Gene ptpB in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily ptpB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP047_AA protein Get Run
DdisP047_AA_20-349 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRG_pd Subfamily PTPRG 16-80 9.8e-07 22.3 In-house 10-71 (563) alignment 
Range on Protein: 16-80
Range on HMM: 10-71/563.0
IIEHFNNHPTCIDKEFNFILQKTELRALETDkfrSALEAKNKLKNRYSNVLPFEETRVKINIDDD
... . .  . ...||. . ..|  . |...   .. . .|| ||||.|.......|||..   .
vaslhadgdigfseefealqsetiskdldae...hsqkpenkrKnRylnivaydrsRvklsplpg
0051299 (Phosphotyrosine protein) phosphatases II 17-346 2.7e-81 268.5 In-house 15-284 (288) alignment 
Range on Protein: 17-346
Range on HMM: 15-284/288.0
IEHFNNHPTCIDKEFNFILQKTELraletDKFRSALEAKNKLKNRYSNVLPFEETRVKINiddddddeddneddiivsnnnnnnnnnekrikrnsigssg
 ..  |..| . .||. .|....       ....||  .|. |||||..||.. .|||..                                        
lkllangltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLs........................................

qsdvmsnssdeedhggsGDEGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVK
                   .|   |||||||.|.    . ..|.||||| ||. |||.|.||||...|||||...|. ..||..|||... . ||.. |.
.................vldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvt

FDNNITiPDILIRREFTLENL----KDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE--KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYd
. .  .  |  . |.....||    .|...|...||.||.|||||.| |.. .|.|. .|..   ...||.|||||||.||.|||.|.  ..  . |.. 
llseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeg.

ekkqapSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISE
       ......|  .|. ||||||| .||||.| |. |
......gvdvleavkrlreqRpgmvqtpeqyrfvyealle
0045450 (Phosphotyrosine protein) phosphatases II 17-346 1.9e-75 249.7 In-house 19-302 (307) alignment 
Range on Protein: 17-346
Range on HMM: 19-302/307.0
IEHFNNHPTCIDKEFNFILQKTELRaleTDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDDneddiivsnnnnnnnnnekrikrnsigssg
 .   ...| . |||. .|. |       .....||  .|| ||||...||.. ||||..  |......|                              
llllldfltgllkefekllsvtvfl...lgeysiallpenkdknrykdilpydhtRVklssldgsledsd..............................

qsdvmsnssdeedhggsgdegttlsdYINASFI------------NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE
                          |||||..            .. ..|.||||| .|. |||.|.|||....|||||...|. . ||..||||..||
..........................YiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegee

-RYGNFIVKFDNNITiPDILIRREFTLENL-KDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH--EK--RSGPIVVHCSAGIGRSGTFVAIHSIV
  |||| |.. .  .  | ...| .....| .....|...||.||.|||||.| |.  .|.|.  |..  |.  ..||..||||||.||.|||.|.  . 
ltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

AKFAKHydekKQAPSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISE
  . |.    .  . ..|.. | ..|. |||.||. .||||.| |. |
rqleke....gtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 18-86 1.1e-08 29.5 In-house 10-81 (293) alignment 
Range on Protein: 18-86
Range on HMM: 10-81/293.0
EHFNNHP--TCIDKEFNFILQKTELRALETDK-FRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDD
|.|..|   .. | ...|  .  ||.|...|.   .| .|.|. ||||.|.||....|||..  .|....| 
ekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDY
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 19-85 1.8e-08 28.8 In-house 17-77 (319) alignment 
Range on Protein: 19-85
Range on HMM: 17-77/319.0
HFNNHPTCIDKEFNFILQKTELraletdKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDED
. ..  | ..|||. . . ..       .|.|| . .|| ||||.|.|... |||..   |. .. |
lastgetllekefkllkeavnd......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsd
subfamily_PTPN23_pd Subfamily PTPN23 20-81 7.3e-06 20.0 In-house 10-68 (288) alignment 
Range on Protein: 20-81
Range on HMM: 10-68/288.0
FNNHPTCIDKEFNFILQKTELRaleTDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDD
  .  | .||.|. . || .     . |.  |.  ..  |||. ..||....|||..   ||
mldgktaldkkfkeleqkqdke...arkrsiaiaklyseknrsrdilPyDhnRvklrgskDD
0039614 (Phosphotyrosine protein) phosphatases II 21-349 2.2e-76 252.4 In-house 28-290 (297) alignment 
Range on Protein: 21-349
Range on HMM: 28-290/297.0
NNHPTCIDKEFNFILQKTElraletDkFRSALEAKNKLKNRYSNVLPFEETRVKINIDDddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdv
 | .|....||  .|. ..      | .. ||  .|| ||||...||.. .|||..  |                                         
ansktllllefeellslkp......d.ysiallpenkdknrykdilpydhsrvklkped.........................................

msnssdeedhggsgdeGT-TLSDYINASFIN-----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKtKCDKYWPDKDEeRYGNFIVKFD
                |.   |||||||...     . ..|.||||| .|. |||.|.|||....|||||...|. . ||..|||.. . .||.| |.. 
................gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtll

NNITiPDILIRREFTLENlkDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK----RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHydekkq
. ..  |  ..|.....|  ....|...||||| |||||.| |.. .|.|. .|..      ..||..||||||.||.|||.|.  ..  . |.      
kveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke......

aPSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAMN
   ..... | |.|. |||.||| .||||.| |. |  .
.ggvdvleavkelreqRpgavqtpsqyrflydallellk
0050432 (Phosphotyrosine protein) phosphatases II 22-353 5.6e-88 290.5 In-house 39-304 (308) alignment 
Range on Protein: 22-353
Range on HMM: 39-304/308.0
NHPTCIDKEFNFILQKTElraleTDKFRSALEAKNKLKNRYSNVLPFEETRVKIniddD-Dddeddneddiivsnnnnnnnnnekrikrnsigssgqsdv
. .. ...||. .|....       ....||  .|| ||||...||.. .|||.    | .                                       
ldlglleeefeellsvkp.....lleysvallpenkdkNrykdilpydhsRVkl....deg.......................................

msnssdeedhggsgdegttlSDYINASFINNG------TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK---DEERYGNFIV
                    |||||||...        ..|.||||| ||. |||.|.||||...|||||...|| . ||..|||..   . ..||.| |
....................sdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftv

KFDNNITiPDILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHydekkqa
.. .  .  |  ..|...|.||.|...|...||.||.|||||.| |.. .|.|. .|..  ..||||||||||.||.|||.|.  ..  . |.       
tllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.......

PSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAMNTVLK
  ......|  .|  ||||||| .||.|.| |. | ....|.
ggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0047943 (Phosphotyrosine protein) phosphatases II 22-346 4.8e-78 257.7 In-house 9-270 (273) alignment 
Range on Protein: 22-346
Range on HMM: 9-270/273.0
NHPTCIDKEFNFILQKTElraleTDKFRSALEAKNKLKNRYSNVLPFEETRVKIniDDDDDDeddneddiivsnnnnnnnnnekrikrnsigssgqsdvm
...|.. .||. .|. ..       ... ||  .|| ||||...||.. .|||.  .|...|                                      
lgltllleefelllslkp.....lltysvallpenkdknrykdilpydhsrvkl..gdggsd......................................

snssdeedhggsgdegttlsdYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD---EERYGNFIVKFD
                     |||||...    . ..|.||||| ||. |||.|.||||...|||||...|. . ||..|||..    ...||.|.|.. 
.....................yinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtll

NNITiPDILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH----EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYdekkq
.  |  |  . |...|.||.....|...||.||.|||||.| |.. .|.|. .|..     ...||.|||||||.||.|||.|.. ..  . |..     
seet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg.....

apSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISE
   ......|  .|. ||||||| .||||.| |. |
..gvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 22-85 7.8e-07 23.5 In-house 14-80 (297) alignment 
Range on Protein: 22-85
Range on HMM: 14-80/297.0
NHPTCIDKEFNFILQKTELRALETDKFRSALEAKNK---LKNRYSNVLPFEETRVKINIDDDDDDED
. .| ..|. .  . . |.. | . . ...  |..|    |.||.|.||..  |||..| .|| | |
dfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsD
subfamily_PTPRD_pd Subfamily PTPRD 24-85 1.6e-07 25.4 In-house 309-367 (564) alignment 
Range on Protein: 24-85
Range on HMM: 309-367/564.0
PTCIDKEFNFILqktELRALETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDED
 | ...||. .      .  |...| .| . ||| |||.||.|..|..||...   .... |
mtgleleFqrLa...takeieleefavatkpknkkknrfsnilalescrvvlsairakeesd
0040438 (Phosphotyrosine protein) phosphatases II 25-372 1.7e-81 269.3 In-house 18-300 (317) alignment 
Range on Protein: 25-372
Range on HMM: 18-300/317.0
TCIDKEFNFILQKtelralETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsns
| . .||. .|.         | .. |.  .|| ||||...||.. .|||..                                                
talleefedllsl......kldtysvaelpenkdknrypdilpydhsRVkLsp...............................................

sdeedhggsgDEGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITiP
          ..|   |||||||...    . ..|.||||| ||. |||.|.|||....|||||..||. . ||..|||....  ||.|.|.. . ..  
..........lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.l

DILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE--KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYdekkqapSINLPK
.  . |....|.|.|...|...||.||.|||||.| |.. .|.|...|..   ...||..||||||.||.|||.|.  ..  . |..        .....
agitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.......gvdvee

LVVEMRNERPGMVQTRDQYRFCYLAISEAMNTVLKKEQKKRKGLSYSYSSIPLT
 | |.|. |||.||| .||||.| |. | ....|..|  ... | . .  |||.
avkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipla
0036941 (Phosphotyrosine protein) phosphatases II 25-351 2.2e-81 268.7 In-house 13-280 (297) alignment 
Range on Protein: 25-351
Range on HMM: 13-280/297.0
TCIDKEFNFIlqkteLRALETDKFRSALEAKNKLKNRYSNVLPFEETRVKIniddD--Dddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvms
... |||  .     |. |   ... ||  .|. ||||...||.. ||||.    |  .                                         
alllkefeel.....lpllllgslsvallpenleknRykdilpydhtRVkl....ddeg.........................................

nssdeedhggsgdegttlSDYINASFINNG----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK--DEERYGNFIVKFDNN
                  |||||||...      ..|.||||| ||. |||.|.||||...|||||...|. . ||..|||..  ..  ||.|.|.. . 
..................sdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsv

ITI-PDILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK----RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHydekKQA
 ..  |  ..|............|...||.||.|||||.| |.. .|.|. .|..      ..||..||||||.||||||.|.  ..  . ..    .  
evvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledk....lke

PSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAMNTV
. ......| ..|. |||.||| .||||.| |. |  ...
ggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPN6_pd Subfamily PTPN6 25-98 3.4e-07 24.6 In-house 26-95 (306) alignment 
Range on Protein: 25-98
Range on HMM: 26-95/306.0
TCIDKEFNFiLQKTELRALETDkfRSALEAKNKLKNRYSNVLPFEETRVKINiDDDDDDEDDNEDDIIVSNNNN
. . .||.  ||..| . | .   . .  ..|| |||| |.|||..|||... ...  ..|  . ..| .. ..
agfeeefee.lqqeeakkllsr..kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 25-85 1.3e-06 22.9 In-house 27-85 (298) alignment 
Range on Protein: 25-85
Range on HMM: 27-85/298.0
TCIDKEFNFILQKTElrALETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDED
|  ..||. . . ..   .|... . | . .|| ||||....... .|| .. .|.|.. |
tgyalefqrlnsvss..eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesd
0043336 (Phosphotyrosine protein) phosphatases II 26-345 1.4e-75 249.7 In-house 21-274 (278) alignment 
Range on Protein: 26-345
Range on HMM: 21-274/278.0
CIDKEFNFILQKTElraletDKFRSALEAKNKLKNRYSNVLPFEETRVKINIddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnss
.. .||  .|. .       | .. ||  .|| ||||...||.. .|||..                                                 
llllefeellsfkl......dtysiallpenkdknrykdilpydhsrvklsl................................................

deedhggsgDEGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPdKDEERYGNFIVKFDNNITiPD
         ..|   |||||||...    . ..|.||||| .|. |||.|.||.....|||||...|. ..||..||| .. ..||.| |.. . ..  |
.........lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.ld

ILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE--KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYdekkqapSINLPKL
  ..| ....||.|...|...|..|. |||||.| |.. .|.|. .|..   ...||..||||||.||.|||.|.  ..  . |..        ..|.. 
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.......gvdleea

VVEMRNERPGMVQTRDQYRFCYLAIS
| |.|. |||.||| .||||.| |. 
vkelreqRpgavqtpsqyrflyeall
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 26-85 1e-07 26.4 In-house 21-75 (318) alignment 
Range on Protein: 26-85
Range on HMM: 21-75/318.0
CIDKEFNFILQKTElralETDKFRSaLEAKNKLKNRYSNVLPFEETRVKINIDDDDDDED
 ...|.. . ...|    .. ...| ||  || |||| |.|....||||..  ... . |
llseeyerlsrsee....tvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsD
DSPc_SM00195 27-348 1.1e-97 321.9 In-house 2-262 (263) alignment 
Range on Protein: 27-348
Range on HMM: 2-262/263.0
IDKEFNFILQKTELRaletdKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssd
...||. ....|. .     ....| . ||| ||||.|.||...||||.. ....                                             
lkeefekleestspk.....etteaekkknksknRyknilpydhtrVklkkeekk.............................................

eedhggsgdegtTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK--DEERYGNFIVKFDNNITIP
            . ||||||..|.      .||.||||| .|. |||.|.||....||||||.|||| |.|||.|||..  ..|..|.. ||. .... .
............egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk

DILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKR--SGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDekkqapsINLPK
| .|.|...|.. ....|||....||..|||||.| ||. .|.....|...|.  |||||||||||.||.||||.|..|. |.... .       ... .
deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.......vdife

LVVEMRNERPGMVQTRDQYRFCYLAISEAM
.| |.|..|||||||..||.|.| || |..
ivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 27-348 1.1e-97 321.9 In-house 2-262 (263) alignment 
Range on Protein: 27-348
Range on HMM: 2-262/263.0
IDKEFNFILQKTELRaletdKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssd
...||. ....|. .     ....| . ||| ||||.|.||...||||.. ....                                             
lkeefekleestspk.....etteaekkknksknRyknilpydhtrVklkkeekk.............................................

eedhggsgdegtTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK--DEERYGNFIVKFDNNITIP
            . ||||||..|.      .||.||||| .|. |||.|.||....||||||.|||| |.|||.|||..  ..|..|.. ||. .... .
............egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk

DILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKR--SGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDekkqapsINLPK
| .|.|...|.. ....|||....||..|||||.| ||. .|.....|...|.  |||||||||||.||.||||.|..|. |.... .       ... .
deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.......vdife

LVVEMRNERPGMVQTRDQYRFCYLAISEAM
.| |.|..|||||||..||.|.| || |..
ivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 27-77 3.5e-06 21.0 In-house 12-59 (287) alignment 
Range on Protein: 27-77
Range on HMM: 12-59/287.0
IDKEFNFILQKTelrALETDKFRSALEAKNKLKNRYSNVLPFEETRVKINI
.|||.. . . .      |  |..| |  .  ||||..|||...||| .  
vdkevdalkeds...esstatfkaaeelaavkknryadvlPiddtrvllsa
0046845 (Phosphotyrosine protein) phosphatases II 28-85 2.1e-07 26.1 In-house 3-57 (284) alignment 
Range on Protein: 28-85
Range on HMM: 3-57/284.0
DKEFNFILQKTELRAletDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDED
..||  .|. |  .     ... ||  .|. ||||...||.. .|||..  |.|....
eeefeellsltvkll...lslsvallpenlsknRykdilpydhsRVklksldgdleds
subfamily_PTPN12_pd Subfamily PTPN12 29-92 1.1e-06 22.7 In-house 12-76 (290) alignment 
Range on Protein: 29-92
Range on HMM: 12-76/290.0
KEFNFILQK-TELRALETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDDNEDDII
|||. . .  ....| .. .  .. . .|. |||| ..||....||... .......|    ..|
kefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 35-352 6e-71 233.8 In-house 19-280 (281) alignment 
Range on Protein: 35-352
Range on HMM: 19-280/281.0
LQKTELRALETDKFRSALE-AKNKLKNRYSNVLPFEETRVKINIDDDDDdeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggs
 . ..|.|...|.  .| .  .|.|||||||.  .. ||||.. ....                                                    
eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk...................................................

gdegttLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD-EERYGNFIVKFDNNITIPDiLIRREF
       .|||||.|..    .  || ||||. ...|.||.|.|||. ..|||.||| |. | || .||||.. | .||...||. .. . .   |.|.|
......ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekat.yierkf

TLeNLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV--DHEKR-SGPIVVHCSAGIGRSGTFVAIHSIVAKFAkhydekKQAPSINLPKLVVEMRN
.| . ....||.. ...||.||||| | .|. .|.| . |   .||.   |.|.|||||.||.||..|.  .| . .      ........  .| |.|.
kl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave......aeleeldvkavvaelrk

ERPGMVQTRDQYRFCYLAISEAMNTVL
||  ||||  ||.| |.|. .|..  |
ernlmvqtvvqyefvykavldaldkel
subfamily_PTPN13_pd Subfamily PTPN13 40-76 2.6e-06 21.9 In-house 20-57 (273) alignment 
Range on Protein: 40-76
Range on HMM: 20-57/273.0
LRAL-ETDKFRSALEAKNKLKNRYSNVLPFEETRVKIN
|| |  .|. ... ...|| |||| ||||..|||||..
lrelkpldtcevgkkkenkdknryrnvlPydetrvklg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 40-86 7.9e-06 20.1 In-house 30-77 (288) alignment 
Range on Protein: 40-86
Range on HMM: 30-77/288.0
LRALE-TDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDD
| ||| |..   . .|.|. |||| |.||..|.|||..  .. ...| 
LaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDY
0049772 (Phosphotyrosine protein) phosphatases II 41-353 3.5e-40 134.0 In-house 31-285 (314) alignment 
Range on Protein: 41-353
Range on HMM: 31-285/314.0
RALETDKFRSALEAKNKLKNRYSNVLPFEeTRVKINIDDDdddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdEGttl
..|    .  |   .|. |||| ..||.. .||...  .                                                        .|   
svlpeltilvadlflnrdknryldilpad.nrvilpglpv.......................................................sg...

SDYINASFINN-GTYICTQGPLLNTIVDF----------WKMI--WEQNSNIIVM---------------------LTREEENFktkcdKYWPDKDEERY
|||||||....  ..|.||||| .|.|||          |.|.  ...|. .|||                     |..  .|.      ... .| | .
sdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlell

GnfivkfdnnitipdilirrefTLENLKDNKTRKIYHFQYTTWPDHGTPvSTTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakHyd
                      .  . ..  .| .... .. .||...| ..  |..|. |..  .. ||..|||.||.||.||||..  .. ..  .  
k.....................eelydpelferlgikylripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll..g..

ekkqapsINLPKLVVEMRNERP-----GMVQTRDQYRFCYLAISEAMNTVLK
       ..| . . ..|. ||     |.... .|| |.. |. |......|
.......vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 43-87 2.8e-07 24.7 In-house 31-75 (315) alignment 
Range on Protein: 43-87
Range on HMM: 31-75/315.0
LETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDDN
 .. . |.| |  |  |||| |.||....|||... ||. |.|  
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 44-98 1.6e-06 21.8 In-house 33-87 (392) alignment 
Range on Protein: 44-98
Range on HMM: 33-87/392.0
ETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDDNEDDIIVSNNNN
.  . ..| .  |. |||| |.||....|||... ||  |.|  .   | | .|.
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne
0045098 (Phosphotyrosine protein) phosphatases II 46-347 3e-75 248.4 In-house 23-271 (278) alignment 
Range on Protein: 46-347
Range on HMM: 23-271/278.0
DKFRSALEAKNKLKNRYSNVLPFEETRVKiniddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdegttlsDYIN
...  ||  .|. ||||...||.. .|||                                                                   ||||
seitpalylgnldknRykdilpydhsrVk...................................................................dYIN

ASFIN--NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIpDILIRREFTLENL----KDNKTR
||.|.  . ..|.||||| .|. |||.|.||.....|||||...|. . ||..|||... ..||.| |.. .  .. |  . | ....||    .|...|
AsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesr

KIYHFQYTTWPDHGTPVST--TGFLKFVSFVDHEK---------------RSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKqaPSINLPKLVVE
...|..|..|||||.| ..  . ||... |...                 ..||..||||||.||.||.||.. .   .       .  . ..|.. | |
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.......e..ggvdlleavke

MRNERPG-MVQTRDQYRFCYLAISEA
.|. ||| .||. .||||.| .. | 
lrsqRpglavqnleqyrflyefllel
subfamily_egg_pd Subfamily egg 48-349 2.3e-22 74.0 In-house 32-271 (307) alignment 
Range on Protein: 48-349
Range on HMM: 32-271/307.0
FRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdegttlsDYINAS
.. |... |. | |   |   . .|||...      .                                                         |.| | 
lttaasdnnlekarskrvhckdssrvklelrrGqyld.........................................................dfihan

FINNG----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENfkTKCDKYWPDKDEE--RY--GNFIVKFDNNITIPDILIRRE-FTLeNLKDNKT
 .. .    ..|..| || ||  |||.|..... . |||||   |.   .|. |||  ...  ..  |.. ..  .    .| | |   . |    |.. 
rvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddee

RKIYHFQYtTWPDHGTPVSTTGFLKfvsfvDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHyDEKKQapsiNLPKLVVEMRNERPGMVQTRDQYR
| . |.|.  .   .   |    |.        . | |.||..  |. ...|.|||   . .. .     |.     . . || .| .|.  |..  .| 
rflehwqg.dvnnssdvysplrvlr.....klrnlskpvvvqdilGvskaatlvaieiallsllrG.pitks....lvlravvflrlrrrlsvesvllyl

FCYLAISEAMN
| |  .   . 
fvyrlvlfffr
0040439 (Phosphotyrosine protein) phosphatases II 49-346 1.4e-71 236.3 In-house 4-244 (249) alignment 
Range on Protein: 49-346
Range on HMM: 4-244/249.0
RSALEAKNKLKNRYSNVLPFEETRVKINIddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgDEGTTLSDYINASF
. ||  .|| ||||...||.. .|||..|                                                          .|  ||||||||.
svallpenkdknrypdilpydhsrvklsi.........................................................lpglflsdyinAsy

IN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDiLIRREFTLENLKDNKTRKIYHF
|.    . ..|.||||| .|. |||.|.||.....|||||...|. . ||..|||....  ||.| |.. . .. .| ...|...|.||.|...|...|.
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkdd.ytvrtleltnlydgesrtvlhi

QYTTWPDHGTPVSTTGFLKFVSFVDHEK----RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDekkqapsINLPKLVVEMRNERPGMVQTRDQYRFC
||| |||||.| |.  .|.|.  |..      ..||..||||||.||.|||.|.  ..  . |...       ..|.  | ..|. |||.||. .||||.
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg.......vdleeavkllrsqRpgavqnpeqyrfl

YLAISE
| |. |
yealle
0037934 (Phosphotyrosine protein) phosphatases II 49-346 4.4e-69 228.0 In-house 3-240 (243) alignment 
Range on Protein: 49-346
Range on HMM: 3-240/243.0
RSALEAKNKLKNRYSNVLPFEETRVKIniddddD-DeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdegttlsDYINAS
. ||   |. |||||..||.. .|||.      . .                                                          |||||.
siallpenlsknrysdilpydhsrvkl......egs..........................................................dyinan

FIN-NGTYICTQGPLLNTIVD----FWKMIWEQNSNIIVMLTREEENFKTKCDKYWPdkDEERYGNFIVKFDNNITIPDiLIRREFTLENLK-DNKTRKI
.|.  ...|.||||| .|. |    ||.|.||.....|||||...|. . ||..|||  .|..||.|.|.. .  . .|  . |...||||. |. || .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehldd.ytvrtlllenldlddltrlv

YHFQYTTWPDHGTPVSTTGFLKFVSFVD----------HEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekkqapSINLPKLVVEMRNERPG-M
.|..|. |||||.| |.. .|.|...|           .....||..||||||.||.||..|.  .  ..           ...| . | ..|. ||| .
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...........gvdleeavkllreqRpgka

VQTRDQYRFCYLAISE
|||..||||.| |. |
vqtpsqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 50-346 1.5e-70 232.7 In-house 3-241 (245) alignment 
Range on Protein: 50-346
Range on HMM: 3-241/245.0
SALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDdneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdegttlsdYINASFI
.||  .|| |||||..||.. ||||.. |. | | |                                                         |||||..
vallpenkdknrysdilpydhtrvklspdggdldsd.........................................................yinasyv

----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITiPDILIRREFTLENLKDNKTRKIYHFQ
     ....|.||||| .|. |||.|.||.....|||||.|||. . ||..|||.... .||.|.|.. .  .  | ...|.....||.|...|...|..
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyh

YTTWPDHGTPVSTTGFLKFVSFVDH---EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYdekkqapSINLPKLVVEMRNERPGMVQTRDQYRFCYL
|. |||||.| ..  .|.|..||..   |...||..||||||.||.|||.|.  ..  . |..        ..|.. | |.|. |||.||| .||||.| 
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekel.......gvsleeavkelrsqRpgavqtpsqyrflye

AISE
|. |
alle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 51-254 3.8e-18 60.0 In-house 34-235 (244) alignment 
Range on Protein: 51-254
Range on HMM: 34-235/244.0
ALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDDNEDDIIVSNNNNNNNNNEKRIKRNSIGSSGQSDVMSNSSDEEDHggSGDEGTTLSDYINASFIN
|. . |  |||| |.|||.|||| ..    .  .  | . |  |.|    . .  .   |   |  . .  .   | .       .|.    ||||||. 
avlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrv..plskgsmgntyinasfvg

----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENfktkcDKYWPDKDE-ERYGNFI-VKFDNNITIPDILIrREFTLENLKDNKTRKIYHF
       || || || .| .|||||. |.  |..|.|   ||.     |.|||| .  | | . | | . .   . .|    .. .|   ..  . .  |
clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknika.snleiesdmneshqaltmf

QYTTWPDHGT
| . ||  ||
qisnwpsdgt
Spore_III_AF Stage III sporulation protein AF (Spore_III_AF) 53-127 2.1e-06 14.1 Pfam-A 87-163 (188) alignment 
Range on Protein: 53-127
Range on HMM: 87-163/188.0
EAKNKLKNRYSNVLPFEETRVKINIDDDDDDED--DNEDDIIVSNNNNNNNNNEKRIKRNSIGSSGQSDVMSNSSDE
. ....... ..  . .. .|....... ...    .| .. |...........|..|. .||.. .|.  ......
rlekqieellkleygiktvdvevevaeeqesrkfaikevvvtvkeaetgktktgkkvkpvaigqeaeskpgaeeats
Y_phosphatase Protein-tyrosine phosphatase 56-345 2.9e-76 251.4 Pfam-A 1-234 (235) alignment 
Range on Protein: 56-345
Range on HMM: 1-234/235.0
NKLKNRYSNVLPFEETRVKIniddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgDEGTTLSDYINASFI----NN
|| ||||...||...||||.                                                           .. .. ||||||...    ..
nkkknRykdilpydktrvkl...........................................................kgsegpsdYInAnyvkgykek

GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWP--DKDEERYGNFIVKFD-NNITIPDILIRREFTLENLKDNK-TRKIYHFQYT
 ..|.||||| .|| |||.|.|......|||||..||. ..||..|||  ......||.. |.   .. .. .  . |...|.. |... .|......||
kkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhyt

TWPDHGTPVSTTGFLKFVSFVDHEK--RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydEKKqapsINLPKLVVEMRNERPGMVQTRDQYRFCYLAIS
.|||||.| |....|...  | ..|  .|||.|||||||.||.|||||.  .. .. .   |..    ... ..| |.|..||||||. .|| |.| || 
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea...eee....vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 56-345 2.9e-76 251.4 In-house 1-234 (235) alignment 
Range on Protein: 56-345
Range on HMM: 1-234/235.0
NKLKNRYSNVLPFEETRVKIniddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgDEGTTLSDYINASFI----NN
|| ||||...||...||||.                                                           .. .. ||||||...    ..
nkkknRykdilpydktrvkl...........................................................kgsegpsdYInAnyvkgykek

GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWP--DKDEERYGNFIVKFD-NNITIPDILIRREFTLENLKDNK-TRKIYHFQYT
 ..|.||||| .|| |||.|.|......|||||..||. ..||..|||  ......||.. |.   .. .. .  . |...|.. |... .|......||
kkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhyt

TWPDHGTPVSTTGFLKFVSFVDHEK--RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydEKKqapsINLPKLVVEMRNERPGMVQTRDQYRFCYLAIS
.|||||.| |....|...  | ..|  .|||.|||||||.||.|||||.  .. .. .   |..    ... ..| |.|..||||||. .|| |.| || 
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea...eee....vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 56-350 2.8e-61 202.0 In-house 28-270 (274) alignment 
Range on Protein: 56-350
Range on HMM: 28-270/274.0
NKLKNRYSNVLPFEETRVKINIDDDDddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdegTTLSDYINASFIN-----
.. |||| ..|| |..|| .. .. .                                                          .|.|||| .|      
sqtknryktilPnensrvllesesse........................................................dedssyinanyikGydee

NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE----RYGNFIVKFDNNITIPDILIRrEFTLENLKDnkTRKIYHFQY
. .|. ||||| ||. |||.||.......|||||. .|. ..|| .|.||. .     |||.. .|... ..  |  .| ...|..|..  .|...|. |
skayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvr.klvlkyler..ersvkhywy

TTWPDHGTPVSTTGFLKFVSFVDHEK-----RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydekkqAPSINLPKLVVEMRNERPGMVQTRDQYRFCY
| |||| .| ... .|..|  |....     . .|.|||||||||| | |.||.  | .. .          ... |.|...| .| |||||..||.. .
tdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.......eivvdvlkivcnlrldrGGmvqtseqyelih

LAISEAMNT
 |... .. 
ralclylkr
0041856 (Phosphotyrosine protein) phosphatases II 56-348 7.6e-48 157.8 In-house 1-171 (182) alignment 
Range on Protein: 56-348
Range on HMM: 1-171/182.0
NKLKNRYSNVLPFEETRvkiniddddddeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdegttLSDYINASFIN----N
|. |||||..||.. .|                                                                    .|||||...     .
nldknrysdilpydhsr...................................................................dldyInanlylgslpa

GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTreeenfktkCDKYWPdkdeerygnfivkfdnnitipdilirreftlenlkDNKTRKIYHFQYTTWPD
 ..|.||||||.|. ||..|..|.. ..||.||         .. |||                                   .. .| .....|. |||
trfiatqgpllstvadflrmlkelgittivnlt.........eelywp...................................ellerlgiqylylpwpD

HGTPVsTTGFLKFVSFVDHekRSGPIVVHCSAGIGRSGTFVAIHSIVAKfakhydekkqapSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAM
||.|  .  .|.|.  | .  ..||..||||||.||.||.||.  .  .            ...|.. | ..|. |||||.| .||.|..||. | .
hgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl............gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 57-215 2.8e-19 64.0 In-house 48-164 (350) alignment 
Range on Protein: 57-215
Range on HMM: 48-164/350.0
KLKNRYSNVLPFEETRVKINIDDDDDdeddneddiivsnnnnnnnnnekrikrnsigssgqsdvmsnssdeedhgGSGDEGTTLSDYINASFINNG----
  ||||.|.||.| .|||..                                                        . .  .  .|||||....      
faknrYknilPYehsrvkLkkslkss.................................................dakkhslstnDYinanYlkltrfsv

------TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDeerYGNFIVKFDN
       || ||.|| .|. ||.|.| . . ..|..|| . |.   ||..||.. .   | .. ||. .
einpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs...ydditvklas
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 57-216 8e-14 45.7 In-house 49-168 (349) alignment 
Range on Protein: 57-216
Range on HMM: 49-168/349.0
KLKNRYSNVLPFEETRVKINIDDDDDDEddNEDDIIVSNnnnnnnnnekrikrnsigssgqsdvmsnssdeedhggsgdeGTTLSDYINASFIN------
  ||||...||.| .|||..           .     |.                                         .. | ||||| ...      
faknrykdilPyehsrvklkkslksskv..ikastsesd.........................................sgklddyinanylkltrisv

NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWpdkDEERYGNFIVKFDNN
.  ||.|| ||  |. ||.|.|  .. .... |. ..|.   |||.||   .|  | |. ||. | 
ekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw...qelsysnitvklqns
DUF2457 Protein of unknown function (DUF2457) 69-143 4.5e-06 12.9 Pfam-A 47-122 (458) alignment 
Range on Protein: 69-143
Range on HMM: 47-122/458.0
EETRVKINIDDDDDDEDDNEDDIIVSNNNNNNNNNEKRIKRNSIGSSGQSDVMSNSSDEEDH-GGSGDEGTTLSDY
||   . . |.||...||..|.    ............   .|     .|.   | .|.|   . | ||  . |||
eealeeedededdeedddddDeddddedddeddeddelddddstladassaddGnetdneagfaeSdDesddgsdy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 83-264 7.4e-28 92.2 In-house 7-189 (297) alignment 
Range on Protein: 83-264
Range on HMM: 7-189/297.0
DEDDNEDDIIVSNNNNNNNNNEKRikRNSIGSSGQSDVMSNssdeEDHGGSGDEGTTLSDYINASFIN------NGTYICTQGPLLNTIVDFWKMIWEQN
 | ..| |... ... ..    ||   .|. .    |...     .|       . | .||||| ..       .  ||..|||| .|. |||....||.
keleaekdllldeargesfssakr..nsslrknryrdilat....ddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqd

SNIIVMLTREEENFKTKCDKYWPDKDEERY--GNFIVKFDNNITI--PDILIrREFTLENLkdNKTRKIYHFQYTTWPDHGTPVSTTGFLKF
 ..|||... .|. . ||  |||. ..||   |...|.|  . .     . .  |..|     ...|.. | |. .||||| |       .|
vrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 126-181 2.7e-06 21.1 In-house 58-114 (347) alignment 
Range on Protein: 126-181
Range on HMM: 58-114/347.0
DEEDHGGSGDEgttLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIV
 |. . .  |.      ||||| |.    .  || || || .|. |||||.   .   .|
peksknsradd...vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 127-345 8.8e-49 160.9 In-house 57-263 (283) alignment 
Range on Protein: 127-345
Range on HMM: 57-263/283.0
EedhggsgdegttlsDYINASFIN-------NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITI
.              |||||.||        .  || .|.|| .|.||||||.....   |||||.  |. . || .||| .  | ||.| |   .. | 
r..............dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrketts

pDILIRREFTLENL-KDNKTRKIYHFQYTTWPDHGTPVSTTGFLKF--VSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVakfakhyDEKKQAPSINL
 . .|..|..| .    ..|  . |.|.  | . |       ..||  |     |.. ||||||||.||||...|.|. . |       .. .    ...
.nsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasv.......kdaltesvvdv

PKLVVEMRNERPGMVQTRDQYRFCYLAIS
.. |  ||..|...|||.|||.. . .. 
favvkimreqrmmavqtldqyklvhelvl
subfamily_PTPRG_pd Subfamily PTPRG 134-350 5.2e-60 198.2 In-house 71-289 (563) alignment 
Range on Protein: 134-350
Range on HMM: 71-289/563.0
GDEGTTlsDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIP----DILIR
| ...   |||||..|.    .  .| ||||| .|. |||.||||||..||||.|  .|. . ||| |||  . |.||.. |.  .. ..       |. 
gkkkkl..DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlvi

REFTLENLKD-NKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRS--GPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVE
... |.. |. .. .......||.|||||.| ...  |.||   .  ...  ||||||||||.||.||.... ... .        .|  ..|. ...  
knlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqi.......qqenavnvfgflkh

MRNERPGMVQTRDQYRFCYLAISEAMNT
.| .|. .|||..|| | . |. ||...
iraqRnflvqteEqYiflhdalleaias
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 135-350 7.2e-63 207.6 In-house 68-285 (305) alignment 
Range on Protein: 135-350
Range on HMM: 68-285/305.0
DEGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE--RYGNFIVKFDNNITIPDILIRrEF
.| .  |||||||...    . .|| .|||| ||..|||..|.|   . |||||.  |. | || .|||..  |  ..|.|.|.  .. |..| ..| ..
keslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieR.kl

TLEN-LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRSG---PIVVHCSAGIGRSGTFVAIHSIVakfakhyDEKKQAPSINLPKLVVEMR
.. .  .|...| . ..| |.||||| | ..| .|...  | ......   |..||||||.||.|.|.|..  .       .  |.  .... ... ..|
kisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdial.......erlkkEevvdvfevlkqlR

NERPGMVQTRDQYRFCYLAISEAMNT
..|..|||| ||| |.. |. | ...
skrmkmvqtldqYvflhdaldelitc
subfamily_PTPRD_pd Subfamily PTPRD 136-351 8e-80 264.0 In-house 71-284 (564) alignment 
Range on Protein: 136-351
Range on HMM: 71-284/564.0
EGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDILIrREFTLE
||.  |||||||||.    . .|| ||||| .|| |||.|.|||||..|||||. ||. |.||.||||.|..|.||...|.. .. .. |. | |.|.|.
egdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyei.rtfklk

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH--EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydEKkqapSINLPKLVVEMRNERPG
. |....|.. .|..| ||||| | |.|..|.... | .  |. .||||||||||.||.|||..|.... .  .   ||     ... . | ..|..|. 
kkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike...ek....tvDiyqyvkalrkqRna

MVQTRDQYRFCYLAISEAMNTV
||||..|| |.. || ||..  
mVqteeQYiFiheailealacg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 136-352 1.5e-69 229.5 In-house 69-284 (318) alignment 
Range on Protein: 136-352
Range on HMM: 69-284/318.0
EGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDILIrREFTLE
||.. ||||||..|.    . .|| .|.|| .|| |||.|.||||| .|||||.|||. |.|...|||.|. . ||.  |. ...... | .. |||...
egeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvl.refkvt

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH---EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERP
. . ...|..  ..||.|||.|.| |....|..|  |..   ..  ||||||||||.|| |.|.|. ... .        |.   ... . | ..|..|.
rteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdilleri.......kaealvDvfqtvkqlreqrn

GMVQTRDQYRFCYLAISEAMNTVL
 ||||.||| |.| .. ||...  
lmvqtedqyefiydvllealasgd
subfamily_PTPN6_pd Subfamily PTPN6 136-350 5e-65 214.5 In-house 76-299 (306) alignment 
Range on Protein: 136-350
Range on HMM: 76-299/306.0
EGTTLSDYINASFIN------NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD-EERYGNFIVKFDNNITIPDIlIRREF
.... ||||||..|.      . .|| ||| | .|. |||.|.|..||..|||.|.| |  | || .||||.  .|.||.  |.  .. .  |  | ||.
psvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladY.ilRel

TLE-NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK------RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAkhydEKKQAPSINLPKLVV
... . |....|.........|||||.| ..  .|.|.. |....      ..||||||||||||| |||. |  .. .      .|.    |.. ||| 
svskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie....kkgldadidiqklvk

EMRNERPGMVQTRDQYRFCYLAISEAMNT
 .|. | |.||| .||.| | ||.. ..|
svreqrsglvqteqqykfvykaikkyiet
subfamily_PTPRA_pd Subfamily PTPRA 136-347 5.6e-61 201.2 In-house 81-294 (330) alignment 
Range on Protein: 136-347
Range on HMM: 81-294/330.0
EGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDILIRrEFTLE
||.  |||||||||.      ..| .|||. .|. |||.|||||.|  |||||  .|  ..|| .||||.    |||  |. ...  . |. .| .| ..
eGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvr.kflvq

N----LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE--KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhYDEKKqapsINLPKLVVEMRN
.     ...|.| .  | .|.||| | |. . | ||..  | .   . .||||||||||.||.|||... .....      |.|    ... . | ..|.
qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlerv...kaerk....vdvfefvkrlrl

ERPGMVQTRDQYRFCYLAISEA
 || ||||  || |.| .. | 
qrpqmvqtdeqyefiykvlley
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 136-351 3.5e-59 195.0 In-house 32-245 (250) alignment 
Range on Protein: 136-351
Range on HMM: 32-245/250.0
EGTTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTkCDKYWPDKDEERYGNFIVKFDNNITIPDILIrREFTLE
.|   ||||||||..      ..| ||||| .||.|||.|..|..|. |||||  .|. || . .||| .  |.||.  |.  .. .  |. . |.. | 
kgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadytk.rklkls

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRS---GPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERP
. | .. | . ......||| | |  .|  |.... |  ...    .|..|.||||.||||.|.||.... .        |.   ... |..  .|..||
kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl.......kkekvvdvfkvikvlrkdrp

GMVQTRDQYRFCYLAISEAMNTV
..|....|| |.| .| .|...|
havesleqyvfvyeiilkaldsv
subfamily_PTPRK_pd Subfamily PTPRK 136-348 1.4e-58 193.2 In-house 66-277 (314) alignment 
Range on Protein: 136-348
Range on HMM: 66-277/314.0
EGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEErYGNFIVKFDNNITIPDIlIRREFTLE
.| . ||||||..|.       .| ||||| .|. |||......|.  |||||   |... || ||||.. |  ||.. |.. .  .  .. . | |..|
dgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellael.vvrifrve

N--LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH--EKRSGPIVVHCSAGIGRSGTFVAIHSIVaKFAkhydekKQAPSINLPKLVVEMRNER
.   . ...|.. .||...||||..||| ||.||.|  |..  |.. |.|||||||| ||.|||.||....   .      ..   ... . | ..|...
klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl.dmi......eregvvdvfnavktlrsrk

PGMVQTRDQYRFCYLAISEAM
. ||.| .||.|.| .| || 
vnmveteeqykfiydvileac
subfamily_PTPN9_pd Subfamily PTPN9 136-346 2.1e-56 186.1 In-house 65-288 (297) alignment 
Range on Protein: 136-346
Range on HMM: 65-288/297.0
EGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPD--KDEERYGNFIVKFDNNITIPDiLIRREFT
.... ||||||.|..    . ..| ||||| .|. |||.|.|||.  .||| || .|. . || .|||.  .. ...|.. |.  .  .  |    | ..
dedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvle

LENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE---------------KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSI
..| |....||. |||...|||.|.| |.. .|.... | ..                .  ||||||||||||.|||...   ....       ..   .
iknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl.......eevgtv

NLPKLVVEMRNERPGMVQTRDQYRFCYLAISE
.. . |  .|. |  ..|| .|| |||||. |
dvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 136-347 1.7e-45 150.0 In-house 60-276 (287) alignment 
Range on Protein: 136-347
Range on HMM: 60-276/287.0
EGTTLSDYINASFI----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE-RY-GNFIVKFDNNITIPDiLIRREFT
||   |||||| ..    .. ..|..|||.  |. |||....|..|  ....||| |. . || ||||...   |  |  .| .| .|  |.    | . 
egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePe.ygvralr

LENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV-D------HEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVE
| .|. ...| .  ... .|||.. . .. |...||  | .        .  ||.|||...||||||...|.  .| .        ..   ..  . |. 
lidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl.......edlGrvdvaavvir

MRNERPGMVQTRDQYRFCYLAISEA
.|. | ..||.  |.|. | |.   
lreyraalvqavvqlrllyealvty
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 136-344 9.9e-45 147.6 In-house 28-235 (237) alignment 
Range on Protein: 136-344
Range on HMM: 28-235/237.0
EgttlSDYINASFINN-----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDE-ERYGNFIVKFDNNITIPDILIRREFT
.    ||||||.....      .||..|||| ..  |||.|.|...  .|||||   |. . || ||||. |. . || . | .  .  . |  .|   .
g....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslll

LENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSF----VDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKfAKhydEKKQapsINLPKLVVEMRN
 ..|. .. | |. .|.|.|||.| |  |. .|.|         |  .||| ..|||||.||.| |. | ... . ||   |||    ... . |  . .
skrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq.ak...ekkv...vdiynyvysiee

ERPGMVQTRDQYRFCYLAI
.|| ..||.||| | . .|
drpyiiqtkdqyvfihqti
subfamily_CG7180_pd Subfamily CG7180 136-348 1.7e-43 143.3 In-house 65-290 (296) alignment 
Range on Protein: 136-348
Range on HMM: 65-290/296.0
EGTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKtKCDKYWPDKDEERYGNFIVKFDNNITIPDILIRrEFTLE
.|   ||||||....    .  || |..|  .|. .||......... .|.||.. .  | .. .||| | .|.||...|.  .. . ... || .| | 
dGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkir.tfklt

NL----------KDNKTRKIYHFQYTTWPD-HGTPVSTTGFLKFVSFVDH-------EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPS
             . .|| . .||.|.|.  .  |.||.......  |         ..  ||.||..| | .||| ..||   . .        ..   
kkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelv.......ekeee

INLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAM
... . |  .|..||..|.. ..|...|  ..||.
vdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 137-350 5.4e-65 214.6 In-house 80-292 (298) alignment 
Range on Protein: 137-350
Range on HMM: 80-292/298.0
GTTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDILIrREFTLEN
.   ||||||||...     ..| ||.|| .|..|||.|..|.... |||||  ||  |||. |||||. .|.||.. |.  .. .  |. . |......
adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadliv.rklkvsk

LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH-EKRSG--PIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERPG
 | .|.|.. ....|.|||.|.|  .|  |.... |   ....|  |..|.||||.||||||.||.|.. .        |.  .. . . |  .|..|||
kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlerv.......kkeqvvDvfqvvkvlRkkrpg

MVQTRDQYRFCYLAISEAMNT
.|||..|| |.| |. ||...
avqteeqYvfiyeavlealds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 137-350 4.8e-62 204.9 In-house 72-285 (319) alignment 
Range on Protein: 137-350
Range on HMM: 72-285/319.0
GTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDILIrREFTLEN
|.  |||||||||.    .  .| ||.|| ||| |||.|.||..| |.||||.  |. | |. ||||... |.||..||. ...    |. | |...|..
gvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyii.rklklnk

LKDNK-TRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK---RSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERP
....  ||.. ||||| ||||. | ..|. |...  . . .    |||||||||||.|| |||.... .. .        |.   ... . | ..|  |.
kssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv.......keegvlDvfstvsrlRtqRn

GMVQTRDQYRFCYLAISEAMNT
 |||. .||.|.| |. ||...
imvqrpeqYkfiyealleavea
subfamily_Ptp69D_pd Subfamily Ptp69D 137-349 1.6e-61 203.1 In-house 72-287 (307) alignment 
Range on Protein: 137-349
Range on HMM: 72-287/307.0
GTTLSDYINASFINNG----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDIlIRREFTLEN
|.  |||||||||.      ..|. |.|. .|| |||.||.||....||||. ..|  . ||.||||. || .||. .||. .. . .|  |.||. . .
gkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdy.iiReldvsk

LKD-----NKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV-D-HEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydEKkqapSINLPKLVVEMRN
 |.     ...||.  ..||.|.|   | ...| ||... | . ...  .||||||||| ||||.|||. |.. .  .   |.    .... . | ..|.
kkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlka...ed....kvdifetvkdLrs

ERPGMVQTRDQYRFCYLAISEAMN
.|. .||  .|| |.| |. . ..
qRnllvqsleqYvflyralldyss
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 137-346 6.5e-52 171.8 In-house 85-289 (319) alignment 
Range on Protein: 137-346
Range on HMM: 85-289/319.0
GTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTreeenfKTKCDKYWPDKDEERYGNFIVKFDNNITIPDiLIRREFTLEN
|   ||||||||..    .  || .|||| ||. |||.||||.|.  ||.||      | || .||| | ......| || |      .  . |.. | .
GeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae.yvvrdielse

-LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH----EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhyDEKKQapsINLPKLVVEMRNER
  | .  |||  | .  |||.| | ... ....|  | |    |.   .||||||||.||.|...... .. ..    .|.||   ... ..| ..|..|
dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm....keekq...vdvynfvrdlrqqr

PGMVQTRDQYRFCYLAISE
. .||   || |.| |. |
ntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 137-346 2e-51 170.2 In-house 49-253 (284) alignment 
Range on Protein: 137-346
Range on HMM: 49-253/284.0
GTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTreeenfKTKCDKYWPDKDEERYGNFIVKFDNNITIPDiLIRREFTLEN
|   |||||||||.    .  || ||||| ||. |||.||||.|.  ||.||      | || .||| | ......| || |      .  . |.. | .
GeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee.yvvrdielse

-LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH----EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhyDEKKQapsINLPKLVVEMRNER
  | .. |||  | .  |||.| | ... ....|  | |    |.   .||||||||.||.|...... .. ..    .|.||   ... ..| ..|..|
dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm....keekq...vdvynfvrdlrqqr

PGMVQTRDQYRFCYLAISE
. .||   || |.| |. |
ntlvqdlvqykfiysalle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 137-348 3.3e-41 136.2 In-house 72-279 (439) alignment 
Range on Protein: 137-348
Range on HMM: 72-279/439.0
GTTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKtkcdkYWPDKDEERYGNFIVKFDNNITIPDILIRrEFTLEN
|   | |||| .|.    .  || ||||  .|  |||....|...  |||||   | .|     ||| ..|  ||. .|. | || .|.  ||  | . |
gvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvir.gfkvfn

LKD--NKTRKIYHFQYTTWPDHGTPVSTTGFLKF---VSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNER
 .|  .| | . .|.|..|||.  |  ..  |.|   .   . ..  ||.|||||||.||.|| .|.   . ..       |    ...  .|  .|..|
erdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql.......klenkvdikgivkvlrkqr

PGMVQTRDQYRFCYLAISEAM
  |||.  || | | |. | .
kqmvqalcqyvfiynavledi
0044763 (Phosphotyrosine protein) phosphatases II 137-345 1.2e-39 131.1 In-house 14-168 (178) alignment 
Range on Protein: 137-345
Range on HMM: 14-168/178.0
GTTLSDYINASFINNGTYICTQGPllntiVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEerygnfivkfdnnitipdilirreftlenlkdn
|.  |||||||.| .| |.....|     .|......|.. . ||.|| | |... |||.|||.. .                                 
glersdyinaseilpglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................................

ktrkiYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE--KRSGPIVVHCSAGIGRSGTFVAIHSIVAKfakhydekkqapSINLPKLVVEMRNERPgMVQTR
     ...... .||||.| ..  ||.|| |...   .. ||..||||||.|||||.||.  .               ...|.. . ..|. || .|...
.....iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl............glsleeaielvrerRp.ivpnp

DQYRFCYLAIS
.|.|..|.  .
gqlrqLyefel
0046845 (Phosphotyrosine protein) phosphatases II 138-352 1.2e-74 246.5 In-house 54-278 (284) alignment 
Range on Protein: 138-352
Range on HMM: 54-278/284.0
TTLSDYINASFINNG---------TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD-EERYGNFIVKFDNNITiPDILIRRE
.  |||||||...           ..|.||||| ||. |||.|.||||...|||||...|| ..||..|||...   .||.|.|.. .  .  |  ..|.
ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrt

FTLENLK-DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE----KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHydekKQAPSINLPKLVVE
..|.||. ....|...||.||.|||||.| |.. .|.|. .|..     ...||||||||||.||.|||.|.. .   . |.    ..   ......|  
leltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqleke....glllgvdvleavkr

MRNERPGMVQTRDQYRFCYLAISEAMNTVL
.|. ||||||| .||||.| |. |.....|
lreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRB_pd Subfamily PTPRB 138-350 3.7e-64 211.6 In-house 76-287 (293) alignment 
Range on Protein: 138-350
Range on HMM: 76-287/293.0
TTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK-DEERYGNFIVKFDNNITIPDILIrREFTLEN
.. ||||||..|..      .| ||||| .|. |||.|.||..|.||||||.  |. |.||..|||.. ..  ||.  |.. .. .  |  | ||...|.
esgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvi.relkiek

lkDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK----RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydekkqAPSINLPKLVVEMRNERP
  ....||. ....|.||||| | .|. .|.||  |....    ...|||||||||.||.|||.|.. .. .  .          ...  .|.|.|.|| 
..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.......edyvdifgivaelReeRn

GMVQTRDQYRFCYLAISEAMNT
 .||| .|| | . .. . ...
llvqtekqYifihqcvldllrk
subfamily_PTPN12_pd Subfamily PTPN12 138-357 7.5e-64 210.4 In-house 65-287 (290) alignment 
Range on Protein: 138-357
Range on HMM: 65-287/290.0
TTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEER--YGNFIVKFDNNITIP-DILIRrefTL
.  ||||||.||..     .|| .|||| .|. |||.||||.| .|.||. || |. |.||..|||.. ||.  .|.| |. ... ..  |.|||   ||
eegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflir...tL

ENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVD--HEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydeKKQAPSINLPKLVVEMRNERP
.  .....||.| |.|| |||||.| |..  |.... |   .|. . |.|||||||.|| || .||  .   . .    .| ...... .||.|.|..|.
kveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka....ekipeeldvfdlvlelrkqra

GMVQTRDQYRFCYLAISEAMNTVLKK-EQK
 .|||..||.. | |. | ... |.  |.|
alvqtkeqyelvykavaelvqkeleiieek
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 138-347 1.6e-62 206.2 In-house 72-278 (288) alignment 
Range on Protein: 138-347
Range on HMM: 72-278/288.0
TTLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDE-ERYGNFIVKFDNNITIPDIlIRREFTLEn
.. .||||||.|..     .||.||||| .|. |||....|.... |||||   |. ||||..||||.|. ..||.. |.  .. .  |. . |.. || 
eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledf.vlrkllle.

lKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK--RSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydekkqAPSINLPKLVVEMRNERPGM
 |... ..| ..||..||||| | |.. .|.... |.  .   .|||.||||||.||.|||.|.. .. .  .          |..   | ..|..|. .
.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.......edyiDvagtvaklRkqRall

VQTRDQYRFCYLAISEA
|||  || |.| .. . 
vqtlkqYefiyevllsl
subfamily_PTPRN_pd Subfamily PTPRN 138-353 1.1e-53 176.9 In-house 81-297 (297) alignment 
Range on Protein: 138-353
Range on HMM: 81-297/297.0
TTLSDYINASFIN-----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFD-NNITIPDILIrREFTLE
.. |||||||.|      . .|| ||||| .|. |||.|.||| . .||.||| ||.  ..|..||||. .| |. . |..  . |   | |. | | | 
aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylv.rsfylk

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH--EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEkkqapsINLPKLVVEMRNERPG
||. ..|| .  | . .||..|.| |.  .|.|   |.     || |||||||.| ||.|....|  ......|   |      |..   .  .|..|||
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvke......idiaatlehlrdqrpg

MVQTRDQYRFCYLAISEAMNTVLK
.|.|.||..|.. |..| .|..||
lvktkdqfefaltavaeevnailk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 138-353 1.2e-48 160.5 In-house 45-269 (270) alignment 
Range on Protein: 138-353
Range on HMM: 45-269/270.0
TTLSDYINASFIN-----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE--RYGN-FIVKFDNNITIPDILIRREFT
.  . |||| ...     . .||...||| .|. .||.||||.... |||.|  ||. ..||..||| . .|  .. . .|  .  . .  .  |... .
dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlr

LEnlKDNKTRKIYHFQYTTWPDHGTPVSTT------GFLKFVSFV----DHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhyDEKKqapSINLPKL
||  .. ..|.. ||.|.|||||| | ..         || .  |    .. ....|..||||||.||.||..|.  .|       .|.|   .... ..
le..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlL....eetk...kvdvlai

VVEMRNERPGMVQTRDQYRFCYLAISEAMNTVLK
. |.|..|. .||. .||.| | |..| .....|
ieelRkdRmalvqhpeqyeflykavveyaerrak
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 138-355 1.5e-28 94.6 In-house 54-266 (267) alignment 
Range on Protein: 138-355
Range on HMM: 54-266/267.0
TTLSDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTReeeNFKTKCDKYWPDK--DEERYGNFIVKFDNNITIPDILIrreFTLE
|.  .|||||...    . ..| ||.|| ||| ||...| .|.  .||.||.    |. .  ..|| |  . ..| .. |..  .    |  |    |||
tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqi...itle

-NLKDNKTRKIYHFQYTTWPDHG--TPVStTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKfakhydeKKQAPSINLPKLVVEMRNERP
 ..|.. ....  . |  |       |     ..  ..  . |. . |.||.||.|.||||||. |.| . .        |.    .. ... ..|. |.
lkfknesahnvtlyyykkwnintnnkpyl.kplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqler.......aktegvsdifdflrkirsqri

GMVQTRDQYRFCYLAISEAMNTVLKKE
|.|.|...| ...  ..|  .  ||.|
glvdtkeryiyihellaeyaegrlkee
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 139-348 1.1e-48 160.8 In-house 75-279 (315) alignment 
Range on Protein: 139-348
Range on HMM: 75-279/315.0
TLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKdEERYGNFIVKFDNNITIPDILIRrefTLENLK
  |||.||.||.       ||..|||. ... |||....|..   |||||   |. | |..|||||| .  ||.. |   ..    .. .|   ||    
phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvr...tlsvvf

DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV--DHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydEKkqapSINLPKLVVEMRNERPGMVQ
... |... ..||.||| | | .|. .....  |   |..  |.||||||||.||.|||... ... .      |.     |.. ...  .|. | .|||
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea...en....aidvynfitgvrqnrikmvq

TRDQYRFCYLAISEAM
. .||.| | |. |..
vaeqyqfiydalletf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 139-350 3.3e-47 156.2 In-house 74-293 (325) alignment 
Range on Protein: 139-350
Range on HMM: 74-293/325.0
TLSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTrEEENFKTKCDKYWPDK--DEERYGNFIVKFDNNITIPDIlIRREFTLEN
. |||||||....     ... .| || .|| |.|... . .. ..|.|  | .. | .| .|||..  .  ..| . ||.    .| |  . | . . .
pssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvln.eldlgkdrcavywpkemgksktfGglevklrtieeisdy.vhrvldvkq

LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH--------EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHydekkqaPSINLPKLVVEMR
 |. .|| .  ||. .|.| |..   . .. ..  |..         | |.||.||||||.||.|.|....|..||  ..        .... . |  .|
vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviee.......srvdifgfvkklr

NERPGMVQTRDQYRFCYLAISEAM---NT
..|| ||.| ||| ..| |. ||.   ||
kdrpsmvetvdqyiliyealveaymsgnt
subfamily_PTPN3_pd Subfamily PTPN3 140-348 1.1e-58 193.4 In-house 64-275 (280) alignment 
Range on Protein: 140-348
Range on HMM: 64-275/280.0
LSDYINASFIN---NG-----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDE-ERYGNFIVKFDNNiTIPDILIRREFTL
 .|||||...|   ..      || ||||| .|  |||.|.|||.|..|||||   |. ..|| .|||....  .||.| ||  ..       . ||..|
etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkceke.detksyvlrelvl

ENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK--RSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydEKKQapSINLPKLVVEMRNERP
.. . .. ||| ..||. ||||| | ... ||.||. | . .  .. |.||||||||||.| ....   .|.      |...  ... ...| .||. | 
kdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalali.....eaae..pvypldivrtmrdqra

GMVQTRDQYRFCYLAISEAM
 .||| .||.|   || .. 
mlvqtasqykfvCeailkvy
subfamily_PTPN23_pd Subfamily PTPN23 140-354 2.9e-57 188.7 In-house 66-286 (288) alignment 
Range on Protein: 140-354
Range on HMM: 66-286/288.0
LSDYINASFINNG-----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDE--ERYGNFIVKFDNNITIpDILIRREFTLEN
  |||||||...      ..|.||.|| .|. |||.|..|| |..||||. .|| .|.|.|.||| . .  ...|.. |   .. .  .  ..|...|| 
kDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.ethvervlklet

LKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH------EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEKkqapsiNLPKLVVEMRNE
|. ...... | |.|.||..| | |   .|.|.  |..      .|   |.|||||||.||.|.|  . ..|... |.          .....|  .|..
ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll......diiqvvsrlreq

RPGMVQTRDQYRFCYLAISEAMNTVLKK
|  |||...|..|.| |. || . ||.|
Rrfmvqekeqlkfsyeavleaarrvldk
0051429 (Phosphotyrosine protein) phosphatases II 140-352 2.1e-49 163.9 In-house 3-229 (272) alignment 
Range on Protein: 140-352
Range on HMM: 3-229/272.0
LSDYINASFIN-------NGTYICTQGPLLNTIVDFWKMiWEQNSNIIVMLTREEENFKTKCDKYWP------------DKDEERYGNFIVKFDNNITIP
||.||||....        |......||| .|. |||.. .|.. . ||.|..|||  . |||.|||            .  . .||.. |..   .. .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTtgFLKFVSFVDHekrSGPIVVHCSAGIGRSGTFVAIHSIVAKfakhydekkqapsI------
|...|.      |. ...|...|..|| |||||.| ..  .|...... .   .||..||||||..|.||.||.  ...              .      
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllg.............vsletiv

--------NLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAMNTVL
         | . | |.|  |||.||| .||.|.| |. |.....|
ddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
subfamily_PTPN14_pd Subfamily PTPN14 140-347 7.3e-48 158.1 In-house 75-295 (300) alignment 
Range on Protein: 140-347
Range on HMM: 75-295/300.0
LSDYINASFINN------GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK----DEERYGNFIVKFDNNiTIPDILIRREFT
 ..||||| |.        .|| .|||| .|. |||.|.|||. ..|||||.|||. |.|. ||.|..    .. ..|.| |    . .  | .| . ..
stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs.edsdsvittglk

LENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVD----H-------EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKfakhYDEKKQapsINLPK
|. |  .. |...|.||| ||||| |   .|||...  |.    .       .... |..||||||.||.|  .    ..|     ..  ..   |...|
lkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliat....lehnee...idikk

LVVEMRNERPGMVQTRDQYRFCYLAISEA
 .  .|. |  .|||  ||.| | .. . 
vlarLreqrmllvqtlaqYkfvYkvliky
0046846 (Phosphotyrosine protein) phosphatases II 140-344 2.3e-45 149.8 In-house 11-169 (176) alignment 
Range on Protein: 140-344
Range on HMM: 11-169/176.0
LSDYINASFINNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDkdEERYGNfivkfdnnitipdilirreftlenlkdnktr
 .|||||..|  . .|.||||| .|. ||..|..|.. ...|.|| | |  . ||. |||.  .|..|                                
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi...............................

kiyHFQYTTWPDHGTPVStTGFLKFVSFVDHEKRSG-PIVVHCSAGIGRSGTFVAIHSIVAkfakhydekkqAPSINLPKLVVEMRNERP-GMVQTRDQY
   ..... |||||.| . . .|... |..   ..| |..|||||||||.||.||.  .                ... . . ..|. || |.|||..||
...qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel...........ekglsveealalvreqRplgavqtpeQy

RFCYLAI
||.| ..
rflyefe
0043147 (Phosphotyrosine protein) phosphatases II 140-341 3.8e-45 149.0 In-house 4-154 (172) alignment 
Range on Protein: 140-341
Range on HMM: 4-154/172.0
LSDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREeenfktkcdkywpdkdeerygnfivkfdnnitipdilirreftlENLKD
 |||||||...       .|.||||| ||. |||.|..|.. ..||.||..                                            .....
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpe

NKTRKIYHFQYTTWPDHGTPvSTTGFLKFVSFVDH---EKRSGPIVVHCSAGIGRSGTFVAIHSIVakfakH-YdekkqapsiNLPKLVVEMRNERPGMV
. .| .....|. |||||.| ..  .|.|..|.|.   ....||..||||||.||.||.||.. .      . .         .| . | ..|. |||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.........sleeavalvrekRpgav

QTRDQYRFCY
|. .||||.|
qnpsqyrfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 140-347 1.2e-40 134.1 In-house 34-239 (239) alignment 
Range on Protein: 140-347
Range on HMM: 34-239/239.0
LSDYINASFINN-----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDeERYGNFIVKFDNNITIPDILIRrEFTLENLK
 |||||||.. .      .||.||| .  .  |||.|.|..   .|||||   | .| || .||||    .| |. | . .   . | .||  | . .. 
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skycnlrvtlrktevfadyiir.tfvmsqvg

DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRS--GPIVVHCSAGIGRSGTFVAIHSIVAKfAkhydeKKQApSINLPKLVVEMRNERPGMVQ
. . | .|....| |||.| |  .|  | .   . ..      | |.|||||.||.|.|. | ... . |     |||  .... . |  .|..|| |||
qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq.a.....kkqk.tvdifnyvkairedrphmvq

TRDQYRFCYLAISEA
| .|| | .||. ||
tseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 140-345 3.6e-40 132.6 In-house 35-238 (239) alignment 
Range on Protein: 140-345
Range on HMM: 35-238/239.0
LSDYINASFINN-----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDeERYGNFIVKFDNNITIPDILIRrEFTLENLK
 |||||||.. .      .||.||| .  .  |||.|.|..   .|||||   | .| || .||||    .| |. | . .   . | .||  | . .. 
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skycnlrvtlrktevfadyiir.tfvmsqvg

DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRS--GPIVVHCSAGIGRSGTFVAIHSIVAKfAkhydeKKQApSINLPKLVVEMRNERPGMVQ
. . | .|....| |||.| |  .|  | .   . ..      | |.|||||.||.|.|. | ... . |     |||  .... . |  .|..|| |||
qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq.a.....kkqk.tvdifnyvkairedrphmvq

TRDQYRFCYLAIS
| .|| | .||. 
tseqyvfihlavl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 140-341 2.1e-38 127.1 In-house 66-270 (307) alignment 
Range on Protein: 140-341
Range on HMM: 66-270/307.0
LSDYINASFI----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERygNFIVKFDNNITIPDI---------LIRR
 |||| | ..    .   .||.|||| ||. .|| |. ... . ..|| .  |  | ||..||| .. ..  .  ..  | |.. ..          .  
asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk..lvfgeapntisvanlgakklapdedlin

EFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKrsGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEKkqapsiNLPKLVVEMRNE
  ||.    .|.| | |.|.. |||.|.|    . . ... |  ..   |.|||||||.||||| |||  .  |  .  . |      .. ||| |.|..
vttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt..npvvvhcsaGvGrsGtivaislvqdkmiaGinck......dmkklveelrsq

RPGMVQTRDQYRFCY
|.  .||  || . .
rhyaiqteaqylylh
0051082 (Phosphotyrosine protein) phosphatases II 140-344 7.8e-38 124.8 In-house 2-149 (151) alignment 
Range on Protein: 140-344
Range on HMM: 2-149/151.0
LSDYINASFINNGtYICTQGPlLNtivDFWKMIWEQNSNIIVMLTREEENFktKCDKYWPDKDeerygnfivkfdnnitipdilirreftlenlkdnktR
||||||.|.. .| .....|| |.   ||.....|.. . ||.|. |||.   .| .|.|. .                                    .
lsdyinfsyvtgg.lyrsggp.la...dflellkelgiktivnlrseeerg..ycpeylpelg....................................i

KIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHeKRSGPIVVHCSAGIGRSGTFVAIHSIVAKfakhydekkqapsINLPKLVVEMRNERPGMVQTRDQYRF
...|.... |||.|.|.|.  .|.|...... |..||..||||||.||.||.||.  .  .             ..| . . |.|  |||.||. .|..|
evlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.............vsleealeeyrlkrpgvvqpnqqflf

CYLAI
...|.
qlfal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 140-347 2.2e-37 123.4 In-house 72-235 (392) alignment 
Range on Protein: 140-347
Range on HMM: 72-235/392.0
LSDYINASFI----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFktkcdkywpdkdeerygnfivkfdnnitipdilirreftlenlKD
 |||.|||.|    |. .||..|||   .. |||.|....|   |.|.|. .|                                             | 
dsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................................kg

NKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV--DHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKfAkhydekKQAPSINLPKLVVEMRNERPGMVQT
...| .  |..| |||.. |  |. .|||.  |  |. . . |...|||||.||.|  ..| |.||. |      |..  ... ..|...|..|| ||||
ddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah.a......kktrmvdvfnfvtnirrkrpymvqt

RDQYRFCYLAISEA
..|| | | |. | 
keqyafiygavled
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 140-348 1.3e-14 48.5 In-house 68-279 (303) alignment 
Range on Protein: 140-348
Range on HMM: 68-279/303.0
LSDYINASFINNGT---YICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEerYGNFIVKFDNNITIPDILIRREFTLENLK-D
 | || ||...  .    | || ||  |  |||.|| ||. . ...|  . |  |   |  .| ...  . .|  ..     .  . .   ..|  |   
dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd..flkfeersirvgefkrvelgdgwvlkvlsvs

NKTRK--IYHFQYTTWPDHGTPVS-TTGFLKFV----SFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSivAKFAKHydekKQAPSINLPKLVVEMRNERP
| . |  ..  .| .||    |   .  |.| .    |.. .   | | |    .| ||.|||  . .  |... |    .. .|..| | .  .|| | 
ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet..ahlslh....seqasldlvkclenvrngrl

GMVQTRDQYRFCYLAISEAM
  ||   |. . |  ..| .
havqnlsqfsvvytllaehv
subfamily_PTPN13_pd Subfamily PTPN13 141-351 1.7e-60 199.6 In-house 60-272 (273) alignment 
Range on Protein: 141-351
Range on HMM: 60-272/273.0
SDYINASFIN------NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEER---YGNFIVKFDNNITIpDILIRREFTLE
. |||||.|.      . .|| .|||| .|. |||.|.|||....|.|.| | |. | ||..|||.. ...   .. . |.  .     | .  |.....
ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkl.dgfvvralavk

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKR-SGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYdekkqapSINLPKLVVEMRNERPGM
... ...|.. |.....|||||.| |.. .|.||. | . .. .||||||||||||||||...|. ..   ..         .... ..| ..|. | |.
dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk.......efdvkeivrklreqrqgv

VQTRDQYRFCYLAISEAMNTV
|||.||| |.| || |.....
vqtkdqyifvykailevlksl
subfamily_PTPN1_pd Subfamily PTPN1 141-355 2.7e-60 198.5 In-house 56-278 (290) alignment 
Range on Protein: 141-355
Range on HMM: 56-278/290.0
SDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYG-----NFIVKFDNnITIPDILIRREFTLE
 ||||||...    .  || ||||| ||.  ||.|.|||.|  .||| .  |. ..|| .||| ..||.       .. ||. .   . .  ..| . ||
ndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklis.eerksyytvrllele

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDH----EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhyDEKKQAPSINLPKLVVEMRNER
||| ..||.|.|| |||||| | | | . ||||.  | .     .  || |.||||||||||||. . .....     ..|... |... | ..|.|. |
nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli....ekkddlssvdikkvllelrkyr

PGMVQTRDQYRFCYLAISEAMNTVLKKE
 |..|| || || |||| | .... .. 
lGliqtadqlrfsylaileGakvikgds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 141-350 8.6e-54 177.4 In-house 76-285 (290) alignment 
Range on Protein: 141-350
Range on HMM: 76-285/290.0
SDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPdILIRREFTLENLKD-
 .||||..|.    .  || ||||. ||.|||||.||.... |||||| . |. |.|| .||||.| ..||.| .|  |. |.    |.|.. ..| .  
neyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsa

NKTRKIYHFQYTTWPDHG-TPVSTTGFLKFVSFVDHEKRS--GPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERPGMVQ
...... ..| |.|...|  .  .|  | .   .. ....  ..||||||...|||..|.|..  . |        |.   |.. ... ..|  .||.||
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkc.......ktegvidvfqvlksqRiqkpgsvq

TRDQYRFCYLAISEAMNT
| .||.. .  . .....
tvqqyqgifqivltylds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 141-349 1.5e-52 173.6 In-house 79-285 (297) alignment 
Range on Protein: 141-349
Range on HMM: 79-285/297.0
SDYINASFINNG--TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKtKCDKYWPDKDEERYGNFIVKFDnNITIPDILIRREFTLENLKDNKT
|||.||||..     .|.|| |  .|. |||.|..... ..||||. ..|. | || .||.||    .|.  |.    ..     |.||..... |  ..
sDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvll.svsereGfikrelevtkgkakar

RKIYHFQYTTWPDHGTPV--STTGFLKFVSFVD--HEKRS-GPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERPGMVQT
| .  .|.. |||.  .   |.. .||..| |   ..... ||..|||.||.|| | ...| |.||.        |.  .... .||  .|.||| .|||
rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea.......krekevdifglvkklrqerpylvqt

RDQYRFCYLAISEAMN
..||.| | |. ||. 
keqykfvyvavleall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 141-348 8.2e-52 170.9 In-house 71-276 (515) alignment 
Range on Protein: 141-348
Range on HMM: 71-276/515.0
SDYINASFI----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPD--KDEERYGNFIVKFDNNITIPDILIRrefTLENLK
|||.|||.|    |. .||..|||.  .. |||......|   |.|.|. .|. | || |||||   |  ..|.. |.     .  . ..|   .|. ||
sdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikr...kltvlk

DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV--DHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERPGMVQ
....| .  |..| |||.|.|  |. .||..  |  ||.. . |...|||||.|| | ...|.|.||.        |.. .... ..|  .|..|| .||
gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha.......kttrmvdvfnfvtnirqkrpylvq

TRDQYRFCYLAISEAM
|..|| | | |. | .
tqeqyafiygavledl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 141-349 4.7e-50 165.2 In-house 72-278 (315) alignment 
Range on Protein: 141-349
Range on HMM: 72-278/315.0
SDYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPD--KDEERYGNFIVKFDNNITIPDILIRREfTLenLK
|||||||.|.    . .||..||||  .. |||.|.....   |||.|  .|. | || .||||   |  ..|.. |.  .  .  |  .|.  ..   |
sdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt..rk

DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFV--DHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERPGMVQ
 ...|..  ||.| |||.|..  |. .||..  |  |..|.  ...||||||.||.| ...|...||.        |.. |... ..| ..|..|| .||
seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqi.......krtrsvdvfnfvknlrakrpylvq

TRDQYRFCYLAISEAMN
|...| | | |. | . 
teeeyafiydavledll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 141-350 2.1e-49 163.1 In-house 71-280 (287) alignment 
Range on Protein: 141-350
Range on HMM: 71-280/287.0
SDYINASFINN----GTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNItIPDILIRREFTLENLK-D
 |||||.||.       .| ...|. ||...|||.|...| ..||||..|.|| . .| .|||...   .|.. ... |.  . .  | |.. ..| . .
pdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknka

NKTRKIYHFQYTTWPDHG-TPVSTTGFLKFVSFVDHEKRS--GPIVVHCSAGIGRSGTFVAIHSIVAKFakhydekKQAPSINLPKLVVEMRNERPGMVQ
......  .|.|.|...|  .   | .| .   .  ....  ..||||||...|||..|.|.   . |        |.   |.. ... ..|  .||.||
gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc.......kteGviDvfqvlksqriqkpgsvq

TRDQYRFCYLAISEAMNT
| .||.| . .. | ...
tveqykfindivleylds
0036282 (Phosphotyrosine protein) phosphatases II 141-341 5.9e-43 141.9 In-house 2-163 (174) alignment 
Range on Protein: 141-341
Range on HMM: 2-163/174.0
SDYINASFINN----GTYICTQGPLLntivdFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDkdeerygnfivkfdnnitipdilirreftlenLKDN
|||||||...     . .|..||||      ||.|..|......|||..|.|. ..||  |||.                                |.. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

KTRKIYHFQYTTWPDHGTPVSTTgFLKFVSFVDHE---KRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEKkqapsinlPKLVVEMRNERPGMVQT
 .| .....|. |||||.| ... .|.||.||..    ...||..||||||.||.||.||.  .       ...          .|| |.|. |||||||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvda........ldlvrelRlqrpgmvqt

RDQYRFCY
 .||||.|
psQyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 141-338 2.5e-40 133.0 In-house 81-273 (290) alignment 
Range on Protein: 141-338
Range on HMM: 81-273/290.0
SDYINASFIN--NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE--RYGNFIVKFDNNITIPDILIRREFTLENLKDN
 ||. | ...  . ..| |||.| .|..|.|.|. ...   ||||    |. |.||..|.|.|. |   .|.. |   .. .  . .|.. ... . .. 
GdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsG

KTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVdhEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAkhyDEKKqapsINLPKLVVEMRNERPGMVQTRDQ
|  |..|..  .|||.  . ||  .|. .  .   | |||.||||||||||.||||||   .  .    | |.    ..| .||  .|| | . ||   |
kehklkhlkikswpdksvalstlallrtlril..rkasGpvvvhcsaGiGrtGtfvaievglqill...dGke....ldlldlvralrnsrlnsvqvdiq

YR
| 
yl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 141-349 1.7e-39 130.3 In-house 70-294 (301) alignment 
Range on Protein: 141-349
Range on HMM: 70-294/301.0
SDYINASFINNG----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPD--KDEERYGNFIVKFDNNITIPDILIRREF------
 .|||||.|..      .| .|||. .|.||||..||..    |||.| ..|. |.|| .|||.  ...|..|.| |.. |. ..|| .||.        
reyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdg

--------TLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKR---SGPIVVHCSAGIGRSGTFVAIhSIVAKFAkhydekKQAPSINLP
        ...  .|......  .| | ||..|        |. .  | | ..    ||.|||||....|||..... ||    .      |    ... 
snngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv.siglEQc......kaegVVdvf

KLVVEMRNERPGMVQTRDQYRFCYLAISEAMN
...  .|  .||.|.| .|| . | .|.. ..
qvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_ptpA1_pd Subfamily ptpA1 141-311 6.6e-37 122.2 In-house 75-265 (418) alignment 
Range on Protein: 141-311
Range on HMM: 75-265/418.0
SDYINASFINNG---TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK-----------DEERYGNFIVKFDNNITIPDI-LIR
|||||| .|.      .||||||| ||| |||.|.||.   |||||.|| || . |||.|||..            .| .| . |.. . |  |.  .| 
sdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiit

REFTLEnlKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSF--------VDHEKRSGPIVVHCSAGIGRSGTFVAIHsIVAKFAKHYDEKKQA
|.  |    . .|| | ..||  ||||  |  |  | ...          .    |  ||.||||||.||.|||..   |. |   || .. .|
rnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav.immkkldhyfkqlda
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 141-358 3.6e-35 116.1 In-house 85-296 (305) alignment 
Range on Protein: 141-358
Range on HMM: 85-296/305.0
SDYINASFINNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPD---ILIRREFTLENLK--D
..|. . .| .  .||.|||| .|| .|| |. ... . |||| .  |  | || .|||    |.         .|..           . || ||    
anyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysg

NKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKrsGPIVVHCSAGIGRSGTFVAIHSIVAKFAkhydEKKQAPSinLPKLVVEMRNERPGMVQTRD
...  . |.|.| ||| | |      |...| .   |   ||||||||||||.|| |||  |. | |    |.|..|   .|.||  .|..|   .|.  
dqkmsvrhlqwtewpdrgvppckltslellsairgsk..vpivvhcsagigrtgtivaieyilekia....enkpcpp..mpelvkalrdqrafsiqndv

QYRFCYLAIseaMNTVLKKEQKK
|| | .  .   .| .|.| ..|
qylfihrvm...lnyflekykek
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 141-340 9.3e-31 101.5 In-house 71-261 (281) alignment 
Range on Protein: 141-340
Range on HMM: 71-261/281.0
SDYINASFINNGtYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDE--ERYGNFIVKFDNNiTIPDILIRREFTLEnlKDNKT
..|| . |.. | || ||||  .|  |||.|||..|.  |||| .  |  . || .|.| .     .. .. |....  |.   |.   . |    . .|
anyirspflkrg.yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyeds.tvnkslvttrlnls..yeget

RKIYHFQYTTWPDHGTPVSTTGFLKFVSFVdhEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDekkqAPSINlpKLVVEMR-NERPGMVQTRDQY
| | |. .  |||   | |.  .|| .  .    || | |.|||||.|||||..|.   .     |.      | |.  ..|  .|   |   ||| .||
rlithwlwkewpdwqvpessevmlkilrki..rarstppvihcsagvgrsgtlmaveialqsihshft....lpdik..qivshlrvtgraasvqtlqqy

RFC
 . 
mli
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 141-344 2e-28 94.1 In-house 73-283 (305) alignment 
Range on Protein: 141-344
Range on HMM: 73-283/305.0
SDYINASFI----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDE------ERYGNFIVKFDNNITIP-----D-ILI
 .|| | ..    |   .|||| || .|  ||| | .... . | ||    |    || .|.. ||.      |.    .|||.   |.      .  . 
heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvt

RREFTLENlKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSfvDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHydekKQAPsiNLPKLVVEMR
. ....|    .|.||. |. .  ||| | | . .  |...   .     |||||||||||||.|. | .  |. ..       ..    .  |... .|
etvlvieg.pgekarkvthyhwidwpdrgvpaadlailelle..karpskgpivvhcsagigrtgsvvmleyildqllag....qiie..dtdkilqkir

NERPGMVQTRDQYRFCYLAI
..|   .|| .|| | .  |
eqrnnsiqtdaqylfvhqvi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 141-340 3.1e-24 80.1 In-house 79-282 (310) alignment 
Range on Protein: 141-340
Range on HMM: 79-282/310.0
SD-----YINASFINNgTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD-EERYGNFIVK-FD---NNITIPDILI---RRE
 |     |... .. . |.||.||||  ||.|||.||... .. |..| .  |. . ||  |||     | ||   |  .    ... | .. .     .
edyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdn

FTLENLK-DNKTRKIYHFQYTTWPDHGTPVSTTGFLKfvSFVDHEKRSGPIVVHCSAGIGRSGTFVaihsivaKFAKHYDEKKQAPSINLPKLVVEMRNE
  ...   . |  ..   ..  ||| | |      .     .  . | || |||||||..| .. |       .   ..|  ..   ... ... |....
vpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqvrhgpcvvhcsagkdrlyvvv.......alklkidkldrglkvdaeevktellks

RPGMVQTRDQYRFC
|   .||  || . 
raiciqtelqylii
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 141-350 5.6e-21 69.9 In-house 46-265 (290) alignment 
Range on Protein: 141-350
Range on HMM: 46-265/290.0
SDYINASFIN---NGTYICTQGPLLNT-------IVDFWKMIWEQNSNIIVMLTREEENFKT----KCDKYWPDKDEE--RYGNFIVKFDNNITIPDIlI
.||| |...    .   | || |. ..       | .|| |. . ... .|||   ||. .      | || |.. .|  ..... ||  . ..  |. .
ddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv.e

RREFTLeNLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDheKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDekkqapSINLPKLVVEMR
.|| .. .  |..  .. | ..  | .  .. .|  .|. ...|   ..  |..|||  || || .. ||     |.|.  .      |..| ... ..|
tRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsg......svkledvlkalr

NERPGMVQTRDQYRFCYLAIS----EAMNT
..|  ....  .. |   .|     |....
kqralaitsalelafvdagivllaievldq
subfamily_CG42327_pd Subfamily CG42327 141-260 1.4e-19 64.9 In-house 56-182 (319) alignment 
Range on Protein: 141-260
Range on HMM: 56-182/319.0
SDYINASFIN-----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD----EERYGNFIVKFDNNITiPDILIRREFTLE
. |..||..      .  ||..| .| ..  |||...|||.| .|| ||   |.   .| .|.| |.    .. ||.. | . .. .  |  .   . | 
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev.kdryaistlllk

NLKDNKTRKIYHFQYtTWPDHGTPVSTTG
.......|.. |. |  |.. . | . . 
rvdkeesrelthywy.kwleaevPaeeaa
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 141-258 3e-07 23.5 In-house 55-158 (169) alignment 
Range on Protein: 141-258
Range on HMM: 55-158/169.0
SDYINAsfinngtyictqgpllntivdfwKMIWEQNSNIIVMLTRE--EENFKTKCDKYWPDK---DEERYGNF-IVK---FDNNITIPDILIRREFTLE
||||||                       .|||| |. .||.|      .||  . . |         | | .   |.   .. |..  . |.   . . 
sdyina.......................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvih

NLKDNKTRKIYHFQYTTWPDHGTPVST
. .|. | |.  ..|.|||. | | | 
sydddvteklsllhystwpqngvpqsp
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 141-258 5e-07 22.7 In-house 54-157 (169) alignment 
Range on Protein: 141-258
Range on HMM: 54-157/169.0
SDYINAsfinngtyictqgpllntivdfwKMIWEQNSNIIVMLTRE--EENFKTKCDKYWPDK---DEERYGNF-IV---KFDNNITIPDILIRREFTLE
||||||                       .|||| |. .||.|      .||  . . |         | | .   |   |.. | .  . |.   . ..
sdyina.......................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvih

NLKDNKTRKIYHFQYTTWPDHGTPVST
. .|. |...  ..|.|||. | | | 
sydddvteqlsllhystwpqngvpqsp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 142-347 1.4e-26 88.1 In-house 60-269 (285) alignment 
Range on Protein: 142-347
Range on HMM: 60-269/285.0
DYINASFI-----NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE--RYGNFIVKFDN--NITIPDiLIRREFTLEN
||| ||..     .. ||| ||||| .|. |||.||....   ..||    |    ||  |.|.|  |  ..|.. . . .  . .|    |   .|. |
dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiag.tilnaltvin

LKDNKTRKIY--HFQYTTWPDHGTPVSTTGFLKFVSFVDH-EKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAkhydekkQAPSINLPKLVVEMRNERPG
 .|  .  .|  | |   |||. .|  .  ....  .| . . .  ||.||||||.||. ||| |     .         . | |..  .| |||  |  
tedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirim.......enpniemldivremramrfq

MVQTRDQYRFCYLAISEA
 ||.. |. | |. . | 
avqshmqflflyvvlmey
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 142-360 3.1e-19 63.5 In-house 76-297 (302) alignment 
Range on Protein: 142-360
Range on HMM: 76-297/302.0
DYINASFINN----GTYICTQGPLLNTI---VDFWKMIWEQNSNIIVMLTREEENFKtKCDKYWPDKdEERYGNFIVKFDNNITIPDILIRR-EFTLENL
.|.||| ..      . | .| | ...     .||.|.....   .|.| .|||  |   ....| |  . | ..   | ||  ..     . ....| |
syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk.sgdykeygkmfvNnrkVekaeeektryviEvl

KDNKTR----KIYHFqyTTWPDHGTPVSTTGFLKFVSFV--DHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFakhydEKKQAPSINlpKLVVEMRNER
 .. .     ..|..  | |...  ||. .   | .  |   ..| . ..|.    |.|| |.|..    | |      .|...| |.   .|  .|..|
Pegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavekl.....qkgkepnik..eivksiRsqR

PGMVQTRDQYRFCYLAISEAMNTVLKKEQKKRK
| .|.. .|| . |.|.   . . ..|...|.|
pravdslkQyvslyialllyikkkvtkpeekkk
subfamily_eak_pd Subfamily eak 142-264 2e-16 54.3 In-house 79-203 (332) alignment 
Range on Protein: 142-264
Range on HMM: 79-203/332.0
DYINASFINN---G-TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD--EERYGNFIVKFDNNITiPDILIRREFTLEnlKD
 ||||| ..    |  || |  .  . .  ||.|. ||.|  ||.|  . |.   | |||.|||   | ..| . |.  . .   .||  | . |.  | 
GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvk.rniletrllels..kG

NKTRKIYHFQYTTWPDHGTPVSTtGFLKF
|.| ...|...  | .  .|.    || .
nethrvlhykvfGwtettlpkye.dflal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 142-254 3.7e-10 34.2 In-house 14-126 (130) alignment 
Range on Protein: 142-254
Range on HMM: 14-126/130.0
DYINASFIN----NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENfktkcDKYWPDKDEER-YGNFI-VKFDNNITIPDIlIRREFTLENLKD
.||||||.        |. || || .| .|||||. |.  |..|.|   ||.     |.|||| .    | . | |   .      |    ..  |.   
tyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkni.kasnleiesdln

NKTRKIYHFQYTTWPDHGT
.  . .  || . ||  ||
eshqaltmfqisnwpsdgt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 143-350 6.7e-27 89.0 In-house 69-278 (312) alignment 
Range on Protein: 143-350
Range on HMM: 69-278/312.0
YINASFINNG----TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPD-------KDEERYGNFIVKFDNNITIPDILIRREFTLE
|| | |..       ..|||||| ||.. ||..     |  |..|.   |.   || ||  |       .|   | ..  . .      | .  | . . 
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvv

NLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRsgPIVVHCSAGIGRSGTFVAIHSIVAKFaKHydEKKQapsiNLPKLVVEMRNERPGMV
     .  |. |.|...||||| | |    |...| | ..|.  |.. |||||.||.||.. | |..| . .|   .||    |. .  | .|..|   |
vkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk..pviahcsagvgrtgtlaliesmiaal.rh..prkq....nvkdsfvllrkdrarsv

QTRDQYRFCYLAISEAMNT
..  || ..  .. | . .
rvfpqyvyalrcvleflys
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 143-358 5.3e-26 86.3 In-house 69-279 (288) alignment 
Range on Protein: 143-358
Range on HMM: 69-279/288.0
YINASFINNGTY----ICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD--EERYGNFIVKFDNNITIPDILIRReFTLENLKDN
||.|  .  . |    ||.| ||  ||  .|||. |.. . ||||..  |  | | ..|.| |   . |.| .     .. .  | |..   .| . |  
yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkv.sllriskeg

KTRK-IYHFQYTTWPDHGTPVSTTGFLKFVSFVdhEKRSGPIVVHCSAGIGRSGTFVAIhSIVAKFAKHYDEkkqapsINLPKLVVEMRNERPGMVQTRD
.... . .  .  |.|.| | .   .|...  .  ..   |||||.|||.||.||.. |  |... ..  |       . ...|. ..|.||   .||  
eekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaGvGrtgtlili.lialeslrlddf......lgirsllaklreerfkaiqtem

QYRFCYLAISEAMntVLKKEQKK
|| . .  . | .  .||| ...
qylyvhrcvleel..llkkykvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 150-339 1.4e-34 114.3 In-house 88-272 (301) alignment 
Range on Protein: 150-339
Range on HMM: 88-272/301.0
NNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEER--YGNFIVKFDNN-ITIPDILIRREFTLEN-LKDNKTRKIYHFQ
.   .|.||||| ||  ||| |.   . . ||||... |. ..||..| | | .|.   | | .|  |.   . . ...|.. .|.  .. .|| . |.|
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyq

YTTWPDHGTPVSTTGFLKFVSFVDHEKRsgPIVVHCSAGIGRSGTFVAIHSIVAkfakhydEKKQAPSINLPKLVVEMRNERPGMVQTRDQYRF
|..|.|.|.| | .   ... .| . ..  ||||||||||||| .|.. . .         | .  | |.| . . ..|..|   |||. |  .
ysewtdrgvPkshaelfdlmelvkksek..PivvhcsaGiGrsvafigteylar.......eveadptieltealkhlrehrwngvqtnsqlyw
0049260 (Phosphotyrosine protein) phosphatases II 151-341 2.5e-42 139.5 In-house 8-143 (152) alignment 
Range on Protein: 151-341
Range on HMM: 8-143/152.0
NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWpdkdeerygnfivkfdnnitipdilirreftlenlkdnktrkiyHFQYTTWP
.  .|.||||. ||. |||.|..|.. ..|||||...|. | ||..|.                                            ..... ||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwp

DHGTPVSTTGFLKFVSFVDH--EKRSGPIVVHCSAGIGRSGTFVAIHSIVakfakhydekkqaPSINLPKLVVEMRNERPGMVQTRDQYRFCY
|||.| ..  .| .. |...  ....||..||||||.||.||.||.  .                ..| . |  .|. |||.|.. .|.||.|
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.............lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 151-211 7.6e-07 22.8 In-house 235-293 (440) alignment 
Range on Protein: 151-211
Range on HMM: 235-293/440.0
NGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREeeNFKTkCDKYWPDKD-EERYGNFIV
. ..|.|| ||  |..|||... . .   |.|| .   | || |  ||| .     .| | |
knafiatqmpldstvldfwrlvhdyristiimlnql..ndkt.csiywpvntrsvtfgpftv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 153-341 1.7e-26 87.6 In-house 6-197 (199) alignment 
Range on Protein: 153-341
Range on HMM: 6-197/199.0
TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD--EERYGNFIVKFDNNITIPDILIRREFTLEN-LKDNKTRKIYHFQYTTW
 ||.|| || .|. |||.|.||  |  |||.  .. | ..    |||  .    .||.. |      | ||  |      .|      ||.| |.|.|.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGTPVST--TGFLK---FVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVakfaKHYDEKKqAPSINLPKLVVEMRNERPGMVQTRDQYRFCY
 .. ||  .   ||.     ||    ...  |..|||| | | .| |||.   |    . ..| | .  ..| ..   .|. | |.. . ..| | |
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv....rsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 153-341 1.8e-26 87.6 In-house 5-196 (198) alignment 
Range on Protein: 153-341
Range on HMM: 5-196/198.0
TYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKD--EERYGNFIVKFDNNITIPDILIRREFTLEN-LKDNKTRKIYHFQYTTW
 ||.|| || .|. |||.|.||  |  |||.  .. | ..    |||  .    .||.. |      | ||  |      .|      ||.| |.|.|.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGTPVST--TGFLK---FVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVakfaKHYDEKKqAPSINLPKLVVEMRNERPGMVQTRDQYRFCY
 .. ||  .   ||.     ||    ...  |..|||| | | .| |||.   |    . ..| | .  ..| ..   .|. | |.. . ..| | |
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv....rsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 160-348 4.8e-22 72.8 In-house 99-288 (302) alignment 
Range on Protein: 160-348
Range on HMM: 99-288/302.0
PLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDK--DEERYGNFIVKF-DNNITIPDILIRREFTLENL-------KDNKTRKIYHFQYTTW
|  .|.  .| .| . |  |.| |.   |. . || .|. ||  .| ..|.. ||  . .  . .   ...|.| ..       |... . .  .....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGTPVSTTGFLKFVSFVDHEKRSgpIVVHCSAGIGRSGTFVAIhsivaKFAKHYDEKKQApsINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAM
||||.|  .   |. . | .  |..  ..||||||.||.||.|||     |.  .   ||.    .| ..|. .|. | | ||. .|  .  | .. ..
pdhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvai.....kyGiqlcskkkv..tdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_hpo-7_pd Subfamily hpo-7 161-356 4.5e-26 86.3 In-house 43-236 (263) alignment 
Range on Protein: 161-356
Range on HMM: 43-236/263.0
LLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE--RYGNFIVKFDNNITipDILIRREFTLENLK-DNKTRKIYHFQYTTWPDHGTPVS
|..||  |...|  .... .|||.  .|. . ||..|.| . .|  .. |  |   . .   |.|.. .  |..|.   ||... |..|. |...  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

TTGFLKFVSFVdheKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEKkQAPSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISE-AMNTVLKKEQ
.   |. .  .   . | ..|||||.|||||  |. . ..  |. .  |.  ..  ..  .|. |.|..|.. ..|  |  |  | . .  .|   | | 
areilnilkva...rnskslvvhcstGiGrsaafsvaElvyqkmirsldtt.stveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 164-348 5.8e-27 89.4 In-house 40-221 (255) alignment 
Range on Protein: 164-348
Range on HMM: 40-221/255.0
TIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEE--RYGNFIVKFDNniTIPDILIRREFTLENLK-DNKTRKIYHFQYTTWPDHGTPVSTTG
|.  |...|  .... .|||.  .|. . ||..|.| . .|  .. .  |   .  .. |...|    . .|    ||... |..|. |... .|  .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FLKFVSFVdheKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEKkQAPSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAM
 |. .  |   . | ..|||||.||||| .|| . ..  |. .  |.  ..  ..  .|. |.|..|.. ..|  |  |. | . . .
ilnilkvv...rdsksvvvhCstGiGrsaafvlaelvyqkmirsldtt.etveldylslleelrskrkraihtPlqlafsilmvldlv
PTPlike_phytase Inositol hexakisphosphate 196-298 3.1e-06 21.9 Pfam-A 80-148 (149) alignment 
Range on Protein: 196-298
Range on HMM: 80-148/149.0
KywpdkdeerygnfivkfdnnitipdilirreftleNLKDNKTRKIYHFQYT--TWPDHGTPVStTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVA
.                                   .. .... . ....|   . .|.  |     . .||...   .|.  .|..|.|| ||. |...
e...................................evyeeelaegfgvkYvRipitdeqapee.edvDafvrlikslprdtalvfnCqaGrgRTTtamv

IHSIV
| ...
iadLl
PTPlike_phytase Inositol hexakisphosphate 196-298 3.1e-06 21.9 In-house 80-148 (149) alignment 
Range on Protein: 196-298
Range on HMM: 80-148/149.0
KywpdkdeerygnfivkfdnnitipdilirreftleNLKDNKTRKIYHFQYT--TWPDHGTPVStTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVA
.                                   .. .... . ....|   . .|.  |     . .||...   .|.  .|..|.|| ||. |...
e...................................evyeeelaegfgvkYvRipitdeqapee.edvDafvrlikslprdtalvfnCqaGrgRTTtamv

IHSIV
| ...
iadLl
0048076 (Phosphotyrosine protein) phosphatases II 220-345 6.5e-28 92.6 In-house 26-140 (145) alignment 
Range on Protein: 220-345
Range on HMM: 26-140/145.0
PDILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEK-RSGPIVVHCSAGIGRSGTFVAIHSIVAkfakhydekkqaPSINLPK
 |  |.. ..| . ... .|......|. |||||.| ..  .|.|. |...   . ||..||||||.||.||.||.. .               ...|..
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll............lgvslee

LVVEMRNERPGMVQTRDQYRFCYLAIS
 . ..|. |||.|.. .|.||.|... 
alelvrsqrpgavpnpgqlrflyefel
0048567 (Phosphotyrosine protein) phosphatases II 228-337 8.7e-09 29.9 In-house 17-128 (157) alignment 
Range on Protein: 228-337
Range on HMM: 17-128/157.0
FTLENLKDNKTRKIYHF------QYTT-WPDHGtPVSTTGFLKFVSFVDH-----EKRSGPIVVHCSAGI---GRSGTFVAIHSIVAKFAkhydekkqap
|.|   ..... . ..|      .| . . |.| | . . . .|.  ...     |.....|.|||.||    ||..|... . |               
fallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf..........

siNLPKLVVEMRNERPGMVQTRDQY
  .  . .  .|  |||.|  ||..
..tpeeaiaplrivrpgsvpfrdas
0048179 (Phosphotyrosine protein) phosphatases II 229-342 1.4e-25 85.2 In-house 37-139 (144) alignment 
Range on Protein: 229-342
Range on HMM: 37-139/144.0
TLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE-KRSGPIVVHCSAGIGRSGTFVAIHSIVakfakhydekkqAPSINLPKLVVEMRNER
| |  ..  .| ....... |||||.| ... .|.|. |...  ...||..||||||.||.||.||.. ..               ..| . . ..|. |
teeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk............klglsleealalvrsrr

PGMVQTRDQYRFCYL
||.|....|.||...
pgavpnpgqlrfLle
subfamily_PTPMT1_pd Subfamily PTPMT1 231-297 6.6e-07 23.9 In-house 64-130 (171) alignment 
Range on Protein: 231-297
Range on HMM: 64-130/171.0
ENLKDNKTRKIYHFQYTTWpDHGTPVSTTGFLKFVSFVDHEKRSGPIV-VHCSAGIGRSGTFVAIHSI
.. .. |   . ..|..|. |.   ...   .| | |..... .|  | ||| || |||.| || . .
nsteewkklgveqlqlatv.DfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylm
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 235-343 1.6e-10 34.9 In-house 214-339 (349) alignment 
Range on Protein: 235-343
Range on HMM: 214-339/349.0
DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSF----VD--------HEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDE--KKQAPSIN--LP-
 .|  ... .|.  |.| .. .    .|. .      .|        ..... ...|||||| ||.|..| . .... .    .|  | . ...   |  
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

KLVVEMRNERPGMVQTRDQYRFCYLA
  | |.|  |  |||   |. ..| |
iivnelrkqrismvqnlaqfiaiyea
subfamily_DSP1_pd Subfamily DSP1 235-295 5.2e-06 20.6 In-house 55-116 (163) alignment 
Range on Protein: 235-295
Range on HMM: 55-116/163.0
DNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHE-KRSGPIVVHCSAGIGRSGTFVAIH
||  .......  .  |. .   .. | . . |.|.  |  | . .|| ||| || |.. ..
dnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclay
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 236-348 3.2e-18 60.3 In-house 88-194 (440) alignment 
Range on Protein: 236-348
Range on HMM: 88-194/440.0
NKTRKIYHfqYTTWPDHGTPVSTTGFLKFVSFVDHEK---RSGPIVVHCSAGIGRSGTFVAIHSIVAkfakhydEKKQAPSINLPKLVVEMRNERPGMVQ
..| | ||  |  |||.| |  .   ||..  |.. .    .||..|||||| ||.|  .|. ||.        | |..  |..  ..  |||.|| |||
srtlkqyh..yqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilr.......eakrsdqidifsfinsmrnnrpqmvq

TRDQYRFCYLAISEAM
| .|| | . |. |..
tpeqyafvheavlegl
subfamily_PTPDC1_pd Subfamily PTPDC1 237-340 4.9e-11 37.4 In-house 79-168 (182) alignment 
Range on Protein: 237-340
Range on HMM: 79-168/182.0
KTRKIYHFQYtTWPDHGTPvSTTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIvakFAKHYDEKKqApsinlpklVVEMRNERPGMVQTRDQ
. ..||.... .|.|.|.. | .  |  |  |.   . | . ||| || || |  .| . .   .||... .| |        .  .|..||  .|||.|
meqgiyvynf.gwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliacylv...yakrltaek.a........iklvrskrpksiqtreq

YRFC
 ...
velv
DSPc Dual specificity phosphatase, catalytic domain 238-295 1.9e-07 26.0 Pfam-A 37-94 (133) alignment 
Range on Protein: 238-295
Range on HMM: 37-94/133.0
TRKIYHFQYTtWPD-HGTPVStTGFLKFVSFVDH-EKRSGPIVVHCSAGIGRSGTFVAIH
. .| ....    | . | .|   . . |.|..  |.. . ..||| ||| ||.|... .
kseieylrip.vedetetkis.keleeavefiekaeqkgkkvlVHCqaGisRSatliiaY
DSPc Dual specificity phosphatase, catalytic domain 238-295 1.9e-07 26.0 In-house 37-94 (133) alignment 
Range on Protein: 238-295
Range on HMM: 37-94/133.0
TRKIYHFQYTtWPD-HGTPVStTGFLKFVSFVDH-EKRSGPIVVHCSAGIGRSGTFVAIH
. .| ....    | . | .|   . . |.|..  |.. . ..||| ||| ||.|... .
kseieylrip.vedetetkis.keleeavefiekaeqkgkkvlVHCqaGisRSatliiaY
PTPc_DSPc_SM00012 241-345 2e-32 106.9 In-house 2-104 (105) alignment 
Range on Protein: 241-345
Range on HMM: 2-104/105.0
IYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKR----SGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYdekkqaPSINLPKLVVEMRNERPGMVQTRDQ
..|..||.|||||.| ... .|...  |...|.    |.|.|||||||.||.|||||.  .. .. |.        .... ..| |.|..||||||| .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket......kevdifqivkelrkqRpgmvqteeq

YRFCYLAIS
| |.| |. 
ylflyrall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 241-344 1.3e-16 55.3 In-house 217-340 (350) alignment 
Range on Protein: 241-344
Range on HMM: 217-340/350.0
IYHFQYTTWPDHGTPVSTTGFLKFVS----FVD--------HEKRSGPIVVHCSAGIGRSGTFVAIHSIVA------KFAKHYDEKKQAPSIN--LPKLV
.|..|.  |.| .. .    .|. .     ..|        ...|| ||.||||||.|| ||.|.. |..       .  |.. . ..|  ..  .  .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

VEMRNERPGMVQTRDQYRFCYLAI
 |.|. |  |||. ||. |.| |.
nelrkqrismvqnldqfifiYeal
0038934 (Phosphotyrosine protein) phosphatases II 242-353 1.8e-12 42.8 In-house 70-182 (194) alignment 
Range on Protein: 242-353
Range on HMM: 70-182/194.0
YH----------FQYTTWPDHGTPVSTTGFLKFVSFVDH---EKRSGPIVVHCSAGIGRSGTFVAIHSIVAkfakhYdekkqapSINLPKLVVEMRNERP
|.          .    .||.||. |.   |.|...||.   |. .| ..||| ||.||.||.|| . |       .        ... . .  .|  ||
YdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....l.......gmsaeeAialfrekRp

GMVQTRDQYRFCYLAISEAMNTVLK
|.....|...  .   .| .. || 
gaipnqdyleallkrykelrkavla
PTEN_1 244-293 2.8e-08 28.8 In-house 97-149 (196) alignment 
Range on Protein: 244-293
Range on HMM: 97-149/196.0
FQYTTWPDHGTPVSTTGFLKFVSFVDHEKR---SGPIVVHCSAGIGRSGTFVA
.    ..|||.|     |   .|| .  ..    . ..||| ||.||||| ||
ylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_CDC14_pd Subfamily CDC14 253-336 5.3e-08 27.1 In-house 245-313 (328) alignment 
Range on Protein: 253-336
Range on HMM: 245-313/328.0
GTPvSTTGFLKFVSFVDHEkrSGPIVVHCSAGIGRSGTFVAIHSIvakfaKHYDekkqapsINLPKLVVEMRNERPGMVQTRDQ
.|| | .   ||.. ...   .| |.||| ||.|| ||..| . .     |||        .. .  .  .|  |||.| .  |
stP.sdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiacylm.....khyr.......ftaaeaiawlricrPGsvigpqq
subfamily_DSP23_pd Subfamily DSP23 257-338 1.3e-06 23.1 In-house 66-136 (148) alignment 
Range on Protein: 257-338
Range on HMM: 66-136/148.0
STTGFLKFVSFVDH-EKRSGPIVVHCSAGIGRSGTFVAIHSIvakfaKhydEKKqapsINLPKLVVEMRNERPGMVQTRDQYR
.     .||  |.  |...  . |||  | ||.||..| . .     |   |.|    .   . . |.|. ||| |.| .| .
aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv.....k...erk....laaaeaiaevrrlrpgsvetveqek
PTPc_motif_SM00404 258-296 1.5e-07 26.4 In-house 63-102 (140) alignment 
Range on Protein: 258-296
Range on HMM: 63-102/140.0
TTGFLKFVSFVDH-EKRSGPIVVHCSAGIGRSGTFVAIHS
.  . | ..|..  ||. | ..||| ||. ||.|... . 
skyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 260-344 2.1e-13 44.8 In-house 214-291 (297) alignment 
Range on Protein: 260-344
Range on HMM: 214-291/297.0
GFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKhydekKQAPSINlpKLVVEMRNERPGMVQTRDQYRFCYLAI
 ||.  |.  .  |. ...||||||.||||  |  . |.||  |     |. | ..   ..  .|..|. .||| .|. ..| |.
vflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrk.....kripdva..ailsilreqrarlvqtleqfellydav
subfamily_DSP19_pd Subfamily DSP19 261-300 3.7e-06 21.3 In-house 75-114 (152) alignment 
Range on Protein: 261-300
Range on HMM: 75-114/152.0
FLKFVSFVDHEKRS-GPIVVHCSAGIGRSGTFVaIHSIVAK
. . . |... ... | ..|||.||. || ..| |  ...|
lkealdFieearskdgavlvHCnAGvSRsasvv.iaylmkk
subfamily_CG42327_pd Subfamily CG42327 268-346 2.2e-14 47.9 In-house 241-313 (319) alignment 
Range on Protein: 268-346
Range on HMM: 241-313/319.0
VDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVakfaKHYDEKKQapSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISE
  .... ||.||||| |.||.|. .|    .    .. .| |.  |...|.||  .|..|   |.|..|| | |  .||
sgtresqGPlvvhcsdGvGrtGlviasdiai....rsleeskr..svdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 277-348 3.2e-09 31.1 In-house 1-65 (69) alignment 
Range on Protein: 277-348
Range on HMM: 1-65/69.0
IVVHCSAGIGRSGTFVAIHSivaKFAKHYDEKKqapsINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAM
.|||||.| ||.|||.||     . |.   ||     ...   |  ||  || ||    .| | . |. ||.
mvvhcssgtgrtgtfiaimv...emariksekl....vdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 278-349 2.3e-09 31.5 In-house 1-65 (69) alignment 
Range on Protein: 278-349
Range on HMM: 1-65/69.0
VVHCSAGIGRSGTFVAIHSivaKFAKHYDEKKqapsINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAMN
|||||.| ||.|||.||     . |.   ||     ...   |  ||  || ||   ..| | . |. ||. 
vvhcssGtGrtGtfiaimv...emariksekl....vdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_ptpA1_pd Subfamily ptpA1 314-348 3.2e-06 21.1 In-house 364-398 (418) alignment 
Range on Protein: 314-348
Range on HMM: 364-398/418.0
INLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAM
.||  .|...|..||||||  .|| ||| .| . .
fnlfsivlklreqrpgmvqqleqylfcyktildei