Gene DDB_G0275865 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP040_AA protein Get Run
DdisP040_AA_14-217 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 15-210 5.8e-23 77.5 In-house 26-299 (307) alignment 
Range on Protein: 15-210
Range on HMM: 26-299/307.0
SNELGEEINKQVNSTV----LKIRTQVSENNTTIRFKD-------------------------------------GEFDLDLSYI---------------
 . | .|..| .. ||        ..  || .  |.||                                     . .||.. .|               
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

-------------------TERIIAMSFPSEDTVINstwYRNsrvDVKKMLDKYHRDHYLIINLTEKSYDSSFFGGRVHHIGC---VDNHSP-SLGLLLY
                   . ...|. .|.|.....   |.|   .. ..|...| |.| . .|. . .| .... .|.|. .    | . | |.  || 
mlweqgvtvivmltelvelgrekcaqywPdegeelt...ygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

AVQVIHKWLSED-PKNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKE-------EALQLFASQRttsKVGVKVPSQLRYIDYV
 .. ..|.|.|. ....|..|| ||.||.||.|.|||. .. | ...       ||..|. .||     .|  |.|.|.. ..
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea
subfamily_VSP_pd Subfamily VSP 32-215 2.5e-48 158.8 In-house 15-199 (212) alignment 
Range on Protein: 32-215
Range on HMM: 15-199/212.0
KIRTQVSENNTtiRFKDGEFDLDLSYITERIIAMSFPSEDtviNSTWYRNSRVDVKKMLDKYHRDHYLIINL-TEKSYDSSFFGGRVHHIGCVDNHSPSL
 .|  ||||    |..   |||||.|.|||||||||||     . . |||   .| ..||. ||||| ..|| .|..|| ..|  ||..|   |   |.|
aarrlvsenkr..rytqdGfdldltyvteriiamsfpssG...kqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkl

GLLLYAVQVIHKWLSEDPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKEEALQLFASQRTTSKV-----GVKVPSQLRYIDYVHQLVT
  ||.  . ...||..|.|||.||||  | ||.||.. |.||.|    . .|.|. |...||  ..     ||. ||| ||..|..|..|
eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvkt
subfamily_PTEN_pd Subfamily PTEN 33-218 1.1e-70 232.4 In-house 2-183 (184) alignment 
Range on Protein: 33-218
Range on HMM: 2-183/184.0
IRTQVSENNttIRFKDGEFDLDLSYITERIIAMSFPSeDTVinSTWYRNSRVDVKKMLDKYHRDHYLIINL-TEKSYDSSFFGGRVHHIGCVDNHSPSLG
.|..||...  .|||. ..|||||||||.||||..|. ...  ...||||  ||.|.|.|.|.||| |.|| .|..|||. | |||..... |...|.| 
lrkivskkk..krfkedgldLDlsyiteniiamgyPa.ekl..ealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppple

LLLYAVQVIHKWLSEDPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKEEALQLFASQRTTSKVGVKVPSQLRYIDYVHQLVTSQR
||  .|. |.|||.||.||||..|| || ||.|.|||||||.||.  ..||||.|||..||..| ||..|||.||..|...|.....
lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleeek
0042113 (Phosphotyrosine protein) phosphatases II 34-211 2.1e-27 91.5 In-house 16-239 (245) alignment 
Range on Protein: 34-211
Range on HMM: 16-239/245.0
RTQVSENNTTIRFKDGEFDLDLSYI----------TERIIAMSFPSEDTVI---NSTWYRNSRVDV-----------------------------KKMLD
.  .  ..| ..... ..|||..||          |...||...|...||    .  |  .... |                              ..|.
sdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtlls

KYHRDHYLIINLTEK--SYDSSFFGGRVHHIGCVDNHSPS-LGLLLYAVQVIHKWLSEDPKNVVAIHCLAGLGRSGTLIVAYLLT----SLYEGRKEEAL
 .| |.| . .|. .   .| |... ..|.... |.. |. | ||| ... ..|.|.||....|..|| ||.||.||.|.|||.     ....   |||.
eehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeav

QLFASQRttsKVGVKVPSQLRYIDYVH
. . |||      |  |||.|.. ...
kelrsqR...pgavqtpsqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 37-210 7.9e-27 89.8 In-house 55-272 (278) alignment 
Range on Protein: 37-210
Range on HMM: 55-272/278.0
VSENNTTIRFKDGEFDLDLSYI----------TERIIAMSFPSEDTV---INSTWYRNSRVDVK----------------------------KMLDKYHR
.  ... ..... ..|||..||          ....||...|...||   ..  |  .... |                             ..|. .| 
lpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehl

DHYLIINLTEK--SYDSSFFGGRVHHIGCVDNHSP-SLGLLLYAVQVIHKWLSeDPKNVVAIHCLAGLGRSGTLIVAYLLT----SLYEGRKEEALQLFA
|.| ...|. .   .. |... ..|..|  |.. | || |||  .......|. |....|..|| ||.||.||.|..|||     . ..   |||.. . 
ddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

SQRttsKVGVKVPSQLRYIDYV
.||      |  |||.|.. ..
eqR...pgavqtpsqyrflyea
PTEN_1 40-215 2.6e-40 133.3 In-house 7-193 (196) alignment 
Range on Protein: 40-215
Range on HMM: 7-193/196.0
NNTTIRFKDGEFDLDLSYITERIIAMS-FPSEDT--VINSTWYRNSRVDVKKMLDKYHRDH-YLIINLTEKS------YDSSF-FGGRVH--HIGCVDNH
 .   .  . ...|||.|||.|||||. .||..    |  ..||.|. || ..||  . |. .|..||.|..      || .. | ..|   |..  | .
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

SPSLGLLLYAVQVIHKWLSEDP-KNVVAIHCLAGLGRSGTLIVAYLLTSLYeGRKEEALQLFASQRTTSKVGvkVPSQLRYIDYVHQLVT
 |||  |. .. ... ||..|| .|||..|| ||||||||.. |||. .      .|||.|....|.   .    ||| |.. |...|  
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella
0037934 (Phosphotyrosine protein) phosphatases II 40-211 4.3e-28 93.9 In-house 10-238 (243) alignment 
Range on Protein: 40-211
Range on HMM: 10-238/243.0
NNTTIRFK--------------DGEFDLDLSYITERIIAMSFPSEDTVIN-------STWYRNSRVDV---------------------------KKMLD
| .  |..              .. ....|.|.|.|.||...| ..|| .         |  ...| |                            ..|.
nlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtlls

KYHRDHYLIINLTEKS---YDSSFFGGRVHHIGCVDNHSPS-LGLLLYAVQVIHKWLSE-------DPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRK
 .| |.| . .|. .    .| .... ..|...  |.. |.    ||  .. ......|       |....|..|| ||.||.||||.|||. .|..   
eehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdl

EEALQLFASQRTTskVGVKVPSQLRYIDYVH
|||..|. .||    ..|  |||.|.. ...
eeavkllreqRpg..kavqtpsqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 41-215 7.9e-22 73.4 In-house 57-276 (317) alignment 
Range on Protein: 41-215
Range on HMM: 57-276/317.0
NTTIRFKDGEFDLDLSYI----------TERIIAMSFPSEDTVIN-----------------------------------STWYRNSRVDVKKMLDkyhR
.. ..... ..|||..||          . ..||...| ..|| .                                   .. | . .| ....      
hsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee...l

DHYLIINLTEKS-YDSSFFGGRVHHIGC-VDNHSP-SLGLLLYAVQVIHKWLSeDPKNVVAIHCLAGLGRSGTLIVAYLLT----SLYEGRKEEALQLFA
... . .|. .  .||  .  ...|     | . | |. |||  .. ....|. ||...|..|| ||.||.||.|.|||.       ..   |||.. . 
agitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelr

SQRttsKVGVKVPSQLRYIDYVHQLVT
.||     .|  |.|.|.. ....   
eqR...pgavqtpeqyrflydalleyl
subfamily_Tensin_pd Subfamily Tensin 45-227 2.7e-40 130.9 In-house 3-182 (189) alignment 
Range on Protein: 45-227
Range on HMM: 3-182/189.0
RFKDGEFDLDLSYITERIIAMSFPSEDTvinSTWYRNSRVDVKKMLDKYHRDHYLIINLTEKSYDSSFFGGRVHHIGCVDNHSPSLGLLLYAVQVIHKWL
|. . ..||||.||||||||.|||.| .    . ||..  || |.|.. |.|.||. ||.||.|| | .  .|  .|  |...|||  |   .. ...||
ryveekvdldltyiteriialsfpaegl...eekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWl

SEDPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKEEALQLFASQRTTSK--VGVKVPSQLRYIDYVHQLVTSQrpVDVVQNPM
..||.|||..||  | || | .. ||.  |     ...||. || .| . .  .|.  ||| ||..|. .|....  . . ..|.
kadpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk..iklnsspl
0039614 (Phosphotyrosine protein) phosphatases II 46-212 5.3e-30 100.3 In-house 76-286 (297) alignment 
Range on Protein: 46-212
Range on HMM: 76-286/297.0
FKDGEFDLDLSYI-----------TERIIAMSFPSEDTV---------------------------INSTWYRNSRvDVK----KMLDKYHRDHYLIINL
   ...|||..||           | ..||...|...||                             . |  ..    .    ..|. .|.|.| . .|
kpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtl

TEKSYDSSFFGGRVHHIGCVDNHSP-SLGLLLYAVQVIHKWLSED-PKNVVAIHCLAGLGRSGTLIVAYLLT----SLYEGRKEEALQLFASQRttsKVG
. . .. |..  .....|  |.. | || ||| ... ....|.|. ....|..|| ||.||.||.|.|||.     . ..   .||.. . .||     .
evtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR...pga

VKVPSQLRYIDYVHQ
|  |||.|.. .. .
vqtpsqyrflydall
0044763 (Phosphotyrosine protein) phosphatases II 48-217 6.1e-25 83.3 In-house 16-173 (178) alignment 
Range on Protein: 48-217
Range on HMM: 16-173/178.0
DGEFDLDLSYITERIIAMSFPSedtvinstwyrnsrVDVKKMLDKYHRDHylIINLTE---------KSYDSSFFGGRVHHIGCVDNHSPS-LGLLLYAV
 . . ...|.|.......|.|.              .| ...| ... .|  |.||||           |. . .| ...||...|.. |. |  .| .|
ersdyinaseilpglylgslpp..............addlellkelgith..ivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefv

QVIHKWLSEDPkNVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFASQRttsKvGVKVPSQLRYIDYVHQLVTSQ
. |...|.|.. ..|..|| ||.||||||..|||. .|     |||..|. ..|     .|  |.|||.. .... . ..
efieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR...p.ivpnpgqlrqLyefelrllke
0040439 (Phosphotyrosine protein) phosphatases II 48-210 2.9e-21 71.6 In-house 34-241 (249) alignment 
Range on Protein: 48-210
Range on HMM: 34-241/249.0
DGEFD--------LDLSYITERIIAMSFPSEDTV---INSTWYRNSRVDVK-----------------------------KMLDKYHRDHYLIINLTEK-
.| |.        .|..||. |.||...| ..||   ..  |  ...| |                              ..|. .. |.| . .|. . 
pglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltn

-SYDSSFFGGRVHHIGCVDNHSP-SLGLLLYAVQVIHKWLSED-PKNVVAIHCLAGLGRSGTLIVAYLLT----SLYEGRKEEALQLFASQRttsKVGVK
  ...|.    ...... | . | |.  ||  .. ..|.|.|. ....|..|| ||.||.||.|.|||.       ..   |||..|. |||     .| 
lydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR...pgavq

VPSQLRYIDYV
 |.|.|.. ..
npeqyrflyea
0041856 (Phosphotyrosine protein) phosphatases II 49-212 1.5e-28 95.0 In-house 13-168 (182) alignment 
Range on Protein: 49-212
Range on HMM: 13-168/182.0
GEFDLDLSYITERIIAMSFPSEDTVINSTWYRNSRVDVKKMLDKYhrDHYLIINLTEKSYDSSFFGG---RVHHIGCVDNHSPSlglLLYAVQVIHKWLS
 ....||.||.......|.|. . ..  .   ..  |  .|| ..  .  .|.||||  |. ...     ....... |.. |.   |  ... |...|.
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkel..gittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle

edPKNVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFASQRttsKVGVKVPSQLRYIDYVHQ
  ....|..|| ||.||.|||..|||. .| .   |||..|. |.|     .|  |.|.... ..  
..eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR...pgmvitpnqyfflqlall
0046846 (Phosphotyrosine protein) phosphatases II 49-214 2.1e-27 91.4 In-house 6-172 (176) alignment 
Range on Protein: 49-214
Range on HMM: 6-172/176.0
GEFDLDLSYITERIIAMSFPsedTVINSTWYRNSRVDVKKMLDKyhrDHYLIINLTEKS-----------YDSSFFGGRVHHIGCVDNHSPSLGLLLYAV
  .||||.||....|..|.|    .    ..|.   ... ...    ......||||              .   .| ...|.. .|.. |.| ||| ..
lgldldldyinanlilgsrp...iatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

QVIHKWLSEDpkNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKEEALQLFASQRTTskVGVKVPSQLRYIDYVHQLV
. |...|.|.  ..|..|| ||.||.|||..|||| . .    ||||.|. .||      |  |.|.|.. ....|.
efirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 51-213 5.8e-33 109.4 In-house 11-159 (172) alignment 
Range on Protein: 51-213
Range on HMM: 11-159/172.0
FDLDLSYITERIIAMSFPsedtvinstwYRNSRVDVKKMLDKYHRDHylIINLTEK---SYDSSFFGGRVHHIGCVDNHSPSLGLLLYAVQVIHKWLSED
..|||.||. |.||. .|          .||   |. .|| ... .|  |.||||     .. . .| ....... |.. |.| ||| ... |...| ..
syldlyyipdrfiatqgp..........lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellals

PKNVVAIHCLAGLGRSGTLIVAYLLTslYEGRKEEALQLFASQRttsKVGVKVPSQLRYIDYVHQL
|...|..|| ||.||.|||..|||.   .    |||..|. ..|     .|  |||.|.. | ..|
pggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekl
0045098 (Phosphotyrosine protein) phosphatases II 51-215 8e-24 79.9 In-house 5-272 (278) alignment 
Range on Protein: 51-215
Range on HMM: 5-272/278.0
FDLDLSYITERIIAMSFPSEdtvINSTWYRNSRV------------------------------------------------------------------
..|||....|.......|||   |.   |....                                                                   
asldlllefefllllgipse...itpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------DVKKMlDKYHRDHYLIINLTEKSYDSSFFGGRVHHI-GCVDNHSPSLG---LLLYAVQVIHKWLS----------
                         ... . |.|.  ..|..||| . .|   .| ...|. .  |...|||     .| ... |...|.          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--EDPKNVVAIHCLAGLGRSGTLIVAYLLTSLYeGRKEEALQLFASQRTTSKV-GVKVPSQLRYIDYVHQLVT
  .|....|..|| ||.||.|||..|||. .|. ...  .|. ..  |.      |  ..|.|.. ...... 
llldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllell
0046845 (Phosphotyrosine protein) phosphatases II 51-211 8.2e-22 73.3 In-house 68-270 (284) alignment 
Range on Protein: 51-211
Range on HMM: 68-270/284.0
FDLDLSYITERIIAMSFPSEDTV--------------------------INSTWYRNSRVDVKKM-------LDKYHRDHYLIINLTEKSYD---SSFFG
.||||.||. ..||...| ..||                          .   .|...  .|...       |.....|.| ...|. . ..    |.. 
ydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtv

GRVHHIGCVDNHSP-SLGLLLYAVQVIHKWLSE-DPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRK-------EEALQLFASQRttsKVGVKVPSQLR
   |...  |.. | |.  ||  .. ....|.. ........|| ||.||.||.|...|| ...| ..       .||.. . .||      |  ..|.|
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR...pgmvqtleqyr

YIDYVH
.. .. 
fvyeal
subfamily_Auxilin_pd Subfamily Auxilin 52-215 3.3e-39 127.3 In-house 8-165 (166) alignment 
Range on Protein: 52-215
Range on HMM: 8-165/166.0
DLDLSYITERIIAMSFPSEDtvINSTwYRNSRVDVKKMLDKYHRDHYLIINLTEKSYDSSFFGGRVHHIGCVDNHSPSLGLLLYAVQVIHKWLSEDPKNV
|||.|||| ||| ||||.|.  ..|| |.|.  ||...|.  | ..||..||....|... . .|| ..|.  .. |.|  |.   . ...|| .|||||
dlDisyitsriivmsfPaeg..vest.yknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknv

VAIHCLAGLGRSGTLIVAYLLTSLYEGRKEEALQLFASQRTTSKvgvKVPSQLRYIDYVHQLVT
| .||  |   |..|..|.|.        |.|..||. .|..       ||. ||. |. .|..
vvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladlla
0036282 (Phosphotyrosine protein) phosphatases II 52-213 3.2e-37 123.3 In-house 9-168 (174) alignment 
Range on Protein: 52-213
Range on HMM: 9-168/174.0
DLDLSYITERIIAMSFPSEdtvINSTWYRNSRVDVKKMLDKYHRDHYLIINLT-EKSYDSSFFGGRVHHIGCVDNHSPSLGLLLYAVQVIHKWLSEDPKN
.|||||||.|.||...| .       .....  .|  .|. .....|..||.. |...| . .| ........|.. |.|  || .|. ....|||||..
pldlsyitprliagqgpla...fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpgg

VVAIHCLAGLGRSGTLIVAYLLTSLYEGRKEEALQLFASQRTTSKVGVKVPSQLRYIDYVHQL
.|..|| ||.||.|||..|||.  . . . ..||.|....|.    .|  |||.|.. |...|
pvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0051082 (Phosphotyrosine protein) phosphatases II 53-209 4.2e-23 77.0 In-house 6-146 (151) alignment 
Range on Protein: 53-209
Range on HMM: 6-146/151.0
LDLSYITERIIAMSFPSEdtvinstwyrnsrvDVKKMLdkYHRDHYLIINLTEKS---YDSSFFGG---RVHHIGCVDNHSPSLGLLLYAVQVIHKWLSE
...||.|........|..              |. ..|  .. ... |.||...    |. ...     .|.|| ..|.. |.| |.. ||. ....| .
infsyvtgglyrsggpla..............dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld

DPKNVVAIHCLAGLGRSGTLIVAYLLTslYEGRKEEALQLFASQRTtskvGVKVPSQLRYIDY
.....|..|| ||.||.|||...||.   .    ||||. . ..|.    ||  |.| ... .
kkngpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp....gvvqpnqqflfql
0038934 (Phosphotyrosine protein) phosphatases II 57-216 1.5e-36 121.3 In-house 15-172 (194) alignment 
Range on Protein: 57-216
Range on HMM: 15-172/194.0
YITERIIAMSFPSEDTVIN--STWYRNSRVDVKKMLDKYHRDHYLIINLT--EKSYDSSFFGG---RVHHIGCVD-NHSPSLGLLLYAVQVIHKWLSEDP
.||.|.||...|..... .  . .||.|  |. ..|. ......|.|.||  |. || . | .   ..... ..| ...||| .||  .......|.|||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVVAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEALQLFASQRttskvgvkvPSQLRYIDYVHQLVTS
..|||.|| |||||.|||..|||. . .    |||..||.. |         |......||...|.. 
ggvvaVHCkaGlgRtGtlvaaYLiyr.lgmsaeeAialfrekR.........pgaipnqdyleallkr
subfamily_CDC14_pd Subfamily CDC14 57-184 2.2e-11 38.2 In-house 175-297 (328) alignment 
Range on Protein: 57-184
Range on HMM: 175-297/328.0
YITERIIAMSFPSEDTVINSTWYRNSRvdvKKMLdKYHRDH--YLIINLTEKSYDSSFFGG-RVHH--IGCVDNHSPSLGLLLYAVQVIHKWlsedpKNV
 . ....|.. | . . .....  ..    .|.| .| |..    .. | .| || . |    ..|  .  .|   ||  ..   .... |      .  
ivPdkflalagPhnkskledgyplhaP...ekll.eyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa

VAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEAL
.|.|| ||||| |||| .||.   |.   .||.
iavhCkaGLGrtGtLiacylmkh.yrftaaeai
0050432 (Phosphotyrosine protein) phosphatases II 59-207 2.2e-13 45.7 In-house 107-291 (308) alignment 
Range on Protein: 59-207
Range on HMM: 107-291/308.0
TERIIAMSFPSEDTVI--------------------------------------NSTWYRNSRVDVKKMLDkyhRDHYLIINLTEKS--YDSSFFGGRVH
. ..||.  | ..||                                       .|. | . .| ....     .|.| . .|. .   .. |..    |
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfh

HIGCVDNHSPS-LGLLLYAVQVIHKWLsedPKNVVAIHCLAGLGRSGTLIVAYLLTSLY-EGRKEEALQLFASQRTTSKVGVKVPSQLRYI
.... | . |. .  ||  .. ..|.|   |......|| ||.||.||.|...|| ... ....  ......  |.     |  |.|....
ytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
subfamily_DSP11_pd Subfamily DSP11 60-192 1.7e-08 28.6 In-house 18-158 (178) alignment 
Range on Protein: 60-192
Range on HMM: 18-158/178.0
ERIIAMSFPSEDTViNSTWYRNSRVDVKKMLDKYHR---DHYLIINLT--EKSYDSSFFGGR-VHH--IGCVDNHSPSLGLLLYAVQVIHKWL--SEDPK
 |.||.  | .... ..   .. |. .|..|.| .    .  |.|.||  .. |. . .  . |..  . |. .. |.  |.    ......|  ..| .
trfiafktPlkesf.dkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdnd

NVVAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEALQLFASQRT
.....||  |. |.| ||  ||.    . . |.|.. | . | 
kligvhCthGvnrtGyliCrylidv.egyepedaieafeearG
0049772 (Phosphotyrosine protein) phosphatases II 61-210 7.8e-21 70.5 In-house 85-273 (314) alignment 
Range on Protein: 61-210
Range on HMM: 85-273/314.0
RIIAMSFPSEDTVINS---------------TWYRNSRVDVK-----------------------------KMLDKY-----HrdhyliinltEKSYDSS
. ||...|.| ||..                 . .|.|. |.                              ...       .          |  || .
kfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..........eelydpe

FFGGR---VHHIGCVDNHSPSLGLLLYAVQVIHKWlseDPKNVVAIHCLAGLGRSGT-LIVAYLLTSLYEgRKEEALQLFASQRTTSKVGVKVPSQLRYI
.| ..   ...| . |.. |.|  .. ....|...   |....|..|| || ||.|| ...|||.  |     ||||. . ..|. .   . ......|.
lferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqye

DYV
 . 
fil
0048076 (Phosphotyrosine protein) phosphatases II 73-211 4e-23 77.1 In-house 6-139 (145) alignment 
Range on Protein: 73-211
Range on HMM: 6-139/145.0
VINSTWYRNSRVDVKKMLDKYHRDHYLIINLTEKSYDSSFFGGRVHHIGCVDNHSPSL-GLLLYAVQVIHKWLSEDpkNVVAIHCLAGLGRSGTLIVAYL
 |   .|..|  .....    . ......|||   .. . .| ....... |.. |.|  ||| ... |...|.|.  ..|..|| ||.||.|||..|||
eilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaayl

LTSlYEGRKEEALQLFASQRttsKVGVKVPSQLRYIDYVH
. . .    ||||.|. |||     .|  |.|||.. ...
mll.lgvsleealelvrsqr...pgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 73-209 6.6e-23 76.5 In-house 6-139 (144) alignment 
Range on Protein: 73-209
Range on HMM: 6-139/144.0
VINSTWYRNSRVDVKKMLDKYHRDHYLIINLTEKSYDSSFFGG--RVHHIGCVDNHSPSL-GLLLYAVQVIHKWLSEDpkNVVAIHCLAGLGRSGTLIVA
 | . .|..|  .....    . .....|||||. .  ..     ...|... |.. |.|  ||| ... |...|.|.  ..|..|| ||.||.|||..|
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaa

YLLTSLYeGRKEEALQLFASQRTtskVGVKVPSQLRYIDY
||.  |     ||||.|. |.|     .|  |.|||.. .
ylmkklg.lsleealalvrsrrp...gavpnpgqlrfLle
0049260 (Phosphotyrosine protein) phosphatases II 77-212 2.9e-26 87.4 In-house 16-147 (152) alignment 
Range on Protein: 77-212
Range on HMM: 16-147/152.0
TWYRNSRVDVKKMLDKYHRDHYLIINL-TEKSYDSSFFGGRVHHIGCVDNHSPSLGLLLYAVQVIHKWLSEDPKNVVAIHCLAGLGRSGTLIVAYLLTsl
 ...|.  |...|| ... .... ..  .|. ..   .. ...|. . |.. |.|  ||. .  ....| .|....|..|| ||.||.|||..|||.   
gpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..

