Gene ptpA1-1 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily ptpA1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP045_AA protein Get Run
DdisP045_AA_79-473 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 74-476 2.2e-88 291.9 In-house 21-303 (308) alignment 
Range on Protein: 74-476
Range on HMM: 21-303/308.0
LVDEERIKSSIYNLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLkkiqdKEGSDYINANYIDGA---YPKQFICTQG
 ....    .. .| .. .......|||. | .   . |.| . .. | .||||..|||  |.|| |     .||||||||.|.||    .|..||.|||
vsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGeqfsiygnGNEVFGTYSVELVEVIQdpEREIITRNIRLTF--EGETRDITQYQYE
|||||..||||||||...|.|||| .. || |.||..|||. .||        | ...| ..|.|... .  . ....|...||.  .||.| .|...| 
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg........gsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhyt

GWPDHNIPDHTQPFRQLLHSITNRQnqiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglg
.||||..|...... ..|. . ...        .. ||.|||||||||||||... ...  |..                                    
nWpdhgvPpspeilldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqlek....................................

yhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTI
                                                                     ...|..| ||||||||||| .|||||.|...
..................................................................eggvdvfeavkklReqRpgmvqtpeqylflyral

LDEIYHRL
|. .. .|
leylklkl
subfamily_ptpA1_pd Subfamily ptpA1 75-492 4.6e-308 1015.5 In-house 1-418 (418) alignment 
Range on Protein: 75-492
Range on HMM: 1-418/418.0
VDEERIKSSIYNLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPKQFICTQGPLPN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vdeerikssiynlknhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpn

TIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQFSIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhn

IPDHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDATPIDQVVDPFTHLPITEYQSDNLDLKGLGYHFKSS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkss

IYNSNGINNNNNNNLNNNNNINNNSNGSNNTPQTEPNNEEDDDDAAESDLKYAIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYH
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
iynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridfnlfsivlklreqrpgmvqqleqylfcyktildeiyh

RLNCKLGFSLPHVNNINN
||||||||||||||||||
rlncklgfslphvnninn
subfamily_PTPN6_pd Subfamily PTPN6 80-332 5.2e-66 217.7 In-house 9-256 (306) alignment 
Range on Protein: 80-332
Range on HMM: 9-256/306.0
IKSSIYNLKNHIKCIH--KIKEEFRLL--EESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkIQDKEGSDYINANYIDGAYP---KQFICTQGPL
|.. . .|... . ..   ..|||  |  ||.    . .||.|..|..|||| ||||..|||| ||  ..  ||||||||||... .   |..| ||| |
ieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl

PNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygNGNEVFGTYSVELVEViqDPEREIITRNIRL---TFEGETRDITQYQYEG
..|..|||||||.. .|.|||. .| |  . || ||||..          . .| .|..||. |.   .  .. | |....   ....|.|.. ||... 
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPde..........eekeeyGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfks

WPDHNIPDHTQPFRQLLHSITNRQNQIIPSsdRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
||||..| ... . ..|. ....|...  .  .. ||.||||||.||||||    |..|.. .
WPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliek
subfamily_eak_pd Subfamily eak 83-328 4.2e-16 53.2 In-house 20-261 (332) alignment 
Range on Protein: 83-328
Range on HMM: 20-261/332.0
SIYN-LKNHIKCIHKIKEEFRLLEESvgpsetsEGDKKHNTSKNrYTNILPVNHTRVQLKKIQdKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFW
 |.| ....|. .... .  ||| .|       |...  .  .|   .|.| ..  |.|   | ..   ||||  .. .   ...| |  .  . .  ||
hiwnrinqrinivadlddyqrllsis.......etarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafw

RMVWENRCRIIVMLSRESENCRIKCDRYWPEQiGGEQFSiygngnevFGTYSVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQ
.|| |..   ||.|  . |.   | |.|.|.. . |...        || . ||  | ..     . ||.. |.   ||  .  |.. || . ..|   .
qmvleqkspaivqlledvelkleksdkyfpdk.treelk........fGildverkefvkr..niletrllelskGnethrvlhykvfGwtettlpkyed

--PFRQLLHS-----ITNRQNQIIPSSDR--------NVPIIvHCSAGVGRTGTFCTAVIMMK
   .|. .       . . ..... |  .        . |||  .. |  |.|.|    ....
flalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsarGsaraGvfvvidllir
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 84-331 2.4e-69 228.8 In-house 11-241 (318) alignment 
Range on Protein: 84-331
Range on HMM: 11-241/318.0
IYNLKNhiKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRM
. .|..  .   ...||.  |. |   . . .  .. |  ||||.|||. .||||.|......|||||||||||||    |..| .|.|||.|| |||||
vrrlre..sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrm

VWENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTqpf
|||  ...||||..|.|....|..||||..           | . .|.  ||| | ..  .  . . ... | | |.|.. ||.|  |||...|...   
vWeqnsavivmltqeeergkakvhryWPsk...........gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...

RQLLHSItnRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
 .||. .  || . .  .  . ||.|||||||||||.|..  |..... 
aslldlv..rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik
0036941 (Phosphotyrosine protein) phosphatases II 85-478 5.2e-85 280.6 In-house 3-283 (297) alignment 
Range on Protein: 85-478
Range on HMM: 3-283/297.0
YNLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLkkiqDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMV
..|............||. | .   . ..| . .. | .||||..||| .||||.|    |.||||||||.|.|| . ...||.||||||||..||||||
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv

WENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQFSiygngnevfGTYSVELVEVIQDPEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQP
||.....||||... |. |.||..|||. .|...           | ..|.|..| .... ....|....|.  .||.| .|...| |||||..|.....
weqnvtvIvmltelvelgrekcaqywpleegeslty.........gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespas

FRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH--YFKQLDatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsn
. .... . ......     .. |..|||||||||.|||..| .|.  |..  . ...|                                         
lldfielvrkvlkll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd.........................................

ginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridfnLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLNC
                                                            ....|.||||||||.||.||||.|.| ..|. ....|..
............................................................ileavkklReqRpgavqtleqyrflyeallellkkkltk
0039614 (Phosphotyrosine protein) phosphatases II 85-473 4.7e-83 274.4 In-house 22-290 (297) alignment 
Range on Protein: 85-473
Range on HMM: 22-290/297.0
YNLKNHIKCIHKIKEEFRLLEESVGPseTSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDK-EGSDYINANYIDGAY--PKQFICTQGPLPNTIADFWR
..|... ........||  | . . .  .|.. .. | .||||..||| .|.||.|| . .  ..||||||.|.|| .  ...||.||||||.|..||||
llllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MVWENRCRIIVMLSRESENCRiKCDRYWPEQIGgeqfsiygngneVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQP
||||.....|||| .. |. | ||..||||  |            ..|...|.|..|..  .  ...|....| .||.| .|..|| |||||..|.... 
mvweqgvtvivmLtklvelgr.kcaqywpeegg............tygdftvtllkveh..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslel

FRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsngi
. ..|. . .....     ... |..|||||||||||||..| .|.  |.                                                  
lleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqle..................................................

nnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
                                                    .. .......| .|||||||.|| ..|| |.|. .|. . 
....................................................keggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 85-470 1.4e-78 260.1 In-house 17-302 (307) alignment 
Range on Protein: 85-470
Range on HMM: 17-302/307.0
YNLKNHIKCIHKIKEEFRLLEESVG--PSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDK-EGSDYINANYI--------DGA-YPKQFICTQGPL
. |............||. | .     . |.|.. ...| .||||..||| .||||.|. .... |.||||||.|.        ||   ...||.|||||
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

PNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiggEQFSIYGNgnevfgtYSVELVEVIQdpEREIITRNIRLT---FEGETRDITQYQYEG
|.|..|||||.||.....||||... |. |.||..|||.    ...  |||       . |.|... .  . ... |....|   ..||.| .|...| |
petvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygn.......ftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytg

WPDHNIPDHTQPFRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYfkqldatpidqvvdpfthlpiteyqsdnldlkglgy
||||..|...... .... . . ...     ... |..|||||||||||||..| .|.. |..                                     
wpdhgvppsfeelldfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqleke....................................

hfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsrI---DFNLFSIVLKLREQRPGMVQQLEQYLFCYK
                                                                      |..|...| .|||||||.|| .||| |.|.
..................................................................gtlldvdlleavkllreqRpgavqnpeqyrflye

TILD
 .|.
alle
subfamily_PTPRD_pd Subfamily PTPRD 85-332 2.8e-78 259.0 In-house 8-243 (564) alignment 
Range on Protein: 85-332
Range on HMM: 8-243/564.0
YNLKNHIKCIH-----KIKEEFRLLEESvGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIAD
..||.|.. ..     |..||.. .||.   ..... .|..| .|||| ||.. .|.|| |.|.. .||||||||..|||   .|..| |||||..||.|
aelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetied

FWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiGGeqfsiygngnEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDH
|||||||.....||||.. .|. . ||..||||. |           | .| . |.|.|  .  . || | ... . . |.| ..|...  ||||..|..
FWRmvweqnsstiVmltkleEkgkvkchkYWPek.gt..........etygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

TQPFRQLLHSITNRQnQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
.... .|.. ... . .     . . ||.|||||||||||||..  .|.... .
atslLdlirkvraln.e.....pdagPivVhCSaGVGRTGtfividamlerike
0047943 (Phosphotyrosine protein) phosphatases II 86-470 3.7e-83 274.4 In-house 3-270 (273) alignment 
Range on Protein: 86-470
Range on HMM: 3-270/273.0
NLKNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLkkiqDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVW
.| .. .......|||.|| .   . ..| . ...| .||||..|||..|.|| |    . .|||||||.|.||  ....||.||||||||..|||||||
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvw

ENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiyGN-GNEVFGTYSVELVEVIQdpEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQP
|...|.|||| .. |. |.||..|||.          |.   ...| ..|.|... .  .  ...|...||.   ||.| .|...| |||||..|.....
eqnvrviVmLtelvelgrekcaqYwple.........ggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppsles

FRQLLHSITNRQNQIIPSsdrnVPIIVHCSAGVGRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsngi
. .... . . ..... .     |..|||||||||||||... ...  | .                                                 
llefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlek.................................................

nnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
                                                     .  ......| .||.||||||| .|||.|.|...|.
.....................................................eggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPRN_pd Subfamily PTPRN 87-344 9.2e-47 154.2 In-house 21-266 (297) alignment 
Range on Protein: 87-344
Range on HMM: 21-266/297.0
LKNHIKCIHKIKEEFRLLEES-VGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPKQ--FICTQGPLPNTIADFWRMV
|..|.|  .....|.  | .    || .. .....| .|||....|| .|.||.||. ...| ||||||  |    |..  .| |||||..|.||||.||
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmv

WENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVE-VIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPF
||. . .||.|.| .|.   .|.||||..           |.||.. | |.||   |   .  . .  ..     ||| .||. .  ||....|  ....
weqGvvvivnltrleeegvkqckrywpde...........GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksl

RQLlhsiTNRQNQIIPSsdRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDAT-PIDQ
 ..      . |.      |  ||.||||.|.||||...   .....| .  |..| .  .. 
lef....rrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatleh
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 87-169 9.7e-10 32.5 In-house 15-94 (95) alignment 
Range on Protein: 87-169
Range on HMM: 15-94/95.0
LKNHIKCIHKIKEEFRLLEESVGPSETSeGDKKHNTSKNRYTNILPVNHTRVQLKKiqdKEGSDYINANYIDGAYPKQ-FICTQ
|. | .  ... .||. .  . | . |  |  . |  |||. ||.| . ||| |     |  |||||| ..||   |. .|..|
lemhsnsdqefdnefksismtsgapytv.gsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq
0051299 (Phosphotyrosine protein) phosphatases II 88-470 3.4e-86 284.5 In-house 16-284 (288) alignment 
Range on Protein: 88-470
Range on HMM: 16-284/288.0
KNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWEN
| . .......|||. | .   . ..| . ...| .||||..||| .|.||.|. ... ||||||||.||||  ....||.||||||||..||||||||.
kllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweq

RCRIIVMLSRESENCRIKCDRYWPEqiggEQFSIYGNgnevfgtYSVELVEVIQdpEREIITRNIRLT------FEGETRDITQYQYEGWPDHNIPDHTQ
..|.|||| .. |. |.||..|||.    ... .||.       ..|.|... .  . ....|....|      ..||.| .|...| .||||..||...
nvrvIvmltklvelgrekcaqYwpl....ggsltygd.......itvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

PFRQLLHSITNRQNqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsng
.. ..|. . . ..      ... |..|||||||||||||... ...  |.                                                 
llldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqle.................................................

innnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
                                                      .  ......| .|||||||||| .|||.|.|...|.
.....................................................keggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 88-330 2.7e-55 182.7 In-house 15-243 (305) alignment 
Range on Protein: 88-330
Range on HMM: 15-243/305.0
KNHIKCIHKIKEEFRLLEESvgPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWEN
.....  .........| |   .. .  | |..|..|||...| . .. |..|.. .... ||||||.|.||    |..| .||||.||.|||||...| 
earvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrlivee

RCRIIVMLSRESENCRIKCDRYWPEQIGGeqfsiygngNEVFGTYSVELVEVIQDPerEIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFR
. . ||||..  |. . || .||||...          .. || .|||| .  . .  . |.|......   . |.| ..|||   |||| .|. .  . 
kvstivmltklveggkdkCrqYWpeskte.........kkefgefsvelksektas..dyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

QLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
.|.. ....|..     |..||..|||||||||||.|..  |.. .|
slikrvqkdqkk.....dkgvpllVhCsagvgRtGvfiavdialerl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 88-329 1.1e-47 157.3 In-house 13-242 (290) alignment 
Range on Protein: 88-329
Range on HMM: 13-242/290.0
KNHIKCIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEG--SDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVW
..|.|  .. ...|  |. .  . ..  |  . |  .||..||.. .  |. |..|....    .|||| ||.|    ||.| ||||..||..|||...|
nghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

ENRCRIIVMLSRESENCRIKCDRYWPEQigGeqfsiygngNEVFGTYSVELVEVIQDPerEIITRNIRLTFE---GETRDITQYQYEGWPDHNIPDHTQP
.... |||||  . |. . ||  |||..  .         .. .| .|..|..  .    |.|.|..... .   |... .||||   |...    ..| 
qekvtiivmltniieegkvkCqqYWpds..d.........tkaygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

FRQLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
  .... ... | .     . | .|.||||..|||...||.| . ..|
illvieemyktqrk.....rgntsivvHCSdtvgrsavfcaaattink
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 88-329 1.6e-46 153.6 In-house 13-237 (287) alignment 
Range on Protein: 88-329
Range on HMM: 13-237/287.0
KNHIKCIHKIKEEFRLLEE-SVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqdKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWE
|.| |     |. | .||. .  . |   .  ..|  |||.|.||. .  || ||    .|  ||||| .|||    |.|| ...|. ||. .||.....
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWklidd

NRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEviQDPEREIITRNIRLTFEG---ETRDITQYQYEGWPDHN-IPDHTQP
..  .||||..| || . .| .||||.            . |.| |..||..  .. . . | |..... ..   ... ..|||.  |...  ....   
rnvtaivmlcqekendeevcyqyWpee...........ksvvlGeynielln..eevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

FRQLlHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
. .. .     | .       | .|.||||..|||...|| | . ..|
llvi.eemyktqrk.....rgntsivvhCsdtvGrsamfcaaattink
0043336 (Phosphotyrosine protein) phosphatases II 89-333 3.9e-72 238.3 In-house 14-240 (278) alignment 
Range on Protein: 89-333
Range on HMM: 14-240/278.0
NHIKCIHKIKEEFRLLEESVGpSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENR
 . .. .....||  | .     ..| . ...| .||||..||| .|.||.|. ..  ..||||||.|.||   |..||.||||||.|..||||||||..
lllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

CRIIVMLSRESENCRIKCDRYWPeqiggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQL
...|||| .. |. |.||..|||            .| ...|...|.|.....  .  ...|....|   .||.| .|.|.| |||||..|...... ..
vttivmLtelvelgrvkcaqYwp............ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

LHSITNRQNqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
|. . ....      |.| |..|||||||||||||... ...  |...
lkavreale......dsngpvlVHCsaGvgRTGtfialyllleqleke
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 89-330 1.4e-66 219.8 In-house 12-243 (319) alignment 
Range on Protein: 89-330
Range on HMM: 12-243/319.0
NHI-----KCIHKIKEEFRLLEESVGPsETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRM
...     .  .....||.||.|.|   .... .|..| .||||.|||....|||.|......||||||||..|||    ..|| ||.|| ||| |||||
erlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

VWENRCRIIVMLSRESENCRIKCDRYWPEQiggeQFSIYgngnevfGTYSVELVEVIQdpEREIITRNIR---LTFEGETRDITQYQYEGWPDHNIPDHT
|||... |.|||.. .|. ..|. .||||.    .|  |       | . |.| |  .    ..| |..    .. | |||.....||. ||||..|...
vWeeessivvmltklveklkvklkkywpee....nfeey.......Grlivtleeeee..ledyiirklklnkkssevetRevkhfqyteWpdhdvPeka

QPFRQLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
.   .||. | . ...       . ||.|||||||||||||..  .|. ..
tslldllkrirksrek.....tqsgPivvhCsaGvGRtGtfivldamlerv
subfamily_PTPRK_pd Subfamily PTPRK 89-329 2.3e-56 185.9 In-house 11-236 (314) alignment 
Range on Protein: 89-329
Range on HMM: 11-236/314.0
NHIKCIHK-----IKEEFRLLEESvgpseTSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRM
..|.....     .|||.  | |           |..| .|||...||. ...||.|. |..   ||||||..||.   |..|| |||||..|..||||.
qsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

VWENRCRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygngNEVFGTYSVELVEViqDPEREIITRNIRLTF----EGETRDITQYQYEGWPDHNIPDH
|....|  ||||.   |. |.|| .||||.             ||.|   |||||.  ... |...|  |..       |.| . |.|. |||||..| .
vydencasivmltelvevgrvkClkyWPed............tevygdikvelvet..ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs

TQPFRQLLHSITNRQNQiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMKK
 . . .|.. . . |..      .. .|.|||||| ||||||..  |..  
atgllklvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldm
0040438 (Phosphotyrosine protein) phosphatases II 92-486 1e-83 276.6 In-house 15-290 (317) alignment 
Range on Protein: 92-486
Range on HMM: 15-290/317.0
KCIHKIKEEFRLLEESVGPsETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRI
.  ....|||. | .   . ..|.. .. | .||||..|||  |.||.|. ..  ..||||||.|.|| . ...||.||||||||..||||||||.....
sdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLSRESENCRIKCDRYWPEqiggEQFSIYgngnevfGTYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHS
|||| .. |. |.||..|||.    ...  |       |...|.|.....  . .|. |.....   ..|.| .|...| |||||..|...... ..|. 
ivmLteleelgrekcaqYwpl....getlty.......gdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

ITNRQNqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnn
. . ..      |.. |..|||||||||||||..| .|.  |.                                                         
vreale......dpggpvlVHCsaGvgRtGtfiaaylmleqle.........................................................

lnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLNCKLGFSLPH
                                              . .......| .|||||||.|| .||| |.|. .|. ....|...   .|..
.............................................keggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 92-330 1.7e-55 183.3 In-house 24-250 (298) alignment 
Range on Protein: 92-330
Range on HMM: 24-250/298.0
KCIHKIKEEFRLLEESV---GPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENR
| . . ..||. |..        |.. . |..| .||||..|......|| |.|....| |||||| .....   . || ||.||..|..||||||.|. 
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteed

CRIIVMLSRESENCRIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLH
   ||||    |  ..|. .|||..           |.| .|. .|.| .  .  . .. . ..  . | ..| . | ..  |||. .| ...   .||.
igtiVmltnleeldktkyhkywPde...........gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

SITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
 .   |.|       |.|.||.|||||||.|||.    .. ..
kvrasqqq.....agnkpvivqCsaGvgRsGtfiaidsvlerv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 92-330 1e-45 151.1 In-house 13-236 (307) alignment 
Range on Protein: 92-330
Range on HMM: 13-236/307.0
KCIHKIKEEFRLLEESVgPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRI
| ......||| | .   |   .    . || ||||...  ....|. .|   |   |||| |||.  |  ||.|||.|||| ||. .|| |. ...   
kgvqalvdefrvlakkt.pegvtveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMLSRESENCRIKCDRYWPEQIGgeQFSIYGNGNEVFGTYSVELVEVIQDpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIT
..|| .  | ..|||..||| . |  |  ..|. ..      .   ..  | |  |   .... . ...| |...|.| |||. .|.       ||... 
vimlckvielakikceqywpleeg..qklvfgeapntisvanlgakklapd.edlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr

NRQNqiipssdrnvPIIVHCSAGVGRTGTFCTAVIMMKKL
  .|          |..|||||||||.||  .  ... |.
ydtn..........pvvvhcsaGvGrsGtivaislvqdkm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 93-331 3.4e-34 112.9 In-house 22-249 (305) alignment 
Range on Protein: 93-331
Range on HMM: 22-249/305.0
CIHKIKEEFRLLEESVGPSETSE-----GDKKHNTSKNRYTNILPVNHTRVQLKKIQdkeGSDYINANYIDGAY--PKQFICTQGPLPNTIADFWRMVWE
 ..|..|||| |     |  |          . . .||||...   ... |.|.| .    |||| |||.       |.|||.|||| .|| .|| || .
gvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviq

NRCRIIVMLSRESENCRIKCDRYWPEQIGgEQFSIYGN--GNEVFGTYSVElveviQDPEREIITrnIRLTFE-GETRDITQYQYEGWPDHNIPDHTQPF
|.   |||| .  |  ..|| .|||   | |. .. .    ..| |.  .|     .|.| .| .  ..||.  ...  . . |.  |||  .|      
nkveqivmlcktvelgklkcaqywpaaqg.eklelksgivvenvsgskpme.....rdaeiqitl..lnltysgdqkmsvrhlqwtewpdrgvppcklts

RQLLHSITNrqnqiipsSdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
 .|| .|          |  .|||.||||||.|||||  .   ...|. 
lellsairg........s..kvpivvhcsagigrtgtivaieyilekia
subfamily_egg_pd Subfamily egg 93-327 1e-25 85.1 In-house 12-225 (307) alignment 
Range on Protein: 93-327
Range on HMM: 12-225/307.0
CIHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRII
 . ...  . .|||||      .  .. |  | |   .   . .||.|.  . .   |.| ||...|     .||..| || ||  ||||||...... |
ivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLSRESENcrIKCDRYWPEQIGGEQfsiygngNEVFGTYSVELVEVIQDPEREIITRNIRLtfEGETRDITQYQYEGWPDHNIPDHTQPFRQLlHSItn
|||.   |.   .|. |||                | |.. .| ..| . ..      ...|   |  ..    ..  .  .|  |   |.| |   .  
vmltsrkes..erceyywpkaesdsl.......vtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqgdvnnssdvysplrvl.rkl..

RQNqiipssdrNVPIIVHCSAGVGRTGTFCTAVIMM
|.           |..|..  || ...|. .. | .
rnl........skpvvvqdilGvskaatlvaieial
subfamily_PTPRG_pd Subfamily PTPRG 94-332 1.5e-58 193.4 In-house 18-249 (563) alignment 
Range on Protein: 94-332
Range on HMM: 18-249/563.0
IHKIKEEFRLLEESVGPS--ETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGS-DYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCR
 ....|||  |.. . ..  ...  .|..|  ||||.||......||.|... .|... |||||||||| .  |.|| |||||..|. |||||.||..  
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

IIVMLSRESENCRIKCDRYWPE--QIGGEQFSIYGNGNEVFGTYSVElveviqdperEIITRNIRLTFEG---ETRDITQYQYEGWPDHNIPDHTQPfrq
||||..   |. | |||.|||.   .  .....    .||. .|.|.          ... .|..|  .    . . ..||.|  ||||. |.|. |   
iivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr..........tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp...

LLHSITNRqnqIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
 |  .  .        .   ||.||||||||||||..    ..|.. .
vLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq
subfamily_PTPRA_pd Subfamily PTPRA 94-330 4.7e-53 175.2 In-house 31-255 (330) alignment 
Range on Protein: 94-330
Range on HMM: 31-255/330.0
IHKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIV
 ....|||  |  .   .     .|. |  |||. |||| ...|| | ... .| |||||| .|||   | .|| .|||. .|. |||||.|| .   ||
nklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativ

MLSRESENCRIKCDRYWPEQigGeqFSIYGNGnevfgTYSVELVEVIQDP-EREII-TRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIT
||.   |  . || .|||..  |     |||      . .|| ..|..|   |... ..    | | ..| ..|. ...|||  .| ...   .||. . 
mltelkerkeekcaqywPde..G..lvtyGni.....rvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

NRQNQiipssDRNvPIIVHCSAGVGRTGTFCTAVIMMKKL
. ..|       . ||.|||||||||||||..   .....
klnqq.....sag.pivvhcsaGvGrtGtfivldavlerv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 94-325 4.6e-40 132.2 In-house 14-248 (301) alignment 
Range on Protein: 94-325
Range on HMM: 14-248/301.0
IHKIKEEFRLLEESVgPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQ--DKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRI
 .|..|... |.|   . ... | ...|.  ||. || .... |. ||. .  |.   .||||.||||    |.|| .|||. .|..||||..|...   
snkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLSRESENCRIKCDRYWPEQI----GGEQFSIYGNGNEVFGTYSVELVEV-IQDPER-EIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQ
|||.  . |. . || .|||.         .|..  . . |.  . .  . | |||      | |... . . ...|..|.|   ||.. .    .   |
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

LLHSITNRQNQIipssdRNVPIIVHCSAGVGRTGTFCTAVI
 .. .  ||..|        |..||||..|.|.|..|.  |
viddvihrqqki.....gggpvvVHCSdtVsrsGvYcsvsi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 94-333 1.6e-32 107.3 In-house 26-253 (310) alignment 
Range on Protein: 94-333
Range on HMM: 26-253/310.0
IHKIKEEFRLLEESVGPSETSEGDKKhNTSKNRYTNILPVNHTRVQLKkIQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIV
|. .  ..| |.    .| | |  || .  ||||....  . .||.|| |.     ||| |||.   | .  |||.||||  || |||||....|.  |.
ieglvkqyrkldakqdssltyeaykk.ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLSRESENCRIKCDRYWPEQIGGEQFSIYGNGN--EVFGTYSVELVEVIQDPEREIITRNiRLTFegETRDITQYQYEGWPDHNIPDHTqpfrqlLHSIT
.| . .|. | ||  |||     | .      |  |    . .  . |   |.   .  .    .  .   ..  ..  |||  .||         |.. 
llckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeq.panl..kelrvslikwpnwpdrgvpdek......chtvp

NRqnqiIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
.|    . .  |  | .||||||..|... ..  . ..|||. 
qr....llaqvrhgpcvvhcsagkdrlyvvvalklkidkldrg
subfamily_PTPRB_pd Subfamily PTPRB 95-332 7.7e-72 236.8 In-house 25-247 (293) alignment 
Range on Protein: 95-332
Range on HMM: 25-247/293.0
HKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
....||.  |..     ...  ... |..||||||||| .|.||.|....|..||||||||||.|   |..|| ||||||.|. ||||||||....||||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LSRESENCRIKCDRYWPEQiggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQ
| .  |. ..||..|||..          . . ..|  .|.||.  .   .. ..|..... | |.|...||..  ||||..|..|... .... . ...
ltqlvekgkvkCeeYWPad..........eepvlyGdikvtlvaeee..ledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

NQiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
..    . .. ||.||||||||||||| .   .......
ek....taskrPivvhCsaGvGRtGtfialdrllqaiee
subfamily_PTPN9_pd Subfamily PTPN9 95-333 1.1e-61 203.5 In-house 16-253 (297) alignment 
Range on Protein: 95-333
Range on HMM: 16-253/297.0
HKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
. ...|.  . .     .     .. | .|||||..| ...|||.|.|....| |||||||..||   .| || |||||..|. ||||||||.....|||
rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LSRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQ
  |  |. |.|| .|||..          .  . || .||. ||| .  . .. . .|. . ..|.| .| .|. .|||. .|. .. . ..|. . ..|
ttrvvergrlkcgqyWplee.........essaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

NQIIPS-------SDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
 ... .         .. ||.||||||.||||||.|  | ...|.. 
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleev
subfamily_Ptp69D_pd Subfamily Ptp69D 95-331 1.9e-59 196.3 In-house 22-247 (307) alignment 
Range on Protein: 95-331
Range on HMM: 22-247/307.0
HKIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
. ...|.. ||..  . .|. ..|| |. |||| .| . ..|||.||||. || ||||||..| |    |.||. |.|. .|| |||||..|    .|||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LSRESENCRIKCDRYWPEQiggeQFSIYGngnevfgTYSVELVEviQDPEREIITRNIRLTFEG-------ETRDITQYQYEGWPDHNIPDHTQPFRQLL
|| ..|  | ||..|||..    .   ||          |.||.  ..   . | |.. ..  .       ..| ..||.| ||.| ..|....   .|.
lsnlteknrkkcakYWpie....devqyg.......dilvklvs..eekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

HSITNRQNQIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. . . ...       . ||.|||||||||.|.| .  .....| 
eqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlk
DSPc_SM00195 96-472 5.1e-116 382.0 In-house 1-262 (263) alignment 
Range on Protein: 96-472
Range on HMM: 1-262/263.0
KIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
|.||||. ||||  |.||.|..||.|.|||||.||||..||||.|||...||||||||||||.|| ..|..|.||||||.|..||||||||....|||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQDPeREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNR
..|.||...||||||||..         .|.|.||..||.||||.... .|||.|...||.||  |||..|||||..||||..||.|.....||......
teeeengkekcdrywpees.........ggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkks

QNQIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnn
....      ..||.|||||||||||||.|. |...||....|                                                         
ksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk.........................................................

nninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
                                             ...|.|| .||.|||||||.||||||.|..||. |
.............................................vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 96-472 5.1e-116 382.0 In-house 1-262 (263) alignment 
Range on Protein: 96-472
Range on HMM: 1-262/263.0
KIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
|.||||. ||||  |.||.|..||.|.|||||.||||..||||.|||...||||||||||||.|| ..|..|.||||||.|..||||||||....|||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQDPeREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNR
..|.||...||||||||..         .|.|.||..||.||||.... .|||.|...||.||  |||..|||||..||||..||.|.....||......
teeeengkekcdrywpees.........ggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkks

QNQIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnn
....      ..||.|||||||||||||.|. |...||....|                                                         
ksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk.........................................................

nninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
                                             ...|.|| .||.|||||||.||||||.|..||. |
.............................................vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 96-332 1e-63 210.1 In-house 22-241 (288) alignment 
Range on Protein: 96-332
Range on HMM: 22-241/288.0
KIKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVML
 ..||.. | .    .... | . .| .|||| ||||....||.||| ....|.|||||.||||    |..|.|||||..|. |||..|.||.   ||||
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

SRESENCRIKCDRYWPEQiggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
.   |. . ||..|||..          . .. .|   |.|||. .  . ....|.. |  ... ..|||||| .||||..|. ..|. .||. . . ..
telveggktkCeeYWPda..........dkpknyGsvtvtlveske..ledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

QIipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
.         |||||||||||||||| ..  .......
ad......tgpiivhCsaGvGrtgtFialdalidavee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 96-333 3.2e-55 182.7 In-house 35-254 (319) alignment 
Range on Protein: 96-333
Range on HMM: 35-254/319.0
KIKEEFRLL-EESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVM
|.. ||| . . .|  .. .  . ..|  |||..|||. ....|.|.... .|.|||||| ...|   ....| .||||.||.||||||.|| .|  ||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LSresencRIKCDRYWPEQIGGEqfsiYGNGNevfgtYSVELVEVIQDpereIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIt
|.      . || .||| .|  .    .....      .|..||  ..     . |.|.|.    | . |.|||. . ||||.  ||.. .. .|.. . 
lt......kdkcsqywplkivik....eerfk.....vkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv.

nrqNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHY
   . .    . . .|.|||||||||||.. .  ........ 
...rhltskenhranivvhcsaGvGrtGvyivldvlldrmkee
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 96-331 2e-47 156.4 In-house 11-238 (287) alignment 
Range on Protein: 96-331
Range on HMM: 11-238/287.0
KIKEEF-RLLEESVGPSE-TSEGDKKHNTSKNRYTNILPVNHTRVQLKKiQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIV
....|. .| |.| . .    . ..  ...||||...||...||| | . . . |||||||||. .    ..||..|||.. |. ||||.|.|.|   ..
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MLSRESENCRIKCDRYWPEQiggEQFSiygngneVFGTYSVELVE-VIQDPEreIITRNIRLTfEGETRD---ITQYQYEGWPDHNIPDHTQPFRQLLHS
...|| |..| || .||||.   |.           | ||| |..  |..||    .| .||  . |||.   . |...  |||. ..  .  . ..  .
tmtreveearlkcykywPer...evPm.......rvGGysvvlldydikePe..ygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvld

ITNRqNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. ..  ..  ...   |..||...|.||.|.. . ......| 
vkqh.ielardasevGPlvvhddvGiGrsGillatlvlvsrle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 96-330 1.6e-32 107.6 In-house 7-219 (267) alignment 
Range on Protein: 96-330
Range on HMM: 7-219/267.0
KIKEEFRLLEESVGPSET-SEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKegsdYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVM
.|..|| |...    | | |    ..|  .||. . || ..||| |.. ..     |||| |..| . | .|| ||.|| |||.||. .. .... .||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LSRESENcRIKcdRYWPEQIGgeQFSIYgngNEVFGTYSVElvevIQDPEREIITRNIRLTFEGeTRDITQYQYEGWpdhNIPDHTQPFRQLLHSITNRq
| .  ..  |.  ..|| ..|  |   |   ...   .|.|     .. . .||| ....  |  ....| | |. |   ||    .|. . |  |  . 
ltkvftd.nir..lfwPPkmg..qakky...qdltvehsle....keendyqiitlelkfknes.ahnvtlyyykkw...nintnnkpylkplfgilak.

NQIipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
||.    . | |..|.||.||||.||| ..  .....
nql...engnrPlvvacsdGvGrsGtflvidsqlera
0046845 (Phosphotyrosine protein) phosphatases II 97-475 3.5e-83 274.6 In-house 2-277 (284) alignment 
Range on Protein: 97-475
Range on HMM: 2-277/284.0
IKEEFRLLEESVGPS--ETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDK-EGSDYINANYIDG------AYPKQFICTQGPLPNTIADFWRMVWENR
..|||. |   . .   ..| . ...| |||||..||| .|.|| || .... |.||||||.|.||       ..|.||.||||||||..||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CRIIVMLSRESENCRIKCDRYWPEQiGGEQFSiygngnevfGTYSVELVEVIQdpEREIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQ
.|.|||| .. || |.||..|||.  |. .           | ..|.|... .  .  ...|...||.   .||.| .|...| .||||..|...... .
vrvIVmltelvengrekcaqYwple.gevlty.........gdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlle

LLHSITNRQNQiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnn
.|. . . ...    .... ||.|||||||||||||... .... |..                                                    
flrlvrellen....lpgggpivVHCsaGvgRtGtfialdllleqleke...................................................

nnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkyNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
                                                .  . ......| .||||||||||.||||.|.|...|. ....
................................................glllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0045098 (Phosphotyrosine protein) phosphatases II 97-335 3.7e-69 228.5 In-house 9-238 (278) alignment 
Range on Protein: 97-335
Range on HMM: 9-238/278.0
IKEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQlkkiqdkegsDYINANYIDGAyPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSR
.. ||  |     ||| ... .  | .||||..|||..|.||           |||||.||||  ||.||.||||||.|.||||||.||.....|||| .
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmlte

ESENCRIKCDRYWPEqiggEQFSIYgngnevfGTYSVELVEVIQDPEREIITRNIRLT----FEGETRDITQYQYEGWPDHNIPDHT--QPFRQLLHSIT
. |. |.||..||||    ... .|       | ..|.|... . ..  ..| ... .     ..|.| .|...| .||||..|...  ..| .||  | 
lvelgrekcaqywpe....ggslty.......gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

NRQNQIIPS-------SDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFK
........         |.. |..||||||||||||.. | .|.. |.. . 
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd
subfamily_PTPN23_pd Subfamily PTPN23 97-477 4e-58 191.5 In-house 17-285 (288) alignment 
Range on Protein: 97-477
Range on HMM: 17-285/288.0
IKEEFRLLEESVG--PSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGAYPK--QFICTQGPLPNTIADFWRMVWENRCRIIV
....|..||..      ..|    | ...|||...||| .|.||.|.. .|    ||||| .. .  |   .||.||.||..|..|||.||.|.. ..||
ldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

MLSRESENCRIKCDRYWPEQIGGEQfsIYGNgnevfgtYSVELVEVIQDPerEIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSIT
||  ..|  . |.||||||. |  .   .|.       .|| | .| . .  . . |...|....  ......  |.. ||.. .|.  . . |.|. . 
mllskeelgkpkvdrYwPedkgetv..kfgd.......lsvtlksvrete..thvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

NRQNQIIPSSDRnvPIIVHCSAGVGRTGTFCTAVIMMKKLdHYFKQLDatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnln
.  ..    |.   |..|||||||||||.|.  .  ...| .  . |                                                     
sayeavqrkskt..PlvvhCsaGvgRtgvfalvyaavrel.ekgngll....................................................

nnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridfNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLN
                                                ..  .| .|||||  |||. ||. |.|. .| .. . |.
................................................diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 97-329 1.2e-54 180.3 In-house 21-236 (315) alignment 
Range on Protein: 97-329
Range on HMM: 21-236/315.0
IKEEFRLLEESvGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLS
. |||. | .   ....  . .. | .|||| ||||....||.|. |.|.  |||||| || .    | .|..||||. .. ||||||....   |||..
fseefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

RESENCRIKCDRYWPEQIGGeqfSIygngneVFGTYSVELVEViqDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnq
  .|. .||| .|||.. .    |.       ||...|||...  ..  . ..|.. .    |.| .||.|...|||. .. .|  . .|.. .      
kkqegdkikcrqywPdrkad...sv......efGsikvellsl..eadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...

iipSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
      .. ...||||||||||| ....  ....
...ngkkefsllvhcsaGvGrtGvvisidevvaq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 97-324 2.7e-50 166.2 In-house 28-238 (297) alignment 
Range on Protein: 97-324
Range on HMM: 28-238/297.0
IKEEFRLLEESVGPSETsEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPkQFICTQGPLPNTIADFWRMVWENRCRIIVMLSR
 .|||. | |.   ..|   .|| | .|.||.||||..  ||.|. ..|.  |||.|| .. |    ..|.|| | ..|.||||.||....  .||||. 
fseeflclpeaniqpqt.vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnd

ESENCRiKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQpFRQLLHSITNRQN
..|. . || |||...           |   ||. ||.|  | .   .  | |.. .| .    .| . |||.  |||.... . .  ..||. |.. ..
dnerdk.kcaryWsdk...........gvttfGdvsvvllsvse..reGfikrelevtkgkakarrvvkqyqfveWPdkaverkds.assllklisevrk

QIIPSSDRnvPIIVHCSAGVGRTGTFCTAV
.    ..   |..|||.||||||| ..|  
dfsqnaeg..PllvhclaGvGrtgvlltid
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 97-329 2e-46 153.6 In-house 25-247 (325) alignment 
Range on Protein: 97-329
Range on HMM: 25-247/325.0
IKEEFRLLEeSVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVMLS
.  || ||  |...       | .| .|||. |.......|| |.  .|.  ||||||.|.     |  |. .| ||..|| |.||.| . || ..|.| 
fahefgllp.sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvln

rESENCRIKCDRYWPEQIGGeqfsiygngNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQ
 | ..   .|  |||...|             ||.  |.|. . .  .      ... . .|||| . |.|. .|.|   . .   .  .|. . . ...
.eldlgkdrcavywpkemgk.........sktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

IIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
.   .    ||.|||||||||||.| .   ...|
vtantkastpilvhcsaGvGrtGvfislysalak
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 97-346 2.8e-39 129.4 In-house 13-240 (281) alignment 
Range on Protein: 97-346
Range on HMM: 13-240/281.0
IKEEFRLLEESVgPSE-TSEGDKKHNTSKNRYTNILPVNHTRVQLKK-IQDKEGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVM
.|.||  |     ||.  .  ..  |  ||||.||  .. .|||||  . .|. .||| ||||   . |  .| ||||  .| ||||||.|..    |||
fkqefsnlpgdp.psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LSRESENCRIKCDRYWPEQIggeqfsiygNGNEVFGTYSVELVEVIQdpEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRq
| .  |  | ||  |.| .               |  .||.  .     .. ..|  . |..||||| ||.. .. ||| ..|. .. . ..|. |  | 
lcqfletnrekcaeyfprna.........hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.

nqiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDatpIDQVV
           | ..||||||||.||. .  | .. .  .|   |   | |.|
.........stppvihcsagvgrsgtlmaveialqsihshftlpd...ikqiv
subfamily_CG42327_pd Subfamily CG42327 97-291 7.1e-31 102.0 In-house 7-192 (319) alignment 
Range on Protein: 97-291
Range on HMM: 7-192/319.0
IKEEFRLLEESVGPSEtseGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA--YPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
. |||| |   .  ..           |.|. |..|. .||| |..| |.. . |..|.|. |    | ..|..| .| .. .||||.|||.. |.|| |
vaeefrdlPqliarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivql

SRESENCRIKCDRYWPEQIGGEQFSIYGNgnevfgtYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYeGWPDHNIPDHTQPFRQLLHSITN
.  ||.   .| .|.| . .... | ||.       . | | .   . .  | |  ..   . |.|..| | |  |.. ..| . ...  .|  . .
tdlselGikvcaeylPtketldntslyGd.......ilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 98-339 1.4e-61 203.0 In-house 18-244 (281) alignment 
Range on Protein: 98-339
Range on HMM: 18-244/281.0
KEEFRLLEEsVGPSETSEGDK-KHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLS
.||.. |.. .| ..|..  | ..|. ||||.||   ..|||.... .... .||||||...|   .|..| ||||.|.....||.||||.. ..|||. 
ieeyeklaa.igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

RESENCRIKCDRYWPEQIGgeqfsiygngNEVFGTYSVELVEviQDPEREIITRNIRL-TFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
|| |. ..|| ||||..            .  .|.. |. ..  .  ... |.|...| . .||||...| .|  |||| .|. |. . .  . ... ..
reieagklkChrYWPddns..........elkygdvtvksta..eeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklte

qiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDA
     .....|...|||||||||||. .   ..|....  ..|| 
.....kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldv
subfamily_PTPN13_pd Subfamily PTPN13 98-329 4e-53 175.4 In-house 14-228 (273) alignment 
Range on Protein: 98-329
Range on HMM: 14-228/273.0
KEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqdKEGSdYINANYIDG---AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVML
.|||. |.|     ....| ||.|..|||| |.||...|||.|.    .||. ||||..|         ..| .|||||.|..|||.|||| ....|.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

SRESENCRIKCDRYWPEQIGgEQFsiygngnEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
. | |. ..||.|||||. . ..         | . . |||..| .  .  . . ... .  ||.|.... ..  ||||..| ..... |..  . . |.
tlekekgkvkchrywPeskn.kkl.......kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMKK
        . ||.||||||.||.||. |  ...  
.......dagPivvhcsaGiGrsGtlitidvvlgl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 98-160 1.4e-10 35.2 In-house 16-77 (244) alignment 
Range on Protein: 98-160
Range on HMM: 16-77/244.0
KEEFRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKiQDKEGSDYINANYIDGA
||||  | . .     ..     |..|||| ||||...||| |     ||||||||||||.|.
keefvglsdhtreflqtnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 99-320 9.9e-37 121.2 In-house 24-186 (392) alignment 
Range on Protein: 99-320
Range on HMM: 24-186/392.0
EEFRLLEESVGpSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRE
|||. | .    .... . |. |  |||| |||| . .||.|. |.|   |||.|| ||..    | .|..||| . .. ||||||....   |.|... 
eefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl

SENCrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfE-GETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQI
 |                                                           ..| ..|...  |||...| ||  . .... .     | 
kegd......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

ipssdrNVPIIVHCSAGVGRTGTF
        |.|.||||||||||  
......thpliihcsagvgrtgvv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 99-332 2.1e-36 120.3 In-house 24-241 (439) alignment 
Range on Protein: 99-332
Range on HMM: 24-241/439.0
EEFRLLEeSVGPS---ETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVML
|.|  .. |. |    ..|   .... .|||| .. . .|||| |..|     | |||||||.| | .| .| ||||  .|  ||||.|.|...  ||||
eifekin.stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

SRESENCRikcdrYWPEQiggeQFSIYGNGnEVFGTYSVELVEVIQdpeREIITRNIRLTFEGEtRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQN
.   |  .     ||| .    .  .||.   |     .|| . .    | .   | | | | | | . |..|  |||.|.| ..    ..|..|   ..
tnlvesyk.....ywpsd....aevcygdi.avrvdrnielpnyvi...rgfkvfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsand

qiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
     ..   |..||||||||||||  .  | ...|  
.....keeygpvvvhcsagvGrtGtiialdialeqlkl
subfamily_PTPN3_pd Subfamily PTPN3 101-328 6.3e-53 174.5 In-house 21-233 (280) alignment 
Range on Protein: 101-328
Range on HMM: 21-233/280.0
FRLLEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGAYPK-----QFICTQGPLPNTIADFWRMVWENRCRIIVMLS
|  |       ..|.  | .| ||||| .||| ..|||.||. .     |||||||..   |      ..| |||||..| .|||.||||.....|||| 
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

RESENCRIKCDRYWPEQIGGEQfsiygngnevFGTYSVELVEViqDPEREIITRNIRLTFEG--ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQ
   |. |.|| .||||.    .          .|..||.. .   | ......|.. |. .   | | |.| ||  ||||..||... | ...... . .
tlverGrvkChqyWPetedele..........ygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr

nqiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMK
      | .. |..||||||.|||| . .  . . 
......sgkeePvvvhCsaGigrtGvlilletala
subfamily_PTPN14_pd Subfamily PTPN14 104-332 2.5e-51 169.5 In-house 32-258 (300) alignment 
Range on Protein: 104-332
Range on HMM: 32-258/300.0
LEESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKeGSDYINANYID---GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESEN
. .    ...| .  . |..|||. ..|| ...||.|.  ...  ..||||  |    |.  ...| .||||..|. |||.||||.  ..|||| .| |.
ipkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

CRIKCDRYWPEQIGGEQfsiygngNEVFGTYSVElVEVIQDPeREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQPFRQLL---HSITNRQNQ
 . |. .|.|..   ..       .  || . |   .  .|    .||. ..| .   .| |..   ||  ||||..|.  ..| . |   .|. .. |.
gkeksfkyfPkleskkk.......tvefgkfkvt.tkfseds.dsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

IIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDH
 ..| ... |..|||||||||||   .. .... |.|
eveskeskPPvlvhCsaGvGrtGvlilsdlliatleh
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 106-329 6.9e-38 125.1 In-house 18-225 (283) alignment 
Range on Protein: 106-329
Range on HMM: 18-225/283.0
ESVGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYID----GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENC
 || . ..     ..|  |||. .|.|..  ||.||        ||||| .|         |..| .|.|| .|. |||.||....   ||||..  |. 
lsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedl

RIKCDRYWPEQiggeqfsiygnGNEVFGTYSVELVEVIQdpEREIITRNIRLTFE---GETRDITQYQYEGWpdhnipD---HTQPFRQLLhsitnRQNQ
|||| .|||..           | | .| . | | .     ..  | ... |  .    .|  .. ||...|             .   |.     . |.
rikCsqyWPkr...........GsedyGeftvtlrkett..snsfiikelllrvnssakstlllahyqvidW......leygeqaiinslv.....kfnk

IIP--SSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
.|      .. ||.||||.|.|||..|..|.  .|.
vislqteskkgPivvhCstgiGrtavfiaasasvkd
subfamily_CG7180_pd Subfamily CG7180 108-331 1.7e-40 133.5 In-house 29-251 (296) alignment 
Range on Protein: 108-331
Range on HMM: 29-251/296.0
VGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRiKCD
.   .   | .|.|  |||. ...| ...|| |.|.. .| |||||| |.|.   .|..| |..|  .|. .|||.|... .  .|.|... .  . .. 
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

RYWPEQIgGEQFSIYG---NGNEVFGTYSVELVEVIQDperEIITRNIRLTFEGETRDITQYQYEGWPD-HNIPDHTQPFRQLLHSITNRQNQIiPSSDR
 |||..   ||.         .. .       . . .     . . . .   . ||| ....|.  |.  ...|  |. . .|.. .   .... .  . 
sywpnks.keqygeifveiveekqyanlkirtfkltkk...ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpe

NVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. |..|..| |..|.| .... . . ...
egPvvvvssdGasRsGvylaidanlelve
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 108-327 5.8e-36 118.6 In-house 43-240 (290) alignment 
Range on Protein: 108-327
Range on HMM: 43-240/290.0
VGPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqDKEGSDYINANYIDGAYPkQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDR
|.. | .  ||  .  |||| ..   . ||| ||   |    ||. |||..|  .  || |||.| .|. |.|||| ...   ||||    |. . ||..
vqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceq

YWPEQIGgEQFsiygngneVFGTYSVELVeVIQDPEREIITRNI--RLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnqiipssdrNVP
|.||. | | .         || ..|      .|.. .|| . .  |   .|    .  ..   |||. ..  |  . ..|... .           . |
yypekeG.evl........tfGeitvlcs.eeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka..........sGp

IIVHCSAGVGRTGTFCTAVIMM
..||||||.|||||| .  . .
vvvhcsaGiGrtGtfvaievgl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 109-330 1.8e-41 137.0 In-house 21-255 (297) alignment 
Range on Protein: 109-330
Range on HMM: 21-255/297.0
GPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQdkEGSDYINANYI---DGAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKC
 . . |   ..    ||||..|| .. |||.|..     ..|||||.|.   |   . ..|..|||| .|. |||..|.|.  |.|||...  |. | ||
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

DRYWPEQIGGEQFSiygngnevfGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIP---DHTQPFR----------QLLHSITN-
  |||.  .. . .         | . || .    |    .|  ...| .  |.| ..  |. .|||| .|   .  . |.           .. .. . 
apywpsvvqerlka.........gdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvem

-------RQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
       . . .     ||....|||||||||.|    . ....||
ftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilakl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 109-193 2.4e-10 34.5 In-house 25-115 (347) alignment 
Range on Protein: 109-193
Range on HMM: 25-115/347.0
GPSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEG-----SDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVM
 ||. .  . ... ||||  .   .. ||| |   . | .       |||| .|      |..| || |||.|. |||.||   .   .| 
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_PTPN1_pd Subfamily PTPN1 110-333 2.2e-49 162.8 In-house 21-231 (290) alignment 
Range on Protein: 110-333
Range on HMM: 21-231/290.0
PSETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRY
  .|.| ....| ..||| .. | .|.|..|.. .     |||||. ..     ...| ||||||||.. ||.||||.... .||| .  |. .||| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPEQIGgeqfsiygNGNEVFG--TYSVELVEviQDPEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSItnRQNQIIpsSDRNV
||..          . . ..   ...|.|..  .. ... . | ..|.     |||.|... |  |||  .|.  . | ..|. .  |.   .  |.   
wPqgee........ekellledtklkvklis..eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkv..resGsl..ssdvG

PIIVHCSAGVGRTGTFCTAVIMMKKLDHY
| ..|||||.||.|||| .  .. .....
pavihcsaGiGrsGtfclvdtclvliekk
subfamily_PTPN12_pd Subfamily PTPN12 111-331 1.4e-66 219.3 In-house 30-235 (290) alignment 
Range on Protein: 111-331
Range on HMM: 30-235/290.0
SETSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYW
 .|..|.|..|. |||| .||| ...||.|.||...|||||||||.| |.. ....| .|||||.|. |||||.|| . .|.||. || |. ..||.|||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PEQiggeqfsiyGNGNEVFGTYSVELVEViQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNqiipssDRNVPIIVH
||.         |. .  ||...|.| |  .  . ... | .......|.| ..|..|. ||||..|  ...  .|.... ..|.      . ..|..||
pee.........geeelefgefevtleee.kavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe......sedaPlvvh

CSAGVGRTGTFCTAVIMMKKLD
|||||||||| ..  .. . | 
CsaGvGrtGtiiaidyvrellk
0040439 (Phosphotyrosine protein) phosphatases II 113-333 1.2e-68 226.8 In-house 3-209 (249) alignment 
Range on Protein: 113-333
Range on HMM: 3-209/249.0
TSEGDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPE
.|.. .. | .||||..||| .|.||.|. ... ..||||||.|||| | ...||.||||||.|..|||||.||.....||||... |. |.||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

qiggEQFSIYgngnevfGTYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssDRNVPIIVH
    ...  |       |...|.|..|..  . ....|...||   .||.| ....|| .||||..|...... .... . . ....    ... |..||
....ggsley.......gdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVH

CSAGVGRTGTFCTAVIMMKKLDHY
|||||||||||..| .|.  |...
CsaGvgRtGtfiaaylmleqleke
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 113-321 1.1e-18 61.9 In-house 39-229 (303) alignment 
Range on Protein: 113-321
Range on HMM: 39-229/303.0
TSEGDKKHNTSKNRYTNILPVNHTRVQLKkiqDkegSDYINANYIDGAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQ
 |  .  .|  |||..... ..|..|.|    |   | || |.|..    |. | || ||. | ||||.|. |.. . ...|  .||  ..  |  .|..
vsknqfvknmdknrfvdvicldhskvkls...d...ssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

iggEQFSIYGNGNEVFGTYsvELVEVIQDPEREIITrnirLTfEGETR-DITQYQYEGWPDHNIPDHTQPfrQLLHSITNRQNQIIPSSDRNVPIIVhCS
   ..|  . .     | .    ||. .     ...    .. .|. .  .  ..|. ||  .|| .. |  .... | . |  .   || . .. .   
...qdflkfeersirvgef..krvelgdgwvlkvls....vs.ngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysdstptvym.sl

AGVGRTGTFC
.|.||.|||.
sgcgragtfa
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 116-331 8.2e-48 157.8 In-house 4-203 (250) alignment 
Range on Protein: 116-331
Range on HMM: 4-203/250.0
GDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIkCDRYWPEqig
. | .|  ||||..|......|| |.| .  . |||||| ...|    | || |||||..|| ||||||.|.    ||||.  .|. .  . .|||    
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv...

gEQFSIYGNgnevfgtYSVELVEviQDPEREIITRNIRLTFEGETRD--ITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssdRNVPIIVHCSA
 |.  .||.         |.| .  ..   ....|.. |. . .. .  . |...  |||  .|....   .||. .   |.|.      | |.||.|||
.ekaekyGd.......vtvslls..keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.....gnaPvivqCsa

GVGRTGTFCTAVIMMKKLD
||||.|.|..   ....| 
GvgrsGafiaidavlerlk
0049772 (Phosphotyrosine protein) phosphatases II 116-331 6.5e-44 146.3 In-house 41-240 (314) alignment 
Range on Protein: 116-331
Range on HMM: 41-240/314.0
GDKKHNTSKNRYTNILPVNhTRVQLkKIQDKEGSDYINANYIDGAypKQFICTQGPLPNTIADF----------WRMV--WENRCRIIVM----------
.|.  | .||||..|||.. .||.| . .. .|||||||.|.||   ..||.|||||..|. ||          ||||  .....|.|||          
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LSRESENCRIKCDRYWPEQIggeqfsiygngnevfgtysvelvEVIQDPEREiitrnirltfegeTRDITQYQYEGWPDHNIPdHTQPF
           | . ..|  . . .....                         |.. |||.              .| . .| .  .||.. |  .. |
srLdaAlgKtpllildgngneptaadlellk.......................eelydpelf.............erlgikylripvpDgsap.lledf

RQLLHSITNRqnqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
...|. | .         |.. |..|||.||.||||||..| ..||.|.
deflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmkllg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 116-159 6.7e-08 26.3 In-house 42-85 (440) alignment 
Range on Protein: 116-159
Range on HMM: 42-85/440.0
GDKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG
     |  |||| |||  .|.|| |....    |||||| ||.|
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
0042113 (Phosphotyrosine protein) phosphatases II 117-469 6.8e-75 246.9 In-house 5-240 (245) alignment 
Range on Protein: 117-469
Range on HMM: 5-240/245.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqigg
 ...| .||||..||| .||||.|. ..  ..||||||.|.|| . ...||.||||||.|..|||||.||.....||||..| |. |.||..|||.    
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....

EQFSIYGNgnevfgtYSVELVEVIQdpEREIITRNIRLT--FEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQiipssDRNVPIIVHCSAG
...  ||.       ..|.|... .  . ....|....|   ..|.| ...|.| .||||..||... . ..|. . . ...     |.| |..||||||
gesltygd.......ftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaG

VGRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnne
|||||||..| .|.  |..                                                                                 
vgRtGtfiaaylmleqlek.................................................................................

eddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
                     . ...|...| .||.||||.|| ..|| |.|. .|
.....................elgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 117-469 1.7e-68 226.1 In-house 6-239 (243) alignment 
Range on Protein: 117-469
Range on HMM: 6-239/243.0
DKKHNTSKNRYTNILPVNHTRVQLkkiqdkEGSDYINANYIDGAypKQFICTQGPLPNTIAD----FWRMVWENRCRIIVMLSRESENCRIKCDRYWPeq
 .. | |||||..||| .|.|| |      |||||||||.|..   ...|.||||||.|..|    ||||.||.....|||| .. |. |.||..|||  
llpenlsknrysdilpydhsrvkl......egsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

iggeqfsiygnGNEVFGTYSVELVEVIQDPEreIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIIP--SSDRNVPII
           |....|...|.|... . ..  .. |...|.    ...|| ...|.| .||||..||..... ..|. ... ......    |.. |..
...........gevtygdftvtllseehldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSAGVGRTGTFCTAVIMMKKL--Dhyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnnt
||||||||||||...| .|...|  |                                                                          
VHCsaGvgRtGtliaaylmllllgvd..........................................................................

pqtepnneeddddaaesdlkyaimdkynsridfnLFSIVLKLREQRPG-MVQQLEQYLFCYKTIL
                                  |...| .||||||| .|| ..|| |.|. .|
..................................leeavkllreqRpgkavqtpsqyrflyeall
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 117-333 2.1e-55 182.6 In-house 16-227 (270) alignment 
Range on Protein: 117-333
Range on HMM: 16-227/270.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGA--YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqig
.  ...  |||..|||  .|||.|....... . ||||||. |.   .|..|...||||.|. .||||.||.. . |||..   |. | ||.||||.   
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...

geqfsiYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQ---PFRQLLHSITNRQNQIIPSSDRNvPIIVHCS
        . .  . .  .. . . .  |.  |....||. .||.| .. ..|. |||| .| ...     .|||. . . ...    .. . |..||||
......epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcs

AGVGRTGTFCTAVIMMKKLDHY
||||||||. .  |... |.. 
aGvgRtGtlialDiavrlLeet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 117-333 1.9e-54 180.1 In-house 21-218 (284) alignment 
Range on Protein: 117-333
Range on HMM: 21-218/284.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSresencRIKCDRYWPEQIGG
. ..|  |||...||. ....|.|.... .|.|||||| .| |   ....| |||||.||.||||||.|| .|  ||.|.      . || .||| .|  
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

EqfsiYGNGNevfgtYSVELVEVIQDpereIITRNIRLTF---EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSItnrqNQIIPSSDRNVPIIVHCSA
.    .....      .|..||  ..     . |.|.|.    | . |.|.|. . ||||.  ||.. .. .|.. .    . .    . . .|.|||||
k....eerfk.....vkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkv....rhltskenhranivvhcsa

GVGRTGTFCTAVIMMKKLDHY
||||||.. .  ........ 
gvgrtgvyivldvlldrmkee
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 117-325 8.6e-54 177.5 In-house 39-231 (515) alignment 
Range on Protein: 117-325
Range on HMM: 39-231/515.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGG
... | .|||| |||| . .||.|. |.|.  |||.|| || .    | .|..|||.. .. ||||.|....   |.|... .|. .||| .|||.. | 
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

eqfSIygngneVFGTYSVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssdrNVPIIVHCSAGVG
   |.       ||...|||| .  .   . | |..... . ..| .||.....|||. .| ||. . .|.. .   ..|.      . |.|.|||||||
...sv......kfGsikvelvsleac..tggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqy......thpliihcsaGvG

RTGTFCTAVI
||| ....  
rtGvvisids
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 117-329 8.4e-36 118.3 In-house 4-200 (239) alignment 
Range on Protein: 117-329
Range on HMM: 4-200/239.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG--AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIg
 |. | .||||.||.  .|.|| |.|. .   ||||||.|.      || .|.||| .  .  |||||.|..|  .||||.   |  . || .|||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

geqfSIYGNGNEvfgtySVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnQIIPSSdrnVPIIVHCSAGV
    | | |        ..   ||. |    | |  .    . | | . ||..  |||. .|...     | . ||.   . .| .    | ..||||||
....skycnlrv.....tlrktevfad..yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpga...rpwvihcsagv

GRTGTFCTAVIMMKK
||||.|     |...
grtgaflvidamlrq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 117-329 9.5e-36 118.1 In-house 3-199 (239) alignment 
Range on Protein: 117-329
Range on HMM: 3-199/239.0
DKKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG--AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIg
 |. | .||||.||.  .|.|| |.|. .   ||||||.|.      || .|.||| .  .  |||||.|..|  .||||.   |  . || .|||.   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

geqfSIYGNGNEvfgtySVELVEVIQDpeREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnQIIPSSdrnVPIIVHCSAGV
    | | |        ..   ||. |    | |  .    . | | . ||..  |||. .|...     | . ||.   . .| .    | ..||||||
....skycnlrv.....tlrktevfad..yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpga...rpwvihcsagv

GRTGTFCTAVIMMKK
||||.|     |...
grtgaflvidamlrq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 117-322 3.5e-25 83.5 In-house 31-222 (285) alignment 
Range on Protein: 117-322
Range on HMM: 31-222/285.0
DKKHNTSKNRYTNILPVNHTRVQLKKiQDKegsDYINANYI--DGAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIG
  . |   |||...  .. ||| ||. .|.   ||| |...   |     .| ||||||.|..|||.|.....   ..||    |    ||  |.||..|
ayeanpdlnryadvrcieetrvvlkn.hdr...dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

gEQFsiygngneVFGTYSVELVEVIQDPEREIITRNIRLTFE----GETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqIIPssdRNVPIIVHC
 |           || | . | |. ..     |  .. ..       |   . . |   |||.  |. ..|. .| . . .    . |   .. || |||
.evv........kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk....vnp...kekpicvhc

SAGVGRTGTFCT
||||||| ||  
sagvgrtatfvg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-469 3.3e-64 211.6 In-house 25-265 (274) alignment 
Range on Protein: 118-469
Range on HMM: 25-265/274.0
KKHNTSKNRYTNILPVNHTRVQL-KKIQDKEGSDYINANYIDGA--YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIG
   ...||||..||| ...|| | .. ...| |.||||||| |     | .. ||||||||.||||||........|||| . .|. . || .|.|....
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

GEQFSIYGNGNevfgtysVELVEVIQDPEREIitRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQiipSSDRNVPIIVHCSAGV
 |    ||. .       .. .....  . ..  |.. |    ..|... | |  ||||. ||..... .|.. . . ...   .. .  |..||||||.
yeiserygdve.......ikvekiverndysv..rklvlkylerersvkhywytdWPdhksPddantlldlvleveesree...enaklapvvvhCsaGi

GRTGTFCTAVIMMKKLDHyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnnee
|||| | .. | ...|..                                                                                  
GrtGcfiaisiavrqlre..................................................................................

ddddaaesdlkyaimdkynsRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
                    .|  ....|| .|| .| ||||. ||| . .... 
....................eivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 118-331 1.8e-52 173.3 In-house 46-240 (315) alignment 
Range on Protein: 118-331
Range on HMM: 46-240/315.0
KKHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQigge
| .|  |||| ||.. ...||||  .. ...|||.|||.||| ......|..|||..... ||||.|.|. .  ||||.   |. . |...|||..    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....

qfsiygngNEVFGTYSVELVEviQDPEREIITRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIIpssdrnVPIIVHCSAGVGR
        . ..| ..| ...  .. . |.  | .  .|. . |.. |..|  ||| ..| .| |. .|   .   ... .       .|.|||||||||
........kviyGkitvtrks..eevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv......gaivvhcsaGvGr

TGTFCTAVIMMKKLD
||||.|   ......
tGtfitldavldqae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 119-330 7.7e-31 101.9 In-house 46-246 (305) alignment 
Range on Protein: 119-330
Range on HMM: 46-246/305.0
KHNTSKNRYTNILPVNHTRVQLkkiQDKEGSDYINANYID-GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIgGEQ
  .. |||| ..  ... ||.|   .     .|| |||.   . ||.||||| || .| |||| | ....   | ||    |    ||  |.. .  ...
aqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kdv

FSIYGNGNEVFGTYSVEL-VEVIQDPEREIITRNirLTFEG---ETRDITQYQYEGWPDHNIPDHTQPFRQLLHSItnRqnqiiPSsdrNVPIIVHCSAG
...  .|. .   .     ..  .| . ..      |. ||   ..| .|.| .  |||  .|   .   .||.    |     ||     ||.||||||
lefeekgqkisvkfessvtlkfrkdakakvtetv..lviegpgekarkvthyhwidwpdrgvpaadlailelleka..r.....ps...kgpivvhcsag

VGRTGTFCTAVIMMKKL
.||||.      ....|
igrtgsvvmleyildql
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 119-329 7.6e-30 98.9 In-house 41-230 (288) alignment 
Range on Protein: 119-329
Range on HMM: 41-230/288.0
KHNTSKNRYTNILPVNHTRVQLKkiqdKEGSDYINANYID-GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgEQ
  |....||.|.   . |||.|.     .   ||.|| .  . |....||.| ||  ||  .|.|. |.  . ||||..  |  . | . |.| ..| |.
ianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG.ek

FSIYGNgnevfgT------YsvelveviQDPEREIITRNIRLTFEGETRD-ITQYQYEGWPDHNIPDHTQPFRQLLHSItnrqnqiipsSDRNVPIIVHC
  |  .             .        .| .. .    .| . |||..  . .  .  |.|. .|.  ... .||. .           . . ||.||.
arigrl......ctvvkkkr........adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..........kslqkPivvhs

SAGVGRTGTFCTAVIMMKK
|||||||||.   .|... 
saGvGrtgtlililiales
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 119-331 2.4e-23 77.7 In-house 18-219 (290) alignment 
Range on Protein: 119-331
Range on HMM: 18-219/290.0
KHNtSKNRYTNILpVNHTRVQLKKIQDKEGSDYINANYIDGAYPKQFICTQGPLPNT-------IADFWRMVWENRCRIIVMLSRESENCRI----KCDR
||.  ..|... | |..||| ||    .  .||| ||..  .   ..| || |. ..       | .|| |. . . . .|||   .|...      | .
khe.mdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPEQIGGEqFsiygngneVFGTYSVELVEVIQDpeREIITRNIRLTFEGET-RDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnqiipssdrNVPI
| ||..|.|           |.  .|.  . ...   ...||.. ..|..|    .| ....|| . |....|. . .|.. . ..          . |.
Yvpesvgee.l........kfkgltvkCkskeke..ddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas..........ktpv

IVHCSAGVGRTGTFCTAVIMMKKLD
||||  |. |  .. .  . . |. 
ivHcvdGiSrsAalaaiilgyQkia
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 119-212 2.8e-10 33.4 In-house 25-87 (169) alignment 
Range on Protein: 119-212
Range on HMM: 25-87/169.0
KHNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINAnyidgaypkqfictqgplpntiadfwRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
  | .||| .  |  .||||.|... .. |||||||                          ||.||    .||.|    .      . .|||.
tcnetknrpagplapshtrvklqrvmedlgsdyina..........................rmiwetnasvivvlgdtddk.....nnfwpek
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 119-222 7.4e-08 26.1 In-house 49-149 (302) alignment 
Range on Protein: 119-222
Range on HMM: 49-149/302.0
KHNTSKNRYTNILPVNHTRVQLKKIQDkegsDYINANYIDGA-YPKQFICTQGPLPNTI---ADFWRMVWENRCRIIVMLSRESENCRiKCDRYWPEQIg
|.|..||. ...  .....|.|.. .|    .|.||  ..     .. | .| |  ..    ..|||||.....  .|.| .| |  .   . ..|..  
kknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks.

gEQFSIYG
 .... ||
.gdykeyg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 120-329 7.7e-43 141.4 In-house 2-198 (237) alignment 
Range on Protein: 120-329
Range on HMM: 2-198/237.0
HNTSKNRYTNILPVNHTRVQLKKIQDKegSDYINANYIDG--AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQiggEQ
.|  |||| ||   .|.|| ||    .  ||||||.|..|    ||..|..|||| ..  |||.|||...| .||||.   |. ..|| .|||.    .|
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst...dq

FSIYGNgnevfGTYSVELVEVIQDPEREIITRNIRLTFEgETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssDRNVPIIVHCSAGVGRT
 . ||       | |.   | . |     ..   ||| . | | | |||.  |||. .|..|  . .. . | || . .     .  | |.|||||||||
paaygv.....ltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphv....sesgpwiihcsagvgrt

GTFCTAVIMMKK
| |     |...
giflvidamlrq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 120-211 3.4e-26 86.8 In-house 46-152 (350) alignment 
Range on Protein: 120-211
Range on HMM: 46-152/350.0
HNTSKNRYTNILPVNHTRVQLK--------KIQDKEGSDYINANYIDGAY-----PKQ--FICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIK
.  .||||.|||| .|.||.||        |    ...|||||||.  .        .  .| ||.|||.|. ||.... .|  ..|..|. . |. . |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CDRYWPE
|.|||.|
cyrYWqe
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 120-212 3.5e-10 32.9 In-house 25-86 (169) alignment 
Range on Protein: 120-212
Range on HMM: 25-86/169.0
HNTSKNRYTNILPVNHTRVQLKKIQDKEGSDYINAnyidgaypkqfictqgplpntiadfwRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
 | .||| .  |  .||||.|... .. |||||||                          ||.||    .||.|    .      . .|||.
cnetknrpagplapshtrvklqrvmedlgsdyina..........................rmiwetnasvivvlGdtddk.....nnfwpek
Y_phosphatase Protein-tyrosine phosphatase 121-332 7.1e-66 217.3 Pfam-A 1-199 (235) alignment 
Range on Protein: 121-332
Range on HMM: 1-199/235.0
NTSKNRYTNILPVNHTRVQLkkiQDKEG-SDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPeqiggeqf
| .||||..||| ..|||.|   ...|| ||||||||..|   .|.||.|||||..||.|||||||......|||| .. |. | ||..|||        
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

sIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGET---RDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQnqiipsSDRNVPIIVHCSAGVG
    .. . .|...|||.| ... | |...|...|. ..|    | ..|..|..||||..|...... .|.... ...      .... |..||||||||
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvg

RTGTFCTAVIMMKKLDH
|||||... |....|..
Rtgtfvaldilleqlea
Y_phosphatase Protein-tyrosine phosphatase 121-332 7.1e-66 217.3 In-house 1-199 (235) alignment 
Range on Protein: 121-332
Range on HMM: 1-199/235.0
NTSKNRYTNILPVNHTRVQLkkiQDKEG-SDYINANYIDGAY-PKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPeqiggeqf
| .||||..||| ..|||.|   ...|| ||||||||..|   .|.||.|||||..||.|||||||......|||| .. |. | ||..|||        
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp........

sIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFEGET---RDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQnqiipsSDRNVPIIVHCSAGVG
    .. . .|...|||.| ... | |...|...|. ..|    | ..|..|..||||..|...... .|.... ...      .... |..||||||||
.eeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvg

RTGTFCTAVIMMKKLDH
|||||... |....|..
Rtgtfvaldilleqlea
0041856 (Phosphotyrosine protein) phosphatases II 121-475 2e-50 166.3 In-house 1-174 (182) alignment 
Range on Protein: 121-475
Range on HMM: 1-174/182.0
NTSKNRYTNILPVNHTRvqlkkiqdkeGSDYINANYIDGAYPK-QFICTQGPLPNTIADFWRMVWENRCRIIVMLSresencrikCDRYWPeqiggeqfs
| .||||..|||..|.|          ..||||||...|..|  .||.|||||..|.|||.||..|.....||.|.         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iygngnevfgtysvelveviqdpereiitrnirltfEGETRDITQYQYEGWPDHNIPDhTQPFRQLLHSITNrqnqiipssdRNVPIIVHCSAGVGRTGT
                                    | ..| ..||.| .||||..|| .. . .... . .          .. |..||||||||||||
....................................ellerlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgt

FCTAVIMMKKldhyfkQLDatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneedddda
.. | .|.|.      ...                                                                                 
lvaaylmkkl......gvs.................................................................................

aesdlkyaimdkynsridfnLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
                    |...|  .|..|||||....|| |..  .|......
....................leeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 121-211 7.2e-19 62.3 In-house 48-155 (349) alignment 
Range on Protein: 121-211
Range on HMM: 48-155/349.0
NTSKNRYTNILPVNHTRVQLKKIQD-KE-------------GSDYINANYIDGA---YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRI
  .|||| .||| .|.||.|||     .               |||||||.  .     |..|.|| ||| |. ||....  |. .... |. . |.   
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCDRYWPE
|||.|| |
kcdiywqe
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 121-203 1.1e-06 22.4 In-house 34-116 (332) alignment 
Range on Protein: 121-203
Range on HMM: 34-116/332.0
NTSKNRYTNILPVNHTRVQLKKIQDKEgsDYINANYIDGAYPK-QFICTQGPLPN-TIADFWRMVWENRCRIIVMLSRESENCRI
|   ||   .  ..|.||.|   . |.  |. ||...||   |  .| .| |. . |   ||||| | .  .|...    |. . 
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 122-328 4.6e-28 92.8 In-house 51-239 (301) alignment 
Range on Protein: 122-328
Range on HMM: 51-239/301.0
TSKNRYTNIlPVNHTrVQLKKIQDKEGsDYINANYIDG-AYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsi
  |.|| .. | . .   .. |.| .    | ||.|.    |..||.|||||.||  ||| |.       ||||... |.   ||. | | .|.      
kdkhryptv.PckPs.tavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis......

ygnGNEVFGTYSVELVEVIQDPEREIITRNIRL---TFEGETRDITQYQYEGWPDHNIPD-HTQPFrQLLhsitnrqnQIIPSSDRnvPIIVHCSAGVGR
    .   | .......  .  . .|. |....   | . .|| .| |||. |.|...|  |.. | .|.        ...  |..  ||.||||||.||
...ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelf.dlm........elvkksek..PivvhcsaGiGr

TGTFCTAVIMMK
. .| .. .. .
svafigteylar
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 123-336 4.6e-25 83.0 In-house 45-242 (312) alignment 
Range on Protein: 123-336
Range on HMM: 45-242/312.0
SKNRYTNILPVNHTRVQLKKiqDKegSDYINANYID-GAYPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqFsIY
  ||| ||   .  |  |    |.    || ||..   . |..|.|||||| ||.. ||...    .  |..|.   |.   || .|  . .|   | . 
dlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg...f.vd

GNGNEVFGTYSVElVEVIQDPEREIITRNIRLTF--EGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqiipssDrNVPIIVHCSAGVGRTGT
 .   |.  |  | .|.       |  | ...     |.   . .||.  |||| .||  .   .|| .. .         | . |.| |||||||||||
ledhrvyteycte.ieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.........d.kkpviahcsagvgrtgt

FCTAVIMMKKLDHYFKQ
..    |.  | |  ||
laliesmiaalrhprkq
0044763 (Phosphotyrosine protein) phosphatases II 132-466 1.8e-37 124.1 In-house 1-165 (178) alignment 
Range on Protein: 132-466
Range on HMM: 1-165/178.0
PVNHTRVQLKKIQDKEGSDYINANYIDgayPKQFICTQGPlpntiADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsiygngnevfgty
|. .||| | .... |.||||||..|.   |  ......|     ||......|. .. ||.|. | |. ..|||.||||. |                 
pldrtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

svelveviqdpereiitrnirltfegetrdiTQYQYEGWPDHNIPDHTQPFRQLLHSITNRQnqiipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKlD
                                ||.. ..|||. || .. |..... | . .      .... |..|||||||||.||.. | .|.|  .
...............................iqylhipipDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl.g

hyfkqldatpidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdk
                                                                                                    
....................................................................................................

ynsridFNLFSIVLKLREQRPgMVQQLEQYLFCYK
      ..|....  .||.|| .|.  .|. ..|.
......lsleeaielvrerRp.ivpnpgqlrqLye
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 138-212 2.2e-07 25.2 In-house 10-72 (130) alignment 
Range on Protein: 138-212
Range on HMM: 10-72/130.0
VQlkkiqdkeGSDYINANYIDGA-YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
.|        | .||||...      .... || || .|  |||.|. |    ..|.|    |.     | |||. 
lq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds
0046846 (Phosphotyrosine protein) phosphatases II 143-328 1.2e-37 124.6 In-house 6-134 (176) alignment 
Range on Protein: 143-328
Range on HMM: 6-134/176.0
IQDKEGSDYINANYIDGAYpkqFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqigGEQ--Fsiygngnevfgtysvelveviq
. . ...||||||.|.|..   .|.||||||.|.|||..|..|......|.|  | |  |.||..||||    |.  .                      
lgldldldyinanlilgsr...piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi......................

dpereiitrnirltfegetrditQYQYEGWPDHNIPDHtQPFRQLLHSITNRQNQiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMK
                       ||.. .||||..||. . . .||  | .....       . |..||||||.|||||.. | ....
.......................qylhlpwpDhgvpdl.elllellefirealke.......ggpvlVHCsaGigRtgtlvaayllel
0043147 (Phosphotyrosine protein) phosphatases II 147-331 2.5e-37 123.6 In-house 3-128 (172) alignment 
Range on Protein: 147-331
Range on HMM: 3-128/172.0
EGSDYINANYIDGAYP-KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSREsencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpere
||||||||.|.|. |  ..||.|||||.||.||||||..|. ...||.| ..                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

iitrniRLTFEGETRDITQYQYEGWPDHNIPdHTQPFRQLLHSITNRQnqiipSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
       .. |...| . ||.| .||||. | ... ....|. | ...       ... |..||||||||||||.. | .|...|.
......lydpellerlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylmllgls
0051429 (Phosphotyrosine protein) phosphatases II 148-491 3.9e-49 163.0 In-house 3-244 (272) alignment 
Range on Protein: 148-491
Range on HMM: 3-244/272.0
GSDYINANYIDGAYP----KQFICTQGPLPNTIADFWRMvWENRCRIIVMLSRESENCRIKCDRYWpEQIGGEQFSIYGNGNEVFGTYSVELVEVIQDPE
 |.||||....| .     . .....||||.|.|||||. .|.... ||.| .|.|  | |||||| ..|   ...|.... .    . . .  .     
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseell

REIITRNIRLT---FEGETRDITQYQYEGWPDHNIPDHTqpFRQLLHSITNrqnqiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKldhyfkqldat
  .| |...||     ||.| .....| .||||..|...  ...||. . .           . |..||||||..||||.. .....             
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvallllllg...........

pidqvvdpfthlpiteyqsdnldlkglgyhfkssiynsnginnnnnnnlnnnnninnnsngsnntpqtepnneeddddaaesdlkyaimdkynsridFN-
                                                                                                 .. 
.................................................................................................vsl

-------------LFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLNCKLGFSLPHVNNIN
             |. .| .||.||||.||  |||||.|. .|. ..  |...  . | ... |.
etivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid
0036282 (Phosphotyrosine protein) phosphatases II 148-331 3e-39 129.8 In-house 1-132 (174) alignment 
Range on Protein: 148-331
Range on HMM: 1-132/174.0
GSDYINANYIDGAYP-KQFICTQGPLPntiadFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEqiggeqfsiygngnevfgtysvelveviqdperei
|||||||...|. |  . .|..||||.     ||.|..|......||| .| |. . || .||||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

itrnirlTFEGETRDITQYQYEGWPDHNIPDHTQpFRQLLHSITNRQNQiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
       . | ..| . ||.| .||||. || .. .....  . . ...     |.. |..||||||||||||.. | .|.. | 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll
0051082 (Phosphotyrosine protein) phosphatases II 148-331 5.9e-31 102.5 In-house 2-120 (151) alignment 
Range on Protein: 148-331
Range on HMM: 2-120/151.0
GSDYINANYIDGAypkqFICTQGPLPntiaDFWRMVWENRCRIIVMLSRESENCriKCDRYWPEQIggeqfsiygngnevfgtysvelveviqdpereii
 |||||..|..|     .....|||.    ||.....|. .. ||.|  | |.   .| .|.||.                                   
lsdyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

trnirltfegetRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqiipssDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
            ..........|||...|.... ....|. . .         ..| |..||||||.|||||.. ...|. ...
............ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllgvs
0049260 (Phosphotyrosine protein) phosphatases II 161-331 1e-34 114.8 In-house 7-117 (152) alignment 
Range on Protein: 161-331
Range on HMM: 7-117/152.0
YPKQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr
.|..||.||||.|||.||||||..|. ...|||| ...|. ..||..|.                                                   
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................

ditQYQYEGWPDHNIPDHTQPFRQLLHSITNRqnqiipSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
   ||..  ||||. ||..| ...||. |  .        |.. |..||||||||||||.. | .|.....
...qylhlpwpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylmllgvs
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 163-325 5.9e-19 63.0 In-house 5-157 (199) alignment 
Range on Protein: 163-325
Range on HMM: 5-157/199.0
KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRN--IRLTFEGETR
...|.|| || .|.||||.||||     |||.  .  |       |||             |   .|. ||    .   |.  | .       |    ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes.........gtgkygslsvttktittkpdytitaliltnnttappstr

DITQYQYEGWPDHNIPDHTQpFRQLlhSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVI
.|..||.  | ..  |. .  |  .   .. |.       ... |.||||| | | || | .  |
eishyqftswkekttpnval.fvgf..vvasrevskkyeqekdapvivhcsdgqgftgvfvaldi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 163-325 5.9e-19 63.0 In-house 4-156 (198) alignment 
Range on Protein: 163-325
Range on HMM: 4-156/198.0
KQFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGgeqfsiygnGNEVFGTYSVELVEVIQDPEREIITRN--IRLTFEGETR
...|.|| || .|.||||.||||     |||.  .  |       |||             |   .|. ||    .   |.  | .       |    ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes.........gtgkygslsvttktittkpdytitaliltnnttappstr

DITQYQYEGWPDHNIPDHTQpFRQLlhSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVI
.|..||.  | ..  |. .  |  .   .. |.       ... |.||||| | | || | .  |
eishyqftswkekttpnval.fvgf..vvasrevskkyeqekdapvivhcsdgqgftgvfvaldi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 164-213 1.9e-07 24.8 In-house 237-283 (440) alignment 
Range on Protein: 164-213
Range on HMM: 237-283/440.0
QFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENcriKCDRYWPEQI
 ||.|| ||  |. ||||.| . |   |.|| .  ..    |  ||| . 
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 164-212 8.6e-06 19.5 In-house 138-181 (244) alignment 
Range on Protein: 164-212
Range on HMM: 138-181/244.0
QFICTQGPLPNTIADFWRMVWENRCRIIVMLSRESENcrikcDRYWPEQ
..| || || .|  |||.|. |    ..|.|    |.     | |||. 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 165-332 1.6e-18 61.7 In-house 39-177 (255) alignment 
Range on Protein: 165-332
Range on HMM: 39-177/255.0
FictqgplpnTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQfsIYGNGNeVFGTYsvelveVIQDPEreIITRNIRLTFE--GETRDI
.         |.. |....  ..   .|||.   |. . ||..|.| .  . .  .. . | |  |        ..|.   . |..| .|.    .|...
l.........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl..kladvn.vtttk......ssadvv..lrtleitstlgekkkthtv

TQYQYEGWPDHNIPDHTQPFRQLLHSITNrqnqiipsSdRnvPIIVHCSAGVGRTGTFCTAVIMMKKLDH
. |.|.||...| |. ..  ...|. ...        | .  ...||||.|.||. .|  | .. .|. .
khysykGWieknaPelareilnilkvvrd........s.k..svvvhCstGiGrsaafvlaelvyqkmir
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 170-321 2.6e-11 37.5 In-house 98-239 (302) alignment 
Range on Protein: 170-321
Range on HMM: 98-239/302.0
GPLPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGE-QFSIYGNGNEVFGTYSVELVEVIQDPEREIITRNIRLTFeGETRDITQYQYE
 |  .|.  .| .. . .  |.| |.   |.   ||  |. ...||| .|  |        |   |. .  .     .  .| . .     . .   .. 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafs

GWPDHNIPDHTQPFRQLLHSITnrqnqiipSSDRNVpiIVHCSAGVGRTGTFC
.||||  |.....  ..|.           |  .||  .||||||||||||. 
awpdhGapkeaytaldilkfce........sykknv..lvhcsaGvGrtGtlv
subfamily_hpo-7_pd Subfamily hpo-7 172-330 2e-15 51.4 In-house 43-181 (263) alignment 
Range on Protein: 172-330
Range on HMM: 43-181/263.0
LPNTIADFWRMVWENRCRIIVMLSRESENCRIKCDRYWPEQIGGEQfsIYGNGNeVFGTYSVElveviqdpEREIITRNIRLTFE--GETRDITQYQYEG
| .||. |....  ..   .|||.   |. . ||..|.| .  . |  .. | | |  | ...        .  . |...  |..   .|.....|.| |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq..klanvn.vcttkvqs........dvllktlellstlgeKkkthtvkhysykg

WPDHNIPDHTQPFRQLLHSITNrqnqiipsSdRnvPIIVHCSAGVGRTGTFCTAVIMMKKL
|...| |  ..  ...|.  .|        | .  ...||||.|.||.  |  | .. .|.
Wiekndpelareilnilkvarn........s.k..slvvhcstGiGrsaafsvaElvyqkm
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 235-327 5.8e-11 36.4 In-house 66-151 (440) alignment 
Range on Protein: 235-327
Range on HMM: 66-151/440.0
LVEVIQDPEREIITRNirLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIipssdRNVPIIVHCSAGVGRTGTFCTAVIMM
| ||   |. . |          |.| . ||.|.||||. .|  . |  .... . . |..       | |..||||||.||||   .   ..
leevkgvpdsdyinas..yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.....gngpllvhcsagagrtgviiavdsil
0048179 (Phosphotyrosine protein) phosphatases II 248-328 5.5e-18 60.5 In-house 35-108 (144) alignment 
Range on Protein: 248-328
Range on HMM: 35-108/144.0
TRNIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNqiipssdRNVPIIVHCSAGVGRTGTFCTAVIMMK
. .     | ..| ..||.. .||||..||... ....|. | . ..       .. |..||||||||||||...| .|.|
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmkk
0038934 (Phosphotyrosine protein) phosphatases II 248-328 1.1e-09 33.7 In-house 58-140 (194) alignment 
Range on Protein: 248-328
Range on HMM: 58-140/194.0
TRNIRLTFEGETRDITQYQYEGWPDHNIP--D-HTQPFRQLLHSITNRQNQIIPSSDRNvPIIVHCSAGVGRTGTFCTAVIMMK
.  |.|| .. . | . ..  |   ...|  | .| |  ..|... .  ....  .  .  . ||| ||.|||||.. | ....
glvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtlvaaYLiyr
0048076 (Phosphotyrosine protein) phosphatases II 250-328 3.3e-19 64.4 In-house 35-106 (145) alignment 
Range on Protein: 250-328
Range on HMM: 35-106/145.0
NIRLTFEGETRDITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQiipssdrNVPIIVHCSAGVGRTGTFCTAVIMMK
|.  ..|...| ..||.| .||||..|| .. ....|. | . ...       . |..||||||||||||.. | .|..
nltselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 260-328 4.7e-09 30.0 In-house 218-290 (349) alignment 
Range on Protein: 260-328
Range on HMM: 218-290/349.0
RDITQYQYEGWPDHNIPDHTQPFRQLL----HSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMK
  . | |.  |.|  .    . . | |    . | .   .    .|.  ...|||||| ||||...|  ... 
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
PTPc_DSPc_SM00012 262-339 6e-23 76.4 In-house 2-75 (105) alignment 
Range on Protein: 262-339
Range on HMM: 2-75/105.0
ITQYQYEGWPDHNIPDHTQPFRQLLHSITNRQNQIIPssdrNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLDA
...|.| |||||..|...... .||... . .|..      . |..|||||||||||||... |....|..  |..| 
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 262-331 1.5e-11 38.7 In-house 217-290 (350) alignment 
Range on Protein: 262-331
Range on HMM: 217-290/350.0
ITQYQYEGWPDHNIPDHTQPFRQLLH----SITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKLD
. | |.. |.| ..  . . . | |      | .   .    ..|  ||.||||||||||||..|   ......
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfe
PTPc_motif_SM00404 268-328 2.5e-08 28.9 In-house 45-105 (140) alignment 
Range on Protein: 268-328
Range on HMM: 45-105/140.0
EGWPDHNIPDHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMK
.|    .|| . .   .|.. . .  . |  . ...  ..||| ||| |..|...| .|..
sgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmry
subfamily_PTEN_pd Subfamily PTEN 273-330 4e-09 31.7 In-house 85-141 (184) alignment 
Range on Protein: 273-330
Range on HMM: 85-141/184.0
HNIPDHTQPFRQLLHSITNRQNQIIPSSDRNVpIIVHCSAGVGRTGTFCTAVIMMKKL
 .. ||. |  .||..| .  .. . ....|| ..||| || ||||.  .| .. ..|
ypfdDhnppplelleeivediekwleedkknv.vvvHCkaGkGRtGvlivayllksll
DSPc Dual specificity phosphatase, catalytic domain 274-329 1.6e-07 26.3 Pfam-A 49-99 (133) alignment 
Range on Protein: 274-329
Range on HMM: 49-99/133.0
NipDHTQPFRQLLHSITNRQNQIipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
   .... . . | ....  ...    ...  ..||| ||. |..|...| .|..|
d..etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktk
DSPc Dual specificity phosphatase, catalytic domain 274-329 1.6e-07 26.3 In-house 49-99 (133) alignment 
Range on Protein: 274-329
Range on HMM: 49-99/133.0
NipDHTQPFRQLLHSITNRQNQIipsSDRNVPIIVHCSAGVGRTGTFCTAVIMMKK
   .... . . | ....  ...    ...  ..||| ||. |..|...| .|..|
d..etetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktk
PTEN_1 275-330 2.2e-08 29.2 In-house 102-157 (196) alignment 
Range on Protein: 275-330
Range on HMM: 102-157/196.0
IPDHTQPFRQLLHSITNRQNQIIPSSDRNVPIIVHCSAGVGRTGTFCTAVIMMKKL
|.||. |  . |. | ..  . . | ...  ..||| ||.||.|| . |  | |. 
ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk
subfamily_CG42327_pd Subfamily CG42327 301-338 8.3e-07 23.0 In-house 245-282 (319) alignment 
Range on Protein: 301-338
Range on HMM: 245-282/319.0
DRNVPIIVHCSAGVGRTGTFCTAVIMMKKLDHYFKQLD
... |..|||| ||||||.  .. | ...|..  . .|
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvd
0043336 (Phosphotyrosine protein) phosphatases II 426-469 2.8e-08 29.0 In-house 231-274 (278) alignment 
Range on Protein: 426-469
Range on HMM: 231-274/278.0
YAIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
| ... ....  ..|...| .|||||||.|| ..|| |.|. .|
yllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 426-470 1.3e-07 27.0 In-house 200-244 (249) alignment 
Range on Protein: 426-470
Range on HMM: 200-244/249.0
YAIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
| ... .. . ...|...| .||.||||.|| .||| |.|. .|.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
PTPc_DSPc_SM00012 427-469 6.9e-10 34.4 In-house 61-104 (105) alignment 
Range on Protein: 427-469
Range on HMM: 61-104/105.0
AIMDKYNSR-IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
 .... ...   ...| || .||.|||||||..|||||.|. .|
illqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_PTPRA_pd Subfamily PTPRA 427-477 1.8e-09 32.0 In-house 250-301 (330) alignment 
Range on Protein: 427-477
Range on HMM: 250-301/330.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE-IYHRLN
|.... ..    ..| .| .|| ||| ||| .||| |.||..|.  .|   .
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 427-472 3.5e-07 24.8 In-house 246-291 (319) alignment 
Range on Protein: 427-472
Range on HMM: 246-291/319.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
...|. .     ... .|  ||.||. .||.| || |.| ..|.| 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 427-471 3.9e-07 24.5 In-house 197-241 (250) alignment 
Range on Protein: 427-471
Range on HMM: 197-241/250.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
|.... .     ..| .. .||..||..|. |||| |.|. ||  
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 427-473 4.2e-07 24.8 In-house 210-256 (284) alignment 
Range on Protein: 427-473
Range on HMM: 210-256/284.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
...|. .     ... .| .||.||. .||.| || |.| ..|.|  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 427-470 8.6e-07 23.5 In-house 245-288 (298) alignment 
Range on Protein: 427-470
Range on HMM: 245-288/298.0
AIMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
..... .      .| .|  ||..|||.||  ||| |.|. .|.
svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
Y_phosphatase Protein-tyrosine phosphatase 428-469 3.4e-10 35.1 Pfam-A 193-234 (235) alignment 
Range on Protein: 428-469
Range on HMM: 193-234/235.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
.... ... ......|| .||.|||||||.|||| |.||.||
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 428-469 3.4e-10 35.1 In-house 193-234 (235) alignment 
Range on Protein: 428-469
Range on HMM: 193-234/235.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
.... ... ......|| .||.|||||||.|||| |.||.||
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN13_pd Subfamily PTPN13 428-470 3.1e-09 31.5 In-house 225-267 (273) alignment 
Range on Protein: 428-470
Range on HMM: 225-267/273.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
...  .   .|..  || |||||| |.||  .||.|.||.||.
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 428-471 1.6e-08 29.0 In-house 239-282 (319) alignment 
Range on Protein: 428-471
Range on HMM: 239-282/319.0
IMDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
.... .     ..||.| .|| ||. |||. ||| |.|...|. 
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 429-472 1.5e-07 25.9 In-house 240-283 (305) alignment 
Range on Protein: 429-472
Range on HMM: 240-283/305.0
MDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
... .     ..| .. .||..|..|||.|.|| |..  . ..|
lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_CG7180_pd Subfamily CG7180 429-475 6.3e-07 23.3 In-house 247-293 (296) alignment 
Range on Protein: 429-475
Range on HMM: 247-293/296.0
MDKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
... .    ...|  | .||..||..|.. |.| ..| ..|. . . 
lelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_PTPN12_pd Subfamily PTPN12 430-477 5.9e-10 33.5 In-house 235-282 (290) alignment 
Range on Protein: 430-477
Range on HMM: 235-282/290.0
DKYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLN
 . .   ....|..||.||.||. .||  ||| . ||.... . ..|.
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_PTPRD_pd Subfamily PTPRD 431-472 1.2e-09 32.4 In-house 240-281 (564) alignment 
Range on Protein: 431-472
Range on HMM: 240-281/564.0
KYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
. ..  . .....| .||.||. |||. ||| |....||. .
rikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_PTPN9_pd Subfamily PTPN9 431-470 3e-06 21.5 In-house 249-288 (297) alignment 
Range on Protein: 431-470
Range on HMM: 249-288/297.0
KYNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILD
. ..    ...  | .||.||  ..|  ||| |||...|.
rleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPRB_pd Subfamily PTPRB 432-473 2.7e-06 21.6 In-house 245-286 (293) alignment 
Range on Protein: 432-473
Range on HMM: 245-286/293.0
YNSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
 ...   ..|.|| .|||.|  .||  .||.| ....|| . 
ieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 433-473 1.6e-08 29.0 In-house 240-280 (288) alignment 
Range on Protein: 433-473
Range on HMM: 240-280/288.0
NSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
..    .....| |||.||. .||.|.|| |.|...|. |.
eeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 433-476 2.4e-06 21.6 In-house 238-281 (315) alignment 
Range on Protein: 433-476
Range on HMM: 238-281/315.0
NSRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRL
. .   ..| .| .||..|| .||  |.| | | ..|.....| 
krtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 433-471 4.4e-06 21.0 In-house 251-287 (325) alignment 
Range on Protein: 433-471
Range on HMM: 251-287/325.0
NSRIDfnLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
.||.|  .|  | |||..|| ||.  .|| ..|... . 
esrvd..ifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Ptp69D_pd Subfamily Ptp69D 434-472 1.2e-08 29.4 In-house 248-286 (307) alignment 
Range on Protein: 434-472
Range on HMM: 248-286/307.0
SRIDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
     ..| .| .||.||. .||.|||| |.|. .|| .
aedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 436-469 2.1e-07 25.0 In-house 308-341 (350) alignment 
Range on Protein: 436-469
Range on HMM: 308-341/350.0
IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTIL
.   .. ||..||.||  |||.|.|..|.|...|
trDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 436-472 1.4e-06 22.5 In-house 223-259 (267) alignment 
Range on Protein: 436-472
Range on HMM: 223-259/267.0
IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
   ..|  ..|.|.||.|.|. .|.|....... .  
gvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 436-472 1.8e-06 22.3 In-house 248-284 (297) alignment 
Range on Protein: 436-472
Range on HMM: 248-284/297.0
IDFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEI
 . ..| .| |||..|| .||  ||| | |...|. .
kevdifglvkklrqerpylvqtkeqykfvyvavleal
0045098 (Phosphotyrosine protein) phosphatases II 437-472 8.7e-07 24.1 In-house 236-272 (278) alignment 
Range on Protein: 437-472
Range on HMM: 236-272/278.0
DFNLFSIVLKLREQRPG-MVQQLEQYLFCYKTILDEI
 ..|...| .||.|||| .|| |||| |.|. .|. .
gvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPRG_pd Subfamily PTPRG 437-477 9.1e-06 19.1 In-house 252-292 (563) alignment 
Range on Protein: 437-477
Range on HMM: 252-292/563.0
DFNLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHRLN
  |.| .. ..| ||. .||. |||.| ....|. |  . .
avnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 439-473 6e-08 27.1 In-house 247-281 (318) alignment 
Range on Protein: 439-473
Range on HMM: 247-281/318.0
NLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIY
..| .| .|||||. |||  .|| |.|...|. . 
Dvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPRK_pd Subfamily PTPRK 439-471 1.3e-06 22.5 In-house 244-276 (314) alignment 
Range on Protein: 439-471
Range on HMM: 244-276/314.0
NLFSIVLKLREQRPGMVQQLEQYLFCYKTILDE
..| .| .||.... ||.  ||| |.|  ||. 
dvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 439-475 6.1e-06 19.6 In-house 243-279 (515) alignment 
Range on Protein: 439-475
Range on HMM: 243-279/515.0
NLFSIVLKLREQRPGMVQQLEQYLFCYKTILDEIYHR
..| .| ..|..|| .||  ||| | | ..|.... |
dvfnfvtnirqkrpylvqtqeqyafiygavledllwr