Gene ptpC in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily ptpC
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP048_AA protein Get Run
DdisP048_AA_440-717 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 433-717 2.7e-65 215.6 In-house 19-291 (298) alignment
Range on Protein: 433-717
Range on HMM: 19-291/298.0
EMASKKSHKHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEVPNSyrYYIACQAPLPSTIKDFW
..  ||.   ..  . . .  . . .||.   | .|.|  |||| |... .|.||.|. ..   ..||||| ....   ..   .||.||||..|..|||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFW

RMVWEERSSVIVCLTKLEENGKKKADVYYPETsQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVN
|||.|| ...|| ||.||| .| |   |.|.. ....||.. ..|..|  | |. |  |.. || ||  |||. ||.|.||| |.|  .. . .|   |.
rmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

TfKArgsAKNTNGPVIVHCSAGIGRSGTFISINinmAKIERFGNdpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
. .     .. | ||||.||||.||||||| |.   . .||  .   .  . . . |  ||..| |.||| .||.||.... ..|.
a.sq...qqagnkpvivqCsaGvgRsGtfiaid...svlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 436-721 7.9e-67 220.3 In-house 16-284 (288) alignment
Range on Protein: 436-721
Range on HMM: 16-284/288.0
SKKSHKHHQRHYshNDLDNRKHDEEKFfSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMV
|.....  ...|  | | . ......   . ...|  ||||...|| . .||.|.  |   . |||||.||.||  .. . ||| |.||..|..|||..|
sarnrtgfseey..nsLaalektksvt.agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelv

WEERSSVIVCLTKLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFK
.|...| || ||.| |.||.| . |.|.. . ..|||. . | ..   .|. . .| | ||..|  .|.  ..|. ||| | | |.  .  |  .|.. .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkte..leitqyqylaWpdhgvPeskapllellrqvkvan

ARGsakntNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGI
         ||.|||||||.||.||||...  . ..|.      .  | . . | .||.||  .|||| ||.||..|. ..  . |.
qad.....tgpiivhCsaGvGrtgtFialdalidavee......edyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv

subfamily_Ptp69D_pd Subfamily Ptp69D 436-726 9.1e-58 190.8 In-house 15-300 (307) alignment
Range on Protein: 436-726
Range on HMM: 15-300/307.0
SKKSHKHHQRHYSHNDLDNRKHDEEKFFSALQPNNYgKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMV
|.| . ..     .. | .|. | .  .|. . |.  ||||.|. . ..|||.|..|.   | |||||..|.|   .  . .|| |.|. .||.|||||.
srkrdtdfglakeyekLeareidkstkvsekkenal.knRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmi

WEERSSVIVCLTKLEENGKKKADVYYPETsQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-----PREVVLLHYTQWPDCGAPPSSSHIRTLSVM
.|  . .|| |..|.|  .|| . |.|.  . ..||.  ..| ..   .|    .|.. ||.||       |.||  |||.|.|  .| ..  .  |  .
aeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

VNTFKARGsakntNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT----DMGIRSLS
|.  .        ..|..|||||| ||||.|..... . ...         ...| . | .||.||  .|| |.||.|... . |  .    |. ...|.
vrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlka......edkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle

S
.
d

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 437-717 1.8e-49 163.3 In-house 12-279 (287) alignment
Range on Protein: 437-717
Range on HMM: 12-279/287.0
KKSHKHHQRHYSH--NDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTpieSGDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMV
.| |.. .  ...    |.. ...|..   .. ..|  |||....|. .  || |      . ||||| .|.|   .. . .|....|. .|...||...
akghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgy..kekkafiiaesPmfntarnfWkli

WEERSSVIVCLTKLEENGKKKADVYYPETSQaQEYGSFWIHLHKKVMFKDIGVSSLHLYKKG-EEFPREVVLLHYTQWPDCGAPPSSSHIrtLSVMVNtf
.... ..|| |....|| ...   |.||..    .| . |.| .. . ..  .  |.. .|. .. ...|.  ..|.|.. |  ..   |  | |. .  
ddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti..llviee..

KARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
. .   |..|....||||...|||..|..... . | .. |       | . . . . | |. |.||| .||.||....   |.
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG......viDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 439-717 2.5e-59 195.9 In-house 11-284 (305) alignment
Range on Protein: 439-717
Range on HMM: 11-284/305.0
SHKHHQRHYSHNDL----DNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRM
.. ...| || ..|    ..  ..||...   . .|  |||.... . .  |..||. || |  |||||.|..|   ..   ||. |.||..|..||||.
ayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrl

VWEERSSVIVCLTKLEENGKKKADVYYPETSQA-QEYGSFWIHLHKKVMFKDIGVSSLHLYK-KGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVN
..||. |.|| |||| |.||.|   |.||. .  .|.|.| ..|. .  ..|     |.. . ....  | |. .. |.||| | | ... . .|   |.
iveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq

tfKArgSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
  |.    |. . |..||||||.||.|.||...| . .... .       . . . . .||..| .|||||||| |.. .... .|
..kd..qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEe......vvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

0050432 (Phosphotyrosine protein) phosphatases II 440-717 1.7e-82 272.5 In-house 39-300 (308) alignment
Range on Protein: 440-717
Range on HMM: 39-300/308.0
HKHHQRHYSHNDLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpieSGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERS
.  .. .  ...| . |   .....||.|.|  |||| |.||....||.|    ... |||||.|..| . .. | .||.|.|||.|..||||||||...
ldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

SVIVCLTKLEENGKKKADVYYPET--SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKarg
.|||.||||.|||..| . |.|..  .. .||| |...| .  ...|. |  |.| ..|..  |.|  .||| ||| |.||| ... ..  .|...    
rvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...

saknTNGPVIVHCSAGIGRSGTFISININMAKIERFgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
     .||..||||||.||.|||| . . .  .|.        .... . |  ||.|| |||||..||.|..... . | 
....pggpivVHCsaGvGRtGtfialdllleqleke......ggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0039614 (Phosphotyrosine protein) phosphatases II 440-715 3.3e-75 248.6 In-house 29-288 (297) alignment
Range on Protein: 440-715
Range on HMM: 29-288/297.0
HKHHQRHYSHNDLDNRKHDeekFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES--GDGDYINANYIngEVPNS-YRYYIACQAPLPSTIKDFWRMVWE
 . .. .. . .| . |.|   .  || |.|  |||| |.||....||.|.|...   | |||||.|.  ....   | .||.|.|||.|..||||||||
nsktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedFwrmvwe

ERSSVIVCLTKLEENGKkKADVYYPETSQaqEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKAR
....|||.||||.|.|. | . |.||...  .|| |...| |  . ... |  |.. ..||.  |.|  ..|| ||| |.|||....  .  .|... |.
qgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvrealae

GsakNTNGPVIVHCSAGIGRSGTFISININMAKIERFgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
    . .|||.||||||.||.|||| . . .  .|.        ...... | |||.||.|.|||..||.|..... . 
l...pkggpvlVHCsaGvgRtGtfiaaylmleqleke......ggvdvleavkelreqRpgavqtpsqyrflydallel

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 441-717 6.8e-52 171.3 In-house 15-278 (315) alignment
Range on Protein: 441-717
Range on HMM: 15-278/315.0
KHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPI-ESGDGDYINANYINGeVpNSYRYYIACQAPLPSTIKDFWRMVWEERS
..|   .|..  |    |  .  .| ...|. ||||...|| .|.||.|  | .| | ||||| ||.. | .. . ||| |.||.....||||||..|. 
nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiks.v.dddkayiasqgPlkasvddfwrmvlqekv

SVIVCLTKLEENGKKKADVYYPE-TSQAQEYGSFWIHLHKKVMFKDIGVSSLhLYKKGEEFpREVVLLHYTQWPDCGAPPSSShirTLSVMVNTFKARgs
. || .||..|. | |   |.|.  ... |.||. ..| .     |  .  |   .|.||  | |   ..|.||| |..  .|   .|  ..   ||   
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees.rtvtqfqftewPdkGvdkqts...sllklikevkad..

AKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 .. . ...||||||.||.| .|||.  .|.|.|      .  . . . | .||..|  .||| ..| ||. .. . | 
ngkkefsllvhcsaGvGrtGvvisidevvaqikr......trsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 441-722 4e-50 165.8 In-house 19-298 (325) alignment
Range on Protein: 441-722
Range on HMM: 19-298/325.0
KHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRL-TPIESGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERS
 . |  ..|.       |   .  | .|.|  |||...|.. . .|| | |  .... |||||.|.. ..      ..|.||||..||.|.||.| . |.
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk..dvflaaqaPltatindlWrlvldWrc

SVIVCLTKLEEnGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGS
||.| | .|.. ||..  ||.|.  ......|.. ..|     . |     |.. .  .   | |  ...  |.| | .   . . ..  .|.. . |  
svvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

A-KNTNGPVIVHCSAGIGRSGTFISININMAKIErfgNDpSqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL----TDMGIR
|  .. .|..||||||.||.|.|||.   .||.    .. |  .. | ..|  ||..|  ||.| ||||.|.. . ...    ||. . 
antkastpilvhcsaGvGrtGvfislysalakvi...ee.s..rvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs

0047943 (Phosphotyrosine protein) phosphatases II 444-714 4.4e-77 254.5 In-house 13-270 (273) alignment
Range on Protein: 444-714
Range on HMM: 13-270/273.0
QRHYSHNDLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIV
. .  ...| . |. . ..  || |.|  ||||.|.||....||.|   ..|. |||||.|.  ...|. | .||.|.|||.|..||||||||....|||
llleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

CLTKLEENGKKKADVYYPETSQ--AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAKn
.||.|.|.|..| . |.|.. .   ..|| |...| .   ..|. |  | |...| . .|.|  .||| ||| |.||| ... ..  .|... .    . 
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.

tnGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
  |||.||||||.||.|||| . . .  .|. |      ...... |  ||.|| |||||..||.|. ... .
..gpvvVHCsaGvgRtgtfialdllldqlekeg......gvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 446-718 6.8e-50 164.6 In-house 23-285 (290) alignment
Range on Protein: 446-718
Range on HMM: 23-285/290.0
HYSHNDLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-D--GDYINANYINGEvPNSYrYYIACQAPLPSTIKDFWRMVWEERSSVI
.  .. ||. .. |..   .| ..|  .||........  |. | || .  |   .|||| ||.|   ...  ||| |.|...|..|||...|.|....|
rnqfkmldsges.ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy.kekk.qyiatqgpvsntlvdFWkliwqekvtii

VCLTKLEENGKKKADVYYPETSQAQeYGSFWIHLHKKVMFKDIGVSSLHLYKKGE-EFPREVVLLHYTQWPDCGAPPSSSHIrtlsVMVNTFKARGSAKN
| ||.  |.||.|   |.|...... || | |.|..  .....    |.. .| . . ...|. .. | |.. |  .  . |    ..| .   .   |.
vmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti....llvieemyktqrkr

TNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
.|....||||...|||..|..... . | .  |       | . . . ..| |. |.||| .|| .||...   |. 
gntsivvHCSdtvgrsavfcaaattinkckteg......vidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 446-716 8.2e-40 131.4 In-house 21-237 (392) alignment
Range on Protein: 446-716
Range on HMM: 21-237/392.0
HYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPI-ESGDGDYINANYINGeVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVC
 ....  |    |  .  .| .. |  ||||...|| .|.||.|  | .. | ||.|| ||.. . .. . |||.|.| .....||||||..|. . |. 
lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.f.dnekayiasqgpnaaslddfwrmvfqenvttiam

LTKLEENGkkkadvyypetsqaqeygsfwihlhkkvmfkdigvsslhlykKGEEFpREVVLLHYTQWPDCGAPPSSShirTLSVMVNTFKARGSakNTNG
.|||.|                                            ||..  | |   |.|.||| . |  .|   .|  ...  ||     .   
vtklkegd..........................................kgdda.rtvaqfhftewPdkdvpkhts...sllkfikevkadfG..qyth

PVIVHCSAGIGRSGTFISININMAKIERfgndpSQMnISIKDSVLELRRQRRGMVQTLDQYIFIFKV-INDVL
|.|.|||||.||.|  |||.  .|. ..     ..| . . . | ..||.|  |||| .|| ||.   ..|.|
pliihcsagvgrtgvvisidsvvahakk.....trm.vdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 446-712 2.4e-21 70.5 In-house 29-281 (302) alignment
Range on Protein: 446-712
Range on HMM: 29-281/302.0
HYSHNDLDNRKHDEEKfFSALQpNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYINgeVPNSYRYYIACQAPLPSTI---KDFWRMVWEERSSVI
.  .. .|. | | ||  .| . .|  ||. .||   .|..|.|   |    .|.||  ..  ||.  |  |  | |  ..     .|||||..|.   .
kkefkkidtmkvdlek.Ckafk.knlkknqsedvpildsnlvkl...eaepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VCLTKLEENGKkKADVYYPETS-QAQEYGSFWIHLHKkVMFKDIGVSSLHLYKKGEEFPREVV--LLHYTQWPDCGAPPSSSHIRTLSVMVntFKargSA
| | . ||  |   . ..|..| . .|||....   | |  ..  .. . .    |..   |.  . . |.|..   | . ... .  . |  |.   . 
vilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fa...kk

KNTNGPVIVHCSAGIGRSGTFISININMAKIERFgNDPsqmniSIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 ... ....    |.|| |.|..  . . |...  ..|      ||. |  .| ||  .|..|.||.... ..
ikadentvivSknGaGRagafltlavaveklqkg.kep.....nikeivksiRsqRpravdslkQyvslyial

0043336 (Phosphotyrosine protein) phosphatases II 447-712 9.1e-75 247.0 In-house 24-273 (278) alignment
Range on Protein: 447-712
Range on HMM: 24-273/278.0
YSHNDLDNRKHdeEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCL
  . .|.. |.  . .  || |.|. |||| |.||....||.|.....  | |||||.|.  ...|  | .||.|.|||.|..||||||||.....||.|
lefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

TKLEENGKKKADVYYPetSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGP
|.|.|.|..| . |.|  .. ..|| |...| |   ..|. |  |.. ..|. ..|.|. .||. ||| |.|.| |..  .  .|... .     . |||
telvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.....dsngp

VIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
|.||||||.||.|||| . . .  .|. |      .... . | |||.|| |.|||..||.|.....
vlVHCsaGvgRTGtfialyllleqlekeg......gvdleeavkelreqRpgavqtpsqyrflyeal

0051299 (Phosphotyrosine protein) phosphatases II 448-715 3.7e-80 264.7 In-house 28-285 (288) alignment
Range on Protein: 448-715
Range on HMM: 28-285/288.0
SHNDLDNRKHDeEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGevPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
 ...| . ..|  .. .|| |.|. |||| |.||....||.|..... ...|||||.||.|  .|. | .||.|.|||.|..||||||||....|||.||
efeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmlt

KLEENGKKKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK----GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNT
||.|.|..| . |.|. .. ..|| ....| . ....|. |  |.. ..    |....|.|  .|||.||| |.|.| ... ..  .|... |     ..
klvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.....sg

NGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
.|||.||||||.||.|||| . . .  .|. |       ... . |  ||.|| |||||..||.|..... . 
ggpvvVHCsaGvgRtgtfialdllleqlekeg......gvdvleavkrlreqRpgmvqtpeqyrfvyealley

0040438 (Phosphotyrosine protein) phosphatases II 448-735 1.8e-78 259.3 In-house 23-295 (317) alignment
Range on Protein: 448-735
Range on HMM: 23-295/317.0
SHNDLDNRKHDeeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
 ..||.. |.|   .  |. |.| .|||| |.||....||.|.|...  | |||||.|.  ..||  | .||.|.|||.|. ||||||||....|||.||
efedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

KLEENGKKKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGPV
.|||.|..| . |.|.  . ..|| |...| . .  ..| .  |.....|.. .|.|  .||| ||| |.||| ...  .  .|... .     . .|||
eleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.....dpggpv

IVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGIRSLSSPSKRRSCEM
.||||||.||.|||| . . .  .|. |      ...... | |||.||.|.|||..||.|. ..... |.  . .   |. |..  ..
lVHCsaGvgRtGtfiaaylmleqlekeg......gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl

subfamily_PTPRB_pd Subfamily PTPRB 448-718 1.9e-73 242.1 In-house 30-287 (293) alignment
Range on Protein: 448-718
Range on HMM: 30-287/293.0
SHNDLDNRKHDEeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
 ...| . ..|. .  .| .. |  ||||...|| . .||.|.....  . ||||||||.|   || | .||.| |||.|..||||||||..||.|| ||
eyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy..nsprefiatqGPlpetvddfWrmvwekkssiivmlt

KLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSShirTLSVMVNTFKARGSAKNTNGPV
.| |.||.| . |.|...... ||.  ..| ..   .|  . .|.. |. ||  |.|  .|.| ||| | | ...   ||  .|.|.. . . .....|.
qlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekee..rkvrqyhftsWpdhgvPektk...tlldfvrtvreaiektaskrPi

IVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
.||||||.||.||||...  . .||.      .  . |   | |||..|  .||| .||||| ... |.|..
vvhCsaGvGRtGtfialdrllqaiee......edyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 448-712 9.6e-40 131.3 In-house 9-291 (297) alignment
Range on Protein: 448-712
Range on HMM: 9-291/297.0
SHN--DLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESgDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCL
 ..  ||  ..   |.| || ...   ||||.|.|  ..|||.|    . . |||||.|.     ..  .||  | || .|..|||..|.|.   ||| .
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrvit.erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TKLEENGKKKADVYYPETSQA-QEYGSFWIHLHKK--VMFKDIGVSSLHLYKKgeEFPREVVLLHYTQWPDCGAPPSSSHIRTL--------------SV
.||.|.|..|   |.|.. |  .. |.. .    .    |. . .. |.|. .  .  | |    .  ||| | |     .  .                
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmla

MVNTF--------KARGSAKNTNGPVIVHCSAGIGRSGTFISINInMAKIERFGNDPSQMNIsikdsVLELRRQRRGMVQTLDQYIFIFKVI
.|. |        ..  ...  | ...||||||.||||  .  .. .... | .  |    |     .  || ||  .||||.|. ......
lvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdv.ilaklrkkripdvaai.....lsilreqrarlvqtleqfellydav

subfamily_PTPRD_pd Subfamily PTPRD 449-718 9.1e-80 263.9 In-house 29-283 (564) alignment
Range on Protein: 449-718
Range on HMM: 29-283/564.0
HNDLDNRkhDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEVpnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTK
.......  ..... .| .| |  ||||..... ...||.|...|   . |||||..|.|    . . ||| |.||..||.||||||||..||.|| |||
ykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltk

LEENGKKKADVYYPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGPVI
|||.||.| . |.||..  ..||.. . |.... ..|. . .. | || ..  |||   |.|.||| |.| |  .. .|   |.. .      ...||..
leEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.....pdagPiv

VHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
||||||.||.|||| |.. . .|.       . .. |   | .||.||  |||| .|||||...|.. |. 
VhCSaGVGRTGtfividamlerike......ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

0045450 (Phosphotyrosine protein) phosphatases II 449-714 2.9e-75 249.2 In-house 39-302 (307) alignment
Range on Protein: 449-714
Range on HMM: 39-302/307.0
HNDLDnrkhdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES--GDGDYINANYING------EVPNSYRYYIACQAPLPSTIKDFWRMVWEERSS
 .. .       .. .|| |.|  |||| |.||...|||.|.....  .|.|||||.|..       ..... | .||.|.|||.|..|||||.||....
vtvfl.....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvt

VIVCLTKLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK-GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsa
|||.||.|.|.|..| . |.|.... ..|| |...| ..   ... |  |..  . |....|.|  .||| ||| |.||| ...  .  .|... ..   
vivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel..

kNTNGPVIVHCSAGIGRSGTFISININMAKIERFGNDPSqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
 . .|||.||||||.||.|||| . . .  .|. |  .    ... . | .||.|| |.||...||.|. ... .
.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlld...vdlleavkllreqRpgavqnpeqyrflyealle

subfamily_PTPRN_pd Subfamily PTPRN 449-713 1.5e-46 153.4 In-house 35-289 (297) alignment
Range on Protein: 449-713
Range on HMM: 35-289/297.0
HNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEVPNSyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTK
 . | . . ...    | ...|  |||...||| . .||.|.   |  . |||||  |  . | .   |||.|.||.||. |||.||||. . ||| ||.
wealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra.payiatqgplastvadfwqmvweqGvvvivnltr

LEENGKKKADVYYPETSqAQEYGSFWIHLHK-KVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfKARGsaknTNGPV
|||.| |. . |.|..  .. |. . .||   ..  .|  | |..|     .  | |  .|.  ||. |.|.|.  .  .   ||    ||       |.
leeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk.syrG....rscpi

IVHCSAGIGRSGTFISININMAKIERfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
.||||.| ||.|..| |.. .... .        .| |  ..  || || |.|.| ||. |..... 
vvhcsdGaGrtGvyilidlvlnrllk.....Gvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 450-717 1.2e-63 210.1 In-house 30-284 (319) alignment
Range on Protein: 450-717
Range on HMM: 30-284/319.0
NDLDNRKHDeeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKL
..|.. . |  .| || ...|  ||||...|. . ||| |....   . |||||..|.|   .  . .|| ||||  ||.|||||||||.||..| ||||
kllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlentiedfWrmvWeeessivvmltkl

EENGKKKADVYYPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIrtlSVMVNTFkARGSAKNTNGPVI
 |..| |   |.||.   .||| . . | ..   .|. .. |.| || .|   |||.  .||.||| . | ..  .     ...   ..   |...||..
veklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl...ldllkri.rksrektqsgPiv

VHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
||||||.|| |||| ... . ....      .  . .   | .|| ||  |||. .||.||.... ....
vhCsaGvGRtGtfivldamlervke......egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 450-716 2e-40 133.4 In-house 22-293 (301) alignment
Range on Protein: 450-716
Range on HMM: 22-293/301.0
NDLDNRKhdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES---GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
..|.. .  ...    |. .|   ||.... . .  |. |.| ..      .||||.||.|   .. . .|| |.|. .|..||||..|.|. . || .|
kelkege..dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy..sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

KLEENGKKKADVYYPETSQ-AQEYGSFWIHLHKKVMFKDIGVSSLH---------------LYKKGEEFPREVVLLHYTQWPDCGAPPSSshIRTLSVMV
.|.|. |.|.  |.|....  .|.| | . |... .. |  . .|                . .| .  ...|. |. |.||. |  .       | |. 
nlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep..rtvLqvid

NTFKArgSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.  ..    |   |||.||||....|||...|..| .    .      .  . . . .  .||.. |.|.||.||..|..||.  |
dvihr..qqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka......egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

DSPc_SM00195 451-715 1.1e-78 259.6 In-house 8-261 (263) alignment
Range on Protein: 451-715
Range on HMM: 8-261/263.0
DLDNRKHDEeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
.|.. .... .. .| ...|  |||| ..||...|||.|...|.  . ||||||||.|.  |. . |||.|.|||||..|||||||||....||.||. |
kleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ENGKKKADVYYPETS-QAQEYGSFWIHLHKKVMFK-DIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsakntNGPVI
||||.| | |.||.| . ...|.. ..| ..   | .| .  |.| |.|.| .|.|  ..|..||| |.| | .... |  .|.. | .      .||..
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpiv

VHCSAGIGRSGTFISININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
||||||.||.|||..|.| . |.|.  .      ..|.. | ||| || ||||||.||.|| ..| ..
VhCsaGvgRtgtfvtidiilskleeekk......vdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 451-715 1.1e-78 259.6 In-house 8-261 (263) alignment
Range on Protein: 451-715
Range on HMM: 8-261/263.0
DLDNRKHDEeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
.|.. .... .. .| ...|  |||| ..||...|||.|...|.  . ||||||||.|.  |. . |||.|.|||||..|||||||||....||.||. |
kleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ENGKKKADVYYPETS-QAQEYGSFWIHLHKKVMFK-DIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsakntNGPVI
||||.| | |.||.| . ...|.. ..| ..   | .| .  |.| |.|.| .|.|  ..|..||| |.| | .... |  .|.. | .      .||..
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpiv

VHCSAGIGRSGTFISININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
||||||.||.|||..|.| . |.|.  .      ..|.. | ||| || ||||||.||.|| ..| ..
VhCsaGvgRtgtfvtidiilskleeekk......vdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_PTPN23_pd Subfamily PTPN23 451-712 3.2e-57 188.5 In-house 23-276 (288) alignment
Range on Protein: 451-712
Range on HMM: 23-276/288.0
DLDNRK-HDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTpieSGDGDYINANYINGEVPNSYRyYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
.|.... .. .|.  |.   .  |||..|.|| ...|| |    ..  ||||| .... .| .   .|| ||||.||. |||.||.|..|||||.|.. |
eleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllske

ENGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNT-FKARGSAKNTngPVI
| ||.|.| |.||   .....| . . |...   .      |.|  ....  ..|..|..|.||. |.| | ...  .   |.. ..|.    .|  |..
elgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt..Plv

VHCSAGIGRSGTFISININMAKIerfGNDPSQMniSIKDSVLELRRQRRGMVQTLDQYIFIFKVI
||||||.||.|.|  .   ....    ...  .   | . |  ||.||| |||. .|. | ....
vhCsaGvgRtgvfalvyaavrel...ekgngll..diiqvvsrlreqRrfmvqekeqlkfsyeav

subfamily_PTPN1_pd Subfamily PTPN1 451-712 7.8e-56 183.9 In-house 14-267 (290) alignment
Range on Protein: 451-712
Range on HMM: 14-267/290.0
DLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEE
|...  . . .  .| .|.| ..||| || | . .|..|   |..| |||||. .  |...  | ||  | |||.|.. ||.||||..|  .| | |. |
dirkeas.dfptreaklpenrnlnryrdvspydhsrikl...eradndyinaslv..eleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

NGKKKADVYYPETSQ--AQEY--GSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIrtLSVMvNTFKARGSAKNTNGPV
... |   |.|.  .  . ..   .. ..| .. . .   |. |.| ..  .  ||..  |||.||| | | | .    |. .    .  || ..  ||.
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaf..lkfl.fkvresGslssdvGpa

IVHCSAGIGRSGTFISININMAKIERFGNDpSQmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..||||||||||||. ..  ...||. ..  |   . ||. .||||..| |..|| ||  | .  |
vihcsaGiGrsGtfclvdtclvliekkddl.ss..vdikkvllelrkyrlGliqtadqlrfsylai

subfamily_PTPRG_pd Subfamily PTPRG 452-717 2.9e-62 205.7 In-house 28-288 (563) alignment
Range on Protein: 452-717
Range on HMM: 28-288/563.0
LDNRK-HDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDG--DYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKL
| ..  ... .  .. .|.|  |||| .... ...||.|.|.   ..  ||||||||.|   .  . .|| | ||..|..|||||.||.....|| .|.|
lqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy..qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnl

EENGKKKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLY-----KKGE-EFPREVVLLHYTQWPDCGAPPSsshirTLSVMVNTFKARGSAKNT
.|.|..| |||.|.  ....||.. . | .. ..    | .| .      || . .  ..|   |||.|||.|.| .     .| |. .  |.  . |..
vergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh.....slpvLifvkkssaankae

NGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 ||..||||||.||.||.| ..  . .|..      .  . . . .  .| ||  .||| .||||..... ....
aGPivvHcsaGvgrtGtyivldtllkqiqq......enavnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_PTPN12_pd Subfamily PTPN12 453-717 1.2e-65 216.3 In-house 21-278 (290) alignment
Range on Protein: 453-717
Range on HMM: 21-278/290.0
DNRKHDEE--KFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGevPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
 .. ..|.  .  .. ...|. ||||.|.|| . .|| |. ||. .  ||||||.|.|  ...   ||| |.||| |..|||||.|| . ...| . .. 
sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..vegkleyiaaqgPLpktlddfWrmiweknveivvmaCrev

ENGKKKADVYYPETSQAQE-YGSFWIHLHKKVMFK-DIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGPVI
|.|||| . |.||. . .  .|.| . |... ... |. . .|.. ...|.  |.|  .|||.||| | | | ...  |  .|....      . . |..
elgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkes..rkvyqfhYtaWPDhgvPssaksllelielvrelqe.....sedaPlv

VHCSAGIGRSGTFISININMAKIERfGNDPSqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
||||||.|| || |.|..    ... .. |.  .... | |||||.||  .||| .|| ...| . ....
vhCsaGvGrtGtiiaidyvrellka.ekipe..eldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 453-713 3.9e-57 188.3 In-house 5-261 (270) alignment
Range on Protein: 453-713
Range on HMM: 5-261/270.0
DNRKHDEEKFFSALQPNNYgkNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEVPNsYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEEN
|. ...|... .| . ...  |||.|.||.  ||||| ..|. .   ||||||..|   .  ..||| ..|||.|.|.||||.|||... || .|.|||.
dkeetsesdlpeaargkkl..nRyadiLPsPatRvrleeleedsataYinAnyvrGfdge.kkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

GKKKADVYYPETSQA-QEYGSFWIHLHKKVMFKDIG--VSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSH---IRTLSVMVNTFKARGSAKNTNGP
|.|| ..|.|. ..   ..    |.  .    |. |  .  |.| .||||  |..|  .|..||| |.|... .    . |  |... ..  . .. ..|
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgee..rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

VIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
..||||||.||.||.| ..| .  .|.      .... .   . |||..|  .||. .|| |..|.. 
llvHcsaGvgRtGtlialDiavrlLee......tkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_egg_pd Subfamily egg 453-718 3e-31 103.2 In-house 23-272 (307) alignment
Range on Protein: 453-718
Range on HMM: 23-272/307.0
DNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTpIESG--DGDYINANYINGEvPnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEE
 .   ||. .  |.. ||  | | . |  ..|.||.|  .. |   .|.| ||...|. |  .  .| .||||  | .||||||..|.   || ||   |
leesvdeislttaasdnnlekarskrvhckdssrvkle.lrrGqylddfihanrvkGk.p.llnefilaqaplkntvddfwrmvfqeevqyivmltsrke

NgkKKADVYYPETS-QAQEY--GSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWpdcgappsssHIRTLSVMVNTFKARGSAKNTNGPVI
.  .. . |.| .  ..  .  ||. |.  |     |      .|   | .  .|   | . |.           .. .| .   ..    ..|   ||.
s..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg..........dvnnssdvysplrvlrklrnlskpvv

VHCSAGIGRSGTFISININMAKIERfGndPSqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
|..  |. ...|...|.| . .. | |  |  .   .. .|  ||..||  |..  .|.|.....  .. |
vqdilGvskaatlvaieiallsllr.G..pi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_PTPN3_pd Subfamily PTPN3 454-717 4.1e-64 211.2 In-house 25-276 (280) alignment
Range on Protein: 454-717
Range on HMM: 25-276/280.0
NRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESgdgDYINANYINGEVPNSY--RYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEEN
 ||. . .   | .|.|  ||||.|.|| ..|||.|.  |.   |||||||.| |.| .     |||.| ||..| .|||.||||..||.|| || | |.
yrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

GKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCS
|..|   |.|||.. .|||.| ....|.   | . .  | | .| ..  |... | |..||| | | .|... ..   |.. .     . .. ||.||||
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.....sgkeePvvvhCs

AGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
|||||.| .| ... .|.||.      . .. . | | ..| ||  .||| .|| |. . |  | .
aGigrtGvlilletalaliea......aepvypldivrtmrdqramlvqtasqykfvCeailkvye

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 455-718 5.4e-72 237.5 In-house 31-282 (318) alignment
Range on Protein: 455-718
Range on HMM: 31-282/318.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGK
|....   . .|.| |  |||| ..|. ..|||.|...|.  . ||||||||.|   .. . |||.||||| ||.||||||||  |.||| ||..||.||
rseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy..rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergk

KKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIrtLSvMVNTFKaRGSAKNTNGPVIVHCSAG
.| . |.|. .....||.  ..|...| ..|  . .... ...||  |.|   |||.||| | | |....  |. .| . . .  .|...||..||||||
akvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasl..ld.lvrqvs.kaqqksgagpivvhCsaG

IGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
.|| |.|| ..| . .|.       .  . . . | .||.||  |||| |||.||..|. . |. 
vGrtGvfiavdillerika......ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_PTPN14_pd Subfamily PTPN14 455-716 1.3e-59 196.7 In-house 34-296 (300) alignment
Range on Protein: 455-716
Range on HMM: 34-296/300.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
.|. . .. .|  |.|  |||..|||| | .||.|.| .  . .||||  |.  |  . | ||..|.||. |..|||.||||.  ..|| ||. ||.||.
kkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KADVYYPET---SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSH----IRTLSVMVNTFKARGSAKNTNGPVI
|.  |.|..    .  |.| | .  . .   . .  ..|.|.    .  |.|. | || ||| | |.  ..    .. .  . . ..   ..|... ||.
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
||||||.||.|  |  .. .| .|       . .| || ..  ||.||  .|||| || |..||.   |
vhCsaGvGrtGvlilsdlliatleh......neeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 455-718 1.5e-31 104.2 In-house 33-289 (305) alignment
Range on Protein: 455-718
Range on HMM: 33-289/305.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPieSGDGDYINANYINgeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
|  | ||. .  . .. |||||.||   .  ||.| .  .   .|| |||.    |   . .| .||||  |  ||| | ....   |  | .| | | |
rfndfekmkafkeaqeagknrykdvgcldnnrvkleg..pwpheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgak

KADVYYPETSQA----QEYGS---FWIHLHKKVMFKDI---GVSSLHLYKKGE-EFPREVVLLHYTQWPDCGAPPSSSHIrtLSVMVntfKARgsakNTN
|   |..   .     .| |      .   ... |..     |.   |  .|  |  | |   |. .||| | |..   |  | ..    |||     . 
kcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai..lelle...kar....psk

GPVIVHCSAGIGRSGTFISININMAKIERfGNdpsQmnISIKD-SVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
||..|||||||||.|. . ..  . ..   |.   .  |   |  .  .| ||   .|| .||.|. .|| . . .
gpivvhcsagigrtgsvvmleyildqlla.gq...i..iedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 455-621 1.6e-14 48.2 In-house 81-240 (244) alignment
Range on Protein: 455-621
Range on HMM: 81-240/244.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDgDYINANYInGEVPNSyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENgkk
 . |   .  |..|||  |||    || .  || |.    |.  |||| .. | .  .   ||  | ||  |  |||.|. |    |.| |  .||.   
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgn.tyinasfv.gclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee...

kaDVYYPETSQAQEYG-SFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSS
  | |.|..   . |     . |  .  ||.|  | | .    .|  . . ..  ..||  |. |   
..deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndh

subfamily_PTPN6_pd Subfamily PTPN6 456-714 2.8e-68 225.1 In-house 41-295 (306) alignment
Range on Protein: 456-714
Range on HMM: 41-295/306.0
KHDEEKfFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKK
|.  ..   . .|.|  ||||. .|| . ||| |.  .  . ||||||||..||..| ..||| |  |..|..|||||||.| | ||| .||  | ||.|
kkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkek

ADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLY-KKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAKnTNGPVIVHCSAGI
   |.|.... .|||.  ..  ..   .|  . .|..  || ..  |||. .|...||| | | . ...  .   ||. . . ... ..||..|||||||
CarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea.eagpivvhCsaGi

GRSGTFISININMAKIERFGNDpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
|| |||| |.| . .||. |.|   ..| |...|  .|.|| |.||| .|| |..|.|. 
GRtGtfiviDillkliekkgld...adidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_PTPN9_pd Subfamily PTPN9 456-712 1.1e-57 190.3 In-house 28-286 (297) alignment
Range on Protein: 456-712
Range on HMM: 28-286/297.0
KHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
.  | .|  . .. |  ||||.|||  ..||| |. ..  .  ||||||...|   .  . .|| | ||. |..||||||||..  |||  |...|.|. 
epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy..kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrl

KADVYYP-ETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRT--------LSVMVNTFKARGSAKNTNGP
|   |.| |. ...|.|.. ..  . .. .|  |..|....  .|  |.|.   .. ||| | | |.. .           ...|... ..   . .. |
kcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

VIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..|||||||||.||||...|.....|. |      .. . ..|  || ||  ..|| .|| | .. .
ivvhcsaGiGrtGtfitldiclsrleevg......tvdvvetvkllrtqrafsiqtpeqyefcylav

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-711 1.1e-31 104.5 In-house 39-285 (310) alignment
Range on Protein: 456-711
Range on HMM: 39-285/310.0
KHDEEKFFSALQpNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSyrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKK
| |    . | . ..  |||| ||.  ...||.|.   |  .||| |||.. .   |   .| .| ||  || |||||...||.  |. | |  |.|. |
kqdssltyeayk.kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs..tficsqgplqhtiidfwrmifqeraesilllckvgeegrpk

ADVYYPETSQAQEYGSFWIHLHK----KVMFKDIGVSSLHLYKKGEEFPR-----EVVLLHYTQWPDCGAPPSSSHirtlsvmvnTFKARGSAKNTNGPV
.  |.|    .. ||   .        .    .. |. .      .| |       | |... .|||.| |    |         |   |  |.   ||.
cvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.........tvpqrllaqvrhgpc

IVHCSAGIGRSGTFISININMAKIERfGndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKV
.||||||..| .. ....... |..| |      .. ... . ||...|   .||  ||..| .|
vvhcsagkdrlyvvvalklkidkldr.g.....lkvdaeevktellksraiciqtelqyliidrv

subfamily_CG7180_pd Subfamily CG7180 457-715 7.1e-44 144.6 In-house 29-289 (296) alignment
Range on Protein: 457-715
Range on HMM: 29-289/296.0
HDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKkK
 . ..   .|. .| .|||. .|.| . .|| |. ..   . ||||| |... . .  . ||  .||  .|...|||.|..| .| .| |||  .  | .
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk..keyivteapkketvdefWrlvydeeisavvvLtktfdfak.m

ADVYYPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK---------GEEFP-REVVLLHYTQWPDCGAPPSS-SHIRTLSVMVNTFKARGSAKNTNG
   |.|..|  ..|| . ... ..  . ..    ..|.||         ... . | | |...|.|.     |.| . .  |  .|.... .   ....|
ypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
||.|..| | .||| ...|..|. ..|.      . .. . . |  |||.|...|.. ..| .|. |... 
PvvvvssdGasRsGvylaidanlelvek......eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

0049772 (Phosphotyrosine protein) phosphatases II 457-714 1.2e-43 145.4 In-house 33-278 (314) alignment
Range on Protein: 457-714
Range on HMM: 33-278/314.0
HDEEKFFSALQPNNYGKNRYHDVLPNEsTRVRLTPIESGDGDYINANYINGEvpnsyRYYIACQAPLPSTIKDF----------WRMV--WEERSSVIVC
  |  .  | .. |  ||||.|.|| . .||.|   .  . |||||.|..|      . .||.|.||. |. ||          ||||  .. .. .||.
lpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LTKLEENGkkkadvyypetsqaqeygSF---------WihlhkkvmfkdigvsslHLYKKGEEFPREVVLLHYTQWPDc
                     |..| .||                  ..                             .  .| |.|... .... .|| 
srdevladelsrLdaAlgKtpllildgng..................neptaadlellk.................eelydpelferlgikylripvpD.

GAPPSSSHIRTLSVMVNTFkargsakNTNGPVIVHCSAGIGRSGTFISININMAKIerfgndpsqmNISIKDSVLELRRQRR-----GMVQTLDQYIFIF
| .|...... .  .....       ...|||.|||.||.||.|||. . . | .           ..|... . ..|..|      |....|.||.||.
gsaplledfdeflefieea.......dkggpvlvHCkaGkgRtgtfvvaaylmkll..........gvsleealedvrlkRpinpnpgfieqleqyefil

KVIND
.....
ealle

0036941 (Phosphotyrosine protein) phosphatases II 458-716 3.9e-77 254.8 In-house 27-277 (297) alignment
Range on Protein: 458-716
Range on HMM: 27-277/297.0
DEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKAD
   ..  || |.|  ||||.|.||...|||.|   .... |||||.|.  ....  | .||.|.|||.|. ||||||||....|||.||.|.|.|..| .
llgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

VYYPET-SQAQEYGSFWIHLHKKVM--FKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargSAKNTNGPVIVHCSAGI
 |.|..  . ..|| |...| .     ..|. .  |.....|.. .|.|  .||| ||| |.|.| ...  .  .|...    .. . .|||.||||||.
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl...kllpsggpvlVHCsaGv

GRSGTFISININMAKIERFgndPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
||||||| . . .  .|.      . ...|.. |..||.|| |.||||.||.|.  .. . |
gRsgtfiaadlmlqqledk...lkeggvdileavkklReqRpgavqtleqyrflyeallell

0046845 (Phosphotyrosine protein) phosphatases II 460-716 1.8e-80 265.7 In-house 18-274 (284) alignment
Range on Protein: 460-716
Range on HMM: 18-274/284.0
EKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES--GDGDYINANYINGEVP---NSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
 ..  || |.|. |||| |.||....||.|.....  .|.|||||.|..|      .. . .||.|.|||.|..||||||||....|||.||.|.|||..
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKG-EEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARgsaKNTNGPVIVHCSAG
| . |.|.... ..|| |...| .. ...|. |  | | ..| ....|.|  .|||.||| |.|||.... ..  .|...  .    ...||..||||||
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen...lpgggpivVHCsaG

IGRSGTFISININMAKIERFGNDpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.||.|||| . . .  .|. | .   ..... . |  ||.|| ||||||.||.|..... . |
vgRtGtfialdllleqlekegll...lgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

0045098 (Phosphotyrosine protein) phosphatases II 460-714 2.4e-70 232.4 In-house 23-270 (278) alignment
Range on Protein: 460-714
Range on HMM: 23-270/278.0
EKFFSALQPNNYGKNRYHDVLPNESTRVRltpiesgdgDYINANYINGEvPnsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVY
 ... || ..|. ||||.|.||....||.         |||||.||.|  |   . .||.|.|||||. |||||.||....|||.||.|.|.|..| . |
seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.p...kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

YPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK----GEEFPREVVLLHYTQWPDCGAPPSS--SHIRTLSVMVNTFKA--------RGSAKNTNGP
.|| .. ..|| |...| .  ...|. .  |...       .  .|.|  |||. ||| |.|...  ...  |  ... . .        . .. . .||
wpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VIVHCSAGIGRSGTFISININMAKIerfgndpsQMNISIKDSVLELRRQRRG-MVQTLDQYIFIFKVIND
|.||||||.||.||.. . . .  .        . .... . | |||.||.| .||.|.||.|..... .
vlVHCsaGvgRtGtlvaaylmlell........eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 460-715 3.1e-33 109.9 In-house 23-258 (267) alignment
Range on Protein: 460-715
Range on HMM: 23-258/267.0
EKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGdgdYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKadVY
 .    .  .|  .||. |.|| . ||| |   |     |||| |..|   .  . .|. | ||  || ||. .. ... .||| |||  ..  ..  ..
stisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegy..ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl..fw

YPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGeEFPREVVLLHYTQWPDCGAppSSSHIRTLSVMVntfkARGSAKNTNGPVIVHCSAGIGRSGT
 |.  ||..|  . .    .   .|  . .| |  |  |  ..|.| .| .|          ... |  ..    |.   .| | |..|.||.|.|||||
PPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintn..nkpylkplfgil....aknqlengnrPlvvacsdGvGrsGt

FISINinmAKIERFGNDPsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
|. |.   ...||  ..       | | ....| || |.|.|...||.| ... . 
flvid...sqlerakteg...vsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_PTPRA_pd Subfamily PTPRA 461-720 2.4e-57 189.3 In-house 49-303 (330) alignment
Range on Protein: 461-720
Range on HMM: 49-303/330.0
KFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVY
 .  | . .|  |||. ..||.. .|| |...|   . ||||| .|.|   .   ..||.| |.  |..|||||.|| .|. || ||.|.|  ..|   |
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy..kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

YPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGE----EFPREVVLLHYTQWPDCGAPPSSshIRTLSVMVnTFKArgSAKNTNGPVIVHCSAGIG
.|.   .  ||   ........ .|. |  . . ....    . .| |  .|.| ||| | |  .  |  |...    |.    ... ||..||||||.|
wPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep..iGmlkllk.kvkk..lnqqsagpivvhcsaGvG

RSGTFISININMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV----LTDMG
|.|||| ..  .....      ..  . . . | .|| ||  ||||. || ||.||. .      |.. 
rtGtfivldavlervk......aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 461-712 2.7e-49 163.2 In-house 53-287 (319) alignment
Range on Protein: 461-712
Range on HMM: 53-287/319.0
KFFSALQPnNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTkleengKKKADVY
. |. |.. |  |||. ..|. . ..|.| ...  .  ||||| ...|    .   |||.| ||. |..|||||.|| ..| || ||      |.|   |
qtfanldq.nkdknriinilafdknvvklerliGeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

YPETSQaQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLsvmVNTFKARGSAKNTNGPVIVHCSAGIGRSG
.|   . .... | ....     ..  | ...| ..|.|   |..   |.  ||| | | ..| . .|   |.  .   | .| . ...||||||.||.|
wplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl...vkkvrhltskenhranivvhcsaGvGrtG

TFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..| ... . ....      .  . . . | .||.||  .|| | || ||.  .
vyivldvlldrmke......ekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 461-712 9.9e-48 157.4 In-house 29-273 (287) alignment
Range on Protein: 461-712
Range on HMM: 29-273/287.0
KFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYY
 | .| .  .  |||| |||| . ||| |.       |||||||. .   .    .||.|.|...|..||||.|.|.||.... .|.  |....|.  |.
tfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytdd..eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

PETSQAQEYGSFWIH-LHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMV-NTFKARGSAkNTNGPVIVHCSAGIGRSG
||  .    | . .  | ....  . || .| | .   .  | |  |.. .||| ...|..  .  . . | .  ... .| .  ||..||...||||||
PerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielarda.sevGPlvvhddvGiGrsG

TFISININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..... . . . |  |.      . .   |. || .|...||.  |. .... .
illatlvlvsrledlGr......vdvaavvirlreyraalvqavvqlrllyeal

0037934 (Phosphotyrosine protein) phosphatases II 462-712 1.2e-65 216.8 In-house 2-238 (243) alignment
Range on Protein: 462-712
Range on HMM: 2-238/243.0
FFSALQPNNYGKNRYHDVLPNESTRVRLtpiesGDGDYINANYINGEvPnsyrYYIACQAPLPSTIKD----FWRMVWEERSSVIVCLTKLEENGKKKAD
|. || |.|  |||| |.||.. .||.|     ...||||||.|..  |    ..||.|.|||.|..|    ||||.||....|||.||.|.|.|..| .
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.p....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

VYYPetSQAqEYGSFWIHLHKKVMFKDIGVSSLHLYKKG-EEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKAR---GSAKNTNGPVIVHCSAG
 |.|  ..  .|| |...| .   ..|. |  |.|. .. ....|.|. .||. ||| |.|.| ...  .  .|..|  .     | ...|||.||||||
qywp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

IGRSGTFISININMAKIerfgndpsqmNISIKDSVLELRRQRRG-MVQTLDQYIFIFKVI
.||.||.| . . . ..          .... . | .||.|| | .|||..||.|. ...
vgRtGtliaaylmllll..........gvdleeavkllreqRpgkavqtpsqyrflyeal

subfamily_PTPRK_pd Subfamily PTPRK 462-714 9.3e-55 180.6 In-house 35-275 (314) alignment
Range on Protein: 462-714
Range on HMM: 35-275/314.0
FFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYY
. .| . .|  |||..|.|. . .||.|..|.   . |||||..|..   .  . .|. | ||..|.|||||.|..|... || ||.| |.|. |   |.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsy..krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PETSQAqeYGSFWIHLHKKVMFKDIGVSSLHLYK--KGEEFPREVVLLHYTQWPDCGAPPSSshiRTLSVMVNTFKARGSAknTNGPVIVHCSAGIGRSG
|| ..   || . ..| .  . ... |  . ..|  .| |  |||  .....||| . | |    ..|  .|   |.      ..|...|||||| ||.|
Pedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsa...tgllklvrrvkksqee..eaGrivvhCsaGaGrtG

TFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
||| |.| .  |||      .  . .   | .|| ..  ||.| .||.||. || .
tfiaidivldmier......egvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 462-712 6.2e-49 162.0 In-house 18-251 (284) alignment
Range on Protein: 462-712
Range on HMM: 18-251/284.0
FFSALQPnNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTkleengKKKADVYY
 |. |.. |  |||. ..|. . ..|.| ..   .  ||||| .|.|    .   |||.| ||. |..|||||.|| ..| || ||      |.|   |.
tfanldq.nkdknrighilafdknvvklerliGeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PETSQaQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLsvmVNTFKARGSAKNTNGPVIVHCSAGIGRSGT
|   . .... | ....     ..  | ...| ..|.|   |..   |.  ||| | | ..|.. .|   |.  .   | .| . ...||||||.||.|.
plkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrl...vkkvrhltskenhranivvhcsagvgrtgv

FISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
.| ... . ....      .  . . . | .||.||  .|| | || ||.  .
yivldvlldrmke......ekqvdvynfvrdlrqqrntlvqdlvqykfiysal

0040439 (Phosphotyrosine protein) phosphatases II 463-714 1.4e-68 226.5 In-house 4-244 (249) alignment
Range on Protein: 463-714
Range on HMM: 4-244/249.0
FSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP
  || |.|  ||||.|.||....||.|.....  ..|||||.||  ..... | .||.|.|||.|..|||||.||....|||.||.|.|.|..| . |.|
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsakNTNGPVIVHCSAGIGRSGTFI
. .. .||| |...| .  ...|. |  |.|.....  .|.|  ..|| ||| |.||| ...  .  .|... ..    ...|||.||||||.||.||||
l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtfi

SININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
 . . .  .|. ..      ..... | .||.||.|.||...||.|. ... .
aaylmleqlekelg......vdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 463-545 2.5e-11 37.7 In-house 30-116 (347) alignment
Range on Protein: 463-545
Range on HMM: 30-116/347.0
FSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDG------DYINANYINgeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCL
 |.   ..  ||| .||  ...||| |.| .|  .       |||| .|.    |. . ||  | |||.|..|||.||   . . .| .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashik..fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 464-717 3.6e-61 201.7 In-house 35-277 (281) alignment
Range on Protein: 464-717
Range on HMM: 35-277/281.0
SALQPNNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE
.. ...|  ||||...   . |||..|| | . . ||||||...|   .. . |||.|.|.|.....||.||||.. |.|| .|.  |.|| |   |.|.
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy..kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPd

TSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsAKNTNGPVIVHCSAGIGRSGTFIS
 ... .|| . .. ... . .      ..|.... | .|||. |.||.||| |.| .....      |. ..     |.|. |...|||||.||.||.|.
dnselkygdvtvkstaeeekatyierkfkleresge.treveqlaytaWPdhGvPattkellefrkevlklt....ekktkaplvihCsaGvGrtGtyia

ININMAKIERfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
..  . ..|.     .. ....|. | |||..|  ||||. || |..|.. |.| 
lDrlvkavea.....eleeldvkavvaelrkernlmvqtvvqyefvykavldald

0042113 (Phosphotyrosine protein) phosphatases II 465-713 3e-69 228.4 In-house 4-240 (245) alignment
Range on Protein: 465-713
Range on HMM: 4-240/245.0
ALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPEt
|| |.|  |||| |.||...|||.|.|...  | |||||.|.   ... .. .||.|.|||.|..|||||.||.....||.||..||.|..| . |.|. 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARgsakNTNGPVIVHCSAGIGRSGTFISI
.. ..|| |...| .   ..|. |  |.. ..|. ..|||. .||. ||| |.|......  .  .|... |.    . ||||.||||||.||.|||| .
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsngpvlVHCsaGvgRtGtfiaa

NINMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
 . .  .|. .      ..|. . | |||.||.|.|||..||.|. ... 
ylmleqlekel......gvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_PTPN13_pd Subfamily PTPN13 465-718 7.5e-64 210.6 In-house 32-271 (273) alignment
Range on Protein: 465-718
Range on HMM: 32-271/273.0
ALQPNNYGKNRYHDVLPNESTRVRLTpiesGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS
. . .|  ||||..||| . |||.|     ..| ||||..|. .| .    ||||| ||| |.||||.|||| ...||. .|.  |.|| | . |.||. 
gkkkenkdknryrnvlPydetrvklg....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

QA--QEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsakNTNGPVIVHCSAGIGRSGTFIS
.   . .. . ..| | .  ..  |..|.. ..  .  |||. |....||| | | |. .. ..   |....      . .||..||||||||||||.|.
nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq......tdagPivvhcsaGiGrsGtlit

ININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
|.. .  |||        .. .|. | .||.||.|.||| |||||..|.| .||. 
idvvlglierdk......efdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 466-717 6.1e-60 197.5 In-house 5-243 (250) alignment
Range on Protein: 466-717
Range on HMM: 5-243/250.0
LQPNNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKkADVYYPeTS
 .|.|  |||| |... .|.|| | . .   . ||||| ...|   .  . .|| |.||..||.||||||.|| |..|| ||.|.|..|.    |.| . 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.ve

QAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsaKNTNGPVIVHCSAGIGRSGTFISIN
.|..||.  ..|..| .| |. .  | | |. ..  | |. ||...||| | |     .  |   |.. .     .  |.||||.||||.||||.|| |.
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqq....qagnaPvivqCsaGvgrsGafiaid

inmAKIERFGNdpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
   | .||  .   .  . . . .  ||..| ..|..|.||.|....|   |.
...avlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 467-714 1.7e-50 166.8 In-house 46-277 (315) alignment
Range on Protein: 467-714
Range on HMM: 46-277/315.0
QPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETsq
. .|  ||||..... . .||.|  .|   . ||.|||.|.|   |  | |||.|.|.....|||||.|.||  . || ||.| |. |.||. |.|.   
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGy..nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKgeEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFkargsAKNTNGPVIVHCSAGIGRSGTFISINI
   || . . . .. ..... | .|    .  .  |||| |||| ||| | | ..  .  |   |. .      .|. |...||||||.||.||||... 
kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqh.....htnsvgaivvhcsaGvGrtGtfitlda

NMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
 . ..|       .  | . . .  .|..|..|||...|| ||.... .
vldqae......aenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 467-715 6.3e-33 108.6 In-house 34-268 (281) alignment
Range on Protein: 467-715
Range on HMM: 34-268/281.0
QPNNYGKNRYHDVLPNESTRVRLTP--IESGDGDYINANYINGevPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS
|| |  |||| ..   . .||.|     .    ||| ||||    |   | ||  | |   |  |||||.|.| .. || | .. |  ..|.  |.|  .
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

Q-AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSShirtlsVMVN---TFKARgsakNTngPVIVHCSAGIGRSGTF
. . ..  . .      . | .  . | |  .||   | .    . .|||   | ||       ||..     .||     |  | ..|||||.|||||.
hcclqfdklsvsyedstvnkslvttrlnlsyeget..rlithwlwkewpdwqvpesse......vmlkilrkirar....st..ppvihcsagvgrsgtl

ISININMAKIERFGNDPsqmniSIKDSVLELRRQ-RRGMVQTLDQYIFIFKVINDV
....| .  |      |      ||. |  ||   |   ||||.||..|.||. |.
maveialqsihshftlp.....dikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 467-713 3.8e-30 99.6 In-house 50-286 (305) alignment
Range on Protein: 467-713
Range on HMM: 50-286/305.0
QPN--NYGKNRYHDVLPNESTRVRLTPIEsgDGDYINANYINGEVPNSYRyYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS
| .  .  ||||.||  .. . |.|        ||| |||.   .    | .|..| ||  || .|| || ...   || | |  | || |.  |.| . 
qsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekr.ficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

QAQE-YGSF-WI-H-LHKKVMFKD--IGVSSLHLYKKGEEfPREVVLLHYTQWPDCGAPPSSshIRTLSVMVntfKARGSakntNGPVIVHCSAGIGRSG
  .    |   .      | | .|  | .. |.|   |..    |  |..|.||| | ||    . .| ..      |||    . |..|||||||||.|
geklelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppck..ltslells...airgs....kvpivvhcsagigrtg

TFISININMAKIERFGNDPsqmniSIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
| ..|.  . ||    . |      . . |  || ||   .|.  ||.|| .|. 
tivaieyilekiaenkpcp.....pmpelvkalrdqrafsiqndvqylfihrvml

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 468-712 1.8e-43 143.5 In-house 31-262 (283) alignment
Range on Protein: 468-712
Range on HMM: 31-262/283.0
PNNYGKNRYHDVLPNESTRVRLTPIESgdgDYINANYIN-GEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSqA
 .|  |||.....| .  ||.| .      ||||| .|   .  .  . ||..|.||  |..|||.||..|. . || |||| |. ..|   |.|.   .
denkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.s

QEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfPREVVLLHY--TQWPDCGAPPsssHIRTLsVMVNTFKARgSAKNTNGPVIVHCSAGIGRSGTFISIn
..|| | . |.| .  .   .  | | ...     ...| ||   .| ..|  .    | .| | .|  ..    .. .||..||||.||||...||.. 
edyGeftvtlrkettsnsfiikelllrvnssa.kstlllahyqvidWleygeqa...iinsl.vkfnkvisl.qteskkgPivvhCstgiGrtavfiaa.

inMAKIERFGndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
  .| ..      ..  . .   |  .| || ..||||||| .. ...
..sasvkdal...tesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 469-716 2.7e-49 162.6 In-house 42-276 (515) alignment
Range on Protein: 469-716
Range on HMM: 42-276/515.0
NNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGeVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE-TSQA
 |. ||||...|| .|.||.|  |. . . ||.|| ||.. . .. . ||| |.|......||||.|..|. . |. .|||.|. | |   |.|.  ...
infkknryknilPydsvrvklevindnPhsdyfnasyips.f.dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

QEYGSFWIHLHKKVMFKDIGVSSLHLYKkGEEfPREVVLLHYTQWPDCGAPPSsshIRTLSVMVNTFKArgSAKNTNGPVIVHCSAGIGRSGTFISININ
 ..||. ..|       .     |.. | |..  | |   |.|.||| |.|.     ..|  ..   ||  .  . . |.|.|||||.|| | .|||.  
vkfGsikvelvsleactggikrkltvlk.gdd.srtvtqfhfteWPdkGvpkh...tssllklikevka..dhgqythpliihcsaGvGrtGvvisidsv

MAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.|...          . . . |  .|..|  .||| .|| ||. .. . |
vahakt......trmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 469-717 4.5e-47 155.6 In-house 50-285 (297) alignment
Range on Protein: 469-717
Range on HMM: 50-285/297.0
NNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGevpNSYrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKkKADVYYPETSQAQ
 |. |.||...|| .| ||.|  ...  | ||.|| ...|   | .  .|. | | ..|..|||.||..|. |.|| |....|. | |   |..... ..
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg...nkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt

eYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGApPSSSHIRTLSVMVNTFKARGSAKNTNgPVIVHCSAGIGRSGTFISININM
 .|.  . |.     .     .|.. |      | |   ....|||    .   ....|  ...  .   | .. . |..|||.||.|| | ...|.  .
.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkav.erkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvv

AKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
|...|      . .. | . |  ||..|  .||| .|| |........| 
aeakr......ekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 469-712 3.7e-46 152.3 In-house 2-235 (237) alignment
Range on Protein: 469-712
Range on HMM: 2-235/237.0
NNYGKNRYHDVLPNESTRVRLTPIESGdGDYINANYINGeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQE
.|  |||| ..   . .|| |    ||  |||||.|..| .  . . |||.| || |. .|||.|||.|. |||| || | |. ..|   |.|.| | . 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIrtLSVMVNTFkARGSAKNTNGPVIVHCSAGIGRSGTFISININM
|| . . |.||  | |  | || | |...    | .   ..| ||| | |  .. .  |    |    |    .  || |.|||||.||.| |. |.  .
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaal..lrfrknii.nrsphvsesgpwiihcsagvgrtgiflvidaml

AKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 . .       .  . | . |  .  .|  ..|| |||.||...|
rqak......ekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 469-716 3.4e-39 129.2 In-house 54-283 (290) alignment
Range on Protein: 469-716
Range on HMM: 54-283/290.0
N-NYGKNRYHDVLPNESTRVRLTpiESGDGDYINANYINGEVPnsyrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS-QA
| .. ||||.||  |. ||| |   . .||||. |||..|  .     .|  | .| .|. |.|||| .|. ..|| | .| |.|| | . ||||.. ..
ntefkknrykdvvcndktrvilk..dGydGdyvhanyvkGlka....mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

QEYGSFWIHLHKKvMFKDIGVSSLHLYKKGEEFPREVVLLHY--TQWPDCGAPPSsshirTLSVMVNTFkargSAKNTNGPVIVHCSAGIGRSGTFISIN
  .|.. .   ..   ||  .    |  .  .  .| .| |.    |||   . |     ||...   .    . ....|||.|||||||||.|||..|.
ltfGeitvlcsee.ddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals.....tlallrtlr....ilrkasGpvvvhcsaGiGrtGtfvaie

INMaKIERFGNdpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
. . .|   |      .. . | |  ||. | . ||   ||. . ... |. 
vgl.qilldGk.....eldlldlvralrnsrlnsvqvdiqylalveilldlG

subfamily_ptpA1_pd Subfamily ptpA1 469-673 5.3e-37 122.5 In-house 46-259 (418) alignment
Range on Protein: 469-673
Range on HMM: 46-259/418.0
NNYGKNRYHDVLPNESTRVRLTPIESGDG-DYINANYINGEVPNSyryYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQ
 |  |||| ..|| . |||.|  |.  .| ||||||||.|  |.    .|. | ||| || ||||||||.|  .|| |..  || . |.| |.||    .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq...fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

----------EYGSFWIHLHKKVMF--KDIGVSSLHLYKKGEefPREVVLLHYTQWPDCGAPPSSSHIRTLS-VMVNTFKARGSAKNTNGPVIVHCSAGI
           .|.. . | . .    ..|    ..|  .||   |..   .|  |||   |  .  .| |   . |  .    . . | |.|||||||.
qfsiygngnevfgtysvelveviqdpereiitrnirltfege..trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRSGTFISININMAKIERF
||.||| .  | | |....
grtgtfctavimmkkldhy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 469-713 3.9e-33 109.8 In-house 40-274 (307) alignment
Range on Protein: 469-713
Range on HMM: 40-274/307.0
NNYGKNRYHDVLPNESTRVRLTpIESGDGDYINANYINGEVpnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE-TSQAQ
 |  ||||.||   . .|. .. ..    ||| |||.   .    . .|..| || .|. .|| |. .|.   .. | |. | .| |.. |.|    | .
antdknryqdvkcqdkgrivvk.fdglasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

EYGSFW--I---HLHKKVMFKD---IGVSSLHLYKKGEefPREVVLLHYTQWPDCGAPPSSshirtLsVMVNTFKARgsAKNTNgPVIVHCSAGIGRSGT
 .|.    |    |  | .  |   | |..|..   ..   | .  | ...||| |.|.       |   .| ..|     .|| ||.||||||.|||||
vfgeapntisvanlgakklapdedlinvttlkvdwaqk..srtiqhlqwenwpdrgvpqin.....l.tainlleav..rydtn.pvvvhcsaGvGrsGt

FISININMAKIERfGNDPSQMNisikDSVLELRRQRRGMVQTLDQYIFIFKVIN
 ..| . . |. . | .  .|.    . | ||| ||.  .||  ||... .|. 
ivaislvqdkmia.Ginckdmk....klveelrsqrhyaiqteaqylylhrvll

subfamily_eak_pd Subfamily eak 469-717 2.3e-18 60.7 In-house 51-306 (332) alignment
Range on Protein: 469-717
Range on HMM: 51-306/332.0
NNYGKNrYHDVLPNESTRVRLTPIESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS-QAQ
..  .|   ...|..   ||||.       ||||  .  | ..  | ||   ..  . .  ||.|| |..|  || | .  |.. .| | |.|. . .  
eavnrn.vvkivpydrylvrltssqlnrlGyinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

EYGSFWIHLHKKvMFKDIGVSSLHLYKKGEEFPReVVLLHYTQWPDCGAPPSSSHIRTLSV----------------MVNTFKARGSAKNTNGPVIvHCS
..| . ..  .  . ..|    |   .||.|  | |   ..  | .   |     .    |                .  |.|    .  .. |.|  ..
kfGildverkef.vkrniletrllelskGnethr.vlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsa

AGIGRSGTFISININMAKIErfgnDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 |  |.|.|. |.. .  |.    .  .   |..| .|  . .|   | .  |. ||.... | | 
rGsaraGvfvvidllirlid....nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 469-557 3.9e-09 30.4 In-house 33-119 (332) alignment
Range on Protein: 469-557
Range on HMM: 33-119/332.0
NNYGKNRYHDVLPNESTRVRLTPIEsGDGDYINANYINGEVPNSyrYYIACQAPLPS-TIKDFWRMVWEERSSVIVCLTKLEENGKKKAD
||   ||   .   . .|| |.| . |  |. ||....|   .|   || .|||.   |   ||||| | . |.|. .  ..|. |.|| 
nnmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskks..ayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

Y_phosphatase Protein-tyrosine phosphatase 470-712 2.5e-72 238.4 Pfam-A 1-233 (235) alignment
Range on Protein: 470-712
Range on HMM: 1-233/235.0
NYGKNRYHDVLPNESTRVRLtPIESGDGDYINANYINGEVpNsYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQE
|  ||||.|.|| ..|||.|   ..|. |||||||..|   .  . .||.|.||.|||.|||||||.|...|||.||.|||.|..| . |.| |... ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSFWIHLH-KKV-MFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCSAGIGRSGTFISINI
||.. ..|  |.    |.. .. |.| ||.||  .|||  ||||.||| |.| |....  |  .|.. |     ....|||.||||||.||.|||....|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvaldi

NMAKIERfgN-DpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 . ..|.  . .     ..... | |||.||.||||.|.||||. |.|
lleqlea..eee.....vdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 470-712 2.5e-72 238.4 In-house 1-233 (235) alignment
Range on Protein: 470-712
Range on HMM: 1-233/235.0
NYGKNRYHDVLPNESTRVRLtPIESGDGDYINANYINGEVpNsYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQE
|  ||||.|.|| ..|||.|   ..|. |||||||..|   .  . .||.|.||.|||.|||||||.|...|||.||.|||.|..| . |.| |... ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSFWIHLH-KKV-MFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCSAGIGRSGTFISINI
||.. ..|  |.    |.. .. |.| ||.||  .|||  ||||.||| |.| |....  |  .|.. |     ....|||.||||||.||.|||....|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvaldi

NMAKIERfgN-DpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 . ..|.  . .     ..... | |||.||.||||.|.||||. |.|
lleqlea..eee.....vdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 470-714 3.3e-64 211.6 In-house 28-266 (274) alignment
Range on Protein: 470-714
Range on HMM: 28-266/274.0
NYGKNRYHDVLPNESTRVRLTPIESG--DGDYINANYINGEVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQA-
.  ||||...|||| .|| |.. .|   | .||||||| |   .  . |.| | |||.|..|||||...|...||| ||||.|. ..|  ||.|.. .. 
sqtknryktilPnensrvllesessededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--QEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEefPREVVLLHYTQWPDCGAPPSSSHIrtLSVMVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISIN
  ..|| . |. .|.|  .|  | .| | .  .  .|.|.   ||.|||  .| . ...  |... .. ..| ....  .||.||||||||| | ||.|.
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantl..ldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

INMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
| . ....      .. . .   | .|| .| ||||| .|| .|....  
iavrqlre......eivvdvlkivcnlrldrGGmvqtseqyelihralcl

0041856 (Phosphotyrosine protein) phosphatases II 470-712 2.2e-44 146.6 In-house 1-167 (182) alignment
Range on Protein: 470-712
Range on HMM: 1-167/182.0
NYGKNRYHDVLPNESTRvrltpiesgDGDYINANYINGEVPNSYryYIACQAPLPSTIKDFWRMVWEERSSVIVCLTkleengkkkADVYYPetsqaqey
|. |||| |.||.. .|         | ||||||.. |  |..   .||.|.||.||. ||.||..|.. ..||.||          . |.|        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

gsfwihlhkkvmfkdigvsslhlykkgEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNtfkargsaknTNGPVIVHCSAGIGRSGTFISININMAK
                           |...|... ..|..||| |.|. .. .. .  . .           .|||.||||||.||.||.. . . . .
...........................ellerlgiqylylpwpDhgvpdldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmkkl

ierfgndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
           ..|. . | ..|..| |||.|..||.|.  ..
...........gvsleeavklvrsrRpgmvitpnqyfflqlal

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 470-714 2.5e-43 143.2 In-house 48-277 (439) alignment
Range on Protein: 470-714
Range on HMM: 48-277/439.0
NYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKkkadvYYPETSQaQE
.  ||||.|| . . ||| |  |       |||||||.|   .  . |||.|.|   | .||||.|.|.... || ||.| |  |     |.|  ..   
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd..klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vc

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEE--FPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkarGSAKNTNGPVIVHCSAGIGRSGTFISININ
||   ..  ... . .  .  ...... .     | |. .||. |||   |  .||.  .   .|.       |.  |||.||||||.||.|| |...| 
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrains....andkeeygpvvvhcsagvGrtGtiialdia

MAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
. ..       .. .. ||  |  ||.||. |||.| ||.||.. . .
leqlk......lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 470-711 3.7e-37 122.8 In-house 7-235 (239) alignment
Range on Protein: 470-711
Range on HMM: 7-235/239.0
NYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINgEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSqaQE
|  |||| ...  . .|| |  .      |||||.|.  .   | . ||| |  .  .  |||||.|.||  ||| || | |  |||.  |.|...   .
nkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkargSAKNTNGPVIVHCSAGIGRSGTFISININMA
|  . . |.|  .| |  . .. . . |.   | |   |.| ||| | |  .. .  |   .        .     | ..|||||.||.|.|. |.  . 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.....dslpgarpwvihcsagvgrtgaflvidamlr

KIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKV
. ..      |  . | . |  .| .|  |||| .||.||.  
qakk......qktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 470-710 4.2e-37 122.6 In-house 8-235 (239) alignment
Range on Protein: 470-710
Range on HMM: 8-235/239.0
NYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINgEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSqaQE
|  |||| ...  . .|| |  .      |||||.|.  .   | . ||| |  .  .  |||||.|.||  ||| || | |  |||.  |.|...   .
nkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkargSAKNTNGPVIVHCSAGIGRSGTFISININMA
|  . . |.|  .| |  . .. . . |.   | |   |.| ||| | |  .. .  |   .        .     | ..|||||.||.|.|. |.  . 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.....dslpgarpwvihcsagvgrtgaflvidamlr

KIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFK
. ..      |  . | . |  .| .|  |||| .||.||. 
qakk......qktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 470-716 1.5e-31 104.5 In-house 43-271 (288) alignment
Range on Protein: 470-716
Range on HMM: 43-271/288.0
NYGKNRYHDVLPNESTRVRLTpiesGDGD-YINANYINgevPNSY-RYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQA
|  ..||...   . |||.|.     | | ||.|| .     . | |  | .|||| .||. .|.|. |.    || |..| | ||.|...|.|    ..
nptrdryenlprcditrvkls....ddpdfyiaanvvs...sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

QEYGSFWIHLHKKV--MFKDIGVSSLHLYKKGEEFPrEVVLLHYTQWPDCGAPPS-SSHIRTLSVMvntfkargsaKNTNGPVIVHCSAGIGRSGTFISI
  .| .     ||   . | . || |.  |.|||    |  ||. .|.| | | .  | .| | |.          |... |..||.|||.||.||.| |
arigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl..........kslqkPivvhssaGvGrtgtlili

NINMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
 | .  .       .. ...|.  . .|| .|.  .||  ||....... . |
lialeslr......lddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_CG42327_pd Subfamily CG42327 470-626 2e-29 97.3 In-house 28-186 (319) alignment
Range on Protein: 470-626
Range on HMM: 28-186/319.0
NYGKNRYHDVLPNESTRVRLTPIESGDGD-YINANYINGEvPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS---Q
   |.|. .|.|   ||| |  | . | | |..|.|. |   ..  .|||.|..| ..  ||||.||| .| |||.||.| |.| |.   |.|      .
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGy.ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYtQWPDCGAPPSSSHIRTL
 . || . . | ..   .   .|.| | .  .|  ||.    | .|.... | . . . ..
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 470-719 3.5e-28 93.4 In-house 35-273 (285) alignment
Range on Protein: 470-719
Range on HMM: 35-273/285.0
NYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYINGEVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQAQE
|   ||| ||   | ||| |   .  | ||| |...     .    ||. | ||| |. |||.|...|. . .. |  | | | .|. .||||   .  .
npdlnryadvrcieetrvvl...knhdrdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGSFWIHLHK--KVMFKDIGVSSLHLYKkGEEFPREVVLLHYTQ---WPDCGAPPSSshiRtlsVMVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISI
.| . | | .  .       . .| . .  |.   | . . . |   |||  ||  .   |    |.. .|     .  . |. ||||||.||. ||. |
fgkyeitlteckeeaiagtilnaltvin.tedasseplymnhvqvpwwpdqlapeda...r...pmielykwvkkvnpkekpicvhcsagvgrtatfvgi

NInmAKIERFGNdPsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDM
.   | |  . | |   || . | | |.|  |   ||.  |..|.. |. . .   
dy..atirimen.p...niemldivremramrfqavqshmqflflyvvlmeyfige

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 470-565 1.5e-22 74.8 In-house 47-155 (350) alignment
Range on Protein: 470-565
Range on HMM: 47-155/350.0
NYGKNRYHDVLPNESTRVRLT-PIES--------GDGDYINANYINGEVP---NSYRY-YIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKA
 . ||||...|| | .||.|   ..|           |||||||.. ...       . ||| |||||||..||.... .    ||. ||.. |.. .| 
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

DVYYPETSQ
. |..| | 
yrYWqegsy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 470-565 4.1e-16 53.2 In-house 48-158 (349) alignment
Range on Protein: 470-565
Range on HMM: 48-158/349.0
NYGKNRYHDVLPNESTRVRLTP-------IE-------SG-DGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
 . ||||.|.|| | .||.|         |.       ||   |||||||..    .  . ||| |||||||..||....  ..  ... |.. .|.. .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KADVYYPETSQ
| |.|. | | 
kcdiywqelsy

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 472-706 1.2e-27 91.5 In-house 52-271 (301) alignment
Range on Protein: 472-706
Range on HMM: 52-271/301.0
GKNRYHDVLPNESTRVRLtpIESGDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE-TSQAQEYG
 |.||  |  . || |..  |. |    | ||.|. .     . .|| |.||..| .||| |.       || |..  |. ..| . |.|  .|.  . |
dkhryptvPckPstavev..ivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

SFWIHLH--KKVMFKDIGVSSLHLYKKGEEFP-REVVLLHYTQWPDCGAPpsSSHIRTLSVMvntfkarGSAKNTNGPVIVHCSAGIGRSGTFISININM
 | |...  .... |.|   .|..    ..|. | |.   |..|.| | |   ||. .  .|         .|... |..|||||||||| .||. ..  
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvP..kshaelfdlm.......elvkksekPivvhcsaGiGrsvafigteyla

AKIErfgNDPsqmNISIKDSVLELRRQRRGMVQTLDQYI
 ..|   .||   .| ..... .|| .|   |||  |  
reve...adp...tieltealkhlrehrwngvqtnsqly

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 474-721 1.5e-17 58.3 In-house 47-281 (312) alignment
Range on Protein: 474-721
Range on HMM: 47-281/312.0
NRYHDVLPNESTRVRLTpieSGDGDYINANYINgeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQEYGSFW
||| ..   .  |  |.     .  || ||...  .      ....|.|| .|.  ||...    |. |. |. . |.| .|.  |  .     .     
nrypniqcwdrgrftla...gdenfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

IHLHK------KVMFKD-IGVSSLHLYKKGEefPREVVLLHY--TQWPDCGAPPSSSHIRTLSVMVntfkargsaKNTNGPVIVHCSAGIGRSGTFISIN
..             || |    |..  |     .|  | ||  . ||| | | |      |   |         |. . ||| |||||.||.||.. |.
vyteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsav.........kkdkkpviahcsagvgrtgtlalie

INMAKIErfgnDPSQMNisIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGI
  .| .      | . |  .||| . ||..|   |... ||.. .... ..|   |.
smiaalr....hprkqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

0044763 (Phosphotyrosine protein) phosphatases II 490-711 3e-29 97.3 In-house 10-166 (178) alignment
Range on Protein: 490-711
Range on HMM: 10-166/178.0
TPIES-GDGDYINANYINGEvpnsyrYYIACQAPlpstiKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQaqeygsfwihlhkkvmfkdigvs
...|    .|||||..| .       .|.... |      |......|.  ..||.||.  |.|. | | |.||                          
snleglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................

slhlykkgeefprevVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCSAGIGRSGTFISININMAKierfgndpsqmNISIKDSV
               .  ... .|| |.|....|.. .  .....      .. .|||.||||||.|||||.. . . .             ..|. . .
...............iqylhipipDhgvpdllehflefvefieeal.....dekggpvlVHCsaGvgRsgtlvaaylmkkl...........glsleeai

LELRRQRRgMVQTLDQYIFIFKV
 ..|..|. .|.. .|. .. ..
elvrerRp.ivpnpgqlrqLyef

0046846 (Phosphotyrosine protein) phosphatases II 492-712 1.1e-37 124.8 In-house 7-169 (176) alignment
Range on Protein: 492-712
Range on HMM: 7-169/176.0
IESGDGDYINANYINGEvpnsyrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQEygsfwihlhkkvmfkdigvsslh
.. .| ||||||.| |       ..||.|.|||.|. ||..|..|.. ...|.||.. | |. | . |.||  ...                        
gldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

lykkgeefprevvLLHYTQWPDCGAPPSsSHIRTLSVMVNTFKARGsakntnGPVIVHCSAGIGRSGTFISININMAkierfgndpsQMNISIKDSVLEL
               ... ||| |.|.. ... .|  .....  .|      |||.|||||||||.||.. . . .           ....|. . . ..
.............qylhlpwpDhgvpdl.elllellefirealkeg......gpvlVHCsaGigRtgtlvaayllel..........ekglsveealalv

RRQRR-GMVQTLDQYIFIFKVI
|.||. |.||| .|| |. ...
reqRplgavqtpeQyrflyefe

0043147 (Phosphotyrosine protein) phosphatases II 496-709 5.8e-39 128.9 In-house 4-154 (172) alignment
Range on Protein: 496-709
Range on HMM: 4-154/172.0
DGDYINANYINGEVpnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLeengkkkadvyypetsqaqeygsfwihlhkkvmfkdigvsslhlYKK
. |||||.|... .    . .||.|.||..|. |||||..|.  ..||.||.|                                            .. 
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFkargsAKNTNGPVIVHCSAGIGRSGTFISININMakierfgndpsqMNISIKDSVLELRRQR
.| . |... ..|. ||| |.|...  ...|. . . .     |.. .|||.||||||.||.||.. . . .            ...|. . | ..|..|
pellerlgiqylylpwpDhgvpllellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml............lglsleeavalvrekR

RGMVQTLDQYIFIF
.|.||. .||.|. 
pgavqnpsqyrfly

0051429 (Phosphotyrosine protein) phosphatases II 497-717 8.3e-40 132.5 In-house 4-226 (272) alignment
Range on Protein: 497-717
Range on HMM: 4-226/272.0
GDYINANYINGEvpNS---YRYYIACQAPLPSTIKDFWRMvWEERSSVIVCLTKLEENGKKKADVYYP-----------ETSQAQEYGSFWIHLHKKVMF
..||||....|   ..    ........||| |..||||. .|.. ..||.|...|| |. | | | |           .. .  .|| ... |......
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

KDIGVSSLHLYKK-GEEFPREVVLLHYTQWPDCGAPPSSsHIRTLSVMVNtfkargsakntNGPVIVHCSAGIGRSGTFISININMAKIE--RFGNDPSQ
 |. .  | |... . . .||| .||||.||| |.|...  .. |... .           .|||.||||||..|.||.. . . .. ..     .|   
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

MNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 |. . . | |||.||.|.||| .||.|..... ..| 
tnlyleeaveelraqrpgavqteeqylflyeallellr

0036282 (Phosphotyrosine protein) phosphatases II 497-709 1.2e-36 121.4 In-house 2-163 (174) alignment
Range on Protein: 497-709
Range on HMM: 2-163/174.0
GDYINANYINGEVPNSyrYYIACQAPLPstikdFWRMVWEERSSVIVCLTKLEENGKKKADVYYPEtsqaqeygsfwihlhkkvmfkdigvsslhlykKG
 |||||..... . ..  ..||.|.||.     ||.|..|......|.|....|.|. |   |.||                                . 
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lr

EEFPREVVLLHYTQWPDCGAPPSSShIRTLSVMVNTFKARgsakNTNGPVIVHCSAGIGRSGTFISININMAKIErfgNDPSQMnisiKDSVLELRRQRR
| . |... ..|. ||| |.|..|  ....   |... ..    . .|||.||||||.||.||.. . . .  ..   ... .      | | |||.|| 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvda....ldlvrelRlqrp

GMVQTLDQYIFIF
||||| .||.|. 
gmvqtpsQyrfly

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 497-716 1.3e-18 62.1 In-house 46-259 (290) alignment
Range on Protein: 497-716
Range on HMM: 46-259/290.0
GDYINANYINgeVPNSYRyYIACQAPL-------PSTIKDFWRMVWEERSSVIVCLTKLEENGKKKAD----VYYPETSQ-AQEYGSFWIHLHKKVMFKD
 ||| ||..   .||  |  |. |.|.        |||..|| |. .|..  .| | . ||. ... .     |.||.      .. . ..  .|.  .|
ddyiHAnrvt..cpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

IGVSSLHL-YKKGEEFprEVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakntngPVIVHCSAGIGRSGTFISININMAKIERfgndpSQMNIS
. .  | . . ..|||   |    . .| .. .....  . .|  .|.. |.         ||||||  || || .. .|.. . ||       .. ...
vetRelvvkfddeeef..tvtHsllkgWnklnvqedtktllsliqkvkaskt.........pvivHcvdGiSrsAalaaiilgyQkiae.....tsgsvk

IKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
..| . .||.||  ....  .. |.  .|   .
ledvlkalrkqralaitsalelafvdagivlla

0051082 (Phosphotyrosine protein) phosphatases II 498-711 3.9e-28 93.3 In-house 4-148 (151) alignment
Range on Protein: 498-711
Range on HMM: 4-148/151.0
DYINANYINGEvpnsyryYIACQAPLPstikDFWRMVWEERSSVIVCLTKLEENGkkKADVYYPETSqaqeygsfwihlhkkvmfkdigvsslhlykkge
||||..|. |        ......||.    ||.....|.  ..||.|...||.|  .   |.||..                                 
dyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

efpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkargsakNTNGPVIVHCSAGIGRSGTFISININMAKierfgndpsqmnISIKDSVLELRRQRRG
   .||. .... ||| | | |   .. .  ...         . ||||.||||||.||.||.. . . . .            .|. . . |.|..| |
...ievlhipildwpdpglplsfdavleflellld........kkngpvlvHCsaGkgRTGtlvalylmllg............vsleealeeyrlkrpg

MVQTLDQYIFIFKV
.||. .|..|....
vvqpnqqflfqlfa

0049260 (Phosphotyrosine protein) phosphatases II 513-709 5.4e-36 118.9 In-house 8-143 (152) alignment
Range on Protein: 513-709
Range on HMM: 8-143/152.0
YRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYpetsqaqeygsfwihlhkkvmfkdigvsslhlykkgeefprevvLLHYTQWP
 ...||.|.|.| |..|||||..|   ..||.||.|.|.|| | . |.                                              ....||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwp

DCGAPPSSSHIRTLSVMVNTFkargsAKNTNGPVIVHCSAGIGRSGTFISININMakierfgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIF
| |.|..| ... |  ... .     |.. .|||.||||||.||.||.. . . .            ...|... |  .|..| |.|.. .|..|..
Dhgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylml............lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 513-711 6.8e-21 69.3 In-house 3-198 (198) alignment
Range on Protein: 513-711
Range on HMM: 3-198/198.0
YRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFP--REVVLLHYT
 | |||.| ||  |. |||.||||  |  || .   . | .    .|.| | | . .|||. .  .  .   |  ...| | ..    |  ||.    .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

QWPDCGAPPSSSHIRTLSVMVNTfkARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIF
 | .  .|  .  .  .    .   ..   .. . ||||||| | | .| |....| .   |          . . .    ||. | |.. .|..| ||.
swkekttpnvalfvgfvvasrev..skkyeqekdapvivhcsdgqgftgvfvaldigvrshee....sktsvvdlfevakrlrqarcgiisslqhynfiy

KV
.|
qv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 513-711 7.1e-21 69.3 In-house 4-199 (199) alignment
Range on Protein: 513-711
Range on HMM: 4-199/199.0
YRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFP--REVVLLHYT
 | |||.| ||  |. |||.||||  |  || .   . | .    .|.| | | . .|||. .  .  .   |  ...| | ..    |  ||.    .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

QWPDCGAPPSSSHIRTLSVMVNTfkARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIF
 | .  .|  .  .  .    .   ..   .. . ||||||| | | .| |....| .   |          . . .    ||. | |.. .|..| ||.
swkekttpnvalfvgfvvasrev..skkyeqekdapvivhcsdgqgftgvfvaldigvrshee....sktsvvdlfevakrlrqarcgiisslqhynfiy

KV
.|
qv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 516-595 1.3e-08 28.6 In-house 238-314 (440) alignment
Range on Protein: 516-595
Range on HMM: 238-314/440.0
YIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEEngkKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK
.|| | || ||. ||||.| . | | |. | .|..   |   .|.|  ...  .| | .  .    .. . | .| |  |
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 521-716 2.9e-17 57.1 In-house 98-288 (302) alignment
Range on Protein: 521-716
Range on HMM: 98-288/302.0
APLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS-QAQEYGSFWI---HLHKKV-MFK---DIGVSS--LHLYKKGEEFPREVVLLHYTQ
 |  ||.. .| .. . . ...| |... |...||   || .   .  ..| . .    .....  |    .. . .  .. .|| .. .. | .|... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDCGAPPSSSHIRTLSVMVNTFKargsaKNtngpVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFK
||| |||  . .   .    ...|     ||    |.||||||.||.||...|   .    .      .    . . || .|. | | ||. .| |... 
wpdhGapkeaytaldilkfcesyk.....kn....vlvhcsaGvGrtGtlvaikyGiqlcsk......kkvtdllsivlpvrqcryGavqdeqqliylll

VINDVL
..   |
cvtkgl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 523-715 1.1e-15 52.4 In-house 39-220 (255) alignment
Range on Protein: 523-715
Range on HMM: 39-220/255.0
LpsTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQEYGSFWIHLH---KKVMFKDIGVSSLHLYKKGeefPREVVLLHYTQWPDCGAPP
|  |.. |....   ...|.| |. ..|.|..| . |.| |  . . .    .       .|... . . |    ||     ..|   .|. |..  || 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkk...thtvkhysykGWieknaPe

SSSHIRtlsvmvNTFKArgsAKNTnGPVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
 .  |.      | .|.   ....  .|.||||.||||| .|. ...   |. |  .  .  ..  .  . ||| .|.. ..|  |  | . .. |.
lareil......nilkv...vrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

subfamily_hpo-7_pd Subfamily hpo-7 523-716 6e-13 43.3 In-house 43-227 (263) alignment
Range on Protein: 523-716
Range on HMM: 43-227/263.0
LPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQEYGSFWIHLHKKVMfkDIGVSSLHLYKKGE--EFPREVVLLHYTQWPDCGAPPS
|  ||. |....   ...|.| |.  .|.|..| . |.| |  . | .    .   | .   |. . .|.| .  .     ..|    |. |..  .|  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

SSHIRTLsvmvntFKA-RGSaKntngPVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.  |. .      .|. |.| |    ...||||.|||||  |  ...   |. |  .  |  ..     . ||| .|.. ..|  |  | . .. |..
areilni......lkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

0048076 (Phosphotyrosine protein) phosphatases II 570-712 1e-23 79.0 In-house 14-139 (145) alignment
Range on Protein: 570-712
Range on HMM: 14-139/145.0
GSFWiHLHKKVMFKDIGVSS-LHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARgsakntNGPVIVHCSAGIGRSGTFISININMA
||.. . ..  ..|| |.   | |    | . |... ..|. |||.|.|.........  ..... ..      .|||.||||||.||.||.. . . . 
gslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke......ggpvlVHCsaGvgRtgtlvaaylmll

kierfgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
           ...|. . . ..|.||.|.|.. .|..|.....
...........lgvsleealelvrsqrpgavpnpgqlrflyefe

0038934 (Phosphotyrosine protein) phosphatases II 587-715 5.4e-12 41.2 In-house 63-176 (194) alignment
Range on Protein: 587-715
Range on HMM: 63-176/194.0
VSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsAKNTNGPVIVHCSAGIGRSGTFISINInmakIERfgndpsqMNISIKD
..  . |   |||..  .  .  ..|| |..|| . ...   .|..|     .....| | ||| ||.||.||..   .    |.|       ...| ..
ltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl....nedpggvvaVHCkaGlgRtGtlvaaYL....iyr.......lgmsaee

SVLELRRQRRGMVQTLDQYIFIFKVINDV
..  .|. |.|.... |..  ..|  ...
AialfrekRpgaipnqdyleallkrykel

0048179 (Phosphotyrosine protein) phosphatases II 596-710 2.1e-21 71.6 In-house 42-139 (144) alignment
Range on Protein: 596-710
Range on HMM: 42-139/144.0
GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsaknTNGPVIVHCSAGIGRSGTFISININMakierfgndpsQMNISIKDSVLELRRQR
 |.. ||.. .... ||| |.|.........  ..... .       .|||.||||||.||.||.. . . .            ...|... . ..|..|
pefleregiqylhlpwpDhgvpdllellleflefieeale......eggpvlVHCsaGvgRtgtlvaaylmk...........klglsleealalvrsrr

RGMVQTLDQYIFIFK
 |.|.. .|..|. .
pgavpnpgqlrfLle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 599-711 4.1e-13 43.4 In-house 216-339 (349) alignment
Range on Protein: 599-711
Range on HMM: 216-339/349.0
FPREVVLLHYTQWPDCGAP-PSSSHIRTLSV---MVNTFKARGSAKNTNG-PVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNIS------IKDS
 | |.. | .  |.| .      | ...| |   ....  ||   .. .  ...|||||| ||.|... ... .. .|   |.  ....       |  .
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VLELRRQRRGMVQTLDQYIFIFKV
| |||.||  ||| | |.|.|.. 
vnelrkqrismvqnlaqfiaiyea

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 600-712 5.6e-18 59.8 In-house 214-340 (350) alignment
Range on Protein: 600-712
Range on HMM: 214-340/350.0
PREVVLLHYTQWPDCGA--PPsSSHIRTLS---VMVNTFKARGSAKNTNG-PVIVHCSAGIGRSGTFISININMAKIERFGN---D------PSQMNISI
| .|  |.. .|.| .    |  | ...|     ....  |.   .| .. |..||||||.|| ||.....  . ..| . |   .      .....  |
PyvvyqlqvknWkDlslllnP.esilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

KDSVLELRRQRRGMVQTLDQYIFIFKVI
.  |.|||.||  |||.|||.|||.. .
siivnelrkqrismvqnldqfifiYeal

0048567 (Phosphotyrosine protein) phosphatases II 601-662 1.5e-06 22.7 In-house 35-96 (157) alignment
Range on Protein: 601-662
Range on HMM: 35-96/157.0
REVVLLHYTQWPDCGaPPSSSHIRTLSVMVNTFKarGSAKNTNGPVIVHCSAGI---GRSGTFIS
 .  |.... . | | |.. ...  . ...| |   .. ........|||.||    ||..|.|.
iddglvyedfffdfG.PlnlailyrFilklnkfl..kilelagkaiavhckaglkkrgrtatLig

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 602-714 1.5e-12 41.6 In-house 90-192 (440) alignment
Range on Protein: 602-714
Range on HMM: 90-192/440.0
EVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkarGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndPSQmnISIKDSVLELRRQRRGMVQT
 .   ||  ||| | |  .. .  .   ||        |  |||..|||||| ||.|  |...  . . .|      |  | |   .  .| .|  ||||
tlkqyhyqgwpdkgvpkfagpvlkmiqdvne....sqekagngpllvhcsagagrtgviiavdsilreakr....sdq..idifsfinsmrnnrpqmvqt

LDQYIFIFKVIND
 .|| |..... .
peqyafvheavle

PTPc_DSPc_SM00012 603-713 4.5e-30 99.3 In-house 2-104 (105) alignment
Range on Protein: 603-713
Range on HMM: 2-104/105.0
VVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAkntNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqMNISIKDSVLELRRQRRGMVQTL
|  .|||.|||.|.| .|..| .|   |...|   .    ..||.||||||.||.|||. . | . ..|.        ...|.. | |||.||.|||||.
vkhyhytgwpdhgvPeesdsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqqleket.....kevdifqivkelrkqRpgmvqte

DQYIFIFKVIN
.||.|. ....
eqylflyrall

PTEN_1 607-661 6.5e-09 30.9 In-house 98-148 (196) alignment
Range on Protein: 607-661
Range on HMM: 98-148/196.0
HYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSakntNGPVIVHCSAGIGRSGTFI
.   ..|.|||. |.... . .. .  ... .    .. |.||| ||.||||| .
lhfpieDhgapslselfdicksfiewllsdpn....gnvVlVHCkaGlgRsGtvv

subfamily_DSP23_pd Subfamily DSP23 629-710 3e-06 22.0 In-house 70-140 (148) alignment
Range on Protein: 629-710
Range on HMM: 70-140/148.0
MVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISINInmAKIErfgndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFK
.|.  .    |.. |  | |||  | ||.||...  .   | .         ...  ... |.||.| | |.|..|   ...
vvefvrvveeaeekneavsvhcllgrgrtgtmlacyl..vker.........klaaaeaiaevrrlrpgsvetveqeklvrd

subfamily_CG42327_pd Subfamily CG42327 633-713 2.5e-16 54.2 In-house 237-312 (319) alignment
Range on Protein: 633-713
Range on HMM: 237-312/319.0
FKARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
  .| . .. .||..|||| |.||.|. |. .|.. ..|      |.  . | . |  .||.|   |.| .|| ||.||. 
issrsgtresqGPlvvhcsdGvGrtGlviasdiairslee.....skrsvdiPqlvssvrrdrasavltkeqyefiykvls

PTPc_motif_SM00404 638-661 2.6e-06 22.4 In-house 75-98 (140) alignment
Range on Protein: 638-661
Range on HMM: 75-98/140.0
SAKNTNGPVIVHCSAGIGRSGTFI
.|....| |.||| ||. ||.|.|
naekkggkvlVHCqaGvSRSatli

DSPc Dual specificity phosphatase, catalytic domain 638-661 3.7e-06 21.8 Pfam-A 68-91 (133) alignment
Range on Protein: 638-661
Range on HMM: 68-91/133.0
SAKNTNGPVIVHCSAGIGRSGTFI
.|.. .. |.||| ||| ||.|.|
kaeqkgkkvlVHCqaGisRSatli

DSPc Dual specificity phosphatase, catalytic domain 638-661 3.7e-06 21.8 In-house 68-91 (133) alignment
Range on Protein: 638-661
Range on HMM: 68-91/133.0
SAKNTNGPVIVHCSAGIGRSGTFI
.|.. .. |.||| ||| ||.|.|
kaeqkgkkvlVHCqaGisRSatli

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 647-714 5.6e-10 33.5 In-house 2-63 (69) alignment
Range on Protein: 647-714
Range on HMM: 2-63/69.0
IVHCSAGIGRSGTFISININMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
.||||.| ||.||||.| ..||.|       |.  . | . |  .|. |  ||    .||||   . .
vvhcssgtgrtgtfiaimvemarik......seklvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 647-715 1e-09 32.6 In-house 1-63 (69) alignment
Range on Protein: 647-715
Range on HMM: 1-63/69.0
IVHCSAGIGRSGTFISININMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
.||||.| ||.||||.| ..||.|       |.  . | . |  .|. |  ||   ..|.||   . . 
vvhcssGtGrtGtfiaimvemarik......seklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_ptpA1_pd Subfamily ptpA1 678-715 6e-06 20.2 In-house 360-397 (418) alignment
Range on Protein: 678-715
Range on HMM: 360-397/418.0
SQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
|.... .   ||.|| || |||| |.||.| .| | | 
sridfnlfsivlklreqrpgmvqqleqylfcyktilde