YEGRKEEALQLFASQRttsKVGVKVPSQLRYIDYVHQ
.    |||..|. ..|   ...|  |.|||.. ....
lgvsleeavalvrekR...pgavpnpgqlrflyefek
0051299 (Phosphotyrosine protein) phosphatases II 79-209 6.6e-17 57.3 In-house 61-280 (288) alignment 
Range on Protein: 79-209
Range on HMM: 61-280/288.0
YRNSRVDVK----------------------------------------------------------------------------------KMLDKYHRD
| .||| ..                                                                                  ..|. .. |
ydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevld

HYLIINLTEK------SYDSSFFGGRVHHIGCVDNHSPS-LGLLLYAVQVIHKWLSeDPKNVVAIHCLAGLGRSGTLIVAYLLTSL-YEGRKEEALQLFA
.| . .|. .        . |..    |...  |.. |. . |||  .. ..|.|. .....|..|| ||.||.||.|...|| ..  .... ..|....
dytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavk

SQRTTSKVGVKVPSQLRYIDY
  |.     |  |.|.|.. .
rlreqRpgmvqtpeqyrfvye
subfamily_DSP8_pd Subfamily DSP8 79-204 3.5e-07 23.9 In-house 23-147 (159) alignment 
Range on Protein: 79-204
Range on HMM: 23-147/159.0
YRNSRVDV--KKMLDKYHRDHYLIINLTEKSYDsSFFGGRVHHIGCVDNHSPSL-GLLLYAVQVIHKWLSEDPKnvVAIHCLAGLGRSGTLIVAYLLTSL
|  |..||  ...|.|.  .. |... .  . .  .   .....   |...  |   .  .|. | |  ||. .  | .|.|||  || |...||..  |
ylGsqkdvlseellsklgisyvlnasnscpkle.elkeskflrvPvkDkydekllpwfdksvefidkaksengr..vlvhvlaGisrsatvaiayimktl

yEGRKEEALQLFASQRTTSKVGVKVPSQL
 |   .|| .   ..|.| .  .    ||
.emsldeayrfvkekrptispnlnflgqL
0036941 (Phosphotyrosine protein) phosphatases II 81-211 3.3e-14 48.3 In-house 136-273 (297) alignment 
Range on Protein: 81-211
Range on HMM: 136-273/297.0
NSRVDVKKMLDKyHRDHYLIINLTEK--SYDSSFFGGRVHHIGCVDNHSPS-LGLLLYAVQVIHKWLSED-PKNVVAIHCLAGLGRSGTLIVAYLLTSLY
. .| ....  . . |.| . .|. .   .. |..    |..|  |.. |.    ||  .. ..|.|..  ....| .|| ||.|||||.|.|.|. ...
dftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

EG----RKEEALQLFASQRTTSKVGVKVPSQLRYIDYVH
|.    ..   |... . |.     |  ..|.|.. .. 
edklkeggvdileavkklReqRpgavqtleqyrflyeal
0047943 (Phosphotyrosine protein) phosphatases II 88-210 3.5e-19 64.8 In-house 140-267 (273) alignment 
Range on Protein: 88-210
Range on HMM: 140-267/273.0
KMLDKYHRDHYLIINLTEKS--YDSSFFGGRVHHIGCVDNHSP-SLGLLLYAVQVIHKWLSED-PKNVVAIHCLAGLGRSGTLIVAYLLTSLY-EGRKEE
..|. ...|.| . .|. ..  .. |..   .|. |  |.. | ||  ||  .....|.|...  ...|..|| ||.||.||.|...|| ... ....  
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ALQLFASQRTTSKVGVKVPSQLRYIDYV
.|....  |.    .|  |.|.|.. ..
vleavkllrsqRpgmvqtpeqyrflyea
subfamily_RNGTT_pd Subfamily RNGTT 96-192 4.1e-11 36.9 In-house 54-155 (189) alignment 
Range on Protein: 96-192
Range on HMM: 54-155/189.0
DHYLIINLTE--KSYDSSFF---GGRVHHIGCVDN-HSPSLGLLLYAVQVIHKWLSEDPKNVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFAS
   |.|.||.  . || . .   | . ... |  . ..|.        ...... .. |..|...||  |  |.| |||.||.    .   |.|..|||.
klglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLveke.dwsveaavalFak

QRT
 | 
aRp
subfamily_PRL_pd Subfamily PRL 96-193 6.4e-10 33.3 In-house 34-132 (151) alignment 
Range on Protein: 96-193
Range on HMM: 34-132/151.0
DHYLIINLTEKSYDSSFFG---GRVHHIGCVDNHSPSLGLLLYAVQVIHKWLSEDPKNVVAIHCLAGLGRSGTLIVAYLLTSlyeG-RKEEALQLFASQR
.   ..   | .||.. .     .|. .   |  .|.  ..   ......  .|.||..||.||.|||||.  |..  |. .   | ..|.|...  ..|
evktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea...Gmkyedavefirekr

TT
  
rg
0051429 (Phosphotyrosine protein) phosphatases II 98-194 5.7e-10 34.8 In-house 47-207 (272) alignment 
Range on Protein: 98-194
Range on HMM: 47-207/272.0
YLIINLTEKSYDSSF------FGGRVHHIGCVDNHSPSL----------------------------------------------------GLLLYAVQV
  |..|.. ..  ..       | |..|. ..|.. |.                                                       || ....
ktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellel

IHKwlsedpKNVVAIHCLAGLGRSGTLIVAYLLTslYEGR--------------KEEALQLFASQRTTS
...      .. | .|| || .|.||.....||   .                  |||..   .||  .
lld......ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeaveelraqrpga
subfamily_DSP14_pd Subfamily DSP14 99-191 8e-06 19.9 In-house 34-124 (157) alignment 
Range on Protein: 99-191
Range on HMM: 34-124/157.0
LIINLTEKSYDSSFFGGRVHHIGCVDNHSPSLGLLLYAV-QVIHKWlSEDPkNVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFASQR
||||.| .  . .. . .. ..   ||.. .|   .  | . |..  ...    . .|| ||  || .| .|||.    .   .|| .|  |.|
liinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieev.kkkg.gktlvhCvaGvSRSAslclaylmkye.klsLreayklvksaR
subfamily_DSP23_pd Subfamily DSP23 101-173 4.4e-07 24.7 In-house 36-108 (148) alignment 
Range on Protein: 101-173
Range on HMM: 36-108/148.0
INLTEKSYD--SSFFGGRVHHIGCVDNHSPSLGLLLYAVQVIHKwlSEDPKNVVAIHCLAGLGRSGTLIVAYLLT
. |||..     .  .  .....  | | |.|  .   |.|...  .|. .. |..||| | ||.||..  ||. 
vslteegrphveatpnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvk
0048567 (Phosphotyrosine protein) phosphatases II 105-198 1.3e-07 26.2 In-house 25-125 (157) alignment 
Range on Protein: 105-198
Range on HMM: 25-125/157.0
EKSYDSSFF---GGRVHHIGCVDNHSPSLGLLLYAVQVIHKWLS--EDPKNVVAIHCLAGL---GRSGTLIVAYLLTSLYEgRKEEALQLFASQRTTSKV
.. |.  .|    | |..  . |.  ..|..|   .....|.|.  |  ....|.|| |||   ||..||| .||.  |     |||.....  | .|..
kslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf.tpeeaiaplrivrpgsvp

GV
. 
fr
subfamily_PTPMT1_pd Subfamily PTPMT1 114-195 1.9e-09 32.2 In-house 73-152 (171) alignment 
Range on Protein: 114-195
Range on HMM: 73-152/171.0
GGRVHHIGCVDNH-SPSLGLLLYAVQVIHKWLSEdpKNVVAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEALQLFASQRTTSK
|    ..  ||   .|.|  |. .|..|.|  |.  .. | .|| || |||.||. .||... ..   ||||.  ...| . .
gveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkk.eklspeeAlkalkkkRkiir
subfamily_DSP6_pd Subfamily DSP6 116-175 5.8e-07 23.2 In-house 61-119 (158) alignment 
Range on Protein: 116-175
Range on HMM: 61-119/158.0
RVHHIGCVDNHSPSLGLLL-YAVQVIHKWLSEDpkNVVAIHCLAGLGRSGTLIVAYLLTSL
.  .|   |..|  |  ..  |.. | .  |..  . | .|||||. || |...|||. .|
kylqipiedhlsqnlakffPeaiefidearskk..skvlvhClaGisrsvtvtlaylmkkl
subfamily_PTPDC1_pd Subfamily PTPDC1 117-213 6.5e-11 37.0 In-house 85-174 (182) alignment 
Range on Protein: 117-213
Range on HMM: 85-174/182.0
VHHIGCVDNHSPSLGLLLYAVQVIHKWLSEDpknVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFASQRTTSkvgVKVPSQLRYIDYVHQL
|. .|  |  ..||  .|  |.|..  |.|.    ||.|| ||||| | || .||. .  .   |.|..|  |.|. |   ..  .|.. .   ...
vynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak.rltaekaiklvrskrpks...iqtreqvelvkefalf
PTPc_DSPc_SM00012 117-208 6.3e-10 34.6 In-house 5-100 (105) alignment 
Range on Protein: 117-208
Range on HMM: 5-100/105.0
VHHIGCVDNHSPS-LGLLLYAVQVIHKWLSEDP-KNVVAIHCLAGLGRSGTLIVAYLLTSLYEGR--KEEALQLFASQRTTSKVGVKVPSQLRYID
.|. |. | . |.    .| ... ..|. ..   .. | .|| || ||.||......| .  | .  . . .|.. . |.     |.   |  .. 
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly
subfamily_DSP19_pd Subfamily DSP19 119-193 5.6e-08 27.3 In-house 60-132 (152) alignment 
Range on Protein: 119-193
Range on HMM: 60-132/152.0
HIGCVDNHSPSLG-LLLYAVQVIHKWLSEDpkNVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFASQRTT
.| ..|.   .|   | .|.. |.. .|.|  ..| .|| ||  || ....|||...  | . ||||.|  ..| .
sieilDlpetdllsylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkke.elsleealelvrearpc
subfamily_DSP12_pd Subfamily DSP12 120-204 1.3e-07 26.2 In-house 54-136 (155) alignment 
Range on Protein: 120-204
Range on HMM: 54-136/155.0
IGCVDNHS-PSLGLLLYAVQVIHKWLSEdpKNVVAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEALQLFASQRTTSKVGVKVPSQL
| ..|. . . |  |  ||. |.. |.|  .. | .|| ||. || |...|||. . ..   |.||.|  ... . .      .||
iqilDepeediLshldeavdFieealee..egavlvHCqagvSRSvtiviAYlmkk.eklslekAlklvkekkpeiepNegFleQL
PTPc_motif_SM00404 127-191 2.2e-09 32.3 In-house 60-121 (140) alignment 
Range on Protein: 127-191
Range on HMM: 60-121/140.0
SPSLGLLLYAVQVIHKWlsEDPKNVVAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEALQLFASQR
.. .  |  ....|..   |. .  | .|| ||. ||.|||.|||... ..   .||.... ..|
dklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmry.rqlslaeayefvkerR
DSPc Dual specificity phosphatase, catalytic domain 130-197 1.6e-10 36.0 Pfam-A 56-120 (133) alignment 
Range on Protein: 130-197
Range on HMM: 56-120/133.0
LGLLLYAVQVIHKWlsEDPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEgRKEEALQLFASQRTTSKVG
   |  ||..|.|   |. .. |..|| ||. ||.|||.|||...    . .||.... ..| .    
skeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskispn
DSPc Dual specificity phosphatase, catalytic domain 130-197 1.6e-10 36.0 In-house 56-120 (133) alignment 
Range on Protein: 130-197
Range on HMM: 56-120/133.0
LGLLLYAVQVIHKWlsEDPKNVVAIHCLAGLGRSGTLIVAYLLTSLYEgRKEEALQLFASQRTTSKVG
   |  ||..|.|   |. .. |..|| ||. ||.|||.|||...    . .||.... ..| .    
skeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskispn
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 132-207 2.5e-06 21.7 In-house 179-256 (270) alignment 
Range on Protein: 132-207
Range on HMM: 179-256/270.0
LLLYAVQVIHKWLSEDPKN-VVAIHCLAGLGRSGTLIVA-YLLTSLYEGRKEEALQLFASQRTTSKVGVKVPSQLRYI
 ||. .. .... .|  |.  . .|| ||.||.||||.  . .  | | .| . |.. .  |      |. | | ...
qllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_DSP15_pd Subfamily DSP15 135-205 2.2e-09 31.6 In-house 66-133 (151) alignment 
Range on Protein: 135-205
Range on HMM: 66-133/151.0
YAVQVIHKWLSEDpkNVVAIHCLAGLGRSGTLIVAYLLTSLyEGRKEEALQLFASQRTTSKVGVKVPSQLR
 .|..|||  ...  . | .|||||. || ||.||||.| . |   ..||.    .|....  .   .||.
esvefihkcRlke..envlvhClaGvsRsvtlvvaYlmtvt.elnwrdalevikaaRsvanPnfGfkrqlk
subfamily_DSP3_pd Subfamily DSP3 135-175 1.8e-06 21.7 In-house 84-123 (162) alignment 
Range on Protein: 135-175
Range on HMM: 84-123/162.0
YAVQVIHKWLSEdPKNVVAIHCLAGLGRSGTLIVAYLLTSL
 |.. |.. ||. ..  | .|| .|. || ||..|||. . 
taakfidealsq.kegkvlvhcvvGvsRsatlvlayLmirr
subfamily_DSP1_pd Subfamily DSP1 149-204 3e-06 21.4 In-house 95-149 (163) alignment 
Range on Protein: 149-204
Range on HMM: 95-149/163.0
KNVVAIHCLAGLGRSGTLIVAYLLTSlYEGRKEEALQLFASQRTTSKVGVKVPSQL
.  | ||| ||. || ||..|||...  . . ||| ..  ..|. ..  .    ||
nGkvlihCqaGisRsstlclaylmkt.krvsleeafdfvkqrRsiisPnagFvlqL
subfamily_DSP10_pd Subfamily DSP10 149-190 4.9e-06 20.5 In-house 92-132 (159) alignment 
Range on Protein: 149-190
Range on HMM: 92-132/159.0
KNVVAIHCLAGLGRSGTLIVAYLLTSLYEgRKEEALQLFASQ
 . | .|| ||. || |...|||.. |     ..| ..  ..
gsrvLvhCqaGisrsatvviaYlmkhlnl.slndaykfvkek
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 225-377 5e-24 76.0 Pfam-A 2-133 (134) alignment 
Range on Protein: 225-377
Range on HMM: 2-133/134.0
NPMKLRLNAIMIKPSPVVsgKSGQVWKPTIEIFNVMKPLEphllfstkDLDGPFNKNQNDafckVQGDVVIIETQSLVLQGDVLVKIYHGFSDILSKEVl
|| .|.|..|.... | .  |... .|| ....| .|..         . .. .......     . .... | ..|...|||||...|  |.. .||  
npkrlelksiilegiPnf..ktrggckpkvkvyngkkkvf........kelasykdster....raktfivkepnrlpveGDvlveflhkdsklpkkek.

nvimdkpSLRLAFHTSFID--NHCLDLNRSTLDEKDNCIqSDKFSQDFSLRLLFS
        .|..|.||||.  ...| |... ||. ..   ..|||..|...|.|.
.......ifrvwFNTsFieknqnvltlpkneLDkalkdk.dkkfsknfkvelvfe