Gene DDB_G0290653 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP053_AA protein Get Run
DdisP053_AA_194-507 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_FIG4_pd Subfamily FIG4 55-514 8.2e-78 253.1 In-house 64-545 (569) alignment 
Range on Protein: 55-514
Range on HMM: 64-545/569.0
IRSCVKIFGCLGIINLLSGPFIICITDFETIGSIRETQILnRVAKHTITPIARIpiSLTEEEKKEEKNYLTLLNDLIESCDLYFSYNFDVTQSEQRASR-
..  |. .| ||.. .|.| ..| .|  .....| . .|  .. . .. .|..   |  .|.. .|. || |..|.  . ..|||| .|.|.. |  .  
lekkvsayGilGfvrflegyylilvtkrkkvaviGghaiy.kiedialikited..skksekssdearylklfkdvdltknfyfsysydltrtlqtnlll

---------IESNPLLMIQPLWKRCDRRFFWNYHLQQIFIENSFD-SFILPVMDGFIKITECEINNNQFKYIFISRRSCKRTGARYHIRGADPLGNVANF
          |..   .|.    . . .| || .| ... ..    ...| .. ||.. .. ..  .. . ..|.||| | .|||.  ||..  |.||| 
sdsnrekekaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvane

VETEQIV-------LFDQVLTSFVQVRGSIPLIWQQKGKGLKPRPIVEnsVQTDDAF----TSHMNELIQLYG-PTVIISLIDQ---IGGEASIGDAFES
|||||||       | .. ..||||.|||.|| |.|    |...| ..  ... | |    ..|...|.| || |..|. |. .      |. .  .||.
veteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpik..idvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefea

ETL----LMYPKEMVKYVAYDFHEKCKNNRYDRLSELLNSVKPLVDQYGYLFKSTmiGIEPTIQQSGCFRTNCIDCLDRTNVVQSVLAHYILHSQLTRMG
       .. ... .||...|.. . |..  . |. | .  .  | . |......   .|.|. |.|  ||||.|||||||. | |.... |  ||...|
aieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsap..dlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslG

IIgANERIEDHQQFETQFKNIWADNADVMSEQYTGTVALKTDFTRTGKRSVKGTMTDGVNSVRRYINKNFKDDEKQSAIDLFLGKYIVEK
|| .. ..| . .  . ..... |  | .. ||.|.   .|  | .  .. .    | .....||.   |.| .||.||.||||.|  ..
ii.desklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspre
Sac_COG5329 56-553 3.6e-116 380.6 In-house 56-567 (1070) alignment 
Range on Protein: 56-553
Range on HMM: 56-567/1070.0
RSCVKIFGCLGIINLLSGPFIICITDFETIGSIRETQILNRVAKHTITPIARIPISLTEEEKkEEKNYLT--------LLNDLIESCDLYFSYNFDVTQS
.|  .|.|.||.|.|    |.| ||. .  . ... .  ... .. . .. .      |.|. .| .. .         | .|      |||..||.|..
ssaheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeies.deasteklrsehpcselkkLlsngsFYfStdfditnt

EQRASRIesnpllMIQPLWKRCDRRFFWNYHLQQIFIEN-----S-----FDS--FILPVMDGFIKITECEINNNQFKYIFISRRSCKRTGARYHIRGAD
 |. ..       . .. ... |..|.||  | . .|..     |     .|   |. .|  ||..    ......     ||||| || |.|.  || |
Lqkrlke......elelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvD

PLGNVANFVETEQIVLFDQVLTSFVQVRGSIPLIWQQ-KGKGLKPRPIVENSVQ-TDDAFTSHMNELIQLYGPTVIISLIDQIGGEASIGDAFESETLlM
  |||||||||||||   |. .||.|||||||..| |  ..  .|.  . .|.. | .||  |  .|.. ||. .|. |... . |...  ..|..    
ddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlk.l

YPKEMVKYVAYDFHEKCKNNRYDRLSELLNSVKPLVDQYGYLFKSTMIGiEPTIQQSGCFRTNCIDCLDRTNVVQSVLAHYILHSQLTRMGIIGANERIe
 .|. .... .||| .......|... ||. ..  . . || ....  | . . .|.| |||||.||||||||.|....  .|  |.. ...|.| .   
sekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkeg.kliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde.

dhqQFETQFKNIWADNADVMSEQYTGTVALKTDFTRTGKRSVKGTMTDGVNSVRRYINKNFKDDEKQSAIDLFLGKYIVEKWSSDLSS-----TSSSLAE
   .| ......||||.|  |..|||| |||..|||.||||..| . | ..||.|... || | |||.||||.|||.  .. .... .     .  .   
...dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeavelydpineyvnlrlrks

STSITQEYNVLIITDSFILENISNT
.. .|...||.|.| .|   . | .
eseftaaknvsiftltfnsngesss
subfamily_SAC1_pd Subfamily SAC1 57-515 1.2e-201 661.2 In-house 3-458 (458) alignment 
Range on Protein: 57-515
Range on HMM: 3-458/458.0
SCVKIFGCLGIINLLSGPFIICITDFETIGSIrETQILNRVAKHTITPIARIPISLTEEEKKEEKNYLTLLNDLIESCDLYFSYNFDVTQSEQRASRIeS
..|||.|.||||.||||...|.||..|..|.| ......|||...|.|... ..|||||.|||||.||.||.....|...||||..|.|.| ||.... .
evvkiagilGiikLlsgkylivitkkeevgri.ngkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekv.t

NPLLMIQPLWKRCDRRFFWNYHLQQIF-IENSFDSFILPVMDGFIKITECEINNNQFKYIFISRRSCKRTGARYHIRGADPLGNVANFVETEQIVLFDQV
.. |. ..|..|.|.|||||.||.. .  |....||||||..|||||.|...|....|.|.|||||..|.|.||..||.|  |||||||||||||.... 
saalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaeka

LTSFVQVRGSIPLIWQQKGK-GLKPRPIVENSVQTDDAFTSHMNELIQLYGPTVIISLIDQIGGEASIGDAFESeTLLMYPKEMVKYVAYDFHEKCKNNR
|||||||||||||.|.||..  .||.. ...| ...|||..|..|.|.|||..|...|.|| | |...|.|.|| .. ...|...||||.|||..|...|
ltsFvqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayes.vvralnkkkikyvafDFHkeCrkmr

YDRLSELLNSVKPLVDQYGYLFKSTMIGiePTIQQSGCFRTNCIDCLDRTNVVQSVLAHYILHSQLTRMGIIGANERIEDHQQFETQFKNIWADNADVMS
.|||..|...... ..|.||..||..     . .|.|..||||||||||||||||.||...|..||...|.. .....||....||.|||.|||||| .|
wdrlklLidqlekelsqegyflkseekk..ivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavs

EQYTGTVALKTDFTRTGKRSVKGTMTDGVNSVRRYINKNFKDDEKQSAIDLFLGKYIVEKW
.||.||.||||||||||||...|...||||||.||...||.|.|.|..||||||||.||..
vqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrvets
subfamily_Synaptojanin_pd Subfamily Synaptojanin 59-539 2.4e-88 288.4 In-house 4-461 (754) alignment 
Range on Protein: 59-539
Range on HMM: 4-461/754.0
VKIFGCLGIINLLS----GPFIICITDFETIGSIRETQILnRvakhtITPIARipISLTEEEKKEekNYLTLLNDLIESCDLYFSynfdVTQSEQRASRI
| ..|.||...| .      |.. .|. . .| | ...|. .     || .    .|| .| ..|  .... |. |..|  .|||    .......   .
vdaygllGvlrlnagdetlsflvlvtgcksvGkisdaeif.k.....itstel..vslrseasde..driielkkllasgtfyfs....ssadsasrldl

ESNPLLmiQPLWKRCDRRFFWNYHLQQIFIEN--SFDSFILPVMDGFIKITECEINNNQFKYIFISRRSCKRTGARYHIRGADPLGNVANFVETEQIVLF
 ..     .   .  | |||||  |   .     . |...|.|| | ..|    . ..| | ..||| ||.|.| |...||..  |||||||||||..|.
slsaqr..rkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvill

DQVLTSFVQVRGSIPLIWQQKGKGLKPRP--IVENSVQTDDAFTSHMNELIQLYGPTVIISLIDQIGGEASIGDAFESETLLMYPKEMVKYVAYDFHEKC
|. .|||||.|||.|| |.| |     .   .  .   .  ||  |...| . || .||..|. . .||. . .||...      .. |..| .|.|.|.
ddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkv

KNNRYDRLSELLNSVKP-LVDQYGYLFKStmiGIEPTIQQSGCFRTNCIDCLDRTNVVQSVLAHYILHSQLTRMGiigANERIEDHQQFETQFKNIWADN
| .. . |..||. .    ...... ...   | | . .|.|  |.||.||||||| ||.||.  .|..||  ..    ... .  ..||  ||..|  |
kggkkeklekllkkqlklflesasfflsk...gkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk...lsskesvvsrfeevfkslWskn

ADVMSEQYTGTVALKTDfTRTGKrsvkgtMTDGVNSVRRYINKNFKDDEKQSAIDLFLgkyIVEKWSSDLSSTSSSLAESTSITQEYNVL
 | .|. |.|| ||... ....|      . ||  || | |..|| |  || ||||.|   . . ....|.. ...| .|... .  ..|
GdeiskiyaGtgalegk.akvsk......lkdgarsvartiqnnfldsskqeaidlll...lgntyveeladkarallkssllrasakil
Syja_N SacI homology domain 61-356 3.2e-86 280.4 Pfam-A 1-318 (319) alignment 
Range on Protein: 61-356
Range on HMM: 1-318/319.0
IFGCLGIINLLSGPFIICITDFETIGSIRETQILNRVAKHTITPIARIPISLT------EEEKKEEKNYLTLLNDLIESCDLYFSYNFDVTQSEQRASRI
..|.||.|.|||. ... ||. | ...||... . .. .  ..|. . . . .      |||.|||...|.||..|..|  .||||..|.|.| || |. 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

ESNPLL---MIQPLWKRCDRRFFWNYHLQQIFIENS--FDSFILPVMDGFIKITECEIN-NNQFKYIFISRRSCKRTGARYHIRGADPLGNVANFVETEQ
|..        .||.|..|.||.||..|.. .|| .   ....||.. ||......|.. ....... |||||.|| |.||  ||.|  |||||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVLF--D--QVLTSFVQVRGSIPLIWQQ-KGKGLKPRPIVE-NSVQTDDAFTSHMNELIQLYGPTVIISLIDQIGGEASIGDAFESETLLM----YPKEM
|| .  .  . ..||||.|||.||.|.| ..  |||.. .. .| .. .||..|...||. ||. |...|... |.|. ...|.|..   .      |. 
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

VKYVAYDFHEKCKNNRYD
.||...|||..||.....
lkyiefDfhkeckgkkfe
Syja_N SacI homology domain 61-356 3.2e-86 280.4 In-house 1-318 (319) alignment 
Range on Protein: 61-356
Range on HMM: 1-318/319.0
IFGCLGIINLLSGPFIICITDFETIGSIRETQILNRVAKHTITPIARIPISLT------EEEKKEEKNYLTLLNDLIESCDLYFSYNFDVTQSEQRASRI
..|.||.|.|||. ... ||. | ...||... . .. .  ..|. . . . .      |||.|||...|.||..|..|  .||||..|.|.| || |. 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

ESNPLL---MIQPLWKRCDRRFFWNYHLQQIFIENS--FDSFILPVMDGFIKITECEIN-NNQFKYIFISRRSCKRTGARYHIRGADPLGNVANFVETEQ
|..        .||.|..|.||.||..|.. .|| .   ....||.. ||......|.. ....... |||||.|| |.||  ||.|  |||||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVLF--D--QVLTSFVQVRGSIPLIWQQ-KGKGLKPRPIVE-NSVQTDDAFTSHMNELIQLYGPTVIISLIDQIGGEASIGDAFESETLLM----YPKEM
|| .  .  . ..||||.|||.||.|.| ..  |||.. .. .| .. .||..|...||. ||. |...|... |.|. ...|.|..   .      |. 
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

VKYVAYDFHEKCKNNRYD
.||...|||..||.....
lkyiefDfhkeckgkkfe
subfamily_INPP5F_pd Subfamily INPP5F 113-546 7.5e-115 376.1 In-house 115-547 (951) alignment 
Range on Protein: 113-546
Range on HMM: 115-547/951.0
TEEEKKEEKNYLTLLNDLIESCDLYFSYNFDVTQSEQRASRIESNPLlmiQPLWkrcDRRFFWNYHLQQIFIENSFDS---FILPVMDGFIKITECEINN
..||.|.||  |  |. |... . |.|..||.|.. |. .  | .      . |   |.||||| .|.. .|...      |..||. ||... |..|..
qneeeklekrlleelkkllsdgsFYysldfDltntlqkrgleekses...tddw...derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisiek

NQFKYIFISRRSCKRTGARYHIRGADPLGNVANFVETEQIVLFDQVLTSFVQVRGSIPLIWQQKGKGLKPRPIVENSVQ-TDDAFTSHMNELIQLYGPTV
.....  ||||| || |.|.. || |  ||||||||||.|. . .   ||.|.|||.|. |.|.||  ||.. ...|.. |  ||. |..|... ||..|
lkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkkykpkikitrseeetqpaFdehfkeqlkkygkvv

IISLIDQIGGEASIGDAFESETlLMYPKEMVKYVAYDFHEKCKNNRYDRLSELLNSVKPLVDQYGYLFKSTMIgiEPTIQQSGCFRTNCIDCLDRTNVVQ
|..|..| . |  ...|.. .  | . .. |...  ||||...... . .|.|....|  . . || ..      .   .|.| |||||.||||||||||
ivnllsqkssekklskaykeql.lkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvke..kviseqkgvfRtnclDcldrtNvvq

SVLAHYILHSQLTRMGIIGANERIEDhQQFETQFKNIWADNADVMSEQYTGTVALKTDFTRTGKRSVKGTMTDGVNSVRRYINKNFKDDEKQSAIDLFLG
. ..  .|..|| ..|..  ...|.| ... ...|..|||| |..|.||.|| ||| |.||.|.|.. | . ||..|| ||  .|||| ..| .||| ||
qaiskavlelqleklglfepessidd.eellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllG

KYIVEKWSSDLSSTSSSLAEST-----SITQEYNVLIITDSFI
|   .. .     ....  | .     . |.  |. ... |. 
klpkqevvelidpkkeekeeelrekeekftetsninllvgsvn