Gene PRL-1 in Drosophila melanogaster

Synonym: BG:DS07473.3, BcDNA:RE40268, CG4993, Dmel\CG4993, PRL, PRL1, PrL-1, dPRL-1, Dmel_CG4993, PRL-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP023_AA protein Get Run
DmelP023_AA_17-164 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 14-162 1.4e-76 249.7 In-house 2-150 (151) alignment
Range on Protein: 14-162
Range on HMM: 2-150/151.0
PALIEYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGL
.. |||| |.|||||||.| |....|.||||..|.||||||||.|.|..||..||.|.||||.||. ||..||.||.|.||.|....|...|||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPKAR
||||||||||||| |.||| |||.||.|||||||.|||.||||||.|..
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk

0041856 (Phosphotyrosine protein) phosphatases II 18-167 1.1e-28 95.5 In-house 30-175 (182) alignment
Range on Protein: 18-167
Range on HMM: 30-175/182.0
EYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPqqvVDEWFEVLKDKYQqnPEACVAVHCVAGLGRAP
 .....|..| .| . |.....  ||.....|.|...|. |. ..|| .||....| ..|.. |.   .||... ... ..  .. .|.||| ||.||..
slpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtg

VLVALALIE-LGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPKARLKHKN
.|||. |.. ||. .| ||...| .| |..   .  |.. ..   .|..|.
tlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

0043147 (Phosphotyrosine protein) phosphatases II 19-159 3.1e-35 116.8 In-house 17-158 (172) alignment
Range on Protein: 19-159
Range on HMM: 17-158/172.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPV
|. ..|..|  | . |.....  ||.......|...|  |... || .||..  | ..|.. |. ....|..| ........|. .|.|||.||.||...
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgt

LVALALIELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKYKP
|||. |..|||..| ||...|.||.||. |  |. || ..  
lvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfek

0045098 (Phosphotyrosine protein) phosphatases II 19-163 1.7e-28 95.3 In-house 61-273 (278) alignment
Range on Protein: 19-163
Range on HMM: 61-273/278.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNT----------------------------------------------DELETQGITVKD
. ..||..|. | . |.....  |........|...|  ...                                               .||. |.|. .
gypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

L-AFEDGTFPPQQVVDEWFEVLKDKYQ---------------QNPEACVAVHCVAGLGRAPVLVALALIEL----GLKYEAAVEMIRDKRRG-AI-NAKQ
.  ..|.. |.. ... ..|.|.   .               .... .|.||| ||.||. .|||. |.      |. .. ||...| .|.| |. |  |
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

LSFLEKYKPKARL
. ||...  . .|
yrflyefllelll

0045450 (Phosphotyrosine protein) phosphatases II 19-157 5.1e-27 90.8 In-house 104-299 (307) alignment
Range on Protein: 19-157
Range on HMM: 104-299/307.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDE------------------------------------------LETQGITVKDLAF-
....||..|. | . |.....  |....|...|...|. ....|                                           . ...||. . . 
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

--EDGTFPPQ-QVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALIELG---------LKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
   |.. ||  . . ...| ... .... .. .|.||| ||.||.....|. |.  .         . .. ||...|..| ||. |  |. || ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

0040439 (Phosphotyrosine protein) phosphatases II 19-157 9e-27 89.7 In-house 51-241 (249) alignment
Range on Protein: 19-157
Range on HMM: 51-241/249.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPS---------------------------------------------YNTDELETQGITVKDL
| ...|..|. | . |.....  |........|.....                                              |. .... ..| . |.
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdw

AfEDGTFPPQQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
  ..|. |  . .....| ... .... .. .|.||| ||.||.....|. |.      |||. .| ||...|..|.||. |  |. || ..
p.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

0049772 (Phosphotyrosine protein) phosphatases II 19-158 3.8e-22 74.8 In-house 83-270 (314) alignment
Range on Protein: 19-158
Range on HMM: 83-270/314.0
YkgMKFLITDRPSDITINHY------------IMELKKNNVNTVVR---------------------VC------------------EPSYNTDELETQG
.  .||..|  |..||.. .            ...  ..|| ..|                       .                  |  |. . .| .|
f..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellkeelydpelferlg

ITVKDLAFEDGTFPPQQVVDEWFEVLKDKyqqNPEACVAVHCVAGLGRAP--VLVALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYK
|..... ..||..|. . .||..|....    ... .|.||| || ||..  |..|. .. ||. .| |.|..| ||   .|  .. .|| | 
ikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqye

0050432 (Phosphotyrosine protein) phosphatases II 19-149 4.4e-21 70.9 In-house 105-285 (308) alignment
Range on Protein: 19-149
Range on HMM: 105-285/308.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNT--------------DELETQGITVKDLAF-----------------------------
.. .||..|  | . |.....  . ..||...|..... .|               . ||  ..||. |                               
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

---EDGTFPPQ-QVVDEWFEVLKDKYqqnPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAINAK
   .|.  ||. . . ...| .....   |.  ..||| ||.||. ...|| |.      | |. .. || ..| .| |... .
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0046845 (Phosphotyrosine protein) phosphatases II 19-148 4e-18 61.3 In-house 74-259 (284) alignment
Range on Protein: 19-148
Range on HMM: 74-259/284.0
YKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNT---------------------------------------------DELETQGITVKDL
|. .||..|  | . |....   . ..||...| ..|.  |                                              .. . . .    .
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyt

AFEDGTFPP-QQVVDEWFEVLKDKYQQ-NPEACVAVHCVAGLGRAPVLVALALIELGLKYEA---------AVEMIRDKRRGAINA
.. |   ||  . . |... ... ... ...  ..||| ||.||. ...|| |.   |..|          || ..|..| |... 
swpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt

0049260 (Phosphotyrosine protein) phosphatases II 20-157 3.1e-33 110.0 In-house 7-145 (152) alignment
Range on Protein: 20-157
Range on HMM: 7-145/152.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVL
....|..|  | . |.....  ||.....|.|...|..... . . |.|... | ..|.. |.   . ...  . .|...... .|.|||.||.||...|
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VALALIELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
||. |..||...| ||...| || ||. |  || || ..
vaaylmllgvsleeavalvrekRpgavpnpgqlrflyef

0046846 (Phosphotyrosine protein) phosphatases II 20-158 1.5e-29 98.4 In-house 21-169 (176) alignment
Range on Protein: 20-158
Range on HMM: 21-169/176.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEP--------SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeACVAVHCVA
 | ....|. |   |. ... .||......||...|.         .  .|||. ||... | ..|.. |. . ..|..| ... ....   .|.|||.|
lgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsa

GLGRAPVLVALALIEL--GLKYEAAVEMIRDKRR-GAI-NAKQLSFLEKYK
|.||...|||. |.||  ||..| |....|..|. ||. . .|. ||... 
GigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe

0040438 (Phosphotyrosine protein) phosphatases II 20-157 3.5e-25 84.4 In-house 84-271 (317) alignment
Range on Protein: 20-157
Range on HMM: 84-271/317.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN------------------------TDELETQGITVKDLAF-------------------E
...||..|  | . |.....  .....|...|...|. ..                        ..| | .|||.  | .                    
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

DGTFPP-QQVVDEWFEVLKDKYQqNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
|...||  . . ...| ...... .|. .|.|||.||.||. ...|. |.      | |. .| ||...| .|.||. .  |. || ..
dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

0047943 (Phosphotyrosine protein) phosphatases II 20-153 2.4e-21 71.9 In-house 75-263 (273) alignment
Range on Protein: 20-153
Range on HMM: 75-263/273.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTD--------------ELETQGITVKD--------------------------------L
...||..|. | . |.....  ....||...|...|. ..                .|.   .||.                                 .
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhyt

AFEDGTFP-PQQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSF
 . |   |   . . |..|.........  .  |.|||.||.||. ...|| |.      | |. .. || ..|..| |.. .  |. |
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf

0051299 (Phosphotyrosine protein) phosphatases II 20-149 4.5e-19 64.4 In-house 90-272 (288) alignment
Range on Protein: 20-149
Range on HMM: 90-272/288.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPS------------------------YNTDELETQGITVKDLAFE-------------------
...||..|  | . |....   . ..||...|.....                         ....| . ...||  |  .                   
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

----DGTFPP-QQVVDEWFEVLKDKYQqNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAINAK
    |  .|.  . . .. . ...... ... .|.||| ||.||. ...|| |.      | |. .. ||...| .| |...  
tnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0036941 (Phosphotyrosine protein) phosphatases II 20-153 1.8e-18 62.3 In-house 76-268 (297) alignment
Range on Protein: 20-153
Range on HMM: 76-268/297.0
KGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN-------------TDELETQGITVKDLAFED-----------------------------
 ..||..|  | . |....   . ..||...| ..|.  .              ..|.  ..||. | .|                              
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhy

-----GTFPP-QQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALAL---------IELGLKYEAAVEMIRDKRRGAINAK-QLSF
        |.  . . ...| .......  ..  | |||.||.||. ...|. |         .| |. .  || ..|..| ||.    |. |
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf

0042113 (Phosphotyrosine protein) phosphatases II 21-157 6.3e-28 93.2 In-house 51-238 (245) alignment
Range on Protein: 21-157
Range on HMM: 51-238/245.0
GMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN-------------------------------------------TDELETQGITVKDLAFED
  ||..|. |.. |.....  |......|.|...|. ..                                            |  . ..|..  | ..|
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

GTFPP-QQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKY
.. |.  . .....| ... ......  |.||| ||.||. ...|. |.      |||.  | ||...|..|.||. .  |. || ..
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

0036282 (Phosphotyrosine protein) phosphatases II 21-157 2.5e-27 91.1 In-house 16-165 (174) alignment
Range on Protein: 21-157
Range on HMM: 16-165/174.0
GMKFLITDRPSDitinhYIMELKKNNVNTVVRVCEPSYNT------------DELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVH
  ...... | .     .. .||.....|||...|. ..             . ||  ||....| ..|.. |. ....|... ... ....|. .|.||
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CVAGLGRAPVLVALALIELGL--KYEAAVEMIRDKR----RGAINAKQLSFLEKY
| ||.||...|||. |.. ||  ... |....| .|    .. ..  |. || ..
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf

0039614 (Phosphotyrosine protein) phosphatases II 21-160 1.2e-26 89.4 In-house 100-287 (297) alignment
Range on Protein: 21-160
Range on HMM: 100-287/297.0
GMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN----------------------TDELETQGITVKDL-----------------AFEDGTFP
..||..|  |.. |.....  .....|...|..... ..                      ... . .|.||  |                  . |.. |
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvp

P-QQVVDEWFEVLKDKYQQN-PEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLEKYKPK
|  ....|..| ... .... .. .|.|||.||.||. ...|. |.      | |. .. ||...| .|.||. .  |. || ..  .
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

0043336 (Phosphotyrosine protein) phosphatases II 21-155 9e-24 79.8 In-house 87-270 (278) alignment
Range on Protein: 21-155
Range on HMM: 87-270/278.0
GMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYN------------------------------------------TDELETQGITVKDLAFEDG
..||..|  |.. |.....  .....|.|.|...|. ..                                           |  . ..  .  |.. |.
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

TFP-PQQVVDEWFEVLKDKYQqNPEACVAVHCVAGLGRAPVLVALALI------ELGLKYEAAVEMIRDKRRGAI-NAKQLSFLE
..| . . . .. ........ ... .|.|||.||.||. ...|| |.      |.|. .| ||...| .| ||. .  |. || 
gvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly

0038934 (Phosphotyrosine protein) phosphatases II 23-156 3.2e-35 116.9 In-house 19-171 (194) alignment
Range on Protein: 23-156
Range on HMM: 19-171/194.0
KFLITDRPSDITINHYIMELKKNNVNTVVRVC----------------EPSYNTDELETQGITVKDLAFED-GTFPPQQVVDEWFEVLKDKYQQNPEACV
.|.....|.. ....|| ||........||..                |. |...|.|  ||.. .| |.| || |...................|. .|
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAIN-AKQLSFLEK
||||.|||||...||| .||. ||...|.|....|.||.|||.  ..|. | |
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

0037934 (Phosphotyrosine protein) phosphatases II 23-157 1e-25 86.1 In-house 45-237 (243) alignment
Range on Protein: 23-157
Range on HMM: 45-237/243.0
KFLITDRPSDITINH----YIMELKKNNVNTVVRVCEPS------------------------------------------YNTDELETQGITVKDLAFE
.. .|. | . |...    ..  |........| ..|.                                           ...|.|. ..| .  |.. 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGTFPP-QQVVDEWFEVLKDKYQQ-------NPEACVAVHCVAGLGRAPVLVALALIEL--GLKYEAAVEMIRDKRRG-AI-NAKQLSFLEKY
|.. |.  . . .... ... ...       ...  |.|||.||.||. .|.|. |. |  |. .| ||...|..| | |. .  |. || ..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

0051429 (Phosphotyrosine protein) phosphatases II 23-157 3.2e-19 65.1 In-house 23-220 (272) alignment
Range on Protein: 23-157
Range on HMM: 23-220/272.0
KFLITDRPSDITINHYIMElKKNNVNTVVRVCEPS---YNTDELETQGITVKDLAFEDGTFPPQ------------------------------------
... ...|...|....    |.....|.| .....   ..  ... .||..  | ..| ..|.                                     
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------QVVDEWFEVLKDkyqqnpEACVAVHCVAGLGRAPVLVALALIELGLK--------------YEAAVEMIRDKRRGAI-NAKQLS
                . . |..|.| |      .  | ||| || .|  ..||| |. ||.               .|.|||..|..|.||. .  |. 
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

FLEKY
|| ..
flyea

0044763 (Phosphotyrosine protein) phosphatases II 24-160 2.6e-26 87.8 In-house 30-169 (178) alignment
Range on Protein: 24-160
Range on HMM: 30-169/178.0
FLITDRPSditiNHYIMELKKNNVNTVVRVCEPSY------NTDELETQGITVKDLAFEDGTFPP-QQVVDEWFEVLKDKYQQNPeACVAVHCVAGLGRA
..... |.     ...  ||.......|...|. .      .   .|  ||... . ..|.. |.  . ..|..| ... .....  .|.||| ||.||.
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRs

PVLVALALI-ELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPK
..|||. |. .||| .|.|.|..| .|.. .|  || .|... ..
gtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelr

0051082 (Phosphotyrosine protein) phosphatases II 24-154 4e-24 80.3 In-house 15-144 (151) alignment
Range on Protein: 24-154
Range on HMM: 15-144/151.0
FLITDRPSDitinHYIMELKKNNVNTVVRVCEPS---YNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLV
..... |..    ... .||.....|.| ....    |... |. .||.|... ..| ..|. ..  ...  . ........ .|.||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALALIELGLKYEAAVEMIRDKRRGAINAKQLSFL
|| |. ||. .|.|.|..| || |... .|  ..
alylmllgvsleealeeyrlkrpgvvqpnqqflf

0048179 (Phosphotyrosine protein) phosphatases II 36-158 2.9e-22 74.4 In-house 19-141 (144) alignment
Range on Protein: 36-158
Range on HMM: 19-141/144.0
NHYIMELKKNNVNTVVRVCEPsYNTDELETQGITVKDLAFEDGTFPPQ-QVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALI-ELGLKYEA
 . . .|||....||....|. |  ..|| .||..  | ..|   |.  . ..|..| ... ....   .|.||| ||.||...|||. |. .||| .| 
aldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglslee

AVEMIRDKRRGAI-NAKQLSFLEKYK
|....| .| ||. |  || ||..| 
alalvrsrrpgavpnpgqlrfLleye

subfamily_CDC14_pd Subfamily CDC14 36-157 8.6e-22 72.4 In-house 202-319 (328) alignment
Range on Protein: 36-157
Range on HMM: 202-319/328.0
NHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKyqqnpEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAA
....   .||||.||||. .  |.  . . .|.  ||| |.||. |....| .. |....      |  .|||| |||||.  |.|  |. . ..  . |
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VEMIRDKRRGAINAKQLSFLEKY
.  .|  | | . ..| .|||. 
iawlricrPGsvigpqqkfleek

subfamily_PTPMT1_pd Subfamily PTPMT1 36-159 4.5e-10 34.2 In-house 35-166 (171) alignment
Range on Protein: 36-159
Range on HMM: 35-166/171.0
NHYIMEL-KKNNVNTVVRVCEPSY------NTDELETQGITVKDLAFEDGT-FPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALI-E
...| || .|.||..|| ..|         .|.| . .|..   ||  | |  | .. . .  |....   ..   .| ||| || ||.  |||  |. .
rslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkk

LGLKYEAAVEMIRDKRRG-AINAKQLSFLEKYKP
  |. | |......||.   .. ||.. |..|. 
eklspeeAlkalkkkRkiirlakkqwkalqeyee

PTEN_1 37-157 7.5e-24 79.6 In-house 58-188 (196) alignment
Range on Protein: 37-157
Range on HMM: 58-188/196.0
HYIMELKKNNVNTVVRVCE------PSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNP-EACVAVHCVAGLGRAPVLVALALIELG-
 .  .||.... .||...|      .||. .| . .|...... .|| . |. . . .. ..... ....| . .|.||| |||||  ..||  |...| 
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

LKYEAAVEMIRDKR-RGAIN-AKQLSFLEKY
| .. |.|..|.|| .||.| ..|  .|| .
ltadeAlelvrekRppgapnspsqerlleyf

0048076 (Phosphotyrosine protein) phosphatases II 37-158 6.3e-21 70.0 In-house 20-139 (145) alignment
Range on Protein: 37-158
Range on HMM: 20-139/145.0
HYIMELKKNNVNTVVRVcepSYNTDELETQGITVKDLAFEDGTFPPQ-QVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALIEL-GLKYEAA
. . .||.... ||...   ..... || .||..  | ..| . |.  . ..|..| ... ....   .|.||| ||.||...|||. |. | |. .| |
ldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleea

VEMIRDKRRGAI-NAKQLSFLEKYK
.|..| .|.||. |  || ||... 
lelvrsqrpgavpnpgqlrflyefe

subfamily_PTEN_pd Subfamily PTEN 39-133 5.1e-09 31.4 In-house 54-145 (184) alignment
Range on Protein: 39-133
Range on HMM: 54-145/184.0
IMELKKNNVNTVVRVCEPSYNTDELETQgitVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEA
. . .|....      | .|........   |. . |.| . || ....|  | ...  .....  |.||| || ||. ||..  |.. .|  .|
lekkhkdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka

subfamily_DSP19_pd Subfamily DSP19 39-145 4e-08 27.7 In-house 30-133 (152) alignment
Range on Protein: 39-145
Range on HMM: 30-133/152.0
IMELKKNNVNTVVRVCEPSYN--TDELETQGITVKDLAFEDGTfppqQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAP-VLVALALIELGLKYEAAV
  .||....  .. |     |  ....... | . ||  .| .    .. .| .. ...  ...   .| ||| ||  |.. | .|  . .  |..| |.
keilkekkitHilnvatgvpnvfpkdftylsieilDlpetdll....sylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeelsleeal

EMIRDKRRGA
|..|..|. .
elvrearpci

subfamily_RNGTT_pd Subfamily RNGTT 40-150 3.8e-12 40.3 In-house 48-162 (189) alignment
Range on Protein: 40-150
Range on HMM: 48-162/189.0
MELKKNNVNTVVRVC--EPSYNTDELETQGITVKDLAFE-DGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAV
....|...  |. .   .. |...|||..||. . |. .  |  | .. |.|. ..... ...|||  ..|||  |  |.  |..  |.|    . ||||
lktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaav

EMIRDKRRGAINAKQ
.. .  |   |  ..
alFakaRppGiyked

subfamily_DSP12_pd Subfamily DSP12 40-153 5.1e-07 24.2 In-house 21-135 (155) alignment
Range on Protein: 40-153
Range on HMM: 21-135/155.0
MELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGT-FPPQQVVDEWFEVLKDKYqqNPEACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEM
  ||. ... |. | . . .. .|... .. | .   |    .  .  || .. ...    . |  | ||| ||. |   . .|  . . .|. | |...
ellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlkl

IRDKRRGA-INAKQLSF
...|.. .  |.  |. 
vkekkpeiepNegFleQ

subfamily_Slingshot_pd Subfamily Slingshot 40-155 1.9e-06 21.4 In-house 38-151 (169) alignment
Range on Protein: 40-155
Range on HMM: 38-151/169.0
MELKKNNVNTVVRVCE--PSYNTDELETQGITVKDLAFEDgtFppQQVVDEWFEVLKDKYQQnpEACVAVHCVAGLGR-APVLVALALIELGLKYEAAVE
 |||.|.|. .. | .   ..  ...| . | | |   .|  .   .  .| .. ..   ..  .. | |||  |. | | ...| |. | ||..| |.|
eelkengveyilnvtkeidnffpekfeylnirvydeeetd..l..lkywnetykfiekakkk..gskvlvhckmGvsrsastviayamkeyglsleeale

MIRDKRRGAI-NAKQLSFLE
 ....|. .  |.  |. ||
yvkerrsvikPnkgflkqle

PTPc_motif_SM00404 41-155 2.6e-10 35.3 In-house 22-132 (140) alignment
Range on Protein: 41-155
Range on HMM: 22-132/140.0
ELKKNNVNTVVRVCEPSYNTdeLETQGITVKDLAFED-GTFPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALI-ELGLKYEAAVEMI
 |||... .|. | |   .|   |..|.... .  .| .. . ..  |.  .....   .. .  | ||| ||. |   |..  |. . .|....|.|..
llkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefv

RDKRrgAINAKQLSFLE
...|   |  ..|.|..
kerR..piispnlnfvr

DSPc Dual specificity phosphatase, catalytic domain 41-148 2.3e-09 32.2 Pfam-A 13-119 (133) alignment
Range on Protein: 41-148
Range on HMM: 13-119/133.0
ELKKNNVNTVVRVCEPS-----YNTDELETQGITVKDlafeDGTFPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAA
 |.|.... |. | .       ... | |  .| |.|    . .   ..  .|  |....   .. .  |.||| ||. | . |..  |..  .|... |
lleklgitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA

VEMIRDKRrGAINA
.|.....| ..|. 
yefvkerr.skisp

DSPc Dual specificity phosphatase, catalytic domain 41-148 2.3e-09 32.2 In-house 13-119 (133) alignment
Range on Protein: 41-148
Range on HMM: 13-119/133.0
ELKKNNVNTVVRVCEPS-----YNTDELETQGITVKDlafeDGTFPPQQVVDEWFEVLKDKyqQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAA
 |.|.... |. | .       ... | |  .| |.|    . .   ..  .|  |....   .. .  |.||| ||. | . |..  |..  .|... |
lleklgitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA

VEMIRDKRrGAINA
.|.....| ..|. 
yefvkerr.skisp

subfamily_DSP15_pd Subfamily DSP15 41-157 2.8e-08 28.0 In-house 22-135 (151) alignment
Range on Protein: 41-157
Range on HMM: 22-135/151.0
ELKKNNVNTVVRVCEpsyNTDELETQgITVKDLAFEDGtfpPQQVVDEWFEVLKDKY--QQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEM
 ||..|. ... | .   |. .|  . |. | .| .|    |.. ....|.   .     .  |  | |||.||. |.  ||.. |.  . |... |.|.
lLkeknithilsvhd...nakkllkd.ieYkciaasDt...psaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalev

IRDKRRGAI-NAKQLSFLEKY
|. .|  |  |.   . |..|
ikaaRsvanPnfGfkrqlkey

0048567 (Phosphotyrosine protein) phosphatases II 42-156 5.6e-10 33.8 In-house 12-132 (157) alignment
Range on Protein: 42-156
Range on HMM: 12-132/157.0
LKKNNVNTVVRVCEPSYNTDEL-ETQGITVKDLAFEDGtFPPQQVVDEWFEVLKDKYQ--QNPEACVAVHCVAGL---GRAPVLVAL-ALIELGLKYEAA
 .. ......|. .  ||.  .  ..|.   |. |..|  ..  .. ... .|.....  .. .  .|||| |||   ||. .|... ... ||.  | |
pdrlyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeea

VEMIRDKRRGAINAKQLSFLEK
....|  | | .   . |.|. 
iaplrivrpgsvpfrdasylls

subfamily_DSP10_pd Subfamily DSP10 42-155 2.3e-06 21.6 In-house 35-144 (159) alignment
Range on Protein: 42-155
Range on HMM: 35-144/159.0
LKKNNVNTVVRVCEPSYNT---DELETQGITVKDLAFEDgtfpPQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRA-PVLVALALIELGLKYEAAVEM
|.. |...|. |   . |.   ..|. . | |.|   ..     .|  .| .| ...  ...  . | ||| ||. |.  | .|  . .|.|. . | ..
ldrlnitavlnvttsvPnefeeealkYkripvsDtskqn....lkqyfeealefieearkkg..srvLvhCqaGisrsatvviaYlmkhlnlslndaykf

IRDKRrgAINAKQLSFLE
...||  .| .  |.|. 
vkekr..piisPnLnfmG

subfamily_DSP8_pd Subfamily DSP8 44-156 3.7e-06 20.6 In-house 38-146 (159) alignment
Range on Protein: 44-156
Range on HMM: 38-146/159.0
KNNVNTVVRVCEPSYNTDELETQG---ITVKDLAFEDgTFPpqqVVDEWFEVLkDKYQQNpEACVAVHCVAGLGRAP-VLVALALIELGLKYEAAVEMIR
|.... |. . .   ...||. .    . |||   |.   |   . |. .| . || ... ...| ||. ||  |.. | .|  . .| .... | . ..
klgisyvlnasnscpkleelkeskflrvPvkDkydek.llp...wfdksvefi.dkakse.ngrvlvhvlaGisrsatvaiayimktlemsldeayrfvk

DKRrGAINaKQLSFLEK
.||  .|. ..| ||..
ekr.ptis.pnlnflgq

subfamily_PTPDC1_pd Subfamily PTPDC1 57-157 1e-13 46.1 In-house 72-171 (182) alignment
Range on Protein: 57-157
Range on HMM: 72-171/182.0
SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeaCVAVHCVAGLGRAPVLVALALI-ELGLKYEAAVEMIRDKRRGAINAK-QLSFL
||....|  |||.|  ....|   .. . . .   |..   |..    ||||| |||||. ||.|  |.    |. | |....|.||  .|... |. ..
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

EKY
...
kef

subfamily_DSP11_pd Subfamily DSP11 57-146 1.2e-08 29.0 In-house 69-161 (178) alignment
Range on Protein: 57-146
Range on HMM: 69-161/178.0
SYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKY--QQNPEACVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAI
 |...||. .|.. . |     ..| ...|... |..|.    ... .. ..|||  |. |.  |.   ||.  |.. | |.|.  . |  ..
yykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsl

subfamily_DSP3_pd Subfamily DSP3 57-158 2.8e-06 21.1 In-house 57-154 (162) alignment
Range on Protein: 57-158
Range on HMM: 57-154/162.0
SYNTDELETQGITVKDLAFEDgtfpPQQVVDEWFEVLKDKYQQnPEACVAVHCVAGLGRAPVLV-ALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLE
 |.  |..  |. |.|    |     ..  .. .. ...  .| .|. | ||||.|. |...|| |  .|   ..   |.. .|.||.   |   |  | 
fykdleikylGlevdDvpefd....lskyFetaakfidealsq.kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLa

KYK
...
eld

subfamily_CDKN3_pd Subfamily CDKN3 61-160 3.1e-08 27.4 In-house 93-194 (202) alignment
Range on Protein: 61-160
Range on HMM: 93-194/202.0
DELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpeACVAVHCVAGLGRAPVLVALALIEL--GLKYEAAVEMIRDKR-RGAIN-AKQLSFLEK
|. .. |..|.   . ||. |      . .| |.   ..       |||  ||||. ...|  |. |   .... |.. .|| .  .||.  ||  .|..
dlyqqaglivhhypiadglvpdiasclkileelrinlkay..rktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylse

YKPK
.. |
frdk

subfamily_DSP23_pd Subfamily DSP23 62-148 9.5e-10 33.3 In-house 47-131 (148) alignment
Range on Protein: 62-148
Range on HMM: 47-131/148.0
ElETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNpEAcVAVHCVAGLGRAPVLVALALIE-LGLKYEAAVEMIRDKRRGAINA
|  | ..|.. |  .| . |  . |.|. .|...  ..| || |.|||. | ||.  ..|  |.   .|    |.  .| .| |....
e.atpnltlvrlriddyhppaleqvvefvrvveeaeekn.ea.vsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet

PTPc_DSPc_SM00012 84-149 6.2e-09 31.4 In-house 20-93 (105) alignment
Range on Protein: 84-149
Range on HMM: 20-93/105.0
QVVDEWFEVLKDKYQQNP-EACVAVHCVAGLGRAPVLVALALIELGLKYEA-------AVEMIRDKRRGAINAK
. . |... .|......  .. | ||| || ||. ..|||...   |..|         |...|..|.|... .
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 88-138 1.4e-06 22.7 In-house 203-259 (297) alignment
Range on Protein: 88-138
Range on HMM: 203-259/297.0
EWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVE------MI
.. . ......|| |. . |||.||.||. ||...  .    | | .|.      ..
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkkl

Y_phosphatase Protein-tyrosine phosphatase 90-154 1.7e-07 26.3 Pfam-A 156-229 (235) alignment
Range on Protein: 90-154
Range on HMM: 156-229/235.0
FEVLKDKYQ--QNPEACVAVHCVAGLGRAPVLVALALIELGLKY------EAAVEMIRDKRRGAINA-KQLSFL
......  .  .. .. | ||| || ||. ..||| ..   |.         .|...| .|.|...  .|. ||
ldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

Y_phosphatase Protein-tyrosine phosphatase 90-154 1.7e-07 26.3 In-house 156-229 (235) alignment
Range on Protein: 90-154
Range on HMM: 156-229/235.0
FEVLKDKYQ--QNPEACVAVHCVAGLGRAPVLVALALIELGLKY------EAAVEMIRDKRRGAINA-KQLSFL
......  .  .. .. | ||| || ||. ..||| ..   |.         .|...| .|.|...  .|. ||
ldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

subfamily_Ptp69D_pd Subfamily Ptp69D 90-138 8.7e-06 20.1 In-house 208-255 (307) alignment
Range on Protein: 90-138
Range on HMM: 208-255/307.0
FEVLKDKYQQNpEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMI
 | ... |..| .. . ||| || ||. ..|||...   || |  |...
ieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif