Gene EDTP in Drosophila melanogaster

Synonym: BcDNA:LD16029, CG9554, CLI, CLIFT, Dmel\CG9554, EY2-1, EYA, Eya, cli, cli/eya, dEYA, del1, eay, ey-2, Dmel_CG9554, eya

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP029_AA protein Get Run
DmelP029_AA_341-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0040695 (Phosphotyrosine protein) phosphatases II 35-574 5.2e-62 203.7 In-house 5-384 (388) alignment 
Range on Protein: 35-574
Range on HMM: 5-384/388.0
EEGTAEYDISKKCEYL-FKLDYSLIELDNTNGLLSPRYPGRILipeyehghmaktlvpgnglfgqvgggvggggssgttatatplnssagstgsegvgiq
|||. .||| .....| ..||.  |   | |. |.|.||....                                                         
eegwslydilrelkrlglgldlwrisivNenyelcpsYPallv.........................................................

afvtfanplqtqqqhplqqqypsqqmhplhaqypsqqphplqqqqqqpsqqqpqntiyedqydIQRMRELVTMAKYARCRQRFAVPVIMY----RGKYIC
                                                               .... .  .....||.|... .||..|    .|....
...............................................................VPksisdellkrvarfrskgriPvlsyrhpnngavll

RSATLSVmpetygrkvvdyaydclsggnytapngeendadstdeslithmHDQAQSQFSYDEVIKSDIQLLHTLNVSTIVDLMvenRKIKYFMAVSSSEK
||... |                                           . . ...............||..|.. .||||.   .|....... ....
Rssqplv...........................................glllsrsledeklleailkllpnlskllivdlr...pklnalanralggg

ADPNKHYKSFNLLSLPYPGCEFFKKfrdnnymarnlhynWKQTFNDANINIPNMGpaaDIDVAWSEYRDWDLVAITQNYLRATLKYVQEENSGLLIHCIS
 .. ..|....|..|..|.......              . |.. ||..|.|..    .. ....|.. .||. ......  ..|... .||..|.||..
venedaypnaeliflnipnihvvre..............slqklldaclnvpdsl...nllslleesgwldliklilelavlivklldlgnssvlvhcsd

GWDRTPLFVSLVRLSLWADgliHQSLNAMQMAyftLAYDWYLFGHQLPDRLKRGED---------------------------IMFFCFHVLKFITDEEF
|||||....||..|.|...   ...|. .|.    ....|..|||...|||...|.                           ...|....|.|..|. .
gwdrtsqlssLaqllldPy...YRTleGFqvL...iekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhly

SIV--------EHRKRTKTSSSSGSSVIVIKSDCCDDeplkdpftlncrDYILSFDQDSN-DSYSNCSNCDMSITDNFYAT
| .        |..... . |....|.. .   ....             . ...|..|.   . ..|..|. . ...| .
scrfgtFlfnsekerlelsvsertlslwsyllsrkse............flnplYdpsslevllpslsvldlllWleyylr
subfamily_MTMR14_pd Subfamily MTMR14 45-509 1.1e-193 634.9 In-house 1-357 (357) alignment 
Range on Protein: 45-509
Range on HMM: 1-357/357.0
KKCEYLFKLDYSLIELDNTNGLLSPRYPGRILIPEYEHGhmaktlvpgnglfgqvgggvggggssgttatatplnssA---Gstgsegvgiqafvtfanp
||.|.|.| ||||...||||| |..|||...||.|||.|                                      .   |                  
kkveellkrdyslsvidntnGelcsrypvkllileyelg......................................egseg..................

lqtqqqhplqqqypsqqmhplhaqypsqqphplqqqqqqpsqqqpQNTIYEDQYDIQRMRELVTMAKYARCRQRFAVPVIMYRGKYICRSATLSVMPETY
                                             .....|..||.||.|||.|.|||||||.||.||||...||.|||||||||..|.|
.............................................ekelvesaydvqrlrelltkakyarcrerfvvpvilldgknicrsatlsvaaeiy

GRkvvdyaydclSGGNYTAPNGEENDADSTDESLITHMHDQAQSQFSYDEVIKSDIQLLHTLNVSTIVDLMVENRKIKYFMAVSSSEKADPNKHYKSFNL
||          || ||.|..|||.|||..||.|||...|||..|...|.|.||||.||.||.|..|||||||..|.||..|||||||||..|.||.|.|
gr..........sGlnylasggeeadadkedeelitakedqaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftl

LSLPYPGCEFFKKFRDNNYMARNLHYNWKQTFNDANINIPNMgPAADIDVAWSEYRDWDLVAITQNYLRATLKYVQEEN-SGLLIHCISGWDRTPLFVSL
|||||||.|||||||||.|.|.||.|||||...||..|||.. .||..|..||||..|||||.|||||...||||.|.. ||||.|||||||||||||||
lslPyPGveffkkfrdnkysaknlfynWkqdevdaelniPdk.laasvdidwseykkWdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsl

VRLSLWADGLIHQSLNAMQMAYFTLAYDWYLFGHQLPDRLKRGEDIMFFCFHVLKFITDEEFSIVEHRK
.||||||||||||||.|....|.|.||||.|||||||||||.||.|.||||.||||||.|||||.|.||
lrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsiletrk
YppG YppG-like protein 139-202 2.9e-06 14.4 Pfam-A 22-88 (112) alignment 
Range on Protein: 139-202
Range on HMM: 22-88/112.0
ANPLQTQ-QQHPLQQQYPSQQMHPLHAQYPsqQPHPLQQQQQ-QPSQQQP---QNTIYEDQYDIQRMRE
 .. |.| |. . .... .||...   ..|  .| | |..|| |||. .    | .  . ..|...| .
qqqpqqqqqpeeassppqkqqaneappkap..nPyPkqspqqqqpskfssilsqFknedGnfDfnKmmn
Myotub-related Myotubularin-like phosphatase domain 208-527 1.3e-07 23.8 Pfam-A 73-307 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 208-527 1.3e-07 23.8 In-house 73-307 (353) alignment
0037934 (Phosphotyrosine protein) phosphatases II 284-445 2.9e-06 22.5 In-house 48-203 (243) alignment 
Range on Protein: 284-445
Range on HMM: 48-203/243.0
QSQFSYDEVIKS----DIQLLHTLNVSTIVDLMVEN--RKIKYFMAVSssekadP-NkHYKSFNLLslpypgceFFKKFRDNNYMARNLHYNWKQTFNDA
 .|.  .| ...    ....|. |....||.|. .    ..|...  .          .|. |           . .    ..|. |.|.. .... .  
atqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp......gev.tygdftvt........llseehlddytvrtlllenldlddlt

ninipnmgpAADIDVAWSEYRD---WDLVAITQNYLRATLKY--------VQEENSGLLIHCISGWDRTPLFVSLVRLSL
           .| . .    |    | ... ...|... ..        .  ... .|.||  | .|| ... .  . |
.........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll
0043147 (Phosphotyrosine protein) phosphatases II 286-441 7.3e-08 27.8 In-house 26-121 (172) alignment 
Range on Protein: 286-441
Range on HMM: 26-121/172.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMvENrkikyfmavsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndanINIPNMGP
|. ... . .....|..|....||.|. |                                                                ..|    
qgplrntladfwrmlkelgithivnlt.el..............................................................lydpelle

AADIDVAWSEYRDWDLVaiTQNYLRATLKYVQE-----ENSGLLIHCISGWDRTPLFVSLV
  .| . .  . | .    . ..|. .|....|     ..   |.||  |..||...| . 
rlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaay
0040439 (Phosphotyrosine protein) phosphatases II 286-443 1.2e-07 27.1 In-house 60-202 (249) alignment 
Range on Protein: 286-443
Range on HMM: 60-202/249.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMVENRK--IKyfmavsssekadpnkhyksfnlLSLPYPGcEFFKKFrdNNYMARNLHYNWKQTFNDANINIPNM
|.  .| .......|. |....||.|. . ..  .|                          .|  . ....  .... ..|....|. .   .. . |.
qgPlpetvedfwrmlwelgitvivmLtslvelgrek......................caqywpl.ggsley..gdftvtllsvevkddytvrtleltnl

GPAADIDVAWSEYRDWDLVAIT--QNYLRATLKYVQE------ENSGLLIHCISGWDRTPLFVSLVRL
.   .. | .  | ||    .    . | . ...|..      ... .|.||  | .||..|. .  .
ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
0049260 (Phosphotyrosine protein) phosphatases II 286-441 1.4e-07 26.8 In-house 15-110 (152) alignment 
Range on Protein: 286-441
Range on HMM: 15-110/152.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMVENRKIKYFMAVSSsekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipnmgp
|. ... .......|..|...||| |. .  . |....                                                              
qgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................................

aADIDVAWSEYRDWDLVAITQNYLRATLKYVQEENSGLLIHCISGWDRTPLFVSLV
   . . |  .  .||  . .  |..  |. ....   |.||  | .||...| . 
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay
0042113 (Phosphotyrosine protein) phosphatases II 286-443 1.9e-06 23.0 In-house 58-199 (245) alignment 
Range on Protein: 286-443
Range on HMM: 58-199/245.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMVENRK--IKyfmavsssekadpnkhyksfnllS-----LpyPGCEFFkkfrdNNYMARNLHYNWKQTFNDANI
|.  .| ..  ...|. |...|||.|. |  .  .|                       .     |   .   .     .... ..| .......   ..
qgPlpetvedfwrmlwelgittivmLteeeelgrvk.......................caqywpl..geslty.....gdftvtllseehlddytvrtl

NIPNMGPAADIDVAWSEYRDWD------LVAITQNYLRATLKYVQ-EENSGLLIHCISGWDRTPLFVSLVRL
.. |.|      |    | .|.      |... .. |.. .|...  .|  .|.||  | .|| .|. . ..
evtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm
0045098 (Phosphotyrosine protein) phosphatases II 290-443 3.2e-08 28.8 In-house 74-229 (278) alignment 
Range on Protein: 290-443
Range on HMM: 74-229/278.0
DEVIKSDIQLLHTLNVSTIVDLM--VENRKIKYFMAVSSsekadpnKHYKSFNLLSLPYPGCEFFkkfrdNNYMARNLHYNWK----QTFNDANINIPNM
.. . .....|. |....|| |.  ||. ..|...   .       .... .. ... .  .| .     ..|  | |..       ...  ..... ..
pstvadfwrmlwelgitvivmltelvelgrekcaqywpe.......ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhy

GPAADIDVAWSE--YRDWDLVAITQNYLRATLKYV------QEENSGLLIHCISGWDRTPLFVSLVRL
 |  | .|  ..     ..|.   ...|.. ....      ....   |.||  |..||  .| .  .
lpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm
0041856 (Phosphotyrosine protein) phosphatases II 291-441 7.8e-07 24.3 In-house 45-130 (182) alignment 
Range on Protein: 291-441
Range on HMM: 45-130/182.0
EVIKSDIQLLHTLNVSTIVDLMvenrKIKYFMavsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipNMGPAADID
. . .....|. |...|||.|        |.                                                            .  . . | 
stvadflrmlkelgittivnlt....eelywp...........................................................ellerlgiq

VAWSEYRDWDLVAitQNYLRATLKYVQEENSGLLIHCISGWDRTPLFVSLV
. .    |..      . | . .. |.||.   |.||  | .||. .| . 
ylylpwpDhgvpd..ldelldfieevleeggpvlVHCsaGvgRtgtlvaay
0048179 (Phosphotyrosine protein) phosphatases II 293-443 3.9e-06 22.2 In-house 18-106 (144) alignment 
Range on Protein: 293-443
Range on HMM: 18-106/144.0
IKSDIQLLHTLNVSTIVDLMVENRKIKYFMAvsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhyN------------------------
  .|..||. |...|...|. |  .  .                                               .                        
taldlellkklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllelllefl

-----WkqtfndaninipnmgpaadidvawseyrdwdlvaitqnylratlkyvQEENSGLLIHCISGWDRTPLFVSLVRL
     .                                               .||.   |.||  | .||...| . ..
efieea...............................................leeggpvlVHCsaGvgRtgtlvaaylm
0048076 (Phosphotyrosine protein) phosphatases II 293-443 9.9e-06 20.8 In-house 18-104 (145) alignment 
Range on Protein: 293-443
Range on HMM: 18-104/145.0
IKSDIQLLHTLNVSTIVDLmvenrkikyfmavsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndanINIPNMGPAADIDVA
  .|..||. |.. |...|                                                                   . ..   . .| . 
taldlellkdlgittvlnl..................................................................tselellerlgiqyl

WSEYRDWDLVAITqNYLRATLKY---VQEENSGLLIHCISGWDRTPLFVSLVRL
.    |..   .. ..|.. |..   ...|.   |.||  | .||...| .  .
ylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm
0044763 (Phosphotyrosine protein) phosphatases II 294-440 2.9e-08 29.0 In-house 38-130 (178) alignment 
Range on Protein: 294-440
Range on HMM: 38-130/178.0
KSDIQLLHTLNVSTIVDLMVENRKIKYFMAV------SssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipnmgpAA
 .|..||. |....||.|  | .  .. .        .                                                              
addlellkelgithivnlteelelgflkcdpywpeeag............................................................iq

DIDVAWSEYRDWDLVAITQNYLRATLKYVQEENSGLLIHCISGWDRTPLFVSL
 . . .. . . || ..... ...  ....|...  |.||  |..|....| .
ylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaa
0051429 (Phosphotyrosine protein) phosphatases II 295-454 1e-12 43.8 In-house 36-200 (272) alignment 
Range on Protein: 295-454
Range on HMM: 36-200/272.0
SDIQLLHTLNVSTIVDLMVEN--RKIKYFMAVsssekadPNKHYKSFNLLSLPYPGCEFFKKFRDNNYMARNLHYNwkqtfNDANINIPNMGPAADIDVA
 |.. |..|...|||||. |.   . |...         |. .|  ...|.  .|  .... .  . ..   |.|       .  . .  ... .   | 
adfwrlkelgiktivdLrseeErgrlkcdryw.......pgirylhlpilddsaptilygalrvtllseellldyi.....lrellltlllsagearevm

WSEYRDWDLVAITQNYLRATLKYVQEeNSGLLIHCISGWDRTPLFVSLVRLSLWAD----------------GLIHQS
.  |.||    . |..|.. |..... .  .|.|| .|.||| ..| |..| |  .                . ... 
hlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel
0051082 (Phosphotyrosine protein) phosphatases II 295-444 3.5e-10 35.2 In-house 24-116 (151) alignment 
Range on Protein: 295-444
Range on HMM: 24-116/151.0
SDIQLLHTLNVSTIVDLMVENRKI---KYFMAVSssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipnmgpaadIDV
 ...||..|...|||.|. |       .|. . .                                                               |.|
dflellkelgiktivnlrseeergycpeylpelg...............................................................iev

AWSEYRDWDLVAI--TQNYLRATLKYVQEE-NSGLLIHCISGWDRTPLFVSLVRLS
 .  . ||.   .  ... ... |.....  |  .|.|| .|..|| ..| |... 
lhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
0049772 (Phosphotyrosine protein) phosphatases II 392-446 1.6e-06 23.6 In-house 187-240 (314) alignment 
Range on Protein: 392-446
Range on HMM: 187-240/314.0
AWSEyRDWDlvaiTQNYLRATLKYVQE--ENSGLLIHCISGWDRTP--LFVSLVRLSLW
 ..   ...    . ..... |....|  ... .|.|| .|..||.  ... .. . |.
pvpD.gsap....lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 403-521 5.5e-08 24.4 In-house 206-290 (404) alignment 
Range on Protein: 403-521
Range on HMM: 206-290/404.0
AITQNYlRATLKYVQEENSGLLIHCISGWDRTPLFVSLVRLslWADGlIHQSLNAMQMayfTLAYDWYLFGHQLPDRLKRgedimffcfhvlkfitdeef
 . ..     .. ...|.|  |.||. |||||.  .||..|   .|   .. ... ..    .  .|  |||   .| ..                    
lllegs.kriveliekekssvlvhcsdgwDrtsqlsslsql..lldp.yyrtiegFiv...liekewlsfGhkfaqRigq....................

sivehrkRTKTSSSSGSSV
       .|..||.  | .
.......ttekssdersPi
subfamily_MTMR3_pd Subfamily MTMR3 414-485 8.2e-09 27.7 In-house 263-328 (442) alignment 
Range on Protein: 414-485
Range on HMM: 263-328/442.0
KYVQEENSGLLIHCISGWDRTPLFVSLVRLSLwaDGlIHQSLNAMQMayfTLAYDWYLFGHQLPDRLKRGED
. |..|.  .|.||  |||||.  |.| .| |  |   ...|. ...    .  .|  |||.. ||   ||.
eavdkegrpvlvhCsdGWdrttqivalaklll..dp.yyrtleGfkv...lvereWldfGhkfadrcghgen
subfamily_MTMR1_pd Subfamily MTMR1 414-485 5.7e-08 24.4 In-house 206-271 (389) alignment 
Range on Protein: 414-485
Range on HMM: 206-271/389.0
KYVQEENSGLLIHCISGWDRTPLFVSLVRLSLwaDGlIHQSLNAMQMayfTLAYDWYLFGHQLPDRLKRGED
. |..|..  |.||  |||||  ..||  | |  |   ..... ...    .. .|  |||.. .|| .|..
ekvetektsvlvhcsdGWDRtaqltsLamlll..Ds.yyRtieGfev...liekeWlsfGHkfkeRlghgdk
subfamily_MTMR6_pd Subfamily MTMR6 414-479 3e-06 18.8 In-house 217-276 (397) alignment 
Range on Protein: 414-479
Range on HMM: 217-276/397.0
KYVQEENSGLLIHCISGWDRTPLFVSLVRLslwadgLIHQSLNAMQMAYFTLAYDWYLFGHQLPDR
|.|.||.   |.||  |||||   .||  |      |. .   ...     .  .|  |||.. .|
kavaeegasvlvhcsdGwdrtaqvcslasl......lldpyyrtikGflvliekewlsfGhkfser