Gene ssh in Drosophila melanogaster

Synonym: CG6238, Dmel\CG6238, MKP, Mkph, SSH, Ssh, l(3)01207, Dmel_CG6238, ssh

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP026_AA protein Get Run
DmelP026_AA_382-527 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DEK_C DEK C terminal domain 327-379 5.6e-18 54.1 Pfam-A 1-53 (54) alignment 
Range on Protein: 327-379
Range on HMM: 1-53/54.0
TESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVIL
|.. || ....|....||..||.| .| .||. |..|| |.|.||....  .|
tdeeikeevreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdlieefL
subfamily_Slingshot_pd Subfamily Slingshot 367-531 5.7e-91 296.4 In-house 1-166 (169) alignment 
Range on Protein: 367-531
Range on HMM: 1-166/169.0
YKSFIDAEMLVILGQMDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVL
||.|||.||||||||.|...|||.||||||||||||||||..|||..|||||.|||||||..|||.|.||||.|.|.|||||..|...|..||..|||||
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAMKNKE-K
||||||||||||.|||||||.|......|||.||.|||.|||||.||.|||.|.|.|.|.|... |
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhnk
0049772 (Phosphotyrosine protein) phosphatases II 371-536 1.6e-34 115.5 In-house 119-286 (314) alignment 
Range on Protein: 371-536
Range on HMM: 119-286/314.0
IDAEMLVI---------------------LGQMDAPTkifehvylgSEWNASNLEELQkngvrhilnvtREI--DNFFPGT-FEYFNVRVYDdEKTNLLK
..  ..|.                     | ..| ..         .|..|..||.|.           .|.  ...|... ..|... |.| . ..||.
lnvrdivmsrdevladelsrLdaAlgKtpllildgng.........neptaadlellk...........eelydpelferlgikylripvpD.gsaplle

YWDDTFRYITRAkAEGSKVLVHCKMGVSRSAS-VVIAYAMKAYQWEFQQALEHVKKRRScIKPNKNFLNQLETYSGMLDAMKNKEKLQRSK
..|. ...| .|  .|..||||||.|..|... ||.|| ||.... ...|||.|...|. |.||..|..||| |  .|.|.... | ....
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkkf
subfamily_LRR-DSP_pd Subfamily LRR-DSP 372-521 2.3e-34 112.7 In-house 108-256 (263) alignment 
Range on Protein: 372-521
Range on HMM: 108-256/263.0
DAEMLVILgQMDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNV-RVYDDEKTNLLKYWDDTFRYITRAKAEGSkVLVHCK
. | |..| .   | .| ....||.   | |   |...|| |||    ... .|| .| |. .  . | .. .. .....|  .|   . .|  |||||.
qveslitl.vssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcr

MGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSG
 |||||...||.| ||  . .|..||. |.|.|. |.||. |..||  |  
aGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0044763 (Phosphotyrosine protein) phosphatases II 377-524 1.4e-40 134.2 In-house 15-171 (178) alignment 
Range on Protein: 377-524
Range on HMM: 15-171/178.0
VILGQMDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGT---------FEYFNVRVYDDEKTNLLKYWDDTFRYITRAK-AEGSKVL
.  ...  ...|....|||| ..|..|| |...|..||.|.| |. ..|...         ..|... . |.  ..||.........| .|   .|..||
lersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvl

VHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRScIKPNKNFLNQLETYSGMLD
|||..||.||...|.|| || ... ...|.|.|..||. | || ..|.||. .  .| 
VHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP6_pd Subfamily DSP6 382-524 2.8e-40 131.4 In-house 11-155 (158) alignment 
Range on Protein: 382-524
Range on HMM: 11-155/158.0
MDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFP--GTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASV
  .| .| ...||||. .||||| |.| .....|||| ...|.|   | ..| .. . |  ..|| |.. .....|  |. . |||||||  |.|||  |
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

VIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLD
..|| || ..  ...| . ||||.| | || ||..||  .  .| 
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
0046846 (Phosphotyrosine protein) phosphatases II 382-519 6e-28 93.2 In-house 9-168 (176) alignment 
Range on Protein: 382-519
Range on HMM: 9-168/176.0
MDAPTKIFEHVYLGSEW----------NASNLEELQKNGVRHILNVTREI-------DNFFP----GTFEYFNVRVYDDEKTNLlKYWDDTFRYITRAKA
   .. | ....||| .           |..||.|...|.....|.| |.       .|..|      ..|... . |    .| ..... ...| .|  
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

EGSKVLVHCKMGVSRSASVVIAYAMKA-YQWEFQQALEHVKKRRS-CIKPNKNFLNQLETY
|| .|||||..|..|.. .|.|| ..  ...  ..||..|...|. .. .. ... .|. .
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
0045098 (Phosphotyrosine protein) phosphatases II 382-519 9.4e-28 92.8 In-house 19-267 (278) alignment 
Range on Protein: 382-519
Range on HMM: 19-267/278.0
MDAPTKIFEHVYLGSEW-----------------------------------------NASNLEELQKNGVRHILNVTREIDN-----------------
.  | .|....|||. .                                          |.... |...|...|...|.....                 
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

-----------------------------------FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKA--------------EGSKVLVHCKMGVS
                                   ..   . |...  ..   ...||.... ...| .| .              .| .|||||..||.
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSASVVIAYAMKAY---QWEFQQALEHVKKRRSC-IKPNKNFLNQLETY
|.. .|.|| |. .   .. ...|.......| . . .|......|. .
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyef
subfamily_DSP8_pd Subfamily DSP8 383-523 7.1e-33 107.4 In-house 13-154 (159) alignment 
Range on Protein: 383-523
Range on HMM: 13-154/159.0
DAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTRE-IDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVI
. ||.| ...||||. .. . | |.|.|. ..||. .. ..  .    ... | | |. . .|| ..| .. .| .||.| ..||||.  | ||||.|.|
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGML
|| ||  . ....| ..||..|  |.|| |||.||  |   |
ayimktlemsldeayrfvkekrptispnlnflgqLleyekel
0043147 (Phosphotyrosine protein) phosphatases II 383-526 8.7e-32 105.6 In-house 17-163 (172) alignment 
Range on Protein: 383-526
Range on HMM: 17-163/172.0
DAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTRE---IDNFFPGTFEYFNVRVYDDEKTnLLKYWDDTFRYITR--AKAEGSKVLVHCKMGVSRSA
  |.... . .....  |.... |...|..||.|.|..    .....  ..|  . ..|   . ||.........| .  |. .| .|||||..||.|..
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg

SVVIAYAMKaYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAM
 .|.|| |. ... ...|...|...|... .|......|  .. .|  .
tlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
0041856 (Phosphotyrosine protein) phosphatases II 384-522 2.6e-31 104.0 In-house 18-171 (182) alignment 
Range on Protein: 384-522
Range on HMM: 18-171/182.0
APTKIFEHVYLGSEWN--------------ASNLEELQKNGVRHILNVTREI---DNFFPGTFEYFNVRVYDDEKTNllkyWDDTFRYITRAKAEGSKVL
 ...| ...|||| ..              |..|. |...|...|.|.| |    ...    ..|... . |.. ..    .|.....| ....|| .||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRS--CIKPNKNFLNQLETYSGM
|||..||.|....|.|| || ... ...|...|..||.  .| || .|. ||  .  .
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_DSP1_pd Subfamily DSP1 385-524 5.1e-46 150.7 In-house 17-157 (163) alignment 
Range on Protein: 385-524
Range on HMM: 17-157/163.0
PTK-IFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAY
|.. | ...||||| .||||| |...|. .||||..|.||.|. .||| .. . | .| .. .....   .| ..|... |||.||..|.|||.....||
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclay

AMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLD
 ||  ......| . ||.|||.|.|| .| .|| .|   | 
lmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
PTPc_motif_SM00404 385-519 1.4e-41 136.6 In-house 2-137 (140) alignment 
Range on Protein: 385-519
Range on HMM: 2-137/140.0
PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDN-FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAY
|..| .|.||||. .|.|.. |.|.|..|..|||.|...      |..... . |.||..|.||.| . ..| .|...| ||||||..||||||...|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

AMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY
 |. .|.. ..|.| ||.||..|.|| ||..||  |
lmryrqlslaeayefvkerRpiispnlnfvrqLiey
subfamily_DSP10_pd Subfamily DSP10 385-526 6.5e-40 130.6 In-house 14-156 (159) alignment 
Range on Protein: 385-526
Range on HMM: 14-156/159.0
PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPG-TFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAY
 .... ...|||| .|..|. |.. .. ..|||| .. |.| . ...|  . | | .| || .|... . .|  |. .||.|||||. |.||||.|||||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

AMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAM
 ||  .  ...| ..||..|. | || ||. ||  .   |. .
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
0048076 (Phosphotyrosine protein) phosphatases II 385-520 1.1e-37 124.2 In-house 4-139 (145) alignment 
Range on Protein: 385-520
Range on HMM: 4-139/145.0
PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYA
|..|....|||| ..|..||.|...|....||.|.|......  ..|... . | .  .||..... ...| .| .|| .|||||..||.|....|.|| 
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS
|. ... ...|||.|...|... || ..|..|. . 
mlllgvsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 385-522 1.4e-36 120.7 In-house 4-143 (144) alignment 
Range on Protein: 385-522
Range on HMM: 4-143/144.0
PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTF--EYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIA
|..|....|||| . |..||.|.|.|.....|.| | .. |.. .  .|... . | .  .||.........| .| .|| .|||||..||.|....|.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM
| || ... ...||..|..||... || ..|..|. |. .
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP14_pd Subfamily DSP14 385-526 8.6e-36 117.3 In-house 7-147 (157) alignment 
Range on Protein: 385-526
Range on HMM: 7-147/157.0
PTKIFEHVYLGsEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYA
 ..| .. .|.    |.. |.|.|... .|.|||.|. |     .|. .|.| |.....| |..| .  .|  .|..| |.||||..|||||||...|| 
lsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAM
||  .   ..| ..||..|. |.||  | .|| .|   | . 
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 385-520 3.1e-28 92.0 In-house 3-149 (154) alignment 
Range on Protein: 385-520
Range on HMM: 3-149/154.0
PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGT---------FEYFNVRVYDDEKTNLLKYWDDTFRYITRAK--AEGSKVLVHCKMGV
..|   ..|..|   | |  .||.. ...||||   |.| |.           .|| |....|| . ....  | .| .|  |    | .|||||.. ||
nskeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGv

SRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS
||||...|.| |.  .  . .||| .|. |  ||||. ||.||| . 
srsaallisylmdklkislslalellkdsryiikPnqGflkqleife
0049260 (Phosphotyrosine protein) phosphatases II 385-523 3.9e-28 93.5 In-house 8-149 (152) alignment 
Range on Protein: 385-523
Range on HMM: 8-149/152.0
PTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDN---FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITR-AKAEGSKVLVHCKMGVSRSASVV
|...  . ..|... |.... |...|...|...|.. ..   ...  ..|... . |.   .|  . .. .. | . |. .| .|||||. ||.|.. .|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYAMKaYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGML
.|| |. .......|...|...|... ||...| .|  ....|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0036941 (Phosphotyrosine protein) phosphatases II 385-518 4.5e-19 64.3 In-house 19-271 (297) alignment 
Range on Protein: 385-518
Range on HMM: 19-271/297.0
PTKIFEHVYLGSEWNASNLEELQKN----------------------------------------------------------GVRHILNVTREIDNFFP
  ..... .||| . |...| |.||                                                          .|..|...|..... ..
feellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

GTFEYFNVR-------------VYD----------------------------------DEKTNLLKYWDDTFRYITRAKA------EGSKVLVHCKMGV
  ..|.                . .                                      ..  .... ...| ...       .|..|||||..||
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSASVVIAYAM--------KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLET
.||.....|. |        | ... . .|. .....| .. .. ... .|  
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye
subfamily_DSP12_pd Subfamily DSP12 386-531 1.8e-38 126.4 In-house 3-151 (155) alignment 
Range on Protein: 386-531
Range on HMM: 3-151/155.0
TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTRE-ID--NFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIA
..| . .|||.  .. . | |.. .. |.| |..| ..  .  .|. .. .. ..|......|.. |.....|  | .|. .|||||..|||||...|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAMKNKEK
| || .......||. ||. .. |.||..||.||  .  |   . ...|
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnk
subfamily_DSP15_pd Subfamily DSP15 386-532 4e-31 102.2 In-house 3-147 (151) alignment 
Range on Protein: 386-532
Range on HMM: 3-147/151.0
TKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGtFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAM
.|. . .|||   .... | |... . |||.|  .  ....  .||  ... |  ...| |. ... ..| ... .. .||||| .|||||. .|.|| |
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMlDAMKNKEKL
 . . ....||| .|..||. .||  | .||. |. .  . . ...|
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt.klkeyrkql
PTEN_1 386-525 1.4e-28 95.1 In-house 37-193 (196) alignment 
Range on Protein: 386-525
Range on HMM: 37-193/196.0
T-----KIFEHVYLGSEWNA-SNLEELQKNGVRHILNVTREIDN---------FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKA--EGSKVLVH
.     .|.|..|.||.  . ..|..|...|.....|.. | ..         || . .|| .. . |. . .| . .|   . |  ...  .| .||||
srpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVH

CKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDA
|| |..||. ||.|| |..... ...|||.|...|... ||  ....|. |  .| |
CkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0036282 (Phosphotyrosine protein) phosphatases II 386-523 2.6e-25 84.5 In-house 13-169 (174) alignment 
Range on Protein: 386-523
Range on HMM: 13-169/174.0
TKIFEHVYLGSEWNAsNLEELQKNGVRHILNVTREI---------------DNFFPGTFEYFNVRVYDDEKTNLLKyWDDTFRYITRAKAE--GSKVLVH
. | .....|.   | ..|.|...|.........|.               . . .  ..|. . . |..  .| . ... .... .| .|  | .||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CKMGVSRSASVVIAYAMKAYQW-EFQQALEHVKKRR---SCIKPNKNFLNQLETYSGML
|..||.|.. .|.|| |. ...  ...||..|...|   ... .. ... .|  .. .|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0037934 (Phosphotyrosine protein) phosphatases II 386-519 1.7e-24 82.1 In-house 40-237 (243) alignment 
Range on Protein: 386-519
Range on HMM: 40-237/243.0
TKIFEHVYLGSE--------WNASNLEELQKNGVRHILNVTREI---------------------------------------------DNFFPGTFEYF
...........         . ||... |...|...|...|...                                             |...   . | 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NVRVYD----DEKTNLLKYWDDTFRYITR-----AKAEGSKVLVHCKMGVSRSASVVIAYAMKAY-QWEFQQALEHVKKRRSC-IKPNKNFLNQLETY
 . . |    |. ..||...|..  .| .     |  .|..|||||..||.|.. ...|| |. . .. ...|.......|.. . .. ... .|  .
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_DSP19_pd Subfamily DSP19 387-520 2.9e-43 141.8 In-house 14-147 (152) alignment 
Range on Protein: 387-520
Range on HMM: 14-147/152.0
KIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMK
.. ...||||   |.. |.|..... |||||. ...|.||  |.| .. ..|...|.||.|..... .|  |. .   |||||. |||||||||||| ||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

AYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS
  . ....||| |.. | |||||. |..||..| 
keelsleealelvrearpcikPneGFikqLkeye
subfamily_DSP3_pd Subfamily DSP3 387-523 1.2e-31 103.5 In-house 13-157 (162) alignment 
Range on Protein: 387-523
Range on HMM: 13-157/162.0
KIFEHVYLGSEWNASNLEELQKNGVRHILNVTRE----I---DNFFP-GTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAE-GSKVLVHCKMGVSRSA
 .....|.| |  |.. ..|.| |. |.|| ..     .   ..|.    ..|. . | |  ...| ||.. ....| .| ..  .||||||..||||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

SVVIAYAMKAYQWEFQQALEHVKKRRsCIKPNKNFLNQLETYSGML
 .|.|| |   . . ..|...|.|.| .| ||. ||.|| ...  |
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel
0042113 (Phosphotyrosine protein) phosphatases II 387-519 1.9e-22 75.3 In-house 49-238 (245) alignment 
Range on Protein: 387-519
Range on HMM: 49-238/245.0
KIFEHVYLGSEWNASNLE----ELQKNGVRHILNVTREIDN----------------------------------------------FFPGTFEYFNVRV
.| .......   ....|     |...|...|...|.| ..                                              .    . |. . .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

YDDEKTNLLKYWDDTFRYITRAKA--EGSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY
 |.  ..||.. .| .... .| |  .. .|||||..||.|.. ...|| |     | . . ...|.......|... .. ... .|  .
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_STYX_pd Subfamily STYX 388-523 1.3e-26 86.6 In-house 15-157 (166) alignment 
Range on Protein: 388-523
Range on HMM: 15-157/166.0
IFEHVYLGSE--WNASNLEELQKNGVRHILNVTREID-----NFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVV
|.  ..||       | || |.|.|. ||. . ..|.       || .| |. . | |.   |...|   .  .|  .  .| ||||| . |.||||..|
ilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

IAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGML
||| |..|  ....|  .|..|| ||.||. | .||. |  . 
iayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
0040439 (Phosphotyrosine protein) phosphatases II 388-519 1.1e-24 82.8 In-house 32-241 (249) alignment 
Range on Protein: 388-519
Range on HMM: 32-241/249.0
IFEHVYLGSEWNASNLE------------------------ELQKNGVRHILNVTREIDN----------------------------------------
|.. ..|..  ||| ..                         |...|...|...|..  .                                        
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKA------EGSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPN
    .. ....  ....|   ... .. .|....| ...       .|..|||||..||.|.. ...|| |     | ... ...|.......|... .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

KNFLNQLETY
 ... .|  .
peqyrflyea
0051082 (Phosphotyrosine protein) phosphatases II 388-517 4.4e-22 73.7 In-house 11-147 (151) alignment 
Range on Protein: 388-517
Range on HMM: 11-147/151.0
IFEHVYLGSEWNASNLEELQKNGVRHILNVTREI-----DNFFPG-TFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAE-GSKVLVHCKMGVSRSASVV
. ...|...   | .||.|...|...|.|.. |       ...|   .|.... . |.  ..|  ..|   ...  . .  . .|||||..|..|.. .|
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

IAYAMKaYQWEFQQALEHVKKRRS-CIKPNKNFLNQLE
..| |. ... ...|||.....|  .. ||  || || 
alylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0038934 (Phosphotyrosine protein) phosphatases II 388-522 1.5e-19 65.8 In-house 34-175 (194) alignment 
Range on Protein: 388-522
Range on HMM: 34-175/194.0
IFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVY-----DDE---KTNLLKYWDDTFRYITrAKAEGSKVLVHCKMGVSRSASV
 .| .|  | ..  .. .|.. ........| .   . |  ||  .....     ||     ...|. . |    .. .. .| .|.||||.|..|.. .
yieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtl

VIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM
|.|| .. ...  ..|..... .|  . || ..|..| .. ..
vaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryke
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 390-519 7.1e-33 107.2 In-house 13-143 (148) alignment 
Range on Protein: 390-519
Range on HMM: 13-143/148.0
EHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPG-TFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAY
 ...|||   |..|| |.. || .| | |.| || .   . ||..|.. |..| .| ....|   ....||.|| .||||..||||||. ..... ..  
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

QWEFQQALEHVKKRRSCIKPNKNFLNQLETY
.   ..||. || .|  ..||. ||.||  .
rvslkealalvkskrryvdpnlgfLkqLael
subfamily_MKPLT_pd Subfamily MKPLT 390-522 1.7e-32 106.2 In-house 27-159 (164) alignment 
Range on Protein: 390-522
Range on HMM: 27-159/164.0
EHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQ
...|||   .| | . |..  . ||.||..|  . || ..|| .|.| |  ...| .. . .  ... |   | .||||| .|.|||.|| .|. .|  .
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

WEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM
| ...| |..|.|||...||. || || ..  .
wtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 390-522 1.7e-32 106.2 In-house 27-159 (164) alignment 
Range on Protein: 390-522
Range on HMM: 27-159/164.0
EHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQ
...|||   .| | . |..  . ||.||..|  . || ..|| .|.| |  ...| .. . .  ... |   | .||||| .|.|||.|| .|. .|  .
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

WEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM
| ...| |..|.|||...||. || || ..  .
wtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_STYXL1_pd Subfamily STYXL1 390-520 1.5e-24 80.0 In-house 17-150 (157) alignment 
Range on Protein: 390-520
Range on HMM: 17-150/157.0
EHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFE---YFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMK
...||| . .| | .  .   |.  .||. . |... |. .    ....| |.....||.  ..  ..| . | ||. |||  . |.||||.|.||| | 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

AYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYS
 .......|....|| .. .|||..|..||. . 
skkitlkkaykylkkCkenvkPnrafveqlseWe
0051429 (Phosphotyrosine protein) phosphatases II 390-519 3.3e-18 61.8 In-house 21-220 (272) alignment 
Range on Protein: 390-519
Range on HMM: 21-220/272.0
EH-VYLGSEW---NASNLEELQKNGVRHILNVTREIDNFFPG------TFEYFNVRVYDDEKTNLL----------------------------------
.. .|... .   .| ... |...|...|.....|    . .       ..|... ..||. .  |                                  
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------KYWDDTFRYITRakaeGSKVLVHCKMGVSRSASVVIAYAMKaYQWE--------------FQQALEHVKKRRSCIKPNKNFLN
                 ..  . .... .    | .|||||. |..|.. || .. .  ....               ..|.|.....| .. ..  .. 
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLETY
.|  .
flyea
subfamily_MSG5_pd Subfamily MSG5 390-526 1.8e-17 57.0 In-house 32-163 (165) alignment 
Range on Protein: 390-526
Range on HMM: 32-163/165.0
EHVYLGSEwnaSNLEELQKNGVrhILNVTREIDNF--FPGTFEYFNVRVYDDEKtnLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKA
|..|| ||    .|.||    .  ..||..||...     . .|. ..   | |  . |      | |  |.... |.||||. |.|||||...|| || 
eklylyse...pklkellsfdl..vinvakeindlellvpavkyyhiewehdsk..ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimky

YQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAM
|.  ...| ...| .   |.|.  .. ||  .  .|.. 
ynlslrdaydklksvaddispsiglifqlmewevalskk
DSPc Dual specificity phosphatase, catalytic domain 392-519 7.7e-37 121.1 Pfam-A 1-130 (133) alignment 
Range on Protein: 392-519
Range on HMM: 1-130/133.0
VYLGSEWNASnLEELQKNGVRHILNVTREIDN---FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAY
.||||. .|| |. |.|.|. ...|||.|..|   . .. .||... | |...|.. |. ... ..| .|...| ||||||..|.||||...||| || .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QWEFQQALEHVKKRRSCIKPNKNFLNQLETY
... ..|.|.||.|||.| || .|| ||  |
nlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 392-519 7.7e-37 121.1 In-house 1-130 (133) alignment 
Range on Protein: 392-519
Range on HMM: 1-130/133.0
VYLGSEWNASnLEELQKNGVRHILNVTREIDN---FFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAY
.||||. .|| |. |.|.|. ...|||.|..|   . .. .||... | |...|.. |. ... ..| .|...| ||||||..|.||||...||| || .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QWEFQQALEHVKKRRSCIKPNKNFLNQLETY
... ..|.|.||.|||.| || .|| ||  |
nlslneAyefvkerrskispnagflrqLley
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 392-517 1.9e-14 47.0 In-house 6-135 (145) alignment 
Range on Protein: 392-517
Range on HMM: 6-135/145.0
VYLGSEWNASNLEELQKNGVRHILNVTRE----IDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKA
.| ||  .|...  ||. |.  |.|..       ..     .| . .   | |  .| ...|.   .| . | ||. |.|||  ||||| .| .|. || 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

YQWEFQQALEHVKKRRSCIKPNKNFLNQLE
 .  . .|   |. .|    || .||..| 
cnmtlseaarqvrsnrllaypnvtflknll
0045450 (Phosphotyrosine protein) phosphatases II 399-519 3.5e-23 78.2 In-house 88-299 (307) alignment 
Range on Protein: 399-519
Range on HMM: 88-299/307.0
NASNL--------------------------------EELQKNGVRHILNVTREIDN-------FF---------------------PGTFEYFNVRVYD
|||                                  . |...||..|...|.....       ..                      . . .....| |
NAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtd

D-----------------EKTNLLKYWDDTFRYITRAKA------EGSKVLVHCKMGVSRSASVVIAYAMKAYQ--------WEFQQALEHVKKRRSCIK
                    ... ........ | ....      .|..|||||..||.|......|| |. .         . ...|.......|... 
ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

PNKNFLNQLETY
.| ... .|  .
qnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 403-519 1.2e-21 72.7 In-house 103-271 (317) alignment 
Range on Protein: 403-519
Range on HMM: 103-271/317.0
LEELQKNGVRHILNVTREIDN---------------------------FFPGTFEYFNVRVYDD----------------EKTNLLKYWDDTFRYITRAK
.. ....||..|...|.. ..                           .  . .......|.|.                   .. ...|. .. . ...
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

AE----GSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY
.     |..|||||..||.|......|| |     | ... ...|.......|... .. ... .| ..
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0039614 (Phosphotyrosine protein) phosphatases II 403-519 4.1e-19 64.6 In-house 118-284 (297) alignment 
Range on Protein: 403-519
Range on HMM: 118-284/297.0
LEELQKNGVRHILNVTREIDNFFpG----------TFEYFNVRV---------------------------------YDDEKTNLLKYWDDTFRYITRAK
.. ....||..|...|.....              |.. | |..                                  |.   ..|.. .. .... .| 
wrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreal

A---EGSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETY
|   .| .|||||..||.|......|| |     | ... ...|.......|... .. ... .|  .
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 404-518 1.3e-15 53.0 In-house 106-271 (278) alignment 
Range on Protein: 404-518
Range on HMM: 106-271/278.0
EELQKNGVRHILNVTREIDNFFPGTFEYFN-----------------------------------------------VRvyDDEKT-NLLKYWDDTFRYI
. ....||..|...|.. ..  .. ..|..                                               .   |..   .|  ..|   . .
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavr

TRAKAEGSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPNKNFLNQLET
.. . ....|||||. ||.|.. ....| .     | . . ...|.......| .. .. ... .|  
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
subfamily_DSP23_pd Subfamily DSP23 405-504 4.9e-06 21.3 In-house 26-126 (148) alignment 
Range on Protein: 405-504
Range on HMM: 26-126/148.0
ELQKNGVRHILNVTREIDNFFPGTFEYFNVRV-YDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRR
 |  .|||... .| |       | .   ||.  || .   |.  ..  | .  |.. .  | ||| .|  |. ...  | .|  .    .|.  |...|
ylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr

S
 
p
0047943 (Phosphotyrosine protein) phosphatases II 406-516 3.8e-12 41.7 In-house 97-264 (273) alignment 
Range on Protein: 406-516
Range on HMM: 97-264/273.0
LQKNGVRHILNVTREIDNFFPGTFEYFNVRVYD----------------------------------------------DEKTNLLKYWDDTFRYITRAK
. ...||.|  .|.....  .  . |.   . .                                                  .   .... ...|  ..
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

A------EGSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPNKNFLNQL
       ....|.|||. ||.|........ .     | ... . .|. .....| .. .. ... .|
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 407-508 1.4e-10 36.5 In-house 129-283 (308) alignment 
Range on Protein: 407-508
Range on HMM: 129-283/308.0
QKNGVRHILNVTREIDNFFPGTFEYF------NVRVYDDEKT----------------------------------------NLLKYWDDTFRYITRAKA
 ...||.|  .|....|  .  ..|.      ....|.. .                                         .   .... .... ... 
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

E--GSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKP
   |....|||. ||.|.. ..... .     | . . ...|. .....| .  .
slpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0051299 (Phosphotyrosine protein) phosphatases II 407-510 1.7e-10 36.3 In-house 113-272 (288) alignment 
Range on Protein: 407-510
Range on HMM: 113-272/288.0
QKNGVRHILNVTREIDNFFPGTFEYFN---------------------------VRVYDD--------------------EKTNLLKYWDDTFRYITRAK
 ...||.|  .|.....     . |..                           ..| .                        .   .... .... ...
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

AE----GSKVLVHCKMGVSRSASVVIAYAM-----KAYQWEFQQALEHVKKRRSCIKPNK
      |. |.|||. ||.|.. ..... .     | . ... .|.......| .. .. 
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 408-506 1.4e-09 33.2 In-house 99-256 (284) alignment 
Range on Protein: 408-506
Range on HMM: 99-256/284.0
KNGVRHILNVTREIDNFFPGTFEYFNVRvyD------------------------------D------------------------EKTNLLKYWDDTFR
...||.|  .|....|     . |..    .                                                       . ..||.....  .
eqnvrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

YITRaKAEGSKVLVHCKMGVSRSASVVIAYAMKAY--------QWEFQQALEHVKKRRSCI
....    |....|||. ||.|.. ..... .. .         . ...|. .....| . 
llen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
subfamily_PTPMT1_pd Subfamily PTPMT1 410-521 2.7e-17 57.7 In-house 58-166 (171) alignment 
Range on Protein: 410-521
Range on HMM: 58-166/171.0
GVRHILNVTREIDNFfpgTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPN
 .... | |.|  .      |...... |  ..  |.   .. ..|.. . .|..| |||| | .|||..|..| || .... ..||...||.|. |. .
elkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirla

KNFLNQLETYSG
|. ...|. |  
kkqwkalqeyee
0048567 (Phosphotyrosine protein) phosphatases II 424-520 7.1e-08 27.0 In-house 10-135 (157) alignment 
Range on Protein: 424-520
Range on HMM: 10-135/157.0
FFPGTFEYFNVRVYDDEKTNLLKY-WDDTFRYITRAK-------------------------AEGSKVLVHCKMGV---SRSASVVIAYAMKAYQWEFQQ
. |... ..... ...   |.| . .||.. |..                             .| .. ||||.|    .|.| .. .|... ...  ..
iipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpee

ALEHVKKRRSCIKPNKNFLNQLETYS
|.....  |  ..|     . | .|.
aiaplrivrpgsvpfrdasyllslyn
subfamily_PTPDC1_pd Subfamily PTPDC1 438-522 3.7e-06 21.5 In-house 91-174 (182) alignment 
Range on Protein: 438-522
Range on HMM: 91-174/182.0
DDEKTNLLKYWDDTFRYITRAKAEGsKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGM
.| ... |.   |  . .. |  || || |||  |  |   .. .| . | . . ..|.. |...|.     .. .. .. .. .
kDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalf
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 446-498 1.6e-06 20.9 In-house 49-102 (128) alignment 
Range on Protein: 446-498
Range on HMM: 49-102/128.0
KYWDDTFRYITRAKAEGSKVL-VHCKMGVSRSASVVIAYAMKAYQWEFQQALEH
 |    .| |  .. |   || |||. |. |.  |. .|.||   .....||| 
pyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 446-498 1.6e-06 20.9 In-house 48-101 (128) alignment 
Range on Protein: 446-498
Range on HMM: 48-101/128.0
KYWDDTFRYITRAKAEGSKVL-VHCKMGVSRSASVVIAYAMKAYQWEFQQALEH
 |    .| |  .. |   || |||. |. |.  |. .|.||   .....||| 
pyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_RNGTT_pd Subfamily RNGTT 459-517 4.6e-06 20.4 In-house 110-168 (189) alignment 
Range on Protein: 459-517
Range on HMM: 110-168/189.0
KAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLE
|   . . |||. |  |.  ....| ..  .|. ..|..  .| |     ....|..| 
knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkell