Gene MKP-4 in Drosophila melanogaster

Synonym: CG14211, DMKP-4, Dmel\CG14211, Mkp4, Dmel_CG14211, MKP-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP017_AA protein Get Run
DmelP017_AA_36-183 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 32-178 1.1e-23 79.1 In-house 35-189 (196) alignment 
Range on Protein: 32-178
Range on HMM: 35-189/196.0
FDGGPV-SidEVDTGLFLGNLTAA-THMETLRSFKITHILTLDSVP------LPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALA--QQGN
. . |. .  |.| ||..|.|. .  . ..| . .||....|.. .       .  . ..| .. . . | | .  .. .... |..||...|.  ....
apsrpllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnv

VLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
|||||  |..||   |.||.|....|..  | |||..|| .. || ..  .|. . .
VlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa
0037934 (Phosphotyrosine protein) phosphatases II 32-176 1.3e-20 69.5 In-house 32-237 (243) alignment 
Range on Protein: 32-176
Range on HMM: 32-237/243.0
FDGGPVSIDEVDTGLFLGNL--------TAATHMETLRSFKITHILTLDSVP------------------------------------------LPQHIL
 |  . .  .|  .|.....        ..|.. . | . .||.|..| .                                            |.   |
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

EASFLTTKYIQIAD----MPREDILQHLEGCVDFISS-----ALAQQGNVLVHCYFGVSRSSSTVIAYMMKRH-NLDFLPAYELVKAKRRF-VQPNAGFV
.       |. . |       ||.|..|. . .||..     || ..| |||||. ||.|.   ..||.|... ..|.. |..|....| . . .. .. 
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

SQLKLF
 .|  .
rflyea
subfamily_DSP1_pd Subfamily DSP1 33-177 4.4e-35 115.2 In-house 16-153 (163) alignment 
Range on Protein: 33-177
Range on HMM: 16-153/163.0
DggPVSidEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVpLPQHILEasFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSR
|  ||   ..   |.||  | |...|.|.| .||.|| . .  |...  .   .. | ... | |..|| ...|  ..|| .. ...| ||.||  |.||
d..Pve..kildfLylGsetvasnleiLkslgitailnvske.ldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisR

SSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR
||. ..||.||.... .  |...|| .|  ..|||||| ||. . 
sstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnye
0045098 (Phosphotyrosine protein) phosphatases II 33-179 1.5e-25 85.6 In-house 16-270 (278) alignment 
Range on Protein: 33-179
Range on HMM: 16-270/278.0
DGGPVSIDEVDTGLFLGNLT-----------------------------------------AATHMETLRSFKITHILTLDSV-----------------
   . ...|. ..|.||||                                          .| . ..|.. .||.|..| ..                 
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

------------------------------PLPQHILEASFLTT--KYIQIADMPREDILQHLEGCVDFISSALA--------------QQGNVLVHCYF
                                .... .. .     . .   . | ..||...  ...|| .||.              ..| |||||. 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVSRSSSTVIAYMMKRH---NLDFLPAYELVKAKRRF-VQPNAGFVSQLKLFRRM
||.|.   |.||.|...   ..|.| |.. .. .|.. ...| ..  .|  | ..
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0043147 (Phosphotyrosine protein) phosphatases II 35-179 5.8e-28 93.2 In-house 15-159 (172) alignment 
Range on Protein: 35-179
Range on HMM: 15-159/172.0
GPVSIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREdILQHLEGCVDFISS--ALAQQGNVLVHCYFGVSR
... .|..  ...... | | . . |.. .||||..| .  ..   || . ..  |. . |..   .|..|. ...|| .  || ..| |||||. ||.|
lyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgR

SSSTVIAYMMKrHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
.   |.||.|. ..|... |..||..||. . .| ..  .|. | ..
tgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
0046846 (Phosphotyrosine protein) phosphatases II 35-178 1.2e-25 85.7 In-house 8-170 (176) alignment 
Range on Protein: 35-178
Range on HMM: 8-170/176.0
GPVSIDEVDTGLFLGNLT----------AATHMETLRSFKITHILTLDSV--------PLPQHILEASFLTTKYIQIADMPREDIlQHLEGCVDFISSAL
 . ..|... .|.||..            |.  | |.. .||....| .         |   ..||.  .. ... . |.   |. ..|. ...|| .||
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

AQQGNVLVHCYFGVSRSSSTVIAYMMKR-HNLDFLPAYELVKAKRR-FVQPNAGFVSQLKLFRR
 . |.|||||. |..|.   |.||.... ..|. . |..||...|. .. .. ... .|. | .
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0051082 (Phosphotyrosine protein) phosphatases II 35-174 3.1e-22 74.2 In-house 4-147 (151) alignment 
Range on Protein: 35-174
Range on HMM: 4-147/151.0
GPVSIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVP---LPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQ-QGNVLVHCYFGV
..  .  |. ||....   | ..|.|.. .|..|..| | .      ..|..  .. ..|.| |.|  .. .... ...|.. .|.. .|.|||||  |.
dyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGk

SRSSSTVIAYMMKrHNLDFLPAYELVKAKRR-FVQPNAGFVSQLK
.|.   |..|.|. .....  |.| ...||  .|||| .|. ||.
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0044763 (Phosphotyrosine protein) phosphatases II 36-183 5e-35 116.1 In-house 20-173 (178) alignment 
Range on Protein: 36-183
Range on HMM: 20-173/178.0
PVSIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPL------PQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSAL-AQQGNVLVHCYF
.  ..|.. ||.||.| .| . | |.  .||||..| .         ..  .|   .. ..| | |..  |.|.|.. .|.|| .||  ..|.|||||. 
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsa

GVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRfVQPNAGFVSQLKLFRRMGCKI
||.|| . |.||.||...|..  |.|||...|. ..|| |.. ||..| .. .| 
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
0036282 (Phosphotyrosine protein) phosphatases II 36-178 1.8e-22 75.3 In-house 9-167 (174) alignment 
Range on Protein: 36-178
Range on HMM: 9-167/174.0
PVSIDEVDTGLFLGNLTAAtHMETLRSFKITHILTLDSVPLPQ------------HILEASFLTTKYIQIADMPREDILQhLEGCVDFISSALAQ--QGN
|... .. ..|..|.  .| ..| |....||....| .   ..            . || . .. .|. . |.   |. . |. .|.|. .||..  .| 
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

VLVHCYFGVSRSSSTVIAYMMKRHNL-DFLPAYELVKAKR---RFVQPNAGFVSQLKLFRR
|||||  ||.|.   |.||.|.|. | ..  |..||...|     . .. ..  .|  |..
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0042113 (Phosphotyrosine protein) phosphatases II 37-176 9.3e-19 63.3 In-house 45-238 (245) alignment 
Range on Protein: 37-176
Range on HMM: 45-238/245.0
VSIDEVDTGLFLGNLTAATHME----TLRSFKITHILTLDSVPLP-------------------------------------------QHILEASFLTTK
|. ...  ......  .. . |     |.. .||.|..| .                                               ..  .   ..  
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

YIQIADMPREDILQHLEGCVDFISSALA--QQGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF
|. . |..  |.|..|. ...|. .|||  ..| |||||  ||.|.   ..||.|     |......  |.. .. .|. . .. ..  .|  .
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_DSP19_pd Subfamily DSP19 38-176 9.8e-39 127.1 In-house 11-146 (152) alignment 
Range on Protein: 38-176
Range on HMM: 11-146/152.0
SIDEVDTGLFLGNLTAATHMETLRSFKITHILTLdSVPLPQHIleASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTV
.. ||   |.||   .|.. |.|.. |||||| . .. .|..   .. .|.. |.| | | .|.|..|. ..||| .|. ..| |||||  |||||.| |
evgeveprlylgsqdvaadkeilkekkitHilnv.atgvpnvf..pkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv

IAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF
|||.||...|..  |.|||...|. ..||.||. ||| .
iaylmkkeelsleealelvrearpcikPneGFikqLkey
subfamily_DSP14_pd Subfamily DSP14 38-176 1e-32 107.3 In-house 6-140 (157) alignment 
Range on Protein: 38-176
Range on HMM: 6-140/157.0
SIDEVDTGLFLGnLTAATHMETLRSFKITHILTLDSvPLPQHILEAsfLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTV
.. ..   |||.  .||.. |.|.. |||.|. .    ||.. |.   . .  ....|.|.... .|..  .| | .. ...|..||||. ||||| | .
alsqitpsLfls.gvaalskellkkkkitliinvtv.elpntklkd..iervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

IAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF
.||.|| ..|    ||.|||..|  ..|| || .||  .
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidy
subfamily_DSP3_pd Subfamily DSP3 38-174 1.1e-29 97.2 In-house 10-151 (162) alignment 
Range on Protein: 38-174
Range on HMM: 10-151/162.0
SIDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLT---TKY--IQIADMPREDILQHLEGCVDFISSALAQ-QGNVLVHCYFGVS
..|||  .|..|. ..|.. . |. . |||.|      . .   .|.| .    ||  ... |.|. |. .. |  ..|| .||.| .| |||||  |||
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSSSTVIAYMMKRHNLDFLPAYELVKAKRRfVQPNAGFVSQLK
||.  |.||.| |....   | . |..||. ..|| ||. ||.
RsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLa
0041856 (Phosphotyrosine protein) phosphatases II 38-183 6.3e-29 96.3 In-house 18-175 (182) alignment 
Range on Protein: 38-183
Range on HMM: 18-175/182.0
SIDEVDTGLFLGNLTA--------------ATHMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREDilqhLEGCVDFISSALAQQGNVL
 .|..  .|.||.| |              | . ..|.. .||.|..| ... .   ||   .. .|... |..  |    |. ..|||  .|...|.||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRR--FVQPNAGFVSQLKLFRRMGCKI
|||  ||.|. . |.||.||......  |..||. .|   ...|| .|. ||.|. .. .|.
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP12_pd Subfamily DSP12 39-191 1.4e-61 201.4 In-house 2-154 (155) alignment 
Range on Protein: 39-191
Range on HMM: 2-154/155.0
IDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI
......||.||.|.|....|.|...||||.|.... .||.| |... ..||.|||.|.|.||||.||. .||||..||...|.|||||..|||||...||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRMGCKIDPNCQRYK
||.||...|..  |..|||.|.. ..||.||..|||||..||||.| . . ||
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayk
subfamily_DSP15_pd Subfamily DSP15 39-178 1.6e-32 106.7 In-house 2-137 (151) alignment 
Range on Protein: 39-178
Range on HMM: 2-137/151.0
IDEVDTGLFLGNLTAATHMETLRSFKITHILTLDSvpLPQHILEAsfLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI
|..| .||.|||.. . . | |.  .|||||..     ....|.   .. |.|...| |  .. .... .|.|| ..  ...||||||  |||||   |.
iskvlpglylgnfrdskdeelLkeknithilsvhd..nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvv

AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
||.|   .|..  | | .||.|   .||.|| .||| . .
aYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0048076 (Phosphotyrosine protein) phosphatases II 39-178 9.3e-32 105.0 In-house 4-140 (145) alignment 
Range on Protein: 39-178
Range on HMM: 4-140/145.0
IDEVDTGLFLGNLTAATHMETLRSFKITHILTLdsvPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI
..|.. ||.||.|..| ..|.|....||..|.|      .. ||.  ..  |. . |..  |.|..|. ...|| .||.. |.|||||. ||.|. . |.
pseilpglylgslptaldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
||.|.......  |.|||...|... || |.. .|..| .
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_STYX_pd Subfamily STYX 39-178 2.4e-25 82.5 In-house 12-155 (166) alignment 
Range on Protein: 39-178
Range on HMM: 12-155/166.0
IDEVDTGLFLGNLTAAT--HMETLRSFKITHILTLDSVPLPQhILEASFL-TTKY--IQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRS
..|.  |||||  .||   ..|.|..  ||||. .   .  . ..   |  . .|  ...|| . |.|...|    .|| ..| . |.||||   |.|||
mqeilpglflgpysaamksklevlkkhgithivcirqniean.likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

SSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
.. ||||.|. . | .  |.  |. .|  ..||.||||||| .. 
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP8_pd Subfamily DSP8 39-177 1.7e-24 80.2 In-house 15-151 (159) alignment 
Range on Protein: 39-177
Range on HMM: 15-151/159.0
IDEVDTGLFLGNLTAATHMETLRSFKITHILTLDS-VPLPQHILEASFLTtkyIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTV
. ..   |.||  . . . |.|.   |...| ..   | .. . |. ||    . . |   |..|. ..  |.||  | ...|.||||.. | |||.. .
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflr...vPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

IAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR
|||.||. ....  ||. || ||  ..||  |. ||  . 
iayimktlemsldeayrfvkekrptispnlnflgqLleye
PTPc_motif_SM00404 40-179 6.7e-34 111.8 In-house 3-140 (140) alignment 
Range on Protein: 40-179
Range on HMM: 3-140/140.0
DEVDTGLFLGNLTAATHMETLRSFKITHILTLDS-VPLPqhiLEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVI
 ..  .|.||....|.. . | ...|||.. . . |.|.    | |  . . |.. |   ......|. ..|||..| ...|.|||||. ||||| . .|
srilphlylgskskaqnpallkklgithvinvteevslt...kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii

AYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
||.|....|.   |||.|| .|  ..||..|| ||  ....
aYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
0048179 (Phosphotyrosine protein) phosphatases II 40-177 3.9e-31 103.1 In-house 5-141 (144) alignment 
Range on Protein: 40-177
Range on HMM: 5-141/144.0
DEVDTGLFLGNLTAATHMETLRSFKITHILTLDSvPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIA
.|.. ||.||.| .| ..|.|....||....| . . ... ||   ..  .. . |..  |.|..|. ...|| .||.. |.|||||. ||.|. . |.|
seilpglylgslptaldlellkklgittvinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR
|.||...|..  |..||...| .. || |.. .|....
ylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_LRR-DSP_pd Subfamily LRR-DSP 40-177 4.9e-29 95.2 In-house 121-255 (263) alignment 
Range on Protein: 40-177
Range on HMM: 121-255/263.0
DEVDTGLFLGNLTAATHMETLRSFKITHI-LTLDSVplpQHILEASFlttKYI---QIADMPREDILQHLEGCVDFISSAlAQQGNVLVHCYFGVSRSSS
||.  .|||| | .|.    |..  .||| |..  .   . .    |   ||.   .| |... || ||.|    || .   ..| |||||  ||||||.
deiidklflGgldsannksilkdlgvthillavadf...ePlfPklf...kylsiddiedvdeadisqhfeetnafieeG.rkkGGvlvhcraGvsrsst

TVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR
 ||.|.||...| |  |..||. ||  .||| ||. ||| . 
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkye
subfamily_STYXL1_pd Subfamily STYXL1 42-176 5e-19 62.1 In-house 15-149 (157) alignment 
Range on Protein: 42-176
Range on HMM: 15-149/157.0
VDTGLFLGNLTAATHMETLRSFKITHIL--TLDSVPLPQHILEASflTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIA
. . |.|||   |.. .  . .|.   .  . |. .| . . ...      |.. | .. |.|..|.  |.|| .   ..  |||    |.||| . .||
lPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadva..kllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviia

YMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF
|.|  ... .  ||. .|  .  |.|| .||.||. .
ylmyskkitlkkaykylkkCkenvkPnrafveqlseW
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 43-175 8.7e-27 87.5 In-house 12-142 (148) alignment 
Range on Protein: 43-175
Range on HMM: 12-142/148.0
DTGLFLGNLTAATHMETLRSFKITHILTLDSvpLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMM
|. ||||.   |...|.|. . .|.| .       . .|.   .    ....| |.||. .  |  ..|.. | .. . ||||.  ||||||  ......
dafLFlGskksaadlealkalgvtrivnatk..erdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwli

KRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKL
. ..     |..||| |||.|.|| ||..||  
dfkrvslkealalvkskrryvdpnlgfLkqLae
0049772 (Phosphotyrosine protein) phosphatases II 43-179 7.3e-26 87.0 In-house 155-272 (314) alignment 
Range on Protein: 43-179
Range on HMM: 155-272/314.0
DtglflgNLTAATHMETLRsfkithiltldSVPLPQHILEASFLTTKYIQIADmPREDILQHLEGCVDFISSAlAQQGNVLVHCYFGVSRSSS-TVIAYM
       |.  | ..|.|.           ..  ... .|   .. ..| . | . ...|.... ...|| .|  ..|.|||||  |..|. .  |.||.
g......neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaayl

MKRHNLDFLPAYELVKAKRRfVQPNAGFVSQLKLFRRM
||......  |.| |..||  ..|| ||. ||...  .
mkllgvsleealedvrlkRp.inpnpgfieqleqyefi
subfamily_DSP10_pd Subfamily DSP10 44-178 1.6e-31 103.3 In-house 19-151 (159) alignment 
Range on Protein: 44-178
Range on HMM: 19-151/159.0
TGLFLGNLTAATHMETLRSFKITHILTLDSVpLPQHILEaSFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMK
. ||||. . |.....|. ..||..| . .  .|..  | . |. | |.. |  .... |. |  ..||  |  .. .|||||  |.|||.. ||||.||
pfLflGsekdaadldaldrlnitavlnvtts.vPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmk

RHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
. || .  ||..|| ||  . || .|. ||. | .
hlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP6_pd Subfamily DSP6 44-179 5.4e-29 94.7 In-house 19-153 (158) alignment 
Range on Protein: 44-179
Range on HMM: 19-153/158.0
TGLFLGNLTAATHMETLRSFKITHILTLDSvPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMK
. |.||. ..|. .|.|. .|| ..| . |  ||.   |.  |. . | | |   ... ...   ..||  |  .. .|||||. |.|||   ..||.||
pllylGsakdasnlevlkklkikyvlnvts.nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmk

RHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
...| .  ||.|||...  . ||  |. ||. | |.
klalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_MKPLT_pd Subfamily MKPLT 44-179 2e-26 86.5 In-house 27-159 (164) alignment 
Range on Protein: 44-179
Range on HMM: 27-159/164.0
TGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTtkyIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMK
  |.|||   ||  . |.  |||||. .    . .      .|.   ... | . | . ..||   .|...|.   | |||||  |.|||||. .|...|
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlq...vkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

RHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
 .   .  ||| .| .|  |.|| ||. ||  | ..
skgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 44-179 2e-26 86.5 In-house 27-159 (164) alignment 
Range on Protein: 44-179
Range on HMM: 27-159/164.0
TGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTtkyIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMK
  |.|||   ||  . |.  |||||. .    . .      .|.   ... | . | . ..||   .|...|.   | |||||  |.|||||. .|...|
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlq...vkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

RHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
 .   .  ||| .| .|  |.|| ||. ||  | ..
skgwtlkeayeylkerrsivapnrGflkqlakfeel
0049260 (Phosphotyrosine protein) phosphatases II 44-176 6.6e-26 86.2 In-house 13-145 (152) alignment 
Range on Protein: 44-176
Range on HMM: 13-145/152.0
TGLFLGNLTAATHMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISS-ALAQQGNVLVHCYFGVSRSSSTVIAYMM
 ....|. |.| . . |.. .||.|..| .     .. ..   . ..... |..  |. |.|. ...||   || ..|.|||||. ||.|.   |.||.|
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

KrHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF
. ...... |..||..||  . || |.  .|. |
l.lgvsleeavalvrekRpgavpnpgqlrflyef
subfamily_Slingshot_pd Subfamily Slingshot 45-178 4.1e-29 95.1 In-house 25-155 (169) alignment 
Range on Protein: 45-178
Range on HMM: 25-155/169.0
GLFLGNLTAATHMETLRSFKITHILTLDSvPLPQHiLEASFlTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR
 ..||    |. .| |.. ....|| .    . ..  . .| . . |.. | ...|.|.. .   .||. | ... .|||||  |||||.|||||| ||.
hvylGsewnasnleelkengveyilnvtk.eidnf.fpekf.eylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamke

HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
..|..  |.| || .|. ..||.||..||. .. 
yglsleealeyvkerrsvikPnkgflkqleeyeG
DSPc Dual specificity phosphatase, catalytic domain 46-178 2.3e-29 96.9 Pfam-A 1-132 (133) alignment 
Range on Protein: 46-178
Range on HMM: 1-132/133.0
LFLGNLTAAThMETLRSFKITHILTLD-SVPLPqHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR
|.||. ..|.  . |  ..||... .  .|| . .  . |  .   |.. |.  ..| ..|| .|.||..| .....|||||. |.||| . .|||.||.
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
.||.   |||.|| .|  . |||||. ||  ..|
knlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 46-178 2.3e-29 96.9 In-house 1-132 (133) alignment 
Range on Protein: 46-178
Range on HMM: 1-132/133.0
LFLGNLTAAThMETLRSFKITHILTLD-SVPLPqHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR
|.||. ..|.  . |  ..||... .  .|| . .  . |  .   |.. |.  ..| ..|| .|.||..| .....|||||. |.||| . .|||.||.
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

HNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
.||.   |||.|| .|  . |||||. ||  ..|
knlslneAyefvkerrskispnagflrqLleyer
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 46-177 1.4e-25 83.4 In-house 10-149 (154) alignment 
Range on Protein: 46-177
Range on HMM: 10-149/154.0
LFLGNLTAATHMETLRSFKITHILTL---DSVPLPQH---ILEASFLTTKYIQIADMPREDILQHLEGCVDFISSAL--AQQGNVLVHCYFGVSRSSSTV
|...   ||     |.  .|..||      .  ....   | ..  .    ... | .. ||...|. . .|| .|.   ....||||.  |||||.. .
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

IAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFR
|.|.|.. .. .  |.||.|  |  ..|| ||. ||. | 
isylmdklkislslalellkdsryiikPnqGflkqleife
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 46-173 3e-15 49.6 In-house 6-134 (145) alignment 
Range on Protein: 46-173
Range on HMM: 6-134/145.0
LFLGNLTAATHMETLRSFKITHILTLDSVP-LPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKR
|. |    | .. ||. . |. |. . .   .  . | .  ...  |   |.   |. ||..   |||     .   |.|||  ||||| .  .|..|| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

HNLDFLPAYELVKAKRRFVQPNAGFVSQL
 |. .  |   |...|    ||  |. .|
cnmtlseaarqvrsnrllaypnvtflknl
0040439 (Phosphotyrosine protein) phosphatases II 49-178 1.4e-22 76.0 In-house 39-243 (249) alignment 
Range on Protein: 49-178
Range on HMM: 39-243/249.0
GNLTA------------------------ATHMETLRSFKITHILTLDSVPLP----------------------------------------QHILEAS
..                           . . . |.  .||.|..| |   .                                        ... . .
sdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydge

FLTTKYIQIADMPREDILQHLEGCVDFISSALA------QQGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQPNAGFVSQL
 .| . ||. |.|  .. ...| ..|||  ..       ..| |||||  ||.|.   ..||.|     |....|.. |..|.. .|. . .| ..  .|
srtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

KLFRR
  . .
yeall
0051429 (Phosphotyrosine protein) phosphatases II 53-176 2.4e-14 49.1 In-house 34-220 (272) alignment 
Range on Protein: 53-176
Range on HMM: 34-220/272.0
AATHMETLRSFKITHILTLDSVPLPQH---ILEASFLTTKYIQIADMPREDILQHL--------------------------------------------
 | . ..|.. .|..|..| |.   ..    ...  ..  .. | |.  ..||..                                             
taadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

----EGCVDFISSALAqQGNVLVHCYFGVSRSSSTVIAYMMKrHNLD--------------FLPAYELVKAKRRFVQPNAGFVSQLKLF
    | ......  |. .|.|||||. |..|.   | ....  ....               ..|.| ..|.|. . .. ... .|  .
gvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
0040438 (Phosphotyrosine protein) phosphatases II 55-178 1.2e-16 56.4 In-house 101-273 (317) alignment 
Range on Protein: 55-178
Range on HMM: 101-273/317.0
THMETLRSFKITHILTLDSVPLP------------------------QHILEASFLTTKYIQIADM----------------PREDILQHLEGCVDFISS
 . . .   ..|.|..| .   .                        . . | .  |   ... |.                |  .. .... ..||.. 
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

ALAQ----QGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRR
. ..    .| |||||  ||.|. . ..||.|     |....|.  |.. ....|. . .. ..  .|  . .
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
0045450 (Phosphotyrosine protein) phosphatases II 56-176 3.1e-19 65.3 In-house 123-299 (307) alignment 
Range on Protein: 56-176
Range on HMM: 123-299/307.0
HMETLRSFKITHILTLDSVPLPQHI-------------------------LEASFLTTKYIQIADM-----------------PREDILQHLEGCVDFIS
. . |.  ..|.|..| .     ..                          . . .|  .. . |.                 |  .. ...| ..||| 
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

SALA------QQGNVLVHCYFGVSRSSSTVIAYMMKRHN--------LDFLPAYELVKAKRRFVQPNAGFVSQLKLF
 ...      ..| |||||  ||.|. . ..||.|.|.         .|.| |..|....|  . .| ..  .|  .
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 57-179 1e-15 53.5 In-house 118-287 (297) alignment 
Range on Protein: 57-179
Range on HMM: 118-287/297.0
METLRSFKITHILTLDSVP----------------------------LPQHILEASFLT-----------TKYIQIADMPREDILQHLEGCVDFISSALA
 . ..  ..|.|..| .                                ...    .               |. . |.   ..|..|   .... .|||
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---QQGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
   ..| |||||  ||.|. . ..||.|     |....|.| |.. .. .|. . .. ..  .|  . ..
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 57-175 1.1e-12 43.5 In-house 105-271 (278) alignment 
Range on Protein: 57-175
Range on HMM: 105-271/278.0
METLRSFKITHILTLDSVPLPQH---------------------------------------ILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALA
 . ..  ..|.|..| .    ..                                         .   .|   ..  ..|  ..  .|.  .||.  .. 
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

----QQGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKL
    ..| |||||  ||.|.   ...|..     |....|.. |.. .. .|    ..  .  .|  
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 81-165 3.2e-11 38.7 In-house 177-270 (288) alignment 
Range on Protein: 81-165
Range on HMM: 177-270/288.0
LEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQ----QGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQP
 .   .| . ..  . |  .. ...| ..||.  .  .    .| |.|||  ||.|.   ......     |.. .|.| |.. .. .| .. .
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvq
0036941 (Phosphotyrosine protein) phosphatases II 84-181 9.8e-17 56.6 In-house 166-277 (297) alignment 
Range on Protein: 84-181
Range on HMM: 166-277/297.0
SFLTTKYIQIADMPREDILQHLEGCVDFISSALA------QQGNVLVHCYFGVSRSSSTVIAYMM--------KRHNLDFLPAYELVKAKRRFVQPNAGF
  .| ..... . |  .. .. . ..|||  ..       ..| |||||  ||.|| . ..|..|        |....|.| |.  .. .| .. .. ..
esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleq

VSQLKLFRRMGC
  .|  .  . .
yrflyeallell
0046845 (Phosphotyrosine protein) phosphatases II 84-162 2.6e-09 32.3 In-house 163-255 (284) alignment 
Range on Protein: 84-162
Range on HMM: 163-255/284.0
SFLTTKYIQIADMPREDILQHLEGCVDFISSALAQ------QGNVLVHCYFGVSRSSSTVIAYMMKRH--------NLDFLPAYELVKAKRRF
  .| ..... . |  .. ...|  ..|.  .  .      .| ..|||  ||.|.   .........        ..|.| |.  .. .| .
esrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0038934 (Phosphotyrosine protein) phosphatases II 85-178 3.5e-15 51.6 In-house 74-174 (194) alignment 
Range on Protein: 85-178
Range on HMM: 74-174/194.0
FLTTKYIQIADM--------PREDILQHLEGCVDFISSAlAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLF
 ..   |.. ..        |  .||..    ||.. ..  ..| |.|||. |..|.   |.||...|....   |..|.. ||. . || .....|  .
efekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr

RR
 .
yk
0050432 (Phosphotyrosine protein) phosphatases II 85-163 5.2e-10 34.6 In-house 196-281 (308) alignment 
Range on Protein: 85-163
Range on HMM: 196-281/308.0
FLTTKYIQIADMPREDILQHLEGCVDFISSALAQ--QGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFV
 .| . ..  . |  .. ...| ..||.  .  .  .|...|||  ||.|.   ......     | ...|.. |.  .. .| ..
srtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
0047943 (Phosphotyrosine protein) phosphatases II 86-172 1.1e-11 40.1 In-house 166-263 (273) alignment 
Range on Protein: 86-172
Range on HMM: 166-263/273.0
LTTKYIQIADMPREDILQHLEGCVDFISSALA------QQGNVLVHCYFGVSRSSSTVIAYMM-----KRHNLDFLPAYELVKAKRRFVQPNAGFVSQ
.| ....  . |  .. ..|| ...||  .        ..| |.|||  ||.|. . ......     |....|.| |. |.. .|  . ..  .  .
rtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf
subfamily_MSG5_pd Subfamily MSG5 88-174 3.1e-16 52.9 In-house 68-154 (165) alignment 
Range on Protein: 88-174
Range on HMM: 68-154/165.0
TKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLK
 ||  |       | . |      | .| ...  .||||  |.|||.| ..||.|| .|| .  ||...|..   ..|. |.. || 
vkyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlm
subfamily_PTPMT1_pd Subfamily PTPMT1 88-179 2.4e-13 44.9 In-house 76-167 (171) alignment 
Range on Protein: 88-179
Range on HMM: 76-167/171.0
TKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDFLPAYELVKAKRRFVQPNAGFVSQLKLFRRM
  .... |.  .  |..||  |.||..   ..  | |||  | .||.. |..|.||...|.   | . .|.||. .. .   ...|. ... 
qlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_Laforin_pd Subfamily Laforin 90-148 8e-06 18.8 In-house 81-139 (183) alignment 
Range on Protein: 90-148
Range on HMM: 81-139/183.0
YIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNLD
.. . |.  |  .. |  .| .. . | .   | |||  || ||.. |  ...   . .
wlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgws
PTPc_DSPc_SM00012 97-149 2.6e-06 22.9 In-house 16-69 (105) alignment 
Range on Protein: 97-149
Range on HMM: 16-69/105.0
PR--EDILQHLEGCVDFISSALAqQGNVLVHCYFGVSRSSSTVIAYMMKRHNLDF
|.  ..||..|. . .. . .   ...|.|||  ||.|.   | .... ... . 
Peesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleke