKLQRWNLTSIFEEYRRFAGSKVKLLNEQFIELFDTDLVTY
. |..|.||.| . | | ....| ...|..|.           .....|.  |  .
saGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllke
0042113 (Phosphotyrosine protein) phosphatases II 5-136 8.6e-21 69.9 In-house 37-224 (245) alignment 
Range on Protein: 5-136
Range on HMM: 37-224/245.0
IPPLNFGMV-----ADDLYRSGQPNELNFP----FLEKLQLKKIIFLAPDDPSQQF----------------------------------------QNFV
 .. |...|      . ......| . ...    .| .|... |. | .... ..                                         ... 
sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdde

EDQDIELIHLGMDTHQNPW-NPISEEIVISALKIILNPDNYPLHIMCNLGRHRTGTVVGCLR------KLQRWNLTSIFEEYRRFAGS
. ..| . .|... |. |.   . ....  ..|.. ...|.|. ..|. |..||||......      |.....| ....|.|.. . 
srevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpg
0045098 (Phosphotyrosine protein) phosphatases II 5-153 7.5e-12 40.7 In-house 17-269 (278) alignment 
Range on Protein: 5-153
Range on HMM: 17-269/278.0
IPPLNFGMVADDLYRSGQP-----------------------------------------NELNFPFLEKLQLKKIIFLAPDDPSQQF------------
... ..... . ||.....                                          . .. .| .|. . |. |..  . ..             
lllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl

-------------------------------QNFVEDQDIELIHL-GMDTHQNPWNPISE---EIVISALKIIL------------NPDNYPLHIMCNLG
                               ..  |   .. .|. ... |  | .||.    |..   .. .             .... |  . |. |
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

RHRTGTVVGCLRKLQ----RWNLTSIFEEYRRFAGSKVKLLNEQFIELFDTDL
 .||||.|..   |.    ...| ....|.|.  .  .    ||.. |..  |
vgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0037934 (Phosphotyrosine protein) phosphatases II 6-134 3.9e-12 41.7 In-house 35-220 (243) alignment 
Range on Protein: 6-134
Range on HMM: 35-220/243.0
PPLNFGMVADDLYRSGQPNEL--------NFPFLEKLQLKKIIFLAPDDPSQQFQNF-------------------------------VEDQD-IELIHL
 ..|. .| . |.....| .         .. .| .|. . |. | ...  .... .                               .|  |  .| .|
inanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrl

GMDTHQNPWNP----ISEEIVISALKIILN-----------PDNYPLHIMCNLGRHRTGTVVGCLRKLQ--RWNLTSIFEEYRRFA
..  |. ||       | |.... |... .           ... |. ..|  |..||||.. ..  |.  ...| ......|.  
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqR
0048076 (Phosphotyrosine protein) phosphatases II 7-134 6.7e-19 63.4 In-house 1-122 (145) alignment 
Range on Protein: 7-134
Range on HMM: 1-122/145.0
PLNFGMVADDLYRSGQPNELNFPFLEKLQLKKIIFLapddpsQQFQNFVEDQDIELIHLGMDTHQNPwnpISEEIVISALKII--LNPDNYPLHIMCNLG
| .. .. ..||....|. |....|..|... .. |         ....|...|....|... |. |    . |.....|..|  . ....|  . |. |
pywpseilpglylgslptaldlellkdlgittvlnl......tselellerlgiqylylpwpDhgvp...dllellleflefieealkeggpvlVHCsaG

RHRTGTVVGC-LRKLQRWNLTSIFEEYRRFA
..||||.|.. | .|....| ...|..|.  
vgRtgtlvaaylmlllgvsleealelvrsqr
0041856 (Phosphotyrosine protein) phosphatases II 7-145 3.5e-17 58.0 In-house 16-161 (182) alignment 
Range on Protein: 7-145
Range on HMM: 16-161/182.0
PLNFGMVADDLYRSGQPN--------------ELNFPFLEKLQLKKIIFLApddPSQQFQNFVEDQDIELIHLGMDTHQNPWnpisEEIVISALKIILNp
.... .. . ||....|.              . ....| .|. . |. |.   . . . ...|.. |....|... |  |      ..... ....|. 
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.

DNYPLHIMCNLGRHRTGTVVGC-LRKLQRWNLTSIFEEYRRFAGSKVKLLNEQF
.. |  . |. |..||||.|.. | | ....|.......|.     |  .|  |
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyf
0051429 (Phosphotyrosine protein) phosphatases II 8-151 2.1e-23 78.8 In-house 15-210 (272) alignment 
Range on Protein: 8-151
Range on HMM: 15-210/272.0
LnFGMVADD-LYRSGQP---NELNFPFLEKLQLKKIIFLAPDDPSQQFQNFVEDQDIELIHLGMDTHQNPWNPISE------------------------
. ...| .. |||||.|   .. .|..|..|..| |. | ...  .... . . ..|...|| .  .  |.  .                          
y.grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltll

------------------------EIVISALKIILNpdNYPLHIMCNLGRHRTGTVVGCLRKLQRWNLTSIFEEYRRF---AGSKVKLLNEQFIELFDT
                        | ....|...|.  ..|. . |. |..|||||| .|. |....|. |...|...   .   |. | .|.   . |
lsagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqt
0048179 (Phosphotyrosine protein) phosphatases II 9-135 1.4e-18 62.5 In-house 3-125 (144) alignment 
Range on Protein: 9-135
Range on HMM: 3-125/144.0
NFGMVADDLYRSGQPNELNFPFLEKLQLKKIIFLAPDDPSQQFQNFvedqDIELIHLGMDTHQNPWNPiseEIVISALKII--LNPDNYPLHIMCNLGRH
|. .. ..||....|  |....| ||... .| |... . . . ..     |...||... |. |  .   |.....|..|  . ....|  . |. |..
npseilpglylgslptaldlellkklgittvinlteeyepeflere....giqylhlpwpDhgvpdll...ellleflefieealeeggpvlVHCsaGvg

RTGTVVGC-LRKLQRWNLTSIFEEYRRFAG
||||.| . | |.....| ......|.   
Rtgtlvaaylmkklglsleealalvrsrrp
0049772 (Phosphotyrosine protein) phosphatases II 18-147 3.2e-16 55.4 In-house 155-264 (314) alignment 
Range on Protein: 18-147
Range on HMM: 155-264/314.0
YrsGQPNELNFPFLEklqlkkiiflapddPSQQFQNFVEDQDIELIHLGMDTHQNPwnpiSEEIVISALKIILN-PDNYPLHIMCNLGRHRTG--TVVGC
.  ..|.. ....|.              . .  ....|.. |..... .. .. |    ..|.. ..|..|.. ....|. . |. |..|||   |...
g..neptaadlellk..............eelydpelferlgikylripvpDgsap....lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaay

LRKLQRWNLTSIFEEYRRFAGskvKLLNEQFIE
| ||....|  ..|..|.         |. |||
lmkllgvsleealedvrlkRp...inpnpgfie
0049260 (Phosphotyrosine protein) phosphatases II 20-132 1.7e-09 33.1 In-house 18-127 (152) alignment 
Range on Protein: 20-132
Range on HMM: 18-127/152.0
SGQPNELNFPFLEKLQLKKIIFLAPDDPsqqFQNFVEDQDIELIHLGMDTHQNPWNPISEEIVISALKIILNPDNYPLHIMCNLGRHRTGTVVGCLRKLQ
 ... . .. .| .|. . |. |  ...   .  . ..| |. .|| .. |  | ...  .... ......  .. |  . |  |  ||||.| ..  |.
gpntladfwrmlkelgittivmltelle...lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylmll

RWNLTSIFEEYRR
...|  ... .|.
gvsleeavalvre
0043147 (Phosphotyrosine protein) phosphatases II 20-132 8.5e-09 30.9 In-house 29-138 (172) alignment 
Range on Protein: 20-132
Range on HMM: 29-138/172.0
SGQPNELNFPFLEKLQLKKIIFLAPDdpsQQFQNFVEDQDIELIHLGMDTHQNPwN-PISEEIVISALKIILNPDNYPLHIMCNLGRHRTGTVVGCLRKL
 . . . .. .| .|. . |. | .    .    ..|...|....|... |  | .  . .|..    ..... .. |  . |  |  ||||.| ..  |
lrntladfwrmlkelgithivnltel...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml

QRWNLTSIFEEYRR
....|  .....|.
lglsleeavalvre
0045450 (Phosphotyrosine protein) phosphatases II 29-133 5e-09 31.8 In-house 125-282 (307) alignment 
Range on Protein: 29-133
Range on HMM: 125-282/307.0
PFLEKLQLKKIIFLAPDDPSQQ----------------------FQNFVEDQDIELIHLGMDTH-----------------QNPWNPISEEIVISALKII
 .| ... . |. | ....  .                      . .. ..... . .| .  .                  .   | | |.... ....
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

LN-----PDNYPLHIMCNLGRHRTGTVVGCLRKLQR---------WNLTSIFEEYRRF
..     |.. |  ..|. |  ||||.....  |..         ..| ......|. 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreq
0040438 (Phosphotyrosine protein) phosphatases II 30-134 2.2e-12 42.3 In-house 105-255 (317) alignment 
Range on Protein: 30-134
Range on HMM: 105-255/317.0
FLEKLQLKKIIFLAPDDPSQ---------------------QFQNFVEDQDIELIHLGM-------------------DTHQNPWnpiSEEIVISALKII
.. ..... |. | . .. .                     ......|...|.| .| .                   . |  |    | ..... |...
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp...spdllldfleav

LN---PDNYPLHIMCNLGRHRTGTVVGCLR------KLQRWNLTSIFEEYRRFA
 .   ... |. ..|. | .||||......      | ..........|.|.. 
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR
0036941 (Phosphotyrosine protein) phosphatases II 75-132 9.2e-07 23.9 In-house 183-254 (297) alignment 
Range on Protein: 75-132
Range on HMM: 183-254/297.0
NPISEEIVISALKIILN-----PDNYPLHIMCNLGRHRTGTVVGCLR---------KLQRWNLTSIFEEYRR
 | | ..... .. ...     |.. |  ..|. | .|.||....           | ..... ... ..|.
vpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklRe