Gene DDB_G0285191 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP036_AA protein Get Run
DdisP036_AA_88-458 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051429 (Phosphotyrosine protein) phosphatases II 82-172 3.5e-11 38.8 In-house 1-86 (272) alignment 
Range on Protein: 82-172
Range on HMM: 1-86/272.0
INLEAISNFRSLGGIpigdgQNVVRPGVVCRSAGPTNATVSDeFWLLEVLNIKTLIDLRTSWENKTIS-PVRKFEDNFIQYSIKDDGRPSPP
..|. . |.| .||       .||.||.. ||.||...|. | || |. |.||| .|||. .| .    .      ......| ||. |.. 
lplsgyiNardvggy.....grvvkpgrlyrsggplpltaad.fwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptil
0049772 (Phosphotyrosine protein) phosphatases II 89-473 4.8e-12 41.7 In-house 120-270 (314) alignment 
Range on Protein: 89-473
Range on HMM: 120-270/314.0
NFRSLGG---------------------IPIGDGQNvvrpgvvcrsagptnatvsDEFWLLEVLNIKtlidlrtswenKTISPVRKFEDNFIQY---SIK
|.| ...                     ..| ||..                   .| .  .. ..|           . . .  .||.. |.|    . 
nvrdivmsrdevladelsrLdaAlgKtpllildgng...................neptaadlellk...........eelydpelferlgikylripvp

DDGRPSPPSqrsqisselanskgsnlgnsglgnsglgnsgmgnnnlgnsgmgnnsglgnsgmgnngnnnlnnsgfnnstnvnennnlggslssnsnnngn
|.. |..                                                                                             
Dgsaplled...........................................................................................

kspnltssnsngsgggvslrksgggipvaierknekqkdmeeqrngilwriynrnltpeeltklrshssgvlrkrfciplinnkfflegvyatapndtkl
                                                                                                    
....................................................................................................

kcnaaryllfndqiggymlmnhlndlgiiemykltliytkeeILTIFRILKN-PDNYPIMYYCSLGKDRTG--MVSALLLSALGVSREVVIDDYSKSEAn
                                          .. ....... ....|.   |. ||.|||  .| |.|...|||| | ...|. .    
..........................................fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.

IA---QFIDQIKKYF
|     || | . | 
inpnpgfieqleqye
Y_phosphatase3 Tyrosine phosphatase family 89-176 7.4e-11 37.3 Pfam-A 1-86 (164) alignment 
Range on Protein: 89-176
Range on HMM: 1-86/164.0
NFRSLGGIPIGDGQnVVRPGVVCRSAGPTNATVSDEfWLLEVLNIKTLIDLRTSWENKTISPVRKFEDNFIQYSIKDDGRPSPPSQRS
||| |||.|. ||.  |||||. |||  ...| .|    |. |.||| .|||...| .. .     . ....... .. . || . ..
NfRDlGgyptadgr.tvrpgvlyRSaalsklteadl.aaLaelgiktvvDLRseeEvekepdklpegvkyvnlpvlkeeaespeelae
Lamprin Lamprin 190-218 6.7e-06 12.3 Pfam-A 43-71 (138) alignment 
Range on Protein: 190-218
Range on HMM: 43-71/138.0
LGNSGLGNSGLGNSGMGNNNLGNSGMGNN
||  |||  ||| .|.|   ||  |.|  
lgygglgygglgvaglgvaglgygglgyp
subfamily_OCA_pd Subfamily OCA 386-528 1.3e-25 80.3 In-house 146-278 (282) alignment 
Range on Protein: 386-528
Range on HMM: 146-278/282.0
HLNDLGIIEMYKLtliytKEEILTIFR-ILKNPDNYPIMYycslgkDRTGMVSALLLSALGVSREVVIdDY-SKSEANIAQFID-QIKKYFTRVGLAKDE
 .......|.||      |..|....| .|....|.|...      ||.|. .||.|.| .|.|| .. |. ..|| ..... .  .|..... ..|   
pprnfslveeykd.....kpvisgllrlllpeeenlpfLi......drlglktaliLdaeeveretia.dflasseiklvslrnevlkdlldndnyavel

FVRSHRWTMEGLLTWiDKMYGSVPGYLDNIGFSYQEQEELKANLIV
.......|. ..|.. ||.|||.  ||..|||....||.|| .|..
scqaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksilli
0042113 (Phosphotyrosine protein) phosphatases II 388-469 9.1e-09 30.6 In-house 144-232 (245) alignment 
Range on Protein: 388-469
Range on HMM: 144-232/245.0
NDLGIIEMYKLT-LIYTKEEILTIFRILKNPDNYPIMYYCSLGKDRTGMVSALLL------SALGVSREVVIDDYSKSEANIAQFIDQI
  |.. ..   . | .  . .  . ..|....|.|..  || |..|||.. |..|      . |||| | ..... .   .. |  .|.
hylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy
Y_phosphatase3 Tyrosine phosphatase family 392-458 2.4e-17 58.4 Pfam-A 98-163 (164) alignment 
Range on Protein: 392-458
Range on HMM: 98-163/164.0
IIEMYKLTLIYTKEEILTIFRILKNPDNyPIMYYCSLGKDRTGMVSALLLSALGVSREVVIDDYSKS
. |.|.  |   |... .....| .... |... |. ||||||.|.|||||.|||..|....||. .
maeayreiledekkayrkvlealaeeeg.pvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt
0051082 (Phosphotyrosine protein) phosphatases II 394-470 1.4e-13 46.1 In-house 67-143 (151) alignment 
Range on Protein: 394-470
Range on HMM: 67-143/151.0
EMYKLTLIYTKEEILTIFRILKNPDNYPIMYYCSLGKDRTGMVSALLLSALGVSREVVIDDYSKSEANIAQFIDQIK
 .   .|  . ...| ....| ...|.|.  .|| ||.|||.. ||.| .|||| | ....| ..  .. |  .|. 
dwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqfl
0051429 (Phosphotyrosine protein) phosphatases II 396-527 5.6e-29 97.0 In-house 106-272 (272) alignment 
Range on Protein: 396-527
Range on HMM: 106-272/272.0
YKLTLIYT-----------------------KEEILTIFRILKNpdNYPIMYYCSLGKDRTGMVSALLLSALGVSREVVIDDYSKSEANIAQFIDQIKKY
..|.|...                       .|..|.....| .  ..|... || ||||||.|.||||..||||.|...||| ...  ...........
rellltlllsagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraq

FTRVGLAKD--------------EFVRSHRWTMEGLLTWIDKMYGSVPGYLDNIGFSYQEQEELKANLI
.  ..   .              ..  ... ...  |..||. |||| ||| ..|.| .|.| |...|.
rpgavqteeqylflyeallellrsllsvraeyllaaldaideeyGsvegYLrdlglseeelerLrellL
Y_phosphatase2 Tyrosine phosphatase family 403-456 6.9e-06 18.0 Pfam-A 75-128 (165) alignment 
Range on Protein: 403-456
Range on HMM: 75-128/165.0
TKEEILTIFRILKNPDNYPIMYYCSLGKDRTGMVSALLLSALGVSREVVIDDYS
.....  ....| | .|||..  |. || |||.| . |    . |  .....| 
ksdllkkalklllnkenypvllhckrGkhrtglvigclRklqkWslasilnEyr
0043336 (Phosphotyrosine protein) phosphatases II 404-469 5.5e-07 24.8 In-house 192-266 (278) alignment 
Range on Protein: 404-469
Range on HMM: 192-266/278.0
KEEILTIFRILKN---PDNYPIMYYCSLGKDRTGMVSALLL------SALGVSREVVIDDYSKSEANIAQFIDQI
 . .| . .....   ..| |..  || |..|||.. ||.|      . .||. | ..... .  ... |  .|.
lsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy
Y_phosphatase3C Tyrosine phosphatase family C-terminal region 481-527 7.4e-12 34.7 Pfam-A 17-68 (68) alignment 
Range on Protein: 481-527
Range on HMM: 17-68/68.0
DE----FVRS-HRwTMEGLLTWIDKMYGSVPGYL-DNIGFSYQEQEELKANLI
.|    .. .  . ..|. |..||. |||| ||| ...|.| ...|.|...|.
realrpllgvree.yleaaldtideryGsvegYLeeaLGlseedierLRerlL