Gene ptpA1-1 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily ptpA1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP045_AA protein Get Run
DdisP045_AA_79-473 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 74-476 2.2e-88 291.9 In-house 21-303 (308) alignment
Range on Protein: 74-476
Range on HMM: 21-303/308.0
LVDEERIKSSIYNLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLkkiqdKEGSDYINANYIDGA---YPKQFICTQG
 ....    .. .| .. .......|||. | .   . |.| . .. | .||||..|||  |.|| |     .||||||||.|.||    .|..||.|||
vsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGeqfsiygnGNEVFGTYSVELVEVIQdpEREIITRNIRLTF--EGETRDITQYQYE
|||||..||||||||...|.|||| .. || |.||..|||. .||        | ...| ..|.|... .  . ....|...||.  .||.| .|...| 
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg........gsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhyt

GWPDHNIPDHTQPFRQLLHSITNRQnqiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglg
.||||..|...... ..|. . ...        .. ||.|||||||||||||... ...  |..                                    
nWpdhgvPpspeilldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqlek....................................

yhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTI
                                                                     ...|..| ||||||||||| .|||||.|...
..................................................................eggvdvfeavkklReqRpgmvqtpeqylflyral

LDEIYHRL
|. .. .|
leylklkl

subfamily_ptpA1_pd Subfamily ptpA1 75-492 4.6e-308 1015.5 In-house 1-418 (418) alignment
Range on Protein: 75-492
Range on HMM: 1-418/418.0
VDEERIKSSIYNLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPKQFICTQGPLPN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vdeerikssiynlknhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpn

TIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQFSIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhn

IPDHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDATPIDQVVDPFTHLPITEYQSDNLDLKGLGYHFKSS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkss

IYNSNGINNNNNNNLNNNNNINNNSNGSNNTPQTEPNNEEDDDDAAESDLKYAIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYH
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
iynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridfnlfsivlklreqrpgmvqqleqylfcyktildeiyh

RLNCKLGFSLPHVNNINN
||||||||||||||||||
rlncklgfslphvnninn

subfamily_PTPN6_pd Subfamily PTPN6 80-332 5.2e-66 217.7 In-house 9-256 (306) alignment
Range on Protein: 80-332
Range on HMM: 9-256/306.0
IKSSIYNLKNHIKCIH--KIKEEFRLL--EESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkIQDKEGSDYINANYIDGAYP---KQFICTQGPL
|.. . .|... . ..   ..|||  |  ||.    . .||.|..|..|||| ||||..|||| ||  ..  ||||||||||... .   |..| ||| |
ieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl

PNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygNGNEVFGTYSVELVEViqDPEREIITRNIRL---TFEGETRDITQYQYEG
..|..|||||||.. .|.|||. .| |  . || ||||..          . .| .|..||. |.   .  .. | |....   ....|.|.. ||... 
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPde..........eekeeyGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfks

WPDHNIPDHTQPFRQLLHSITNRQNQIIPSsdRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
||||..| ... . ..|. ....|...  .  .. ||.||||||.||||||    |..|.. .
WPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliek

subfamily_eak_pd Subfamily eak 83-328 4.2e-16 53.2 In-house 20-261 (332) alignment
Range on Protein: 83-328
Range on HMM: 20-261/332.0
SIYN-LKNHIKCIHKIKEEFRLLEESvgpsetsEGDKKHNTSKNrYTNILPVNHTRVQLKKIQdKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFW
 |.| ....|. .... .  ||| .|       |...  .  .|   .|.| ..  |.|   | ..   ||||  .. .   ...| |  .  . .  ||
hiwnrinqrinivadlddyqrllsis.......etarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafw

RMVWENRCRIIVMLSRESENCRIKCDRYWPEQiGGEQFSiygngnevFGTYSVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQ
.|| |..   ||.|  . |.   | |.|.|.. . |...        || . ||  | ..     . ||.. |.   ||  .  |.. || . ..|   .
qmvleqkspaivqlledvelkleksdkyfpdk.treelk........fGildverkefvkr..niletrllelskGnethrvlhykvfGwtettlpkyed

--PFRQLLHS-----ITNRQNQIIPSSDR--------NVPIIvHCSAGVGRTGTFCTAVIMMK
   .|. .       . . ..... |  .        . |||  .. |  |.|.|    ....
flalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsarGsaraGvfvvidllir

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 84-331 2.4e-69 228.8 In-house 11-241 (318) alignment
Range on Protein: 84-331
Range on HMM: 11-241/318.0
IYNLKNhiKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRM
. .|..  .   ...||.  |. |   . . .  .. |  ||||.|||. .||||.|......|||||||||||||    |..| .|.|||.|| |||||
vrrlre..sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrm

VWENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTqpf
|||  ...||||..|.|....|..||||..           | . .|.  ||| | ..  .  . . ... | | |.|.. ||.|  |||...|...   
vWeqnsavivmltqeeergkakvhryWPsk...........gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...

RQLLHSItnRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
 .||. .  || . .  .  . ||.|||||||||||.|..  |..... 
aslldlv..rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik

0036941 (Phosphotyrosine protein) phosphatases II 85-478 5.2e-85 280.6 In-house 3-283 (297) alignment
Range on Protein: 85-478
Range on HMM: 3-283/297.0
YNLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLkkiqDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMV
..|............||. | .   . ..| . .. | .||||..||| .||||.|    |.||||||||.|.|| . ...||.||||||||..||||||
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv

WENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQFSiygngnevfGTYSVELVEVIQDPEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQP
||.....||||... |. |.||..|||. .|...           | ..|.|..| .... ....|....|.  .||.| .|...| |||||..|.....
weqnvtvIvmltelvelgrekcaqywpleegeslty.........gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespas

FRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH--YFKQLDatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsn
. .... . ......     .. |..|||||||||.|||..| .|.  |..  . ...|                                         
lldfielvrkvlkll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd.........................................

ginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridfnLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLNC
                                                            ....|.||||||||.||.||||.|.| ..|. ....|..
............................................................ileavkklReqRpgavqtleqyrflyeallellkkkltk

0039614 (Phosphotyrosine protein) phosphatases II 85-473 4.7e-83 274.4 In-house 22-290 (297) alignment
Range on Protein: 85-473
Range on HMM: 22-290/297.0
YNLKNHIKCIHKIKEEFRLLEESVGPseTSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDK-EGSDYINANYIDGAY--PKQFICTQGPLPNTIADFWR
..|... ........||  | . . .  .|.. .. | .||||..||| .|.||.|| . .  ..||||||.|.|| .  ...||.||||||.|..||||
llllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MVWENRCRIIVMLSRESENCRiKCDRYWPEQIGgeqfsiygngneVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQP
||||.....|||| .. |. | ||..||||  |            ..|...|.|..|..  .  ...|....| .||.| .|..|| |||||..|.... 
mvweqgvtvivmLtklvelgr.kcaqywpeegg............tygdftvtllkveh..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslel

FRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsngi
. ..|. . .....     ... |..|||||||||||||..| .|.  |.                                                  
lleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqle..................................................

nnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
                                                    .. .......| .|||||||.|| ..|| |.|. .|. . 
....................................................keggvdvleavkelreqRpgavqtpsqyrflydallellk

0045450 (Phosphotyrosine protein) phosphatases II 85-470 1.4e-78 260.1 In-house 17-302 (307) alignment
Range on Protein: 85-470
Range on HMM: 17-302/307.0
YNLKNHIKCIHKIKEEFRLLEESVG--PSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDK-EGSDYINANYI--------DGA-YPKQFICTQGPL
. |............||. | .     . |.|.. ...| .||||..||| .||||.|. .... |.||||||.|.        ||   ...||.|||||
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

PNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiggEQFSIYGNgnevfgtYSVELVEVIQdpEREIITRNIRLT---FEGETRDITQYQYEG
|.|..|||||.||.....||||... |. |.||..|||.    ...  |||       . |.|... .  . ... |....|   ..||.| .|...| |
petvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygn.......ftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytg

WPDHNIPDHTQPFRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYfkqldatpidqvvdpfthlpiteyqsdnldlkglgy
||||..|...... .... . . ...     ... |..|||||||||||||..| .|.. |..                                     
wpdhgvppsfeelldfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqleke....................................

hfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsrI---DFNLFSIVLKLREQRPGMVQQLEQYLFCYK
                                                                      |..|...| .|||||||.|| .||| |.|.
..................................................................gtlldvdlleavkllreqRpgavqnpeqyrflye

TILD
 .|.
alle

subfamily_PTPRD_pd Subfamily PTPRD 85-332 2.8e-78 259.0 In-house 8-243 (564) alignment
Range on Protein: 85-332
Range on HMM: 8-243/564.0
YNLKNHIKCIH-----KIKEEFRLLEESvGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIAD
..||.|.. ..     |..||.. .||.   ..... .|..| .|||| ||.. .|.|| |.|.. .||||||||..|||   .|..| |||||..||.|
aelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetied

FWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiGGeqfsiygngnEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDH
|||||||.....||||.. .|. . ||..||||. |           | .| . |.|.|  .  . || | ... . . |.| ..|...  ||||..|..
FWRmvweqnsstiVmltkleEkgkvkchkYWPek.gt..........etygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

TQPFRQLLHSITNRQnQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
.... .|.. ... . .     . . ||.|||||||||||||..  .|.... .
atslLdlirkvraln.e.....pdagPivVhCSaGVGRTGtfividamlerike

0047943 (Phosphotyrosine protein) phosphatases II 86-470 3.7e-83 274.4 In-house 3-270 (273) alignment
Range on Protein: 86-470
Range on HMM: 3-270/273.0
NLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLkkiqDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVW
.| .. .......|||.|| .   . ..| . ...| .||||..|||..|.|| |    . .|||||||.|.||  ....||.||||||||..|||||||
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvw

ENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiyGN-GNEVFGTYSVELVEVIQdpEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQP
|...|.|||| .. |. |.||..|||.          |.   ...| ..|.|... .  .  ...|...||.   ||.| .|...| |||||..|.....
eqnvrviVmLtelvelgrekcaqYwple.........ggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppsles

FRQLLHSITNRQNQIIPSsdrnVPIIVHCSAGVGRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsngi
. .... . . ..... .     |..|||||||||||||... ...  | .                                                 
llefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlek.................................................

nnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
                                                     .  ......| .||.||||||| .|||.|.|...|.
.....................................................eggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_PTPRN_pd Subfamily PTPRN 87-344 9.2e-47 154.2 In-house 21-266 (297) alignment
Range on Protein: 87-344
Range on HMM: 21-266/297.0
LKNHIKCIHKIKEEFRLLEES-VGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPKQ--FICTQGPLPNTIADFWRMV
|..|.|  .....|.  | .    || .. .....| .|||....|| .|.||.||. ...| ||||||  |    |..  .| |||||..|.||||.||
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmv

WENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVE-VIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPF
||. . .||.|.| .|.   .|.||||..           |.||.. | |.||   |   .  . .  ..     ||| .||. .  ||....|  ....
weqGvvvivnltrleeegvkqckrywpde...........GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksl

RQLlhsiTNRQNQIIPSsdRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDAT-PIDQ
 ..      . |.      |  ||.||||.|.||||...   .....| .  |..| .  .. 
lef....rrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatleh

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 87-169 9.7e-10 32.5 In-house 15-94 (95) alignment
Range on Protein: 87-169
Range on HMM: 15-94/95.0
LKNHIKCIHKIKEEFRLLEESVGPSETSeGDKKHNTSKNRYTNILPVNHTRVQLKKiqdKEGSDYINANYIDGAYPKQ-FICTQ
|. | .  ... .||. .  . | . |  |  . |  |||. ||.| . ||| |     |  |||||| ..||   |. .|..|
lemhsnsdqefdnefksismtsgapytv.gsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq

0051299 (Phosphotyrosine protein) phosphatases II 88-470 3.4e-86 284.5 In-house 16-284 (288) alignment
Range on Protein: 88-470
Range on HMM: 16-284/288.0
KNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWEN
| . .......|||. | .   . ..| . ...| .||||..||| .|.||.|. ... ||||||||.||||  ....||.||||||||..||||||||.
kllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweq

RCRIIVMLSRESENCRIKCDRYWPEqiggEQFSIYGNgnevfgtYSVELVEVIQdpEREIITRNIRLT------FEGETRDITQYQYEGWPDHNIPDHTQ
..|.|||| .. |. |.||..|||.    ... .||.       ..|.|... .  . ....|....|      ..||.| .|...| .||||..||...
nvrvIvmltklvelgrekcaqYwpl....ggsltygd.......itvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

PFRQLLHSITNRQNqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsng
.. ..|. . . ..      ... |..|||||||||||||... ...  |.                                                 
llldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqle.................................................

innnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
                                                      .  ......| .|||||||||| .|||.|.|...|.
.....................................................keggvdvleavkrlreqRpgmvqtpeqyrfvyealle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 88-330 2.7e-55 182.7 In-house 15-243 (305) alignment
Range on Protein: 88-330
Range on HMM: 15-243/305.0
KNHIKCIHKIKEEFRLLEESvgPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWEN
.....  .........| |   .. .  | |..|..|||...| . .. |..|.. .... ||||||.|.||    |..| .||||.||.|||||...| 
earvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrlivee

RCRIIVMLSRESENCRIKCDRYWPEQIGGeqfsiygngNEVFGTYSVELVEVIQDPerEIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFR
. . ||||..  |. . || .||||...          .. || .|||| .  . .  . |.|......   . |.| ..|||   |||| .|. .  . 
kvstivmltklveggkdkCrqYWpeskte.........kkefgefsvelksektas..dyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

QLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
.|.. ....|..     |..||..|||||||||||.|..  |.. .|
slikrvqkdqkk.....dkgvpllVhCsagvgRtGvfiavdialerl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 88-329 1.1e-47 157.3 In-house 13-242 (290) alignment
Range on Protein: 88-329
Range on HMM: 13-242/290.0
KNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEG--SDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVW
..|.|  .. ...|  |. .  . ..  |  . |  .||..||.. .  |. |..|....    .|||| ||.|    ||.| ||||..||..|||...|
nghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

ENRCRIIVMLSRESENCRIKCDRYWPEQigGeqfsiygngNEVFGTYSVELVEVIQDPerEIITRNIRLTFE---GETRDITQYQYEGWPDHNIPDHTQP
.... |||||  . |. . ||  |||..  .         .. .| .|..|..  .    |.|.|..... .   |... .||||   |...    ..| 
qekvtiivmltniieegkvkCqqYWpds..d.........tkaygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

FRQLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
  .... ... | .     . | .|.||||..|||...||.| . ..|
illvieemyktqrk.....rgntsivvHCSdtvgrsavfcaaattink

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 88-329 1.6e-46 153.6 In-house 13-237 (287) alignment
Range on Protein: 88-329
Range on HMM: 13-237/287.0
KNHIKCIHKIKEEFRLLEE-SVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqdKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWE
|.| |     |. | .||. .  . |   .  ..|  |||.|.||. .  || ||    .|  ||||| .|||    |.|| ...|. ||. .||.....
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWklidd

NRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEviQDPEREIITRNIRLTFEG---ETRDITQYQYEGWPDHN-IPDHTQP
..  .||||..| || . .| .||||.            . |.| |..||..  .. . . | |..... ..   ... ..|||.  |...  ....   
rnvtaivmlcqekendeevcyqyWpee...........ksvvlGeynielln..eevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

FRQLlHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
. .. .     | .       | .|.||||..|||...|| | . ..|
llvi.eemyktqrk.....rgntsivvhCsdtvGrsamfcaaattink

0043336 (Phosphotyrosine protein) phosphatases II 89-333 3.9e-72 238.3 In-house 14-240 (278) alignment
Range on Protein: 89-333
Range on HMM: 14-240/278.0
NHIKCIHKIKEEFRLLEESVGpSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENR
 . .. .....||  | .     ..| . ...| .||||..||| .|.||.|. ..  ..||||||.|.||   |..||.||||||.|..||||||||..
lllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

CRIIVMLSRESENCRIKCDRYWPeqiggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQL
...|||| .. |. |.||..|||            .| ...|...|.|.....  .  ...|....|   .||.| .|.|.| |||||..|...... ..
vttivmLtelvelgrvkcaqYwp............ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

LHSITNRQNqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
|. . ....      |.| |..|||||||||||||... ...  |...
lkavreale......dsngpvlVHCsaGvgRTGtfialyllleqleke

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 89-330 1.4e-66 219.8 In-house 12-243 (319) alignment
Range on Protein: 89-330
Range on HMM: 12-243/319.0
NHI-----KCIHKIKEEFRLLEESVGPsETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRM
...     .  .....||.||.|.|   .... .|..| .||||.|||....|||.|......||||||||..|||    ..|| ||.|| ||| |||||
erlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

VWENRCRIIVMLSRESENCRIKCDRYWPEQiggeQFSIYgngnevfGTYSVELVEVIQdpEREIITRNIR---LTFEGETRDITQYQYEGWPDHNIPDHT
|||... |.|||.. .|. ..|. .||||.    .|  |       | . |.| |  .    ..| |..    .. | |||.....||. ||||..|...
vWeeessivvmltklveklkvklkkywpee....nfeey.......Grlivtleeeee..ledyiirklklnkkssevetRevkhfqyteWpdhdvPeka

QPFRQLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
.   .||. | . ...       . ||.|||||||||||||..  .|. ..
tslldllkrirksrek.....tqsgPivvhCsaGvGRtGtfivldamlerv

subfamily_PTPRK_pd Subfamily PTPRK 89-329 2.3e-56 185.9 In-house 11-236 (314) alignment
Range on Protein: 89-329
Range on HMM: 11-236/314.0
NHIKCIHK-----IKEEFRLLEESvgpseTSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRM
..|.....     .|||.  | |           |..| .|||...||. ...||.|. |..   ||||||..||.   |..|| |||||..|..||||.
qsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

VWENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygngNEVFGTYSVELVEViqDPEREIITRNIRLTF----EGETRDITQYQYEGWPDHNIPDH
|....|  ||||.   |. |.|| .||||.             ||.|   |||||.  ... |...|  |..       |.| . |.|. |||||..| .
vydencasivmltelvevgrvkClkyWPed............tevygdikvelvet..ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs

TQPFRQLLHSITNRQNQiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMKK
 . . .|.. . . |..      .. .|.|||||| ||||||..  |..  
atgllklvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldm

0040438 (Phosphotyrosine protein) phosphatases II 92-486 1e-83 276.6 In-house 15-290 (317) alignment
Range on Protein: 92-486
Range on HMM: 15-290/317.0
KCIHKIKEEFRLLEESVGPsETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRI
.  ....|||. | .   . ..|.. .. | .||||..|||  |.||.|. ..  ..||||||.|.|| . ...||.||||||||..||||||||.....
sdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLSRESENCRIKCDRYWPEqiggEQFSIYgngnevfGTYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHS
|||| .. |. |.||..|||.    ...  |       |...|.|.....  . .|. |.....   ..|.| .|...| |||||..|...... ..|. 
ivmLteleelgrekcaqYwpl....getlty.......gdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

ITNRQNqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnn
. . ..      |.. |..|||||||||||||..| .|.  |.                                                         
vreale......dpggpvlVHCsaGvgRtGtfiaaylmleqle.........................................................

lnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLNCKLGFSLPH
                                              . .......| .|||||||.|| .||| |.|. .|. ....|...   .|..
.............................................keggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselkl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 92-330 1.7e-55 183.3 In-house 24-250 (298) alignment
Range on Protein: 92-330
Range on HMM: 24-250/298.0
KCIHKIKEEFRLLEESV---GPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENR
| . . ..||. |..        |.. . |..| .||||..|......|| |.|....| |||||| .....   . || ||.||..|..||||||.|. 
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteed

CRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLH
   ||||    |  ..|. .|||..           |.| .|. .|.| .  .  . .. . ..  . | ..| . | ..  |||. .| ...   .||.
igtiVmltnleeldktkyhkywPde...........gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

SITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
 .   |.|       |.|.||.|||||||.|||.    .. ..
kvrasqqq.....agnkpvivqCsaGvgRsGtfiaidsvlerv

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 92-330 1e-45 151.1 In-house 13-236 (307) alignment
Range on Protein: 92-330
Range on HMM: 13-236/307.0
KCIHKIKEEFRLLEESVgPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRI
| ......||| | .   |   .    . || ||||...  ....|. .|   |   |||| |||.  |  ||.|||.|||| ||. .|| |. ...   
kgvqalvdefrvlakkt.pegvtveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMLSRESENCRIKCDRYWPEQIGgeQFSIYGNGNEVFGTYSVELVEVIQDpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIT
..|| .  | ..|||..||| . |  |  ..|. ..      .   ..  | |  |   .... . ...| |...|.| |||. .|.       ||... 
vimlckvielakikceqywpleeg..qklvfgeapntisvanlgakklapd.edlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr

NRQNqiipssdrnvPIIVHCSAGVGRTGTFCTAVIMMKKL
  .|          |..|||||||||.||  .  ... |.
ydtn..........pvvvhcsaGvGrsGtivaislvqdkm

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 93-331 3.4e-34 112.9 In-house 22-249 (305) alignment
Range on Protein: 93-331
Range on HMM: 22-249/305.0
CIHKIKEEFRLLEESVGPSETSE-----GDKKHNTSKNRYTNILPVNHTRVQLKKIQdkeGSDYINANYIDGAY--PKQFICTQGPLPNTIADFWRMVWE
 ..|..|||| |     |  |          . . .||||...   ... |.|.| .    |||| |||.       |.|||.|||| .|| .|| || .
gvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviq

NRCRIIVMLSRESENCRIKCDRYWPEQIGgEQFSIYGN--GNEVFGTYSVElveviQDPEREIITrnIRLTFE-GETRDITQYQYEGWPDHNIPDHTQPF
|.   |||| .  |  ..|| .|||   | |. .. .    ..| |.  .|     .|.| .| .  ..||.  ...  . . |.  |||  .|      
nkveqivmlcktvelgklkcaqywpaaqg.eklelksgivvenvsgskpme.....rdaeiqitl..lnltysgdqkmsvrhlqwtewpdrgvppcklts

RQLLHSITNrqnqiipsSdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
 .|| .|          |  .|||.||||||.|||||  .   ...|. 
lellsairg........s..kvpivvhcsagigrtgtivaieyilekia

subfamily_egg_pd Subfamily egg 93-327 1e-25 85.1 In-house 12-225 (307) alignment
Range on Protein: 93-327
Range on HMM: 12-225/307.0
CIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRII
 . ...  . .|||||      .  .. |  | |   .   . .||.|.  . .   |.| ||...|     .||..| || ||  ||||||...... |
ivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLSRESENcrIKCDRYWPEQIGGEQfsiygngNEVFGTYSVELVEVIQDPEREIITRNIRLtfEGETRDITQYQYEGWPDHNIPDHTQPFRQLlHSItn
|||.   |.   .|. |||                | |.. .| ..| . ..      ...|   |  ..    ..  .  .|  |   |.| |   .  
vmltsrkes..erceyywpkaesdsl.......vtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqgdvnnssdvysplrvl.rkl..

RQNqiipssdrNVPIIVHCSAGVGRTGTFCTAVIMM
|.           |..|..  || ...|. .. | .
rnl........skpvvvqdilGvskaatlvaieial

subfamily_PTPRG_pd Subfamily PTPRG 94-332 1.5e-58 193.4 In-house 18-249 (563) alignment
Range on Protein: 94-332
Range on HMM: 18-249/563.0
IHKIKEEFRLLEESVGPS--ETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGS-DYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCR
 ....|||  |.. . ..  ...  .|..|  ||||.||......||.|... .|... |||||||||| .  |.|| |||||..|. |||||.||..  
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

IIVMLSRESENCRIKCDRYWPE--QIGGEQFSIYGNGNEVFGTYSVElveviqdperEIITRNIRLTFEG---ETRDITQYQYEGWPDHNIPDHTQPfrq
||||..   |. | |||.|||.   .  .....    .||. .|.|.          ... .|..|  .    . . ..||.|  ||||. |.|. |   
iivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr..........tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp...

LLHSITNRqnqIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
 |  .  .        .   ||.||||||||||||..    ..|.. .
vLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq

subfamily_PTPRA_pd Subfamily PTPRA 94-330 4.7e-53 175.2 In-house 31-255 (330) alignment
Range on Protein: 94-330
Range on HMM: 31-255/330.0
IHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIV
 ....|||  |  .   .     .|. |  |||. |||| ...|| | ... .| |||||| .|||   | .|| .|||. .|. |||||.|| .   ||
nklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativ

MLSRESENCRIKCDRYWPEQigGeqFSIYGNGnevfgTYSVELVEVIQDP-EREII-TRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIT
||.   |  . || .|||..  |     |||      . .|| ..|..|   |... ..    | | ..| ..|. ...|||  .| ...   .||. . 
mltelkerkeekcaqywPde..G..lvtyGni.....rvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

NRQNQiipssDRNvPIIVHCSAGVGRTGTFCTAVIMMKKL
. ..|       . ||.|||||||||||||..   .....
klnqq.....sag.pivvhcsaGvGrtGtfivldavlerv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 94-325 4.6e-40 132.2 In-house 14-248 (301) alignment
Range on Protein: 94-325
Range on HMM: 14-248/301.0
IHKIKEEFRLLEESVgPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQ--DKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRI
 .|..|... |.|   . ... | ...|.  ||. || .... |. ||. .  |.   .||||.||||    |.|| .|||. .|..||||..|...   
snkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLSRESENCRIKCDRYWPEQI----GGEQFSIYGNGNEVFGTYSVELVEV-IQDPER-EIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQ
|||.  . |. . || .|||.         .|..  . . |.  . .  . | |||      | |... . . ...|..|.|   ||.. .    .   |
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

LLHSITNRQNQIipssdRNVPIIVHCSAGVGRTGTFCTAVI
 .. .  ||..|        |..||||..|.|.|..|.  |
viddvihrqqki.....gggpvvVHCSdtVsrsGvYcsvsi

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 94-333 1.6e-32 107.3 In-house 26-253 (310) alignment
Range on Protein: 94-333
Range on HMM: 26-253/310.0
IHKIKEEFRLLEESVGPSETSEGDKKhNTSKNRYTNILPVNHTRVQLKkIQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIV
|. .  ..| |.    .| | |  || .  ||||....  . .||.|| |.     ||| |||.   | .  |||.||||  || |||||....|.  |.
ieglvkqyrkldakqdssltyeaykk.ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLSRESENCRIKCDRYWPEQIGGEQFSIYGNGN--EVFGTYSVELVEVIQDPEREIITRNiRLTFegETRDITQYQYEGWPDHNIPDHTqpfrqlLHSIT
.| . .|. | ||  |||     | .      |  |    . .  . |   |.   .  .    .  .   ..  ..  |||  .||         |.. 
llckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeq.panl..kelrvslikwpnwpdrgvpdek......chtvp

NRqnqiIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
.|    . .  |  | .||||||..|... ..  . ..|||. 
qr....llaqvrhgpcvvhcsagkdrlyvvvalklkidkldrg

subfamily_PTPRB_pd Subfamily PTPRB 95-332 7.7e-72 236.8 In-house 25-247 (293) alignment
Range on Protein: 95-332
Range on HMM: 25-247/293.0
HKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
....||.  |..     ...  ... |..||||||||| .|.||.|....|..||||||||||.|   |..|| ||||||.|. ||||||||....||||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LSRESENCRIKCDRYWPEQiggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQ
| .  |. ..||..|||..          . . ..|  .|.||.  .   .. ..|..... | |.|...||..  ||||..|..|... .... . ...
ltqlvekgkvkCeeYWPad..........eepvlyGdikvtlvaeee..ledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

NQiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
..    . .. ||.||||||||||||| .   .......
ek....taskrPivvhCsaGvGRtGtfialdrllqaiee

subfamily_PTPN9_pd Subfamily PTPN9 95-333 1.1e-61 203.5 In-house 16-253 (297) alignment
Range on Protein: 95-333
Range on HMM: 16-253/297.0
HKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
. ...|.  . .     .     .. | .|||||..| ...|||.|.|....| |||||||..||   .| || |||||..|. ||||||||.....|||
rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LSRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQ
  |  |. |.|| .|||..          .  . || .||. ||| .  . .. . .|. . ..|.| .| .|. .|||. .|. .. . ..|. . ..|
ttrvvergrlkcgqyWplee.........essaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

NQIIPS-------SDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
 ... .         .. ||.||||||.||||||.|  | ...|.. 
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleev

subfamily_Ptp69D_pd Subfamily Ptp69D 95-331 1.9e-59 196.3 In-house 22-247 (307) alignment
Range on Protein: 95-331
Range on HMM: 22-247/307.0
HKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
. ...|.. ||..  . .|. ..|| |. |||| .| . ..|||.||||. || ||||||..| |    |.||. |.|. .|| |||||..|    .|||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LSRESENCRIKCDRYWPEQiggeQFSIYGngnevfgTYSVELVEviQDPEREIITRNIRLTFEG-------ETRDITQYQYEGWPDHNIPDHTQPFRQLL
|| ..|  | ||..|||..    .   ||          |.||.  ..   . | |.. ..  .       ..| ..||.| ||.| ..|....   .|.
lsnlteknrkkcakYWpie....devqyg.......dilvklvs..eekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

HSITNRQNQIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. . . ...       . ||.|||||||||.|.| .  .....| 
eqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlk

DSPc_SM00195 96-472 5.1e-116 382.0 In-house 1-262 (263) alignment
Range on Protein: 96-472
Range on HMM: 1-262/263.0
KIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
|.||||. ||||  |.||.|..||.|.|||||.||||..||||.|||...||||||||||||.|| ..|..|.||||||.|..||||||||....|||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQDPeREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNR
..|.||...||||||||..         .|.|.||..||.||||.... .|||.|...||.||  |||..|||||..||||..||.|.....||......
teeeengkekcdrywpees.........ggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkks

QNQIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnn
....      ..||.|||||||||||||.|. |...||....|                                                         
ksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk.........................................................

nninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
                                             ...|.|| .||.|||||||.||||||.|..||. |
.............................................vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 96-472 5.1e-116 382.0 In-house 1-262 (263) alignment
Range on Protein: 96-472
Range on HMM: 1-262/263.0
KIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
|.||||. ||||  |.||.|..||.|.|||||.||||..||||.|||...||||||||||||.|| ..|..|.||||||.|..||||||||....|||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQDPeREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNR
..|.||...||||||||..         .|.|.||..||.||||.... .|||.|...||.||  |||..|||||..||||..||.|.....||......
teeeengkekcdrywpees.........ggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkks

QNQIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnn
....      ..||.|||||||||||||.|. |...||....|                                                         
ksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk.........................................................

nninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
                                             ...|.|| .||.|||||||.||||||.|..||. |
.............................................vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 96-332 1e-63 210.1 In-house 22-241 (288) alignment
Range on Protein: 96-332
Range on HMM: 22-241/288.0
KIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVML
 ..||.. | .    .... | . .| .|||| ||||....||.||| ....|.|||||.||||    |..|.|||||..|. |||..|.||.   ||||
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

SRESENCRIKCDRYWPEQiggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
.   |. . ||..|||..          . .. .|   |.|||. .  . ....|.. |  ... ..|||||| .||||..|. ..|. .||. . . ..
telveggktkCeeYWPda..........dkpknyGsvtvtlveske..ledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

QIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
.         |||||||||||||||| ..  .......
ad......tgpiivhCsaGvGrtgtFialdalidavee

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 96-333 3.2e-55 182.7 In-house 35-254 (319) alignment
Range on Protein: 96-333
Range on HMM: 35-254/319.0
KIKEEFRLL-EESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVM
|.. ||| . . .|  .. .  . ..|  |||..|||. ....|.|.... .|.|||||| ...|   ....| .||||.||.||||||.|| .|  ||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LSresencRIKCDRYWPEQIGGEqfsiYGNGNevfgtYSVELVEVIQDpereIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIt
|.      . || .||| .|  .    .....      .|..||  ..     . |.|.|.    | . |.|||. . ||||.  ||.. .. .|.. . 
lt......kdkcsqywplkivik....eerfk.....vkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv.

nrqNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
   . .    . . .|.|||||||||||.. .  ........ 
...rhltskenhranivvhcsaGvGrtGvyivldvlldrmkee

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 96-331 2e-47 156.4 In-house 11-238 (287) alignment
Range on Protein: 96-331
Range on HMM: 11-238/287.0
KIKEEF-RLLEESVGPSE-TSEGDKKHNTSKNRYTNILPVNHTRVQLKKiQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIV
....|. .| |.| . .    . ..  ...||||...||...||| | . . . |||||||||. .    ..||..|||.. |. ||||.|.|.|   ..
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MLSRESENCRIKCDRYWPEQiggEQFSiygngneVFGTYSVELVE-VIQDPEreIITRNIRLTfEGETRD---ITQYQYEGWPDHNIPDHTQPFRQLLHS
...|| |..| || .||||.   |.           | ||| |..  |..||    .| .||  . |||.   . |...  |||. ..  .  . ..  .
tmtreveearlkcykywPer...evPm.......rvGGysvvlldydikePe..ygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvld

ITNRqNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. ..  ..  ...   |..||...|.||.|.. . ......| 
vkqh.ielardasevGPlvvhddvGiGrsGillatlvlvsrle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 96-330 1.6e-32 107.6 In-house 7-219 (267) alignment
Range on Protein: 96-330
Range on HMM: 7-219/267.0
KIKEEFRLLEESVGPSET-SEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKegsdYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVM
.|..|| |...    | | |    ..|  .||. . || ..||| |.. ..     |||| |..| . | .|| ||.|| |||.||. .. .... .||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LSRESENcRIKcdRYWPEQIGgeQFSIYgngNEVFGTYSVElvevIQDPEREIITRNIRLTFEGeTRDITQYQYEGWpdhNIPDHTQPFRQLLHSITNRq
| .  ..  |.  ..|| ..|  |   |   ...   .|.|     .. . .||| ....  |  ....| | |. |   ||    .|. . |  |  . 
ltkvftd.nir..lfwPPkmg..qakky...qdltvehsle....keendyqiitlelkfknes.ahnvtlyyykkw...nintnnkpylkplfgilak.

NQIipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
||.    . | |..|.||.||||.||| ..  .....
nql...engnrPlvvacsdGvGrsGtflvidsqlera

0046845 (Phosphotyrosine protein) phosphatases II 97-475 3.5e-83 274.6 In-house 2-277 (284) alignment
Range on Protein: 97-475
Range on HMM: 2-277/284.0
IKEEFRLLEESVGPS--ETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDK-EGSDYINANYIDG------AYPKQFICTQGPLPNTIADFWRMVWENR
..|||. |   . .   ..| . ...| |||||..||| .|.|| || .... |.||||||.|.||       ..|.||.||||||||..||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CRIIVMLSRESENCRIKCDRYWPEQiGGEQFSiygngnevfGTYSVELVEVIQdpEREIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQ
.|.|||| .. || |.||..|||.  |. .           | ..|.|... .  .  ...|...||.   .||.| .|...| .||||..|...... .
vrvIVmltelvengrekcaqYwple.gevlty.........gdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlle

LLHSITNRQNQiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnn
.|. . . ...    .... ||.|||||||||||||... .... |..                                                    
flrlvrellen....lpgggpivVHCsaGvgRtGtfialdllleqleke...................................................

nnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkyNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
                                                .  . ......| .||||||||||.||||.|.|...|. ....
................................................glllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0045098 (Phosphotyrosine protein) phosphatases II 97-335 3.7e-69 228.5 In-house 9-238 (278) alignment
Range on Protein: 97-335
Range on HMM: 9-238/278.0
IKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQlkkiqdkegsDYINANYIDGAyPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSR
.. ||  |     ||| ... .  | .||||..|||..|.||           |||||.||||  ||.||.||||||.|.||||||.||.....|||| .
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmlte

ESENCRIKCDRYWPEqiggEQFSIYgngnevfGTYSVELVEVIQDPEREIITRNIRLT----FEGETRDITQYQYEGWPDHNIPDHT--QPFRQLLHSIT
. |. |.||..||||    ... .|       | ..|.|... . ..  ..| ... .     ..|.| .|...| .||||..|...  ..| .||  | 
lvelgrekcaqywpe....ggslty.......gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

NRQNQIIPS-------SDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFK
........         |.. |..||||||||||||.. | .|.. |.. . 
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd

subfamily_PTPN23_pd Subfamily PTPN23 97-477 4e-58 191.5 In-house 17-285 (288) alignment
Range on Protein: 97-477
Range on HMM: 17-285/288.0
IKEEFRLLEESVG--PSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGAYPK--QFICTQGPLPNTIADFWRMVWENRCRIIV
....|..||..      ..|    | ...|||...||| .|.||.|.. .|    ||||| .. .  |   .||.||.||..|..|||.||.|.. ..||
ldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

MLSRESENCRIKCDRYWPEQIGGEQfsIYGNgnevfgtYSVELVEVIQDPerEIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIT
||  ..|  . |.||||||. |  .   .|.       .|| | .| . .  . . |...|....  ......  |.. ||.. .|.  . . |.|. . 
mllskeelgkpkvdrYwPedkgetv..kfgd.......lsvtlksvrete..thvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

NRQNQIIPSSDRnvPIIVHCSAGVGRTGTFCTAVIMMKKLdHYFKQLDatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnln
.  ..    |.   |..|||||||||||.|.  .  ...| .  . |                                                     
sayeavqrkskt..PlvvhCsaGvgRtgvfalvyaavrel.ekgngll....................................................

nnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridfNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLN
                                                ..  .| .|||||  |||. ||. |.|. .| .. . |.
................................................diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 97-329 1.2e-54 180.3 In-house 21-236 (315) alignment
Range on Protein: 97-329
Range on HMM: 21-236/315.0
IKEEFRLLEESvGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLS
. |||. | .   ....  . .. | .|||| ||||....||.|. |.|.  |||||| || .    | .|..||||. .. ||||||....   |||..
fseefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

RESENCRIKCDRYWPEQIGGeqfSIygngneVFGTYSVELVEViqDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnq
  .|. .||| .|||.. .    |.       ||...|||...  ..  . ..|.. .    |.| .||.|...|||. .. .|  . .|.. .      
kkqegdkikcrqywPdrkad...sv......efGsikvellsl..eadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...

iipSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
      .. ...||||||||||| ....  ....
...ngkkefsllvhcsaGvGrtGvvisidevvaq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 97-324 2.7e-50 166.2 In-house 28-238 (297) alignment
Range on Protein: 97-324
Range on HMM: 28-238/297.0
IKEEFRLLEESVGPSETsEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPkQFICTQGPLPNTIADFWRMVWENRCRIIVMLSR
 .|||. | |.   ..|   .|| | .|.||.||||..  ||.|. ..|.  |||.|| .. |    ..|.|| | ..|.||||.||....  .||||. 
fseeflclpeaniqpqt.vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnd

ESENCRiKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQpFRQLLHSITNRQN
..|. . || |||...           |   ||. ||.|  | .   .  | |.. .| .    .| . |||.  |||.... . .  ..||. |.. ..
dnerdk.kcaryWsdk...........gvttfGdvsvvllsvse..reGfikrelevtkgkakarrvvkqyqfveWPdkaverkds.assllklisevrk

QIIPSSDRnvPIIVHCSAGVGRTGTFCTAV
.    ..   |..|||.||||||| ..|  
dfsqnaeg..PllvhclaGvGrtgvlltid

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 97-329 2e-46 153.6 In-house 25-247 (325) alignment
Range on Protein: 97-329
Range on HMM: 25-247/325.0
IKEEFRLLEeSVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVMLS
.  || ||  |...       | .| .|||. |.......|| |.  .|.  ||||||.|.     |  |. .| ||..|| |.||.| . || ..|.| 
fahefgllp.sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvln

rESENCRIKCDRYWPEQIGGeqfsiygngNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQ
 | ..   .|  |||...|             ||.  |.|. . .  .      ... . .|||| . |.|. .|.|   . .   .  .|. . . ...
.eldlgkdrcavywpkemgk.........sktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

IIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
.   .    ||.|||||||||||.| .   ...|
vtantkastpilvhcsaGvGrtGvfislysalak

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 97-346 2.8e-39 129.4 In-house 13-240 (281) alignment
Range on Protein: 97-346
Range on HMM: 13-240/281.0
IKEEFRLLEESVgPSE-TSEGDKKHNTSKNRYTNILPVNHTRVQLKK-IQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVM
.|.||  |     ||.  .  ..  |  ||||.||  .. .|||||  . .|. .||| ||||   . |  .| ||||  .| ||||||.|..    |||
fkqefsnlpgdp.psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LSRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRq
| .  |  | ||  |.| .               |  .||.  .     .. ..|  . |..||||| ||.. .. ||| ..|. .. . ..|. |  | 
lcqfletnrekcaeyfprna.........hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.

nqiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDatpIDQVV
           | ..||||||||.||. .  | .. .  .|   |   | |.|
.........stppvihcsagvgrsgtlmaveialqsihshftlpd...ikqiv

subfamily_CG42327_pd Subfamily CG42327 97-291 7.1e-31 102.0 In-house 7-192 (319) alignment
Range on Protein: 97-291
Range on HMM: 7-192/319.0
IKEEFRLLEESVGPSEtseGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA--YPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
. |||| |   .  ..           |.|. |..|. .||| |..| |.. . |..|.|. |    | ..|..| .| .. .||||.|||.. |.|| |
vaeefrdlPqliarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivql

SRESENCRIKCDRYWPEQIGGEQFSIYGNgnevfgtYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYeGWPDHNIPDHTQPFRQLLHSITN
.  ||.   .| .|.| . .... | ||.       . | | .   . .  | |  ..   . |.|..| | |  |.. ..| . ...  .|  . .
tdlselGikvcaeylPtketldntslyGd.......ilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 98-339 1.4e-61 203.0 In-house 18-244 (281) alignment
Range on Protein: 98-339
Range on HMM: 18-244/281.0
KEEFRLLEEsVGPSETSEGDK-KHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLS
.||.. |.. .| ..|..  | ..|. ||||.||   ..|||.... .... .||||||...|   .|..| ||||.|.....||.||||.. ..|||. 
ieeyeklaa.igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

RESENCRIKCDRYWPEQIGgeqfsiygngNEVFGTYSVELVEviQDPEREIITRNIRL-TFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
|| |. ..|| ||||..            .  .|.. |. ..  .  ... |.|...| . .||||...| .|  |||| .|. |. . .  . ... ..
reieagklkChrYWPddns..........elkygdvtvksta..eeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklte

qiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDA
     .....|...|||||||||||. .   ..|....  ..|| 
.....kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldv

subfamily_PTPN13_pd Subfamily PTPN13 98-329 4e-53 175.4 In-house 14-228 (273) alignment
Range on Protein: 98-329
Range on HMM: 14-228/273.0
KEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqdKEGSdYINANYIDG---AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
.|||. |.|     ....| ||.|..|||| |.||...|||.|.    .||. ||||..|         ..| .|||||.|..|||.|||| ....|.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

SRESENCRIKCDRYWPEQIGgEQFsiygngnEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
. | |. ..||.|||||. . ..         | . . |||..| .  .  . . ... .  ||.|.... ..  ||||..| ..... |..  . . |.
tlekekgkvkchrywPeskn.kkl.......kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMKK
        . ||.||||||.||.||. |  ...  
.......dagPivvhcsaGiGrsGtlitidvvlgl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 98-160 1.4e-10 35.2 In-house 16-77 (244) alignment
Range on Protein: 98-160
Range on HMM: 16-77/244.0
KEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKiQDKEGSDYINANYIDGA
||||  | . .     ..     |..|||| ||||...||| |     ||||||||||||.|.
keefvglsdhtreflqtnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 99-320 9.9e-37 121.2 In-house 24-186 (392) alignment
Range on Protein: 99-320
Range on HMM: 24-186/392.0
EEFRLLEESVGpSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRE
|||. | .    .... . |. |  |||| |||| . .||.|. |.|   |||.|| ||..    | .|..||| . .. ||||||....   |.|... 
eefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl

SENCrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfE-GETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQI
 |                                                           ..| ..|...  |||...| ||  . .... .     | 
kegd......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

ipssdrNVPIIVHCSAGVGRTGTF
        |.|.||||||||||  
......thpliihcsagvgrtgvv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 99-332 2.1e-36 120.3 In-house 24-241 (439) alignment
Range on Protein: 99-332
Range on HMM: 24-241/439.0
EEFRLLEeSVGPS---ETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVML
|.|  .. |. |    ..|   .... .|||| .. . .|||| |..|     | |||||||.| | .| .| ||||  .|  ||||.|.|...  ||||
eifekin.stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

SRESENCRikcdrYWPEQiggeQFSIYGNGnEVFGTYSVELVEVIQdpeREIITRNIRLTFEGEtRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
.   |  .     ||| .    .  .||.   |     .|| . .    | .   | | | | | | . |..|  |||.|.| ..    ..|..|   ..
tnlvesyk.....ywpsd....aevcygdi.avrvdrnielpnyvi...rgfkvfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsand

qiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
     ..   |..||||||||||||  .  | ...|  
.....keeygpvvvhcsagvGrtGtiialdialeqlkl

subfamily_PTPN3_pd Subfamily PTPN3 101-328 6.3e-53 174.5 In-house 21-233 (280) alignment
Range on Protein: 101-328
Range on HMM: 21-233/280.0
FRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGAYPK-----QFICTQGPLPNTIADFWRMVWENRCRIIVMLS
|  |       ..|.  | .| ||||| .||| ..|||.||. .     |||||||..   |      ..| |||||..| .|||.||||.....|||| 
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

RESENCRIKCDRYWPEQIGGEQfsiygngnevFGTYSVELVEViqDPEREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQ
   |. |.|| .||||.    .          .|..||.. .   | ......|.. |. .   | | |.| ||  ||||..||... | ...... . .
tlverGrvkChqyWPetedele..........ygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr

nqiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMK
      | .. |..||||||.|||| . .  . . 
......sgkeePvvvhCsaGigrtGvlilletala

subfamily_PTPN14_pd Subfamily PTPN14 104-332 2.5e-51 169.5 In-house 32-258 (300) alignment
Range on Protein: 104-332
Range on HMM: 32-258/300.0
LEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKeGSDYINANYID---GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESEN
. .    ...| .  . |..|||. ..|| ...||.|.  ...  ..||||  |    |.  ...| .||||..|. |||.||||.  ..|||| .| |.
ipkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

CRIKCDRYWPEQIGGEQfsiygngNEVFGTYSVElVEVIQDPeREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQPFRQLL---HSITNRQNQ
 . |. .|.|..   ..       .  || . |   .  .|    .||. ..| .   .| |..   ||  ||||..|.  ..| . |   .|. .. |.
gkeksfkyfPkleskkk.......tvefgkfkvt.tkfseds.dsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

IIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
 ..| ... |..|||||||||||   .. .... |.|
eveskeskPPvlvhCsaGvGrtGvlilsdlliatleh

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 106-329 6.9e-38 125.1 In-house 18-225 (283) alignment
Range on Protein: 106-329
Range on HMM: 18-225/283.0
ESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYID----GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENC
 || . ..     ..|  |||. .|.|..  ||.||        ||||| .|         |..| .|.|| .|. |||.||....   ||||..  |. 
lsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedl

RIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQdpEREIITRNIRLTFE---GETRDITQYQYEGWpdhnipD---HTQPFRQLLhsitnRQNQ
|||| .|||..           | | .| . | | .     ..  | ... |  .    .|  .. ||...|             .   |.     . |.
rikCsqyWPkr...........GsedyGeftvtlrkett..snsfiikelllrvnssakstlllahyqvidW......leygeqaiinslv.....kfnk

IIP--SSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
.|      .. ||.||||.|.|||..|..|.  .|.
vislqteskkgPivvhCstgiGrtavfiaasasvkd

subfamily_CG7180_pd Subfamily CG7180 108-331 1.7e-40 133.5 In-house 29-251 (296) alignment
Range on Protein: 108-331
Range on HMM: 29-251/296.0
VGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRiKCD
.   .   | .|.|  |||. ...| ...|| |.|.. .| |||||| |.|.   .|..| |..|  .|. .|||.|... .  .|.|... .  . .. 
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

RYWPEQIgGEQFSIYG---NGNEVFGTYSVELVEVIQDperEIITRNIRLTFEGETRDITQYQYEGWPD-HNIPDHTQPFRQLLHSITNRQNQIiPSSDR
 |||..   ||.         .. .       . . .     . . . .   . ||| ....|.  |.  ...|  |. . .|.. .   .... .  . 
sywpnks.keqygeifveiveekqyanlkirtfkltkk...ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpe

NVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. |..|..| |..|.| .... . . ...
egPvvvvssdGasRsGvylaidanlelve

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 108-327 5.8e-36 118.6 In-house 43-240 (290) alignment
Range on Protein: 108-327
Range on HMM: 43-240/290.0
VGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqDKEGSDYINANYIDGAYPkQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDR
|.. | .  ||  .  |||| ..   . ||| ||   |    ||. |||..|  .  || |||.| .|. |.|||| ...   ||||    |. . ||..
vqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceq

YWPEQIGgEQFsiygngneVFGTYSVELVeVIQDPEREIITRNI--RLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnqiipssdrNVP
|.||. | | .         || ..|      .|.. .|| . .  |   .|    .  ..   |||. ..  |  . ..|... .           . |
yypekeG.evl........tfGeitvlcs.eeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka..........sGp

IIVHCSAGVGRTGTFCTAVIMM
..||||||.|||||| .  . .
vvvhcsaGiGrtGtfvaievgl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 109-330 1.8e-41 137.0 In-house 21-255 (297) alignment
Range on Protein: 109-330
Range on HMM: 21-255/297.0
GPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQdkEGSDYINANYI---DGAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKC
 . . |   ..    ||||..|| .. |||.|..     ..|||||.|.   |   . ..|..|||| .|. |||..|.|.  |.|||...  |. | ||
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

DRYWPEQIGGEQFSiygngnevfGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIP---DHTQPFR----------QLLHSITN-
  |||.  .. . .         | . || .    |    .|  ...| .  |.| ..  |. .|||| .|   .  . |.           .. .. . 
apywpsvvqerlka.........gdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvem

-------RQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
       . . .     ||....|||||||||.|    . ....||
ftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilakl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 109-193 2.4e-10 34.5 In-house 25-115 (347) alignment
Range on Protein: 109-193
Range on HMM: 25-115/347.0
GPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEG-----SDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
 ||. .  . ... ||||  .   .. ||| |   . | .       |||| .|      |..| || |||.|. |||.||   .   .| 
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_PTPN1_pd Subfamily PTPN1 110-333 2.2e-49 162.8 In-house 21-231 (290) alignment
Range on Protein: 110-333
Range on HMM: 21-231/290.0
PSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRY
  .|.| ....| ..||| .. | .|.|..|.. .     |||||. ..     ...| ||||||||.. ||.||||.... .||| .  |. .||| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPEQIGgeqfsiygNGNEVFG--TYSVELVEviQDPEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSItnRQNQIIpsSDRNV
||..          . . ..   ...|.|..  .. ... . | ..|.     |||.|... |  |||  .|.  . | ..|. .  |.   .  |.   
wPqgee........ekellledtklkvklis..eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkv..resGsl..ssdvG

PIIVHCSAGVGRTGTFCTAVIMMKKLDHY
| ..|||||.||.|||| .  .. .....
pavihcsaGiGrsGtfclvdtclvliekk

subfamily_PTPN12_pd Subfamily PTPN12 111-331 1.4e-66 219.3 In-house 30-235 (290) alignment
Range on Protein: 111-331
Range on HMM: 30-235/290.0
SETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYW
 .|..|.|..|. |||| .||| ...||.|.||...|||||||||.| |.. ....| .|||||.|. |||||.|| . .|.||. || |. ..||.|||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PEQiggeqfsiyGNGNEVFGTYSVELVEViQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNqiipssDRNVPIIVH
||.         |. .  ||...|.| |  .  . ... | .......|.| ..|..|. ||||..|  ...  .|.... ..|.      . ..|..||
pee.........geeelefgefevtleee.kavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe......sedaPlvvh

CSAGVGRTGTFCTAVIMMKKLD
|||||||||| ..  .. . | 
CsaGvGrtGtiiaidyvrellk

0040439 (Phosphotyrosine protein) phosphatases II 113-333 1.2e-68 226.8 In-house 3-209 (249) alignment
Range on Protein: 113-333
Range on HMM: 3-209/249.0
TSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPE
.|.. .. | .||||..||| .|.||.|. ... ..||||||.|||| | ...||.||||||.|..|||||.||.....||||... |. |.||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

qiggEQFSIYgngnevfGTYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssDRNVPIIVH
    ...  |       |...|.|..|..  . ....|...||   .||.| ....|| .||||..|...... .... . . ....    ... |..||
....ggsley.......gdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVH

CSAGVGRTGTFCTAVIMMKKLDHY
|||||||||||..| .|.  |...
CsaGvgRtGtfiaaylmleqleke

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 113-321 1.1e-18 61.9 In-house 39-229 (303) alignment
Range on Protein: 113-321
Range on HMM: 39-229/303.0
TSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqDkegSDYINANYIDGAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQ
 |  .  .|  |||..... ..|..|.|    |   | || |.|..    |. | || ||. | ||||.|. |.. . ...|  .||  ..  |  .|..
vsknqfvknmdknrfvdvicldhskvkls...d...ssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

iggEQFSIYGNGNEVFGTYsvELVEVIQDPEREIITrnirLTfEGETR-DITQYQYEGWPDHNIPDHTQPfrQLLHSITNRQNQIIPSSDRNVPIIVhCS
   ..|  . .     | .    ||. .     ...    .. .|. .  .  ..|. ||  .|| .. |  .... | . |  .   || . .. .   
...qdflkfeersirvgef..krvelgdgwvlkvls....vs.ngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysdstptvym.sl

AGVGRTGTFC
.|.||.|||.
sgcgragtfa

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 116-331 8.2e-48 157.8 In-house 4-203 (250) alignment
Range on Protein: 116-331
Range on HMM: 4-203/250.0
GDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIkCDRYWPEqig
. | .|  ||||..|......|| |.| .  . |||||| ...|    | || |||||..|| ||||||.|.    ||||.  .|. .  . .|||    
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv...

gEQFSIYGNgnevfgtYSVELVEviQDPEREIITRNIRLTFEGETRD--ITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssdRNVPIIVHCSA
 |.  .||.         |.| .  ..   ....|.. |. . .. .  . |...  |||  .|....   .||. .   |.|.      | |.||.|||
.ekaekyGd.......vtvslls..keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.....gnaPvivqCsa

GVGRTGTFCTAVIMMKKLD
||||.|.|..   ....| 
GvgrsGafiaidavlerlk

0049772 (Phosphotyrosine protein) phosphatases II 116-331 6.5e-44 146.3 In-house 41-240 (314) alignment
Range on Protein: 116-331
Range on HMM: 41-240/314.0
GDKKHNTSKNRYTNILPVNhTRVQLkKIQDKEGSDYINANYIDGAypKQFICTQGPLPNTIADF----------WRMV--WENRCRIIVM----------
.|.  | .||||..|||.. .||.| . .. .|||||||.|.||   ..||.|||||..|. ||          ||||  .....|.|||          
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LSRESENCRIKCDRYWPEQIggeqfsiygngnevfgtysvelvEVIQDPEREiitrnirltfegeTRDITQYQYEGWPDHNIPdHTQPF
           | . ..|  . . .....                         |.. |||.              .| . .| .  .||.. |  .. |
srLdaAlgKtpllildgngneptaadlellk.......................eelydpelf.............erlgikylripvpDgsap.lledf

RQLLHSITNRqnqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
...|. | .         |.. |..|||.||.||||||..| ..||.|.
deflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmkllg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 116-159 6.7e-08 26.3 In-house 42-85 (440) alignment
Range on Protein: 116-159
Range on HMM: 42-85/440.0
GDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG
     |  |||| |||  .|.|| |....    |||||| ||.|
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

0042113 (Phosphotyrosine protein) phosphatases II 117-469 6.8e-75 246.9 In-house 5-240 (245) alignment
Range on Protein: 117-469
Range on HMM: 5-240/245.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqigg
 ...| .||||..||| .||||.|. ..  ..||||||.|.|| . ...||.||||||.|..|||||.||.....||||..| |. |.||..|||.    
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....

EQFSIYGNgnevfgtYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQiipssDRNVPIIVHCSAG
...  ||.       ..|.|... .  . ....|....|   ..|.| ...|.| .||||..||... . ..|. . . ...     |.| |..||||||
gesltygd.......ftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaG

VGRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnne
|||||||..| .|.  |..                                                                                 
vgRtGtfiaaylmleqlek.................................................................................

eddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
                     . ...|...| .||.||||.|| ..|| |.|. .|
.....................elgvsleeavkelrsqRpgavqtpsqyrflyeall

0037934 (Phosphotyrosine protein) phosphatases II 117-469 1.7e-68 226.1 In-house 6-239 (243) alignment
Range on Protein: 117-469
Range on HMM: 6-239/243.0
DKKHNTSKNRYTNILPVNHTRVQLkkiqdkEGSDYINANYIDGAypKQFICTQGPLPNTIAD----FWRMVWENRCRIIVMLSRESENCRIKCDRYWPeq
 .. | |||||..||| .|.|| |      |||||||||.|..   ...|.||||||.|..|    ||||.||.....|||| .. |. |.||..|||  
llpenlsknrysdilpydhsrvkl......egsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

iggeqfsiygnGNEVFGTYSVELVEVIQDPEreIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIIP--SSDRNVPII
           |....|...|.|... . ..  .. |...|.    ...|| ...|.| .||||..||..... ..|. ... ......    |.. |..
...........gevtygdftvtllseehldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSAGVGRTGTFCTAVIMMKKL--Dhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnnt
||||||||||||...| .|...|  |                                                                          
VHCsaGvgRtGtliaaylmllllgvd..........................................................................

pqtepnneeddddaaesdlkyaimdkynsridfnLFSIVLKLREQRPG-MVQQLEQYLFCYKTIL
                                  |...| .||||||| .|| ..|| |.|. .|
..................................leeavkllreqRpgkavqtpsqyrflyeall

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 117-333 2.1e-55 182.6 In-house 16-227 (270) alignment
Range on Protein: 117-333
Range on HMM: 16-227/270.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA--YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqig
.  ...  |||..|||  .|||.|....... . ||||||. |.   .|..|...||||.|. .||||.||.. . |||..   |. | ||.||||.   
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...

geqfsiYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQ---PFRQLLHSITNRQNQIIPSSDRNvPIIVHCS
        . .  . .  .. . . .  |.  |....||. .||.| .. ..|. |||| .| ...     .|||. . . ...    .. . |..||||
......epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcs

AGVGRTGTFCTAVIMMKKLDHY
||||||||. .  |... |.. 
aGvgRtGtlialDiavrlLeet

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 117-333 1.9e-54 180.1 In-house 21-218 (284) alignment
Range on Protein: 117-333
Range on HMM: 21-218/284.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSresencRIKCDRYWPEQIGG
. ..|  |||...||. ....|.|.... .|.|||||| .| |   ....| |||||.||.||||||.|| .|  ||.|.      . || .||| .|  
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

EqfsiYGNGNevfgtYSVELVEVIQDpereIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSItnrqNQIIPSSDRNVPIIVHCSA
.    .....      .|..||  ..     . |.|.|.    | . |.|.|. . ||||.  ||.. .. .|.. .    . .    . . .|.|||||
k....eerfk.....vkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkv....rhltskenhranivvhcsa

GVGRTGTFCTAVIMMKKLDHY
||||||.. .  ........ 
gvgrtgvyivldvlldrmkee

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 117-325 8.6e-54 177.5 In-house 39-231 (515) alignment
Range on Protein: 117-325
Range on HMM: 39-231/515.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGG
... | .|||| |||| . .||.|. |.|.  |||.|| || .    | .|..|||.. .. ||||.|....   |.|... .|. .||| .|||.. | 
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

eqfSIygngneVFGTYSVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssdrNVPIIVHCSAGVG
   |.       ||...|||| .  .   . | |..... . ..| .||.....|||. .| ||. . .|.. .   ..|.      . |.|.|||||||
...sv......kfGsikvelvsleac..tggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqy......thpliihcsaGvG

RTGTFCTAVI
||| ....  
rtGvvisids

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 117-329 8.4e-36 118.3 In-house 4-200 (239) alignment
Range on Protein: 117-329
Range on HMM: 4-200/239.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG--AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIg
 |. | .||||.||.  .|.|| |.|. .   ||||||.|.      || .|.||| .  .  |||||.|..|  .||||.   |  . || .|||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

geqfSIYGNGNEvfgtySVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnQIIPSSdrnVPIIVHCSAGV
    | | |        ..   ||. |    | |  .    . | | . ||..  |||. .|...     | . ||.   . .| .    | ..||||||
....skycnlrv.....tlrktevfad..yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpga...rpwvihcsagv

GRTGTFCTAVIMMKK
||||.|     |...
grtgaflvidamlrq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 117-329 9.5e-36 118.1 In-house 3-199 (239) alignment
Range on Protein: 117-329
Range on HMM: 3-199/239.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG--AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIg
 |. | .||||.||.  .|.|| |.|. .   ||||||.|.      || .|.||| .  .  |||||.|..|  .||||.   |  . || .|||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

geqfSIYGNGNEvfgtySVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnQIIPSSdrnVPIIVHCSAGV
    | | |        ..   ||. |    | |  .    . | | . ||..  |||. .|...     | . ||.   . .| .    | ..||||||
....skycnlrv.....tlrktevfad..yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpga...rpwvihcsagv

GRTGTFCTAVIMMKK
||||.|     |...
grtgaflvidamlrq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 117-322 3.5e-25 83.5 In-house 31-222 (285) alignment
Range on Protein: 117-322
Range on HMM: 31-222/285.0
DKKHNTSKNRYTNILPVNHTRVQLKKiQDKegsDYINANYI--DGAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIG
  . |   |||...  .. ||| ||. .|.   ||| |...   |     .| ||||||.|..|||.|.....   ..||    |    ||  |.||..|
ayeanpdlnryadvrcieetrvvlkn.hdr...dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

gEQFsiygngneVFGTYSVELVEVIQDPEREIITRNIRLTFE----GETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqIIPssdRNVPIIVHC
 |           || | . | |. ..     |  .. ..       |   . . |   |||.  |. ..|. .| . . .    . |   .. || |||
.evv........kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk....vnp...kekpicvhc

SAGVGRTGTFCT
||||||| ||  
sagvgrtatfvg

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-469 3.3e-64 211.6 In-house 25-265 (274) alignment
Range on Protein: 118-469
Range on HMM: 25-265/274.0
KKHNTSKNRYTNILPVNHTRVQL-KKIQDKEGSDYINANYIDGA--YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIG
   ...||||..||| ...|| | .. ...| |.||||||| |     | .. ||||||||.||||||........|||| . .|. . || .|.|....
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

GEQFSIYGNGNevfgtysVELVEVIQDPEREIitRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQiipSSDRNVPIIVHCSAGV
 |    ||. .       .. .....  . ..  |.. |    ..|... | |  ||||. ||..... .|.. . . ...   .. .  |..||||||.
yeiserygdve.......ikvekiverndysv..rklvlkylerersvkhywytdWPdhksPddantlldlvleveesree...enaklapvvvhCsaGi

GRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnnee
|||| | .. | ...|..                                                                                  
GrtGcfiaisiavrqlre..................................................................................

ddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
                    .|  ....|| .|| .| ||||. ||| . .... 
....................eivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 118-331 1.8e-52 173.3 In-house 46-240 (315) alignment
Range on Protein: 118-331
Range on HMM: 46-240/315.0
KKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQigge
| .|  |||| ||.. ...||||  .. ...|||.|||.||| ......|..|||..... ||||.|.|. .  ||||.   |. . |...|||..    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....

qfsiygngNEVFGTYSVELVEviQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIIpssdrnVPIIVHCSAGVGR
        . ..| ..| ...  .. . |.  | .  .|. . |.. |..|  ||| ..| .| |. .|   .   ... .       .|.|||||||||
........kviyGkitvtrks..eevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv......gaivvhcsaGvGr

TGTFCTAVIMMKKLD
||||.|   ......
tGtfitldavldqae

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 119-330 7.7e-31 101.9 In-house 46-246 (305) alignment
Range on Protein: 119-330
Range on HMM: 46-246/305.0
KHNTSKNRYTNILPVNHTRVQLkkiQDKEGSDYINANYID-GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIgGEQ
  .. |||| ..  ... ||.|   .     .|| |||.   . ||.||||| || .| |||| | ....   | ||    |    ||  |.. .  ...
aqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kdv

FSIYGNGNEVFGTYSVEL-VEVIQDPEREIITRNirLTFEG---ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSItnRqnqiiPSsdrNVPIIVHCSAG
...  .|. .   .     ..  .| . ..      |. ||   ..| .|.| .  |||  .|   .   .||.    |     ||     ||.||||||
lefeekgqkisvkfessvtlkfrkdakakvtetv..lviegpgekarkvthyhwidwpdrgvpaadlailelleka..r.....ps...kgpivvhcsag

VGRTGTFCTAVIMMKKL
.||||.      ....|
igrtgsvvmleyildql

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 119-329 7.6e-30 98.9 In-house 41-230 (288) alignment
Range on Protein: 119-329
Range on HMM: 41-230/288.0
KHNTSKNRYTNILPVNHTRVQLKkiqdKEGSDYINANYID-GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgEQ
  |....||.|.   . |||.|.     .   ||.|| .  . |....||.| ||  ||  .|.|. |.  . ||||..  |  . | . |.| ..| |.
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG.ek

FSIYGNgnevfgT------YsvelveviQDPEREIITRNIRLTFEGETRD-ITQYQYEGWPDHNIPDHTQPFRQLLHSItnrqnqiipsSDRNVPIIVHC
  |  .             .        .| .. .    .| . |||..  . .  .  |.|. .|.  ... .||. .           . . ||.||.
arigrl......ctvvkkkr........adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..........kslqkPivvhs

SAGVGRTGTFCTAVIMMKK
|||||||||.   .|... 
saGvGrtgtlililiales

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 119-331 2.4e-23 77.7 In-house 18-219 (290) alignment
Range on Protein: 119-331
Range on HMM: 18-219/290.0
KHNtSKNRYTNILpVNHTRVQLKKIQDKEGSDYINANYIDGAYPKQFICTQGPLPNT-------IADFWRMVWENRCRIIVMLSRESENCRI----KCDR
||.  ..|... | |..||| ||    .  .||| ||..  .   ..| || |. ..       | .|| |. . . . .|||   .|...      | .
khe.mdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPEQIGGEqFsiygngneVFGTYSVELVEVIQDpeREIITRNIRLTFEGET-RDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnqiipssdrNVPI
| ||..|.|           |.  .|.  . ...   ...||.. ..|..|    .| ....|| . |....|. . .|.. . ..          . |.
Yvpesvgee.l........kfkgltvkCkskeke..ddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas..........ktpv

IVHCSAGVGRTGTFCTAVIMMKKLD
||||  |. |  .. .  . . |. 
ivHcvdGiSrsAalaaiilgyQkia

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 119-212 2.8e-10 33.4 In-house 25-87 (169) alignment
Range on Protein: 119-212
Range on HMM: 25-87/169.0
KHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINAnyidgaypkqfictqgplpntiadfwRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
  | .||| .  |  .||||.|... .. |||||||                          ||.||    .||.|    .      . .|||.
tcnetknrpagplapshtrvklqrvmedlgsdyina..........................rmiwetnasvivvlgdtddk.....nnfwpek

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 119-222 7.4e-08 26.1 In-house 49-149 (302) alignment
Range on Protein: 119-222
Range on HMM: 49-149/302.0
KHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGA-YPKQFICTQGPLPNTI---ADFWRMVWENRCRIIVMLSRESENCRiKCDRYWPEQIg
|.|..||. ...  .....|.|.. .|    .|.||  ..     .. | .| |  ..    ..|||||.....  .|.| .| |  .   . ..|..  
kknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks.

gEQFSIYG
 .... ||
.gdykeyg

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 120-329 7.7e-43 141.4 In-house 2-198 (237) alignment
Range on Protein: 120-329
Range on HMM: 2-198/237.0
HNTSKNRYTNILPVNHTRVQLKKIQDKegSDYINANYIDG--AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiggEQ
.|  |||| ||   .|.|| ||    .  ||||||.|..|    ||..|..|||| ..  |||.|||...| .||||.   |. ..|| .|||.    .|
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst...dq

FSIYGNgnevfGTYSVELVEVIQDPEREIITRNIRLTFEgETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRT
 . ||       | |.   | . |     ..   ||| . | | | |||.  |||. .|..|  . .. . | || . .     .  | |.|||||||||
paaygv.....ltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphv....sesgpwiihcsagvgrt

GTFCTAVIMMKK
| |     |...
giflvidamlrq

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 120-211 3.4e-26 86.8 In-house 46-152 (350) alignment
Range on Protein: 120-211
Range on HMM: 46-152/350.0
HNTSKNRYTNILPVNHTRVQLK--------KIQDKEGSDYINANYIDGAY-----PKQ--FICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIK
.  .||||.|||| .|.||.||        |    ...|||||||.  .        .  .| ||.|||.|. ||.... .|  ..|..|. . |. . |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CDRYWPE
|.|||.|
cyrYWqe

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 120-212 3.5e-10 32.9 In-house 25-86 (169) alignment
Range on Protein: 120-212
Range on HMM: 25-86/169.0
HNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINAnyidgaypkqfictqgplpntiadfwRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
 | .||| .  |  .||||.|... .. |||||||                          ||.||    .||.|    .      . .|||.
cnetknrpagplapshtrvklqrvmedlgsdyina..........................rmiwetnasvivvlGdtddk.....nnfwpek

Y_phosphatase Protein-tyrosine phosphatase 121-332 7.1e-66 217.3 Pfam-A 1-199 (235) alignment
Range on Protein: 121-332
Range on HMM: 1-199/235.0
NTSKNRYTNILPVNHTRVQLkkiQDKEG-SDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPeqiggeqf
| .||||..||| ..|||.|   ...|| ||||||||..|   .|.||.|||||..||.|||||||......|||| .. |. | ||..|||        
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

sIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGET---RDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQnqiipsSDRNVPIIVHCSAGVG
    .. . .|...|||.| ... | |...|...|. ..|    | ..|..|..||||..|...... .|.... ...      .... |..||||||||
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvg

RTGTFCTAVIMMKKLDH
|||||... |....|..
Rtgtfvaldilleqlea

Y_phosphatase Protein-tyrosine phosphatase 121-332 7.1e-66 217.3 In-house 1-199 (235) alignment
Range on Protein: 121-332
Range on HMM: 1-199/235.0
NTSKNRYTNILPVNHTRVQLkkiQDKEG-SDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPeqiggeqf
| .||||..||| ..|||.|   ...|| ||||||||..|   .|.||.|||||..||.|||||||......|||| .. |. | ||..|||        
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

sIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGET---RDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQnqiipsSDRNVPIIVHCSAGVG
    .. . .|...|||.| ... | |...|...|. ..|    | ..|..|..||||..|...... .|.... ...      .... |..||||||||
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvg

RTGTFCTAVIMMKKLDH
|||||... |....|..
Rtgtfvaldilleqlea

0041856 (Phosphotyrosine protein) phosphatases II 121-475 2e-50 166.3 In-house 1-174 (182) alignment
Range on Protein: 121-475
Range on HMM: 1-174/182.0
NTSKNRYTNILPVNHTRvqlkkiqdkeGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVMLSresencrikCDRYWPeqiggeqfs
| .||||..|||..|.|          ..||||||...|..|  .||.|||||..|.|||.||..|.....||.|.         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iygngnevfgtysvelveviqdpereiitrnirltfEGETRDITQYQYEGWPDHNIPDhTQPFRQLLHSITNrqnqiipssdRNVPIIVHCSAGVGRTGT
                                    | ..| ..||.| .||||..|| .. . .... . .          .. |..||||||||||||
....................................ellerlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgt

FCTAVIMMKKldhyfkQLDatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneedddda
.. | .|.|.      ...                                                                                 
lvaaylmkkl......gvs.................................................................................

aesdlkyaimdkynsridfnLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
                    |...|  .|..|||||....|| |..  .|......
....................leeavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 121-211 7.2e-19 62.3 In-house 48-155 (349) alignment
Range on Protein: 121-211
Range on HMM: 48-155/349.0
NTSKNRYTNILPVNHTRVQLKKIQD-KE-------------GSDYINANYIDGA---YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRI
  .|||| .||| .|.||.|||     .               |||||||.  .     |..|.|| ||| |. ||....  |. .... |. . |.   
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCDRYWPE
|||.|| |
kcdiywqe

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 121-203 1.1e-06 22.4 In-house 34-116 (332) alignment
Range on Protein: 121-203
Range on HMM: 34-116/332.0
NTSKNRYTNILPVNHTRVQLKKIQDKEgsDYINANYIDGAYPK-QFICTQGPLPN-TIADFWRMVWENRCRIIVMLSRESENCRI
|   ||   .  ..|.||.|   . |.  |. ||...||   |  .| .| |. . |   ||||| | .  .|...    |. . 
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 122-328 4.6e-28 92.8 In-house 51-239 (301) alignment
Range on Protein: 122-328
Range on HMM: 51-239/301.0
TSKNRYTNIlPVNHTrVQLKKIQDKEGsDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsi
  |.|| .. | . .   .. |.| .    | ||.|.    |..||.|||||.||  ||| |.       ||||... |.   ||. | | .|.      
kdkhryptv.PckPs.tavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis......

ygnGNEVFGTYSVELVEVIQDPEREIITRNIRL---TFEGETRDITQYQYEGWPDHNIPD-HTQPFrQLLhsitnrqnQIIPSSDRnvPIIVHCSAGVGR
    .   | .......  .  . .|. |....   | . .|| .| |||. |.|...|  |.. | .|.        ...  |..  ||.||||||.||
...ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelf.dlm........elvkksek..PivvhcsaGiGr

TGTFCTAVIMMK
. .| .. .. .
svafigteylar

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 123-336 4.6e-25 83.0 In-house 45-242 (312) alignment
Range on Protein: 123-336
Range on HMM: 45-242/312.0
SKNRYTNILPVNHTRVQLKKiqDKegSDYINANYID-GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqFsIY
  ||| ||   .  |  |    |.    || ||..   . |..|.|||||| ||.. ||...    .  |..|.   |.   || .|  . .|   | . 
dlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg...f.vd

GNGNEVFGTYSVElVEVIQDPEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqiipssDrNVPIIVHCSAGVGRTGT
 .   |.  |  | .|.       |  | ...     |.   . .||.  |||| .||  .   .|| .. .         | . |.| |||||||||||
ledhrvyteycte.ieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.........d.kkpviahcsagvgrtgt

FCTAVIMMKKLDHYFKQ
..    |.  | |  ||
laliesmiaalrhprkq

0044763 (Phosphotyrosine protein) phosphatases II 132-466 1.8e-37 124.1 In-house 1-165 (178) alignment
Range on Protein: 132-466
Range on HMM: 1-165/178.0
PVNHTRVQLKKIQDKEGSDYINANYIDgayPKQFICTQGPlpntiADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsiygngnevfgty
|. .||| | .... |.||||||..|.   |  ......|     ||......|. .. ||.|. | |. ..|||.||||. |                 
pldrtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

svelveviqdpereiitrnirltfegetrdiTQYQYEGWPDHNIPDHTQPFRQLLHSITNRQnqiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKlD
                                ||.. ..|||. || .. |..... | . .      .... |..|||||||||.||.. | .|.|  .
...............................iqylhipipDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl.g

hyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdk
                                                                                                    
....................................................................................................

ynsridFNLFSIVLKLREQRPgMVQQLEQYLFCYK
      ..|....  .||.|| .|.  .|. ..|.
......lsleeaielvrerRp.ivpnpgqlrqLye

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 138-212 2.2e-07 25.2 In-house 10-72 (130) alignment
Range on Protein: 138-212
Range on HMM: 10-72/130.0
VQlkkiqdkeGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
.|        | .||||...      .... || || .|  |||.|. |    ..|.|    |.     | |||. 
lq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds

0046846 (Phosphotyrosine protein) phosphatases II 143-328 1.2e-37 124.6 In-house 6-134 (176) alignment
Range on Protein: 143-328
Range on HMM: 6-134/176.0
IQDKEGSDYINANYIDGAYpkqFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqigGEQ--Fsiygngnevfgtysvelveviq
. . ...||||||.|.|..   .|.||||||.|.|||..|..|......|.|  | |  |.||..||||    |.  .                      
lgldldldyinanlilgsr...piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi......................

dpereiitrnirltfegetrditQYQYEGWPDHNIPDHtQPFRQLLHSITNRQNQiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMK
                       ||.. .||||..||. . . .||  | .....       . |..||||||.|||||.. | ....
.......................qylhlpwpDhgvpdl.elllellefirealke.......ggpvlVHCsaGigRtgtlvaayllel

0043147 (Phosphotyrosine protein) phosphatases II 147-331 2.5e-37 123.6 In-house 3-128 (172) alignment
Range on Protein: 147-331
Range on HMM: 3-128/172.0
EGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSREsencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpere
||||||||.|.|. |  ..||.|||||.||.||||||..|. ...||.| ..                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

iitrniRLTFEGETRDITQYQYEGWPDHNIPdHTQPFRQLLHSITNRQnqiipSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
       .. |...| . ||.| .||||. | ... ....|. | ...       ... |..||||||||||||.. | .|...|.
......lydpellerlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylmllgls

0051429 (Phosphotyrosine protein) phosphatases II 148-491 3.9e-49 163.0 In-house 3-244 (272) alignment
Range on Protein: 148-491
Range on HMM: 3-244/272.0
GSDYINANYIDGAYP----KQFICTQGPLPNTIADFWRMvWENRCRIIVMLSRESENCRIKCDRYWpEQIGGEQFSIYGNGNEVFGTYSVELVEVIQDPE
 |.||||....| .     . .....||||.|.|||||. .|.... ||.| .|.|  | |||||| ..|   ...|.... .    . . .  .     
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseell

REIITRNIRLT---FEGETRDITQYQYEGWPDHNIPDHTqpFRQLLHSITNrqnqiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKldhyfkqldat
  .| |...||     ||.| .....| .||||..|...  ...||. . .           . |..||||||..||||.. .....             
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvallllllg...........

pidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridFN-
                                                                                                 .. 
.................................................................................................vsl

-------------LFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLNCKLGFSLPHVNNIN
             |. .| .||.||||.||  |||||.|. .|. ..  |...  . | ... |.
etivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid

0036282 (Phosphotyrosine protein) phosphatases II 148-331 3e-39 129.8 In-house 1-132 (174) alignment
Range on Protein: 148-331
Range on HMM: 1-132/174.0
GSDYINANYIDGAYP-KQFICTQGPLPntiadFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqiggeqfsiygngnevfgtysvelveviqdperei
|||||||...|. |  . .|..||||.     ||.|..|......||| .| |. . || .||||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

itrnirlTFEGETRDITQYQYEGWPDHNIPDHTQpFRQLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
       . | ..| . ||.| .||||. || .. .....  . . ...     |.. |..||||||||||||.. | .|.. | 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll

0051082 (Phosphotyrosine protein) phosphatases II 148-331 5.9e-31 102.5 In-house 2-120 (151) alignment
Range on Protein: 148-331
Range on HMM: 2-120/151.0
GSDYINANYIDGAypkqFICTQGPLPntiaDFWRMVWENRCRIIVMLSRESENCriKCDRYWPEQIggeqfsiygngnevfgtysvelveviqdpereii
 |||||..|..|     .....|||.    ||.....|. .. ||.|  | |.   .| .|.||.                                   
lsdyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

trnirltfegetRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
            ..........|||...|.... ....|. . .         ..| |..||||||.|||||.. ...|. ...
............ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllgvs

0049260 (Phosphotyrosine protein) phosphatases II 161-331 1e-34 114.8 In-house 7-117 (152) alignment
Range on Protein: 161-331
Range on HMM: 7-117/152.0
YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr
.|..||.||||.|||.||||||..|. ...|||| ...|. ..||..|.                                                   
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................

ditQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnqiipSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
   ||..  ||||. ||..| ...||. |  .        |.. |..||||||||||||.. | .|.....
...qylhlpwpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylmllgvs

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 163-325 5.9e-19 63.0 In-house 5-157 (199) alignment
Range on Protein: 163-325
Range on HMM: 5-157/199.0
KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRN--IRLTFEGETR
...|.|| || .|.||||.||||     |||.  .  |       |||             |   .|. ||    .   |.  | .       |    ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes.........gtgkygslsvttktittkpdytitaliltnnttappstr

DITQYQYEGWPDHNIPDHTQpFRQLlhSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVI
.|..||.  | ..  |. .  |  .   .. |.       ... |.||||| | | || | .  |
eishyqftswkekttpnval.fvgf..vvasrevskkyeqekdapvivhcsdgqgftgvfvaldi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 163-325 5.9e-19 63.0 In-house 4-156 (198) alignment
Range on Protein: 163-325
Range on HMM: 4-156/198.0
KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRN--IRLTFEGETR
...|.|| || .|.||||.||||     |||.  .  |       |||             |   .|. ||    .   |.  | .       |    ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes.........gtgkygslsvttktittkpdytitaliltnnttappstr

DITQYQYEGWPDHNIPDHTQpFRQLlhSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVI
.|..||.  | ..  |. .  |  .   .. |.       ... |.||||| | | || | .  |
eishyqftswkekttpnval.fvgf..vvasrevskkyeqekdapvivhcsdgqgftgvfvaldi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 164-213 1.9e-07 24.8 In-house 237-283 (440) alignment
Range on Protein: 164-213
Range on HMM: 237-283/440.0
QFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENcriKCDRYWPEQI
 ||.|| ||  |. ||||.| . |   |.|| .  ..    |  ||| . 
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 164-212 8.6e-06 19.5 In-house 138-181 (244) alignment
Range on Protein: 164-212
Range on HMM: 138-181/244.0
QFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
..| || || .|  |||.|. |    ..|.|    |.     | |||. 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 165-332 1.6e-18 61.7 In-house 39-177 (255) alignment
Range on Protein: 165-332
Range on HMM: 39-177/255.0
FictqgplpnTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQfsIYGNGNeVFGTYsvelveVIQDPEreIITRNIRLTFE--GETRDI
.         |.. |....  ..   .|||.   |. . ||..|.| .  . .  .. . | |  |        ..|.   . |..| .|.    .|...
l.........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl..kladvn.vtttk......ssadvv..lrtleitstlgekkkthtv

TQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqiipsSdRnvPIIVHCSAGVGRTGTFCTAVIMMKKLDH
. |.|.||...| |. ..  ...|. ...        | .  ...||||.|.||. .|  | .. .|. .
khysykGWieknaPelareilnilkvvrd........s.k..svvvhCstGiGrsaafvlaelvyqkmir

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 170-321 2.6e-11 37.5 In-house 98-239 (302) alignment
Range on Protein: 170-321
Range on HMM: 98-239/302.0
GPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGE-QFSIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFeGETRDITQYQYE
 |  .|.  .| .. . .  |.| |.   |.   ||  |. ...||| .|  |        |   |. .  .     .  .| . .     . .   .. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafs

GWPDHNIPDHTQPFRQLLHSITnrqnqiipSSDRNVpiIVHCSAGVGRTGTFC
.||||  |.....  ..|.           |  .||  .||||||||||||. 
awpdhGapkeaytaldilkfce........sykknv..lvhcsaGvGrtGtlv

subfamily_hpo-7_pd Subfamily hpo-7 172-330 2e-15 51.4 In-house 43-181 (263) alignment
Range on Protein: 172-330
Range on HMM: 43-181/263.0
LPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQfsIYGNGNeVFGTYSVElveviqdpEREIITRNIRLTFE--GETRDITQYQYEG
| .||. |....  ..   .|||.   |. . ||..|.| .  . |  .. | | |  | ...        .  . |...  |..   .|.....|.| |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq..klanvn.vcttkvqs........dvllktlellstlgeKkkthtvkhysykg

WPDHNIPDHTQPFRQLLHSITNrqnqiipsSdRnvPIIVHCSAGVGRTGTFCTAVIMMKKL
|...| |  ..  ...|.  .|        | .  ...||||.|.||.  |  | .. .|.
Wiekndpelareilnilkvarn........s.k..slvvhcstGiGrsaafsvaElvyqkm

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 235-327 5.8e-11 36.4 In-house 66-151 (440) alignment
Range on Protein: 235-327
Range on HMM: 66-151/440.0
LVEVIQDPEREIITRNirLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssdRNVPIIVHCSAGVGRTGTFCTAVIMM
| ||   |. . |          |.| . ||.|.||||. .|  . |  .... . . |..       | |..||||||.||||   .   ..
leevkgvpdsdyinas..yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.....gngpllvhcsagagrtgviiavdsil

0048179 (Phosphotyrosine protein) phosphatases II 248-328 5.5e-18 60.5 In-house 35-108 (144) alignment
Range on Protein: 248-328
Range on HMM: 35-108/144.0
TRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNqiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMK
. .     | ..| ..||.. .||||..||... ....|. | . ..       .. |..||||||||||||...| .|.|
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmkk

0038934 (Phosphotyrosine protein) phosphatases II 248-328 1.1e-09 33.7 In-house 58-140 (194) alignment
Range on Protein: 248-328
Range on HMM: 58-140/194.0
TRNIRLTFEGETRDITQYQYEGWPDHNIP--D-HTQPFRQLLHSITNRQNQIIPSSDRNvPIIVHCSAGVGRTGTFCTAVIMMK
.  |.|| .. . | . ..  |   ...|  | .| |  ..|... .  ....  .  .  . ||| ||.|||||.. | ....
glvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtlvaaYLiyr

0048076 (Phosphotyrosine protein) phosphatases II 250-328 3.3e-19 64.4 In-house 35-106 (145) alignment
Range on Protein: 250-328
Range on HMM: 35-106/145.0
NIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMK
|.  ..|...| ..||.| .||||..|| .. ....|. | . ...       . |..||||||||||||.. | .|..
nltselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 260-328 4.7e-09 30.0 In-house 218-290 (349) alignment
Range on Protein: 260-328
Range on HMM: 218-290/349.0
RDITQYQYEGWPDHNIPDHTQPFRQLL----HSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMK
  . | |.  |.|  .    . . | |    . | .   .    .|.  ...|||||| ||||...|  ... 
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls

PTPc_DSPc_SM00012 262-339 6e-23 76.4 In-house 2-75 (105) alignment
Range on Protein: 262-339
Range on HMM: 2-75/105.0
ITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIIPssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDA
...|.| |||||..|...... .||... . .|..      . |..|||||||||||||... |....|..  |..| 
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdi

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 262-331 1.5e-11 38.7 In-house 217-290 (350) alignment
Range on Protein: 262-331
Range on HMM: 217-290/350.0
ITQYQYEGWPDHNIPDHTQPFRQLLH----SITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. | |.. |.| ..  . . . | |      | .   .    ..|  ||.||||||||||||..|   ......
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfe

PTPc_motif_SM00404 268-328 2.5e-08 28.9 In-house 45-105 (140) alignment
Range on Protein: 268-328
Range on HMM: 45-105/140.0
EGWPDHNIPDHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMK
.|    .|| . .   .|.. . .  . |  . ...  ..||| ||| |..|...| .|..
sgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmry

subfamily_PTEN_pd Subfamily PTEN 273-330 4e-09 31.7 In-house 85-141 (184) alignment
Range on Protein: 273-330
Range on HMM: 85-141/184.0
HNIPDHTQPFRQLLHSITNRQNQIIPSSDRNVpIIVHCSAGVGRTGTFCTAVIMMKKL
 .. ||. |  .||..| .  .. . ....|| ..||| || ||||.  .| .. ..|
ypfdDhnppplelleeivediekwleedkknv.vvvHCkaGkGRtGvlivayllksll

DSPc Dual specificity phosphatase, catalytic domain 274-329 1.6e-07 26.3 Pfam-A 49-99 (133) alignment
Range on Protein: 274-329
Range on HMM: 49-99/133.0
NipDHTQPFRQLLHSITNRQNQIipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
   .... . . | ....  ...    ...  ..||| ||. |..|...| .|..|
d..etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktk

DSPc Dual specificity phosphatase, catalytic domain 274-329 1.6e-07 26.3 In-house 49-99 (133) alignment
Range on Protein: 274-329
Range on HMM: 49-99/133.0
NipDHTQPFRQLLHSITNRQNQIipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
   .... . . | ....  ...    ...  ..||| ||. |..|...| .|..|
d..etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktk

PTEN_1 275-330 2.2e-08 29.2 In-house 102-157 (196) alignment
Range on Protein: 275-330
Range on HMM: 102-157/196.0
IPDHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
|.||. |  . |. | ..  . . | ...  ..||| ||.||.|| . |  | |. 
ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

subfamily_CG42327_pd Subfamily CG42327 301-338 8.3e-07 23.0 In-house 245-282 (319) alignment
Range on Protein: 301-338
Range on HMM: 245-282/319.0
DRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLD
... |..|||| ||||||.  .. | ...|..  . .|
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvd

0043336 (Phosphotyrosine protein) phosphatases II 426-469 2.8e-08 29.0 In-house 231-274 (278) alignment
Range on Protein: 426-469
Range on HMM: 231-274/278.0
YAIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
| ... ....  ..|...| .|||||||.|| ..|| |.|. .|
yllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0040439 (Phosphotyrosine protein) phosphatases II 426-470 1.3e-07 27.0 In-house 200-244 (249) alignment
Range on Protein: 426-470
Range on HMM: 200-244/249.0
YAIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
| ... .. . ...|...| .||.||||.|| .||| |.|. .|.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

PTPc_DSPc_SM00012 427-469 6.9e-10 34.4 In-house 61-104 (105) alignment
Range on Protein: 427-469
Range on HMM: 61-104/105.0
AIMDKYNSR-IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
 .... ...   ...| || .||.|||||||..|||||.|. .|
illqqleketkevdifqivkelrkqRpgmvqteeqylflyrall

subfamily_PTPRA_pd Subfamily PTPRA 427-477 1.8e-09 32.0 In-house 250-301 (330) alignment
Range on Protein: 427-477
Range on HMM: 250-301/330.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE-IYHRLN
|.... ..    ..| .| .|| ||| ||| .||| |.||..|.  .|   .
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 427-472 3.5e-07 24.8 In-house 246-291 (319) alignment
Range on Protein: 427-472
Range on HMM: 246-291/319.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
...|. .     ... .|  ||.||. .||.| || |.| ..|.| 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 427-471 3.9e-07 24.5 In-house 197-241 (250) alignment
Range on Protein: 427-471
Range on HMM: 197-241/250.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
|.... .     ..| .. .||..||..|. |||| |.|. ||  
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 427-473 4.2e-07 24.8 In-house 210-256 (284) alignment
Range on Protein: 427-473
Range on HMM: 210-256/284.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
...|. .     ... .| .||.||. .||.| || |.| ..|.|  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 427-470 8.6e-07 23.5 In-house 245-288 (298) alignment
Range on Protein: 427-470
Range on HMM: 245-288/298.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
..... .      .| .|  ||..|||.||  ||| |.|. .|.
svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle

Y_phosphatase Protein-tyrosine phosphatase 428-469 3.4e-10 35.1 Pfam-A 193-234 (235) alignment
Range on Protein: 428-469
Range on HMM: 193-234/235.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
.... ... ......|| .||.|||||||.|||| |.||.||
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 428-469 3.4e-10 35.1 In-house 193-234 (235) alignment
Range on Protein: 428-469
Range on HMM: 193-234/235.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
.... ... ......|| .||.|||||||.|||| |.||.||
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_PTPN13_pd Subfamily PTPN13 428-470 3.1e-09 31.5 In-house 225-267 (273) alignment
Range on Protein: 428-470
Range on HMM: 225-267/273.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
...  .   .|..  || |||||| |.||  .||.|.||.||.
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 428-471 1.6e-08 29.0 In-house 239-282 (319) alignment
Range on Protein: 428-471
Range on HMM: 239-282/319.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
.... .     ..||.| .|| ||. |||. ||| |.|...|. 
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 429-472 1.5e-07 25.9 In-house 240-283 (305) alignment
Range on Protein: 429-472
Range on HMM: 240-283/305.0
MDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
... .     ..| .. .||..|..|||.|.|| |..  . ..|
lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_CG7180_pd Subfamily CG7180 429-475 6.3e-07 23.3 In-house 247-293 (296) alignment
Range on Protein: 429-475
Range on HMM: 247-293/296.0
MDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
... .    ...|  | .||..||..|.. |.| ..| ..|. . . 
lelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_PTPN12_pd Subfamily PTPN12 430-477 5.9e-10 33.5 In-house 235-282 (290) alignment
Range on Protein: 430-477
Range on HMM: 235-282/290.0
DKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLN
 . .   ....|..||.||.||. .||  ||| . ||.... . ..|.
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

subfamily_PTPRD_pd Subfamily PTPRD 431-472 1.2e-09 32.4 In-house 240-281 (564) alignment
Range on Protein: 431-472
Range on HMM: 240-281/564.0
KYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
. ..  . .....| .||.||. |||. ||| |....||. .
rikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

subfamily_PTPN9_pd Subfamily PTPN9 431-470 3e-06 21.5 In-house 249-288 (297) alignment
Range on Protein: 431-470
Range on HMM: 249-288/297.0
KYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
. ..    ...  | .||.||  ..|  ||| |||...|.
rleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPRB_pd Subfamily PTPRB 432-473 2.7e-06 21.6 In-house 245-286 (293) alignment
Range on Protein: 432-473
Range on HMM: 245-286/293.0
YNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
 ...   ..|.|| .|||.|  .||  .||.| ....|| . 
ieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 433-473 1.6e-08 29.0 In-house 240-280 (288) alignment
Range on Protein: 433-473
Range on HMM: 240-280/288.0
NSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
..    .....| |||.||. .||.|.|| |.|...|. |.
eeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 433-476 2.4e-06 21.6 In-house 238-281 (315) alignment
Range on Protein: 433-476
Range on HMM: 238-281/315.0
NSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRL
. .   ..| .| .||..|| .||  |.| | | ..|.....| 
krtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 433-471 4.4e-06 21.0 In-house 251-287 (325) alignment
Range on Protein: 433-471
Range on HMM: 251-287/325.0
NSRIDfnLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
.||.|  .|  | |||..|| ||.  .|| ..|... . 
esrvd..ifgfvkklrkdrpsmvetvdqyiliyealvea

subfamily_Ptp69D_pd Subfamily Ptp69D 434-472 1.2e-08 29.4 In-house 248-286 (307) alignment
Range on Protein: 434-472
Range on HMM: 248-286/307.0
SRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
     ..| .| .||.||. .||.|||| |.|. .|| .
aedkvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 436-469 2.1e-07 25.0 In-house 308-341 (350) alignment
Range on Protein: 436-469
Range on HMM: 308-341/350.0
IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
.   .. ||..||.||  |||.|.|..|.|...|
trDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 436-472 1.4e-06 22.5 In-house 223-259 (267) alignment
Range on Protein: 436-472
Range on HMM: 223-259/267.0
IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
   ..|  ..|.|.||.|.|. .|.|....... .  
gvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 436-472 1.8e-06 22.3 In-house 248-284 (297) alignment
Range on Protein: 436-472
Range on HMM: 248-284/297.0
IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
 . ..| .| |||..|| .||  ||| | |...|. .
kevdifglvkklrqerpylvqtkeqykfvyvavleal

0045098 (Phosphotyrosine protein) phosphatases II 437-472 8.7e-07 24.1 In-house 236-272 (278) alignment
Range on Protein: 437-472
Range on HMM: 236-272/278.0
DFNLFSIVLKLREQRPG-MVQQLEQYLFCYKTILDEI
 ..|...| .||.|||| .|| |||| |.|. .|. .
gvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_PTPRG_pd Subfamily PTPRG 437-477 9.1e-06 19.1 In-house 252-292 (563) alignment
Range on Protein: 437-477
Range on HMM: 252-292/563.0
DFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLN
  |.| .. ..| ||. .||. |||.| ....|. |  . .
avnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 439-473 6e-08 27.1 In-house 247-281 (318) alignment
Range on Protein: 439-473
Range on HMM: 247-281/318.0
NLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
..| .| .|||||. |||  .|| |.|...|. . 
Dvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_PTPRK_pd Subfamily PTPRK 439-471 1.3e-06 22.5 In-house 244-276 (314) alignment
Range on Protein: 439-471
Range on HMM: 244-276/314.0
NLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
..| .| .||.... ||.  ||| |.|  ||. 
dvfnavktlrsrkvnmveteeqykfiydvilea

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 439-475 6.1e-06 19.6 In-house 243-279 (515) alignment
Range on Protein: 439-475
Range on HMM: 243-279/515.0
NLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
..| .| ..|..|| .||  ||| | | ..|.... |
dvfnfvtnirqkrpylvqtqeqyafiygavledllwr