Gene Sbf in Drosophila melanogaster

Synonym: CG6939, DSbf1, Dmel\CG6939, SBF, Sbf1, dSbf1, sbf, Dmel_CG6939, Sbf

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR5
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP031_AA protein Get Run
DmelP031_AA_1152-1675 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
uDENN uDENN domain 31-91 1.7e-21 65.4 Pfam-A 2-64 (65) alignment 
Range on Protein: 31-91
Range on HMM: 2-64/65.0
GKIVQRFPEKDW-PDTPFIEGIEWFCQPLGWSLSYEK-QEPKFFVSVLTDIDANKHYCACLSF
.|| ..|||||. .|.|. . |..||.| |... ... |.|.||. ||||.| ...|..|| |
pkildqfPekdeeedeplpkaipmFCfPeglnfvtsreqkpeffsfvLTdedgsriyGfClrf
DENN DENN (AEX-3) domain 142-324 8.4e-62 197.7 Pfam-A 1-184 (185) alignment 
Range on Protein: 142-324
Range on HMM: 1-184/185.0
YAPKCLVLISRLDCAETFKNCLGTIYTVYIENLAYGLETLIGNILGCIQVPPAGGPQVRFSIGAGDKQSLQPPQSSSLPTTGSGVHFLFKQLGIKNVLIL
..||.|...|||.. |.||..| ...... ..    ||..| |.| ....|..| ... .| .. .|..|| |.||.||.... .. ||..|.|.||| |
ripkalcilsrlpffelfkkiLkalekrlksssklplesfianlllevplPapgktlklkslsvkekillqrpssselPledvdleelfrcLsienvlql

LCSVMTENKILFLSKCYWHLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQT-EITDLLDVIVVDLDG
...|..|..|..||. .. ||. ..|||||.||....|.|||.||| |..||..|||||.|..|||.. | ..| ||..|||| 
feavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslleleekpledvvlvDldt
dDENN dDENN domain 383-452 1.4e-19 59.2 Pfam-A 1-68 (68) alignment 
Range on Protein: 383-452
Range on HMM: 1-68/68.0
IDKELRAIFMRLFAQLLQGYRSCLTIIRIHPKpvITFHKAGFLGARDLIESEFLFRVLDSMFFTTFVNER
.|...|..|.|.||.||.|||..|...| .|.  ..|.|..|| .|.  ...|| ..|....|..|. ||
ldqqvreaFlrffasllggYrnflrkerkspe..vsFqkeaFlksrskshrsFlsqfletqmFaeFieer
SBF2 Myotubularin protein 582-807 6.7e-100 322.3 Pfam-A 1-225 (225) alignment 
Range on Protein: 582-807
Range on HMM: 1-225/225.0
PMGPRLPEALDVRPNVQ-NSARRLEVLRICVSYIFENRITDARKLLPAVMRTLMHRDARLILCREFFGYVHGNKAVLDHQQFELVVRFMNKALQKSSGID
|.||.. .... . ... |||||||||| |.||||.|.|..|.|.||||.|.| ...|||.||.|.  .|..|.||||||||.||||.||||||..|  |
pagptvasivektkstvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakd

EYTVAAALLPMSTIFCRKLSTGVVQFAYTEIQDHAIWKNLQFWESTFFQDVQGQIKALYLLhrRQNEHQKEANCVLDEVPLEEPTALEITAEQLRKSPNI
||.|||||||.|..||||||.||.||||| .||| .||| ||||.||.|.|| .||.|||   ...|..|....  ...  ||..||||.|.||||.|..
eygvaaallplssafcRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelyle..kkseskkkkktesslskkeeksaleiaadqlrkwptl

EEEKKAELAKSEESTLYSQAIHFANRM
..||..||.|.||||.||||||||||.
skekqkelvkkeestvysqaihfanrl
GRAM GRAM domain 923-1001 5.4e-17 52.5 Pfam-A 2-68 (69) alignment 
Range on Protein: 923-1001
Range on HMM: 2-68/69.0
KIQTPCLLPGEDLVTDHLRCFLMPDgredetqcLIPAEGALFLTNYRVIFKGSPCDPLFceqvIVRTFPIASLLKEKKI
|..... ||.|. . |...| |...        ..|..|.|.|||||.||.....|...    .|...|.|.. . .|.
kfrktfklppeEkllddyaCylsts........kgpvqGrlYlTnyrliFrSdklddsk....vvvvipladikrveks
Myotub-related Myotubularin-like phosphatase domain 1137-1568 9.4e-117 382.7 Pfam-A 2-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1137-1568 9.4e-117 382.7 In-house 2-352 (353) alignment
subfamily_MTMR5_pd Subfamily MTMR5 1154-1671 4.9e-226 743.1 In-house 2-483 (483) alignment 
Range on Protein: 1154-1671
Range on HMM: 2-483/483.0
VERMRERSYVQDWKRLGFDAE---SQRG-FRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHA-NGALLIRGGQPNSKSVIGM
||...||.||||.||||..|.   |.|| ||||..|..|..||||||.||.|...||..|.....||. .|.|..||||. |.|||||.|...||.|.|.
veklaerayvqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgl

LK--NTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNqySGMNLSMSSLMGHSSSDDRQPLTPElsrkhKNNLDISDGNKSSQGGKGGTM-KGN
||  ||.||.|..........||.||. |..|...||..||||  |....|.|.|...||||.|..|..|     ||.||||...|.||||||.|. ..|
lksantqgsstsessessksleqekylkavvnevsklsalaln..sslevslsvlasssssdkraalste.....knaldisksdkasqggkgatlkenn

PKNSLAHPFRKMRLYALGEKSQAKS-NMNVDFCADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLID
.|.| ....||..||.||||||.|. ...||..|.||||....|||....||||.|||.||....||. |||.|.||.|.||||||||.|||||||||.|
akeskklrarkaaLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlld

LQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTniAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLR
||.|||..|||||.|||||.||.|||.||||||.|.||.||||||||||||||..|||...|....  .|||.||||||.|||..||||.|||||||||.
lqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqss..gfaPvFlqFLDcvhqvsrqfPlafefndfylk

FLAYHSVSCRFRTFLFDCELERSDSGIaamedkrgslnakhmfgaggmatngsddecsvypldIRSQRAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYS
||||||||.||||||.|.|.||..||.                                    .....|... ...|.|..|||.|||...|||||||||
flayhsvsnrfrtfllDseyerlesgl....................................lyeekaekrakkagksvwdyidrqhkrspifynflys

GDKSVTLRPQNNVAALDLWCYYTNEEL
.|.|..|||..||..|..|.||..|||
pdesevlrPssnvsslkvWdyyleeel
subfamily_MTMR3_pd Subfamily MTMR3 1155-1241 3.4e-15 48.7 In-house 22-107 (442) alignment 
Range on Protein: 1155-1241
Range on HMM: 22-107/442.0
ERMRERSYVQDWKRLGFDaeSQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHA-NGALLIRGGQPN
... | .. .. .|||||   .  .|||..|...  |.|||  .. |.. .| .. .  .    .|.|   |||  |||.|.| .||.
asvaeeklkeeverlGfd..lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPe
0040695 (Phosphotyrosine protein) phosphatases II 1157-1669 6e-107 351.6 In-house 8-384 (388) alignment 
Range on Protein: 1157-1669
Range on HMM: 8-384/388.0
MRERSYVQDWKRLGFDAEsqrGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHA-NGALLIRGGQPNSksvigmlknttgs
. ........||||.. .    .|||. |  |  |.||||..| |...||  ...  |.....|||  ..||. |||.|.| .|| .             
wslydilrelkrlglgld...lwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv.............

ttnaHHDVTHYPEQDKYFLALINTMPkltplalnqysgmnlsmsslmghsssddrqpltpelsrkhknnldisdgnkssqggkggtmkGNPKNSLAHPFR
    .. .. . |..|.. |.....|                                                              ...|. .    .
....glllsrsledeklleailkllp..............................................................nlskllivdlrp

KMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACmpshnTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLE
|.. .|   ..    |..  ..|..|....|.|.. | ...||..||     .|  | ... ...|.|.||..|.....|.  .|.|.||..|||..  .
klnalanralgggvenedaypnaeliflnipnihvvreslqklldac.....lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcs

DGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNiAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRF
|| | |.||||.|||.||||||.|.||.||.|||||.|||.||.|... .|. ...  |.|.||.|||.|.||.||||.|||||...|.|||.|..||||
dgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidsk.efsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrf

RTFLFDCELERSDSGIaamedkrgslnakhmfgaggmatngsddecsvypldirsqrapaplNRIGHSIFDYIERQHNKtpiFYNFLYSGDKSVTLRPQN
.||||..| || ....                                              .. ..|...|. .....   |.|.||. .... |.|  
gtFlfnsekerlelsv..............................................sertlslwsyllsrkse...flnplYdpsslevllpsl

NVAALDLWCYYTNE
.|  | ||..|...
svldlllWleyylr
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1164-1241 3.7e-14 44.7 In-house 23-99 (404) alignment 
Range on Protein: 1164-1241
Range on HMM: 23-99/404.0
QDWKRLGFDAESqrGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHA-NGALLIRGGQPN
...||||. .||   .|||..|. |  | .|| ..| | ..||  . .     . .|||  .|||  ... ..|  || 
eEykRlgikses..eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqpl
subfamily_MTMR1_pd Subfamily MTMR1 1164-1242 8.3e-10 30.5 In-house 14-91 (389) alignment 
Range on Protein: 1164-1242
Range on HMM: 14-91/389.0
QDWKRLGFDAESqrGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHAN-GALLIRGGQPNS
.. .|||   |    .||.. |..|. | .|||..| | ..||  . . ..  . .|.|  .| . . .| ..|  ||..
aelerlgllnek..lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplv
subfamily_MTMR9_pd Subfamily MTMR9 1167-1244 2.1e-12 38.8 In-house 29-100 (393) alignment 
Range on Protein: 1167-1244
Range on HMM: 29-100/393.0
KrlgfdaeSQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH-ANGALLIRGGQPNSKS
        .. ..|||. |  .. | |||. .. | . .| ..    .  .| |.|. ...| ...| |.| .|| . |
s.......asdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgs
subfamily_MTMR10_pd Subfamily MTMR10 1172-1240 8e-08 23.4 In-house 19-87 (380) alignment 
Range on Protein: 1172-1240
Range on HMM: 19-87/380.0
DAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANGALLIRGGQP
. ....... .. |   |.. ..|  .| | ..||  .  | | .|  | || .| ||.|| |.| .. 
kktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsal
subfamily_MTMR6_pd Subfamily MTMR6 1358-1572 3.7e-47 153.5 In-house 136-345 (397) alignment 
Range on Protein: 1358-1572
Range on HMM: 136-345/397.0
RLYALGEKSQAKSNMNVDFCAD--FIPVDYPDIRQSRPAFKKLIRACmpshNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLE
.| || .|.. |   | |. ..  |  |.  .|   | . .||. ..    ...  . ..| . .|.|.||. | .... |  .   .  .. ||..   
klnalankaagkGyenednysnikfqfvgienihvmreslqkllevv....elksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcs

DGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSNLKpshANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRF
|| | |||  |.|.| ||||||...|| ||.|||||.|||.| .|. |     . .  ..| |.|||. | ||..|||.|||||. .|  |  |  ||.|
dGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll...dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqf

RTFLFDCELERSDSGIA
 ||| .|| .| |  ..
Gtflgncekdrrdlklk
subfamily_MTMR1_pd Subfamily MTMR1 1376-1571 4e-56 183.0 In-house 146-335 (389) alignment 
Range on Protein: 1376-1571
Range on HMM: 146-335/389.0
FCADFIPVDYPDIRQSRPAFKKLIRACMPShntneADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPY
  |..| .| ..|.  | ..|||  ...|.      | ... . .|.. ||..|..... . ..|. .. ...||..  .|| | |||| |.|.| ||.|
knaelifldihnihvvReslkklkelvlpn.....vddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsy

YRSLDGFRVLVEKEWLAFGHRFAHRSNLkPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGI
||...||.||.|||||.|||.|..|      . ...   .| ||||.| |.||.||||.|||||. .| .|. |. ||.| ||||..| || .. .
yRtieGfevliekeWlsfGHkfkeRlgh.gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekv
subfamily_MTMR3_pd Subfamily MTMR3 1378-1571 1.2e-52 172.1 In-house 205-392 (442) alignment 
Range on Protein: 1378-1571
Range on HMM: 205-392/442.0
ADFIPVDYPDIRQSRPAFKKLIRACMpshntNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYR
.. . .. ..|   | .|..|   .      .  | . .   .|.  |||..| |.. .  ||. .| .. .|..   || | |.|. ..|.|.||||||
cevvflglanihavrksfnslralls.....qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyr

SLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANTNiAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGI
.|.||.||||.|||.|||.|| |.  ..   ..|   .| |||.||.||||||||| .||||. .|  |. |. || | |||...| ||... .
tleGfkvlvereWldfGhkfadrcghgenvddan.ercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekv
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1379-1568 3.5e-37 120.1 In-house 163-351 (405) alignment 
Range on Protein: 1379-1568
Range on HMM: 163-351/405.0
DFIPVDYPDIRQSRPAFKKLIRACMPS---HNTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIdLQESSVMLSLEDGSDVTAQLSSIAQLCLDPY
 .. .. |.|   | ...||. |   |   ..  |.    |  ..|.. |. .| |... .    .|| |.  |...   || | | |..|..|. ||||
klvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltqilldpy

YRSLDGFRVLVEKEWLAFGHRFAHRSNLKPSHANtniAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSD
||.. ||.||.|||||.|||.|. |    |   .     .| | ||||.. ||  |||. |||    | |..    ||.. ||| .|| .| .
yrtivgfqvliekewlsfghkfslrlghlpgnee...erspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvq
subfamily_MTMR10_pd Subfamily MTMR10 1384-1569 1.3e-43 141.3 In-house 122-305 (380) alignment 
Range on Protein: 1384-1569
Range on HMM: 122-305/380.0
DYPDIRQSRPAFKKLIRACMPSHNTN--EADgQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDG
. | |..   |..|| . |...  ..  ..| . .    |.. ||. .. .....  .|...  .. ||.|. ..|.|.   ..| |||.|||.||...|
elpsiqdvqkaylklreLcvidtseefvtld.dkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisG

FRVLVEKEWLAFGHRFAHRSNLKPSHAN-TNiafaPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDS
|  |..||| | || | .| .   .  .  .    |.|| |||.|.|| .||| .|||.. .|  |  .|.|. | ||||..| .|   
fqsliqkewvaaghpfldrlghikpsekses....pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlka
subfamily_pats1_pd Subfamily pats1 1386-1508 2.4e-19 61.2 In-house 344-464 (691) alignment 
Range on Protein: 1386-1508
Range on HMM: 344-464/691.0
PDIRQSRPAFKKLIRACMPSHNTNEAdgqsfAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQL---SSIAQLCLDPYYRSLDGF
|   . .  | .|... .   .....      | .|.| |.  .  |.. .  |  |.|  .| .. .  |. ... .|   ||.||. .||.||.||||
Ptrekveerffdllqsilsldgsdde.....wkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGf

RVLVEKEWLAFGHRFAHRSNLKPSHA
.||.||||| .|. |....  | |. 
kvliekewlsyGfPfskinyhkesdd
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1387-1571 1.6e-52 171.1 In-house 166-344 (404) alignment 
Range on Protein: 1387-1571
Range on HMM: 166-344/404.0
DIRQSRPAFKKLIRACmpsHNTNEAdGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLV
.| . | ..|||  |.   ....|   . . . .|.| ||..|..|.. |  .|.||. ..|||..   || | |.||||..||.|||||| . || ||.
nihelreslkklkkav...nsiiek.eknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivli

EKEWLAFGHRFAHRSNLkpSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGI
||||| ||| ||.|..   .. . .  ..| ||||.|.|.|| .|||  ||||. .|  . ... |||| |||.|.| ||... .
ekewlsfGhkfaqRigq..ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnl
subfamily_MTMR9_pd Subfamily MTMR9 1394-1572 3.2e-48 156.7 In-house 168-342 (393) alignment 
Range on Protein: 1394-1572
Range on HMM: 168-342/393.0
AFKKLIRACMpshnTNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAF
.. ||. ||.     .. . ..|.. .|.| ||.|.  |....  |....| ....|..  |.| | | |..|.||| |||..| ..||  |.|.||.  
slaklleacs....daglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqa

GHRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDSGIA
|| ||.| .    . ...   .|.|| ||| |.|. .|||..||||. .| .|  || |..| ||| |.| ||.. .. 
GHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklk
subfamily_pats1_pd Subfamily pats1 1510-1569 3.8e-15 47.3 In-house 548-607 (691) alignment 
Range on Protein: 1510-1569
Range on HMM: 548-607/691.0
TNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERSDS
 | .|.| |.||||.| |||..||. ||||...|  |  .| | || .||..  ...|. 
vnrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdser
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 1791-1839 4.9e-10 29.0 Pfam-A 1-51 (53) alignment 
Range on Protein: 1791-1839
Range on HMM: 1-51/53.0
HRFEKHPYTTPTNCNHCTKLL--WGPVGYRCMDCGNSYHEKCTEHSMKNCT
|..... .  || |.|| |.|   | .|..| .|. ..|.|| |.  |.| 
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecg
PH_3 PH domain 1887-1990 8.2e-07 17.7 Pfam-A 10-97 (104) alignment 
Range on Protein: 1887-1990
Range on HMM: 10-97/104.0
AENRTHEGHLYKRGALLkgWKQRWFVLDSIkHQLRYYDTSEDTApKGIIELAevqsvtaaqpAQIGAKGVDEKGFFdLKTSKRIYNFYAINANlAQEWIE
 |     | ..||  |.   ..|...| .   .| | | ....  || |.|            .. .. ...|.|| ..| ||.|...  ..| |..|..
gelilkqglvkKrkglf..arkRqlllteg.PrLiyvDpekmel.kGeIpls..........kelkvevknskkFf.ihtpkrtyyledpesn.aakWvk

KLQA
... 
aiee
PH PH domain 1892-1992 2.7e-15 46.8 Pfam-A 3-103 (104) alignment 
Range on Protein: 1892-1992
Range on HMM: 3-103/104.0
HEGHLYKRGALLKGWKQRWFVLDSikHQLRYYDTSE---DTAPKGIIELAEVQSVTAAQPAQiGaKGVDEKGFFDLKTSKR-IYNFYAINANLAQEWIEK
.|| |.|.. ||| ||.|.||| |  ..| |.. |.   . ||||.| | ...  .| .. . | .  ...  | ... ..  | ..| ..  ...|...
keGyllkksellktwkkryfvLts..nyLlyfksskkksykapkgsiplndctvkkasstkf.g.aqkesnnyfeitfknvesyllsaeseeerkrWvqa

LQACL
|. .|
lknll
PH_11 Pleckstrin homology domain 1893-1989 7.5e-09 25.7 Pfam-A 2-110 (112) alignment 
Range on Protein: 1893-1989
Range on HMM: 2-110/112.0
EGHLYKRGAL-LKGWKQRWFVLDSiKHQLRYYDT-------------SEDTAPKGIIELAeVQSVTAAQPAQIGAKGVDEKGFFDLKTSKRIYNFYAINA
.| |.| |.  |||||.|||.|     .|.||.              ||.  .|. .. . ... . |....  | .   .  |  .. .. . ... | 
kGylkkkgskllkgWkrrwfiLrk.dnvleYyksprdksdvalitkesekvilkkdlsis.nrlskianikdkkalelshsnefsiaaeekslflkgdnn

NLAQEWIEKLQ
.  .||.|.|.
eeteeWvealk
PH_8 Pleckstrin homology domain 1898-1989 1.5e-06 17.9 Pfam-A 6-86 (89) alignment 
Range on Protein: 1898-1989
Range on HMM: 6-86/89.0
KRGALLKGWKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVqsVTAAQPaqigakgvdEKGFFDLKTSKRIYNFYAINANLAQEWIEKLQ
||   |.|...|.||||  . .| || .....| .| | | .   . .|.          ||  . ...  ....  | |.. .|||.| |.
krrkklqgyakRfFvLdlksstlsYyrddnssalrgkiplsla..iisane.........ekreiiidsGaevWeLkasnekdfqeWveale