Gene Ptp61F in Drosophila melanogaster

Synonym: BEST:LP01280, CG9178, CG9181, DPTP61F, Dmel\CG9181, PTP61F, Ptp-61F, R-PTP 61F, anon-WO0118547.297, anon-WO0140519.98, dPTP61F, dptp61F, ptp61F, Dmel_CG9181, Ptp61F

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP040_AA protein Get Run
DmelP040_AA_28-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN23_pd Subfamily PTPN23 21-301 2.7e-65 215.0 In-house 8-284 (288) alignment 
Range on Protein: 21-301
Range on HMM: 8-284/288.0
AEYKDKGPQWHRFYKEICETCDREakEKQFSTSESERHTNRglNRYRDVNPYDHSRIVLKRGSVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMV
 .. |   . .. .||. .. |.|   ...|.. .......  ||.||. ||||.|..|. .  |||||  |. |     ..| ||.||  |.. |||||
rkmldgktaldkkfkeleqkqdke..arkrsiaiaklysek..nrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKAlklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQ
.||||. . || .  |... |.. |||.. |. .     . .|.| | . .. ...|.| .||. |.... ..|.  ..|.||..|.|.||. .|.||..
yeqkssviVmllskeelgkpkvdrYwPedkgetvk....fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VRD--SGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID-KYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLH
|..  .    .   | |||||||.||.|.|.|| . .  .. . |  .. .|.  ||  |   .|. .|| |||.|..| ...  
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 22-287 1.7e-30 100.8 In-house 14-271 (301) alignment 
Range on Protein: 22-287
Range on HMM: 14-271/301.0
EYKDKGpQWHRFYKEICETCDREAKEKQFsTSESERHTNRGLNRYRDVnPYDHSR--IVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMV
..||.  .  .||.   |  .  . .|.    ||  . ..  .||  | | . |    |.. |    | || .. .   ...| ||||| .|   || |.
dfkddd.ktakfynttienvnvttidkdh.itesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwaml

WEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQ-QSREVMQFHYTTWPDFGIPSSPNAFLKFLQ
   .   . || . .||.. ||. | | ...  . |..   |....   |   .. ..| ....|   . ..| |. . |..|.| |.| |     ....
vqydvekivmlgqkvekleekceeylpvkis..ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme

QVRDSGclsrdvGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLD
 |..|        | ||||||||||| .|   ..    ..   . .... | .||  |   .||  || 
lvkkse......kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 23-296 4.4e-47 155.9 In-house 29-290 (319) alignment 
Range on Protein: 23-296
Range on HMM: 29-290/319.0
YKDKGPQWHRFYKEICETCDREAkEKQFstseSERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLM
..|.  . .  .. .|.     | ...|    ..   |.  ||. .. ..|.... |.|       |||||  |.  . . .|| .|||| .|.  || |
fdddltklevefrracklgvnla.dqtf....anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrm

VWEQKSRAVLMLNklmekkQIKCHLYWPNEMGAdkalKLPHVKLTVELVRlETYQnFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFL
.||... ....|       . ||  |||...      |  . |. |..|  || . .| | ..|..  . .. |.. |||.  ||| | | .|  .....
iweyncstivllt......kdkcsqywplkivi....keerfkvkvdsve.etae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

QQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
..||      ..  . |||||||.||.|..  .|. |  ...    .| ... .||  |  |.|   |  | | |..| 
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0039614 (Phosphotyrosine protein) phosphatases II 26-300 1.2e-77 256.6 In-house 27-292 (297) alignment 
Range on Protein: 26-300
Range on HMM: 27-292/297.0
KGPQWHRFYKEICETCDREAkekqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLERA-ERQYILTQGPLVDTVGHFWLMV
|  . .....|  | ..        ..|....  |. .|||.|. ||||||..||       . |||||..|.  .   |..|.||||| .||..|| ||
kansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WEQKSRAVLMLNKLMEKKQiKCHLYWPNEMGadkalklPHVKLTVELVRLETYQNFVRRWFKLTDleTQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQ
|||......||.||.|... ||. |||.|.|        . ..||.|.. |.......|....|.  ...||.|..|.|| |||.|.|.|.. .|.||..
weqgvtvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflel

VRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
||.    ... || .||||||.||.|||.. . .| ...|.|. .| ....|||..|.| .|| .|. | |.|..| .|. 
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN1_pd Subfamily PTPN1 28-308 3.3e-145 477.3 In-house 2-282 (290) alignment 
Range on Protein: 28-308
Range on HMM: 2-282/290.0
PQWHRFYKEICETCDREAKekQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAV
 ...|.||||......||.  .|.|.|.....||.|||||||.|||||||.|.|...|||||.||.||.|.|.||||||||..||.|||.|||||||.||
ldkkrlykeiyldirkeas..dfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

LMLNKLMEKKQIKCHLYWPNEMGaDKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLS
.||||..||.||||. |||..   .|.|.| ..||.|.|.. |.......|...|..|.||..||...||||||||||.|.||.||||||..||.||.||
vmlnkvvekeqikcaqywPqgee.ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls

RDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE---CNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDA
.||||||.||||||||||||||||.|||||.|...   ....|||.|||.||.|||||||||.|||.||.||.|......... 
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqk
0045450 (Phosphotyrosine protein) phosphatases II 28-296 4.6e-79 261.6 In-house 24-303 (307) alignment 
Range on Protein: 28-296
Range on HMM: 24-303/307.0
PQWHRFYKEICETCDREAKEkQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLV--------QLERAERQYILTQGPLVDTVGH
  .....||. . .. . .   ...|....  |. .|||.|. ||||.|..|.      .. |||||. |        .  .  |..|.||||| .|| .
dfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmGADKALKLphvkLTVELVRLETYQNFVRRWFKLTDL-ETQQSREVMQFHYTTWPDFGIPSSPNAF
|| |.|||......||..|.|....||. |||.| |  .  .     .||.|.. |.......|....||| .|..||.|..||||.|||.|.|.|.. .
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LKFLQQVRD------SGclsrdvGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE---CNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
|.|...||.      .|      || .||||||.||.|||.. . .|....| |.   ... .....||. |.| .|. .|. | |.|..| 
ldfieevrkaleelpkg......gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_eak_pd Subfamily eak 28-226 1e-17 58.5 In-house 20-213 (332) alignment 
Range on Protein: 28-226
Range on HMM: 20-213/332.0
PQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNrYRDVNPYDHSRIVLK---RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKS
  | |  . |    | . ...  | ||..|  .   |   .. |||.  . |    .    |||| |...    |.||||  .  | |  || || ||||
hiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqks

RAVLMLNKLMEKKQIKCHLYWPNEmgADKALKLPHVKLTVELVrlETYQNFVRRWFKLTDleTQQSREVMQFHYTTWPDFGIPSSpNAFLKFLQQVRDSG
 |...| . .|.|  |   |.|..  . . ||  .....         ...  | ..|.     .. .|. ...  | .. .|   . || . . ... |
paivqlledvelkleksdkyfpdk..treelkfGildverkef..vkrniletrllelsk..GnethrvlhykvfGwtettlpky.edflalrkvmkevG

CL
 |
vl
0050432 (Phosphotyrosine protein) phosphatases II 29-299 2e-88 292.0 In-house 40-301 (308) alignment 
Range on Protein: 29-299
Range on HMM: 40-301/308.0
QWHRFYKEICETCDREAkekQFSTSESERHTNRGLNRYRDVNPYDHSRIVLkRGSVDYINANLVQLE--RAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.......|  | ..       ...| ...  |. .|||.|. ||||||..|  .. |||||..|..   . .|..|.||||| .||..|| |||||..| 
dlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

VLMLNKLMEKKQIKCHLYWPNEMG-ADKALKlphvKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGc
. ||.||.|....||. |||.|.|   .  .    |.||.|.. |.......|...||.|....||.|..||||.|||.|.|.||...|.||..||.|  
IvmLtklvengrekcaqYwplelgggsleyg....kftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

lsRDvGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  .. || |||||||.||.|||...|..| ...| |...| .... ||..|.| .|| .|. | |.|..| .|.
..pg.gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0047943 (Phosphotyrosine protein) phosphatases II 30-297 2.7e-84 278.2 In-house 14-272 (273) alignment 
Range on Protein: 30-297
Range on HMM: 14-272/273.0
WHRFYKEICETCDreakekQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLM
... .........      ....| ...  |. .|||.|. ||||||..|. |. |||||..|.. . .|..|.||||| .||..|| |||||..| . |
lleefelllslkp......lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LNKLMEKKQIKCHLYWPNEMGAdkaLKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRD
|..|.|....||. |||.|.|    |.| . |.||.|.. ||..... | ..||.|.|..||.|..||||.|||.|.|.|.. .|.|...||.    ...
LtelvelgrekcaqYwplegge...lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

VGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
 || |||||||.||.|||...|..| .. |.|. .| .... |||.|.| .|| .|. | |.|..| .
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN12_pd Subfamily PTPN12 30-299 2.6e-64 211.9 In-house 10-279 (290) alignment 
Range on Protein: 30-299
Range on HMM: 10-279/290.0
WHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSR
... .... .. ..  .||..||...|...|.  |||.|. |||.||..|..       ||||||...    . .|| .|||| .|.  || |.||.. .
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknve

AVLMLNKLMEKKQIKCHLYWPNEMGADKAlkLPHVKLTVELVRLeTYQNFVRRWFKLTDLetQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGC
 |.|. ...| ...||. |||.|.. .      ....|.|  .  . ..|. | .|..    ..||.| ||||| ||| |.|||..  |.....||.   
ivvmaCrevelgkkkCerYWpeegeeele..fgefevtleeeka.vdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

lsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  ..  | |||||||.|| || . .|    |. .     | .| ... |||  |  |.|| .|  . |.|..| ..|
..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
0040438 (Phosphotyrosine protein) phosphatases II 31-306 1.4e-82 272.8 In-house 18-285 (317) alignment 
Range on Protein: 31-306
Range on HMM: 18-285/317.0
HRFYKEICETCDReakeKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.....| .. ..     |  ..|..|.  |...|||.|. ||||||..|.  .     |||||..|.  .  |..|.||||| .||..|| |||||... 
talleefedllsl....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VLMLNKLMEKKQIKCHLYWPNemgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCl
..||..|.|....||. |||.    .. |.  .  .||.|.  |...... |.....||....||.|..||||.|||.|.|.||. .|.||..||..   
ivmLteleelgrekcaqYwpl....getltygd..ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.

sRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFL
 .. || .||||||.||.|||......| ...|.|...| ....|||..|.| .|| .|. | |.|..| .|. .  . .
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa
0043336 (Phosphotyrosine protein) phosphatases II 31-295 1.8e-74 246.0 In-house 20-275 (278) alignment 
Range on Protein: 31-295
Range on HMM: 20-275/278.0
HRFYKEICETCDREAkekqFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.....|  | ..       ...| ...  |. .|||.|. ||||||..|.  .     |||||..| . .  |..|.||||| .||..|| ||||.... 
tllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VLMLNKLMEKKQIKCHLYWPnemgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCl
..||..|.|....||. |||     .. |.  .  .||.|.. |.......| ...|.| . .||.|...||. |||.|.|.|.. .|.||..||.    
ivmLtelvelgrvkcaqYwp.....ggsltygd..ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.

sRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
  . || .||||||.||.|||.... .| ...|.|. .. ....|||..|.| .|| .|. | |.|..|
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRN_pd Subfamily PTPRN 31-300 1.3e-51 170.1 In-house 29-295 (297) alignment 
Range on Protein: 31-300
Range on HMM: 29-295/297.0
HRFYKEICETCDREAKEKQFSTSESERhtNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLV-QLERAERQYILTQGPLVDTVGHFWLMVWEQKSR
.|. ||    |. ||...  .....|.  |   ||...| ||||||. ||.     . |||||  . . .  .  || ||||| .|| .|| ||||| . 
drlekewealcayeaepstkevakaek..nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

AVLMLNKLMEKKQIKCHLYWPNEmGAdKALKLPHVKLTVELVRLETYqnfVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgC
 ...| .| |.   .|. |||.| |. .  ..  |.|  | .  . |   . | | | .|.|...| | |||. .||. |.|.|....|.| ..|    .
vivnltrleeegvkqckrywpde.Gs.evyhiyevhlvsehiwcddy...lvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk..s

LSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDK-YGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
      | |||||.| ||.|...|.|  |  . |   | ...  |  ||  | ||..| ||..| ..|..| ....
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnai
subfamily_CG7180_pd Subfamily CG7180 31-295 1.3e-49 163.5 In-house 16-288 (296) alignment 
Range on Protein: 31-295
Range on HMM: 16-288/296.0
HRFYKEICETCDReAKEKqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.  || ....  |  .          |..||. ||. .| |||. |.||..     . |||||  |.    ...|| |..|  .||. || .|..... |
rveyklelkltpr.leig..dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

VLMLNKLMEKKQiKCHLYWPNEMgadkalKLPHVKLTVELVRLETYQNFVRRWFKLTDL----------ETQQSREVMQFHYTTWPD-FGIPSSPNAFLK
| .| | .. .. ... ||||..      |  . .. ||.|. ..| |.. | ||||            .. . | |..|..|.|.    .|.| ||...
vvvLtktfdfak.mypsywpnks......keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalie

FLQQVRDSGCLS---RDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
....||          . || ||..| | .||| .. .| .| |..| .| .| . .  ||  | .|... ..  . |. . |
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 32-298 1.8e-41 137.0 In-house 20-280 (439) alignment 
Range on Protein: 32-298
Range on HMM: 20-280/439.0
RFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAV
 ..||| |. .    . .  .|   .. ..  |||.|| ..||.|..|.         ||||| ..    .. || ||||  .|. .|| .|.|.|.  .
eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

LMLNKLMEKKQikchlYWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDL--ETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVrDSGC
.|| .|.|  .     ||| .  .       .  ..|   |     |.| | ||. .    |.. | |.||||..|||  .|.     |.||. . .|  
vmltnlvesyk.....ywpsdaevc......ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrai.nsan

LSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
 ....|| |||||||.||.||   .| .|  .    . ..  ..  ||  |  ..|.  |  | |.|..| |.
dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
0051299 (Phosphotyrosine protein) phosphatases II 33-297 6.3e-83 273.8 In-house 28-286 (288) alignment 
Range on Protein: 33-297
Range on HMM: 28-286/288.0
FYKEICETCDReakekqFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVL
 ..|... .        ...| . .  |.  |||.|. ||||||..|.     .. |||||..... . .|..|.||||| .||..|| |||||..| . 
efeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

MLNKLMEKKQIKCHLYWPNemgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDL----ETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG
||.||.|....||. |||.    .. |.. .  .||.|.. |...... |....|.|     ...||.|..||||.|||.|.|.||...|.||..||.. 
mltklvelgrekcaqYwpl....ggsltygd..itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

ClsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
    . || |||||||.||.|||...|..| ...| |...| .... ||..|.|..|| .|. | |.|..| .
a..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 35-299 3.3e-68 224.9 In-house 29-299 (306) alignment 
Range on Protein: 35-299
Range on HMM: 29-299/306.0
KEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSV---DYINANLVQ--LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLM
.|  |. ..|...|..| .|... .|.  |||. . |.||.|..||. ||   |||||| ..  ..  ...|| ||| | .||  || |||...|| ..|
eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LNKLMEKKQIKCHLYWPNEMGADKalklpHVKLTVELVRLETYQNFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSR
. | .|. . ||  |||.|   ..     . |..|. |. .. .... | ....   . ...|||.|.|...||| |.|..|.|.|.||..|.     ..
ttkevErgkekCarYWPdeeekee.....yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

--DVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYG---ECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  . || |||||||||| ||| ..|. | || | |   .... |.   .|..| ||.||..|  | |.|| . |..
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPRG_pd Subfamily PTPRG 39-298 5.3e-62 204.8 In-house 26-288 (563) alignment 
Range on Protein: 39-298
Range on HMM: 26-288/563.0
ETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKL
|   .| ..|.. .. |... |.  ||| .. .||.||. |.      .. |||||| ..  . ....| ||||| ||.  || |.|||..  . |. .|
ealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnl

MEKKQIKCHLYWPNemGADKALKLPHVKLT-VELVRLETYQNFVRRWFKLTDLET-QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVrdSGCLSRDVG
 |... ||. |||.     . ..  .|.|.  | . | | ...| . .|| . .  .. ..|.|.|||.||| | |...   |.| ..   |    ...|
vergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaG

PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
| |||||||.||.||.. .|  |  | .    || ..|  .|. |  |.|| .|  | ..|..| |.
PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
DSPc_SM00195 41-297 3e-79 261.4 In-house 9-262 (263) alignment 
Range on Protein: 41-297
Range on HMM: 9-262/263.0
CDREAKEKqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEK
 ......|  .|.|.|.. |.  |||... ||||.|. ||.       |||||| ..... ...||.||||| .|| .|| ||||.|.. ..||.. .|.
leestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

KQIKCHLYWPNEMGADKALKlphvKLTVELVRLETYQ-NFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrdVGPAVV
...||. |||.|.|  .  .    |..|.||. |... ....| ..||  .....|.| |..|..||| |.|.|.. .|..|..|. |   |   || ||
gkekcdrywpeesggketfg....kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
|||||.||.|||...|..|  .... . .......|||. |.|..|| .|. | |.||.| |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 41-297 3e-79 261.4 In-house 9-262 (263) alignment 
Range on Protein: 41-297
Range on HMM: 9-262/263.0
CDREAKEKqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEK
 ......|  .|.|.|.. |.  |||... ||||.|. ||.       |||||| ..... ...||.||||| .|| .|| ||||.|.. ..||.. .|.
leestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

KQIKCHLYWPNEMGADKALKlphvKLTVELVRLETYQ-NFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrdVGPAVV
...||. |||.|.|  .  .    |..|.||. |... ....| ..||  .....|.| |..|..||| |.|.|.. .|..|..|. |   |   || ||
gkekcdrywpeesggketfg....kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
|||||.||.|||...|..|  .... . .......|||. |.|..|| .|. | |.||.| |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 42-225 2.3e-31 103.8 In-house 17-197 (297) alignment 
Range on Protein: 42-225
Range on HMM: 17-197/297.0
DREAKEKQFSTSesERHTNRGLNRYRDVNPYDHSRIVLKRGS--VDYINANLVQL--ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKK
 .||. ..||..   | .    |||||.  .| .|. |.|.    |||||. | .  | |. .|||.|||| .||  || .|.||  |.. |. || |  
ldeargesfssa..krnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedG

QIKCHLYWPNEMGAdkALKLPHVklTVELVRLETYQnFVRRW-FKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdSGC
. ||  |||.  .    || ..|   || .   . . | |    .|. .  ..|| |    . .||| |.||  .   .|  ||  | |
rdkcapywpsvvqe..rlkagdv..vveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvc.scc
subfamily_egg_pd Subfamily egg 43-255 2e-17 57.9 In-house 25-226 (307) alignment 
Range on Protein: 43-255
Range on HMM: 25-226/307.0
REAKEKQFSTSESERHTNRglNRYRDVNPYDHSRIVL--KRG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKkq
  ..|. . |. |. . ..   | . |.  | ||. |  .||  . |.| || |. .    ..||.| || .||  || ||.... . ..||.   |   
esvdeislttaasdnnlek..arskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..

IKCHLYWPNEMgADKALKLPhVKLTVELVRLETYQNfvrRWFKLTDLETQQS-REVMQFHYTTWpDFGIPSSPNAFLKFLQQVRDsgcLSRdvgPAVVHC
 .|. |||.   .| .  .|   | .| ....   .     |..| |    . .| .   .  . |.   |     |. |...|.   ||.   |.||..
erceyywpkae.sdslvtvp.Gslrienlkvdskad...plfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrn...lsk...pvvvqd

SAGIGRSGTFCLVDCCLV
  |. ...|.  ..  |.
ilGvskaatlvaieiall
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 44-298 4.6e-64 211.5 In-house 40-291 (298) alignment 
Range on Protein: 44-298
Range on HMM: 40-291/298.0
EAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI
. . ...... .....|.  ||| |. ..|.||.||..       |||||  ..  . .  .|.||.||. ||  || ||.|... .. ||..| |....
sseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldkt

KCHLYWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgcLSRDVG--PAVVHC
|.| |||.|  .       . ..||.| . |.. ... | .|... .....||| |.|.|.||| |.|.  .. |..|..||      .. |  | .|.|
kyhkywPdegket......ygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra...sqqqagnkpvivqC

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
|||.||||||. .|  |  . |     | .|.  ||  |.|..|| .|  | |.|..| ..
saGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Ptp69D_pd Subfamily Ptp69D 44-299 8.3e-60 197.5 In-house 32-288 (307) alignment 
Range on Protein: 44-299
Range on HMM: 32-288/307.0
EAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI
||.| . ||. ||.. |   ||| |. ..|. |..||.     . |||||. ..  . ....|  |.|.  |.| || |..||..  . || .| ||.. 
eareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrk

KCHLYWPNEmgadKALKLPhvKLTVELVRLETYQNFVRRWFKLTDLE-----TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrdVGPAV
||. |||.|    .  .    .. |.||. |. .....| ....  .      ..||.|.|.|||.|.|. .| .... ||...|||.   |.   .| |
kcakYWpie....devqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPiv

VHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|||||| ||||.|  .|  |  . .  . .. .. ..||| |  |.|  .|  | |.|... ...
vhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPN14_pd Subfamily PTPN14 44-299 9.3e-57 187.3 In-house 35-298 (300) alignment 
Range on Protein: 44-299
Range on HMM: 35-298/300.0
EAKEKQFSTSESErhTNRGLNRYRDVNPYDHSRIVL---KRGSVDYINANLVQLE--RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQ
. .. ..||.. .   |   ||..|| ||...|. |   |  | .||||  ..     .||.|| .||||  ||  || |||||. . ..|| .  |. .
kredallstaklp..enaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

IKCHLYWPNEMGADKALKLPHVKLTVELVrlETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSR-------DVG
 |.. |.|..    | ..  . |.| ...  |. . .. . .||  | ... |.|. . || ||| |.|. .. ||..|..|.     .           
eksfkyfPkleskkktvefgkfkvttkfs..edsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
| .||||||.||.|   |.|  .  ...  | .. |||  ||  || |.||  |  | |...|. .|.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 44-295 8.4e-54 177.3 In-house 22-275 (287) alignment 
Range on Protein: 44-295
Range on HMM: 22-275/287.0
EAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR---GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIK
...   .   ..|   .   ||| || |.|..|..|       .|||||| |   . . ..| .|||.  ||. || .|.|..| .|... . .|. . |
dsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

CHLYWPNEmgaDKALKLPHVKLTVeLVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSR---DVGPAVVHC
|. |||.    .. ...    ... | .     ..  | ..| ||||...| | |... .||| ... .  ....|  .|..   |.|   .||| |||.
cykywPer...evPmrvGGysvvl.ldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
..||||||..  .  ..    . |. .|..|.  || || .|.|.. || ..|.|.. 
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_PTPRD_pd Subfamily PTPRD 46-300 1.2e-80 266.8 In-house 34-284 (564) alignment 
Range on Protein: 46-300
Range on HMM: 34-284/564.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
...||...... ..|.  ||| .. .|||||.||..     . |||||. ..  |....|| ||||| .|.  || |||||.|. . ||.|| ||.. ||
egqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkc

HLYWPNEmGadkalKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGI
| |||.. |     .  . .|||.|.  |...... | |||.. ....|||| |||.| ||| |.| |....|.....||..   ..| || |||||||.
hkYWPek.g.....tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivVhCSaGV

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
||.|||. .|..|  | . .  .. ... .||. |  ..|| .|  | ..|| | ... 
GRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
subfamily_PTPN3_pd Subfamily PTPN3 46-296 1.6e-69 228.9 In-house 27-274 (280) alignment 
Range on Protein: 46-296
Range on HMM: 27-274/280.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAE----RQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
|... ..|.. .  |   |||||. |||. |. || ...|||||| |..|        .|| ||||| .|. .|| |||||||. ..||  |.|. ..||
kkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

HLYWPNemgADKALKLPhvKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGI
| |||.    .. |..   ...|.. . .. ...| | . |.| ||...|...|. |. ||| |.|.... ||.|...||.    | .  | ||||||||
hqyWPe...tedeleyg..efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCsaGi

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
||.| . |.. .| ||..  . .. ... ..|  |. |.|||.|  |  .||.. 
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 46-298 1.7e-67 222.7 In-house 32-281 (318) alignment 
Range on Protein: 46-298
Range on HMM: 32-281/318.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
.|..... .|   .|.  ||| .. .|||.|. |.      . |||||| ..  |....|| .|.|| .|.  || |||||.|. ..|| ...|. ..|.
seetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv

HLYWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLSRDVGPAVVHCSAGI
| |||..          . ||.|||    .....| | ||.|  |...||.| |.|||.||| |.|.|.  .|....||.    .. ..|| |||||||.
hryWPskgsrs......ygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq.qksgagpivvhCsaGv

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
|| |.|. ||  |  | . .  .| ..  .||. |  ..|| || .| |....| ..
GrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 46-295 1.7e-64 212.6 In-house 33-277 (288) alignment 
Range on Protein: 46-295
Range on HMM: 33-277/288.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
 ||. |.. ...  |   ||||.. |||. |. ||      . |||||. .. |. ...|| ||||| |||..|| .|.|.|.  ..||..|.|. . ||
lektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkC

HLYWPNEmgaDKALKlpHVKLTVELVRLETYQNFVRRWFKLTdlETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGI
. |||..   ||  .  . ..||.||  .. ..|| | . |    ... .|. |..|..||| |.| | . .|..|.||  .   . |.|| .||||||.
eeYWPda...dkpkn..yGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan..qadtgpiivhCsaGv

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
||.|||  .|. .  ....   .|  ....||  |. |.||  |  | |.....
GrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 46-299 4.6e-50 165.1 In-house 32-285 (290) alignment 
Range on Protein: 46-299
Range on HMM: 32-285/290.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLK--RGSVD----YINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI
 |.....       |. |||.... .||  ||.|.   |  |    ||||  ..  . ..|||.||||. .|. .|| ..|..|. ...|| . .|... 
gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkv

KCHLYWPNEmGADKaLKLPHVKLtvelVRLETYQNFVRRWFKLTDLET-QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLsRDVGPAVVHCS
||. |||.. .... .   ..||    .  ||......| ..... .. .....|.|.. |.|.. |    |.. |  .... .     |  .. |||||
kCqqYWpds.dtka.ygefsikl....lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk.rgntsivvHCS

AGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
...|||..|| ..  .    . |  .| .|| ..|. ..|..||..|. . .| ... ...
dtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0036941 (Phosphotyrosine protein) phosphatases II 47-299 1.6e-85 282.3 In-house 26-279 (297) alignment 
Range on Protein: 47-299
Range on HMM: 26-279/297.0
EKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP
 ...|.| .... |. .|||.|. ||||.|..|. .. |||||..|.. . .|..|.||||| .||..|| |||||... ..||..|.|.  .||. |||
lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp

NEMGADKALklphVKLTVELVRLET--YQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRS
.|.|  .       ..||.|.. |.  ......|....||.....||.|..||||.|||.|.|.||. .|.|...||.   |... || .||||||.|||
leegeslty....gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GTFCLVDCCLVLID---KYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|||...|..| ...   |.|.... .....||..|.| .|| .|. | |.|..| .||
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_PTPRB_pd Subfamily PTPRB 47-299 6.9e-72 236.9 In-house 38-287 (293) alignment 
Range on Protein: 47-299
Range on HMM: 38-287/293.0
EKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCH
.|. ... .|...||  |||... ||||||. |    .. . |||||| ..  ...|..| ||||| .|| .|| ||||.||....|| .|.|| ..||.
gkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCe

LYWPNEmgadkALKLPHVKLTVELVRLETYQNFVRRWFKLTDleTQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIG
 |||..          . ...|.||  |.....| | .|..   ....|.|.|.|.|.|||.|.|......|.|...||..   . . .| |||||||.|
eYWPad.....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|.|||  .|  |  |..    ..  ...|||. |. |.|| .|  | .|.... ..|
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 48-298 1e-58 193.9 In-house 36-284 (319) alignment 
Range on Protein: 48-298
Range on HMM: 36-284/319.0
KQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHL
........... |.  |||... .||..|.||.      . |||||. ..  . ....| ||.|| .|.  || ||||..|  |.||.|| || ..|.. 
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkk

YWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQ-SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGClSRDVGPAVVHCSAGIG
|||.|   .        .|.|.|   |  .... | .||  . ..  .|||..|.|| ||| ..| .  . |..|...| |     . || |||||||.|
ywpeenfee......yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre.ktqsgPivvhCsaGvG

RSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
| |||. .|  |  . . |  .| ..  .||  |  ..|. .|  | |.|..| ..
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 48-297 1.1e-47 157.7 In-house 39-284 (297) alignment 
Range on Protein: 48-297
Range on HMM: 39-284/297.0
KQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAerQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQiKCHL
. ...  .|.. |   .||... ||| ||. |.      . ||.||  |.  .   ..| || |  .||  || ||....  ...|||.. |... ||  
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPS--SPNAFLKFLQQVRDSGCLSRDVgPAVVHCSAGI
||...  .         ...|.|  ..  . |..| ...|  .... | | |.... |||  ..   | ...||....||..     .  | .|||.||.
yWsdkgvtt......fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGv

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
|| | .. .| ..  . .  | .. ...  ||  |. |.|| .|  | |.|..| .
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
0046845 (Phosphotyrosine protein) phosphatases II 49-299 1.3e-82 272.7 In-house 17-276 (284) alignment 
Range on Protein: 49-299
Range on HMM: 17-276/284.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLE-----RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQ
 .|.| . .  |. .|||.|. ||||||..||.     .. |||||..|.       . ....|.||||| .||..|| |||||..| . ||..|.|...
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

IKCHLYWPNEmGADKALKLphvkLTVELVRLETYQNFVRRWFKLTDLE-TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHC
.||. |||.| |  . ..     .||.|.. |.......|...||.|. |..||.|..||||.|||.|.|.||. .|.||..||..   . . || ||||
ekcaqYwple.gevltygd....ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC

SAGIGRSGTFCLVDCCLVLIDKYG---ECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|||.||.|||...|..| ...| |   ...| .... ||..|.| .|| .|. | |.|..| .|.
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 49-299 6.8e-67 220.5 In-house 30-278 (281) alignment 
Range on Protein: 49-299
Range on HMM: 30-278/281.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY
. ... |... |.  |||...  ||..|...    .  . |||||| |.  . |..|| ||||. ... .|| |||||| .|. |. . .|. ..||| |
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

WPNEMGadkalKLPHVKLTVELVRLETYQNFVRRWFKLtDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRS
||..       .|   ..||. .. |. .....| ||| . |. ..||| |..||.||| |.|......|.| ..|.     ...  | |.|||||.||.
WPddns.....elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrt

GTFCLVDCCLVLI-DKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
||.  .|  .  . ..  | .|. |. |||  |. ..||  | .| |.|... ..|
GtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 49-298 1.8e-60 199.2 In-house 9-265 (270) alignment 
Range on Protein: 49-298
Range on HMM: 9-265/270.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSV----DYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHL
. ...  |  ... ||||.|. |  ..|..|.. .      ||||| |.  . ....|| ..|||  |. .|| |.||.|..|..|. .|.|| . ||  
tsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer

YWPNEMGadKALKLPHVKLTVELVRLETYQNFVRRWFKLTdlETQQSREVMQFHYTTWPDFGIPSSPN------AFLKFLQQVRDSGCLSRDVGPAVVHC
|||.| .  . .|| . |..|  .  |  . ....  .|.  |. ..|... |.|.|||| |.|....        || |..|| |    .. .| .|||
YWpaepk..ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
|||.||.||. ..| .. |... ....| ... ||| .|| |.|. .|  | |.|..| ..
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPRA_pd Subfamily PTPRA 49-295 4.9e-60 198.1 In-house 47-293 (330) alignment 
Range on Protein: 49-295
Range on HMM: 47-293/330.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVLK--RG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY
| .   ...  |.  ||. .. |||.||..|   .|  . |||||  ..  .   ..| .|||. .||  || |.||||| ...|| .| |.|. ||. |
qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPNEmGAdkalkLPHVKLTVELVRLETYQNFVRRWFKLTD----LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgCLSRDVGPAVVHCSAG
||.| |.     . . ...||.   .  ...  | | ...     . ..|| | |||.|.|||.|.|. |   ||.|..|.   .  .  || |||||||
wPde.Gl.....vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk..lnqqsagpivvhcsaG

IGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
.||.|||. .|  |  .   .  .| ... .||  |  ..||  |  | |... |
vGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 50-291 9.8e-34 111.4 In-house 46-283 (305) alignment 
Range on Protein: 50-291
Range on HMM: 46-283/305.0
FSTSESErHTNRGLNRYRDVNPYDHSRIVLKRGS-VDYINANLVQLER-AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPN
| . .|  . .   |||.||   |.| . |.. | .||| || |      |...| .|||| .|. .|| || ..|   ..|| | .|  ..||  ||| 
fnanqsa.diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa

EMGADKALKLPHVKLTVELVRL-ETYQNFVRRWFKLTdLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGClsrdvgPAVVHCSAGIGRSGT
 .|  . ||   |   |   .  |   .     ..||    .|.  | ....| ||| |.|    . |..|  .| |        | ||||||||||.||
aqgeklelksgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv......pivvhcsagigrtgt

FCLVDCCLVLIDKYGECN-VSKVLCELRSYRMGLIQTADQLDFSYQ
   ..  |  | .  .|  . ...  ||  |   ||.  |  | ..
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihr
subfamily_PTPN13_pd Subfamily PTPN13 51-300 1.2e-73 242.8 In-house 28-272 (273) alignment 
Range on Protein: 51-300
Range on HMM: 28-272/273.0
STSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVdYINANLVQLE--RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE
........ |.  ||||.| |||..|. |.  .  ||||.|....    | .||..|||| .||  ||.||||||.. . |. .  ||...||| |||..
tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

MGadKALKLpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgcLSRDVGPAVVHCSAGIGRSGTFC
..  | ||. . .|.|||.... ...|| | ....|.|...||||.......||| |.|||.. .|.|...||    | .| || |||||||||||||. 
kn..kklkv.snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr...lqtdagPivvhcsaGiGrsGtli

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
 .|  | ||..  | .|.... .||  | |..|| ||  | |.||.| .|.|
tidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlksl
subfamily_ptpA1_pd Subfamily ptpA1 51-260 8.4e-37 121.9 In-house 38-259 (418) alignment 
Range on Protein: 51-260
Range on HMM: 38-259/418.0
STSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLErAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP
 ||| ... |   ||| .. | .|.|. ||.       |||||| ..     .|.| ||||| .|.  || ||||.. | ..||..  |. .|||  |||
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp

NEMGADKALKLP-----HVKLTVELVRL--ETYQNFVRRWFKLTdLEtQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG--C-LSR-DVGPAVV
...| ..              .|||| .  .  .. . |  .|| .|  ..|.. |..|  |||. ||   . | ..|. . .       |     | .|
eqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt.fe.getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGIGRSGTFCLVDCCLVLIDKY
|||||.||.||||     .  .|.|
hcsagvgrtgtfctavimmkkldhy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 51-297 3.3e-36 119.5 In-house 36-236 (392) alignment 
Range on Protein: 51-297
Range on HMM: 36-236/392.0
STSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKqikchlywp
 .. .... |   |||... ||| .|..|         ||.||  ..   .|. || .||| . ..  || ||....  .. |..|| |           
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

nemgadkalklphvkltvelvrletyqnfvrrwfkltdlETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVR-DSGCLSRdvgPAVVHCSAGIGRSG
                                         .. | | |||.| ||| ..|   ...|||...|. | |  ..   | ..|||||.||.|
.......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth...pliihcsagvgrtg

TFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
    .|. .    |    .| ... ..|  |  ..|| .|  | | |..| .
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0040439 (Phosphotyrosine protein) phosphatases II 52-297 1.1e-70 233.4 In-house 3-246 (249) alignment 
Range on Protein: 52-297
Range on HMM: 3-246/249.0
TSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPN
.|....  |. .|||.|. ||||||..|.        |||||... . .  |..|.||||| .||..|| |.||.......||..|.|....||. |||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

emgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTF
    .. |.  .  .||.|.. |.......| ..||.|....||.|....|| |||.|.|.|.. .|.|...||.     .. || .||||||.||.|||
....ggsleygd..ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

CLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
.. . .| ...|... ..  ....|||.|.| .|. .|. | |.|..| .
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 52-295 3.2e-40 132.7 In-house 32-291 (301) alignment 
Range on Protein: 52-295
Range on HMM: 32-291/301.0
TSESERHTNRGLNRYRDVNPYDHSRIVLKRGS------VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYW
.. . ...|. |||......||. ||.||  .       .||||. ..  . ....| .|||.  |.  || ..|..|  ...|. .| |... ||. ||
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

PNEMGADKALKLPHVKLTVEL-----------VRLETYQN--FVRRWFKLTDLEtqQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLSRDVGP
||    ..     .|.|. |            |...   |  .. | || .     .|..|.|.. | ||. |.   |.  |. ...|      . . ||
pnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrq.qkigggp

AVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 |||||....|||..| |.  |      |  .| .|   .|  ..| ..| .|  . |..| .
vvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
0045098 (Phosphotyrosine protein) phosphatases II 53-300 1.1e-71 236.7 In-house 26-275 (278) alignment 
Range on Protein: 53-300
Range on HMM: 26-275/278.0
SESERHTNRGLNRYRDVNPYDHSRIVlkrgsvDYINANLVQLEraERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNemgaD
... .  |. .|||.|. ||||||..      |||||....     ...|.||||| .|| .|| |.||.......||..|.|....||. |||.    .
tpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe....g

KALKLPHvkLTVELVRLETYQNFVRRWFKLTDL----ETQQSREVMQFHYTTWPDFGIPSSP--NAFLKFLQQVRDSGC------------LSRDvGPAV
. |   .  .||.|.  |...... |....|.|    |. .||.| ..||..|||.|.||.|  . ||..|...|.               |... || .
gsltygd..ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.gpvl

VHCSAGIGRSGTFCLVDCCLVLIdKyGECNVSKVLCELRSYRMG-LIQTADQLDFSYQAIIEGIKKL
||||||.||.||.......| |. . | ... ....||||.|.|  .|. .|. | |....| ....
VHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN9_pd Subfamily PTPN9 53-296 5.2e-67 221.0 In-house 35-289 (297) alignment 
Range on Protein: 53-296
Range on HMM: 35-289/297.0
SESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE
  |. ..|   ||| ||  ||..|.||..       |||||| |.  . .. .| |||||  ||  ||.|||||. . ..|  ...|....||  |||.|
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

MGAdkalKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDS-GCLSRDVG----------PAVVHC
 ..       ...|.|. |  |...... | ..... .|..||.|. | ...|||.|.||| ...|..|..||.  .......|          | ||||
ees....saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
||||||.|||. .| ||  ... | ..| ...  ||. |   ||| .|  | |.|..| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 53-298 4.1e-50 165.4 In-house 37-278 (315) alignment 
Range on Protein: 53-298
Range on HMM: 37-278/315.0
SESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE
  .  . |   |||... |.|..|..|    .    |||||  ..    .. || .||||  .|  || ||...|  .. |..|. |  .|||  |||..
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

MgADKAlklPHVKLTVELVRLETYQNFVRRwfKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgcLSRDVGPAVVHCSAGIGRSGTFC
  || .      .. |||. ||.  . | |  ||.  ....|| | ||..| ||| |..    ..||....|. .    ..  . .||||||.||.| ..
k.adsv...efGsikvellsleadtdgvar..klvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvi

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
 .| ..  | .    .| ... .||. |. |.|| ..  | |.|. | ..
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 53-292 1.7e-33 110.8 In-house 26-254 (267) alignment 
Range on Protein: 53-292
Range on HMM: 26-254/267.0
SESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKkQIkcHLYWPNEMGAD
| |  . |.  ||. |. |||..|..|.    .||||  |.  . ....|.||.||  |...|. .. .||   . .| |  .  .|  .|.|| .||  
sqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.ni..rlfwPPkmgqa

KALKlphvKLTVELvRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWpdfGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDC
|  .     ||||   ||  .|  .       .. . ...|  ..|  |    | .  . .|| |  .     |     | ||.||.|.||||||  .| 
kkyq....dltveh.slekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvids

CLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQA
 |  . . |  .. . | ..|| |.||..| ..  . .. 
qleraktegvsdifdflrkirsqriglvdtkeryiyihel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 53-130 1.8e-08 28.3 In-house 32-116 (347) alignment 
Range on Protein: 53-130
Range on HMM: 32-116/347.0
SESERHTNRglNRYRDVNPYDHSRIVLK-----RGSV----DYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLML
.| |.  ..  || .||.  | .|.||       .       ||||  .... |...||||| || |||  || ||   |   |. .
vewekslsk..nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0042113 (Phosphotyrosine protein) phosphatases II 54-296 4.6e-70 231.1 In-house 3-242 (245) alignment 
Range on Protein: 54-296
Range on HMM: 3-242/245.0
ESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNem
 ...  |. .|||.|. ||||.|..|.  .    .|||||..| . |  ...|.||||| .||..|| |.||.......||....|....||. |||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

gaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRSGTFCL
  .  |.  .  .||.|.. |.......| ...|.| . .||||...||. |||.|.|.... .|.||. ||.    ... || .||||||.||.|||..
..gesltygd..ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn.gpvlVHCsaGvgRtGtfia

VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
.. .| ...|... .. ... ||||.|.| .|| .|. | |.|..| 
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 55-297 9.8e-62 203.8 In-house 41-283 (305) alignment 
Range on Protein: 55-297
Range on HMM: 41-283/305.0
SERHTNRGLNRYRDVNPYDHSRIVLKR-GS---VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMG
 ....|.  ||.......|..|| |.   |    |||||. |.  . . .||..|||| .||  || ...| | . ..|| ||.| .. ||. |||....
gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

ADKALklphVKLTVELVRLETYQNFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVgPAVVHCSAGIGRSGTFCL
 .| .     ...|||   .|..... | .|..   | ..|| |.|.. |.||| |.| .. ..|.....|. .   ...| | .||||||.||.|.|. 
ekkef....gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv.pllVhCsagvgRtGvfia

VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
||  |  . | .. .| .|| .||| ||...|| || .| ..|. | |
vdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPRK_pd Subfamily PTPRK 55-296 1.5e-60 199.7 In-house 38-276 (314) alignment 
Range on Protein: 55-296
Range on HMM: 38-276/314.0
SERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMg
. .. ||  ||. |. .||.||..|.      | |||||.|.   .  ...| ||||| .||  || .|..... ...||..|.|. ..||  |||..  
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt.

adkalKLpHVKLTVELVRLETYQNFVRRWFKLTD--LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLsrDVGPAVVHCSAGIGRSGTFC
     .  . .. ||||. |. ...| | |...      .. ||| ||....|||...| | ...||....|  |     . |. ||||||| ||.|||.
.....ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfi

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
 .|  | .|.. |  .| ..  .|||... ...| .|  | |..|.| 
aidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 55-299 1.1e-58 193.5 In-house 4-244 (250) alignment 
Range on Protein: 55-299
Range on HMM: 4-244/250.0
SERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIkCHLYWPNEmg
...  |.  ||| |. ..|.||.||.. .     |||||  ..  . .. .| |||||..|. .|| ||.|.|| ...||..| |...  .| ||| |  
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..

adKALKLPHVklTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrDVGPAVVHCSAGIGRSGTFCLV
  || |  .|  ||.|   |.. ... | .||.  . ...| | |.|...||| |.|   .| |..|..|. |   . . .| .|.||||.||||.|. .
..kaekyGdv..tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiai

DCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|. |  . |    .| ||.  ||  |.. ... .|  | |..|.. .. 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 55-296 4.5e-46 152.6 In-house 20-254 (284) alignment 
Range on Protein: 55-296
Range on HMM: 20-254/284.0
SERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNklmekkQIKCHLYWPNEMG
..   |.  ||. .. ..|.... |.|       |||||  ..  . . .|| ||||| .|.  || |.||... ....|       . ||  |||... 
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

AdkalKLPHVKLTVELVRlETyQNFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCL
     |  . |. |..|  |. ...| | ..|..  . .. |.. |||.  ||| | | .|  .......||      ..  . |||||||.||.|..  
i....keerfkvkvdsve.es.eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
.|. |  ...    .| ... .||  |  |.|   |  | | |..| 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0037934 (Phosphotyrosine protein) phosphatases II 56-295 1.3e-66 220.0 In-house 6-240 (243) alignment 
Range on Protein: 56-295
Range on HMM: 6-240/243.0
ERHTNRGLNRYRDVNPYDHSRIVLkRGsVDYINANLVQLEraeRQYILTQGPLVDTVGH----FWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGA
 .  |.  |||.|. ||||||..|  |  |||||||..     ...|.||||| .|| .    || |.||.......||..|.|....||. |||.|.  
llpenlsknrysdilpydhsrvkl.eg.sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevty

DKalklphvkLTVELVRLETYQNFVRRWFKLTDLE-TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG-------CLSRDvGPAVVHCSAGIGR
..        .||.|.  |...... | ..|. |. ....|.|...||. |||.|.|.||. .|.||..||.         .|... || .||||||.||
gd........ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsaGvgR

SGTFCLVDCCLVLIdkygECNVSKVLCELRSYRMG-LIQTADQLDFSYQAIIE
.||... . .| |.    .... .....||. |.|  .|| .|. | |.|..|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 56-297 1.9e-48 160.2 In-house 44-288 (325) alignment 
Range on Protein: 56-297
Range on HMM: 44-288/325.0
ERHTNRGLNRYRDVNPYDHSRIVLK----RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQiKCHLYWPNEMGA
 .  |.  ||...| ..|.||.||.     .| |||||. .. ..    .. .| || .|.. .| .| . ..  |..||.| ..|. .|  |||.||| 
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkd.rcavywpkemgk

DKALKlphvKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRD-SGCL---SRDVGPAVVHCSAGIGRSGTF
 | .      | |.|. .|.. ..| | ... . .  ..| | ||.. .|.|.| .  | ... .|| |   | ..   ..  .| .||||||.||.|.|
sktfG....glevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

CLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  . . |  . .  . .. ...  ||  |  ...|.||  . |.|..| .
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 56-295 3.8e-42 139.1 In-house 29-264 (283) alignment 
Range on Protein: 56-295
Range on HMM: 29-264/283.0
ERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQL---ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAD
  . |.  ||.... |.|  |. ||  | |||||  . .   .. ...|| .|.|| .||  || ||...|  |..|| ||.| ..|||  |||..   |
sadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed

kalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQS-REVMQFHYTTWPDFGIPSSPNAFLKFlQQVRDSGcLSRDVGPAVVHCSAGIGRSGTFCLVD
      . ..|| | .  | . |... . |    . .|   .  . .  | ..|  .  |...||  .|.         || |||||.||||...|. . 
......yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislq.teskkgPivvhCstgiGrtavfiaas

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. .  .      .| .|.  .|  ||...|| ||  . .....|
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0049772 (Phosphotyrosine protein) phosphatases II 56-301 2.5e-38 128.0 In-house 42-284 (314) alignment 
Range on Protein: 56-301
Range on HMM: 42-284/314.0
ERHTNRGLNRYRDVNPYDhSRIVLKR---GSVDYINANLVQLEraeRQYILTQGPLVDTVGHF----------WLMV--WEQKSRAVLM-----------
    ||  ||| |. |.| .| .|..    ..|||||. |      ...| |||||  ||  |          | ||  .....| . |           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LNKLMEKKQIKCHLYWPNEMgadkalklphvkltvelvrletyqnF-------VrrwfkltdletqqSREVMQFHYTTWPDFGIPsSPNA
          |..|...  . .  ....                                   .             .|........ .||.. | ... 
rLdaAlgKtpllildgngneptaadlellk.........................eelydpelf.............erlgikylripvpDgsap.lled

FLKFLQQVRDSgclsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIdkygECNVSKVLCELRSYRM-----GLIQTADQLDFSYQAIIEGIKKLH
|..||. ...     .. || .|||.||.||.|||....... |      ... ..| ..|. |.     |.|.. .|. | ..|. | .|.|.
fdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 57-296 2.6e-53 176.0 In-house 46-278 (315) alignment 
Range on Protein: 57-296
Range on HMM: 46-278/315.0
RHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmgad
.  |.  ||| .. .||.||. |    .    ||.|||...    .|.|| .|||.| .|. || .|.|..   ..||..|.|... |.  |||..    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....

kalKLPHVKLTVELVRLETYQNFVRRWFklTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGIGRSGTFCLVDC
   |. . |.|| ..  | ....  | .  .    .. |||.|.|||.||| |.| .  ..... ..|.       .||. |||||||.||.|||. .|.
...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh..tnsvgaivvhcsaGvGrtGtfitlda

CLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
 |  ..     .| ...  .|. |....|.|.| .| |.|..| 
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 57-295 2.1e-41 136.7 In-house 4-238 (239) alignment 
Range on Protein: 57-295
Range on HMM: 4-238/239.0
RHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANL-VQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGa
.. |.  ||| ..  |||||.||.. |     |||||.   . . . . || ||| .  . | || |.|...   ..||  |.| .. ||| |||.    
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

dKalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLsRDVGPAVVHCSAGIGRSGTFCLVD
 |     ...| | | . | . ... | | ....   . | | |.|.| ||| |.|    | | . ...     |     | |.|||||.||.|.| ..|
.k.....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.l.pgarpwvihcsagvgrtgaflvid

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. |    |    .. . .  .|  |  ..||..|  | . |..|
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 57-295 2.7e-41 136.3 In-house 5-239 (239) alignment 
Range on Protein: 57-295
Range on HMM: 5-239/239.0
RHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANL-VQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGa
.. |.  ||| ..  |||||.||.. |     |||||.   . . . . || ||| .  . | || |.|...   ..||  |.| .. ||| |||.    
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

dKalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLsRDVGPAVVHCSAGIGRSGTFCLVD
 |     ...| | | . | . ... | | ....   . | | |.|.| ||| |.|    | | . ...     |     | |.|||||.||.|.| ..|
.k.....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.l.pgarpwvihcsagvgrtgaflvid

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. |    |    .. . .  .|  |  ..||..|  | . |..|
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 58-297 5.7e-51 168.2 In-house 45-278 (287) alignment 
Range on Protein: 58-297
Range on HMM: 45-278/287.0
HTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadkaLKL
  |. .||.... ..|  |..||    |||||  ..  . ....|....|...|.  || ......  |..|| ...|... .|. |||.|      . |
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks....vvl

phVKLTVELVRLETYQNFVRRWFKLTDLE-TQQSREVMQFHYTTWPDFG-IPSSPNAFLKFLQQVRDSgcLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
   . ..||.  |...... | ....  . ... ..|.|...|.|.. | ...    .| . ....      |  .. |||||...|||..|| ..  . 
..GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaattin

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  .. |  .| .|| . |  ..| .||..|  | .....| .
kckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 58-305 3e-37 123.3 In-house 39-285 (307) alignment 
Range on Protein: 58-305
Range on HMM: 39-285/307.0
HTNRGLNRYRDVNPYDHSRIVLKRG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKAL
..|   |||.||.  |..|||.|    . ||| || . .    ...| .|||| .|. .|| |. ..|  .|.|| |..|  .|||. ||| | |  .. 
santdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

KLPHVKLTVELVRLETYQNfVRRWFKLTDLE---TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdsgclsRDVGPAVVHCSAGIGRSGTFCLVDC
      ..|. .  ..         ..|.|.   .|.|| . .. .. ||| |.|    . . .|. ||       |  | |||||||.|||||   .  
geapntisvanlgakklap.dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr......ydtnpvvvhcsaGvGrsGtivaisl

CLVLIDKYGEC-NVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTF
    . .  .| .. |.. |||| |   |||  |  . .. ..|   .|.  |.
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelykety
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 58-295 1.6e-31 104.4 In-house 33-268 (285) alignment 
Range on Protein: 58-295
Range on HMM: 33-268/285.0
HTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLER-AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKALK
..|  |||| ||   . .|.|||    ||| |. ...    .  || ||||| .|.  || |....|   ||||  |.|    || ||.|...|  . .|
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg..evvk

LPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHY--TTWPDFGIPSSPNAFLKFLQQVRDSGClsrDVGPAVVHCSAGIGRSGTFCLVDCCL
. . ..|.  .. |.    .   . ... |   |  .   |     |||   |     .... . |.          | .||||||.||. ||  .| . 
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidyat

VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. | .  . ..  .. |.|. |.  .|.  |. | |  ..|
irimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 59-299 4.9e-57 188.1 In-house 27-270 (274) alignment 
Range on Protein: 59-299
Range on HMM: 27-270/274.0
TNRGLNRYRDVNPYDHSRIVLKRG-----SVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAD
 .   |||... | ..||..|..        .||||| ..  .. .. |. |||||. ||  ||.|....... ..|| || |... ||. |.|.. ...
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

KALKlpHVKLTVELVRLETYQNFVRRWFKLTDLETqqSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRD-VGPAVVHCSAGIGRSGTFCLVD
 . .  . .. .. .   . ...  | . |  ||   .|.|. . || |||   | ..|..|.....|..|   .   ..|.|||||||||| | |  ..
iser..ygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
 ..  ... .  .| |. |.||  | |..||..| .. ..|...  |.
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 59-297 6.8e-50 164.6 In-house 42-276 (515) alignment 
Range on Protein: 59-297
Range on HMM: 42-276/515.0
TNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKA
 |   |||... ||| .|. |         ||.||  ..   ... || .|||.  .|  || .|....  .. |..|| |  .|||  |||.  |  ..
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg..ds

LKLPHvkLTVELVRLETYQNFVRRWFKLtdLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRdvGPAVVHCSAGIGRSGTFCLVDCCL
.|. .  . |||| ||.  . ..| ...  |  ..|| | |||.| ||| |.|   ...||....|. .        | ..|||||.|| | .. .| ..
vkfGs..ikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvv

VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  . .    .| ...  .|  |. |.|| .|  | |.|. | .
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 59-294 1.2e-41 137.3 In-house 55-280 (290) alignment 
Range on Protein: 59-294
Range on HMM: 55-280/290.0
TNRGLNRYRDVNPYDHSRIVLKRGS-VDYINANLVQLERAerQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKALKL
|.   |||.||   | .|..|| |   ||. || |.  .|   .|||||.| |||  .| || ..|  |. || .|.|. . ||. |.|.. |  ..| .
tefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG..evltf

PHVKLTVELVRlETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgclsrdVGPAVVHCSAGIGRSGTFCLVDCCLVLI
 .. ..  .   .  .| ... . . | .. ..  .  ..  .|||  .. |  |.|. |. .|         || ||||||||||.|||  .. .| ..
Geitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqil

DKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAII
 .  | .. ..   ||  |.. .|   |     ....
ldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 59-298 4.9e-36 119.0 In-house 47-288 (305) alignment 
Range on Protein: 59-298
Range on HMM: 47-288/305.0
TNRGLNRYRDVNPYDHSRIVLKRG-SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKL
 ..| |||.||   |. |. |.     .|| || |      ...| || || .|   || | ...|  |..|| .|.||   ||. |.. . .    .. 
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

PHVKLTVELVRLETYQNFVRRWFKL--T----DLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgclsrdVGPAVVHCSAGIGRSGTFCLVD
   |..| .   .|..       |.  |    .   ...| | ..|.  ||| |.|.. .| |..|.. | |       || ||||||||||.|.  ...
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps......kgpivvhcsagigrtgsvvmle

CCL-VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
  |  |.      .  |.|  .|  |   ||| .|  | .| |.. ..
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 59-286 2.3e-31 103.5 In-house 36-258 (281) alignment 
Range on Protein: 59-286
Range on HMM: 36-258/281.0
TNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmgADK
 |   ||| ..   | ||. ||       | ||| || ..    .| |||||||  .|   || |.|.... |..|| ...| .. ||  |.| .  |  
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn..ahc

ALKLPhvKLTVELVRLETYQNFVRRWFKLTdlETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdsgclSRDvGPAVVHCSAGIGRSGTFCLVDCC
.|..   ||.|.       . .|   ..|.     ..| . .. .  |||. .| | . .|| |...|     .|   | |.|||||.|||||.  |. .
clqfd..klsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrkir.....ars.tppvihcsagvgrsgtlmaveia

LVLID-KYGECNVSKVLCELRS-YRMGLIQTADQL
|  |  ..   .. ...  ||   |   .|| .| 
lqsihshftlpdikqivshlrvtgraasvqtlqqy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-297 3.7e-24 79.9 In-house 46-279 (303) alignment 
Range on Protein: 59-297
Range on HMM: 46-279/303.0
TNRGLNRYRDVNPYDHSRIVLKRGSvdYINANLVQLERaERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmgaDKALKLP
.|   ||. ||   |||.. |   |  || |. ..|.  ... |||| ||  |   || |. ||| . ||.|    | ...  .  .|..   .  ||. 
knmdknrfvdvicldhskvklsdss..yihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn...qdflkfe

HVKLTV-ELVRLETYQNFVRRWFKLTDLETQQsrEVMQFHYTTWPDFGIPSS-PNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCC-LV
.  . | |. |.|  . .| .   ... . .    .   || .||   |||     |.| . |..       |  |.|    .| ||.|||.| . . | 
ersirvgefkrvelgdgwvlkvlsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
| ..    .. |.|  .|  |.  .|   |. . |  . | .
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 59-142 6e-08 26.5 In-house 33-119 (332) alignment 
Range on Protein: 59-142
Range on HMM: 33-119/332.0
TNRGLNRYRDVNPYDHSRIVL--KRGSVDYINANLVQLERAERQYILTQGPLVDTVG-HFWLMVWEQKSRAVLMLNKLMEKKQIKCH
 |  .||   .  .||||. |  . |  |. ||. |.    .  ||..| |. |     || || |.|   .|..  . ||.. |. 
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
0041856 (Phosphotyrosine protein) phosphatases II 60-297 2.8e-47 156.0 In-house 1-171 (182) alignment 
Range on Protein: 60-297
Range on HMM: 1-171/182.0
NRGLNRYRDVNPYDHSRivlkrgSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNklmekkqikCHLYWPnemgadkalklph
|. .|||.|. ||||||        |||||||.   .  ...|.||||| .|| .|. |..|.. .....|.         ..||||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

vkltvelvrletyqnfvrrwfkltdleTQQSREVMQFHYTTWPDFGIPSsPNAFLKFLQQVRDsgclsrDVGPAVVHCSAGIGRSGTFCLVDCCLVLidk
                           .   |...|..|. |||.|.|. .. .|.|...|..      . || .||||||.||.||... . ...|   
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl...

ygECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  .... ......||.|.| ..| .|. | ..|. | .
..gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 60-295 4.6e-47 155.2 In-house 3-237 (237) alignment 
Range on Protein: 60-295
Range on HMM: 3-237/237.0
NRGLNRYRDVNPYDHSRIVLKR--GSVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNemgADKAlk
|.  ||| ... |||||.|||   ...|||||. .. .. . ..|| .||||  .   || |||..|   ..||  |.|....||| |||.   .|.   
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps...tdqp..

LPHVKLTVELVRLETYQNFVRRWFKLTDLET-QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
 .. .||| | . | . ..  | . |.   | .. | . |...|.||| |.|    |.|.| ... .      . || ..|||||.||.| | ..|. | 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
   .    .. . .  .   |  .||| ||  | .|.|.|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 60-295 4e-29 96.5 In-house 43-269 (288) alignment 
Range on Protein: 60-295
Range on HMM: 43-269/288.0
NRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPh
|   .||...   | .|. |.  .  ||.||.|  .. .|. | .| ||  |.. .| |. |.  . ..||..|.|| . |   |.| ..|    ..   
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.

vkltVELVRLETyqNFVRRWFKLTDLETQQSREVMQ----FHYTTWPDFGIPSSPNAFLKFLQQVrdsgclSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
       |. .   . . .  |.. |  ..  |  .     |.  |.| |.| .  ..|..|. .           | |||.|||.||.||. |.   |.
....ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililiale

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 .       . ..| .||  |.  |||  |  . .. . |
slrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 60-299 1.7e-18 61.0 In-house 51-287 (302) alignment 
Range on Protein: 60-299
Range on HMM: 51-287/302.0
NRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTV---GHFWLMVWEQKSRAVLMLNKLMEKKQiKCHLYWPNEMGADKALK
|   |.  ||. .|. .. |.    .|.||  |..   .|. ||.| | ||..    .|| ||...|   | .| .  | |.   . ..|...|. |  .
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeyg

lphvKLTVELVRLETYQNFVrRWFKLTDLETQQSREVMQ--FHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvgPAVVHCSAGIGRSGTFCLVDCCL
    |. |   . |  .. .   . .  |    |  |.    . | |..  .| . ..  |  ..| ..   . .  ..|.    |.|| |.|  .   .
....kmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade..ntvivSknGaGRagafltlavav

VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  ..|  | |.. ..  .|| |   .....|  . | |..  |||
eklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
Y_phosphatase Protein-tyrosine phosphatase 61-295 2e-73 242.0 Pfam-A 2-235 (235) alignment 
Range on Protein: 61-295
Range on HMM: 2-235/235.0
RGLNRYRDVNPYDHSRIVL--KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAdkalKLP
.  |||.|. |||..|. |  . |. |||||| |.. . ....|.||||| .|...|| |||..|.... ||..|.||.. ||. |||.|..     .| 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slt

HVKLTVELV-RLE-TYQNFVRRWFKLTDLETQQ-SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
. ...|||. . .   .... | ..|.. .... .|||.|.|||.||| |.|.||...|.....|. |   . . || |||||||.||.|||...|..| 
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 ... .| .| ....|||. |.|..|...|. | |.||.|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 61-295 2e-73 242.0 In-house 2-235 (235) alignment 
Range on Protein: 61-295
Range on HMM: 2-235/235.0
RGLNRYRDVNPYDHSRIVL--KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAdkalKLP
.  |||.|. |||..|. |  . |. |||||| |.. . ....|.||||| .|...|| |||..|.... ||..|.||.. ||. |||.|..     .| 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slt

HVKLTVELV-RLE-TYQNFVRRWFKLTDLETQQ-SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
. ...|||. . .   .... | ..|.. .... .|||.|.|||.||| |.|.||...|.....|. |   . . || |||||||.||.|||...|..| 
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 ... .| .| ....|||. |.|..|...|. | |.||.|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-296 3.7e-27 89.8 In-house 44-275 (312) alignment 
Range on Protein: 61-296
Range on HMM: 44-275/312.0
RGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKaLKLpHV
. |||| ... .|  |. |      || ||.|..     ... ||||| .|. ||| ..    | ....|  ..|    ||  |  . .|  . |.  | 
kdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd.led.hr

KLTVELV----RLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdsgclsRDVGPAVVHCSAGIGRSGTFCLVDCCLVL
  |           . ..   | .|.    | |   . .. ...||| |.| | .. |..|  |.      .|  | . |||||.||.||..|..  .  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlaliesmiaa

IDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
. .    || ...  ||  |   ...  |  .. ....| 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 61-285 7.2e-24 78.9 In-house 53-278 (310) alignment 
Range on Protein: 61-285
Range on HMM: 53-278/310.0
RGLNRYRDVNPYDHSRIVLK---RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNeMGADKAL--
   ||| ||   | ||. ||       ||| || |. .     .| .||||  |.  || |...... ..|.| | .|. . ||  |||  .|  ..   
mhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygc

----KLPHVKLTVELVRLEtyQNFVRRWFKLTDLETQ-QSREVMQFHYTTWPDFGIPSSPN--AFLKFLQQVRDsgclsrdvGPAVVHCSAGIGRSGTFC
    .|       |.. |     ||     . .  .. .   |   ..  ||| |.|         ..| |||         || |||||||..| .. .
irvtnlsesseefeicnla..vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh........gpcvvhcsagkdrlyvvv

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQ
 ..  .  .|.  . .. .|  ||.  |.  |||  |
alklkidkldrglkvdaeevktellksraiciqtelq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 61-203 9.4e-11 35.8 In-house 97-232 (244) alignment 
Range on Protein: 61-203
Range on HMM: 97-232/244.0
RGLNRYRDVNPYDHSRIVLKRGSV--DYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQikchlYWPNEmgadKALKLP
   ||     |.| .|. | .||.   |||| .|       .||||| || ||   || |. |..   ...|  . |. .     |||.     . |.  
swknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpds....eplewy

HVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPD
   .|| |   . ..|     ...     .  . .  |  . || 
eeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps
subfamily_CG42327_pd Subfamily CG42327 63-223 3.1e-23 76.9 In-house 31-193 (319) alignment 
Range on Protein: 63-223
Range on HMM: 31-193/319.0
LNRYRDVNPYDHSRIVLKRG----SVDYINANLVQL-ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKL
 .|. .| |  ..|.||.|     .  |..|. |.  . |. .|| .| .| |.   || .||||.|| .. | .| |.   .|  |.| . . |     
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

PHVKLTveLVRLETYQNFVRRWFKLTDLETQQSREVMQFHYtTWPDFGIPSSPNAFLKFLQQVRDS
 ....|  |   |. ....   . |  .. ..|||.  . |  |.. ..|....|..  | .||.|
Gdilvt..lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 63-158 8.4e-20 65.8 In-house 50-163 (350) alignment 
Range on Protein: 63-158
Range on HMM: 50-163/350.0
LNRYRDVNPYDHSRIVLKR------------GSVDYINANLVQLER------AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY
 |||... ||.|||. ||.             . |||||| ..|.|      .. .|| ||.||  ||  |. .. . | . .|.|....|    ||. |
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPNEMGADKALKLP
|..    |. .|| 
Wqegsydditvkla
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 71-175 2.2e-07 25.3 In-house 4-95 (130) alignment 
Range on Protein: 71-175
Range on HMM: 4-95/130.0
PYDHSRIVlkrgSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQikchlYWPNEmgadKALKLPHVKLTVELVRLE
... ||.       .||||..| |    ..|.||| || ||  .|| |. |.    ...|  . |. .     |||.     . |.    ...| |   .
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpds....ePlewyeediivtltdrd

TYQNF
 ..| 
efkni
0044763 (Phosphotyrosine protein) phosphatases II 72-288 1.9e-28 94.7 In-house 2-162 (178) alignment 
Range on Protein: 72-288
Range on HMM: 2-162/178.0
YDHSRIVLKR----GSVDYINANLVQleraERqYILTQGPLvdtvGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadkalklphvkltvelv
.|..| .|       ..|||||. .     .. ..|.. |      ... ...|.. .....|.. .|  ..||. ||| |.|                 
ldrtrvllsnleglersdyinaseil....pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

rletyqnfvrrwfkltdletqqsrevMQFHYTTWPDFGIPSSPNAFLKFLQQVRD----SGclsrdvGPAVVHCSAGIGRSGTFCLVDCCLVLidkygEC
                          .|.... .||.| |...  ||.|.. ...    .|      || .||||||.|||||... . ...|      .
..........................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl.....gl

NVSKVLCELRSYRMgLIQTADQLDF
.. ... ..|..|.  ... .|| .
sleeaielvrerRp.ivpnpgqlrq
0046846 (Phosphotyrosine protein) phosphatases II 78-297 2.7e-41 136.6 In-house 6-173 (176) alignment 
Range on Protein: 78-297
Range on HMM: 6-173/176.0
VLKRGSVDYINANLVQLERaerqYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKalklphvkltvelvrletyqnfvr
   ....|||||||.   |    .| |||||..|. .|. |..|.. .||..|....|....||. ||| .....                         
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

rwfkltdletqqsrevmQFHYTTWPDFGIPSSpNAFLKFLQQVRDsgCLSRDvGPAVVHCSAGIGRSGTFCLVDcclvLIDKYGECNVSKVLCELRSYRM
                 |.... |||.|.|.. ...|..|...|.  .|... || .|||||||||.||... .    |. .    .| ..|...|..|.
.................qylhlpwpDhgvpdl.elllellefire..alkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-GLIQTADQLDFSYQAIIEGI
 | .|| .|. | |... . .
lgavqtpeQyrflyefellll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 81-310 6.3e-21 69.8 In-house 43-272 (290) alignment 
Range on Protein: 81-310
Range on HMM: 43-272/290.0
RGSVDYINANLVQLERaERQYILTQGPLVDT-------VGHFWLMVWEQKSRAVLMLNKLMEKKQI----KCHLYWPNEMGadKALKLPHVklTVELVRL
| . ||| || |.      . |||| |. ..       . .|| |. . |.. | || . .||..      |  | |...|  . ||.  .  ||.    
rfnddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg..eelkfkgl..tvkCksk

ETYQNFVRRWFKLTdLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGClsrdvgPAVVHCSAGIGRSGTFCLVDCCL-VLIDKYGECNVSKV
|. ... .|   ..  . ..   |    .  | .  .. ..  .|. .|.|. |.       |..|||  || || ..  ..     .... |. .. .|
ekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

LCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEE
| .||. |  .|..| .| |   .|.  ...  |... ...|
lkalrkqralaitsalelafvdagivllaievldqfaeeete
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 81-299 1.8e-18 61.1 In-house 58-290 (302) alignment 
Range on Protein: 81-299
Range on HMM: 58-290/302.0
RGSVDYINANLVQLERAerQYILTQG-----------------PLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADkaLKLPHVKLT
  . |.||||...|..   ..|..||                 |  .|.  .| .. . .   |  | ...|... ||  |. ...|    ||. .  ..
dfkndfinanvlkldei..kwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgge..lkfgrytvk

VELVRLETYQNFVRRWFKLTDLETQQSR-------EVMQFHYTTWPDFGIPSSPNAFLKFLQQvrdSGCLSRDVgpaVVHCSAGIGRSGTFCLVDCCLVL
   |. .  .   .. |||  .| . ..        |  .....||| | |  ... |. |.      .  ..|   .||||||.||.||.  .   . |
tvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkf...cesykknv...lvhcsaGvGrtGtlvaikyGiql

IDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  |   ... .... .|. | | .|...|| .    .  |. .
cskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme
0043147 (Phosphotyrosine protein) phosphatases II 84-291 4.2e-39 129.4 In-house 5-155 (172) alignment 
Range on Protein: 84-291
Range on HMM: 5-155/172.0
VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLmekkqikchlywpnemgadkalklphvkltvelvrletyqnfvrrwfklT
 |||||... | .  ...| |||||  |. .|| |..|.. .....|..|                                                 .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................l

DLETQQSREVMQFHYTTWPDFGIPsSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRSGTFCLVDCCLvlidkyGECNVSKVLCELRSYRMGLIQTA
 . .. .|...|..|. |||.| | ... .|.||.....  .||.. || .||||||.||.||... . .|        ... ......|. |.| .|. 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

DQLDFSYQ
.|. | |.
sqyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 84-294 3.3e-31 103.3 In-house 3-150 (151) alignment 
Range on Protein: 84-294
Range on HMM: 3-150/151.0
VDYINANLVQLEraerqYILTQGPlvdtVGHFWLMVWEQKSRAVLMLNKLMEKKqiKCHLYWPNEMgadkalklphvkltvelvrletyqnfvrrwfklt
.||||.. |        .....||      .|. ...|.. .....|....| .  .|. |.|..                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

dletqqsREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgclsRDVGPAVVHCSAGIGRSGTFCLVDCCLvlIDkygeCNVSKVLCELRSYRMGLIQTA
       .||...... |||.|.| |..|.|.||....|      . || .||||||.||.||.......|   .    ... ..| |.|..|.|..|. 
.......ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpn

DQLDFSYQAII
.|  | ..|..
qqflfqlfall
0051429 (Phosphotyrosine protein) phosphatases II 85-300 1.9e-42 141.1 In-house 5-228 (272) alignment 
Range on Protein: 85-300
Range on HMM: 5-228/272.0
DYINANLVQLERA---ERQYILTQGPLVDTVGHFWLMvWEQKSRAVLMLNKLMEKKQIKCHLYWP------NEMGADKALKLPHVKLTVELVRLETYQNF
.||||. |        .. .....|||  |. .|| . .|.. .....| ...|... ||..|||        .  | |    . .|.| |.  |.. ..
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VRRWFKLTDL-ETQQSREVMQFHYTTWPDFGIPSSPnaFLKFLQQVRDsgclsrdVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECN--------VS
. | . || |  ....||||..||| |||.|.|...  .|..|....|        || .||||||..|.||..... .|  ...   ..        . 
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

KVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
... |||..|.| .|| .|. | |.|..| ...|
eaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 85-290 1.3e-38 127.8 In-house 3-163 (174) alignment 
Range on Protein: 85-290
Range on HMM: 3-163/174.0
DYINANLVQLERAERQYILTQGPLVdtvghFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNemgadkalklphvkltvelvrletyqnfvrrwfkltd
|||||. . | .  . .|..||||      || |..|.....|.||....|..  ||. |||                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

LETQQSREVMQFHYTTWPDFGIPSSPNaFLKFLQQVRDSGCLsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDkYGECNVSKVLCELRSYRMGLIQTAD
| .  .|...|..|. |||.| |...  .|.|...|..      . || .||||||.||.||... . .|...   .  .. ... |||..|.| .|| .
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QLDFSY
|. | |
Qyrfly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 85-158 1.6e-10 34.9 In-house 91-166 (349) alignment 
Range on Protein: 85-158
Range on HMM: 91-166/349.0
DYINANLVQLER--AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLP
|||||| ..| |  .|..|| || ||  ||  |. ..  .. . || ||.  |.   ||. || .   ... .|| 
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 97-291 1.5e-17 58.5 In-house 3-198 (199) alignment 
Range on Protein: 97-291
Range on HMM: 3-198/199.0
AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE-MGADkalKLPHVKLTVELvrLETYQNFVRRWFKLTDLET--QQSREV
..|.|| || || .|.  || ||||  |  ..|.|    .|.    .|||    |.    |   . .|..   . |  ...   . ||.  |    .||.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttkt..ittkpdytitaliltnnttappstrei

MQFHYTTWPDFGIPSSpNAFLKFLQQVRDSGCL--SRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID--KYGECNVSKVLCELRSYRMGLIQTADQLDFS
 .. .|.| .   |     |. |.   |.           | .|||| | | .| |  .|  .   .  |    .. .|   ||  | |.| . .. .| 
shyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YQ
||
yq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 97-291 1.8e-17 58.2 In-house 2-197 (198) alignment 
Range on Protein: 97-291
Range on HMM: 2-197/198.0
AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE-MGADkalKLPHVKLTVELvrLETYQNFVRRWFKLTDLET--QQSREV
..|.|| || || .|.  || ||||  |  ..|.|    .|.    .|||    |.    |   . .|..   . |  ...   . ||.  |    .||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttkt..ittkpdytitaliltnnttappstrei

MQFHYTTWPDFGIPSSpNAFLKFLQQVRDSGCL--SRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID--KYGECNVSKVLCELRSYRMGLIQTADQLDFS
 .. .|.| .   |     |. |.   |.           | .|||| | | .| |  .|  .   .  |    .. .|   ||  | |.| . .. .| 
shyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YQ
||
yq
0049260 (Phosphotyrosine protein) phosphatases II 99-291 1.6e-34 114.2 In-house 9-144 (152) alignment 
Range on Protein: 99-291
Range on HMM: 9-144/152.0
RQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWpnemgadkalklphvkltvelvrletyqnfvrrwfkltdletqqsrevmQFHY
...| ||||.  |. .|| |..|.. ....||..|.|.. .||. |.                                                 |...
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qylh

TTWPDFGIPSSPNAFLKFLQQVRDSgcLSRDVGPAVVHCSAGIGRSGTFCLVDCCLvlidkyGECNVSKVLCELRSYRMGLIQTADQLDFSYQ
. |||.| |...  .| .|. ..    . .. || .||||||.||.||... . .|        ... ...  .|. |.| ... .|| | |.
lpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_hpo-7_pd Subfamily hpo-7 99-294 2.4e-19 64.2 In-house 38-224 (263) alignment 
Range on Protein: 99-294
Range on HMM: 38-224/263.0
RQYILtqgpLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMgaDKALKLPHVKLTVELVRLetyqNFVRRWFKLTD-LE-TQQSREVMQF
  |.|    ||.|.  |. ..  .|.  | ||    |. . ||  |.| |   |. .|| .|....  |      . . .  .|.  |.  .. ..| ..
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlek..dekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhy

HYTTWPDFGIPSSPNAFLKFLQQVRDSgclsRDVgpaVVHCSAGIGRSGTFCLVDCCLV----LID--KYGECNVSKVLCELRSYRMGLIQTADQLDFSY
 |. |..   |  ..  |. |. .|.|    ...   |||||.|||||  | ...         .|  . .| .  ..| |||| | . |.|  || || 
sykgWiekndpelareilnilkvarns....ksl...vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

QAII
  ..
lmvL
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 100-295 2.7e-20 67.5 In-house 36-219 (255) alignment 
Range on Protein: 100-295
Range on HMM: 36-219/255.0
QYILtqgplvdTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMgaDKALKLPHVKLTVELvrleTYQNFVRRWFKLTDLE--TQQSREVMQFH
 |.|       || .|. ..  .|.  | ||  . |... ||. |.| |   |. ||| .|..|.      . .. | |  ..|      .. ..|  ..
lysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek..deklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhys

YTTWPDFGIPSSPNAFLKFLQQVRDSgclsRDVgpaVVHCSAGIGRSGTFCLVDCCLV----LID--KYGECNVSKVLCELRSYRMGLIQTADQLDFSYQ
|. |..   |  ..  |. |. ||||    . |   |||||.||||| .| |..         .|  . .| .  ..| |||| | . |.|  || ||  
ykGWieknaPelareilnilkvvrds....ksv...vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil

AIIE
 ...
mvld
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 100-147 2.6e-06 21.0 In-house 237-281 (440) alignment 
Range on Protein: 100-147
Range on HMM: 237-281/440.0
QYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKkqiKCHLYWPN
 .| || ||  ||  || .| . .  ...|||.| .|    | .||| 
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
0048076 (Phosphotyrosine protein) phosphatases II 173-293 1.5e-25 85.0 In-house 27-139 (145) alignment 
Range on Protein: 173-293
Range on HMM: 27-139/145.0
QNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgCLSRDvGPAVVHCSAGIGRSGTFClvdcCLVLIDKYGeCNVSKVLCEL
.. ..... ||. ..  .|...|..|. |||.|.|.... .|.||.....  .|... || .||||||.||.||..    .. |. ..| ... ..| ..
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefiee..alkeg.gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelv

RSYRMGLIQTADQLDFSYQAI
||.|.| ... .|| | |...
rsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 183-288 8.1e-23 76.2 In-house 48-136 (144) alignment 
Range on Protein: 183-288
Range on HMM: 48-136/144.0
TdletqqsreVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgcLSRDvGPAVVHCSAGIGRSGTFCLVDCCLvlidKYGeCNVSKVLCELRSYRMGLIQT
.         ..|.... |||.|.|.... .|.||. ...   |... || .||||||.||.||... . ..    |.| ... ..| ..||.|.| ...
e.........giqylhlpwpDhgvpdllellleflefieea..leeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpn

ADQLDF
 .|| |
pgqlrf
PTEN_1 183-286 1.2e-07 26.7 In-house 75-182 (196) alignment 
Range on Protein: 183-286
Range on HMM: 75-182/196.0
TD---------LETQQSREVMQFHYTTWPDFGIPSSpNAFLKFLQQVrDSGCLSRD-VGPAVVHCSAGIGRSGTFClvdcCLVLIDKYGeCNVSKVLCEL
..          ...  .. ....   ..|.| ||  . ..... .. .. .||..  . ..||| ||.||||| .    .  |. |..  .. . |  .
seeeelsgrsydleeffksgveylhfpieDhgapsl.selfdicksf.iewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelv

RSYR-MGLIQTADQL
|. |  | .... | 
rekRppgapnspsqe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 185-298 1.4e-17 58.2 In-house 83-195 (440) alignment 
Range on Protein: 185-298
Range on HMM: 83-195/440.0
LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTAD
..  .|| . |.||  ||| |.|      ||..|.| .|   .   || .|||||| ||.|    ||. |    .  . ..  ..  .|. |  ..|| .
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QLDFSYQAIIEGIK
|  | ..|..||. 
qyafvheavlegll
subfamily_PTPDC1_pd Subfamily PTPDC1 186-288 5.4e-08 27.5 In-house 76-167 (182) alignment 
Range on Protein: 186-288
Range on HMM: 76-167/182.0
ETQQSREVMqFHYTTWPDFGIPSsPNAFLKFLqQVRDSGCLSRdvgPAVVHCSAGIGRSGTfcLVDCCLVLIDKYGecnVSKVLCELRSYRMGLIQTADQ
|  . .... ..  .|.|.| .|  .  |    .| .. .         ||| || || |   |. | ||  ...     .| .  .|| |   ||| .|
ealmeqgiy.vynfgwkDygvas.leriLdiv.kvvafalqeg...kvavhChaGlGrtGv..liacylvyakrlt...aekaiklvrskrpksiqtreq

LDF
...
vel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 188-258 4.8e-08 26.7 In-house 215-293 (349) alignment 
Range on Protein: 188-258
Range on HMM: 215-293/349.0
QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQqVR----DS----GCL-SRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID
..  |..|. .  |.| ..   | ..|. |. |.    |.      | . .. . .|||||| ||.|... .|  | .. 
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 192-293 3.6e-11 37.4 In-house 216-340 (350) alignment 
Range on Protein: 192-293
Range on HMM: 216-340/350.0
EVMQFHYTTWPDFGIPSSPNAFLKFLQ---QVRD-----SGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV-------LIDKYGEC--------NVSKV
.|.|...  |.| ..   |. .|. |.   .. |     |   .    | .||||||.|| ||.. .|  |        | ... .          .| .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LCELRSYRMGLIQTADQLDFSYQAI
. |||. |. ..|. ||  | |.|.
vnelrkqrismvqnldqfifiYeal
0038934 (Phosphotyrosine protein) phosphatases II 192-292 1.5e-09 33.3 In-house 78-172 (194) alignment 
Range on Protein: 192-292
Range on HMM: 78-172/194.0
EVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRSGTFClvdcCLVLIDKYGEcNVSKVLCELRSYRMGLIQTADQLDFSYQ
  ....   .||.| . | .  |.||. | .    . . |  .||| ||.||.||..    .  || ..|  .. . .  .|. | | |.. |.|.  ..
agieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAialfrekRpgaipnqdyleallk

A
 
r
PTPc_DSPc_SM00012 193-295 9.2e-32 104.8 In-house 2-105 (105) alignment 
Range on Protein: 193-295
Range on HMM: 2-105/105.0
VMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY-GECNVSKVLCELRSYRMGLIQTADQLDFSYQ
|...|||.|||.|.|......|..|..|...   | . .| |||||||.||.|||...|..|  ..|  .| .......|||..|.|..|| .|  | |.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AIIE
|..|
alle
subfamily_DSP23_pd Subfamily DSP23 194-288 1.3e-06 23.1 In-house 52-137 (148) alignment 
Range on Protein: 194-288
Range on HMM: 52-137/148.0
MQFHYTTWPDFgIPSSPNAFLKFLQQVRDSGCLSRDVGpavVHCSAGIGRSGTfcLVDCCLVLIDKygeCNVSKVLCELRSYRMGLIQTADQLDF
. ..    .|.  | ...   .|.. | ..   .  |.   |||  | ||.||  .. | ||   |      .. . |.|  | | ..| .| . 
ltlvrlriddy.hppaleqvvefvrvveeaeekneavs...vhcllgrgrtgt..mlacylvkerk...laaaeaiaevrrlrpgsvetveqekl
subfamily_CDKN3_pd Subfamily CDKN3 194-288 4.9e-06 20.2 In-house 100-187 (202) alignment 
Range on Protein: 194-288
Range on HMM: 100-187/202.0
MQFHYTTWPDFGIPSSPNaFLKFLQQVRDsgCLSRDVGpAVVHCSAGIGRSgtfCLVDCCLVL-IDKYgeCNVSKVLCELRSYR-MGLIQTADQLDF
.  |.   .| ..|.  .  ||.|...|   .|    . ..|||  |.|||   .||  ||.| .| .   .  . . .||  .  . |||  | ..
livhhypiadglvpdias.clkileelri..nlkayrk.tlvhcygglgrs...slviaclllylddt..iepkdaidklrdlkgsraiqtvkqyny
PTPc_motif_SM00404 211-250 9.8e-06 20.5 In-house 67-100 (140) alignment 
Range on Protein: 211-250
Range on HMM: 67-100/140.0
NAFLKFLQQVrdsgclSRDVGPAVVHCSAGIGRSGTFCLV
.. |.|....       .. |  .||| ||. ||.|....
dkvldfiena......ekkggkvlVHCqaGvSRSatliia
subfamily_CG42327_pd Subfamily CG42327 229-298 1.5e-08 28.7 In-house 246-316 (319) alignment 
Range on Protein: 229-298
Range on HMM: 246-316/319.0
DVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY-GECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
. || ||||| |.||.|.    |  .  ...     .. ...  .|  |   ..| .| .| |. . |  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 232-298 1.4e-10 35.6 In-house 230-296 (297) alignment 
Range on Protein: 232-298
Range on HMM: 230-296/297.0
PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
. .||||||.||||   | |  |  . |    .|  .|  ||. |  |.|| .| .. |.|... .|
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk
subfamily_eak_pd Subfamily eak 234-315 3.2e-07 24.0 In-house 240-322 (332) alignment 
Range on Protein: 234-315
Range on HMM: 240-322/332.0
VVHCSAGIGRSGTFCLVDCCLVLIDKYG--ECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHdPTFLDAEEPLISN
.. .. |  |.|.| ..|  . |||.       | ...   .| |.  . .| |  | |..... ... . . . | ...|.. 
iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn.nrlrdlkkyleay