Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
ubiquitin | Ubiquitin family | 86-150 | 5.9e-09 | 24.7 | Pfam-A | 4-66 (69) | alignment | ||
Range on Protein: 86-150
Range on HMM: 4-66/69.0
NGKEYKVLISKSSTVFDLKRQLETMTNVLSKRQKILglSKGKQPTDEMIIESLSIQDNHSIIMMG
.||.... ...|.|| .|| ..| ... .|... .||. |. .. . |||.......
sgktitlevepsdtvselKekieekegipvdqqrLi..ysGkvLeDdrtlsdyniqdgstlhlvl
|
|||||||||
CPDc_SM00577 | 214-361 | 5.7e-16 | 50.8 | In-house | 1-143 (146) | alignment | |||
Range on Protein: 214-361
Range on HMM: 1-143/146.0
NKKLLVLDLDHTILDF-------KDQDV------E-----NMKRPHLEEFLVQSYQHYDIGIWSQTSWKWIEikltelglltnprfKICFVMDQTLMFKV
.||.||||||.|.. . ..| .|||...||| . ...... |....| |... .|. ..| . ..|
kkkvLVlDLdetLvhsanmaepksfsevsptdslaetlvlvlkRPyvdeFLkkaaklfelvifTsaskkyad..............tildllDpkrllky
T-TYRTINGKERTKikHNVKALEVIWKhqhlgkffSMKNTLHVDDLSKNFAMNPKNGVHVPPFKIKD
|| . ...| .. . |..... ...... .|. ......||.| . ..|.. .
rvlyRqdcrlvkgk..llkddlsllkv........dlskvviiDnseestlvnpenalkikpyisal
|
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subfamily_UBLCP1_pd | Subfamily UBLCP1 | 216-361 | 8.9e-69 | 219.6 | In-house | 1-137 (138) | alignment | ||
Range on Protein: 216-361
Range on HMM: 1-137/138.0
KLLVLDLDHTILDFKD--QDVENMKRPHLEEFLVQSYQHYDIGIWSQTSWKWIEIKLTELGLLTNPRFKICFVMDQTLMFKVTT--YRTINgkertkikh
||||||.|.|.|||.. .|....|||.|||||...|..|||.|||.||.||||.||.|||...||..||.||.|.|.|.|||| |..|.
kllvldvdytlldfrsvaedalelkrpyleefltsayedydiviwsatsmkwievklkelGvadnpnykiafvldstamikvttpkygvie.........
nVKALEVIWKhqHLGKFfSMKNTLHVDDLSKNFAMNPKNGVHVPPFKIKD
||||.|||| .|.|| |.|||...|||..||.||||||....|||..|
.vkalgviwk..klekf.sskntimfddlrrnflmnpknGlkirpfkead
|
|||||||||
NIF | NLI interacting factor-like phosphatase | 216-386 | 1.2e-24 | 79.0 | Pfam-A | 1-158 (159) | alignment | ||
Range on Protein: 216-386
Range on HMM: 1-158/159.0
KLLVLDLDHTILDFKD--------------QDVENMKRPHLEEFLVQSYQHYDIGIWSQTSWKWIEIKLTELGlltnprfkicfvmDQTLMFKVTTYRTI
|.||||||.|... | .... |||.|.||| . ..|.. |....|....| | .| . .|| ||
ktLVLDLDetLvhskekkdlkedgkkveektkasvkkRPgldeFLkelskayevviftasskeyaepvldkld.............pkkklfkkrlyres
NGkERTKiKHnVKALEVIwkhqhlG-KffsMKNTLHVDDLSKNFAMNPKNGVHVPPFKIKDakkYGDNVLFHLTKYLKSISNEEDI
| . |. || |... | . ..... ||| ...|...|.||....||. .. |. | .|...|.......|.
ct.lrng.ky.vKdLsll......grd...lsrvvivDdsprsfelqpdngipiepfygds...dkdtellkllpflealeksddv
|