Gene aux in Drosophila melanogaster

Synonym: Auxillin/DNAJC6, CG1107, Dmel\CG1107, GAK, anon-WO0118547.393, auxilin, dAux, Dmel_CG1107, aux

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP034_AA protein Get Run
DmelP034_AA_398-584 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Pkinase_Tyr Protein tyrosine kinase 52-317 3.7e-28 88.3 Pfam-A 3-257 (259) alignment 
Range on Protein: 52-317
Range on HMM: 3-257/259.0
IKCVIAEGGYAFVYVAQDV----QTGTEYALKRL-IGADMQASTAIINEINIHKQLsGHENIVAFVGSSYtapsT--QlgaqYLLLTELCKGGSLVDCFR
..  ..|| .. |. ..      .. .. |.| |  .|. ........|..| |.|  |||||...|  .    .  .    .|..||...||.| .  |
lgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvct....keep....llivteyvegGdLlkfLr

TN-NAPFNPTCVLRIFYQMARAVASLHSQSppIAHRDIKIENFLIGNDKQIKLCDFGSASTEvlsptfewsaNQRSMLEDQLNTVTTPMYRSPEMLDTWS
.. . ... . .|.. .|.|.... |.|..  . |||.   | |. ..|..|..||| |..           ....  ... .. .   . .||.|.. .
kkekekltledllsfalqiAkGmeyLeskk..lvHrdLaarNvLleenkvvkisDfGLardi..........ekddyykkkekaklpvkWmapEslkekk

nnpIGPKVDIWALGCILYFLCY-RKHPYEDGGKLRII----NANYMLPPDPQYQCFSDIIRGCLKVNPFERLDITMVLE
   .  | |.|. | .|. ..   ..||..  . ...    . . .  |.   . . .... |.. .| .| ... ..|
...ftsksDvWsfGvllwEiftlgespypglsneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelve
Pkinase Protein kinase domain 53-317 1.8e-49 158.2 Pfam-A 4-256 (260) alignment 
Range on Protein: 53-317
Range on HMM: 4-256/260.0
KCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAII--NEINIHKQLsGHENIVAFVGSSYTapstqlGAQYLLLTELCKGGSLVDCFRtNNAPF
.  . .|... || |.. .||...|.|.|   . . ....   .|..|.|.|  |.||| .... ..        ...|..|...||.| |  . .. ..
leklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee......kdelylvleyveggdlfdllk.kkgkl

NPTCVLRIFYQMARAVASLHSQspPIAHRDIKIENFLIGNDKQIKLCDFGSASTEvlsptfewsanqRSMLEDQLNTVTTPMYRSPEMLDtwSNNPIGPK
. . . .|..|...... |||.   |.|||.| ||.|. .....|..|||.| .              .  |.  . | |. |..||.|   ... ...|
seeeikkialqilegleylHsn..giiHrDLKpeNiLldekgelkiaDFGlakkl............eksseklttlvgtreYmAPEvll..kakeytkk

VDIWALGCILYFLCYRKHPYEDG---GKLRIINANYMLPPDPQY-------QCFSDIIRGCLKVNPFERLDITMVLE
||.|.||.||| |. .| |...     .|..|...   . . ..       . . |.|. .|. .| .|| .. .|.
vDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeeilk
subfamily_Auxilin_pd Subfamily Auxilin 406-576 2.5e-67 218.7 In-house 3-166 (166) alignment 
Range on Protein: 406-576
Range on HMM: 3-166/166.0
SLARNDLDISHITSRILVMPCPSDGFESTYKtNNIEDVRLSLESRFvPQKLSIYNFGQRTEPRLPPPVRTVEAGsvygCPQAHAPNLQGLFTVSADMYNF
| |.||||||.|||||.||..|..|.||||| |||.|||..||||. |.|...||..|||... ....|.||||    .|...||||..|..|....|..
syakndlDisyitsriivmsfPaegvestyk.nniddvrsfLesrh.pekylvynlsqrtyrtaklssrvveag....wparraPnLeslvevcrnlysw

LNADPKSVVIVQTGDsGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRP
|..|||.||.|.. | | ...|....|||....||.|||.||..|.|||..|.|.|||.|||.|..|.|..
lkkdpknvvvvhckD.Graasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryleyladllae
PTEN_1 407-575 3.4e-13 44.8 In-house 15-193 (196) alignment 
Range on Protein: 407-575
Range on HMM: 15-193/196.0
LARNDLDISHITSRILVMP-CPSDG-----FESTYKtNNIEDVRLSLESRFVPQKLSIYNFGQRTEP-RLPPPVRTVEAGSVY----GCPQAHAPNLQGL
|  ..||...|||||..|  .||..     .|..|. ....||.  |...  .   ...|.  . |  . . . .. ... |     . .  .||.|. |
lptelldltyitsriiamgkapsrpllqeideglyr.gslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslsel

FTVSADMYNFLNADP-KSVVIV--QTGdSGgcTAATVICALLMYADLlREPEDAVQVFAVKRHTINLR-PSEFRYLYYFGDILR
| . ... . | .|| . ||.|  . |  |    .||..|.|||.     ...|.. .. ||  .... ||  |.|.|| ..|.
fdicksfiewllsdpngnvVlVHCkaG.lg..RsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_PTEN_pd Subfamily PTEN 409-575 2.8e-22 74.6 In-house 17-180 (184) alignment 
Range on Protein: 409-575
Range on HMM: 17-180/184.0
RNDLDISHITSRILVMPCPSDGFESTYKtNNIEDVRLSLESRFvPQKLSIYNFGQRTepRLPpPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNA
  |||.|.||..|..|  |... |..|. |..|||   ||...  ..  |||. .    .     .  .  .||..   ..|.|. | ..  |. ..|..
gldLDlsyiteniiamgyPaeklealyR.nsledvvkflekkh.kdhykiynlrser..kyd.skkfdgrvavypfdDhnppplelleeivediekwlee

DPKSVVIVQTGDsGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTIN---LRPSEFRYLYYFGDILR
|.| ||.|     |   . ..|.|.|... ||...|.|...|| .| . .     ||  ||..|. ..|.
dkknvvvvHCka.GkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklle
subfamily_Tensin_pd Subfamily Tensin 409-575 1.1e-20 66.9 In-house 8-172 (189) alignment 
Range on Protein: 409-575
Range on HMM: 8-172/189.0
RNDLDISHITSRILVMPCPSDGFESTYKtNNIEDVRLSLESRFVpQKLSIYNFGQRTEPrlpppVRT-VEAGSVYGCPQAHAPNLQGLFTVSADMYNFLN
. |||...||.||... .|..| |..|. .|..||   |.|.   .|. ..|  ..        .    .    .| |. .|| |. | ..  .. ..|.
kvdldltyiteriialsfpaegleekyr.enlkdvakllkskhn.dkylvfnlsekryd.....isklnkkvldfGWPdllaPsleklcsicksldsWlk

ADPKSVVIVQTGDSGGcTAATVICALLMYADLLREPEDAVQVFAVKRHT-----INLRPSEFRYLYYFGDILR
|||. ||.| .  . |   . |. | . |...    . |.. ||.|| .      ...||. ||. || ..| 
adpqnvvvvhckGgkg.rigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLs
0036282 (Phosphotyrosine protein) phosphatases II 410-574 4.9e-16 54.4 In-house 8-169 (174) alignment 
Range on Protein: 410-574
Range on HMM: 8-169/174.0
NDLDISHITSRILVMPCPSDgFESTYKTNNIEDVRLSLESRFvPQKLSIYNFGQRtepRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNAD
..||.|.||.|.... .| . |   .| ..|..|   ||..  ...  ..|.  .   .   ..|..     ...|  ..|.|. |...   ....|. |
spldlsyitprliagqgpla.fwemlkelgittvvmlleeke.lglykcinywpe...lredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

PKSVVIVQTGDSGGCTaATVICALLMYADLLREPEDAVQVFAVKR---HTINLRPSEFRYLYYFGDIL
|. .|.|      | | .|...|.||.  ||  ..||..... .|   . .  .|| .|.||||...|
pggpvlVHCsaGvgRt.GtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_VSP_pd Subfamily VSP 411-572 8.7e-14 45.9 In-house 33-196 (212) alignment 
Range on Protein: 411-572
Range on HMM: 33-196/212.0
DLDISHITSRILVMPCPSDGFESTYKtNNIEDVRLSLESRFvPQKLSIYNFGQRTEprLPPPVRTVEAGSVyGCPQAHAPNLQGLFTVSADMYNFLNADP
|||....| ||. |  || | .| |. | |..|   |. .. ...  ..|     .    . .   .   .    .   |.|. |.... .. ..|..|.
dldltyvteriiamsfpssGkqslyr.npisevarfldtkh.rdhykvvnlcsera..ydekyfnnrvkri.liddhnvpkleellvftkevkewlekdl

KSVVIVQTGDsGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINL--------RPSEFRYLYYFGD
| |...     |   . |..||||........ ..... |...|   .          ||. ||. |. .
knvlaihckG.GkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq
0046846 (Phosphotyrosine protein) phosphatases II 411-572 5e-06 21.9 In-house 9-170 (176) alignment 
Range on Protein: 411-572
Range on HMM: 9-170/176.0
DLDISHITSRILVMPCP----------SDGFESTYKTNNIEDVrLSLESRFVPQKLSIYNFG-------QrteprlpppvrtveAGSVYGCPQAHAPNLQ
|||.. |. .......|             |   .| ..|. | ..| ...  ..|...|.                          ... |  ..|.|.
dldldyinanlilgsrpiatqgplprtladflemlkelgitav.vnlteevelgrlkcpnywpeleklgi..............qylhlpwpDhgvpdle

GLFTVSADMYNFLNADpkSVVIVQTGDSGGCTaATVICALLMYADLLREPEDAVQVFAVKRH-TINLRPSEFRYLYYFGD
 |... . ....|...   .|.|      | | .|...|.|.. .    .|.|.. .  .|.  .   |.  |.||.|  
lllellefirealkeg..gpvlVHCsaGigRt.gtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 583-713 6.1e-25 78.9 Pfam-A 3-132 (134) alignment 
Range on Protein: 583-713
Range on HMM: 3-132/134.0
YKNTTLVSLSCQPVPRMtKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVRPQGlkICQFQFNTGFIPE
 |. .|.|. ....|.. | |.||.....|| . . . ..|..|.... ..|    . .| .|. .||| | ..| .. ... .   |....||| ||..
pkrlelksiilegiPnf.ktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkek..ifrvwFNTsFiek

PETLITFTNQDLDDLPDP--EQVTPRFCVSLSL
 ....|.. ..||.. .   ..... | |.| .
nqnvltlpkneLDkalkdkdkkfsknfkvelvf
DnaJ DnaJ domain 1109-1156 5e-11 31.5 Pfam-A 12-57 (64) alignment 
Range on Protein: 1109-1156
Range on HMM: 12-57/64.0
VTPTEVKKAYRRACLAVHPDKHNGTEneEIAKLIFMELNNAWTDFEND
 .  |.|||||. .| .||||... |  | |.  | |.|.|.   ...
asdeeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevLsdp