Gene pten in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP044_AA protein Get Run
DdisP044_AA_4-183 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_VSP_pd Subfamily VSP 3-195 6.4e-67 219.5 In-house 14-211 (212) alignment 
Range on Protein: 3-195
Range on HMM: 14-211/212.0
NLLRVAVSKQKRRYQKNGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFEMID
.. |  ||..||||...|.||||.|.|. |.|| |||   . ..|||...| ||||. |.||.||.|||||| ||.. |  ||     |||| |..| . 
kaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleell

AFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQ-----KGVTIPSQIRYVGYFGRSIRESIKYVPRNVTL
 |...|  |...| ||. .|||| |||||| ..|..|.. ........|| ...  || ..     .||  ||| |||||.   .    . .| ..||
vftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppaktl
subfamily_PTEN_pd Subfamily PTEN 5-185 3.4e-85 279.7 In-house 2-182 (184) alignment 
Range on Protein: 5-185
Range on HMM: 2-182/184.0
LRVAVSKQKRRYQKNGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAF
|| .|||.|.|....|.||||.|||.||.|||.|.||.|...|| ..||..||...||||.|.|||.||| ||..|| |||  |||||||.|..|.....
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFGRSIRES
..|...|..||.||..|.||||||||||..|...|.........|..|...|. || |.||||||||.||| |. . ..|.
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
0037934 (Phosphotyrosine protein) phosphatases II 5-178 3e-32 107.5 In-house 5-237 (243) alignment 
Range on Protein: 5-178
Range on HMM: 5-237/243.0
LRVAVSKQKRRYQ--------------KNGYDLDLAYITDNIVAMGFPSEKVEGV----FRNPMKDVQ--------------------------------
..  ... |.||.               . ....| |.|... |...| ..        | . ... .                                
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-RFLDQYHKDHFKVYNLCSER--VYDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKE-------DSKNIAVIHCKAGKGRTGLMICCWLMYCG
 ..|...|.|...|..|. |.   .|....  .. |.|. ||..|. .| . .|...| ....|       ||..  ..||.||.||||..|...||.  
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

MWKNTEDSLRFYAALRTYnqKGVTIPSQIRYVGYF
.  . |. .... . | .  |.|..|||.|.. ..
lgvdleeavkllreqRpg..kavqtpsqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 7-178 1.1e-27 92.5 In-house 6-238 (245) alignment 
Range on Protein: 7-178
Range on HMM: 6-238/245.0
VAVSKQKRRY-------------QKNGYDLDLAYI----------TDNIVAMGFPSEKVEGVFRNPMKDVQ-----------------------------
  ..|.|.||             .  |.|||. ||          |... |...|...  . | . ... .                             
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

------RFLDQYHKDHFKVYNLCSER-VYDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGM--
      ..|. .|.|...|..|. ..  .| |..  .. |.|..||..|   |... |.. |. ...|||..  ..||.||.||||..|...||.. .  
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

--WKNTEDSLRFYAALRtynQKGVTIPSQIRYVGYF
    . |. ....   |    . |..|||.|.. ..
elgvsleeavkelrsqR...pgavqtpsqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 8-178 2.1e-34 114.8 In-house 54-284 (297) alignment 
Range on Protein: 8-178
Range on HMM: 54-284/297.0
AVSKQKRRYQ--------------KNGYDLDLAYI-----------TDNIVAMGFPSEKVEGVFRNPMKDVQ----------------------------
 ..| |.||.              ..|.|||. ||           |....|...|...  . | . ... .                            
penkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggty

-----RFLDQYHKDHFKVYNLCSERvYDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTGLMICCWLMYCGM---
     ..|. .|.|...|..|. .. .. |... .. |... ||..|. .| .. |.. |. ...|. ...  ..||.||.|||| .|...||.. .   
gdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

-WKNTEDSLRFYAALRtynQKGVTIPSQIRYVGYF
   . .. ....   |    ..|..|||.|.. ..
ggvdvleavkelreqR...pgavqtpsqyrflyda
0040439 (Phosphotyrosine protein) phosphatases II 8-178 6.5e-29 96.7 In-house 9-241 (249) alignment 
Range on Protein: 8-178
Range on HMM: 9-241/249.0
AVSKQKRRYQ---------------KNGYD--------LDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQ------------------------------
 ..| |.||.               .....        .|. ||.....|...| ..  . |.. ... .                              
penkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

-----RFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYY-PFDDHNAP-QFEMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTGLMICCWLMYCGM-W
     ..|. ..||...|..|. ...|| .... .. .| .. ||..|  || ...|.. |. ...|. ...  ..||.||.||||..|...||.. . .
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

KNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYF
... | .  .. ||..  ..|. |.|.|.. ..
elgvdleeavkllrsqRpgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 9-178 1.2e-29 99.0 In-house 44-272 (278) alignment 
Range on Protein: 9-178
Range on HMM: 44-272/278.0
VSKQKRRY-------------QKNGYDLDLAYI----------TDNIVAMGFPSEKVEGVFRNPMKDVQ-------------------------------
 .|.|.||             .  |.|||. ||          .....|...|... .. |.. ... .                               
enkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygd

---RFLDQYHKDHFKVYNLCSERVYDHSKFYGR-VGYYPFDDHNAP-QFEMIDAFCRDVDAWMKeDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKN-T
   ..|...|.|...|..|. .. .|. ..... . |... ||..| .....  |...|. ... ||..  ..||.||.||||..|...|... . |. .
ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekegg

EDSLRFYAALRTYNQKGVTIPSQIRYVGYF
 | .  .. ||..  . |. |||.|.. ..
vdleeavkelreqRpgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 9-178 8.1e-29 96.7 In-house 54-299 (307) alignment 
Range on Protein: 9-178
Range on HMM: 54-299/307.0
VSKQKRRYQK-------------------------------------NGYDLDLAYI----------------------------------TDNIVAMGF
..| |.||.                                      .||||....|                                  .... |. .
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PSEKVEGVFRNpmkDVQRFLDQYHKDHFKVYNLCSERvYDHSKFYGRVGYYPF---DDHNAPQ-FEMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTG
|.|. | ...|   .. ..|. .|.|...|..|. .. .| ...  .| ....    ||..|. ||.. .|.. |.....|. ...  ..||.||.||||
Pdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtG

LMICCWLMYCGMWKNTE----DSLRFYAALRTYNQKGVTIPSQIRYVGYF
 .|...||.... |. .    | |  .. ||    ..|. |.|.|.. ..
tfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 9-178 1.1e-28 95.9 In-house 42-271 (317) alignment 
Range on Protein: 9-178
Range on HMM: 42-271/317.0
VSKQKRRY-------------QKNGYDLDLAYI----------TDNIVAMGFPSEKVEGVFRNPMKDVQ-------------------------------
..|.|.||             .  |.|||. ||          .....|...| ..  . | . ... .                               
enkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltyg

----RFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPF-DDHNAP-QFEMIDAFCRDVDAWMKeDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNT
    ..|. ..........|. |  .|  ... .. .|.. .||..|  .. . .|.. |..... |...  ..||.||.|||| .|...||.. . |. 
dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg

edSLRFYAALRTYNQK---GVTIPSQIRYVGYF
   . .. |.......   .|. |.|.|.. ..
..gvdveeavkelreqRpgavqtpeqyrflyda
0044763 (Phosphotyrosine protein) phosphatases II 9-181 2.9e-23 77.8 In-house 7-169 (178) alignment 
Range on Protein: 9-181
Range on HMM: 7-169/178.0
VSKQKRRYQKNGYDLDLAYITDNIVAMGFPSekvegvfrnpmKDVQRFLDQYHKDHfkVYNLCSE--------RVYDHSKFYGRVGYYPFDDHNAPQ-FE
|. .....   .. ... .|.... ....|.            |  ..| ... .|  . ||..|          |. ...  .. ..|..||..|. .|
vllsnleglersdyinaseilpglylgslpp...........addlellkelgith..ivnlteelelgflkcdpywpeeagiqylhipipDhgvpdlle

MIDAFCRDVDAWMKEDSKNIAViHCKAGKGRTGLMICCWLMYCGMWkNTEDSLRFYAALRtynQkGVTIPSQIRYVGYFGRS
....|.. ......|. ....| ||.||.||.|......||..  . . |. .... . |     .|. |.|.|.. .| . 
hflefvefieealdekggpvlV.HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelr
PTEN_1 11-179 1.7e-45 150.3 In-house 8-189 (196) alignment 
Range on Protein: 11-179
Range on HMM: 8-189/196.0
KQKRRYQKNGYDLDLAYITDNIVAMG-FPSEK-----VEGVFRNPMKDVQRFLDQYHKDH-FKVYNLCSERV-----YDHSK-FYGRVG--YYPFDDHNA
  |... ... .|||.|||. |.||| .||..      ||..|...|||...||. ..|. . |.||..|.      ||... | ..|    .|..||.|
sskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhga

PQFEMIDAFCRDVDAWMKEDS-KNIAVIHCKAGKGRTGLMICCWLMYCGMwKNTEDSLRFYAALRTYNQKGvtIPSQIRYVGYFG
| .... ..|.... |...|. .|....|||||.||.|......|||.|   . .. |..... |. . .   .||| |.. || 
pslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfa
0046845 (Phosphotyrosine protein) phosphatases II 11-177 3.3e-24 81.2 In-house 29-268 (284) alignment 
Range on Protein: 11-177
Range on HMM: 29-268/284.0
KQKRRYQK-----------------------------NGYDLDLAYITDNIVAMGFPSEK-----------------------------VEGVFRNPMKD
. | ||.                              .|||||| ||. ...|. .| ..                                 .......
lsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplege

VQRF-------LDQYHKDHFKVYNLCSERV--YDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKE-DSKNIAVIHCKAGKGRTGLMICCWLMY
|...       |. ..||...|..|. ...   . |..     | .. ||..|. .| . .|.|.|. .... ....  |.||.||.|||| .|...|..
vltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdlll

CGMWKN----TEDSLRFYAALRTYNQKGVTIPSQIRYVGY
. . |.    . | |  .. ||..    |. ..|.|.| .
eqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye
0041856 (Phosphotyrosine protein) phosphatases II 12-181 8.6e-32 105.6 In-house 3-169 (182) alignment 
Range on Protein: 12-181
Range on HMM: 3-169/182.0
QKRRYQK---NGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFK-VYNLCsERVYDHSKFYG---RVGYYPFDDHNAPQFEMIDAF
 |.||..   . ...|| ||..|......|. . .   ......| .||..... ... . ||. |. |. ....    .. |.|..||..| .... .|
dknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldf

CRDVDAwmkedSKNIAVIHCKAGKGRTGLMICCWLMYCGMwKNTEDSLRFYAALRtynQKGVTIPSQIRYVGYFGRS
...| .     ...  ..||.||.|||| .....||..    . |. ....   |    ..|..|.|.... .. . 
ieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqlalle
subfamily_Tensin_pd Subfamily Tensin 14-199 1.1e-43 141.9 In-house 2-188 (189) alignment 
Range on Protein: 14-199
Range on HMM: 2-188/189.0
RRYQKNGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLcSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMK
 || .. .|||| |||. |.|. ||.| .|  .|. .||| ..|.. |.|.. |.|| ||. || ||.  .|  . . |. || .| . . |...|.|.|
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

EDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKG--VTIPSQIRYVGYFGRSIRESIKYVPRNVTLKKIV
.| .|..|.||| ||||.|... ... |  . . .. .|  .|  | ...|   .| ||| ||| ||   .  .||   . . |. ..
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvi
0043147 (Phosphotyrosine protein) phosphatases II 14-182 4.5e-35 116.3 In-house 4-160 (172) alignment 
Range on Protein: 14-182
Range on HMM: 4-160/172.0
RRYQKNGYDLDLAYITDNIVAMGFPsekvegvFRNPMKDVQRFLDQYHKDHfkVYNLCsER---VYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDA
...  | ..||| ||.|...|. .|       .||.. |. |.| ... .|  ..||. |.    .. .... .. |.|..||..| .|... |.. .| 
gsdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefide

WMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMwknteDSLRFYAALRTYNQKGVTIPSQIRYVGYFGRSI
.. .....  ..||.||.||||......||..|.     . .  .| .|.   ..|..|||.|.. || . .
llalspggpvlVHCsaGvgRtgtlvaaylmllgl.....sleeavalvrekRpgavqnpsqyrflyyfekll
0046846 (Phosphotyrosine protein) phosphatases II 15-180 7.4e-34 112.4 In-house 2-170 (176) alignment 
Range on Protein: 15-180
Range on HMM: 2-170/176.0
RYQKNGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQ-----------YHKDHFKVYNLCSErvydHSKFYGRVGYYPFDDHNAPQFEMIDA
|... |.|||| ||..|......|  . ... |. ..........           ......|..|...|      |.  .. ..|..||..|..| .. 
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

FCRDVDAWMKEDskNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYnqKGVTIPSQIRYVGYFGR
... .. . ||.  .  ..||.||.||||......|.....  . |. |... . | .  . |. |.|.|.. .| .
llefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefel
0045098 (Phosphotyrosine protein) phosphatases II 18-182 2.5e-30 101.3 In-house 2-271 (278) alignment 
Range on Protein: 18-182
Range on HMM: 2-271/278.0
KNGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMK------------------------------------------------------------------
.....||| .........|.|||  .........                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------DVQRFlDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFE---MIDAFCRDVDAWMK----------
                         ..... | |.. ...|.||..|| .. | .   . |.|..||..| ..    .. ... .....|          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--EDSKNIAVIHCKAGKGRTGLMICCWLMYCGMwKNTEDSLRFYAALRTYNQK-GVTIPSQIRYVGYFGRSI
  .||..  ..||.||.|||| .....||.. . ... | |  .. ||..     |....|.|.. .| . .
llldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllel
0036282 (Phosphotyrosine protein) phosphatases II 19-183 3e-45 149.4 In-house 6-170 (174) alignment 
Range on Protein: 19-183
Range on HMM: 6-170/174.0
NGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKN
| ..||| |||....|...| . .| ....  ..| ..|. ......|..|...|. .| ...  .. |.|..||..| ..... |.. |. ...||...
naspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpgg

IAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFGRSIR
  ..||.||.||||......||..|.. ...| |.....||... ..|..|||.|.. ||.. ..
pvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
0036941 (Phosphotyrosine protein) phosphatases II 20-178 2.2e-17 58.7 In-house 73-272 (297) alignment 
Range on Protein: 20-178
Range on HMM: 73-272/297.0
GYDLDLAYI---------------------TDNIVAMG-------------FPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRV
||||. ..|                     .  || .              .|.|. | .  ....   .  .....|......|. . . .  ... ..
gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvth

GYYP-FDDHNAPQ-FEMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTGLMICCWLMYCGMW----KNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYF
 .|.  .||..|. .. . .|.. |. ..|.  |..  ..||.||.||.| .|...||.. .      .. | | ..  ||..    |. ..| |.. ..
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
subfamily_CDKN3_pd Subfamily CDKN3 21-154 2.1e-06 21.5 In-house 31-169 (202) alignment 
Range on Protein: 21-154
Range on HMM: 31-169/202.0
YDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVY---NLCSERVYDHSKFYGRVG----YYPFDDHNAPQFEMIDAFCRDVDAWMK
 ||    |.. .   ..|  | . | |.  ||.. .  |  .| | .    .|   ||    . | ..|    .||. |  .|.      .  ..   .|
ldlsrvniaeklglsalpgckfddvrrsvekdieelksqgvedvfvlctrgelskyrvrrlldlyqqaglivhhypiadglvpdiasclkileelrinlk

EDSKniAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRF
.  |  ...||  | ||. |.| | |.|     . .|..  
ayrk..tlvhcygglgrsslviaclllylddtiepkdaidk
subfamily_Auxilin_pd Subfamily Auxilin 22-182 1.3e-42 138.3 In-house 8-164 (166) alignment 
Range on Protein: 22-182
Range on HMM: 8-164/166.0
DLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLcSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAV
|||..|||  |. | ||.|.||  ..| ..||. ||.  |.....|||| |.| |...|. .||  . .  ..||. | . . ||....|.|.|.||. |
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQkgvTIPSQIRYVGYFGRSI
.||| |.  ...... .|..| .....|...|.... |.        ||. ||. |..  .
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladll
0049772 (Phosphotyrosine protein) phosphatases II 22-179 5.4e-26 87.5 In-house 118-274 (314) alignment 
Range on Protein: 22-179
Range on HMM: 118-274/314.0
DLDLAYITD---------------------NIVAMGFPsekvegvfrnpmkdvqrflDQYHKDHFKVYNlcsERVYDHSKFYGRVGYY---PFDDHNAPQ
||.. .|                       .. ..|..                   ....  ... ..   |..||...| ...  |   |..|..|| 
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng...................neptaadlellk...eelydpelferlgikylripvpDgsapl

FEMIDAFCRDVDAWmkeDSKNIAVIHCKAGKGRTG-LMICCWLMYCGMWkNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFG
.|..|.|.. ....   | ..  ..|||||||||| ......||..  . . |. |... . |..| . ..|.....|. .. 
ledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefile
0051082 (Phosphotyrosine protein) phosphatases II 23-178 5.3e-26 86.4 In-house 6-147 (151) alignment 
Range on Protein: 23-178
Range on HMM: 6-147/151.0
LDLAYITDNIVAMGFPSEkvegvfrnpmkDVQRFLDQYHKDHfkVYNLCS--ERVYDHSKFYG---RVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSK
... |.|... ..|.|..           |. ..| ... ..  ..||.|  || |... .     .| ..|..|. .|..... ......  .. ....
infsyvtgglyrsggpla...........dflellkelgikt..ivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NIAVIHCKAGKGRTGLMICCWLMYCGmwKNTEDSLRFYAALRTynqkGVTIPSQIRYVGYF
.  ..||.|||||||......||..|   . |. |..| . |.    ||..|.| ... .|
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlf
subfamily_CDC14_pd Subfamily CDC14 24-142 1.6e-10 35.3 In-house 171-288 (328) alignment 
Range on Protein: 24-142
Range on HMM: 171-288/328.0
DLAYIT-DNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGrVGY----YPFDDHNAPQFEMIDAFCRDVDAWmkedsKN
|. .|. | ..|.  | .| .   . |..  ...|. ..| . .      ...||..||    |.      | |   |. ...  | . ..       . 
DfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftd.aGfdhkDlffiDGstPsdaivkkfleiaeka.....eG

IAVIHCKAGKGRTGLMICCWLMYC
 ...||||| |||| .| |.||. 
aiavhCkaGLGrtGtLiacylmkh
0038934 (Phosphotyrosine protein) phosphatases II 27-177 4.4e-39 129.5 In-house 15-165 (194) alignment 
Range on Protein: 27-177
Range on HMM: 15-165/194.0
YITDNIVAMGFPSEK-----VEGVFRNPMKDVQRFLDQYHKDHFKVYNLC-SERVYDHSKFYGRVGYY---PFDDH-NAPQFEMIDAFCRDVDAWMKEDS
.||....|...|...     .|.. |....|. |.|.........|..|. .||.||...|...  .|   || |. ..|..|... |.. || ...||.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNIAVIHCKAGKGRTGLMICCWLMYCGMWkNTEDSLRFYAALRtynqkgvtiPSQIRYVGY
... ..|||||.||||......|.|.  . . |.......  |         |..|....|
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdy
0049260 (Phosphotyrosine protein) phosphatases II 34-180 1.1e-33 111.5 In-house 6-147 (152) alignment 
Range on Protein: 34-180
Range on HMM: 6-147/152.0
AMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGL
||.|.    .|. .|...|. |.| ... ..  ... ..|. ..  ..| .. ..|..||..|.....  |. ... ....|...  ..||.||.||||.
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

MICCWLMYcgmwkNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFGR
.....||.     .  . . ..| .|. . ..|. |.|.|.. .| .
lvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefek
0048179 (Phosphotyrosine protein) phosphatases II 37-179 1.4e-26 88.3 In-house 3-141 (144) alignment 
Range on Protein: 37-179
Range on HMM: 3-141/144.0
FPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYG-RVGYYPFDDHNAPQF-EMIDAFCRDVDAWMKEDskNIAVIHCKAGKGRTGLM
.||| ..|...... .....    . ..  |.||..|. ... ...| .. ..|..||..|.. |....|.. ......|.  .  ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ICCWLMYcgmwKNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFG
....||.    |.  .    .| .|...  .|. |.|.|.. ...
vaaylmk....klglsleealalvrsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 37-178 3.1e-25 83.9 In-house 3-138 (145) alignment 
Range on Protein: 37-178
Range on HMM: 3-138/145.0
FPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHsKFYGRVGYYPFDDHNAPQF-EMIDAFCRDVDAWMKEDskNIAVIHCKAGKGRTGLMI
.||| ..|...... .....    . ..  |.||.||. .   ..  .. |.|..||..|.. |....|.. .....||.  .  ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CCWLMYCgmwkNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYF
...||..    .  .    .. .|..  ..|. |.|.|.. .|
aaylmll....lgvsleealelvrsqrpgavpnpgqlrflyef
subfamily_PRL_pd Subfamily PRL 49-155 2.8e-11 37.7 In-house 18-126 (151) alignment 
Range on Protein: 49-155
Range on HMM: 18-126/151.0
PM-KDVQRFLDQYHKDHFKVYNLCSERVYDHSKFY---GRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGM
|  . ...| .. .| . |    . |  || .|.     .|  ..||| ..|  |... . . . .  ||..|..  .|| || ||. ....  |. .||
PtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm

wkNTEDSLRFY
  ..||...| 
..kyedavefi
Y_phosphatase Protein-tyrosine phosphatase 51-172 4.3e-08 28.2 Pfam-A 106-226 (235) alignment 
Range on Protein: 51-172
Range on HMM: 106-226/235.0
K-DVQRFLDQYHKDHFKVYNLCSERvydHSKFYGRVGYYPFDDHNAP-QFEMIDAFCRDVDAWMkEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWK-N
| ....  ..|   .... . ..|.   ...    . |    ||..| . . .  ..|.|  .  |....  |.||.|| |||| ... ... . . . .
kekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaee

TEDSLRFYAALRTYNQKGVTIPSQI
. | | .   ||.  .. |.  .| 
evdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 51-172 4.3e-08 28.2 In-house 106-226 (235) alignment 
Range on Protein: 51-172
Range on HMM: 106-226/235.0
K-DVQRFLDQYHKDHFKVYNLCSERvydHSKFYGRVGYYPFDDHNAP-QFEMIDAFCRDVDAWMkEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWK-N
| ....  ..|   .... . ..|.   ...    . |    ||..| . . .  ..|.|  .  |....  |.||.|| |||| ... ... . . . .
kekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaee

TEDSLRFYAALRTYNQKGVTIPSQI
. | | .   ||.  .. |.  .| 
evdvlqivkelRkqRpgmvqsleqY
0047943 (Phosphotyrosine protein) phosphatases II 56-175 1.1e-22 76.2 In-house 141-264 (273) alignment 
Range on Protein: 56-175
Range on HMM: 141-264/273.0
FLDQYHKDHFKVYNLCSER-VYDHSKFYGRVGYYPFDDHNAP-QFEMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTGLMICCWLMYCGM-WKNTEDS
.|....||...|..|. ..  ...|...  . |... ||..| ..|..  |...|. ..... |..  |.||.||.|||| .|...|... . .... | 
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

LRFYAALRTYNQKGVTIPSQIRYV
|  .. ||..   .|. |.|.|..
leavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 56-175 2e-21 72.1 In-house 153-278 (288) alignment 
Range on Protein: 56-175
Range on HMM: 153-278/288.0
FLDQYHKDHFKVYNLCSERV--YDHSKFYGRVGYYP---FDDHNAPQ-FEMIDAFCRDVDAWMKeDSKNIAVIHCKAGKGRTGLMICCWLMYCGM-WKNT
.|. ...|...|..|. ...  .| .... .|  .    . ||..|. .|.. .|.|.|. ... ....  |.||.||.|||| .|...|... .  ...
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

EDSLRFYAALRTYNQKGVTIPSQIRYV
 | |.... ||..    |. |.|.|.|
vdvleavkrlreqRpgmvqtpeqyrfv
0050432 (Phosphotyrosine protein) phosphatases II 56-175 2.1e-16 55.6 In-house 172-291 (308) alignment 
Range on Protein: 56-175
Range on HMM: 172-291/308.0
FLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPF-DDHNAPQ-FEMIDAFCRDVDAWMkedSKNIAVIHCKAGKGRTGLMICCWLMYCGM-WKNTEDSL
.|.....|...|..|. . . |   .. .. .|.   ||..|. .|.. .|.. |. ..   ...  |.||.|| |||| .|...|... . .... | .
llseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvf

RFYAALRTYNQKGVTIPSQIRYV
  .. ||..    |. |.| ...
eavkklReqRpgmvqtpeqylfl
DSPc_SM00195 58-152 4.2e-07 24.9 In-house 140-230 (263) alignment 
Range on Protein: 58-152
Range on HMM: 140-230/263.0
DQYHKDHFKVYNLCServyDHSKFYGRVGYYPFDDHNAP-QFEMIDAFCRDVDAWMKEDsKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSL
|.... .... .       . ...   . |    ||..| . . . .. | |. . ..  ..  |.||.|| |||| ...  ...  . .......
deiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdi
PTPc_SM00194 58-152 4.2e-07 24.9 In-house 140-230 (263) alignment 
Range on Protein: 58-152
Range on HMM: 140-230/263.0
DQYHKDHFKVYNLCServyDHSKFYGRVGYYPFDDHNAP-QFEMIDAFCRDVDAWMKEDsKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSL
|.... .... .       . ...   . |    ||..| . . . .. | |. . ..  ..  |.||.|| |||| ...  ...  . .......
deiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 58-140 4.3e-06 21.0 In-house 140-224 (274) alignment 
Range on Protein: 58-140
Range on HMM: 140-224/274.0
DQYHKDHFKVYNLCSERVYDHSKFYgRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDSKN--IAVIHCKAGKGRTGLMICCWLM
.  ......| .|  . . .. . .    |  . ||..|.  . .  ....|.   .|....   .|.|| || ||||  |   . 
kiverndysvrklvlkylerersvk.hywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia
subfamily_PTPRB_pd Subfamily PTPRB 61-137 1.2e-06 22.8 In-house 161-238 (293) alignment 
Range on Protein: 61-137
Range on HMM: 161-238/293.0
HKDHFKVYNLCSERvYDHSKFYGRVGYYPFDDHNAPQF-EMIDAFCRDVDAWM-KEDSKNIAVIHCKAGKGRTGLMICC
..... . .|  |.  ....   .  .  . ||. |.  . . .|.| |. .. |. ||.  |.|| || ||||  |. 
eledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial
subfamily_PTPRK_pd Subfamily PTPRK 65-161 3.1e-08 27.8 In-house 160-252 (314) alignment 
Range on Protein: 65-161
Range on HMM: 160-252/314.0
FKVYNlcSERVYDHSKFYGRVGYYPFDDHNAPQFE-MIDAFCRDVDAWMKEdSKNIAVIHCKAGKGRTGLMICCWLMyCGMWKNtEDSLRFYAALRTY
|.|..  ..| ..  .   .. .  . ||. |. .  . .. | |... .| ..   |.|| || ||||  | .  . . | .. |. .  . | .| 
frvek..largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv.ldmier.egvvdvfnavktl
subfamily_DSP11_pd Subfamily DSP11 73-161 3.8e-09 30.7 In-house 67-159 (178) alignment 
Range on Protein: 73-161
Range on HMM: 67-159/178.0
ERVYDHSKFYGR-VGYYPF--DDHNAPQFEMIDAFCRDVDAWM--KEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKnTEDSLRFYAALRTY
.| |.....  . | |. .    |. |. |... |.. |. ..  ..|....  .||  |  ||| .|| .|. .  .. .||... .   | .
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegye.pedaieafeearGh
0048567 (Phosphotyrosine protein) phosphatases II 74-182 7.3e-10 33.4 In-house 26-138 (157) alignment 
Range on Protein: 74-182
Range on HMM: 26-138/157.0
RVYDHSKFYGRV---GYYPFDDHNAPQFEMIDAFCRDVDAWMK--EDSKNIAVIHCKAGK---GRTGLMICCWLMYCGMWknteDSLRFYAALRTYNQKG
..|.   |        . .| |.  .   ..  |.. .. ..|  |  ..  ..|||||    |||...|.|.|...  .    .   ..| || .... 
slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf....tpeeaiaplrivrpgs

VTIPSQIRYVGYFGRSI
|  . .  .. ... ..
vpfrdasyllslynltl
0051429 (Phosphotyrosine protein) phosphatases II 77-175 5.1e-12 41.5 In-house 117-217 (272) alignment 
Range on Protein: 77-175
Range on HMM: 117-217/272.0
DHSKFYGRVGYYPFDDHNAPQfEMIDAFCRDVDAwmkedsKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTED---------SLRFYAALRTYNQKGVT
. .  .    |. . ||..|| | . .. . . .      ..  ..||.|||.|||......|.. |. ..|            ..... || .  . | 
gearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavq

IPSQIRYV
 . |....
teeqylfl
DSPc Dual specificity phosphatase, catalytic domain 77-154 5.7e-08 27.7 Pfam-A 35-109 (133) alignment 
Range on Protein: 77-154
Range on HMM: 35-109/133.0
DHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWmKEDSKNIAvIHCKAGKGRTGLMICCWLMYCGMWkNTEDSLRF
.. . . ....   |....   . ...  . ...  ... |... .||.||  |.. .|...||.   . .... ..|
ikkseieylripvedetetkiskeleeavefieka.eqkgkkvl.VHCqaGisRSatliiaYlmktknl.slneAyef
DSPc Dual specificity phosphatase, catalytic domain 77-154 5.7e-08 27.7 In-house 35-109 (133) alignment 
Range on Protein: 77-154
Range on HMM: 35-109/133.0
DHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWmKEDSKNIAvIHCKAGKGRTGLMICCWLMYCGMWkNTEDSLRF
.. . . ....   |....   . ...  . ...  ... |... .||.||  |.. .|...||.   . .... ..|
ikkseieylripvedetetkiskeleeavefieka.eqkgkkvl.VHCqaGisRSatliiaYlmktknl.slneAyef
subfamily_PTPDC1_pd Subfamily PTPDC1 87-147 7.9e-11 36.7 In-house 87-144 (182) alignment 
Range on Protein: 87-147
Range on HMM: 87-144/182.0
YYPFDDHNAPQFEMIDAFCRDVDAWMKEDskNIAViHCKAGKGRTGLMICCWLMYCGMWKN
 ....|....  | |    . |.  ..|.  ..|| || ||.||||..|.|.|.|    . 
nfgwkDygvasleriLdivkvvafalqeg..kvav.hChaGlGrtGvliacylvyakrlta
PTPc_DSPc_SM00012 87-171 3.7e-10 35.3 In-house 7-95 (105) alignment 
Range on Protein: 87-171
Range on HMM: 7-95/105.0
YYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDS-KNIAVIHCKAGKGRTGLMICCWLMYCGMWKNT--EDSLRFYAALRTYNQKGVTIPSQ
|.   ||..|.  . |  ..|.|. .... . ..  |.||.|| |||| ...  .... ..|.|   | ...  .||.. .. |.   |
ytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq
PTPlike_phytase Inositol hexakisphosphate 89-141 2.2e-08 28.8 Pfam-A 99-148 (149) alignment 
Range on Protein: 89-141
Range on HMM: 99-148/149.0
PFDDHNAPQFEMIDAFCRDVDAWMKedsKNIAVIHCKAGKGRTGLMICCWLMY
|  |..||..|..||| | .   ..   ..  |..|.||.||| ... .  ..
pitdeqapeeedvDafvrlikslpr...dtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 89-141 2.2e-08 28.8 In-house 99-148 (149) alignment 
Range on Protein: 89-141
Range on HMM: 99-148/149.0
PFDDHNAPQFEMIDAFCRDVDAWMKedsKNIAVIHCKAGKGRTGLMICCWLMY
|  |..||..|..||| | .   ..   ..  |..|.||.||| ... .  ..
pitdeqapeeedvDafvrlikslpr...dtalvfnCqaGrgRTTtamviadLl
subfamily_PTPMT1_pd Subfamily PTPMT1 90-158 3.2e-08 28.2 In-house 81-147 (171) alignment 
Range on Protein: 90-158
Range on HMM: 81-147/171.0
FDDHN-APQFEMIDAFCRDVDAWMKedSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNtEDSLRFYAAL
  |.  ||..| .    . ..  ..  ...   .|||||.||.. .. |.||.   ..  |. |.. .. 
tvDfteapdleklekgvefiekvas..kgkrvYvHCkaGrgRsatlvacylmkkeklsp.eeAlkalkkk
subfamily_DSP23_pd Subfamily DSP23 90-140 2.5e-07 25.4 In-house 59-107 (148) alignment 
Range on Protein: 90-140
Range on HMM: 59-107/148.0
FDDHNAPQFEMIDAFCRDVDAwmkEDSKNI-AVIHCKAGKGRTGLMICCWLM
 ||.  |  | .. | | |.     ..||    .||  |.|||| |. |.|.
iddyhppaleqvvefvrvvee...aeekneavsvhcllgrgrtgtmlacylv
PTPc_motif_SM00404 90-146 1e-06 23.7 In-house 54-109 (140) alignment 
Range on Protein: 90-146
Range on HMM: 54-109/140.0
FDD-HNAPQFEMIDAFCRDVDAWmkEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWK
 || .... .. .|.  . ...   |...   ..||.||  |.. .|...||.   ..
lddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqls
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 90-140 5.4e-06 20.7 In-house 185-236 (318) alignment 
Range on Protein: 90-140
Range on HMM: 185-236/318.0
FDDHNAPQF--EMIDaFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLM
. |.. |.   ...| . |.|... .. .... |.|| || ||||  |    .
Wpdegvpesgaslld.lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdil
subfamily_RNGTT_pd Subfamily RNGTT 94-159 3.7e-09 30.5 In-house 90-154 (189) alignment 
Range on Protein: 94-159
Range on HMM: 90-154/189.0
NAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKnTEDSLRFYAALR
.||. | .. | . |. ..|. ....  .||. |  ||| .|...|.    |.  |.... .|  |
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws.veaavalFakaR
Y_phosphatase3 Tyrosine phosphatase family 113-146 2.2e-06 22.8 Pfam-A 122-153 (164) alignment 
Range on Protein: 113-146
Range on HMM: 122-153/164.0
KEDskNIAVIHCKAGKGRTGLMICCWLMYCGMWK
.|.  . ...||.||| |||...   |  .|. .
eee..gpvlfHCtaGKDRTGvvaalllsllgvde
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 188-404 1.4e-20 64.8 Pfam-A 1-133 (134) alignment 
Range on Protein: 188-404
Range on HMM: 1-133/134.0
YVPRNVTLKKIVLRPLP--KEINLSEVQFNISVGKNCVFnskehnmnvviskkkktvvdknkkdpkkkltkenseK----------Nidsqqqqqsqssl
| |....||.|.|...|  |  .  ....... ||..||                                    |          .             
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvf....................................kelasykdster.............

sqsqqgqsspnmqslsasgtissgsnvgtvngntlhqlggsqfslsdladgntigNDEYISFEIG-ALSLAGDIRIEFTNKQ-----DDRMFMFWVNTSF
                                                       ... . ...   | . ||...|| .|.     ....| .|.||||
.......................................................raktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsF

VQ---QLEIIPKSGLDKAHKDKnHKAFPEDFHVELTFD
..   .. ..||. ||||.||| .| |...|.||| |.
ieknqnvltlpkneLDkalkdk.dkkfsknfkvelvfe