Gene Mkp3 in Drosophila melanogaster

Synonym: CG14080, CG14081, DMKP-3, Dmel\CG14080, Dmkp3, MKP3, mkp-3, mkp3, Dmel_CG14080, Mkp3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP022_AA protein Get Run
DmelP022_AA_212-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 11-68 7.5e-11 34.5 Pfam-A 2-56 (113) alignment 
Range on Protein: 11-68
Range on HMM: 2-56/113.0
KEWLQSQLrslDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLAST
 ..|...|   ......|||.|  .||...||.||||.. .|.  || .  | .||. 
akelkell...ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaee
subfamily_CDC25_pd Subfamily CDC25 24-57 7.2e-06 17.2 In-house 11-44 (114) alignment 
Range on Protein: 24-57
Range on HMM: 11-44/114.0
KDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRR
......||| ..||.  ||.|||||   . |...
aevliiDcRypyEyegGHikgavnlysreeveee
0043147 (Phosphotyrosine protein) phosphatases II 201-359 9.6e-38 125.0 In-house 5-163 (172) alignment 
Range on Protein: 201-359
Range on HMM: 5-163/172.0
HHHHHHSHHNYNEAPVEIIPGLLFlGNATHSCDSEALKKYNIKYVLNVTPD-LPNKFKESGDIKYLQIPITDHYSQdLAIHFPDAIQFIEE--ARSASSV
..  . |. ...  | ..|...   .. |.. . . ||...|....|.|.  .. .. |  .|.|| .|. ||  . |. .......||.|  |.| . .
sdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

VLVHCLAGVSRSVTVTLAYLMHtRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLR
||||| |||.|..|. .||||. .|||| .|.|.||...| ...|......|. ||..|.|.
vlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
subfamily_DSP6_pd Subfamily DSP6 203-359 6.8e-78 253.6 In-house 2-157 (158) alignment 
Range on Protein: 203-359
Range on HMM: 2-157/158.0
HHHHSHHNYNEAPVEIIPgLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHC
..........|.||||.| ||.||.|......|.|||..||||||||..|||||.|||..|||||||.||.||.|| .||.||.||.||||..| |||||
eedklkkaeaefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhC

LAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLR
|||.||||||||||||... ||||||...|..||...||||.||.|||.||..|||.
laGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
0042113 (Phosphotyrosine protein) phosphatases II 206-355 7.1e-28 93.1 In-house 37-241 (245) alignment 
Range on Protein: 206-355
Range on HMM: 37-241/245.0
HSHHNYNEAPVEIIPGLLFLGNATHSCDSE----ALKKYNIKYVLNVTPDLP--------------------------------------------NKFK
..  | .  ..  |.. ...... .. . |     |....|......|.. .                                             ...
sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdde

ESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARS--ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLL
.  .| |...|. ||   ||  .. |...|...|..  .. .||||| |||.|. |. .||||     ...|.|| .|....|...| . ........| 
srevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly

SFESQ
 .. .
ealle
subfamily_DSP1_pd Subfamily DSP1 208-357 5e-42 137.8 In-house 12-157 (163) alignment 
Range on Protein: 208-357
Range on HMM: 12-157/163.0
HHNYNeaPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVS
.. |.  |||.|   |.|| .|.. . | ||. .|  .|||. .|.| |..    .| .... |. ..|.  .| ..|.||.|....   ||.|| ||.|
lklyd..PvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGis

RSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
|| |. |||||.|. .||..|| .|..|.. .|||. |..|||..|..| 
RsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0036282 (Phosphotyrosine protein) phosphatases II 208-356 2.5e-31 104.1 In-house 4-169 (174) alignment 
Range on Protein: 208-356
Range on HMM: 4-169/174.0
HHNYNEAPVEIIPGLLFLGNATHScDSEALKKYNIKYVLNVTPDLPN-------------KFKESGDIKYLQIPITDHYSQDLAIhFPDAIQFIEEARSA
 .|..   . .|.. |..|.. .. . | ||...|..|.....  ..             .. |  .|.||..|. ||   ||.| . ....|.|||.| 
yinaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse

--SSVVLVHCLAGVSRSVTVTLAYLMHTRGL-SLNDAFAMVRDRK---PDVSPNFHFMQQLLSFESQL
  . .||||| |||.|. |. .||||....| || ||...|| ..   | . ........|  ||..|
dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_MSG5_pd Subfamily MSG5 209-356 3.3e-18 59.3 In-house 20-160 (165) alignment 
Range on Protein: 209-356
Range on HMM: 20-160/165.0
HNYNEAPVEIIPGLLFLGNATHscdSEALKKYNIkyVLNVTPDLPNKFKESGDIKYLQIPITdHYSQdLAIHFPDAIQFIEEARSASSVVLVHCLAGVSR
. | . |. ..|  |.|    .    . |  ...  |.||. ....       .||  |  . | |. ..  ..   . |  |.|    .||||  |.||
rvyldgpllvlpeklylysepk...lkellsfdl..vinvakeindlellvpavkyyhiewe.hdsk.ivkdlsrltriihaatskrkkilvhcqcglsr

SVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
| .. .||.|.  .|||.||. ... .  |.||.. .. ||. .|  |
saslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
subfamily_DSP10_pd Subfamily DSP10 210-357 5.9e-52 169.7 In-house 8-154 (159) alignment 
Range on Protein: 210-357
Range on HMM: 8-154/159.0
NYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRS
....||.  .   ||||... . | .||...||..|||||...||.|.|  ..|| .||..| ..|.|  .| .|..||||||. .| ||||| ||.|||
dietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrs

VTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
.||..||||. ..||||||. .|....| .|||. || ||| || .|.
atvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_STYXL1_pd Subfamily STYXL1 211-356 1.3e-32 106.2 In-house 7-153 (157) alignment 
Range on Protein: 211-356
Range on HMM: 7-153/157.0
YNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGD-IKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRS
... |||..|| |.|||  .... .  |   .| ..||. |  . ..   |  | |.|.. |.   ||  .. .|.||||. .  ..||||    |.|||
lktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrs

VTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
..| .||||. . ..|..|.. ... |..| ||  |..||  .| ||
aaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0046846 (Phosphotyrosine protein) phosphatases II 211-357 1.9e-31 104.6 In-house 8-173 (176) alignment 
Range on Protein: 211-357
Range on HMM: 8-173/176.0
YNEAPVEIIPGLLFLGNA---------THSCDSEALKKYNIKYVLNVTPDL-------PN--KFKESGDIKYLQIPITDHYSQDLaIHFPDAIQFIEEAR
... ...|...|.. .           |.  . | ||...|..|.|.| .        ||  .  |. .|.||..|. ||   ||  .......||.||.
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

SASSVVLVHCLAGVSRSVTVTLAYLMHT-RGLSLNDAFAMVRDRKP-DVSPNFHFMQQLLSFESQLR
..  .||||| ||..|. |. .|||... .|||...|.|.||...|  . ........|  || .|.
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_MKPLT_pd Subfamily MKPLT 211-354 9.6e-30 97.3 In-house 17-158 (164) alignment 
Range on Protein: 211-354
Range on HMM: 17-158/164.0
YNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESgdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSV
..  |  ...  |.|||| |. . . ||. .|....||. .  ..| .|  ..|||. . |   . |. ..  | .|. .|  .   |||||  |.||| 
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||.|.|.. .|  |..|.  ...|.  |.||  |..||  || 
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 211-354 9.6e-30 97.3 In-house 17-158 (164) alignment 
Range on Protein: 211-354
Range on HMM: 17-158/164.0
YNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESgdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSV
..  |  ...  |.|||| |. . . ||. .|....||. .  ..| .|  ..|||. . |   . |. ..  | .|. .|  .   |||||  |.||| 
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||.|.|.. .|  |..|.  ...|.  |.||  |..||  || 
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
0037934 (Phosphotyrosine protein) phosphatases II 211-356 3.6e-27 90.9 In-house 35-241 (243) alignment 
Range on Protein: 211-356
Range on HMM: 35-241/243.0
YNEAPVEIIPGlLFLGNA--------THSCDSEALKKYNIKYVLNVTPDL------------------------------------------PN-KFKES
.|   ... |. |.....        ..  . . |....|......|..                                           .. .  . 
inanliyvtpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltr

GDIKYLQIPITDH---Y-SQDLAIHFPDAIQFIEE-----ARSASSVVLVHCLAGVSRSVTVTLAYLMHTR-GLSLNDAFAMVRDRKPD-VSPNFHFMQQ
 .|.|...|. ||      .||  .. ....||||     |.. ...||||| |||.|. |. .||||... |..| .|....|...|  . ........
lvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrf

LLSFESQL
|  .. .|
lyeallel
0051429 (Phosphotyrosine protein) phosphatases II 212-355 2.2e-22 75.4 In-house 15-223 (272) alignment 
Range on Protein: 212-355
Range on HMM: 15-223/272.0
NeaPVEIIPGLLFLGNAT---HSCDSEALKKYNIKYVLNVTPDL----PNKFKESGDIKYLQIPITDHYSQDLAIHF-----------------------
.    ...||.|.....       | ..||...||........      . ...  .|.||..|| |.. ..  ...                       
y..grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltl

-------------------------PDAIQFIEEARSaSSVVLVHCLAGVSRSVTVTLAYLMHtRGLS--------------LNDAFAMVRDRKPDVSPN
                            ....|. .. .  ||||| ||..|. || ...|.  .|.|              | .| ...|.. | . ..
llsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqt

FHFMQQLLSFESQ
 .....|. .. .
eeqylflyealle
0044763 (Phosphotyrosine protein) phosphatases II 214-358 6.8e-43 141.7 In-house 22-172 (178) alignment 
Range on Protein: 214-358
Range on HMM: 22-172/178.0
APVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDL-------PNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEAR-SASSVVLVHCLAG
 ..||.|| |.||.. ...| | ||...|....|.|..|       . .. |. .|.||.||| ||  .||  ||.....|||||. .  ..||||| ||
naseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPdVSPNFHFMQQLLSFESQLRL
|.|| |. .||||...||||..|...|| |.| ..||.....||. ||..|. 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP19_pd Subfamily DSP19 214-356 5.6e-39 127.9 In-house 10-150 (152) alignment 
Range on Protein: 214-356
Range on HMM: 10-150/152.0
APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVT
  |  .   |.||      |.|.||. .| ..|||. ..|| | .  |..||.|.| |.  .||  ....|..|||||||.  .||||| ||||||..| 
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv

LAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
.||||... |||..|. .||. .| ..||  |..|| ..|..|
iaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 214-354 2.9e-34 111.7 In-house 6-145 (148) alignment 
Range on Protein: 214-354
Range on HMM: 6-145/148.0
APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVT
 | || .. ||||.  .  | ||||. ..  . | | . .| . . | |.||.... |.  .||   |.|.|.|...|...   ||||.  |||||  ..
fpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

LAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
|..|....  ||..|.|.|..... | ||  |..||  .| 
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0041856 (Phosphotyrosine protein) phosphatases II 214-356 4e-33 109.9 In-house 18-172 (182) alignment 
Range on Protein: 214-356
Range on HMM: 18-172/182.0
APVEIIPGlLFLGNATH--------------SCDSEALKKYNIKYVLNVTPDL--PNKFKESGdIKYLQIPITDHYSQDlaihFPDAIQFIEEARSASSV
 . .| .. |.||.  .               .. . ||...|....|.|..|  |....  | |.||..|. ||   |    ......||||... . .
dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlg.iqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKP--DVSPNFHFMQQLLSFESQL
||||| |||.|. |. .||||...|.|| .|...|| |.|   ..||..|. ||. .| .|
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 214-356 7.1e-27 88.1 In-house 119-258 (263) alignment 
Range on Protein: 214-356
Range on HMM: 119-258/263.0
APVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESgdIKYLQI-PITDHYSQDLAIHFPDAIQFIEEARSAsSVVLVHCLAGVSRSVTV
 | |||.. ||||    . .   ||. .. ..|    |.   | .    ||| |  | |    |.  || .   |||| |     ||||| |||||| |.
vPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGrkk.GGvlvhcraGvsrsstl

TLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
...|||. . | ...|. .|  ..| . ||  |..||. .| .|
visylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
PTPc_motif_SM00404 215-354 9.3e-42 137.2 In-house 2-139 (140) alignment 
Range on Protein: 215-354
Range on HMM: 2-139/140.0
PVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKfKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
| .| |. |.||..... ... |||..|..|.|||   ... ||  ....||||. |. ...|. ... ...|||.|..    ||||| ||||||.|...
psrilph.lylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
||||..|.|||..|. .|..|.| .|||..|..||...| 
aYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048179 (Phosphotyrosine protein) phosphatases II 215-356 1.1e-39 130.7 In-house 4-144 (144) alignment 
Range on Protein: 215-356
Range on HMM: 4-144/144.0
PVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
|.||.|| |.||.  ...| | |||..|..|.|.|.. .. | |   |.||..|. ||   ||. .......|||||.. . .||||| |||.|. |. .
pseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
||||...||||..|.|.|| | | . ||......|| .|..|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP8_pd Subfamily DSP8 215-358 4.6e-39 127.5 In-house 15-156 (159) alignment 
Range on Protein: 215-358
Range on HMM: 15-156/159.0
PVEIIPgLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNkFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
| .|..  |.||  ... ..|.|.|..| ||||.    |.  .|  . |.|..|. |.|. .|   |. ...||. |.|... ||||.||| ||| || .
ptrilk.nlylGsqkdvlseellsklgisyvlnasnscpk.leelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRL
||.|.|  .||..|.  |....| .|||. |..||| .| .|.|
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0048076 (Phosphotyrosine protein) phosphatases II 215-356 1.9e-38 126.7 In-house 4-142 (145) alignment 
Range on Protein: 215-356
Range on HMM: 4-142/145.0
PVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
| ||.|| |.||. .. .| | ||...|..|||.|..|.. ...  .|.||..|. ||  .||. .......|||||...  .||||| |||.|. |. .
pseilpg.lylgslptaldlellkdlgittvlnltselellerl..giqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
||||...|.|| .|...|| . | . ||......|. || .|
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
PTEN_1 216-357 1e-33 111.8 In-house 42-192 (196) alignment 
Range on Protein: 216-357
Range on HMM: 42-192/196.0
VeIIPGLLFLGNATHS-CDSEALKKYNIKYVLNVTPDLPN-------KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASS--VVLVHCLAG
   |.. |..|....  .| . ||. .|  |.|.... ..       .. . ....||..||.||  ..|. .|  . .||| ..|...  |||||| ||
q.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaG

VSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
..||.||  ||||....|. ..|...||.. | ..||  ....|| ....|.
lgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
subfamily_STYX_pd Subfamily STYX 216-354 6.1e-21 68.2 In-house 13-155 (166) alignment 
Range on Protein: 216-354
Range on HMM: 13-155/166.0
VEIIPGLlFLGNAT--HSCDSEALKKYNIKYVLNVTPDLPNKFKE---SGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSV
 ||.||| |||  .       | |||  | ... .  ..  ..       ...|| . ..|   ...  ..|   .||... .    ||||  ||.||| 
qeilpgl.flgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.. .||.| | ||   .|||.|..|.  ..||  |..||  .|.
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP15_pd Subfamily DSP15 217-354 1.3e-34 113.5 In-house 4-137 (151) alignment 
Range on Protein: 217-354
Range on HMM: 4-137/151.0
EIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPdlpNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAY
...|| |.||| . | |.| ||. ||  .|.|     |. |   ||.|. |...|  |..|  .| ....|| ..|.    ||||||||||||||.. ||
kvlpg.lylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
||    |. .||. ... ..    ||| | .|| ..| 
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP3_pd Subfamily DSP3 217-357 1.9e-30 99.7 In-house 13-158 (162) alignment 
Range on Protein: 217-357
Range on HMM: 13-158/162.0
EIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPD------LPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSA-SSVVLVHCLAGVSRS
|. |. |..|... . | . |||  | .||| .          ..| .  .|||| ....|  . ||  .|  | .||.|| |  .. ||||| .|||||
evypk.lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

VTVTLAYLMHTRGLSLNDAFAMVRDRKpDVSPNFHFMQQLLSFESQLR
 |. ||||| .| ..|..|   ||... .. ||  |..|| .....|.
atlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
subfamily_DSP12_pd Subfamily DSP12 218-354 5.9e-38 124.7 In-house 5-141 (155) alignment 
Range on Protein: 218-354
Range on HMM: 5-141/155.0
IIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPD-LPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAY
| || |.||....  . | ||...|. || |.   ||.  .. | .....|.|.|. ..|.  |...|..|||||..    ||||| ||||||||. .||
ilpg.lylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
||.. .|||..|. .|.. ||...||  |..||  || 
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP14_pd Subfamily DSP14 219-357 2.7e-37 122.1 In-house 10-145 (157) alignment 
Range on Protein: 219-357
Range on HMM: 10-145/157.0
IPGLLFLGnATHSCDSEALKKYNIKYVLNVTPDLPNkfKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLM
|   |||. .. . . |.|||..|  ..|||..|||  ..  ||.....|..|. ...|| ||  ... |||.. .   .|||| |||||| ...|||||
itpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
... |||..|. .|....| ..||  | .|| ..|..|.
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
0051082 (Phosphotyrosine protein) phosphatases II 219-350 6.9e-27 89.3 In-house 11-147 (151) alignment 
Range on Protein: 219-350
Range on HMM: 11-147/151.0
IPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDL-----PNKFKESGdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSA-SSVVLVHCLAGVSRSVTV
. | |..... .. . | ||...||...|....      |. ..| | |..|.|||.|.  ..| ..|. ...|.|....  . .||||| ||..|. |.
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

TLAYLMHtRGLSLNDAFAMVRDRKP-DVSPNFHFMQQLL
 ..|||. .|.||..|....| . |  | || .|. ||.
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0036941 (Phosphotyrosine protein) phosphatases II 219-356 7.7e-20 66.8 In-house 22-276 (297) alignment 
Range on Protein: 219-356
Range on HMM: 22-276/297.0
IPGLLFLGNATHSCDSEALK----------------------------------------------------------KYNIKYVLNVTPDLPNKFK---
.. ||.||. ....  | |.                                                          ..|.. ....|.. .. ..   
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

-----------E---------------SGDIKYLQIPITD----------------HYSQDLAIHFPDAIQFIEEARS------ASSVVLVHCLAGVSRS
           .               ..|... .. .||                    ..  .. . ..|||..|.       ...||||| |||.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

VTVTLAYLM--------HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
 |. .|.||        ...|... .|. ..|...| . ... ....|  .. .|
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Slingshot_pd Subfamily Slingshot 220-356 1.5e-32 106.3 In-house 23-157 (169) alignment 
Range on Protein: 220-356
Range on HMM: 23-157/169.0
PGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMH
   ..||    ... | ||. ...|.|||| .. | |.|  ...||.| . |. ..||  .. .. .|||.|... | |||||  ||||| .. .|| |.
fdhvylGsewnasnleelkengveyilnvtkeidnffpe..kfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamk

TRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
. ||||..|.. |..|.  . ||  |..||  .|  |
eyglsleealeyvkerrsvikPnkgflkqleeyeGil
0045098 (Phosphotyrosine protein) phosphatases II 220-358 4.4e-29 97.1 In-house 26-273 (278) alignment 
Range on Protein: 220-358
Range on HMM: 26-273/278.0
PGLLFLGNAT-----------------------------------------HSCDSEALKKYNIKYVLNVTPDLPN------------------------
   |.|||.                                          .. . . |....|......|. ...                        
tpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtl

-----------------------KFKESGDIKYLQI-PITDHYSQDLA--IHFPDAIQFIEEARS--------------ASSVVLVHCLAGVSRSVTVTL
                       .  ||  ...|.. |. || . .|    .| ....||.||..               . .||||| |||.|. |. .
lseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

AYLMHTR---GLSLNDAFAMVRDRKPD-VSPNFHFMQQLLSFESQLRL
|||| ..   |..| .|....| ..|  . .|......|  |. .|.|
aylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0049260 (Phosphotyrosine protein) phosphatases II 221-356 2.5e-34 113.5 In-house 13-149 (152) alignment 
Range on Protein: 221-356
Range on HMM: 13-149/152.0
GLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPN-KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEE-ARSASSVVLVHCLAGVSRSVTVTLAYLM
. ...|. |.. . . ||...|......| .|.. |.|.   |.||..|. ||. .||.........|||. |.. . .||||| |||.|. |. .||||
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

HtRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
. .|.|| .|.|.|| ..| . ||......|. ||..|
l.lgvsleeavalvrekRpgavpnpgqlrflyefekll
DSPc Dual specificity phosphatase, catalytic domain 223-354 1.3e-40 133.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 223-354
Range on HMM: 1-132/133.0
LFLGNATHSCdSEALKKYNIKYVLNVTPDLPN-KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTR
|.||.....   . |.|..|..|.|||   || .... ..|.||.||. |. ..... ....|..|||.|..    ||||| ||.||| |...|||| |.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||||.|...|..|.. .|||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 223-354 1.3e-40 133.3 In-house 1-132 (133) alignment 
Range on Protein: 223-354
Range on HMM: 1-132/133.0
LFLGNATHSCdSEALKKYNIKYVLNVTPDLPN-KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTR
|.||.....   . |.|..|..|.|||   || .... ..|.||.||. |. ..... ....|..|||.|..    ||||| ||.||| |...|||| |.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||||.|...|..|.. .|||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer
0049772 (Phosphotyrosine protein) phosphatases II 223-356 1.1e-32 109.4 In-house 155-273 (314) alignment 
Range on Protein: 223-356
Range on HMM: 155-273/314.0
LflgNATHSCDSEALKkynikyvlnvtP-DL-PNKFKESGdIKYLQIPITDhYSQDLAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVT-VTLAYLMH
    |  . .| | ||           .    |..|.. | ||||.||..| .|..|  .|.....||||| .. ..||||| ||..|. | |..||||.
g...neptaadlellk...........eelydpelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk

TRGLSLNDAFAMVRDRKPdVSPNFHFMQQLLSFESQL
 .|.||..|...|| . | ..||..|..||. .| .|
llgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 223-357 2e-25 82.9 In-house 10-153 (154) alignment 
Range on Protein: 223-357
Range on HMM: 10-153/154.0
LFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKES-GD------IKYLQIPITDHYSQDLAIHFPDAIQFIEEAR--SASSVVLVHCLAGVSRSVTVT
|...    . .   |...||| .|||    .| | .   |      |.||.. . |.  .|.  ..  | .||..|      . ||||. .||||| .. 
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

LAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
..|||. . .||  |. ...| .. ..||  |..||  || .|.
isylmdklkislslalellkdsryiikPnqGflkqleifekell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 223-357 1.6e-24 79.6 In-house 6-142 (145) alignment 
Range on Protein: 223-357
Range on HMM: 6-142/145.0
LFLGNATHSCDSEALKKYNIKYVLNVT--PDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHT
|. | | |. |. .|..  |  ..|..    .  .   | .|. | |   |  | ||. || .  .||.  .   . |.|||.|||||||||..|.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
 ...| .|   || ..    || .|...|| .| ||.
cnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0051299 (Phosphotyrosine protein) phosphatases II 224-344 2e-14 49.2 In-house 145-273 (288) alignment 
Range on Protein: 224-344
Range on HMM: 145-273/288.0
FLGNATHSCDSEALKKYNIKYVLNVTPD----LPNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEAR-SASSVVLVHCLAGVSRSVTVTLAYLM
 .|. |  . ||  ... ....| ||.      ... ..   . |...|  ||   | . .. | .... .|. | ...|.||| |||.|. |. ...|.
tygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll

-----HTRGLSLNDAFAMVRDRKPDVSPNFH
     ...|... .|....| ..| . ... 
leqlekeggvdvleavkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 226-343 3.6e-14 48.3 In-house 133-260 (284) alignment 
Range on Protein: 226-343
Range on HMM: 133-260/284.0
GNATHSCDSEALKKYNIKYVLNVTPDL-PNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEARSA---SSVVLVHCLAGVSRSVTVTLAYLMHTR
|. |  . ||  |.. ....| .|.   ... ..   . |...|  ||   . . .. . .....|....   .....||| |||.|. |. ...|....
gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleq

--------GLSLNDAFAMVRDRKPDVSPNF
        |... .|....|...|    ..
lekeglllgvdvleavkrlreqRpgmvqtl
0040439 (Phosphotyrosine protein) phosphatases II 229-357 2.3e-28 94.9 In-house 66-246 (249) alignment 
Range on Protein: 229-357
Range on HMM: 66-246/249.0
THSCDSEALKKYNIKYVLNVTPDLPNKF-----------------------------------------KESGDIKYLQIPITDHYSQDLAIHFPDAIQF
| . . . |....|......|.. ....                                         ... ....|.|..||   ...  .|.|...|
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IEEARS------ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
||..|.       ...||||| |||.|. |. .||||     ...|..| .|....|...| . .|......|. .. .|.
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0050432 (Phosphotyrosine protein) phosphatases II 232-343 7.8e-13 43.9 In-house 172-285 (308) alignment 
Range on Protein: 232-343
Range on HMM: 172-285/308.0
CDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEARsASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLN
. ||  ... ....| .|.   .. ..   . |.  |  ||   . . .. | ...... .  .....||| |||.|. |. ...|.     ...|... 
llseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvf

DAFAMVRDRKPDVSPNF
.|....| ..| . ...
eavkklReqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 234-349 1.5e-15 52.8 In-house 143-264 (273) alignment 
Range on Protein: 234-349
Range on HMM: 143-264/273.0
SEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEARS---ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSL
||  |.. ....| .|.   .. ..   . |. .|  ||   .   .. . |.....|..    ...|.||| |||.|. |. ...|.     ...|...
seetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

NDAFAMVRDRKPDVSPNFHFMQQL
 .|....|...| . ... ....|
leavkllrsqRpgmvqtpeqyrfl
0045450 (Phosphotyrosine protein) phosphatases II 235-356 1.6e-26 89.2 In-house 125-303 (307) alignment 
Range on Protein: 235-356
Range on HMM: 125-303/307.0
EALKKYNIKYVLNVTPDLPNKF--------------------------KESGDIKYLQIPITDH-----------------YSQDLAIHFPDAIQFIEEA
. |...........|.. ....                          .. ..........||.                   ...  .| ....||||.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RS------ASSVVLVHCLAGVSRSVTVTLAYLMHTRG--------LSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
|.       ...||||| |||.|. |. .|||| ...        ..| .|....|...| . .|......|  .. .|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 236-358 1.1e-24 82.8 In-house 120-290 (297) alignment 
Range on Protein: 236-358
Range on HMM: 120-290/297.0
ALKKYNIKYVLNVTPDLPN-----------------------KFKESGDIK-----------------YLQIPITDHYSQDLAIHFPDAIQFIEEARS--
 ............|.  ..                       |... ....                 .. ... ||   ... .. .......||..  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRL
  . .||||| |||.|. |. .||||     ...|... .|....| ..| . ........|  .. .|..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0040438 (Phosphotyrosine protein) phosphatases II 236-359 7e-24 80.1 In-house 105-278 (317) alignment 
Range on Protein: 236-359
Range on HMM: 105-278/317.0
ALKKYNIKYVLNVTPDLPNK-------------------------FKESGDIKYLQIPITDH----------------YSQDLAIHFPDAIQFIEEARSA
 ............|.  ...                         ..| ..|........|.                  ...  .. . ..|.|..|.|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----SSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLR
    ...||||| |||.|. |. .||||     ...|... .|....| ..| . ... ....|  .. .. .|
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_PRL_pd Subfamily PRL 236-338 7.7e-06 20.0 In-house 29-132 (151) alignment 
Range on Protein: 236-338
Range on HMM: 29-132/151.0
ALKKYNIKYVLNVT-PDLPNKFKESGDIKYLQIPITDHYSQDLAIhFPDAIQFIEE--ARSASSVVLVHCLAGVSRS-VTVTLAYLmhTRGLSLNDAFAM
 |||...| |  |  |   ..  |. .|. |...  |  .   ..   . .. ..|  .....|.| |||.||. |. | |.|| .    |.. .||  .
elkkeevktvvrvceptydteklekegievldlafddGavPpeev.veeWlellkekfkeepkstvavhcvaGlGraPvlvalali..eaGmkyedavef

VRDRKPD
.|... .
irekrrg
0043336 (Phosphotyrosine protein) phosphatases II 237-352 1.2e-17 59.8 In-house 108-272 (278) alignment 
Range on Protein: 237-352
Range on HMM: 108-272/278.0
LKKYNIKYVLNVTPDLPN---------------------------------------------KFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEA
....... ....|..  .                                             . ..   . || .|  ||   .   .. | .... ||
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrea

RS-ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSF
..  ...||||| |||.|. |. ..||.     ...|..| .|....| ..|   ... ....|  .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_DSP23_pd Subfamily DSP23 237-338 4e-11 37.8 In-house 27-127 (148) alignment 
Range on Protein: 237-338
Range on HMM: 27-127/148.0
LKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAiHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRK
|    ..|.. .| . . . . . .. . .. | |..   |     . .. .||| . .  | |||| |  |. |.   ||.. |.|.  .| | || ..
lldlgvrylvslteegrphveatpnltlvrlriddyhppale.qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr

PD
| 
pg
subfamily_RNGTT_pd Subfamily RNGTT 237-350 7.9e-07 22.9 In-house 50-168 (189) alignment 
Range on Protein: 237-350
Range on HMM: 50-168/189.0
LKKYNIKYVLNVTPDLPNKFKESG---DIKYLQIPITDHYSQDLAIHFPDAIQFIEE--ARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAM
..|... .|...| . .   ||     .||| .. .. .  .  | .    |. .||  ......|. |||  |  |.  .  .||....  |...| |.
tlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaaval

VRDRKPDVSPNFHFMQQLL
 .  .|    . .....||
FakaRppGiykedylkell
0038934 (Phosphotyrosine protein) phosphatases II 240-357 1.6e-24 82.1 In-house 55-177 (194) alignment 
Range on Protein: 240-357
Range on HMM: 55-177/194.0
YNIKYVLNVT---PDLPNKFKESGDIKYLQIPITDHY---SQDLAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVR
... .|...|   .    .  |. .|.||..|. |..   |...  .| |..... .. ... ||.||| ||..|. |.  |||....|.|...| |..|
vklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

DRKPDVSPNFHFMQQLLSFESQLR
...|.. || .....||.. ..||
ekRpgaipnqdyleallkrykelr
subfamily_PTPMT1_pd Subfamily PTPMT1 240-356 8.4e-18 59.4 In-house 53-168 (171) alignment 
Range on Protein: 240-356
Range on HMM: 53-168/171.0
YNIKYVLNVTPDLPNKFKESgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDV
.|  | |..  .  ...|.  ....||....|.  .    .  ....|||. .|  . | ||| || .|| |.  .|||... ||...|  ....... .
lneeyelkalansteewkkl.gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii

SPNFHFMQQLLSFESQL
  . . ...|  .|..|
rlakkqwkalqeyeekl
subfamily_Laforin_pd Subfamily Laforin 244-337 1e-07 25.0 In-house 60-152 (183) alignment 
Range on Protein: 244-337
Range on HMM: 60-152/183.0
YVLNVtPDLPNK-FKESGdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKP
|  |. |.   | .|| | . |. .|. |  ..     .|.|. ..        .| ||| ||| || ..   .|..  | ||.    ..  ..|
ynenl.pitlkklykeeg.layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp
PTPlike_phytase Inositol hexakisphosphate 254-318 9.8e-07 23.5 Pfam-A 85-147 (149) alignment 
Range on Protein: 254-318
Range on HMM: 85-147/149.0
NKFKESGDIKYLQIPITDHYSQDlAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVTVTLAYLM
....|. ..||  |||||... . . .. . ...|... . .. ....| ||  |. |..  . .
eelaegfgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 254-318 9.8e-07 23.5 In-house 85-147 (149) alignment 
Range on Protein: 254-318
Range on HMM: 85-147/149.0
NKFKESGDIKYLQIPITDHYSQDlAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVTVTLAYLM
....|. ..||  |||||... . . .. . ...|... . .. ....| ||  |. |..  . .
eelaegfgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
subfamily_PTPDC1_pd Subfamily PTPDC1 261-339 4.1e-07 24.6 In-house 82-158 (182) alignment 
Range on Protein: 261-339
Range on HMM: 82-158/182.0
DIKYLQIPITDHYSQDLAiHFPDAIQFIEEARSASsVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDV
.| . .....|. .. |  .  | .. .. | .    | ||| ||  |   .  .||.... |. ..|  .||...|. 
giyvynfgwkDygvasle.riLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpks
subfamily_DSP11_pd Subfamily DSP11 261-333 8.3e-06 19.8 In-house 79-154 (178) alignment 
Range on Protein: 261-333
Range on HMM: 79-154/178.0
DIKYLQIPITDH--YSQDLAIHFPDAIQ-FIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVR
..|||.. .. |   ...|. .| .|.. |.|.     ... |||  || |.  .   ||... |.. .||  .  
gvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafe
subfamily_PTEN_pd Subfamily PTEN 262-326 1.1e-06 23.8 In-house 80-145 (184) alignment 
Range on Protein: 262-326
Range on HMM: 80-145/184.0
IKYLQIPITDHYSQDLAIHFpDAIQFIEE--ARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLN
 .  ..|..|| .  | .   .... ||.  ... . || ||| ||  |. ... |||.... |. .
grvavypfdDhnppplelle.eivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka
PTPc_DSPc_SM00012 283-321 9.6e-07 24.3 In-house 24-65 (105) alignment 
Range on Protein: 283-321
Range on HMM: 24-65/105.0
DAIQFIEEARSA---SSVVLVHCLAGVSRSVTVTLAYLMHTR
.... ... ...   |. |.||| |||.|. |........ .
ellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0048567 (Phosphotyrosine protein) phosphatases II 284-343 3.2e-07 24.9 In-house 63-125 (157) alignment 
Range on Protein: 284-343
Range on HMM: 63-125/157.0
AIQFIEEARSASSVVLVHCLAGV---SRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNF
. .|..  . |. .. ||| ||    .|..|.  .||.   |.. ..|.|..|   |.  |  
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfr