Gene DDB_G0292920 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP043_AA protein Get Run
DdisP043_AA_6-199 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 7-199 4.8e-29 97.2 In-house 48-290 (297) alignment 
Range on Protein: 7-199
Range on HMM: 48-290/297.0
FDYFRTIVSGRKKRFI--------------QDGFNLDLSYI-----------TERILAMGYPADS-----IHKAFRNDINEVY-----------------
. ... .... | |..               ||..||..||           | ...|...| ..     ..  ...... .                  
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywp

-----------NFFEKYHSAHWKILNVAMEIsYSTTKVGGNVIVMGFEDHTPPP-FLLLLDIIETMNKWLDSD-EQNVIAVHCKAGKGRTGTVISSYLIN
           .. . .| ..... .  ..  .. ..    . ..|. ||..|| . |||...| ....| .. ......|||.||.|||||.|  ||. 
eeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylml

QMKRTTPDLFyssdtiLYNTISFFNQMRannSECVTVPSQKRYVGYYIQYLRD
.. ... ..       ...........|   . .|. ||| |.. .....|. 
eqlekeggvd......vleavkelreqR...pgavqtpsqyrflydallellk
0042113 (Phosphotyrosine protein) phosphatases II 8-197 6e-26 86.8 In-house 2-242 (245) alignment 
Range on Protein: 8-197
Range on HMM: 2-242/245.0
DYFRTIVSGRKKRF-------------IQDGFNLDLSYI----------TERILAMGYPADSIHK-----AFRNDINEVY--------------------
.... .... | |.               ||..||..||          |....|...|...  .      ....|. .                     
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

----------NFFEKYHSAHWKILNVAMEI-SYSTTKVGGNVIVMGFEDHTPPP-FLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQ
          .. . .| ..... .. ..   .. .. . ..  ....||..|.   ||||..| ..|.| .|......|||.||.|||||.|  ||. .
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

MKRTTPDLFyssdtiLYNTISFFNQMRannSECVTVPSQKRYVGYYIQYL
. ... ..       |.... .....|   . .|. ||| |.. .....|
qlekelgvs......leeavkelrsqR...pgavqtpsqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 9-197 7.6e-25 83.7 In-house 49-303 (307) alignment 
Range on Protein: 9-197
Range on HMM: 49-303/307.0
YFRTIVSGRKKRFIQ-------------------------------------DGFNLDLSYI----------------------------------TERI
...  ... | |.                                       ||..|.. .|                                  . ..
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

LAMGYPADSIHKAFRNdinEVYNFFEKYHSAHWKILNVAMEIsYSTTKVGGNVIVMGF---EDHTPPP-FLLLLDIIETMNKWLDSD-EQNVIAVHCKAG
 |. .| .. .. ..|    . .. ...| ........ ..  .. |. .  |... .    ||. || |  |||.|| ..|.|... ......|||.||
caqywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

KGRTGTVISSYLINQMKRTTPDLFYSSdtiLYNTISFFNQMRannSECVTVPSQKRYVGYYIQYL
.|||||.|  ||. .. .... |.. .   |....... ..|   . .|. |.| |.. .....|
vgRtGtfiaaylmlrqlekegtlldvd...lleavkllreqR...pgavqnpeqyrflyeallel
0044763 (Phosphotyrosine protein) phosphatases II 9-198 6.5e-23 76.7 In-house 2-171 (178) alignment 
Range on Protein: 9-198
Range on HMM: 2-171/178.0
YFRTIVSGRKKRFIQDGFNLDLSYITERILAMGYPAdsihkafrndiNEVYNFFEKYHSAHwkILNVAME--------ISYSTTKVGGNVIVMGFEDHTP
. ||.|.  . . .. ......|.|.........|.            . .... ...  |  |.|.. |        . |  .. | ... ....||..
ldrtrvllsnleglersdyinaseilpglylgslpp...........addlellkelgith..ivnlteelelgflkcdpywpeeagiqylhipipDhgv

PP-FLLLLDIIETMNKWLDsDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDlfyssdtilyntisFFNQMRANNSeCVTVPSQKRYVGYYIQYLR
|. .  .|...| ....|| .......|||.||.||.||..  ||. ... . ..               ....|.  . .|. |.| |.. .. ..|.
pdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkklglslee..............aielvrerRp.ivpnpgqlrqLyefelrll
subfamily_PTEN_pd Subfamily PTEN 10-200 1.4e-75 248.3 In-house 2-182 (184) alignment 
Range on Protein: 10-200
Range on HMM: 2-182/184.0
FRTIVSGRKKRFIQDGFNLDLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDI
.|.||| .|||| .||..||||||||.|.||||||.......||....|..|.||.|. |.||.|...| .|...|. |.|.|..|.||.|||. || .|
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

IETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDlfyssdtilyNTISFFNQMRANNSECVTVPSQKRYVGYYIQYLRDQ
.|...|||..|..||..|||||||||||..|..||..... ....          .....|...|..|...||.|||.||| || ..|...
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae..........ealelfaeaRtknkkgvtiPsqrRYveYyeklleee
subfamily_VSP_pd Subfamily VSP 10-196 1.2e-46 153.3 In-house 16-197 (212) alignment 
Range on Protein: 10-196
Range on HMM: 16-197/212.0
FRTIVSGRKKRFIQDGFNLDLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDI
 | .||  |.|. ||||.|||.|.||||.|| .|.   .. .|| |.||  |... |. |.|..|.  | .|  .    .|. .  .||  | .  || .
arrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvf

IETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTpdlfySSDTILYNTISFFNQMRANNSECVTVPSQKRYVGYYIQY
 .....||. |..||.|.||| |||||||.. ..|..    .|     . ... | .    .. .... . |  |||||||||. | 
tkevkewlekdlknvlaihckGGkgrtGtivcalllaseifet.....akesldyfgerrtdktegekfqGvqtpsqkryvgyleqv
0037934 (Phosphotyrosine protein) phosphatases II 10-197 1.8e-27 91.9 In-house 5-241 (243) alignment 
Range on Protein: 10-197
Range on HMM: 5-241/243.0
FRTIVSGRKKRFI--------------QDGFNLDLSYITERILAMGYPADSIHKA---------FRNDINEVY---------------------------
.. ...  | |.                | .|..|.|.|.|. |...| .. ..          ....|. .                            
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-NFFEKYHSAHWKILNVAMEI--SYSTTKVGGNVIVMGFEDHTPPP-FLLLLDIIETMNKWLDS-------DEQNVIAVHCKAGKGRTGTVISSYLINQM
 .. . .| ..... .. .|    .  |. . ..  ... ||..|. .  |||... .......       |......|||.||.|||||.|  ||. ..
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

K-RTtpdlfyssdtiLYNTISFFNQMRANnsECVTVPSQKRYVGYYIQYL
   .           |.... .. ..| .   .|. ||| |.. .....|
lgvd...........leeavkllreqRpg..kavqtpsqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 11-198 1.9e-23 78.6 In-house 39-276 (317) alignment 
Range on Protein: 11-198
Range on HMM: 39-276/317.0
RTIVSGRKKRF-------------IQDGFNLDLSYI----------TERILAMGYPADS-----IHKAFRNDINEVYNFFEKY-----------------
.  ... | |.               .|. ||..||          . ...|...| ..     ..  ...... . .. |                   
elpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetl

-------------HSAHWKILNVAMEISYSTTKVGGNVIVMGF-EDHTPPP-FLLLLDIIETMNKWLDsDEQNVIAVHCKAGKGRTGTVISSYLINQMKR
             . |....... .| ... ...  ... . .  ||..|| . ||||..| ....|. |......|||.||.|||||.|  ||. .. .
tygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqle

TTPDLFyssdtiLYNTISFFNQMRannSECVTVPSQKRYVGYYIQYLR
.. ..       ..... .....|   . .|. |.| |.. ...... 
keggvd......veeavkelreqR...pgavqtpeqyrflydalleyl
PTEN_1 12-197 2.5e-33 110.6 In-house 4-192 (196) alignment 
Range on Protein: 12-197
Range on HMM: 4-192/196.0
TIVSGRKKRFIQDGFNLDLSYITERILAMG-YPADS-----IHKAFRNDINEVYNFFEKYHSAH-WKILNVAMEIS-----YST---TKVGGNVIVMGFE
   . .||. ..... |||.|||.||.|||  |...     ... .|. . .| ....  .. .   ..|.. |       |.     | | ... ...|
lskrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpie

DHTPPPFLLLLDIIETMNKWLDSDE-QNVIAVHCKAGKGRTGTVISSYLINQMKrTTPDlfyssdtilyNTISFFNQMR-ANNSEcvtVPSQKRYVGYYI
||..|..  |.||.. .  || ||. .||..||||||.||.|||. .||.  .|  |.|          .........| ... .    |||.|.. |. 
DhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltad..........eAlelvrekRppgapn...spsqerlleyfa

QYL
. |
ell
0040439 (Phosphotyrosine protein) phosphatases II 14-197 2e-23 78.7 In-house 30-245 (249) alignment 
Range on Protein: 14-197
Range on HMM: 30-245/249.0
VSGRKKRFIQDGFN---LDLSYITERILAMGYPADSIHKAFRNDINE-----------------------------------VYNFFEKYHSAHWKILNV
.|  ...|  |  |   .|..||. |..|...| ..  ..|.. . |                                   . .... ........ ..
lsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtl

AMEISYSTTKVGGNVIVM-GFEDHTPP-PFLLLLDIIETMNKWLDSD-EQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFyssdtiLYNTISFFNQ
 .. .|  ...  ..| . .. ||  |  |  |||.|| ..|.|... ......|||.||.|||||.|  ||. .. ... ..       |.........
eltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd......leeavkllrs

MRANnseCVTVPSQKRYVGYYIQYL
.| .   .|. |.| |.. .....|
qRpg...avqnpeqyrflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 17-196 1.2e-27 92.1 In-house 6-169 (182) alignment 
Range on Protein: 17-196
Range on HMM: 6-169/182.0
RKKRFIQDGFNLDLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWK-ILNVAmEISYSTTKVGG---NVIVMGFEDHTPPPFLLLLDIIET
| . ..   ...||.||.........||. .. . .. ...|..|.. ... ... |.|.. |  |  ...     ... ....||..|..  |||.||.
rysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfiee

MNKwldsdEQNVIAVHCKAGKGRTGTVISSYLINQMKRTtpdlfyssdtiLYNTISFFNQMRANnseCVTVPSQKRYVGYYIQY
...     |.....|||.||.|||||..  ||. ... .           |..........| .   .|. |.| ... ... .
vle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvs...........leeavklvrsrRpg...mvitpnqyfflqlalle
0043336 (Phosphotyrosine protein) phosphatases II 18-197 2.2e-25 85.1 In-house 48-276 (278) alignment 
Range on Protein: 18-197
Range on HMM: 48-276/278.0
KKRF-------------IQDGFNLDLSYI----------TERILAMGYPADSIHKAFRNDINE----------------------------------VYN
| |.               .|. ||..||          .....|...| ..  . |.. . |                                  . .
knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvt

FFEKYHSAHWKILNVAMEI-SYSTTKVGGNVIVMGFEDHTPP-PFLLLLDIIETMNKWLDsDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFys
. . .| ..... .  ..   .. .. .  .  .|. ||. | .. ||||........|. |......|||.||.|||||.|  ||. .. ...  .   
llkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvd..

sdtiLYNTISFFNQMRannSECVTVPSQKRYVGYYIQYL
    |..........|     .|. ||| |.. ......
....leeavkelreqR...pgavqtpsqyrflyealley
subfamily_Tensin_pd Subfamily Tensin 19-202 3.2e-38 124.1 In-house 2-176 (189) alignment 
Range on Protein: 19-202
Range on HMM: 2-176/189.0
KRFIQDGFNLDLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAmEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWLD
.|.... ..|||.||||||.|. .||.. ....|.....| ..... |. .. ..|.. | .|  .|.  .|. .|. |.. |..  |  |......||.
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnls.ekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

SDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDlfysSDTILYNTISFFNqmraNNSECVTVPSQKRYVGYYIQYLRDQVT
.| |||..|||| ||||.| |.|.|.  .   .. |    .. . .    |..    . .. .| |||.||| |. ..| ... 
adpqnvvvvhckGgkgrigvvvsaymkyskisasad....aaldrfamkrfld....dklsgetqPsqrryveyfsglLsgkik
0046846 (Phosphotyrosine protein) phosphatases II 20-199 4.5e-27 90.3 In-house 2-174 (176) alignment 
Range on Protein: 20-199
Range on HMM: 2-174/176.0
RFIQDGFNLDLSYITERILAMGYP-----------ADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAMEisysTTKVGGNVIVMGFEDHTPPPFLLLLD
|. ..|..|||.||.........|           || ..  ....|. | |. | .. ...|. |   |     .|.|  .......||..|.. |||.
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

IIETMNKWLDSDeqNVIAVHCKAGKGRTGTVISSYLINQmkrttpdlfyssdTILYNTISFFNQMRANNS-ECVTVPSQKRYVGYYIQYLRD
..| ....|...  ....|||.||.|||||..  ||.                  ..    . ..|.  .  .|. |.| |.. .....|..
llefirealkeg..gpvlVHCsaGigRtgtlvaayllel.............ekglsveealalvreqRplgavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 23-197 2.9e-27 90.9 In-house 8-160 (172) alignment 
Range on Protein: 23-197
Range on HMM: 8-160/172.0
QDGFNLDLSYITERILAMGYPadsihkaFRNDINEVYNFFEKYHSAHwkILNVAmEI---SYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWLDS
 . ..|||.||. |..|. .|       .||......... ...  |  |.|.  |     .  .. |  .. ....||..|.. |||...| ....|  
inasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellal

DEQNVIAVHCKAGKGRTGTVISSYLINqmKRTtpdlfyssdtilyNTISFFNQMRANNSECVTVPSQKRYVGYYIQYL
.......|||.||.|||||..  ||.   ..              .    ....|.  . .|. ||| |.. |. ..|
spggpvlVHCsaGvgRtgtlvaaylml..lgl.............sleeavalvrekRpgavqnpsqyrflyyfekll
0046845 (Phosphotyrosine protein) phosphatases II 24-197 9e-22 73.2 In-house 66-273 (284) alignment 
Range on Protein: 24-197
Range on HMM: 66-273/284.0
DGFNLDLSYITERILAMGYPADS-----------------------------IHKAFRNDINEVYNF-------FEKYHSAHWKILNVAMEIS--YSTTK
||..|||.||. ...|. .| ..                              .  ......||...        ....  .... .. ..     . ..
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

VGGNVIVMGFEDHTPPP-FLLLLDIIETMNKWLDS-DEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFYSSdtiLYNTISFFNQMRANnseCVTV
      .... ||  || .  ||.........|.. . ...|.|||.||.|||||.|  .|. .. ... .|.  .   ........ ..| .   .|. 
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd...vleavkrlreqRpg...mvqt

PSQKRYVGYYIQYL
..| |.| ......
leqyrfvyealley
0045098 (Phosphotyrosine protein) phosphatases II 25-198 3.6e-24 81.1 In-house 4-272 (278) alignment 
Range on Protein: 25-198
Range on HMM: 4-272/278.0
GFNLDLSYITERILAMGYPADSIHKAFRNDIN--------------------------------------------------------------------
...|||....|..|..|.| .  .  ......                                                                    
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------EVYNFfEKYHSAHWKILNVAMEISYSTtKVGGNVIVM-GFEDHTPPPFL---LLLDIIETMNKWLD-----------
                       ..... ..|.  .... |. .| .. . . | ... . ...||..|..     .|...| ....|.           
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

-SDEQNVIAVHCKAGKGRTGTVISSYLINQM---KRTtpdlfyssdtiLYNTISFFNQMRanNSECVTVPSQKRYVGYYIQYLR
  |......|||.||.|||||..  ||. ..   . .           |....... ..|  . ..|. ..| |.. .....|.
lldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd...........lleavkelrsqR..pglavqnleqyrflyefllell
0036282 (Phosphotyrosine protein) phosphatases II 26-197 3.7e-35 116.5 In-house 8-169 (174) alignment 
Range on Protein: 26-197
Range on HMM: 8-169/174.0
FNLDLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVI
..|||||||.|..|...|.. ..  ....|. | .. | ..  ..|. |   | ... .. | ... ....||..|..  ||.... ....| .|.....
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AVHCKAGKGRTGTVISSYLINQMKR-TTPDLfyssdtilyntISFFNQMRANNSECVTVPSQKRYVGYYIQYL
.|||.||.|||||..  ||. .... .. |            .... ..|  .. .|. ||| |.. |. ..|
lVHCsaGvgRtGtlvaaylmlrglleslvda...........ldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_Auxilin_pd Subfamily Auxilin 27-198 2.2e-31 101.8 In-house 8-165 (166) alignment 
Range on Protein: 27-198
Range on HMM: 8-165/166.0
NLDLSYITERILAMGYPADSIHKAFRNDINEVYNFFEKYHSAHWKILNVAMEiSYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIA
.||.|||| ||. | .||. .. ...|.|..| .| |  |. .... |.. . .| |.|. . |. .|.  .  |.   |...   . .||  |..||. 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqr.tyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

VHCKAGKGRTGTVISSYLINQmkrttpDLFYSSDtilyNTISFFNQMRANNSecvTVPSQKRYVGYYIQYLR
|||| |.  .....|..|.        .|. ...    .....|.  |   .     ||.|||. |  . |.
vhckDGraasavlvsallvfc......rllsepe....savrlfsvkrlpig...lspsekryleyladlla
0051082 (Phosphotyrosine protein) phosphatases II 28-192 1.5e-19 65.5 In-house 6-146 (151) alignment 
Range on Protein: 28-192
Range on HMM: 6-146/151.0
LDLSYITERILAMGYPADsihkafrndinEVYNFFEKYHSAHWKILNVAMEISYSTTKVGG---NVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNV
...||.|......|.| .           ..........  .   |.  .|. | .  .     .|. . ..|...|.. |..|..  . ..|.......
infsyvtgglyrsggpla...........dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngp

IAVHCKAGKGRTGTVISSYLINQMkrttpdlfyssdtilYNTISFFNQMRANNSeCVTVPSQKRYVGY
..|||.||||||||..  ||. ..               ..  . ....|. .   |. |.| ... .
vlvHCsaGkgRTGtlvalylmllg...............vsleealeeyrlkrp.gvvqpnqqflfql
subfamily_CDC14_pd Subfamily CDC14 30-153 7.2e-11 36.5 In-house 172-294 (328) alignment 
Range on Protein: 30-153
Range on HMM: 172-294/328.0
LSYI-TERILAMGYPADSI--HKAF-RNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWldsdeQNVI
...|  ...||.  | .    ....  .  ......| |..  .   ||  .    . |. | .   . |.| . |.  ..   .| ..|      .  |
fnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGai

AVHCKAGKGRTGTVISSYLINQMKRTTP
||||||| |||||.|..||... . |..
avhCkaGLGrtGtLiacylmkhyrftaa
0038934 (Phosphotyrosine protein) phosphatases II 32-151 1.8e-26 88.4 In-house 15-144 (194) alignment 
Range on Protein: 32-151
Range on HMM: 15-144/194.0
YITERILAMGYPADS-----IHKAFRNDINEVYNFFEKYHSAHWKILNVAM-EISYSTTKVGG---NVIVMGFEDH-TPPPFLLLLDIIETMNKWLDSDE
.||.|..|...|...     |.   |.... . .... ..  .......   |  |..... .    .. . |.|. |.|.. .||.... ....|. |.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

QNVIAVHCKAGKGRTGTVISSYLINQMKRT
..|.|||||||.|||||.. .|||  .. .
ggvvaVHCkaGlgRtGtlvaaYLiyrlgms
subfamily_PTPDC1_pd Subfamily PTPDC1 32-149 1.3e-12 42.6 In-house 17-141 (182) alignment 
Range on Protein: 32-149
Range on HMM: 17-141/182.0
YITERILAMGYPADS-------IHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGN---VIVMGFEDHTPPPFLLLLDIIETMNKWLDSDe
..|| |||.  |  .       ..|   . |. | |. ||   |.    .     ||.. ..  .   |  .|..|.  ..   .|||.  ..  |. . 
WvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg.

qnVIAVHCKAGKGRTGTVISSYLINQMK
   .|||| ||.|||| .|..||. . .
..kvavhChaGlGrtGvliacylvyakr
0049260 (Phosphotyrosine protein) phosphatases II 47-197 2e-23 78.2 In-house 14-149 (152) alignment 
Range on Protein: 47-197
Range on HMM: 14-149/152.0
IHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGGNVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLIN
 .   .|......... ...  .   |.  .|. .  .. . ... . ..||..|..  ||...  . ..|  |......|||.||.|||||..  ||. 
tqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

qmKRttpdlfyssdtilYNTISFFNQMRANNSECVTVPSQKRYVGYYIQYL
  ..             ..   .....|. ..  |. |.| |.. .. ..|
..lg.............vsleeavalvrekRpgavpnpgqlrflyefekll
0048076 (Phosphotyrosine protein) phosphatases II 47-197 6.8e-20 66.7 In-house 8-142 (145) alignment 
Range on Protein: 47-197
Range on HMM: 8-142/145.0
IHKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTtKVGGNVIVMGFEDHTPPPF-LLLLDIIETMNKWLDSDeqNVIAVHCKAGKGRTGTVISSYLI
... .....  .... .  .  .. .||...|... . . | ... ....||..|..  |||...| ....|...  ....|||.||.|||||..  ||.
lpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylm

NQmkrttpdlfyssdtILYNTISFFNQMRANNSECVTVPSQKRYVGYYIQYL
 .                ..  . ....|.  . .|. |.| |.. .....|
ll..............lgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 48-190 1.1e-18 62.8 In-house 9-137 (144) alignment 
Range on Protein: 48-190
Range on HMM: 9-137/144.0
HKAFRNDINEVYNFFEKYHSAHWKILNVAMEISYSTTKVGG-NVIVMGFEDHTPPPF-LLLLDIIETMNKWLDSDeqNVIAVHCKAGKGRTGTVISSYLI
 . .....  .... .  .  .. ..|.. |  .   .. | ... ....|| .|..  |||...| ....|...  ....|||.||.|||||..  ||.
pglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylm

NqmkrttpdlfyssdTILYNTISFFNQMRANNSECVTVPSQKRYV
               .  ..  . ....|. .. .|. |.| |..
k..............klglsleealalvrsrrpgavpnpgqlrfL
subfamily_PRL_pd Subfamily PRL 57-147 1.7e-08 28.7 In-house 22-115 (151) alignment 
Range on Protein: 57-147
Range on HMM: 22-115/151.0
EVYNFFEKYHSAHWKILNVAMEISYSTTKVG---GNVIVMGFEDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQ
 . .| |. .  . | .  . |..|.|.|.     .|. . |.| ..||  .. . .| ...    . ....|||| || ||.  ...  ||..
tlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea
0047943 (Phosphotyrosine protein) phosphatases II 61-194 7.5e-18 60.4 In-house 141-268 (273) alignment 
Range on Protein: 61-194
Range on HMM: 141-268/273.0
FFEKYHSAHWKILNVAMEI-SYSTTKVGGNVIVMGFEDHTPP-PFLLLLDIIETMNKWLDSD-EQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFy
. . .. ..... .. ..  ... ...   . ..|. ||  |  .  ||..|| ..|.| .. ......|||.||.|||||.|  .|. .. ...  .  
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.

ssdtiLYNTISFFNQMRANnseCVTVPSQKRYVGYYI
     ..... .. ..| .   .|. |.| |.. ...
.....vleavkllrsqRpg...mvqtpeqyrflyeal
0051299 (Phosphotyrosine protein) phosphatases II 61-196 7.5e-17 57.1 In-house 153-284 (288) alignment 
Range on Protein: 61-196
Range on HMM: 153-284/288.0
FFEKYHSAHWKILNVAMEI-----SYSTTKVGGNVIVMGFEDHTPPP-FLLLLDIIETMNKWLDsDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTT--
. . .. ..... .. ..        ....      .... ||  |. . ||||... ..|.|  . .....|||.||.|||||.|  .|. .. ...  
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

PDlfyssdtiLYNTISFFNQMRANnseCVTVPSQKRYVGYYIQY
.|        ..... .. ..| .   .|. |.| |.| ... .
vd........vleavkrlreqRpg...mvqtpeqyrfvyealle
subfamily_PTPRB_pd Subfamily PTPRB 65-150 1.7e-07 25.6 In-house 160-247 (293) alignment 
Range on Protein: 65-150
Range on HMM: 160-247/293.0
YHSAHWKILNVAMEISYSTTKVGgNVIVMGFEDHT-PPPFLLLLDIIETMNKWL-DSDEQNVIAVHCKAGKGRTGTVISS-YLINQMKR
 .  .| | ....| . ...||  .   . . ||  |     |||...|..... .. ... | ||| || ||||| |.   |......
eeledwvirelkiekekeerkvr.qyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee
0049772 (Phosphotyrosine protein) phosphatases II 66-193 9.5e-17 57.1 In-house 159-273 (314) alignment 
Range on Protein: 66-193
Range on HMM: 159-273/314.0
HSAHWKILNvamEISYSTTKVGGNVIVM---GFEDHTPPPFLLLLDIIETMNKWldsDEQNVIAVHCKAGKGRTGT-VISSYLINQMKrttpdlfYSSDT
. |... |.   |. |.  .. ...|      ..|...|..  .....| ....   |......|||||||||||| |.  ||. ...       .| ..
taadlellk...eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vslee

IlyntISFFNQMRANNSECVTVPSQKRYVGYY
.    .... ..|  |   ........|. ..
a....ledvrlkRpinpnpgfieqleqyefil
0036941 (Phosphotyrosine protein) phosphatases II 73-197 1.1e-15 53.1 In-house 155-276 (297) alignment 
Range on Protein: 73-197
Range on HMM: 155-276/297.0
LNVAMEI-SYSTTKVGGNVIVMGFEDHTPPP-FLLLLDIIETMNKWLDSD-EQNVIAVHCKAGKGRTGTVISSYLINQMKRTT---P--DlfyssdtiLY
 .. ..   .. ...     ..|  || .|. .  |||.|| ..|.|.   ..... |||.||.||.||.|  .|. |. ..    .  |        ..
rtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd........il

NTISFFNQMRANnseCVTVPSQKRYVGYYIQYL
... .. ..|..   .|. ..| |.. .....|
eavkklReqRpg...avqtleqyrflyeallel
subfamily_PTPMT1_pd Subfamily PTPMT1 82-150 8.6e-09 30.1 In-house 68-135 (171) alignment 
Range on Protein: 82-150
Range on HMM: 68-135/171.0
STTKVGGNVIVMGFEDHT-PPPFLLLLDIIETMNKWLDsdEQNVIAVHCKAGKGRTGTVISSYLINQMKR
. .|.| . . .   |.|  | .  |.. .| ..|  .  ... . ||||||.||..|....||. . | 
ewkklgveqlqlatvDfteapdleklekgvefiekvas..kgkrvYvHCkaGrgRsatlvacylmkkekl
0051429 (Phosphotyrosine protein) phosphatases II 86-150 8.5e-10 34.2 In-house 68-178 (272) alignment 
Range on Protein: 86-150
Range on HMM: 68-178/272.0
VGGNVIVMGFEDHTPPPFLLLL------------------------------------------------DIIETMN----KwldsdeQNVIAVHCKAGK
 | ..... ..|...|. |..                                                 . . ..     .      .. . |||.|||
pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGk

GRTGTVISSYLINQMKR
.|||||.  .|. .   
dRTGtvvallllllgvs
0050432 (Phosphotyrosine protein) phosphatases II 92-197 7.1e-15 50.6 In-house 204-298 (308) alignment 
Range on Protein: 92-197
Range on HMM: 204-298/308.0
VMGFEDHTPPP-FLLLLDIIETMNKWLdsdEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTpdL--FyssdtiLYNTISFFNQMRANnseCVTVPSQKR
 .. .||  || .  |||..| ..|.|   ....|.|||.|| |||||.|  .|. .. ...            ..... .. ..|..   .|. |.| .
ytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqleke..ggvd......vfeavkklReqRpg...mvqtpeqyl

YVGYYIQYL
.. ......
flyralley
subfamily_DSP23_pd Subfamily DSP23 92-150 1.2e-07 26.5 In-house 56-112 (148) alignment 
Range on Protein: 92-150
Range on HMM: 56-112/148.0
VMGFEDHTPPPFLLLLDIIETMNKWldSDEQNVIAVHCKAGKGRTGTVISSYLINQMKR
 .. .|..||    . .... ...    . .. ..|||  |.|||||... ||. . | 
rlriddyhppaleqvvefvrvveea..eekneavsvhcllgrgrtgtmlacylvkerkl
Y_phosphatase Protein-tyrosine phosphatase 93-186 1.1e-08 30.2 Pfam-A 141-225 (235) alignment 
Range on Protein: 93-186
Range on HMM: 141-225/235.0
MGFEDHT-PPPFLLLLDIIETMNKWLdSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDlfyssdtilYNTISFFNQMRANNSECVTVPSQ
 . .||. |     |||.|. ..|.  ..... . |||.|| |||||...  .. .. ... .          .  .. ...|..  ..|.  .|
tnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.........vdvlqivkelRkqRpgmvqsleq
Y_phosphatase Protein-tyrosine phosphatase 93-186 1.1e-08 30.2 In-house 141-225 (235) alignment 
Range on Protein: 93-186
Range on HMM: 141-225/235.0
MGFEDHT-PPPFLLLLDIIETMNKWLdSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDlfyssdtilYNTISFFNQMRANNSECVTVPSQ
 . .||. |     |||.|. ..|.  ..... . |||.|| |||||...  .. .. ... .          .  .. ...|..  ..|.  .|
tnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.........vdvlqivkelRkqRpgmvqsleq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 93-190 3e-06 20.8 In-house 97-186 (440) alignment 
Range on Protein: 93-190
Range on HMM: 97-186/440.0
MGFEDHTPPPFL-LLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQM-KRttpdlfysSDTIlyNTISFFNQMRANNSECVTVPSQKRYV
 |. |.  | |   .| .|. .|.  .   .  . ||| || |||| .|.   | .  ||        || |  . .|| | || |  . | .| |  .|
qgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakr........sdqi..difsfinsmrnnrpqmvqtpeqyafv
PTPc_DSPc_SM00012 95-190 6.3e-12 41.0 In-house 10-99 (105) alignment 
Range on Protein: 95-190
Range on HMM: 10-99/105.0
FEDH-TPPPFLLLLDIIETMNKWLDSDE-QNVIAVHCKAGKGRTGTVISSYLINQMKRTTPdlfyssdtILYNTISFFNQMRANNSECVTVPSQKRYV
  || .| .   .|.... ..|.    | .. . |||.|| |||||..  ... |. ...           ..   .....|   . .|.   |  ..
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket........kevdifqivkelrkqRpgmvqteeqylfl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 96-151 2.6e-07 25.0 In-house 190-246 (319) alignment 
Range on Protein: 96-151
Range on HMM: 190-246/319.0
EDHTPPPFLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVIS-SYLINQMKRT
..  |   ..|||... ..|  .  ..  | ||| || ||||| |  .  ....|. 
dhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkee
subfamily_ptpA1_pd Subfamily ptpA1 96-145 6.7e-06 20.1 In-house 202-252 (418) alignment 
Range on Protein: 96-145
Range on HMM: 202-252/418.0
EDHTPPPFLLLLDIIETMNKWLDSDEQNV-IAVHCKAGKGRTGTVISSYLI
 ||| |   ||  | .  |. . | ..|| | ||| || |||||. .. ..
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavim
0048567 (Phosphotyrosine protein) phosphatases II 97-157 1.3e-08 29.4 In-house 47-112 (157) alignment 
Range on Protein: 97-157
Range on HMM: 47-112/157.0
DHTPPPFLLLLDIIETMNKWLD--SDEQNVIAVHCKAGK---GRTGTVISSYLINQMKRTTPDLFY
|. |..  .| . |  .||.|.  . . ..||||||||    |||.|.|..|||  .. |  . . 
dfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaia
subfamily_PTPN12_pd Subfamily PTPN12 97-152 3.8e-08 27.6 In-house 182-238 (290) alignment 
Range on Protein: 97-152
Range on HMM: 182-238/290.0
DHT-PPPFLLLLDIIETMNKWLDsDEQNVIAVHCKAGKGRTGTVISS-YLINQMKRTT
||  |  .  ||..||....  . .|.. ..||| || |||||.|.  |  ...|. .
DhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaek
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 97-187 6.7e-06 20.3 In-house 183-260 (288) alignment 
Range on Protein: 97-187
Range on HMM: 183-260/288.0
DH-TPPPFLLLLDIIETMnkwldSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLfyssdtilyNTISFFNQMRANNSECVTVPSQK
|.  |  .|  | ..| .      . |. | ||..|| |||||.| . .. .. | . .|            |.....|..  .....  | 
ddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddfl.........girsllaklreerfkaiqtemqy
PTPc_motif_SM00404 98-155 9.2e-08 27.1 In-house 61-113 (140) alignment 
Range on Protein: 98-155
Range on HMM: 61-113/140.0
HTPPPFLLLLDIIETMnkwldSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDL
.. . .  .||.||..      ...  . |||.||  |..|.|  ||..... .. . 
klskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaea
subfamily_PTPRK_pd Subfamily PTPRK 99-151 3.1e-06 21.2 In-house 188-239 (314) alignment 
Range on Protein: 99-151
Range on HMM: 188-239/314.0
TPPPFLLLLDIIETMNKWLDSdEQNVIAVHCKAGKGRTGTVISSYLINQMKRT
.|     ||...  ..|. .  |.  | ||| || ||||| |    . .| ..
vPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier
DSPc_SM00195 102-186 2.1e-08 29.2 In-house 176-250 (263) alignment 
Range on Protein: 102-186
Range on HMM: 176-250/263.0
PFLLLLDIIETMNKWLDSDeQNVIAVHCKAGKGRTGTVIS-SYLINQMKRTTPdlfyssdtilYNTISFFNQMRANNSECVTVPSQ
    .|.......|. ..  .. | |||.|| |||||... ...........           ..  . ....| .   .|.   |
stksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk..........vdifeivkelRkqRpgmvqtleq
PTPc_SM00194 102-186 2.1e-08 29.2 In-house 176-250 (263) alignment 
Range on Protein: 102-186
Range on HMM: 176-250/263.0
PFLLLLDIIETMNKWLDSDeQNVIAVHCKAGKGRTGTVIS-SYLINQMKRTTPdlfyssdtilYNTISFFNQMRANNSECVTVPSQ
    .|.......|. ..  .. | |||.|| |||||... ...........           ..  . ....| .   .|.   |
stksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk..........vdifeivkelRkqRpgmvqtleq
subfamily_PTPN6_pd Subfamily PTPN6 103-196 7e-08 26.8 In-house 208-295 (306) alignment 
Range on Protein: 103-196
Range on HMM: 208-295/306.0
FLLLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVIS-SYLINQMKRTTPDlfysSDTILYNTIsffNQMRANNSECVTVPSQKRYVGYYIQY
.| .|. ... .. | . |.  | ||| || |||||.|    |.......  |     |. .....   ...|.  |  | . .| ..| . |..
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgld....adidiqklv...ksvreqrsglvqteqqykfvykaikk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 105-150 2.4e-07 25.1 In-house 196-242 (318) alignment 
Range on Protein: 105-150
Range on HMM: 196-242/318.0
LLLDIIETMNKWLDSDEQNVIAVHCKAGKGRTGTVIS-SYLINQMKR
 |||.. . .|.  . ....|.||| || ||||. |  . |....| 
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerika
DSPc Dual specificity phosphatase, catalytic domain 106-155 3.3e-08 28.5 Pfam-A 59-106 (133) alignment 
Range on Protein: 106-155
Range on HMM: 59-106/133.0
LLDIIETMNKWldSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDL
| ...| ..|    .... ..|||.||  |..|.|  ||..... .. . 
leeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA
DSPc Dual specificity phosphatase, catalytic domain 106-155 3.3e-08 28.5 In-house 59-106 (133) alignment 
Range on Protein: 106-155
Range on HMM: 59-106/133.0
LLDIIETMNKWldSDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDL
| ...| ..|    .... ..|||.||  |..|.|  ||..... .. . 
leeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 106-190 8.6e-07 23.3 In-house 197-271 (288) alignment 
Range on Protein: 106-190
Range on HMM: 197-271/288.0
LLDIIETMNKWLDSDeQNVIAVHCKAGKGRTGTVIS-SYLINQMKRttpdlfysSDTIlyNTISFFNQMRANNSECVTVPSQKRYV
||.......   ..| .. | ||| || ||||| |.   ||.....        .|.|  . ... ...| .    | . .|  ..
llellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidavee........edyi..DvagtvaklRkqRallvqtlkqYefi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 106-189 5.2e-06 20.6 In-house 197-270 (315) alignment 
Range on Protein: 106-189
Range on HMM: 197-270/315.0
LLDIIETMNKWLDSDEqNVIAVHCKAGKGRTGTVISSY-LINQMKrttPDlfysSDTILYNtisFFNQMRANNSECVTVPSQKRY
|...| |.... ...    | |||.||.||||| |.   ...|..    .        .||   | ...|.|  . | |  | ..
lmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqae...ae....naidvyn...fitgvrqnrikmvqvaeqyqf
subfamily_DSP19_pd Subfamily DSP19 107-152 1.1e-06 23.0 In-house 72-119 (152) alignment 
Range on Protein: 107-152
Range on HMM: 72-119/152.0
LDIIETMNKWLDSDE--QNVIAVHCKAGKGRTGTVISSYLINQMKRTT
|...... .....    .... |||.||  |. .|. .||... . ..
lsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsl
subfamily_DSP11_pd Subfamily DSP11 109-152 2.4e-06 21.6 In-house 101-146 (178) alignment 
Range on Protein: 109-152
Range on HMM: 101-146/178.0
IIETMNKWLD--SDEQNVIAVHCKAGKGRTGTVISSYLINQMKRTT
 .|.....|.   |....|.|||  |  ||| .|  |||...   .
fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyep
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-141 8.5e-06 19.7 In-house 247-281 (350) alignment 
Range on Protein: 109-141
Range on HMM: 247-281/350.0
IIETM--NKWLDSDEQNVIAVHCKAGKGRTGTVIS
.|...  ...||..... | ||| || |||||...
liddlfaeshldnarsspilvhCsaGvGrtGtlvt
subfamily_RNGTT_pd Subfamily RNGTT 110-149 5.8e-07 23.4 In-house 101-140 (189) alignment 
Range on Protein: 110-149
Range on HMM: 101-140/189.0
IETMNKWLDSDEQNVIAVHCKAGKGRTGTVISSYLINQMK
|. .... .   ..||.|||. |  ||| .| |||.....
iklveeffkknpeevigvhCthGfnRtGFlivsyLveked
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 229-347 1e-11 36.2 Pfam-A 17-133 (134) alignment 
Range on Protein: 229-347
Range on HMM: 17-133/134.0
PHFNIEIhlNYNPKIR--NLPII---IRGSNTGIVFYQDFYSYILREKGIIAKGDTLIKFNS----LDSPQCVFRFLFHTSFLLTpttqdsqSIITLYFQ
|.|...   ...||..  |        ..|..    ...   ..  ..... .|| |..| .    | . ...||. |.|||. .       .  .|...
Pnfktrg..gckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek.......nqnvltlp

KDNLDGgSGGAFlDSKYKTDFAIRVLLE
|..||.       | |.. .|......|
kneLDk.alkdk.dkkfsknfkvelvfe