Gene PRL-1 in Drosophila melanogaster

Synonym: BG:DS07473.3, BcDNA:RE40268, CG4993, Dmel\CG4993, PRL, PRL1, PrL-1, dPRL-1, Dmel_CG4993, PRL-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP023_AA protein Get Run
DmelP023_AA_17-164 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 14-162 1.4e-76 249.7 In-house 2-150 (151) alignment 
Range on Protein: 14-162
Range on HMM: 2-150/151.0
PALIEYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGL
.. |||| |.|||||||.| |....|.||||..|.||||||||.|.|..||..||.|.||||.||. ||..||.||.|.||.|....|...|||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPKAR
||||||||||||| |.||| |||.||.|||||||.|||.||||||.|..
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0041856 (Phosphotyrosine protein) phosphatases II 18-167 1.1e-28 95.5 In-house 30-175 (182) alignment 
Range on Protein: 18-167
Range on HMM: 30-175/182.0
EYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPqqvVDEWFEVLKDKYQqnPEACVAVHCVAGLGRAP
 .....|..| .| . |.....  ||.....|.|...|. |. ..|| .||....| ..|.. |.   .||... ... ..  .. .|.||| ||.||..
slpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtg

VLVALALIE-LGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPKARLKHKN
.|||. |.. ||. .| ||...| .| |..   .  |.. ..   .|..|.
tlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0043147 (Phosphotyrosine protein) phosphatases II 19-159 3.1e-35 116.8 In-house 17-158 (172) alignment 
Range on Protein: 19-159
Range on HMM: 17-158/172.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPV
|. ..|..|  | . |.....  ||.......|...|  |... || .||..  | ..|.. |. ....|..| ........|. .|.|||.||.||...
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgt

LVALALIELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKYKP
|||. |..|||..| ||...|.||.||. |  |. || ..  
lvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfek
0045098 (Phosphotyrosine protein) phosphatases II 19-163 1.7e-28 95.3 In-house 61-273 (278) alignment 
Range on Protein: 19-163
Range on HMM: 61-273/278.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNT----------------------------------------------DELETQGITVKD
. ..||..|. | . |.....  |........|...|  ...                                               .||. |.|. .
gypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

L-AFEDGTFPPQQVVDEWFEVLKDKYQ---------------QNPEACVAVHCVAGLGRAPVLVALALIEL----GLKYEAAVEMIRDKRRG-AI-NAKQ
.  ..|.. |.. ... ..|.|.   .               .... .|.||| ||.||. .|||. |.      |. .. ||...| .|.| |. |  |
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

LSFLEKYKPKARL
. ||...  . .|
yrflyefllelll
0045450 (Phosphotyrosine protein) phosphatases II 19-157 5.1e-27 90.8 In-house 104-299 (307) alignment 
Range on Protein: 19-157
Range on HMM: 104-299/307.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDE------------------------------------------LETQGITVKDLAF-
....||..|. | . |.....  |....|...|...|. ....|                                           . ...||. . . 
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

--EDGTFPPQ-QVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALIELG---------LKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
   |.. ||  . . ...| ... .... .. .|.||| ||.||.....|. |.  .         . .. ||...|..| ||. |  |. || ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 19-157 9e-27 89.7 In-house 51-241 (249) alignment 
Range on Protein: 19-157
Range on HMM: 51-241/249.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPS---------------------------------------------YNTDELETQGITVKDL
| ...|..|. | . |.....  |........|.....                                              |. .... ..| . |.
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdw

AfEDGTFPPQQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
  ..|. |  . .....| ... .... .. .|.||| ||.||.....|. |.      |||. .| ||...|..|.||. |  |. || ..
p.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 19-158 3.8e-22 74.8 In-house 83-270 (314) alignment 
Range on Protein: 19-158
Range on HMM: 83-270/314.0
YkgMKFLITDRPSDITINHY------------IMELKKNNVNTVVR---------------------VC------------------EPSYNTDELETQG
.  .||..|  |..||.. .            ...  ..|| ..|                       .                  |  |. . .| .|
f..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellkeelydpelferlg

ITVKDLAFEDGTFPPQQVVDEWFEVLKDKyqqNPEACVAVHCVAGLGRAP--VLVALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYK
|..... ..||..|. . .||..|....    ... .|.||| || ||..  |..|. .. ||. .| |.|..| ||   .|  .. .|| | 
ikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqye
0050432 (Phosphotyrosine protein) phosphatases II 19-149 4.4e-21 70.9 In-house 105-285 (308) alignment 
Range on Protein: 19-149
Range on HMM: 105-285/308.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNT--------------DELETQGITVKDLAF-----------------------------
.. .||..|  | . |.....  . ..||...|..... .|               . ||  ..||. |                               
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

---EDGTFPPQ-QVVDEWFEVLKDKYqqnPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAINAK
   .|.  ||. . . ...| .....   |.  ..||| ||.||. ...|| |.      | |. .. || ..| .| |... .
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 19-148 4e-18 61.3 In-house 74-259 (284) alignment 
Range on Protein: 19-148
Range on HMM: 74-259/284.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNT---------------------------------------------DELETQGITVKDL
|. .||..|  | . |....   . ..||...| ..|.  |                                              .. . . .    .
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyt

AFEDGTFPP-QQVVDEWFEVLKDKYQQ-NPEACVAVHCVAGLGRAPVLVALALIELGLKYEA---------AVEMIRDKRRGAINA
.. |   ||  . . |... ... ... ...  ..||| ||.||. ...|| |.   |..|          || ..|..| |... 
swpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0049260 (Phosphotyrosine protein) phosphatases II 20-157 3.1e-33 110.0 In-house 7-145 (152) alignment 
Range on Protein: 20-157
Range on HMM: 7-145/152.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVL
....|..|  | . |.....  ||.....|.|...|..... . . |.|... | ..|.. |.   . ...  . .|...... .|.|||.||.||...|
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VALALIELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
||. |..||...| ||...| || ||. |  || || ..
vaaylmllgvsleeavalvrekRpgavpnpgqlrflyef
0046846 (Phosphotyrosine protein) phosphatases II 20-158 1.5e-29 98.4 In-house 21-169 (176) alignment 
Range on Protein: 20-158
Range on HMM: 21-169/176.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEP--------SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeACVAVHCVA
 | ....|. |   |. ... .||......||...|.         .  .|||. ||... | ..|.. |. . ..|..| ... ....   .|.|||.|
lgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsa

GLGRAPVLVALALIEL--GLKYEAAVEMIRDKRR-GAI-NAKQLSFLEKYK
|.||...|||. |.||  ||..| |....|..|. ||. . .|. ||... 
GigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe
0040438 (Phosphotyrosine protein) phosphatases II 20-157 3.5e-25 84.4 In-house 84-271 (317) alignment 
Range on Protein: 20-157
Range on HMM: 84-271/317.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN------------------------TDELETQGITVKDLAF-------------------E
...||..|  | . |.....  .....|...|...|. ..                        ..| | .|||.  | .                    
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

DGTFPP-QQVVDEWFEVLKDKYQqNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
|...||  . . ...| ...... .|. .|.|||.||.||. ...|. |.      | |. .| ||...| .|.||. .  |. || ..
dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0047943 (Phosphotyrosine protein) phosphatases II 20-153 2.4e-21 71.9 In-house 75-263 (273) alignment 
Range on Protein: 20-153
Range on HMM: 75-263/273.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTD--------------ELETQGITVKD--------------------------------L
...||..|. | . |.....  ....||...|...|. ..                .|.   .||.                                 .
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhyt

AFEDGTFP-PQQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSF
 . |   |   . . |..|.........  .  |.|||.||.||. ...|| |.      | |. .. || ..|..| |.. .  |. |
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf
0051299 (Phosphotyrosine protein) phosphatases II 20-149 4.5e-19 64.4 In-house 90-272 (288) alignment 
Range on Protein: 20-149
Range on HMM: 90-272/288.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPS------------------------YNTDELETQGITVKDLAFE-------------------
...||..|  | . |....   . ..||...|.....                         ....| . ...||  |  .                   
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

----DGTFPP-QQVVDEWFEVLKDKYQqNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAINAK
    |  .|.  . . .. . ...... ... .|.||| ||.||. ...|| |.      | |. .. ||...| .| |...  
tnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 20-153 1.8e-18 62.3 In-house 76-268 (297) alignment 
Range on Protein: 20-153
Range on HMM: 76-268/297.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN-------------TDELETQGITVKDLAFED-----------------------------
 ..||..|  | . |....   . ..||...| ..|.  .              ..|.  ..||. | .|                              
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhy

-----GTFPP-QQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALAL---------IELGLKYEAAVEMIRDKRRGAINAK-QLSF
        |.  . . ...| .......  ..  | |||.||.||. ...|. |         .| |. .  || ..|..| ||.    |. |
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf
0042113 (Phosphotyrosine protein) phosphatases II 21-157 6.3e-28 93.2 In-house 51-238 (245) alignment 
Range on Protein: 21-157
Range on HMM: 51-238/245.0
GMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN-------------------------------------------TDELETQGITVKDLAFED
  ||..|. |.. |.....  |......|.|...|. ..                                            |  . ..|..  | ..|
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

GTFPP-QQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
.. |.  . .....| ... ......  |.||| ||.||. ...|. |.      |||.  | ||...|..|.||. .  |. || ..
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0036282 (Phosphotyrosine protein) phosphatases II 21-157 2.5e-27 91.1 In-house 16-165 (174) alignment 
Range on Protein: 21-157
Range on HMM: 16-165/174.0
GMKFLITDRPSDitinhYIMELKKNNVNTVVRVCEPSYNT------------DELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVH
  ...... | .     .. .||.....|||...|. ..             . ||  ||....| ..|.. |. ....|... ... ....|. .|.||
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CVAGLGRAPVLVALALIELGL--KYEAAVEMIRDKR----RGAINAKQLSFLEKY
| ||.||...|||. |.. ||  ... |....| .|    .. ..  |. || ..
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0039614 (Phosphotyrosine protein) phosphatases II 21-160 1.2e-26 89.4 In-house 100-287 (297) alignment 
Range on Protein: 21-160
Range on HMM: 100-287/297.0
GMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN----------------------TDELETQGITVKDL-----------------AFEDGTFP
..||..|  |.. |.....  .....|...|..... ..                      ... . .|.||  |                  . |.. |
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvp

P-QQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKYKPK
|  ....|..| ... .... .. .|.|||.||.||. ...|. |.      | |. .. ||...| .|.||. .  |. || ..  .
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 21-155 9e-24 79.8 In-house 87-270 (278) alignment 
Range on Protein: 21-155
Range on HMM: 87-270/278.0
GMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN------------------------------------------TDELETQGITVKDLAFEDG
..||..|  |.. |.....  .....|.|.|...|. ..                                           |  . ..  .  |.. |.
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

TFP-PQQVVDEWFEVLKDKYQqNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLE
..| . . . .. ........ ... .|.|||.||.||. ...|| |.      |.|. .| ||...| .| ||. .  |. || 
gvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
0038934 (Phosphotyrosine protein) phosphatases II 23-156 3.2e-35 116.9 In-house 19-171 (194) alignment 
Range on Protein: 23-156
Range on HMM: 19-171/194.0
KFLITDRPSDITINHYIMELKKNNVNTVVRVC----------------EPSYNTDELETQGITVKDLAFED-GTFPPQQVVDEWFEVLKDKYQQNPEACV
.|.....|.. ....|| ||........||..                |. |...|.|  ||.. .| |.| || |...................|. .|
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAIN-AKQLSFLEK
||||.|||||...||| .||. ||...|.|....|.||.|||.  ..|. | |
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk
0037934 (Phosphotyrosine protein) phosphatases II 23-157 1e-25 86.1 In-house 45-237 (243) alignment 
Range on Protein: 23-157
Range on HMM: 45-237/243.0
KFLITDRPSDITINH----YIMELKKNNVNTVVRVCEPS------------------------------------------YNTDELETQGITVKDLAFE
.. .|. | . |...    ..  |........| ..|.                                           ...|.|. ..| .  |.. 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGTFPP-QQVVDEWFEVLKDKYQQ-------NPEACVAVHCVAGLGRAPVLVALALIEL--GLKYEAAVEMIRDKRRG-AI-NAKQLSFLEKY
|.. |.  . . .... ... ...       ...  |.|||.||.||. .|.|. |. |  |. .| ||...|..| | |. .  |. || ..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0051429 (Phosphotyrosine protein) phosphatases II 23-157 3.2e-19 65.1 In-house 23-220 (272) alignment 
Range on Protein: 23-157
Range on HMM: 23-220/272.0
KFLITDRPSDITINHYIMElKKNNVNTVVRVCEPS---YNTDELETQGITVKDLAFEDGTFPPQ------------------------------------
... ...|...|....    |.....|.| .....   ..  ... .||..  | ..| ..|.                                     
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------QVVDEWFEVLKDkyqqnpEACVAVHCVAGLGRAPVLVALALIELGLK--------------YEAAVEMIRDKRRGAI-NAKQLS
                . . |..|.| |      .  | ||| || .|  ..||| |. ||.               .|.|||..|..|.||. .  |. 
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

FLEKY
|| ..
flyea
0044763 (Phosphotyrosine protein) phosphatases II 24-160 2.6e-26 87.8 In-house 30-169 (178) alignment 
Range on Protein: 24-160
Range on HMM: 30-169/178.0
FLITDRPSditiNHYIMELKKNNVNTVVRVCEPSY------NTDELETQGITVKDLAFEDGTFPP-QQVVDEWFEVLKDKYQQNPeACVAVHCVAGLGRA
..... |.     ...  ||.......|...|. .      .   .|  ||... . ..|.. |.  . ..|..| ... .....  .|.||| ||.||.
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRs

PVLVALALI-ELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPK
..|||. |. .||| .|.|.|..| .|.. .|  || .|... ..
gtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelr
0051082 (Phosphotyrosine protein) phosphatases II 24-154 4e-24 80.3 In-house 15-144 (151) alignment 
Range on Protein: 24-154
Range on HMM: 15-144/151.0
FLITDRPSDitinHYIMELKKNNVNTVVRVCEPS---YNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLV
..... |..    ... .||.....|.| ....    |... |. .||.|... ..| ..|. ..  ...  . ........ .|.||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALALIELGLKYEAAVEMIRDKRRGAINAKQLSFL
|| |. ||. .|.|.|..| || |... .|  ..
alylmllgvsleealeeyrlkrpgvvqpnqqflf
0048179 (Phosphotyrosine protein) phosphatases II 36-158 2.9e-22 74.4 In-house 19-141 (144) alignment 
Range on Protein: 36-158
Range on HMM: 19-141/144.0
NHYIMELKKNNVNTVVRVCEPsYNTDELETQGITVKDLAFEDGTFPPQ-QVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALI-ELGLKYEA
 . . .|||....||....|. |  ..|| .||..  | ..|   |.  . ..|..| ... ....   .|.||| ||.||...|||. |. .||| .| 
aldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglslee

AVEMIRDKRRGAI-NAKQLSFLEKYK
|....| .| ||. |  || ||..| 
alalvrsrrpgavpnpgqlrfLleye
subfamily_CDC14_pd Subfamily CDC14 36-157 8.6e-22 72.4 In-house 202-319 (328) alignment 
Range on Protein: 36-157
Range on HMM: 202-319/328.0
NHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKyqqnpEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAA
....   .||||.||||. .  |.  . . .|.  ||| |.||. |....| .. |....      |  .|||| |||||.  |.|  |. . ..  . |
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VEMIRDKRRGAINAKQLSFLEKY
.  .|  | | . ..| .|||. 
iawlricrPGsvigpqqkfleek
subfamily_PTPMT1_pd Subfamily PTPMT1 36-159 4.5e-10 34.2 In-house 35-166 (171) alignment 
Range on Protein: 36-159
Range on HMM: 35-166/171.0
NHYIMEL-KKNNVNTVVRVCEPSY------NTDELETQGITVKDLAFEDGT-FPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALI-E
...| || .|.||..|| ..|         .|.| . .|..   ||  | |  | .. . .  |....   ..   .| ||| || ||.  |||  |. .
rslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkk

LGLKYEAAVEMIRDKRRG-AINAKQLSFLEKYKP
  |. | |......||.   .. ||.. |..|. 
eklspeeAlkalkkkRkiirlakkqwkalqeyee
PTEN_1 37-157 7.5e-24 79.6 In-house 58-188 (196) alignment 
Range on Protein: 37-157
Range on HMM: 58-188/196.0
HYIMELKKNNVNTVVRVCE------PSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNP-EACVAVHCVAGLGRAPVLVALALIELG-
 .  .||.... .||...|      .||. .| . .|...... .|| . |. . . .. ..... ....| . .|.||| |||||  ..||  |...| 
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

LKYEAAVEMIRDKR-RGAIN-AKQLSFLEKY
| .. |.|..|.|| .||.| ..|  .|| .
ltadeAlelvrekRppgapnspsqerlleyf
0048076 (Phosphotyrosine protein) phosphatases II 37-158 6.3e-21 70.0 In-house 20-139 (145) alignment 
Range on Protein: 37-158
Range on HMM: 20-139/145.0
HYIMELKKNNVNTVVRVcepSYNTDELETQGITVKDLAFEDGTFPPQ-QVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALIEL-GLKYEAA
. . .||.... ||...   ..... || .||..  | ..| . |.  . ..|..| ... ....   .|.||| ||.||...|||. |. | |. .| |
ldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleea

VEMIRDKRRGAI-NAKQLSFLEKYK
.|..| .|.||. |  || ||... 
lelvrsqrpgavpnpgqlrflyefe
subfamily_PTEN_pd Subfamily PTEN 39-133 5.1e-09 31.4 In-house 54-145 (184) alignment 
Range on Protein: 39-133
Range on HMM: 54-145/184.0
IMELKKNNVNTVVRVCEPSYNTDELETQgitVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEA
. . .|....      | .|........   |. . |.| . || ....|  | ...  .....  |.||| || ||. ||..  |.. .|  .|
lekkhkdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka
subfamily_DSP19_pd Subfamily DSP19 39-145 4e-08 27.7 In-house 30-133 (152) alignment 
Range on Protein: 39-145
Range on HMM: 30-133/152.0
IMELKKNNVNTVVRVCEPSYN--TDELETQGITVKDLAFEDGTfppqQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAP-VLVALALIELGLKYEAAV
  .||....  .. |     |  ....... | . ||  .| .    .. .| .. ...  ...   .| ||| ||  |.. | .|  . .  |..| |.
keilkekkitHilnvatgvpnvfpkdftylsieilDlpetdll....sylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeelsleeal

EMIRDKRRGA
|..|..|. .
elvrearpci
subfamily_RNGTT_pd Subfamily RNGTT 40-150 3.8e-12 40.3 In-house 48-162 (189) alignment 
Range on Protein: 40-150
Range on HMM: 48-162/189.0
MELKKNNVNTVVRVC--EPSYNTDELETQGITVKDLAFE-DGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAV
....|...  |. .   .. |...|||..||. . |. .  |  | .. |.|. ..... ...|||  ..|||  |  |.  |..  |.|    . ||||
lktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaav

EMIRDKRRGAINAKQ
.. .  |   |  ..
alFakaRppGiyked
subfamily_DSP12_pd Subfamily DSP12 40-153 5.1e-07 24.2 In-house 21-135 (155) alignment 
Range on Protein: 40-153
Range on HMM: 21-135/155.0
MELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGT-FPPQQVVDEWFEVLKDKYqqNPEACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEM
  ||. ... |. | . . .. .|... .. | .   |    .  .  || .. ...    . |  | ||| ||. |   . .|  . . .|. | |...
ellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlkl

IRDKRRGA-INAKQLSF
...|.. .  |.  |. 
vkekkpeiepNegFleQ
subfamily_Slingshot_pd Subfamily Slingshot 40-155 1.9e-06 21.4 In-house 38-151 (169) alignment 
Range on Protein: 40-155
Range on HMM: 38-151/169.0
MELKKNNVNTVVRVCE--PSYNTDELETQGITVKDLAFEDgtFppQQVVDEWFEVLKDKYQQnpEACVAVHCVAGLGR-APVLVALALIELGLKYEAAVE
 |||.|.|. .. | .   ..  ...| . | | |   .|  .   .  .| .. ..   ..  .. | |||  |. | | ...| |. | ||..| |.|
eelkengveyilnvtkeidnffpekfeylnirvydeeetd..l..lkywnetykfiekakkk..gskvlvhckmGvsrsastviayamkeyglsleeale

MIRDKRRGAI-NAKQLSFLE
 ....|. .  |.  |. ||
yvkerrsvikPnkgflkqle
PTPc_motif_SM00404 41-155 2.6e-10 35.3 In-house 22-132 (140) alignment 
Range on Protein: 41-155
Range on HMM: 22-132/140.0
ELKKNNVNTVVRVCEPSYNTdeLETQGITVKDLAFED-GTFPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAAVEMI
 |||... .|. | |   .|   |..|.... .  .| .. . ..  |.  .....   .. .  | ||| ||. |   |..  |. . .|....|.|..
llkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefv

RDKRrgAINAKQLSFLE
...|   |  ..|.|..
kerR..piispnlnfvr
DSPc Dual specificity phosphatase, catalytic domain 41-148 2.3e-09 32.2 Pfam-A 13-119 (133) alignment 
Range on Protein: 41-148
Range on HMM: 13-119/133.0
ELKKNNVNTVVRVCEPS-----YNTDELETQGITVKDlafeDGTFPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAA
 |.|.... |. | .       ... | |  .| |.|    . .   ..  .|  |....   .. .  |.||| ||. | . |..  |..  .|... |
lleklgitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA

VEMIRDKRrGAINA
.|.....| ..|. 
yefvkerr.skisp
DSPc Dual specificity phosphatase, catalytic domain 41-148 2.3e-09 32.2 In-house 13-119 (133) alignment 
Range on Protein: 41-148
Range on HMM: 13-119/133.0
ELKKNNVNTVVRVCEPS-----YNTDELETQGITVKDlafeDGTFPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAA
 |.|.... |. | .       ... | |  .| |.|    . .   ..  .|  |....   .. .  |.||| ||. | . |..  |..  .|... |
lleklgitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA

VEMIRDKRrGAINA
.|.....| ..|. 
yefvkerr.skisp
subfamily_DSP15_pd Subfamily DSP15 41-157 2.8e-08 28.0 In-house 22-135 (151) alignment 
Range on Protein: 41-157
Range on HMM: 22-135/151.0
ELKKNNVNTVVRVCEpsyNTDELETQgITVKDLAFEDGtfpPQQVVDEWFEVLKDKY--QQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEM
 ||..|. ... | .   |. .|  . |. | .| .|    |.. ....|.   .     .  |  | |||.||. |.  ||.. |.  . |... |.|.
lLkeknithilsvhd...nakkllkd.ieYkciaasDt...psaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalev

IRDKRRGAI-NAKQLSFLEKY
|. .|  |  |.   . |..|
ikaaRsvanPnfGfkrqlkey
0048567 (Phosphotyrosine protein) phosphatases II 42-156 5.6e-10 33.8 In-house 12-132 (157) alignment 
Range on Protein: 42-156
Range on HMM: 12-132/157.0
LKKNNVNTVVRVCEPSYNTDEL-ETQGITVKDLAFEDGtFPPQQVVDEWFEVLKDKYQ--QNPEACVAVHCVAGL---GRAPVLVAL-ALIELGLKYEAA
 .. ......|. .  ||.  .  ..|.   |. |..|  ..  .. ... .|.....  .. .  .|||| |||   ||. .|... ... ||.  | |
pdrlyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeea

VEMIRDKRRGAINAKQLSFLEK
....|  | | .   . |.|. 
iaplrivrpgsvpfrdasylls
subfamily_DSP10_pd Subfamily DSP10 42-155 2.3e-06 21.6 In-house 35-144 (159) alignment 
Range on Protein: 42-155
Range on HMM: 35-144/159.0
LKKNNVNTVVRVCEPSYNT---DELETQGITVKDLAFEDgtfpPQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEM
|.. |...|. |   . |.   ..|. . | |.|   ..     .|  .| .| ...  ...  . | ||| ||. |.  | .|  . .|.|. . | ..
ldrlnitavlnvttsvPnefeeealkYkripvsDtskqn....lkqyfeealefieearkkg..srvLvhCqaGisrsatvviaYlmkhlnlslndaykf

IRDKRrgAINAKQLSFLE
...||  .| .  |.|. 
vkekr..piisPnLnfmG
subfamily_DSP8_pd Subfamily DSP8 44-156 3.7e-06 20.6 In-house 38-146 (159) alignment 
Range on Protein: 44-156
Range on HMM: 38-146/159.0
KNNVNTVVRVCEPSYNTDELETQG---ITVKDLAFEDgTFPpqqVVDEWFEVLkDKYQQNpEACVAVHCVAGLGRAP-VLVALALIELGLKYEAAVEMIR
|.... |. . .   ...||. .    . |||   |.   |   . |. .| . || ... ...| ||. ||  |.. | .|  . .| .... | . ..
klgisyvlnasnscpkleelkeskflrvPvkDkydek.llp...wfdksvefi.dkakse.ngrvlvhvlaGisrsatvaiayimktlemsldeayrfvk

DKRrGAINaKQLSFLEK
.||  .|. ..| ||..
ekr.ptis.pnlnflgq
subfamily_PTPDC1_pd Subfamily PTPDC1 57-157 1e-13 46.1 In-house 72-171 (182) alignment 
Range on Protein: 57-157
Range on HMM: 72-171/182.0
SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeaCVAVHCVAGLGRAPVLVALALI-ELGLKYEAAVEMIRDKRRGAINAK-QLSFL
||....|  |||.|  ....|   .. . . .   |..   |..    ||||| |||||. ||.|  |.    |. | |....|.||  .|... |. ..
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

EKY
...
kef
subfamily_DSP11_pd Subfamily DSP11 57-146 1.2e-08 29.0 In-house 69-161 (178) alignment 
Range on Protein: 57-146
Range on HMM: 69-161/178.0
SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKY--QQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAI
 |...||. .|.. . |     ..| ...|... |..|.    ... .. ..|||  |. |.  |.   ||.  |.. | |.|.  . |  ..
yykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsl
subfamily_DSP3_pd Subfamily DSP3 57-158 2.8e-06 21.1 In-house 57-154 (162) alignment 
Range on Protein: 57-158
Range on HMM: 57-154/162.0
SYNTDELETQGITVKDLAFEDgtfpPQQVVDEWFEVLKDKYQQnPEACVAVHCVAGLGRAPVLV-ALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLE
 |.  |..  |. |.|    |     ..  .. .. ...  .| .|. | ||||.|. |...|| |  .|   ..   |.. .|.||.   |   |  | 
fykdleikylGlevdDvpefd....lskyFetaakfidealsq.kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLa

KYK
...
eld
subfamily_CDKN3_pd Subfamily CDKN3 61-160 3.1e-08 27.4 In-house 93-194 (202) alignment 
Range on Protein: 61-160
Range on HMM: 93-194/202.0
DELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALIEL--GLKYEAAVEMIRDKR-RGAIN-AKQLSFLEK
|. .. |..|.   . ||. |      . .| |.   ..       |||  ||||. ...|  |. |   .... |.. .|| .  .||.  ||  .|..
dlyqqaglivhhypiadglvpdiasclkileelrinlkay..rktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylse

YKPK
.. |
frdk
subfamily_DSP23_pd Subfamily DSP23 62-148 9.5e-10 33.3 In-house 47-131 (148) alignment 
Range on Protein: 62-148
Range on HMM: 47-131/148.0
ElETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpEAcVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAINA
|  | ..|.. |  .| . |  . |.|. .|...  ..| || |.|||. | ||.  ..|  |.   .|    |.  .| .| |....
e.atpnltlvrlriddyhppaleqvvefvrvveeaeekn.ea.vsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet
PTPc_DSPc_SM00012 84-149 6.2e-09 31.4 In-house 20-93 (105) alignment 
Range on Protein: 84-149
Range on HMM: 20-93/105.0
QVVDEWFEVLKDKYQQNP-EACVAVHCVAGLGRAPVLVALALIELGLKYEA-------AVEMIRDKRRGAINAK
. . |... .|......  .. | ||| || ||. ..|||...   |..|         |...|..|.|... .
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 88-138 1.4e-06 22.7 In-house 203-259 (297) alignment 
Range on Protein: 88-138
Range on HMM: 203-259/297.0
EWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVE------MI
.. . ......|| |. . |||.||.||. ||...  .    | | .|.      ..
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkkl
Y_phosphatase Protein-tyrosine phosphatase 90-154 1.7e-07 26.3 Pfam-A 156-229 (235) alignment 
Range on Protein: 90-154
Range on HMM: 156-229/235.0
FEVLKDKYQ--QNPEACVAVHCVAGLGRAPVLVALALIELGLKY------EAAVEMIRDKRRGAINA-KQLSFL
......  .  .. .. | ||| || ||. ..||| ..   |.         .|...| .|.|...  .|. ||
ldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 90-154 1.7e-07 26.3 In-house 156-229 (235) alignment 
Range on Protein: 90-154
Range on HMM: 156-229/235.0
FEVLKDKYQ--QNPEACVAVHCVAGLGRAPVLVALALIELGLKY------EAAVEMIRDKRRGAINA-KQLSFL
......  .  .. .. | ||| || ||. ..||| ..   |.         .|...| .|.|...  .|. ||
ldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
subfamily_Ptp69D_pd Subfamily Ptp69D 90-138 8.7e-06 20.1 In-house 208-255 (307) alignment 
Range on Protein: 90-138
Range on HMM: 208-255/307.0
FEVLKDKYQQNpEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMI
 | ... |..| .. . ||| || ||. ..|||...   || |  |...
ieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif