Gene CG13197 in Drosophila melanogaster

Synonym: BcDNA:RE27552, Dmel\CG13197, Dmel_CG13197, CG13197

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP016_AA protein Get Run
DmelP016_AA_13-173 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP11_pd Subfamily DSP11 5-175 8e-78 254.4 In-house 1-175 (178) alignment 
Range on Protein: 5-175
Range on HMM: 1-175/178.0
IPDRWLKYKPIGDRVPGTRFIAFKVPLNQHVNAKVKENLRLAPESLLQIVPD----MGLIIDLTNTNRYYHPSAITNHDVLHQKLMIPGKQTPSHKLAQR
.|||| ||||.||...||||||||.||......||.|. |..|..||... .    .||.||||||.|||.....|...| ..||..||...|...|...
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkk

FCAFVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIERDNYLSSLKTLPN
|...|..|||.|.||||||||||||||||||||||...|.|....||.||..|. ||||..||.|||..||.| .
fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklek
0038934 (Phosphotyrosine protein) phosphatases II 5-173 8.4e-49 161.2 In-house 2-172 (194) alignment 
Range on Protein: 5-173
Range on HMM: 2-172/194.0
IPDRWLKYKPIGDRVPGtRFIAFKVPLNQHVNAKVKENLRLAPESLLQIVP----DMGLIIDLTNTNRYYHPSAITNHDVLHQKLMIPGK-QTPSHKLAQ
.|||||||...||...| |||||||||.....  ..| .|..||.|.. ..    ..||.||||||.|||.|. ...... . ||..|..  .|| .. .
lPdrwlkyervgdiitg.rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

RFCAFVTDFLerNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIERDNYLSSLKTL
||. .| .||  |.|......|||..|..|||.|.. ..| ...||.||||..|. .|.. |.. .||. | . 
rfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_RNGTT_pd Subfamily RNGTT 6-171 2.1e-39 129.2 In-house 1-168 (189) alignment 
Range on Protein: 6-171
Range on HMM: 1-168/189.0
PDRWLKYKPIGDRVpGTRFIAFKVPLNQHVNAKVKENLRLAPESLLQIVP----DMGLIIDLTNTNRYYHPSAITNHDVLHQKLMIPGKQT-PSHKLAQR
|.|||.    |  .   .|..|| || .. . .. |. |  |. ||. .      .||.||||||.|||. ........ ..|| . ||.  |..   ..
PerWlnCPrkgkli.aekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FCAFVTDFLERNAdnDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIERDNYLSSLK
|   |..| ..|.  ...|||||||| ||||.||. ... ....| |.|...|. ||   | ...||. | 
fiklveeffkknp..eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkell
PTEN_1 6-162 1.6e-19 65.5 In-house 16-176 (196) alignment 
Range on Protein: 6-162
Range on HMM: 16-176/196.0
PDRWLKYKPIGDRVPGTR-FIAFKVPLnQHVNAKVKENLRLAPESLLQIVPDM-GLIIDLTNTNRY----YHPSAITNHDVLHQKLMIPGKQTPSHKLAQ
|...| ...| .|. ..  . . ...  ..   . ...|..... | .  .|   |...|..   .    |...   ...| . ...|.  ..||    .
ptelldltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslself

RFCAFVTDFLERNADnDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIE
..|. . . | .. .  . . |||..|..|.| ... .... ......||.. .  .| .   
dicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgap
0036282 (Phosphotyrosine protein) phosphatases II 7-170 6.5e-27 89.7 In-house 2-162 (174) alignment 
Range on Protein: 7-170
Range on HMM: 2-162/174.0
DRWLKYKPIGDRVPGTRFIAFKVPLNqHVNAKVKENLRLAPESLLQIVPDMGLIIDLTNTNRYYhpsaITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVT
...... |..  .  .|.||...||. ..    .....     |  . ......|......|..     ..... ...|..|. ..|.    ..|. || 
sdyinaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsillefvkfve

DFLERnaDNDKLIGVHCTHGVNRTGYLICYFMISVMNM-SPEEAIQTFSLAR---GHEIERDNYLSSL
..|..  |... . |||..||.|||.|.. ... .. . |...|....  .|   .. .......  |
ealse..dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
0040438 (Phosphotyrosine protein) phosphatases II 16-172 5e-21 70.7 In-house 16-270 (317) alignment 
Range on Protein: 16-172
Range on HMM: 16-270/317.0
GDRVP----------------------------------------------------------------GTRFIAFKVPLNQHVNA---KVKENlrlape
. ...                                                                ...|||...||.. |.     |.|.      
dftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq......

sllqivpDMGLIIDLTNTNRY----------------------YHPSAITNHDVLHQKLMI-------------------PGKQTP-SHKLAQRFCAFVT
       . ..|. ||..  .                       . | ...... . .|..                   |   .| |..| ..|. .| 
.......gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

DFLErnaDNDKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIERDNYLSSLKT
..||   |... . |||..||.|||..|. ...       .....|||....  .|.. ..  ...  | .
eale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0041856 (Phosphotyrosine protein) phosphatases II 19-166 3e-23 77.8 In-house 31-159 (182) alignment 
Range on Protein: 19-166
Range on HMM: 31-159/182.0
VPGTRFIAFKVPLNQhvnakvkenlrlAPESLLQIVPDMGL--IIDLTntNRYYHPSAITNHDVLHQKLMIPGKQTPShklAQRFCAFVTDFLErnadND
 |.|||||...||..             ... |. . ..|   |..||  ...| |.  ... . ...| .|.  .|.    . ...|. . ||    ..
lpatrfiatqgplls............tvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd...ldelldfieevle....eg

KLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIERDNY
. . |||..||.|||.|...... ....|.|||....  .| . ... |.
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnq
0045450 (Phosphotyrosine protein) phosphatases II 20-170 1.2e-16 56.8 In-house 105-296 (307) alignment 
Range on Protein: 20-170
Range on HMM: 105-296/307.0
PGTRFIAFKVPLNQhvnakvkenlrlAPESLLQIVPDM--GLIIDLTNTNR-------YYHPSAitNHDVLHQKLMI-----------------------
 ...|||...||..             .|. .. . .   ..|..||..          | |.   .. . . .. .                       
lkrkfIatqgPlpe............tvedFwrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldg

---------------PGKQTPS-HKLAQRFCAFVTDFLERNaDNDKLIGVHCTHGVNRTGYLICYFMISVMN--------MSPEEAIQTFSLARGHEIER
               |. ..|.  . . .|.  | ..||.. .... . |||..||.|||..|. ... ..         ....||....   |.. .. 
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn

DNYLSSL
 ...  |
peqyrfl
0037934 (Phosphotyrosine protein) phosphatases II 21-167 1e-22 76.3 In-house 44-231 (243) alignment 
Range on Protein: 21-167
Range on HMM: 44-231/243.0
GtRFIAFKVPLNQHVNAKVKENLRLAPESllqivpDMGLIIDLTNTN----------------------------------------RYYHPSAITNHDV
. |.||. .||.. |. .. ...|.  |       . . |..||..                                         ... ..  | ...
p.rliatqgPlpetveddlasfwrmlwel......gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

LHQKLMIPGKQTPS-HKLAQRFCAFVTDFLER-----NADNDKLIGVHCTHGVNRTGYLICYFMISVM-NMSPEEAIQTFSLARGH-EIERDNYL
 .. | .|. ..|. ..  ..|. .|..|.|.     ..|... . |||..||.|||.||.....  . ....|||....   |..  ..  ...
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy
0040439 (Phosphotyrosine protein) phosphatases II 21-171 2.6e-19 65.2 In-house 53-239 (249) alignment 
Range on Protein: 21-171
Range on HMM: 53-239/249.0
GTRFIAFKVPLNQhvnakvkenlrlAPESLLQIVPDMG--LIIDLTNTNRY-------------------------------------------YHPSAI
..||||.. ||..            . |. .. . . |   |..||.. ..                                           |... .
krrfiatqgPlpe............tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesr

TNHDVLHQKLMiPGKQTPSHKLAQRFCAFVTDFLERNaDNDKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIERDNYLSSL
| . . . ..    .  || . . .|.  | ..||.. .... . |||..||.|||..|. ...        ....|||....  .|.. .. ....  |
tvlhiqytdwp.dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

K
 
y
0045098 (Phosphotyrosine protein) phosphatases II 21-160 8e-19 63.5 In-house 63-254 (278) alignment 
Range on Protein: 21-160
Range on HMM: 63-254/278.0
GTRFIAFKVPLNQHVNA------------------------------------KVKENLRLAPESLLQIvpDMGLIIDLTNTNRYYHPSAITNHDVLHQK
...|||.  ||.. |..                                    .. .....  .|  ..  |.  ...|. || ..... .... | | .
pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlh

L-MIPGKQTPSHKLAQRFCAFVTDFLERNA-------------DNDKLIGVHCTHGVNRTGYLICYFMISVM---NMSPEEAIQTFSLARGH-E
.  .|   .||. . . |  ..   .|...             |... . ||| .||.||| |.. ...  .   .....||....   |..  
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpgla
0043336 (Phosphotyrosine protein) phosphatases II 21-170 1.7e-18 62.5 In-house 87-269 (278) alignment 
Range on Protein: 21-170
Range on HMM: 87-269/278.0
GTRFIAFKVPLNQHV--------NAKVKENLRLAPESLL-------------------------QIVPDMGLIIDLTNTNRYYHPSaitNHDVLHQKLMI
...|||.. ||.. |        . .|.  ..| ..  |                         ... |   ...|. ||.....|    . . .. | .
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges...rtvthyhylgw

PGKQTP-SHKLAQRFCAFVTDFLErnaDNDKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIERDNYLSSL
|  ..| | .| ..|. .| ..||   |... . |||..||.|||..|. ...     .  ....|||....   |.. .. ....  |
pdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0039614 (Phosphotyrosine protein) phosphatases II 21-170 3.2e-18 61.7 In-house 100-281 (297) alignment 
Range on Protein: 21-170
Range on HMM: 100-281/297.0
GTRFIAFKVPLNQHVN---AKVKENlrlapesllqivpDMGLIIDLTNTNRY--------------YHPSAITNHDVLHQKLMI----------------
. .|||.. ||.. |.     |.|.             .   |. ||... .              |..  .|. .| | . ..                
trkfIatqgPlpetvedFwrmvweq.............gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvt

-------PGKQTP-SHKLAQRFCAFVTDFLERNaDNDKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIERDNYLSSL
       |  ..| |..| ..|. .| ..|... .... . |||..||.|||..|. ...     .  .....||....  .|.. .. ....  |
hfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0046846 (Phosphotyrosine protein) phosphatases II 22-165 2.2e-18 62.1 In-house 23-160 (176) alignment 
Range on Protein: 22-165
Range on HMM: 23-160/176.0
TRFIAFKVPLNQHVNAKVKENLRLapesllqivpDMGLIIDLTNTN------RYYHPSAITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVTDFLERNadn
 |.||.  ||.. . . ... ..|          . .....||.         ..... ...... .. | .|  ..|...| .....|. ..|...   
srpiatqgplprtladflemlkel..........gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg...

dKLIGVHCTHGVNRTGYLICYFMISV-MNMSPEEAIQTFSLARG-HEIERDN
 . . ||| .|..||| |.. ...   ...|.|||....   |  . .. ..
.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpe
subfamily_CDC14_pd Subfamily CDC14 22-158 5.4e-11 36.9 In-house 178-305 (328) alignment 
Range on Protein: 22-158
Range on HMM: 178-305/328.0
TRFIAFKVPlnqHVNAKVKENL-RLAPESLLQIVPDMGLIIDLTNTNRYYHPSAITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVTDFlernadnDKLIG
 .|.|.  |   | ..|....    |||.||.   . ..   .   .. |. .  |.. . |. |.     |||... ..| . . .        .  | 
dkflalagP...hnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.......eGaia

VHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARG
|||  |. ||| ||  ...   ... .|||  . ..| 
vhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
0042113 (Phosphotyrosine protein) phosphatases II 23-170 1.4e-19 66.0 In-house 53-235 (245) alignment 
Range on Protein: 23-170
Range on HMM: 53-235/245.0
RFIAFKVPLNQHVNA---KVKENlrlapesllqivpDMGLIIDLTNTNRYYH-----------------------------------------PSAITNH
.|||.  ||...|..    ..|.             .   |..||..  . .                                         ..  . .
kfiatqgPlpetvedfwrmlwel.............gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesre

DVLHQKLMIPGKQTPS-HKLAQRFCAFVTDFLERnaDNDKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIERDNYLSSL
.. .. | .|. ..|. ..| ..|. || ..|..  |... . |||..||.|||..|. ...     . ...|.|||.. .   |.. .. ....  |
vihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl
0049772 (Phosphotyrosine protein) phosphatases II 34-171 4.2e-20 68.1 In-house 157-267 (314) alignment 
Range on Protein: 34-171
Range on HMM: 157-267/314.0
HVNAKVKENLRlapesllqivpdmgliidltntNRYYHPSAITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVTDFlernaDNDKLIGVHCTHGVNRTG-Y
. .|.  |.|.                      ...| |.  ... . .  . .|. ..|. .  ..|..|. ..     |... . |||..|..||| .
eptaadlellk......................eelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtf

LICYFMISVMNMSPEEAIQTFSLARGhEIERDNYLSSLK
........ ...|.|||.. . |.|     ..... .|.
vvaaylmkllgvsleealedvrlkRp.inpnpgfieqle
0049260 (Phosphotyrosine protein) phosphatases II 48-167 2.6e-19 64.9 In-house 23-139 (152) alignment 
Range on Protein: 48-167
Range on HMM: 23-139/152.0
ESLLQIVPDMGLIIDLTNTNRYYHPSAITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVTDFLerNADNDKLIGVHCTHGVNRTGYLICYFMISvMNMSPE
.. .. . ..|  . .. |.... .   ...   .. | .|   .|..    .|.  . ..|  . |... . |||..||.||| |......  ...|.|
adfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsle

EAIQTFSLARGHEIERDNYL
||.. .  .| . ..  ..|
eavalvrekRpgavpnpgql
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 53-176 1.9e-07 24.7 In-house 28-146 (148) alignment 
Range on Protein: 53-176
Range on HMM: 28-146/148.0
IVPDMGLiIDLTNTNRyYHPSAITNHDVLHqkLMIPGKQTPSHKLAQRFCAFVtDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQT
 . ..|.   . |...  .. |. .. . .  | .. .  | . | . |  .. .|...  |. . . ||.. || |   |   ..|   ..| .||.. 
alkalgv.trivnatk.erdnaldqrgieY..lhvaldDkpkedlsaiFedii.afvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealal

FSLARGHEIERDNYLSSLKTLPNR
   .| .  ..  .|. |  | ..
vkskrryvdpnlgfLkqLaeleqa
subfamily_DSP23_pd Subfamily DSP23 54-162 2e-08 29.0 In-house 27-130 (148) alignment 
Range on Protein: 54-162
Range on HMM: 27-130/148.0
VPDMGLIIDLTNTNRYYhPSAITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVTDFLERNadndKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTF
. |.|.   .. |..   | . .  ..  ..| |.  . |. .  ..|   | .  |.|    . ..|||  |  ||| ..  ...   ...  |||   
lldlgvrylvslteegr.phveatpnltlvrlriddyhppaleqvvefvrvveeaeekn....eavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

SLARGHEIE
   |   .|
rrlrpgsve
0044763 (Phosphotyrosine protein) phosphatases II 57-171 1.3e-20 69.2 In-house 49-164 (178) alignment 
Range on Protein: 57-171
Range on HMM: 49-164/178.0
MGLIIDLTNTNRYY----HPSAITNHDVLHQKLMIPGKQTPS-HKLAQRFCAFVTDFLErnaDNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQ
 ..|..||.. ...    .| . ..... .... ||.  .|.  .  ..|..|. ..|.   .... . |||..||.|.|.|.. ... ....|.||||.
ithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaie

TFSLARGhEIERDNYLSSLK
 .  .|   ......|  |.
lvrerRp.ivpnpgqlrqLy
DSPc Dual specificity phosphatase, catalytic domain 57-172 9.5e-18 59.4 Pfam-A 19-129 (133) alignment 
Range on Protein: 57-172
Range on HMM: 19-129/133.0
MGLIIDLTNTNRYYhpsaITNHDVLHQKLMIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLA
. |.|..|....      .. ..   ..| || ... . |... . . ...|.|. ... | . |||..|..|...||...... .|.| .||.. ..  
itlvinvtkevpnn....naikkseieylripvedetetkiskelee.avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RGHEIERDNYLSSLKT
|..  .....| .|  
rskispnagflrqLle
DSPc Dual specificity phosphatase, catalytic domain 57-172 9.5e-18 59.4 In-house 19-129 (133) alignment 
Range on Protein: 57-172
Range on HMM: 19-129/133.0
MGLIIDLTNTNRYYhpsaITNHDVLHQKLMIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLA
. |.|..|....      .. ..   ..| || ... . |... . . ...|.|. ... | . |||..|..|...||...... .|.| .||.. ..  
itlvinvtkevpnn....naikkseieylripvedetetkiskelee.avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RGHEIERDNYLSSLKT
|..  .....| .|  
rskispnagflrqLle
0043147 (Phosphotyrosine protein) phosphatases II 58-170 7.6e-20 66.8 In-house 46-153 (172) alignment 
Range on Protein: 58-170
Range on HMM: 46-153/172.0
GLIIDLTntNRYYHPSAITNHDVLHQKLMIPGKQTPSHKLAQRFCAFVTDFLerNADNDKLIGVHCTHGVNRTGYLICYFMISvMNMSPEEAIQTFSLAR
..|..||  ...| |.  . ... .. | .|   .|. .| ..|. |. ..|  . .... . |||..||.|||.|......  ...|.|||....  .|
thivnlt..ellydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekR

GHEIERDNYLSSL
.. .. ....  |
pgavqnpsqyrfl
0048179 (Phosphotyrosine protein) phosphatases II 58-171 2.7e-19 64.8 In-house 31-138 (144) alignment 
Range on Protein: 58-171
Range on HMM: 31-138/144.0
GLIIDLTNTnryYHPSAITNHDVLHQKLMIPGKQTPSH-KLAQRFCAFVTDFLErnadNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLA
...|.||..   |.|   ... . ...| .|. ..|.. .| ..|..|. ..||    ... . |||..||.|||.|...... ....|.|||.. .  .
ttvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsr

RGHEIERDNYLSSLK
| . .. ...|  |.
rpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 58-171 1.2e-18 62.7 In-house 31-136 (145) alignment 
Range on Protein: 58-171
Range on HMM: 31-136/145.0
GLIIDLTNTNRYYHpsaitNHDVLHQKLMIPGKQTPSH-KLAQRFCAFVTDFLERnadnDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLA
.....||.. ...      .... .. | .|. ..|.  .| ..|..|. ..|..    .. . |||..||.|||.|.. ...  ...|.|||.. .  .
ttvlnltselelle.....rlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsq

RGHEIERDNYLSSLK
| . ......|  |.
rpgavpnpgqlrfly
0051082 (Phosphotyrosine protein) phosphatases II 58-161 1.4e-15 52.7 In-house 35-136 (151) alignment 
Range on Protein: 58-161
Range on HMM: 35-136/151.0
GLIIDLTNTN-RYYHPSAITNHDVLHQKLMIPGKQTPShklAQRFCAFVTDFLERNADN-DKLIGVHCTHGVNRTGYLICYFMISvMNMSPEEAIQTFSL
  |..|...  |.|.|.  ..... .  . |.. ..|.    . . ..| .|||  .|. .. . |||..|..||| |.. ...  ...|.|||.. . |
ktivnlrseeergycpeylpelgievlhipildwpdpg...lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrl

ARGHEI
 |.. .
krpgvv
PTPc_motif_SM00404 59-171 2.4e-15 51.6 In-house 30-135 (140) alignment 
Range on Protein: 59-171
Range on HMM: 30-135/140.0
LIIDLTNTNRYYhpsaitNHDVLHQKLMIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARG
..|..|.. .        ...   | | || ... . ||.. . . |.||.|. ... . . |||..||.|...||...... ...| .||.. ..  | 
hvinvteevslt......kensgfqilqiplddnekdklskyldk.vldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRp

HEIERDNYLSSLK
.  .. |.. .| 
iispnlnfvrqLi
0051429 (Phosphotyrosine protein) phosphatases II 59-165 4.1e-11 38.5 In-house 48-212 (272) alignment 
Range on Protein: 59-165
Range on HMM: 48-212/272.0
LIIDLTNTNRYYHPS-AITNHDVLHQKLMIPGKQTPSH------------------------------------------------KLAQRFcafVTDFL
 |.||.... . .       ... .  | |..  .|..                                                  .|     . ..|
tivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea...llell

E---RnadnDKLIGVHCTHGVNRTGYLICYFMISvMNMS--------------PEEAIQTFSLARGHEIERDN
|   .    .. . |||..|..||| ... ...  ...|              .|||..    .| . .. . 
ellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
subfamily_VSP_pd Subfamily VSP 66-166 1.3e-09 32.2 In-house 83-179 (212) alignment 
Range on Protein: 66-166
Range on HMM: 83-179/212.0
TNRYYHPSAItNHDVlhQKLMIPGKQTPSHKLAQRFCAFVTDFLERnaDNDKLIGVHCTHGVNRTGYLICYFMI-SVMNMSPEEAIQTFSLARGHEIERD
..| | .. . |. |  ....|  .. |. .    |.  | ..||.  |..... .||  | .||| ..| ... | .  . .|... |.  | .. | .
seraydekyf.nnrv..kriliddhnvpkleellvftkevkewlek..dlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktege

NY
..
kf
subfamily_PTEN_pd Subfamily PTEN 67-159 5.3e-11 37.8 In-house 70-158 (184) alignment 
Range on Protein: 67-159
Range on HMM: 70-158/184.0
NRYYHPSAItNHDVLHQklMIPGKQTPSHKLAQRFCAFVTDFLErnADNDKLIGVHCTHGVNRTGYLICYFMISVM-NMSPEEAIQTFSLARGH
.|.|  . . .. | .    .  ...|. .| ....  ....||  .|..... |||  |  ||| ||. ...  .   ..|||.. |. || .
erkydskkf.dgrvavy..pfdDhnppplelleeivediekwle..edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk
subfamily_Auxilin_pd Subfamily Auxilin 67-159 1.8e-07 24.0 In-house 58-146 (166) alignment 
Range on Protein: 67-159
Range on HMM: 58-146/166.0
NRYYHPSAITNhDVLHQKlmIPGKQTPSHKLAQRFCAFVTDFLERnaDNDKLIGVHCTHGVNRTGYLICYFMISV-MNMSPEEAIQTFSLARGH
.| |... ...  |....  .| ...|. .   . |. .  .|..  |. . . |||. |.  .. |.. ... . .  .||.|.. ||. |  
qrtyrtaklss.rvveag..wparraPnLeslvevcrnlyswlkk..dpknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlp
0048567 (Phosphotyrosine protein) phosphatases II 68-161 3.5e-16 53.9 In-house 26-122 (157) alignment 
Range on Protein: 68-161
Range on HMM: 26-122/157.0
RYYHPSAI-TNHDVLHQKLMIPGKqTPSHKLAQRFCAFVTDFLERNADNDKLIGVHCTHGV---NRTGYLICYFMISVMNMSPEEAIQTFSLARGHEI
..|..  . .......  .  .    ..  .  ||.  . .||.    ..| | |||..|     ||..||. ..| .....|||||. ....| . .
slynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
0051299 (Phosphotyrosine protein) phosphatases II 72-163 7.5e-10 34.2 In-house 177-271 (288) alignment 
Range on Protein: 72-163
Range on HMM: 177-271/288.0
PSAITNHDVLHQKLMIPGKQTPS-HKLAQRFCAFVTDFLErnaDNDKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIER
..  . .   .. . .|  ..|.  .|  .|. .| ..|.   .... . ||| .||.||| .|. ...         ....||....   | . .. 
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
subfamily_DSP10_pd Subfamily DSP10 72-157 1.5e-06 22.2 In-house 51-133 (159) alignment 
Range on Protein: 72-157
Range on HMM: 51-133/159.0
PSAITNHDVLHQKlmIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLAR
|   ..... ...  || . | ...| |.| .   .|.|    ... . |||  |. |   ..  ...  .|.| ..| .  . .|
PnefeeealkYkr..ipvsDtskqnlkqyfee.alefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekr
0046845 (Phosphotyrosine protein) phosphatases II 76-164 1.7e-11 39.5 In-house 164-260 (284) alignment 
Range on Protein: 76-164
Range on HMM: 164-260/284.0
TNHDVLHQKLMIPGKQTP-SHKLAQRFCAFVTDFLERnADNDKLIGVHCTHGVNRTGYLICYFMISVM--------NMSPEEAIQTFSLARGHEIERD
. .   .. . .|  ..| | .  ..|. .| ..||.  .... | ||| .||.|||..|.  ..  .        .....||.. .   | . ..  
srtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0050432 (Phosphotyrosine protein) phosphatases II 78-163 3.9e-10 35.0 In-house 161-284 (308) alignment 
Range on Protein: 78-163
Range on HMM: 161-284/308.0
HDVLHQKLMI-------------------------------------PGKQTPSH-KLAQRFCAFVTDFLernadNDKLIGVHCTHGVNRTGYLICYFMI
. . . |. .                                     |  ..|.. .   .|. .| ..|     ... | ||| .||.||| .|.  ..
gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdll

-----SVMNMSPEEAIQTFSLARGHEIER
        .....||....   | . .. 
leqlekeggvdvfeavkklReqRpgmvqt
0047943 (Phosphotyrosine protein) phosphatases II 80-164 5.7e-11 37.9 In-house 169-258 (273) alignment 
Range on Protein: 80-164
Range on HMM: 169-258/273.0
VLHQKLMIPGKQTP-SHKLAQRFCAFVTDFLERNADNdKLIGVHCTHGVNRTGYLICYFMI-----SVMNMSPEEAIQTFSLARGHEIERD
  .. . .|  ..| | .   .|. .| ..|| . .| . . ||| .||.||| .|. ...        .....||.. .   | . ..  
thfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 83-167 1.2e-09 33.3 In-house 174-266 (297) alignment 
Range on Protein: 83-167
Range on HMM: 174-266/297.0
QKLMIPGKQTPS-HKLAQRFCAFVTDFLeRNADNDKLIGVHCTHGVNRTGYLICYFMI--------SVMNMSPEEAIQTFSLARGHEIERDNYL
. . .|   .|. ..   .|. .| ..| ... ... . ||| .||.|.| .|. ...           .... ||....   | . ..  . .
hytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqy
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 83-154 1.3e-06 21.5 In-house 48-118 (145) alignment 
Range on Protein: 83-154
Range on HMM: 48-118/145.0
QKLMIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFS
. |.|  ..  |. |.| |   ||||...  ..   . |||  || |.  .   |..   ||.  || .   
eillitaedlesydlsqhfde.vtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvr
subfamily_DSP12_pd Subfamily DSP12 84-171 6.3e-07 23.9 In-house 51-137 (155) alignment 
Range on Protein: 84-171
Range on HMM: 51-137/155.0
KLMIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIERDNYLSSLK
...|.   .|.  . . .   ..||.|   .... . |||. || |   ..  ...   ..| |.|... . .. .    ...|. ||
tkfiqilDepeediLshlde.avdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLk
subfamily_DSP15_pd Subfamily DSP15 85-157 1.2e-06 22.7 In-house 48-119 (151) alignment 
Range on Protein: 85-157
Range on HMM: 48-119/151.0
LMIPGKQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLAR
..|. . ||| || . |     .|. .   ... . |||  || |   |.  ....|.... ..|...   ||
kciaasDtpsaklskffke.svefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaR
PTPc_DSPc_SM00012 87-155 4.3e-09 31.9 In-house 10-78 (105) alignment 
Range on Protein: 87-155
Range on HMM: 10-78/105.0
IPGKQTPSHKlaQRFCAFVTDFLERNADND--KLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSL
.| ...|..   . .. .. .. . . ...  | . ||| .||.|||....  ..  .... .. .. | .
wpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqi
subfamily_DSP3_pd Subfamily DSP3 87-157 8.1e-06 19.6 In-house 68-138 (162) alignment 
Range on Protein: 87-157
Range on HMM: 68-138/162.0
IPGKQTPSHKLAQRFcAFVTDFLERNADN-DKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLAR
.. . .|. .| . |   ...|...  .. .  . |||. || |   |.  ... . .|.  |||.|    |
levdDvpefdlskyF.etaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR
Y_phosphatase Protein-tyrosine phosphatase 90-157 3.2e-06 22.1 Pfam-A 146-210 (235) alignment 
Range on Protein: 90-157
Range on HMM: 146-210/235.0
KQTPSHklAQRFCAFVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMIsVMNMSPEEAIQTFSLAR
...|..  .. .  ..... ........ . ||| .||.||| ...  .. ..... || .. ... .
hgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil.leqleaeeevdvlqivk
Y_phosphatase Protein-tyrosine phosphatase 90-157 3.2e-06 22.1 In-house 146-210 (235) alignment 
Range on Protein: 90-157
Range on HMM: 146-210/235.0
KQTPSHklAQRFCAFVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMIsVMNMSPEEAIQTFSLAR
...|..  .. .  ..... ........ . ||| .||.||| ...  .. ..... || .. ... .
hgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil.leqleaeeevdvlqivk
subfamily_DSP19_pd Subfamily DSP19 90-155 7.9e-06 20.3 In-house 64-128 (152) alignment 
Range on Protein: 90-155
Range on HMM: 64-128/152.0
KQTPSHKLAQRFCAfVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSL
  .| ..| . . . ..||.|   ..|  . |||  || |.  ..  ....  ..| |||...   
lDlpetdllsylke.aldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvre
DSPn Dual specificity protein phosphatase, N-terminal half 99-154 2.6e-06 18.2 Pfam-A 50-108 (141) alignment 
Range on Protein: 99-154
Range on HMM: 50-108/141.0
QRFCAFVTDFLERNADNDKLIGVH-CTHGVNR--TGYLICYFMISVMNMSPEEAIQTFS
 |||  ... |.. . ..| | .  ...  .|  . .||. ... |...|||||.. ..
yrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspeealkple
subfamily_PTPDC1_pd Subfamily PTPDC1 114-167 1.2e-08 29.6 In-house 113-165 (182) alignment 
Range on Protein: 114-167
Range on HMM: 113-165/182.0
DNDkLIGVHCTHGVNRTGYLICYFMISVMNMSPEEAIQTFSLARGHEIERDNYL
...  ..|||  |  ||| ||. ... . ....|.||..    | . |.  . .
qeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqv