Gene sac1 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP054_AA protein Get Run
DdisP054_AA_186-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 28-488 1.4e-113 371.9 In-house 43-498 (951) alignment 
Range on Protein: 28-488
Range on HMM: 43-498/951.0
KHSVKASISVGVPKNNEKVLTrIENVKGIIGCIQLvsgHYLMIFKEHNHVATVtGKKIYQMKDVELIPFfPNQQSLVSIPDQDAEEQHL-SMIRWLLSSE
   ..  . . . ... |.|.  |...|.|| |.|   .  .| .. . .  |  .| ... | .  .  .....  .  .....|..|   .. |||..
vvaiervakldlsekdskele.keectgligliel...egkiivatiegkskv.nnkkwdlididssgy.lqlkeekeqneeeklekrlleelkkllsdg

NFYFSYDYDFTLTLQRQYSTTTTTTSGSSlgercDSRFFWNEKYVTILSKEHGLG--DWILPITMGFVESKTL---GGTCQFTLISRRNLNRSGTRYNVR
.||.|.|.| | |||..  .    ..        |.|||||.  .  | . .      ...|.  ||||.|..     . . ||||||  .| |||.. |
sFYysldfDltntlqkrgleeksestddw.....derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrr

GIDKKGNVANNVETEQIIEIKENtFTSFVQVRGSIPLLWSQFpTLKYKPSVKFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAELKLGEAYEER
|||..||||| ||||.|.....    ||.|.|||.|. |.|  . |||| .|   .|.|. .| ..|||.. . || . .|||.. |. | ||..||.|.
GidddgnvAnfvEtElilsveky.vlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeq

VKSL--KDVHYVWFDFHSICKGMRYDKLSILMDQLKDDLKQYGFFFVEDG-KIVQKQQGVFRTNCIDNLDRTNVVQSLITRHSLENQMASvLNKQIPSTT
.. |  ||| .. ||||  ..|.. ...| |....|...|. |.|...   |....|.|||||||.| ||||||||. | .. || |.   |..  |...
llkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqlek.lglfepess

FKGDQFEYVFKNIWADHGDAISTQYSGTGALKNDFTRTGKRNFQGVLRDGENSVKRYYLNNFKDGFRQDS
 . ...   .|..|||.|||||.|| || ||| |.||.|.|.. ||| || .||.||||||||| .||. 
iddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkv
Sac_COG5329 36-493 4.2e-127 416.8 In-house 41-516 (1070) alignment 
Range on Protein: 36-493
Range on HMM: 41-516/1070.0
SVGV---PKNNEKVLTRIENVKGIIGCIQLVSGHYLMIFKEHNHV-ATVTGKKIYQMKDVELIPFFPNQQSLVSI--PDQDAEEQ----HLSMIRWLLSS
.|.|   .|.. ..|.  ....|..| |.|    .| .  .   | . . |..||   .|. |.   |.     |  . .. |..     .|  . ||| 
lvavselkkegfrslssaheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsn

ENFYFSYDYDFTLTLQRQySTTTTTTSgsslGERCDSRFFWNEKYVTIL----SKEHGLGD-------WILPITMGFVESKTLGG---TCQFTLISRRNL
  ||||.|.| | |||.. . . .  |     .. | .|.||. ... |    || . |         .. ..  ||.|.        |   ||||||  
gsFYfStdfditntLqkr.lkeelels....vdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSs

NRSGTRYNVRGIDKKGNVANNVETEQIIEIKeNTFTSFVQVRGSIPLLWSQFPTLKYKPSVKFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAE
.|.|||.. ||.|..||||| ||||||.. . .. .||.|||||||. |.|  .. ..|....... ..  .|...||..| . ||   .|||.. |. |
kragtRflarGvDddGnvanFVETEqIvyss.qycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssE

LKLGEAYEERVKSLKD--VHYVWFDFHSICKGMRYDKLSILMDQLKDDLKQYGFFF--VEDGKIVQKQQGVFRTNCIDNLDRTNVVQSLITRHSLENQMA
 .| |.||. .| ...  .|.. ||||. .. ...|... | .....||.. |.|.  |..||....|.|||||||.| ||||||.|.|| .  | .|. 
ieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfr

SVLNKQIPSTTfkgdQFEYVFKNIWADHGDAISTQYSGTGALKNDFTRTGKRNFQGVLRDGENSVKRYYLNNFKDGFRQDSYFLFT
|.   .  ..     .|   ....|||.||||| .|.|||||| .|||.||| . | |.|  .||.|.|.||| |. .||.. |..
sikvisaidde....dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllL
subfamily_FIG4_pd Subfamily FIG4 38-492 2.6e-83 271.3 In-house 55-537 (569) alignment 
Range on Protein: 38-492
Range on HMM: 55-537/569.0
GVPKNNEKVLTRIENVKGIIGCIQLVSGHYLMIFKEHNHVATVTGKKIYQMKDVELIPFFPNQQSlvsIPDQDAEEQHLSMIRWLLSSENFYFSYDYDFT
 . . |.. |..  .  ||.|......|.||..   ...||.. | .||...|..||.   ...     ...  |...| . . .  ..|||||| ||.|
sleeanrdglekkvsayGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskk...sekssdearylklfkdvdltknfyfsysydlt

LTLQRQYSTTTTTTSGSSLGERC-----------DSRFFWNEKYVTILSKEHGLGDWILPITMGFVESKT---LGGTCQFTLISRRNLNRSGTRYNVRGI
 |||   ... .... .   .|.           . .| ||.. . .|..     ||.| |. |||. ..   || . . |||.||  . .|.|.  ||.
rtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGv

DKKGNVANNVETEQII------EIKENTFTSFVQVRGSIPLLWSQF-PTLKYKPSVKFYGDEKENSQAlEQHFKQLHQLYGSTTV-VNLID---RKGAEL
..||.|||.||||||.      ..... ..||||.|||.|| |||   .|. || .|    .   |.|  .||..| | ||| .. .||.    ..  | 
nnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaa.alhfddlfqryGspiiilnlvkkkekrkres

KLGEAYEERVKSL-------KDVHYVWFDFHSICKGMRYDKLSILMDQLKDDLKQYGFFFVEDG-KIVQKQQGVFRTNCIDNLDRTNVVQSLITRHSLEN
.| |..|. .. |       | ..|. .|..   |    . |..| .  .. .|. |.|. ..  . .. |.|. ||||.| |||||. | .|.. .|  
illeefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgy

QMASVLNKQIPSTTFKGDQFEyVFKNIWADHGDAISTQYSGTGALKNDFTRTGKRNFQGVLRDGENSVKRYYLNNFKDGFRQDSYFLF
|. |.   . .. .|. |  . ...... |.|| .. ||.|.   ..  | .  ....   ||  ...|||| | |.|  .||.  ||
qlkslGiidesklefdsdvvr.lleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlf
subfamily_SAC1_pd Subfamily SAC1 49-494 6.8e-191 625.8 In-house 3-451 (458) alignment 
Range on Protein: 49-494
Range on HMM: 3-451/458.0
RIENVKGIIGCIQLVSGHYLMIFKEHNHVATVTGKKIYQMKDVELIPFFPNQQSLVSIpDQDAEEQHLSMIRWLLSSENFYFSYDYDFTLTLQRQYSTTT
..... ||.|.|.|.||.||........|....||.||...|||.||.  |..||..  ....|...|......|.||.|||||.||.| .|||....|.
evvkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslsltee.qkkeekeylkllelvlksetfYfsytydltnslqrlekvts

TTTSGSSLGERCDSRFFWNEKYVTILSKEHGLGDWILPITMGFVESKTL---GGTCQFTLISRRNLNRSGTRYNVRGIDKKGNVANNVETEQIIEIKeNT
.... .|| ||.|.|||||..... |.||..| ..|||...||...|.|   . ...|.|||||...|.||||.|||.||.|||||.||||||.|.. ..
aalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveae.ka

FTSFVQVRGSIPLLWSQFPTLKYKPSVKFYgDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAELKLGEAYEE--RVKSLKDVHYVWFDFHSICKGMR
.|||||||||||||||| |.|||||.||.. .......|...|......|||....|||.|.||.|.|||||||.  |... |...||.||||. |. ||
ltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmr

YDKLSILMDQLKDDLKQYGFFFV-EDGKIVQKQQGVFRTNCIDNLDRTNVVQSLITRHSLENQMAS--VLNKQIPSTTFkgDQFEYVFKNIWADHGDAIS
.|.|..|.|||...|.|.|.|.. |..|||..|.||.||||||.||||||||||..|..|..|..|  ||...   ..   ...|..|||.|||..||.|
wdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskleds..aeletsfknlwadnadavs

TQYSGTGALKNDFTRTGKRNFQGVLRDGENSVKRYYLNNFKDGFRQDSYFLFTN
.||.||||||.||||||||...|.|||| |||.||| |||.||.||||..||..
vqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflg
subfamily_Synaptojanin_pd Subfamily Synaptojanin 50-492 8.7e-89 289.9 In-house 3-431 (754) alignment 
Range on Protein: 50-492
Range on HMM: 3-431/754.0
IENVKGIIGCIQLVS----GHYLMIFKEHNHVATVTGKKIYQMKDVELIPFFPNQQSLvsipdqdaeeQHLSMIRWLLSSENFYFSYDYDFTLtlqrQYS
| .. |..| ..| .     ..|..  . . |  ... .|... ..||...  . .            .... .. ||.|..||||   | .     ...
ivdaygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasde..........driielkkllasgtfyfsssadsas....rld

TTTTTTSGSSLGERcDSRFFWNEKYVTILSK-EHGLGDWILPITMGFVESKTLG---GTCQFTLISRRNLNRSGTRYNVRGIDKKGNVANNVETEQIIEI
 ....   ..  .. |.|||||    . |.. .    ||.|.. .| || .|.     . . .||||   .|.|||.||||....||||| |||||.| .
lslsaqrrkqeese.dnrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvill

KEnTFTSFVQVRGSIPLLWSQFPTLKYKPSVKFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAELKLGEAYEERVKS---LKDVHYVWFDFHSI
 . . |||||.|||.||.|.|      .  ||.  . . .. | ..|..||.. ||....|||. .|..|  | .|.... |.    |||..| ||.|. 
dd.kvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqk

CKGMRYDKLS-ILMDQLKDDLKQYGFFFVEDGKIVQKQQGVFRTNCIDNLDRTNVVQSLITRHSLENQMASVLnkqIPSTTFKGDQFEYVFKNIWADHGD
.|| . .||. .|  |||  |....||. ........|.|| |.||.| ||||| ||.... . ||.|.. .    . | . . ..|| |||..|   ||
vkggkkeklekllkkqlklflesasfflskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk...lsskesvvsrfeevfkslWsknGd

AISTQYSGTGALKNDfTRTGKrnfqgvLRDGENSVKRYYLNNFKDGFRQDSYFLF
 ||. | |||||. . ....|      |.||. ||.|   ||| |. .|..  |.
eiskiyaGtgalegk.akvsk......lkdgarsvartiqnnfldsskqeaidll
Syja_N SacI homology domain 53-345 9e-96 311.7 Pfam-A 1-318 (319) alignment 
Range on Protein: 53-345
Range on HMM: 1-318/319.0
VKGIIGCIQLVSGHYLMIFKEHNHVATVTG-KKIYQMKDVELIPFFPNQQSLVSIP-----DQDAEEQHLSMIRWLLSSENFYFSYDYDFTLTLQRQYST
..||.|.|.| |..||.. .. ..||.. | ..||. |.||.||.  ....   |      ....||. |.... ||||..|||||||| | .|||....
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

TTTTTS----GSSLGERCDSRFFWNEKYVTILsKEHG--LGDWILPITMGFVESKTLGGT----CQFTLISRRNLNRSGTRYNVRGIDKKGNVANNVETE
......      .| ...|.||.||.. .. | .| .  | .|.||.  ||||....       ...||||||. .|.||||. ||||..||||| ||||
eeeekeeeskslpllkevderFvWNrnllkpl.ielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtE

QIIEIK---ENTFTSFVQVRGSIPLLWSQFPTLKYKPSVKFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAELKLGEAYEERVKSL-------K
||...|   .....||||.|||.||.|.| ..|..||..|.. .......|...|||.| . ||. .||||...|| | ||.||||| ...|       |
qivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekk

DVHYVWFDFHSICKGMRYD
...|..||||. |||....
klkyiefDfhkeckgkkfe
Syja_N SacI homology domain 53-345 9e-96 311.7 In-house 1-318 (319) alignment 
Range on Protein: 53-345
Range on HMM: 1-318/319.0
VKGIIGCIQLVSGHYLMIFKEHNHVATVTG-KKIYQMKDVELIPFFPNQQSLVSIP-----DQDAEEQHLSMIRWLLSSENFYFSYDYDFTLTLQRQYST
..||.|.|.| |..||.. .. ..||.. | ..||. |.||.||.  ....   |      ....||. |.... ||||..|||||||| | .|||....
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

TTTTTS----GSSLGERCDSRFFWNEKYVTILsKEHG--LGDWILPITMGFVESKTLGGT----CQFTLISRRNLNRSGTRYNVRGIDKKGNVANNVETE
......      .| ...|.||.||.. .. | .| .  | .|.||.  ||||....       ...||||||. .|.||||. ||||..||||| ||||
eeeekeeeskslpllkevderFvWNrnllkpl.ielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtE

QIIEIK---ENTFTSFVQVRGSIPLLWSQFPTLKYKPSVKFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDRKGAELKLGEAYEERVKSL-------K
||...|   .....||||.|||.||.|.| ..|..||..|.. .......|...|||.| . ||. .||||...|| | ||.||||| ...|       |
qivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekk

DVHYVWFDFHSICKGMRYD
...|..||||. |||....
klkyiefDfhkeckgkkfe