Gene Pez in Drosophila melanogaster

Synonym: CG9493, Dmel\CG9493, PTPD1, dPez, Dmel_CG9493, Pez

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP041_AA protein Get Run
DmelP041_AA_965-1247 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 26-108 1.5e-20 63.3 Pfam-A 2-80 (80) alignment
Range on Protein: 26-108
Range on HMM: 2-80/80.0
HLLDTSsTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYlvkGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYV
.||| . ....|......|...|..||.|| ... |.|||..    .||..|..|.|....|..|...  .  ...|||..||
rlLDgt.vkevtvddsktgavlletVckrlglteteyFgLaf...kedkknesnwLdhdktlreqgveegkpttlllrvkfyv

FERM_M FERM central domain 114-230 9.3e-22 67.7 Pfam-A 4-126 (126) alignment
Range on Protein: 114-230
Range on HMM: 4-126/126.0
HLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQ-GDKQSKDYLKKSLV-------LPrnMQGLANDDSMLEGLIVEVLQQQAGIAH
...||... ....|.|.|..|.|. |.  .|.||| .  |.|.. ..  .|.|...|.|..        ||  ..   .  .  . |  ..|.. . .| 
pkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllp..vsprllkkekskqleqrileahknvag

LSQSQAEEMYIQCCQQLEGYGEERF
||...|. .|.|..|.|..|| . |
lslaeaklkylqaaqslpdyGvslF

FERM_C FERM C-terminal PH-like domain 236-317 6.4e-14 42.3 Pfam-A 3-85 (90) alignment
Range on Protein: 236-317
Range on HMM: 3-85/90.0
LGNDLLLGLAINGMVVNADNGRQ---YFPWKEFHTVTIDKRTIKIEQNKldGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRY
 |.|||||.. .|. .  .| .     |||.| . .. ..... |....     . | .| .|.........|| |..|..|.| 
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd..ekkkdvlkFyssqlrvnklllklcienhdlfrrr

E_Pc_C Enhancer of Polycomb C-terminus 354-409 8.6e-07 15.0 Pfam-A 3-56 (230) alignment
Range on Protein: 354-409
Range on HMM: 3-56/230.0
AAEQLQQHHQQQQHMQQQQ--QIQQQQMisSNISLATSANQMLgqSSSCLDLSNNNLH
 ||| ||| .|  .||.||  |.||.|.  .. | |..|.| |   |  ||    .  
taEqyqqHqeqLvlmqkqqlaqlqqkql..qqnssaatatqal..vsktlDsAsAqFA

0050432 (Phosphotyrosine protein) phosphatases II 960-1248 5.1e-62 205.3 In-house 21-301 (308) alignment
Range on Protein: 960-1248
Range on HMM: 21-301/308.0
PISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLtpcrDNRHGYVNASSISATVGTKQRFYIVAQSP
..| ..| ..|...|...|. ..|..|||....  ..  |..|||.|| .||  ...|||| .||.|    |. ..|.||| ..  .  ..| .|..|.|
vsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgP

QEPlTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSH-QRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRD
 .  |.  ||. ||| .| ..| ||. .         | | . . . ||.|.|.|.    .. | .|. .|.| .. .  .| |. ..| .| ....| .
lpn.tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

VNHFLDFLEELNSVRlastqevppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
....|||||......             ..|.. ||  | ||.|. ...||||  |...  .|.. .. .||.||   .... ||.|.| .|. |||.
peilldflelvrksl............pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

subfamily_PTPN14_pd Subfamily PTPN14 961-1250 1.7e-135 445.8 In-house 3-300 (300) alignment
Range on Protein: 961-1250
Range on HMM: 3-300/300.0
ISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQ
...|..|||...||..||.....|.|.|||||.||.||...| |.||..||.....|||.||||.|.|...|..||.|||||...||.|.|.|||||.|.
eatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl

ePLTMRIFWQCVWEADVYLVVQLTED--------MSYIPRN--SHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRD
 .||...|||.|||..|.|.|.|||.        ..|.|..  .....|||.|.|...||...|...|..|.|.|.||...|.||.|||.||.....|.|
.eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeD

VNHFLDFLEELNSVRLASTQEVPPgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR
|..||..|||..||| ....||.. ....||||.||..|.||.||....|||..||.|||..||..|...||.||......||||||.|..||.|||..|
vkgflsyLeevqsvrrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr





0039614 (Phosphotyrosine protein) phosphatases II 967-1249 1.8e-54 180.6 In-house 18-292 (297) alignment
Range on Protein: 967-1249
Range on HMM: 18-292/297.0
KDKLCQILDQKLSDSQLFMEFERIPKRREHalYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSIsaTVGTK-QRFYIVAQSPQEPl
   |.. |....| ..|..|||....  .   |..|||.|| .||  ...||||..||.|.|...  . . |.||| .  ..  . .| .|..| |..  
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpe.

TMRIFWQCVWEADVYLVVQLTEDM-------SYIPRNSHqrlEFGQFQVYQEFSQTTDRCTTIKLRLYHvpSRRYRSVWYLQYADWAEQNCPRDVNHFLD
|.  ||. ||| .|  .| ||. .       .| | ..    ..|.|.|.    .. | .|. .|.. .  .   | |. .|| .| . ..| .....|.
tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellle

FLEELNSVRLAStqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
|||...... ..        . . ||| ||  | ||.|. ..|.|.|. |... ..|.. .. .|| ||  ..... ||.|.|..|. .|||.
flelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 971-1247 2.9e-33 110.3 In-house 11-284 (305) alignment
Range on Protein: 971-1247
Range on HMM: 11-284/305.0
CQILDQKLSDSQ-LFMEFERIPKRREHAlyECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIF
..| ...  ... | .... .... |    .    |.|. ||.  .  ..||.|..||.  ..  . |.||| . .    ..  |||||.| .  |.. |
ayikearvysdkgleaqykslyeeeesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy..krkkkyivaqgPlkn.tvadf

WQCVWEADVYLVVQLT----ED----MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLE
|. ..|  |  .|.||    ..      | | .  .. |||.|.|  . ..|.   .. ||..     ..  |.|  .|  || ..  |.    .|....
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

ELNSVRlastqEvppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
...  .     .    .. . |.| || .| ||.|| .. |. |  | . | .|. .|. |||..|  .. .|.|| |... |  ...
rvqkdq.....k....kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

0036941 (Phosphotyrosine protein) phosphatases II 972-1250 1.6e-60 200.3 In-house 4-281 (297) alignment
Range on Protein: 972-1250
Range on HMM: 4-281/297.0
QILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLtpcRDNRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQC
..|...|. ..|  |||.....     ...|||.|| .||. ...||||..||.|    |. ..|.||| .  ..   .| .|..| |..  |.  ||..
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpn.tvedFWrm

VWEADVYLVVQLTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQT--TDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
||| .|  .| |||...        | | .  . |..|.|.|     ..   | .|. .|..... .   | |....| .| . ..| .....|||.|..
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

NSVRLAStqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD---HNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR
..|. ..        . ..||| ||  | ||||. ..|||.|. |.   ... .||. .. .||.||  ....| ||.|.| .|. .||...
rkvlkll........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0047943 (Phosphotyrosine protein) phosphatases II 972-1246 7.3e-57 188.3 In-house 3-272 (273) alignment
Range on Protein: 972-1246
Range on HMM: 3-272/273.0
QILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLtpcRDNRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQC
..|...|. ..|..|||....  ..  |..|||.||  ||  ...||||..||.|    |. ..|.||| .  ..  ..| .|..| | .  |.  ||..
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpn.tvedfwrm

VWEADVYLVVQLTEDMS--------YIPRNSHQ-RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELN
||| .| ..| |||...        | | .  .  |..|.|.|.    .| | .|. .|.|... .  .| |....| .| ....| .....|.|.|...
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

SVRLASTQEvppghntnPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
... |. ..        .||. ||  | ||.|. ...||||. | ..  .|.. .. .|| ||  ..... ||.|.|..|. ||
kalealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPN3_pd Subfamily PTPN3 972-1243 1.7e-44 146.9 In-house 6-272 (280) alignment
Range on Protein: 972-1243
Range on HMM: 6-272/280.0
QILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTpcrDNRHGYVNASSISATVGTKQRF--YIVAQSPQEpLTMRIFW
. | . |.  .....||.. ....    ..| . || .||   . ||||. ||.|.   ...  |.||. ..  . ...    ||..| | .  |.  ||
lllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...esetdyinanyvnmeipstglvnryiatqGPla.ktatdfW

QCVWEADVYLVVQLTEDM--------SYIPRnSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
| ||| .. |.| ||. .         | |. ....||.|.|.|. | ...|  . . .| | .  ... |..  ||| .|.... | | ..||.|.|..
qmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

NSVRlastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
...|          . .. ||..||  | ||.|| .. .. |  ....|.. .. .. ..| || ..... .||||. . ..
rklr..........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_PTPRA_pd Subfamily PTPRA 974-1245 2.4e-28 94.0 In-house 23-294 (330) alignment
Range on Protein: 974-1245
Range on HMM: 23-294/330.0
LDQK-LSDSQLF-MEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQ
....   |..||  ||. .|  . .| .| |  |||. ||  .| |||| .|| |.. . .    |.||| |      ..  .| || |.|  |.  ||.
irirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy..kekdkfiaaqGPkee.tvedfwr

CVWEADVYLVVQLTEDMSYIPRNSH------QRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRR----YRSVWYLQYADWAEQNCPRDVNHFLDFLEE
 .|| .   .| |||         .        . .|. .|  | .. .   |  |. . ..|  .     | |  . .  | .   | .    |..|..
miweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk

LNSVRlasTQevppghNTNpPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
.....    |      ... |. .||  | ||.|  .. | .|  .  .. .|. ... .|| ||  .. .. ||.|||. |  |
vkkln...qq......sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPN6_pd Subfamily PTPN6 975-1249 8.1e-40 131.7 In-house 20-300 (306) alignment
Range on Protein: 975-1249
Range on HMM: 20-300/306.0
DQKLSDSQLFMEFERIPKRREHALYE--CALLEENEPKNHDPNFLPYDDNRVRLTpcRDNRHG--YVNASSISATVGTKQRFYIVAQSPQePLTMRIFWQ
...|. . .  |||.. .. .. |..   .   ||. ||   | ||.|..|| |.  ...  |  |.||. |.  | .... || .|    . |.  ||.
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgcl.ettvsdFWr

CVWEADVYLVVQLTEDM--------SYIPRNSHQRLeFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
 ||. .  ..| .|...         | | .....  .|. .| .  ...... .  .|.. .   ... |.|. ... .| ....|.| ...|||||..
mvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

NSVRLASTQEvppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDH---NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
|. .  ....      .. |.. || .| || |  .  |.|| .. .   . |.|| ... ..|.||  ..   .||||.|. . .|....
nrkqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk

subfamily_PTPN13_pd Subfamily PTPN13 975-1248 3.5e-36 119.9 In-house 5-271 (273) alignment
Range on Protein: 975-1248
Range on HMM: 5-271/273.0
DQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTpcrdNRHGYVNASSISATVGTKQRFYIVAQSPQePLTMRIFWQCVWE
 .|| . |   ||. . . .     | .  .||. ||   | ||||. ||.|     .  ||.||| | ..|| ..  ||..| |  | |.. ||| |||
qkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....deggyinaslikvpvgkdeyeyiacqGPl.Petvkdfwqmvwe

ADVYLVVQLTEDM--------SYIPRNSHQRLEFGQ-FQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVr
 .. ... .| .          | | . ...|   . ..| ..  |  |  .  .| . .. |.. | |  |....| . . |.  ...| |. |.... 
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl.

lastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
          .. . |.. ||  | ||||. .| | .|  .......|.  .. .||.||.... .  || |.|. ... ||.
..........qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 976-1247 1.1e-34 115.0 In-house 22-291 (298) alignment
Range on Protein: 976-1247
Range on HMM: 22-291/298.0
QKLSDSQLFMEFERIPKRRE---HALYECALLEENEPKNHDPNFLPYDDNRVRLTP-CRDNRHGYVNASSISATVGTKqrFYIVAQSPQEPlTMRIFWQC
.| . ... .||.|. .  .   .. .| |  .||. ||  .. ...|  ||.|.    |.   |.||| ..|  |..   .|..| | .. |.  ||. 
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPlte.tvedFWrm

VWEADVYLVVQLTE--D------MSYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElns
|.| |.  .| ||.  .        | |   ..  ..|...|    ...    .. || . .  ... |.|  |..  |...  |.  .  ||.|..   
vteedigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk...

VRLaSTQEvppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
||  |.|.     . | ||...| .| ||||     | .|  . ... .|. .|.  ||..|  .. . .||.|||.. . .|.
vra.sqqq.....agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 976-1247 4.2e-34 113.0 In-house 19-284 (319) alignment
Range on Protein: 976-1247
Range on HMM: 19-284/319.0
QkLSDSQLFMEFERIPKRREHaLYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWE
.  .. .|  ||. . .  .   .. |  |||..||  .| |.||  || |..  .     |.||| | .    ... .| .|.| |  |.  ||. |||
s.tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlen.tiedfWrmvWe

ADVYLVVQLTEDMSYIPRNSHQR------LEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRR-YRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlA
 ... || ||..   .  . ..        |.|.. |  |  . ..     || | .  |    |.|   || .|.... |..    ||.|....    .
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk...s

STQevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
  .      ... |.  || .| || |  .. |  |  . ... ||.  .. .|| ||. ..   .||||||. |. ...
rek......tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 976-1248 4.9e-18 59.6 In-house 21-287 (302) alignment
Range on Protein: 976-1248
Range on HMM: 21-287/302.0
QKLSDSQLFMEFERIPKRREHaLYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNrhgYVNASSIsaTVGTKQRFYIVAQSPQEPLT--MRIFWQCVW
..|  ...  ||..| . . . | .| .  .|  ||. ...  .|.|.|.|. . |.   |||||..  .|   .|  |.|| |.   .  .  ||. |.
ksldtaevkkefkkidtmkvd.lekCkafkknlkknqsedvpildsnlvkleaepds...yvnaskv..evPeltrsiilaQlpkvdsedsveeFWrmvf

EADVYLVVQ--LTEDM-----SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTtIKLRLYHVPSRRYRSVWYLQ--YADWAEQNCPRDVNHFLdflEELNSV
.  .  ||    .|..      ..|..| . .|.|.. | .   . ..  .  .. .  .|     ||         | ... |  ...     ..  .|
qekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli...ktaakv

rLASTqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
  |..       ... ....   .| || |. ||. . . .|.....  |  .. ..| || ... || || ..|  |..|.|.
.fakk......ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 976-1245 2.1e-14 47.9 In-house 6-268 (281) alignment
Range on Protein: 976-1245
Range on HMM: 6-268/281.0
QKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTP--CRDNRHGYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVW
||..  ..  ||  .|      |  .     |. ||.  |    |  ||.|       |   |. |  | . .   .| ||..| |..  |   ||. .|
qkmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkke.tradfwrmiw

EADVY---LVVQLTED-----MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYlqYADWAEQNCPRDVNHFLDFLEelnSVR
. .     ...|..|        |.|||.|  |.| .. |  | |       | .| | .    |  . |   . .| . . |   . .|  |     .|
qenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwl..wkewpdwqvpessevmlkilr...kir

LASTqevppghntnPPVlLHCLEGGGRSGVTLTADLLLYTLD-HNEDLDIPRVIGQLRH-QRDSIIPSLAQYKFIYNLLITY
  ||          ||| .||  | ||||  .. .. | ..  |    || ... .||   | . . .| || .|...|. .
arst..........ppv.ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0040438 (Phosphotyrosine protein) phosphatases II 977-1249 4.1e-57 189.2 In-house 15-279 (317) alignment
Range on Protein: 977-1249
Range on HMM: 15-279/317.0
KLSdSQLFMEFERIPKRREHaLYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSIsaTVGTKQRFYIVAQSPQePLTMRIFWQCVWEA
.    .|  |||....   .  |..|.|.|| .||. |..||||..||.|.|.   . ..|.||| .  ..  ..| .|..|.|. | |.  ||..||| 
sdf.talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPl.pntvedFwrmvweq

DVYLVVQLTEDM--------SYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRla
.| ..| ||| .         | |    . |..|.|.|     .. . .|  .|....  .   | |. ..| .| ....| . ...|||||......  
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal..

stqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
         . . ||| ||  | ||.|. ..|.|.|. |......|.. .. .||.||  ......||.|.| .|. ||||.
........edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0045098 (Phosphotyrosine protein) phosphatases II 977-1248 6.2e-51 168.8 In-house 3-274 (278) alignment
Range on Protein: 977-1248
Range on HMM: 3-274/278.0
KLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRltpcrdnrhGYVNASSISATvgtkQRFYIVAQSPQEPlTMRIFWQCVWEAD
.|....|..|||...       ...||...| .||  ...|||| .||.         .|.||| |.      .. .|..| | .  |.  ||...|| .
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy....pkkfIatqgPlps.tvadfwrmlwelg

VYLVVQLTED--------MSYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV----PSRRYRSVWYLQYADWAEQNCPRDV--NHFLDFLEELN
.  .| |||           | |   .. |..|.|.|. .  ...|  |...|.....    ..   | |..|.|  | . ..| .   ..||..||...
itvivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

SVRLASTQEVPPGHN---TNPPVLLHCLEGGGRSGVTLTADLLLYTLdhNEDLDIPRVIGQLRHQRDS-IIPSLAQYKFIYNLLITYLKR
... .  . .   ..    . ||| ||  | ||.|.   |.|.|. |  .. .|.. .. .|| ||   ....| ||.|.| .|. .|.|
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_PTPRB_pd Subfamily PTPRB 977-1248 5.2e-35 115.9 In-house 21-287 (293) alignment
Range on Protein: 977-1248
Range on HMM: 21-287/293.0
KLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEA
. || ..  |.|.. .  ..   ..| |..|. ||   | |||| .||.|.. .|..   |.||. |.    . .| .|..| |  | |.  ||. ||| 
adsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy..nsprefiatqGPl.petvddfWrmvwek

DVYLVVQLTEDM--------SYIPRNShQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHvpSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRla
 .  .| ||. .         | |... .   .|. .|    .....  .. .|.. .  ... |.|  ...  |.. . | . . .|||.......   
kssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai..

sTQevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 ..     .... |.. ||  | ||.|. .. | || ...... .||  .. .||..| ... . .|| ||.. ....|..
.ek.....taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_PTPRD_pd Subfamily PTPRD 978-1247 1.2e-41 138.0 In-house 20-282 (564) alignment
Range on Protein: 978-1247
Range on HMM: 20-282/564.0
LSDSQLFMEFERIPKRrEHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVWEAD
 || ....|...| .. ..   | |  ..| .||   | ..|| .||.|.. .  .   |.||| | .    |.. || .| | .. |.. ||. ||| .
nsdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlae.tiedFWRmvweqn

VYLVVQLTEDM--------SYIPRNsHqRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlAs
.  .| ||.          .| | . . . ..|...|  | ...    .  ...| .  |.  | |   .. .| ... |   ...||.... ....   
sstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.

tqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
        ... |.. ||  | ||.|. .. | .|  . .....||  .. .||.||. .. .  || ||.. .  .|.
........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

0043336 (Phosphotyrosine protein) phosphatases II 979-1246 1.2e-51 171.2 In-house 18-277 (278) alignment
Range on Protein: 979-1246
Range on HMM: 18-277/278.0
SDSQLFMEFERIPKRREhALYECALLEENEPKNHDPNFLPYDDNRVRLTPCR-DNRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQCVWEADV
. . |  |||....      |..|||.|| .||  ...|||| .||.|...  |. ..|.||| .  ..  ..| .|..| |..  |.  ||. ||| .|
lktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpe.tvedFwrmvwelgv

YLVVQLTEDM--------SYIPrnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlast
  .| |||..         | |    . |..|.|.|.    .. | .|...|.. .  .  .| |. ..| .| ....| .....||||.......    
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal....

qevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
      .. | ||| ||  | ||.|. ....|||. |...  .|.. .. .||.|| ...... ||.|.|..|. ||
......edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Ptp69D_pd Subfamily Ptp69D 979-1248 1.6e-36 121.0 In-house 20-288 (307) alignment
Range on Protein: 979-1248
Range on HMM: 20-288/307.0
SDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCR-DNRHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADV
.|  |  |.|....|  .   . .  .||  ||  ..  ..|..||.|..   ..   |.||| | .    ... .|.|| | |  |.  ||. ..| .|
tdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPve.atigDfWRmiaeqev

YLVVQLTEDMSYIP----RN--SHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-----SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL
.|.| |..   .      .     .  ..|.  |    .....  .  .| . ..          | |   .|  | . . |.  .  |...|.....  
tlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

AStqevppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 .          . |...||  | ||||. .. |.||  |  .. .||  .. .||.||. .. ||.||.|.|  |. | . 
ln..........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 979-1057 4.3e-06 20.8 In-house 21-94 (95) alignment
Range on Protein: 979-1057
Range on HMM: 21-94/95.0
SDSQLFMEFERIPKRrEHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNrhGYVNASSISATvgTKQRFYIVAQ
|| ..  ||  |.     | | .   | | |||   | .|||  || ||  ||    |.||  .     ...  || ||
sdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlttkrds..dyinacfvdgy..arkncyiaaq

0051299 (Phosphotyrosine protein) phosphatases II 980-1247 5.5e-57 188.8 In-house 22-287 (288) alignment
Range on Protein: 980-1247
Range on HMM: 22-287/288.0
DSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQCVWEADVY
 ..|..|||....  ..  . .|||.|| .||  ...||||..||.|..  . . ..|.||| |  ..  ..| .|..| | .  |.  ||. ||| .| 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrkfIatqgPlpn.tvedFWrmvweqnvr

LVVQLTEDM--------SYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV----PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL
..| ||. .         | |   .. |..|...|.    .. | .|. .|.. ..    ..  .| |. ..| .| ....| .....||||....... 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

astqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
          ....||. ||  | ||.|. ...||||. |.... .|..... .||.||  ..... ||.|.| .|. |||
..........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk

0045450 (Phosphotyrosine protein) phosphatases II 980-1247 9.8e-54 178.5 In-house 26-305 (307) alignment
Range on Protein: 980-1247
Range on HMM: 26-305/307.0
DSQLFMEFERIPKRRE--HALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSISA------TVGTKQRFYIVAQSPQEPlTMRIFW
 . |. |||....        |..|||.|| .||  ...||||..||.|... .  . ..|.||| .         .  ..| .|..|.|..  |.  ||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.tvedFw

QCVWEADVYLVVQLTEDM--------SYIPRNsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV-PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEE
. .|| .| ..| |||..         | | .  . |..|.|.|.    .. | .|  .|.. .  ..   | |....| .| ....| .....|||.||
rmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

LNSVRLAstqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNED---LDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
..... .        .. . ||| ||  | ||.|. ..|.|.|. |....    .|.. .. .|| ||  ..... ||.|.|..|. .|.
vrkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 980-1247 1.9e-35 117.5 In-house 19-281 (318) alignment
Range on Protein: 980-1247
Range on HMM: 19-281/318.0
DSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVY
. .|. |.||. . .|..    .| . |. ||   | |.||. ||.|..  ..    |.||. |     .... || ||.|  | |.. ||. ||| .  
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy..rrkkayiaaqaPl.petieDfWrmvWeqnsa

LVVQLTEDMSYIPRNS------HQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqev
..| ||. .    .        ..  ..|. .|  . . ...  .  .... .  .   | |   .|..|.... | .. ..||.. . ... . |    
vivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqks....

ppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
     .. |.. ||  | || || .. | ||  . ... .|.  .. |||.||. ..    ||.|||. |. .|.
.....gagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 980-1243 4.9e-31 103.2 In-house 33-288 (319) alignment
Range on Protein: 980-1243
Range on HMM: 33-288/319.0
DSQLFMEFERIPKRRE-HALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADV
 ..| .|| |..|.    |  . | |..|  ||   | |..| |.|.| .        |.||| ..     ..  || || |. . |.  ||. .|| ..
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy..qrkdkyiaaqGPl.dntladfWrmiweync

YLVVQLTEDMS--YIPRNSHqrLEFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFleeLNSVRLASTQEvpp
  .| ||.|.   | | .     . ..|.|  .  . |.  .  ...| .    .  |..    .  | ..  |     .. .   .. ||   ..|   
stivlltkdkcsqywplkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl...vkkvrhltske...

ghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
  | . ....||  | ||.|| .. | ||  ..... .|. ... .|| ||. .. .|.||||||  |.
..nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_PTPRG_pd Subfamily PTPRG 980-1246 4.4e-29 96.1 In-house 18-287 (563) alignment
Range on Protein: 980-1246
Range on HMM: 18-287/563.0
DSQLFMEFERIPKRREH--ALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEA
|  .  ||| . ..  .    .| .  .||  || . | ..||  ||.|.|  .  ... |.||. |      |.. .|..| |  . |.  ||. .|| 
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy..qkskafiatqgpl.kdtfddFWrmiWeq

DVYLVVQLTE--------DMSYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-----S-RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
 | ..| .|.           | |.   . ...|..|| .. ....   |. .| . ..      .    . |   .|..| ... |      | | .  
nvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

nsvrlaSTQEvppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
      |. .    ...  |.. || .|.||.|. .  | ||  . ...  .. ... ..| ||. .. .  || |... |.  .
......saan....kaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 981-1249 1.5e-37 124.3 In-house 15-279 (281) alignment
Range on Protein: 981-1249
Range on HMM: 15-279/281.0
SQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATVGTKQrfYIVAQSPQePLTMRIFWQCVWEADVYL
. . .|.| . .   .   . .  .||  ||   |   ||  ||..||  .|    |.||. ...  | |.  ||..|.|  | .. .||| ||| .| .
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPv.PaslvafWqmvweqkvsa

VVQLTEDMS--------YIPrNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLyHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLastqe
.| .|...         | | . ...|..|...| .. .... .  . |..| .  |   |.|  |.|  | ..  | . ...|.| .|.....      
ivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklte.....

vppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD-HNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
    ..|. |...||  | ||.|. .. | |. ... ..|.||.  |. .||..|  .. ...||.|.|  .. .|...
....kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_PTPN9_pd Subfamily PTPN9 981-1248 2.2e-31 104.0 In-house 16-292 (297) alignment
Range on Protein: 981-1248
Range on HMM: 16-292/297.0
SQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
. |  |.. | ..  .  .... |  |  ||   . | ||. || |.   ..    |.||. .      ... .| .| |  . |.. ||. ||| .|  
rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy..kqkkafiatqGpl.kktvsdfWrmvWeqevlv

VVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQE
.|  |  .         | | ..... |||...| .   ....  .. .| ...|  .. |.| . |.  | .   |.. . .||.||.  . . ....|
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke

VPP---GHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
. .   || ..||...||  | ||.|   | |. |  |.. . .|.  .. .|| ||   |    ||.| |  .. | ..
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 981-1250 1.2e-29 98.3 In-house 5-272 (274) alignment
Range on Protein: 981-1250
Range on HMM: 5-272/274.0
SQLFMEFERIPKRRehALYECAlLEENEPKNHDPNFLPYDDNRVRLTP--CRDNRHGYVNASSISATvGTKQRFYIVAQSPQePLTMRIFWQCVWEADVY
 .|  ||  .|        |   .  .. ||   . || .  || |..   .|.   |.||  |    ..... |. .| |  | |.  ||. ... .| 
kdlekeflelPlnf..dqeeld.vfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPl.pntvadfWrmiyqeevq

LVVQLT---EDM-----SYIPRNSHQ--RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSrrYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAS
..| ||   |        | | . .     ..|....  |   ...  .  || | .. .   ||| .  |.|| ... |.|.|..||...| .. | ..
vivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreee

TQEVPPGhntnppvLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR
.... |        ..||  | || |. ..... .  |.... .|. ... .|| .|  .. .  ||..|.. |. ||||. 
naklapv.......vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 981-1244 2.4e-21 70.6 In-house 20-234 (392) alignment
Range on Protein: 981-1244
Range on HMM: 20-234/392.0
SQLFMEFERIPKRREhALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
. .| ||  .|         .|  | | .||   | |||| .||.|    |   . |.||| | .     .. || .|.|. . ..  ||. |.. .|  
alffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf..dnekayiasqgpn.aaslddfwrmvfqenvtt

VVQLTE----DmsyiprnshqrlefgqfqvyqefsqttdrcttiklrlyhvPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvRLastqevppG
.. .|.    |                                            .|.|   ....| ... |. .. .| |..|...           |
iamvtklkegd........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.df........G

HNTNpPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
. |  |...||  | ||.|| .. | ..    .   .|.  .. ..|..|  .. .  || |||  .. 
qyth.pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 982-1246 5.3e-36 119.1 In-house 22-279 (288) alignment
Range on Protein: 982-1246
Range on HMM: 22-279/288.0
QLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPC-RDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLV
..  |.. ...  ..   . . | .|..||  .| |||| .||.|.     .   |.||| |  .   |.. || .|.|  . |.  ||. |.| ..  .
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPl.adtvndfWelvyenktsti

VQLTED--------MSYIPRNShQRLEFGQFQVYQEFSQTTDRCTTIKLRLYhvPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRLASTQEv
| |||           | | .  .  ..|...|    |....  .. || |    .   . .  .||  |.... |.. . .|..|.    |  |.... 
vmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrq...vkvanqad.

ppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
        |.. || .| ||.|. ...| |. ...... .|.  .. .||.|| ...  | || |||. |..  
......tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 982-1243 1.1e-28 95.1 In-house 24-276 (315) alignment
Range on Protein: 982-1243
Range on HMM: 24-276/315.0
Q-LFMEFERIPKRREHALyECALLEENEPKNHDPNFLPYDDNRVRL-TPCRDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
. .  ..| ||  . | | . |   ||  ||   | ..||  ||.|     |.   ||||. |     .|.| || ||.|. . ... ||. |.| |.  
ngfkqdyesipggqlhpl.dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy..nkkrryiaaqgpn.vasvkdfwrlvfeedigk

VVQLTEDMSYIPRNSH-----QRLEFGQFQVYQEFSQTTDRCTTIKLrlYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRLASTQEVpp
.| ||. ..   |..      ... .|.. | .   .  .. |   |    |   . | |  |.|. | . . |.    ....      |.   |..|  
ivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirt...vkqhhtnsv..

ghntnPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
      ....|| .| ||.|  .| | .|  .. .. .|. ..| ..|..|  .. ...||.|||. |.
.....gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 982-1248 1.5e-24 81.3 In-house 11-279 (287) alignment
Range on Protein: 982-1248
Range on HMM: 11-279/287.0
QLFMEFERIPKRRE--HALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
..  |.... .  |   |..  |    .  ||   . ||.||.|| |.   .    |.||  ...   |..  .|.||.|  . |.| ||. |.|  .  
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasy..tddeafiaaqgPi.aatvrdfwravletrsas

VVQLTEDM--------SYIPRNsHQRLEFGQFQVYQ-EFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlaSTQ
|. .| ..         | | . .. .  | . |   ....     ..  ||| .. .|  | |  |.. .| ..  .     .. |  . .        
vitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvk.....qhi

EVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|.    .   |...|.  | ||||. |.   |.  |     .|. .|. .|| .| ... .  |....|. |.|| | 
elardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 982-1246 2e-17 58.1 In-house 7-259 (267) alignment
Range on Protein: 982-1246
Range on HMM: 7-259/267.0
QLFMEFERIPKRREH-ALYECALLEENEPKNHDPNFLPYDDNRVRLtpcRDNRHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADVYLV
..  ||| | |  .  .   . . |.|. .|.  . |||||.|| |   |.. . |.||| . .    ... .|| | | .  |.  |.. . . .|  .
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvil...rtkeeeyinasyvegy..ktknafivtqdplk.ntitdfltvihdqkvpvi

VQLTEDMS-YIP----RNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRyRSVWYLQYADWAEQNcprDVNhflDFLEELNSVrLASTQEvppg
| ||      |.     .  |  .. .. | . . .  .    | | |        . |    |  |  .    . .    .|. |  . ||  |     
vlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnint...nnk...pylkplfgi.laknql....

HNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
 | |.|....| .| ||||  |..|  |  . ... .||   . ..|.|| ... .. .| .|..||  | 
engnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 982-1246 2.4e-09 31.6 In-house 17-277 (307) alignment
Range on Protein: 982-1246
Range on HMM: 17-277/307.0
QLFMEFERIPKRREHALYECAlLEENEPKNHDPNFLPYDDNRVRLTpCRDNRHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVV
.|  ||. . |.  ...   | .. |  ||   .    | .|. ..        |. |  .  .  .| . .|.|| |.|  |.  ||  . . .|  |.
alvdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvk.fdglasdyihanylgia..ikpkkficaqgplen.tqysfwamaiqekvesvi

QLTEDM--SYIPRNSHQRLEFGQFQVYQEFSQTTDRCtTIKLRlYHVPSRRYRSVWYLQyADWAEQNcpRDVNHF--LDFLE-ELNSVRLASTQEVPPGH
 | . .  . |  . .  || || .|. | ..|      .  .    |   .  |  |.  |||...  | ..|.   .. .     . |..   .   .
mlckvielakikceqywpleegqklvfgeapntisva.nlgak.klapdedlinvttlk.vdwaqks..rtiqhlqwenwpdrgvpqinltainlleavr

NTNPPVLLHCLEGGGRSGVTLTADLLLYTL-DHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
  . ||..||  | ||||  ..  |.   . .  .  |. ... .|| ||.  | . ||| ... .|. |.
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_CG42327_pd Subfamily CG42327 982-1163 7.8e-08 26.3 In-house 6-192 (319) alignment
Range on Protein: 982-1163
Range on HMM: 6-192/319.0
QLFMEFERIPKRREHALyecALLEENEPKNHDPNFLPYDDNRVRLTPC-RDNRHGYVNASSISATVGtKQRFYIVAQSPQEPLTmRIFWQCVWEADVYLV
... ||. .|.   .|    ..    ..|..  | .|  . || |     |..  |..|| .       . .|| || . |  .   ||. |||     .
dvaeefrdlPqliarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydd.apnsyiaaqvsledss.sdfwrtvweqqsrvi

VQLTEDM--------SYIPRNS--HQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYaDWAEQNCPRDVNHFLDFLEELNS
||||.           |.| .    ..  .|...|     .. ||  .  | | .|     | . .  | .| | . | . . ..  | | .|
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

0046845 (Phosphotyrosine protein) phosphatases II 983-1249 3.8e-55 182.6 In-house 2-277 (284) alignment
Range on Protein: 983-1249
Range on HMM: 2-277/284.0
LFMEFERIPKRREHA--LYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSISATVG---TKQRFYIVAQSPQEPlTMRIFWQCVWEA
|. |||....   .    ...|||.||  ||  ...||||..||.|... .  . ..|.||| ..        ... .|..| | .  |.  ||..||| 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvweq

DVYLVVQLTEDMS--------YIPRNsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL
.| ..| ||| ..        | | . .. |..|.|.|.    .. | .|...|.| ..  .  .| |....| .| ....| .....|.||....... 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

AstqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNE---DLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
.        .....|.. ||  | ||.|. ...||||. |....    .|.. .. .|| ||   . .|.||.|.|..|. |||..
n........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

DSPc_SM00195 983-1247 3.7e-50 166.1 In-house 2-263 (263) alignment
Range on Protein: 983-1247
Range on HMM: 2-263/263.0
LFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVV
| .|||.. . ...   ..|  ..|. ||   |.||||..||.|..  . . . |.||. |. .  .|.. ||..| |. | |.. ||..||| .| ..|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPl.pstvedFWrmvweekvkiiv

QLTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQTTD-RCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqev
 |||..         | |..|..  .||...|     ....  ... .|.| .   .  |.|  .|| .| ....| . ...|..|..... .  |    
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....

ppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
      ..|.. ||  | ||.|. .|.|..|  |......||  .. .||.|| ... .|.||.|||. .. |.|
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik

PTPc_SM00194 983-1247 3.7e-50 166.1 In-house 2-263 (263) alignment
Range on Protein: 983-1247
Range on HMM: 2-263/263.0
LFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVV
| .|||.. . ...   ..|  ..|. ||   |.||||..||.|..  . . . |.||. |. .  .|.. ||..| |. | |.. ||..||| .| ..|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPl.pstvedFWrmvweekvkiiv

QLTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQTTD-RCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqev
 |||..         | |..|..  .||...|     ....  ... .|.| .   .  |.|  .|| .| ....| . ...|..|..... .  |    
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....

ppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
      ..|.. ||  | ||.|. .|.|..|  |......||  .. .||.|| ... .|.||.|||. .. |.|
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 983-1246 1.8e-23 78.2 In-house 25-288 (325) alignment
Range on Protein: 983-1246
Range on HMM: 25-288/325.0
LFMEFERIPKRREHAlYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRH-GYVNASSISATVgtKQRFYIVAQSPQePLTMRIFWQCV--WEADVYL
.  ||. .|     | .. | . ||  ||  .| ...| .|| |   .|. .  |.||| .   .  |.  .. ||.|. . |.  .|. |  |.. | .
fahefgllpsddgia.kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk..kkdvflaaqaPl.tatindlWrlvldWrcsvvv

VVQLTED-----MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastQEVPP
|.   .        | |..  .  .|| ..|     ..       .| .  |     |||  .|.  | .   ..    .. .|. .. |     . |  
vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs....ervta

GHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
  ..  |.|.|| .| ||.|| ..   .|  . ..  .||  .. .||..| |.. .  || .||. |. ..
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 984-1247 4e-25 83.4 In-house 26-279 (287) alignment
Range on Protein: 984-1247
Range on HMM: 26-279/287.0
FMEFERIPKRREHALyeCALLEENEPKNHDPNFLPYDDNRVRLTpcrDNRHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQL
|. .|.. .|...     .. ..|..||   ..|..|..|| |    .... |.||. | .    ... .|.|.||    |.| ||. ...  |  .| |
ftvleqvtqredevt..hniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgy..kekkafiiaesPmf.ntarnfWkliddrnvtaivml

TED------MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlaSTQEvppgH
...      . |    ... . .|....     .... ..  ||.. .   .   ..|   |...| ..    . .  |  .|| .      ||     .
cqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy.....ktqr....k

NTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
..| ... || .. |||.. . |.  .   . .  .|. .|. . | |.   .   .|||||......||.
rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_PTPRN_pd Subfamily PTPRN 985-1241 1.5e-26 87.8 In-house 33-287 (297) alignment
Range on Protein: 985-1241
Range on HMM: 33-287/297.0
MEFERIPK-RREHALYECALLEENEPKNHDPNFLPYDDNRVRLTP-CRDNRHGYVNASSISATvGTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQ
 |.| . . . | .  | |  |.|  ||   ..||||..||.|.    .... |.|||.|  .   ..  || .|.|  . |.  ||| |||  | ..|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildh.dprapayiatqgpl.astvadfwqmvweqGvvvivn

LTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQTTDRCtTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLastqevpp
||.           | | . ..  .. . ..  |   . |      . |  . ... |.|  . .  | |...|   . .|.|   .|            
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddyl.vrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr........

GhnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDH-NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNL
|     |...|| .| ||.|| .  ||.|  | .   ..||   .  || ||. .. . .|..|..  
G..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 986-1244 8.4e-30 99.2 In-house 3-253 (284) alignment
Range on Protein: 986-1244
Range on HMM: 3-253/284.0
EFERIPKRR-EHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQL
|| |..|.  . .  . | |..|  ||   . |..| |.|.| .   .    |.||| |.     ..  || .| |. . |.  ||. .|| ..  .| |
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy..qrkdkyiatqGPl.dntladfWrmiweyncstivll

TEDMS--YIPRNSHqrLEFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFleeLNSVRLASTQEvppghNTNP
|.|.   | | .     . ..|.|  .  . ..  .  ...| .    .  |..    .  | ..  |    ... .   .. ||  ...|     | . 
tkdkcsqywplkiv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrl...vkkvrhltske.....nhra

PVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
....||  | ||.|| .. | ||  ..... .|. ... .|| ||.... .|.||||||  |. 
nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPRK_pd Subfamily PTPRK 986-1242 2.9e-27 90.3 In-house 27-273 (314) alignment
Range on Protein: 986-1242
Range on HMM: 27-273/314.0
EFERIPKRrehalYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQL-
|.| ...      ...|  .||. ||   . |.||  ||.|..  ..    |.||. | .   .. . .||.| | .  |.. ||. |.. .   .| | 
eyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsy..krpaafivtqgPlqe.tvkdfWrlvydencasivmlt

--TEDM-----SYIPRNSHQrleFGQFQVYQEFSQTTDRCTTIKLRLYH--VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAstqevpp
  .| .      | | ....   .|...|    ...     .  .|...   .   .| |  .|.  |.. . |   . .|... .... .         
elvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.......

ghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLL
   .. ....||. |.||.|. .. | .|  ..... .|.  .. .|| ..  ..    ||||||. .
...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 987-1248 1.8e-26 87.7 In-house 26-285 (290) alignment
Range on Protein: 987-1248
Range on HMM: 26-285/290.0
FERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN---RHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQL
|... .  ..   . .| ..|...|   |...|||||. | |  ..    . |.||. |      ... ||..|.| .  |.. ||. .|. .|  .| |
fkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy..kekkqyiatqgpvs.ntlvdFWkliwqekvtiivml

TEDM--------SYIPRNSHQRleFGQFQVYQEFSQTTDRCTTIKLRLYHVPS-RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlasTQEvpp
|. .         | | .. ..  .|.|..     .|... ...||.. .  |  . .||  .|   | ..    . .  |  .|| .      ||    
tniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk.....tqr...

gHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 ...| ....|| .. |||.| ..|.  .     .   |.  |. ..| |.   . .  ||..|.....|||..
.krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPN23_pd Subfamily PTPN23 994-1248 5.3e-34 112.3 In-house 30-282 (288) alignment
Range on Protein: 994-1248
Range on HMM: 30-282/288.0
REHALYECALLEENEPKNHDPNFLPYDDNRVRLTpcrDNRHGYVNASSISATVGTKQRFyIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED-----M-
.|     .|. . .  ||   . |||| ||| |    ...  |.||| .   . .   | |..|.|... |.  ||. |.|  . ..| |..        
kearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdf.iatqaPlqs.tlnDFWlmvyeqkssviVmllskeelgkpk

--SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPghntnpPVLLH
  .| | .  .  .||...|  .  ..|. .   .|.| . .... .|| .||.  |.|   |   ...|.||.| .|   |  ...        |...|
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......Plvvh

CLEGGGRSGVTL-TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|. | ||.||       .  .  .|  |||..|. .||.||   .   .|.|| |.  ... .|
CsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_PTPN12_pd Subfamily PTPN12 998-1248 2.1e-33 110.5 In-house 31-279 (290) alignment
Range on Protein: 998-1248
Range on HMM: 31-279/290.0
LYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDM--------S
  |..  |||  ||   . |||| .|| |.  ...   .|.||..|  .  ...  || ||.|  | |.  ||. .|| .| .|| . . .         
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv..egkleyiaaqgPL.pktlddfWrmiweknveivvmaCrevelgkkkCer

YIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLrLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLastqevppghNTNPPVLLHCLE
| | . ...||||.|.| .|  ...|   .|.  |    ..  |.|  ..| .| ....|. ... |...|......           . . |...||  
YWpeegeeelefgefevtleeekavdddflirt.LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..........sedaPlvvhCsa

GGGRSGVTLTADLLLYTLDHN---EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
| || |. .. |.    | ..   |.||.  .. .||.|| ... .  ||...|. .. ....
GvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

0040439 (Phosphotyrosine protein) phosphatases II 999-1248 1.1e-48 161.4 In-house 3-248 (249) alignment
Range on Protein: 999-1248
Range on HMM: 3-248/249.0
YECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVGTKQrfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SY
|..|||.|| .||  |..|||| .||.|..... . ..|.||| |. .  ...  .|..| | .  |.  ||. .|| ..  .| ||...         |
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqy

IPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqevppghNTNPPVLLHCLEG
 |    . ||.|.|.|     .. | .|. .|.|...     | |. .|| || ....| .....|||.|...... .         ... ||| ||  |
wpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvlVHCsaG

GGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 ||.|. ..|.|.|. |... ..|.. .. .||.||  ..... ||.|.|..|. .|..
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk

0042113 (Phosphotyrosine protein) phosphatases II 999-1247 8e-47 155.1 In-house 1-244 (245) alignment
Range on Protein: 999-1247
Range on HMM: 1-244/245.0
YECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SY
|..|||.|| .||  ...||||..||.|.|   .  ..|.||| .  ..    . .|..| |..  |   ||. .|| ..  .| |||..         |
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqy

IPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAstqevppghNTNPPVLLHCLEG
 |   .. |..|.|.|.    .. | .|. .|.. ....  .| |. ..| .| ....| .....|||||...... .         . | ||| ||  |
wpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpvlVHCsaG

GGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
 ||.|. ..|.|.|. |... ..... .. .|| ||  ..... ||.|.| .|. .||
vgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 999-1247 1.7e-17 58.1 In-house 32-294 (301) alignment
Range on Protein: 999-1247
Range on HMM: 32-294/301.0
YECALLEENEPKNHDPNFLPYDDNRVRLTPCRD---NRHGYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED--------M
 .  | |||.. |.  |  .|||||. |.| ..    .. |.||| |...   ... .|.||.| .  |.. ||. .|.  .  .| .|.          
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkk.tlvdfWrliwqekpvsivmvtnlkegtkskce

SYIPRNSHQRLEFGQFQVYQEFSQT----TDRCT----------TIKLRLYHVPSR-RYRSVWYLQYADWAEQNCPRDVNHFLDFLEELnsvrLASTQEV
 | |. .... |||.|.|    .|.    . |            .   | ..| |.   ..|  || .|| ..   |. .  |  ...     .  .| .
qywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddv....ihrqqki

PPGhntnpPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
  |     ||. || .. .||||  . .. |     .   |.  |.  .|...   .  | || .||. . .||.
ggg.....pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

0037934 (Phosphotyrosine protein) phosphatases II 1000-1246 1.6e-42 141.1 In-house 3-242 (243) alignment
Range on Protein: 1000-1246
Range on HMM: 3-242/243.0
ECALLEENEPKNHDPNFLPYDDNRVRLtpcrDNrHGYVNASSISATvgtkqRFYIVAQSPQEPlTMRI----FWQCVWEADVYLVVQLTEDM--------
 .|||.|| .||. ...||||..||.|    .. ..|.||. |  |     . .|. | | .  |       ||. .|| ..  .| |||..        
siallpenlsknrysdilpydhsrvkl....eg.sdyinanliyvt.....prliatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgrekca

SYIPrNSHqrlEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNtnPPVLLHC
 | | ...   ..|.|.|    ....| .|  .|.|.... .  .| |. ..|  | ....| .....||||.|....  . .. .   ..   |||.||
qywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHC

LEGGGRSGVTLTADLLLYTLdhneDLDIPRVIGQLRHQRDS-IIPSLAQYKFIYNLLITYL
  | ||.|. ..|.|.|. |    ..|.  .. .|| ||   ..... ||.|.| .|. .|
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_CG7180_pd Subfamily CG7180 1000-1245 4.6e-34 112.4 In-house 35-289 (296) alignment
Range on Protein: 1000-1245
Range on HMM: 35-289/296.0
ECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM-------SYIP
 ..| .||  ||.|.. .||| ||| |.    . .  |.||. . .   .|.. ||| . |..  |.  ||. |.. ..  || ||. .       ||.|
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsf..lkkkeyivteapkke.tvdefWrlvydeeisavvvLtktfdfakmypsywp

RNShqRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV----------PSRRYRSVWYLQYADWAE-QNCPRDVNHFLDFLEELNSVRLAStqevpPGHNTNP
 .|  . ..|.. |    ...    .. ...|..            .   | |  .|.  |   ...|   | ......  ...|        . .... 
nks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.....dedpeeg

PVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
||. .. .|..|||| |..|  |  ....| .|. . . .||..|  .. .  .||.||..|  .
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_PTPN1_pd Subfamily PTPN1 1000-1244 1.9e-25 84.2 In-house 25-269 (290) alignment
Range on Protein: 1000-1244
Range on HMM: 25-269/290.0
ECALLEENEPKNHDPNFLPYDDNRVRLTPCrDNrhGYVNASSISatVGTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTED--------MSYIP
. | |.|| ..|   .  |||  |..|    ||   |.||| .   .   .| ||..| |  | |.  ||| ||| .   || | .         ..| |
reaklpenrnlnryrdvspydhsriklera.dn..dyinaslve..leeakrsyiltqGPl.pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

RNSH-QRLEFG--QFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRLASTQEvppgHNTNpPVLLHCLE
.. . . |..   ...|     ....  |  .|.|  . ... |..    |  |..   |.  . ||.|| .   || . .      ..   |...||  
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfk...vresGsls....sdvG.pavihcsa

GGGRSGVTLTADLLLYTLDHNED---LDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
| ||||    .| .|  .....|   .|| .|. .||..|  .|    | .| |  .. 
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1000-1242 4.2e-24 79.9 In-house 26-262 (283) alignment
Range on Protein: 1000-1242
Range on HMM: 26-262/283.0
ECALLEENEPKNHDPNFLPYDDNRVRLTPCRDnrhGYVNASSISATVG-TKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDMS--------YI
..|  .||..||.  . .|.| .||.| .       |.||. |  .    ... ||.|||| .  |.. ||. |.. ..  .| ||. .         | 
diasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldr.tvvdfWkmvfdekitaivmltklqedlrikCsqyW

PRNShqRLEFGQFQVYQEfSQTTDRCTTIKLRLYHVP--SRRYRSVWYLQYADWAEQNCPRDVNHFLDFleelNSVRlaSTQEvppgHNTNPPVLLHCLE
|..     ..|.| |  .  .|| .  .||. | .|   ..    . . |. || | .    .| .. |    | |.  | |     .. . |...|| .
PkrG..sedyGeftvtlr.kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf....nkvi..slqt....eskkgPivvhCst

GGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLL
|.||..| ..|   .  .  .  .|.. |.  .| ||  .. .| |||....| 
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1001-1251 3.9e-29 96.5 In-house 38-283 (315) alignment
Range on Protein: 1001-1251
Range on HMM: 38-283/315.0
CALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTE----DM----SYIP
 |  ..| .||   | ||.| .||.|    |.  . |.||| | .    ... || .| |. . ..  ||. |.. .|  .| .|.    |      | |
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksv..dddkayiasqgPl.kasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

RNSHQRLEFGQFQVYQeFSQTTDrCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlaSTqevppGHNtNPPVLLHCLEGGG
 .  .  |||...|   .|  .|   ... .|    |  .| |   |. .| ..  ....  .| .. |. .    .      |.. . ..|.||. | |
drkadsvefGsikvel.lslead.tdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevka....dn.....gkk.efsllvhcsaGvG

RSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK-RTRL
|.|| ...|  .  . ... .|. ... .|| .|  .. .  .| |||. .  .|. |  |
rtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntl

0049772 (Phosphotyrosine protein) phosphatases II 1001-1248 3e-22 75.2 In-house 40-282 (314) alignment
Range on Protein: 1001-1248
Range on HMM: 40-282/314.0
CALLEENEPKNHDPNFLPYDdNRVRLTPCRDNRHGYVNASSISATvgtkqRFYIVAQSPqEPLTMRIF----------WQCV--WEADVYLVVQ------
 | |..|  ||  ...||.| |||.|     . ..| ||| ..       . .|..| |  . |.  |          |. |  .. .|  .|       
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTEDMSYIprNSHQRLEFGQFQvyqefsqttdrcttiklRLYHVPSRRYRSVWYLQYADWAEQNCPrDVNHFLDFLEELNSVrla
               |.. . .   |     .. ...                 . .. |..  | .  . . ..   ..| . ..|..||| ....   
adelsrLdaAlgKtpllildgng..neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea...

StqevppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLdhneDLDIPRVIGQLRHQRD-----SIIPSLAQYKFIYNLLITYLKR
.         .. ||| ||  | ||.|. ..|..|.. |    ....  .. ..| .|      . |..| || ||.. |  |||.
d.........kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1004-1251 9.3e-28 91.6 In-house 40-282 (515) alignment
Range on Protein: 1004-1251
Range on HMM: 40-282/515.0
LEENEPKNHDPNFLPYDDNRVRLTPCRDNRH-GYVNASSISATVGtkQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTE----DMS----YIPRNS
 | | .||   | |||| .||.|    || |  |.||| | .     .. || .| |..  ..  ||. |.. .|  .. .|.    | .    | |   
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn..dkayiasqgPnk.asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

HQRLEFGQFQVYQeFSQTTdRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlaSTqevppGHnTNPPVLLHCLEGGGRSG
 . ..||...|    |  .    .|| .|  . .  .| |   .. .| ..  |.. . .| .. |. .    ..     |.  . |...||. | || |
gdsvkfGsikvel.vslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka....dh.....gq.ythpliihcsaGvGrtG

VTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK-RTRL
| ...|  .      . .|. ... ..| .|  ..    || |||. .  .|. |  |
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1005-1244 5.4e-23 76.1 In-house 46-277 (439) alignment
Range on Protein: 1005-1244
Range on HMM: 46-277/439.0
EENEPKNHDPNFLPYDDNRVRL--TPCRDNRHgYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLT---EDMSYIPrnSHQRLE
| ...||.  .  ..|  || |  .|     | |.||  |      ....|| .| |..  |   ||. |.|  .  .|.||   | . | |  | .   
eydqtknrykdvgafdhtrvtlqeipgvphsh.yinanyikGyy..ddklyiatqgpkke.ttddfwrlviekktvtivmltnlvesykywp..sdaevc

FGQFQVYQEFSQTTDRCTTIKLRLYH--VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlaSTQEVppghntnPPVLLHCLEGGGRSGVTL
.|.  |  .      . .   ....     ... |.|  ..|  | ..| | .  | ||||  .||     ..|.        ||..||  | ||.|  .
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan..dkeey.......gpvvvhcsagvGrtGtii

TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
. |. |  |  .. .||  ..  ||.||  .. .|.|| |||| .. 
aldialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1006-1247 1.6e-28 94.6 In-house 8-243 (250) alignment
Range on Protein: 1006-1247
Range on HMM: 8-243/250.0
ENEPKNHDPNFLPYDDNRVRLTPCR-DNRHGYVNASSISATVGTkqRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED-------MSYIPRNSHQr
.|. || . .....|  || | . . |.   |.||| . .  ..  . .|..|.| .. |.  ||. |.| ..  .| ||.          |.| .  . 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqa.tiedfWrmvleeksgtivmLtnLkesektyhqywPvekae.

lEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlASTQEVppghnTNPPVLLHCLEGGGRSGVTL
 ..|. .|    ...    |. || | .      | |  |..  | ..  |.  .  |..|....    || |..      | ||...| .| ||||  .
.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq....asqqqa.....gnaPvivqCsaGvgrsGafi

TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
. | .|  | ... .|. .|| .||..|   . ||.|| |.|.... .|.
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1006-1248 1.1e-27 91.7 In-house 19-266 (270) alignment
Range on Protein: 1006-1248
Range on HMM: 19-266/270.0
ENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVGTKQRfYIVAQSPQePLTMRIFWQCVWEADVYLVVQ---LTED-----MSYIPRNSHQ
 ..  |   . ||    |||| . .. ..  |.||  .    | |.. || |..|. | |.. ||. .||  |  .|    |.|.       | | ....
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPl.pttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--RLEFGQFQVYQEFSQTTDRCTTIKLRLYhVPSRRYRSVwYLQYADWAEQNCPRDVN---HFLDFLEELNSVRLASTQevppgHNTNPPVLLHCLEGGG
  .||.|. .| .. .. ..   . .|||    . . | |   .| .| ..  ||. .   .  . |. |. ||  ...     .. . |.| || .| |
kvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrseke.....ldkaePllvHcsaGvg

RSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|.|. .. |  . .|.... .|. ..| .||..|  ..    ||.|.|. ...| .|
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1006-1241 6.3e-17 56.6 In-house 2-234 (237) alignment
Range on Protein: 1006-1241
Range on HMM: 2-234/237.0
ENEPKNHDPNFLPYDDNRVRLTPCRDNrHGYVNASSISATVGTKQRfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SYIPrNSHQR
||. ||.  |   || .|| |  .  .   |.||. .    || .. || || | |. .   ||| ||.    ..| ||  .         | | ...| 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkk.yiaaqgples.scddfwqmvwqekcsvivmltgliegnelkchkywp.stdqp

LEFGQFQVY----QEFSQTTDRCTTIKLRLYHVpsrRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELnsvrLASTQEVPpghnTNPPVLLHCLEGGGRS
  .|.. |     .|||. | |. ..  ||        | ..  |.. | ..  |.    .| |  ..    .  .. |.       | ..||  | ||.
aaygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkni....inrsphvs....esgpwiihcsagvgrt

GVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNL
|. |  | .|     .. .||   .  .  .|  || .  || ||.. 
giflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1006-1239 7.8e-10 33.3 In-house 7-234 (239) alignment
Range on Protein: 1006-1239
Range on HMM: 7-234/239.0
ENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATVGTKqRFYIVAQSPQEPLTmRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLEFGQfQ
 |. ||.  | . || .|| |    ..    |.||| .    |.  . || .|   |. .   ||. .|.    ..| ||  .    .. ||        
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveiss.gdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

VYQEFSQT---TDRCTTIKLR---LYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLdfleelnSVRLASTQEVPPGHNtnpPVLLHCLEGGGRSGVTLT
 | ..  |   |.  .   .|   . .|     | |.  ... | ..  |.     |        .|   |..  ||     | ..||  | ||.|  | 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl.......glrrkitkdslpgar...pwvihcsagvgrtgaflv

ADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIY
 | .|    ... .||   .  .| .|  .. .  || ||.
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

Y_phosphatase Protein-tyrosine phosphatase 1007-1243 7.5e-51 168.2 Pfam-A 1-234 (235) alignment
Range on Protein: 1007-1243
Range on HMM: 1-234/235.0
NEPKNHDPNFLPYDDNRVRLTPCRDNRHgYVNASSISATVgTkQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSHQRL
|. ||  ...||||..||.|.   ..   |.||. .. .  . .. .|..| | .  |.  ||..||. .| ..|.||...         | |..... |
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.e.kkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGQFQVYQE--FSQTTDRCTTIKLRLYHVPSR-RYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastqevppgHNTNPPVLLHCLEGGGRSGV
..|...|  .   .. ....|. ||.| .  .. . |.|. |.| .| ....|......||....... .          .... ||. || .| ||.|.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtgt

TLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
 ...|.||  |...|..|.  .. .||.|| ... ||.||.|.|....
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1007-1243 7.5e-51 168.2 In-house 1-234 (235) alignment
Range on Protein: 1007-1243
Range on HMM: 1-234/235.0
NEPKNHDPNFLPYDDNRVRLTPCRDNRHgYVNASSISATVgTkQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSHQRL
|. ||  ...||||..||.|.   ..   |.||. .. .  . .. .|..| | .  |.  ||..||. .| ..|.||...         | |..... |
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.e.kkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGQFQVYQE--FSQTTDRCTTIKLRLYHVPSR-RYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastqevppgHNTNPPVLLHCLEGGGRSGV
..|...|  .   .. ....|. ||.| .  .. . |.|. |.| .| ....|......||....... .          .... ||. || .| ||.|.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtgt

TLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
 ...|.||  |...|..|.  .. .||.|| ... ||.||.|.|....
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1007-1246 4.6e-27 89.9 In-house 51-284 (297) alignment
Range on Protein: 1007-1246
Range on HMM: 51-284/297.0
NEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgtKQRfYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDM-------SYIPRNSHQRl
| .|.   | |||| .||.|    |.    ||||| . .    |.| .|  | |. . |.  ||. |.. .|  .| |..|         | . .. .  
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgn...khr.littqmPm.katvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt.

eFGQFQVYQEfsQTTDRCTTIK--LRLYHVPSRRYRSVWYLQYADWAEQNCPR--DVNHFLDFLEELNSVRlastqevpPGHNTNpPVLLHCLEGGGRSG
 ||.  |  .   ...|.  ||  | . .  ..  | |   |. .| ... .|  ... .|....|.. .          ... . |.|.||| | || |
.fGdvsvvll..svsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdf........sqnaeg.PllvhclaGvGrtg

VTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
| || |  .    .....||  .. .||..|  ..    ||||.|.... .|
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

0041856 (Phosphotyrosine protein) phosphatases II 1007-1246 2.3e-22 74.9 In-house 1-171 (182) alignment
Range on Protein: 1007-1246
Range on HMM: 1-171/182.0
NEPKNHDPNFLPYDDNRvrltpcrdnRHGYVNASSISATVGTKQrfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTeDMSYIPrnshqrlefgqfqvy
| .||  ...|||| .|            |.||. .     ...  .|..| |    |.  |.. ..| .. ..| || .  | |               
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgplls.tvadflrmlkelgittivnlt.eelywp...............

qefsqttdrcttiklrlyhvpSRRYRSVWYLQYADWAEQNCPRdVNHFLDFLEELNSvrlastqevppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTl
                     .. .| .. ..|  |   ..|  ....|||.|| ..               . ||| ||  | ||.|.   |.|...  
.....................ellerlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlVHCsaGvgRtgtlvaaylmkkl.

dhneDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
    ..... .. ..| .|  .. .. || |.. .|  .|
....gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_ptpA1_pd Subfamily ptpA1 1007-1209 2.6e-11 37.9 In-house 47-259 (418) alignment
Range on Protein: 1007-1209
Range on HMM: 47-259/418.0
NEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISatvGTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDMSY----IPRNSHQRLEFG
|  ||.  | || .  ||.|   .|.    |.||  |    |.  . .|..| |  | |.  ||. |||  . ..| |. .         |   ...   
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid...gaypkqfictqgpl.pntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

QFQVYQEFSQ--------------TTDRC-TTIKLRLYHvpSRRYRSVWYLQYADWAEQNCPRDVNHFLDFleeLNSVRLASTQEVpPGHNTNPPVLLHC
|| .| .  .                .|   | ..||        | .   ||  | ..| |   . | ..   | |.     | . |  . | |...||
qfsiygngnevfgtysvelveviqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrql...lhsitnrqnqii.pssdrnvpiivhc

LEGGGRSGVTLTADLLLYTLDHN
  | ||.|   || ...  ||| 
sagvgrtgtfctavimmkkldhy

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1007-1239 1e-09 32.9 In-house 7-233 (239) alignment
Range on Protein: 1007-1239
Range on HMM: 7-233/239.0
NEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATVGTKqRFYIVAQSPQEPLTmRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLEFGQfQV
|. ||.  | . || .|| |    ..    |.||| .    |.  . || .|   |. .   ||. .|.    ..| ||  .    .. ||         
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveiss.gdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

YQEFSQT---TDRCTTIKLR---LYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLdfleelnSVRLASTQEVPPGHNtnpPVLLHCLEGGGRSGVTLTA
| ..  |   |.  .   .|   . .|     | |.  ... | ..  |.     |        .|   |..  ||     | ..||  | ||.|  |  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl.......glrrkitkdslpgar...pwvihcsagvgrtgaflvi

DLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIY
| .|    ... .||   .  .| .|  .. .  || ||.
damlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1008-1247 7.9e-15 49.6 In-house 55-272 (288) alignment
Range on Protein: 1008-1247
Range on HMM: 55-272/288.0
EpknhdpnflpyDDNRVRLTpcrDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTE--------DMSYIPRNSHQRLE
            |  ||.|.   |. . |..|  .|..    .|  | ||.|    |. ..|. . |.||  .| |.|           | | .  ..  
c...........ditrvkls...ddpdfyiaanvvssa..kykrrlicaqaPl.ngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGQFQVYQEFSQtTDRCTTIKLRLYHV--PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELnsvrlastqevppgHNTNPPVLLHCLEGGGRSGVTL
.|..      .. .|   ..|. | ..  .      | .| . .| ..  | .   .| .|| |              .... |...|. .| ||.|   
igrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..............kslqkPivvhssaGvGrtgtli

TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
   . | .|  ...| |.... .|| .|   | .  || ... ..  .| 
lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1009-1090 2.4e-09 31.4 In-house 49-142 (350) alignment
Range on Protein: 1009-1090
Range on HMM: 49-142/350.0
PKNHDPNFLPYDDNRVRLT----PCRDNRH-----GYVNASSISAT---VGTKQRF-YIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDMSYI
 ||   | |||. .||.|     .    .|      |.||. .. |   |  .  | || .|.|  | |.  |.... . .| ... ||.|. . 
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPl.pstvddfykvillnkvkvilsltsdveln

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1010-1246 2e-23 77.7 In-house 36-295 (297) alignment
Range on Protein: 1010-1246
Range on HMM: 36-295/297.0
KNHDPNFLPYDDNRVRLTPCRDNRhGYVNASSISATVGTKQRFYIVAQSPQEpLTMRIFWQCVWEADVY---LVVQLTED-----MSYIPRNSHQRLEFG
||   . | .||.||.|     .|  |.||  .      ..  ||.|| | .  |.  ||. |.| ||    .| .| ||     . | |.   .||. |
knryrdilatddtrvkllrviter.dyinadyvvfpdeeadlkyilaqGpls.atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

QFQVyQEFSQTTDRCTT---IKLRLYHVpsRRYRSVWYLQYADWAEQNCP---RDVNHF--------------LDFLEELNSVRLASTQEVPPGHNTNPP
.. | .  |.|.|   .    .|.|..    . | | . |.  | .   |    |.. |              |  .| . .. .   . .   .  | .
dvvv.eflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnay

VLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
.|.||  | ||||| . .| .|  | ..   |.  .. .||.||  .. .| |....|.. .  |
llvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1010-1251 2e-07 25.0 In-house 51-292 (305) alignment
Range on Protein: 1010-1251
Range on HMM: 51-292/305.0
KNHDPNFLPYDDNRVRLTPCrdNRHGYVNASSISATvgTKQRFYIVAQSPQEPLTMRIFWQCVWEA--DVYLVVQLTED-----MSYIPRNSHQRLEFGQ
||   .    |.|||.| .     | |. |  .|.   |. . .| .|.| |     ... |. .    .... .| |      . |.. . .. ||| .
knrykdvgcldnnrvklegp..wpheyihanyvstp..tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

----FQVYQEFSQ------TTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRlastqevppghNTNPPVLLHCLEGGGR
     .|  | |.       ..   |    .   |  . | |    . || ..  |   .  |..||.    |            .  |. .||  | ||
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek...ar...........pskgpivvhcsagigr

SGVTLTADLLLYTLDHNEDL-DIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTRL
.|  .  . .|  |   . . |  ... ..| ||.  | . ||| |...... |... .|
tgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl

subfamily_eak_pd Subfamily eak 1016-1248 1.9e-19 64.2 In-house 60-307 (332) alignment
Range on Protein: 1016-1248
Range on HMM: 60-307/332.0
FLPYDDNRVRLTPCRDNRHGYVNASSIS-ATVGTKqrfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVY
 .||| . ||||... || ||.||| .  . || |   ||..  ..|   . .||| | |     .||| ||.         | | .... |.||...| 
ivpydrylvrltssqlnrlGyinaslaefsevGrk...yiltGiased.kvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

Q-EFsqtTDRcTTIKLRLYHVPS-RRYRSVWYLQYADWAEQNCPRdVNHFLDF---LEELNSVRLASTQEV------PPGHNTNPP--VLLHCLEGGGRS
. ||     |   .. ||. .        | . ..  |.| . |. .. || .   . |   . |. ...          . | |    .. .  |. |.
rkef...vkr.niletrllelskGnethrvlhykvfGwtettlpk.yedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsara

GVTLTADLLLYTLDHN--EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|| .  |||.  .| .  .   .  .| . ...|   ..   |. |||.... ||.|
Gvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr

0044763 (Phosphotyrosine protein) phosphatases II 1018-1246 7e-18 60.3 In-house 1-171 (178) alignment
Range on Protein: 1018-1246
Range on HMM: 1-171/178.0
PYDDNRVRLTPCRD-NRHGYVNASSISatvgtkQRFYIVAQSPqepltmRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHqrlefgqfqvyqe
|.|..|| |.. .. .|  | ||| |        ..|. .. |        ... ..| .. ..| |||..         | |.. .             
pldrtrvllsnleglersdyinaseil......pglylgslpp......addlellkelgithivnlteelelgflkcdpywpeeag.............

fsqttdrcttiklrlyhvpsrryrsvWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTldh
                          .  ..  .   ..|    |||.|.| .....          .. . ||| ||  | ||||.   |.|...    
..........................iqylhipipDhgvpdllehflefvefieeal..........dekggpvlVHCsaGvgRsgtlvaaylmkkl...

neDLDIPRVIGQLRHQRDsIIPSLAQYKFIYNLLITYL
  .|... .| ..| .|  |.|.  |....| .   .|
..glsleeaielvrerRp.ivpnpgqlrqLyefelrll

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1018-1247 1.6e-07 25.3 In-house 67-284 (290) alignment
Range on Protein: 1018-1247
Range on HMM: 67-284/290.0
PYDDNRVRLTPCRDNrhGYVNASSISatvGTKQRfYIVAQSPQEPLTMRiFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEF
  |  || |    |    || |  .    |.|   .|..| . .  ..  .|. | . .|  .| | | .         | | .. . | ||.. |    
cndktrvilkdGydG..dyvhanyvk...Glkam.filtqGalkdtvid.iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcse

SQTTDRCTTIK-LRLYHVPSRRYRSVWYLQYADWAEQNCPrdvNHFLDFLEELNSVRLASTqevppghntnpPVLLHCLEGGGRSGVTLTADLLLYTLDH
... |  .  | | . .. | .   . .|.   | ..  .   .  | .|  | ..| ||            || .||  | ||.|   . .  |  | .
eddkdaniikktlsvrdkdsGkehklkhlkikswpdksva...lstlallrtlrilrkasG...........pvvvhcsaGiGrtGtfvaievglqilld

NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
  .||.  ..  ||. | . .    ||  . ..|. . |
GkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1020-1246 9.2e-08 26.1 In-house 68-289 (305) alignment
Range on Protein: 1020-1246
Range on HMM: 68-289/305.0
DDNRVRLTPCRdnRHGYVNASSISATVGTKQRFyIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQ
| . |.|         |. |  . . .  ..|| |.|| | .  |.  ||  | .  |  .| |   .         | |    ..||.    | .. | 
dqsavkldkps..psdyihanyvgcpmipekrf.icaqgpldq.tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsg

--TTDRCTTIKLRLYHVPS--RRYRSVWYLQYADWAEQNCPRdvnHFLDFLEELNSVRlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD
    .| . |.. | ..     .  || .||...| ..  |      |  || | ..|            .. |...||  | ||.|  .. . .|  . 
skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvpp...ckltslellsair...........gskvpivvhcsagigrtgtivaieyilekia

HNEDL-DIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
 | .   .| ..  || ||   | .  || ||. ... |.
enkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

0043147 (Phosphotyrosine protein) phosphatases II 1031-1239 1.5e-22 75.6 In-house 2-154 (172) alignment
Range on Protein: 1031-1239
Range on HMM: 2-154/172.0
DNRHGYVNASSISATVGTKQrfYIVAQSPqEPLTMRIFWQCVWEADVYLVVQLTEDmsyiprnshqrlefgqfqvyqefsqttdrcttiklrlYHVPSRR
|... |.||| .. .. ...  .|. | |  . |.  ||. ..| .. ..| |||                                      .. |.  
degsdyinasyldlyyipdr..fiatqgp.lrntladfwrmlkelgithivnltel.....................................lydpell

YRSVWYLQYADWAEQNCPrDVNHFLDFLEELNS--VRLAstqevppghntNPPVLLHCLEGGGRSGVTLTADLLLytldhnEDLDIPRVIGQLRHQRDSI
.|... ..|  |  ...| . ...|.||| ...  ..             . ||| ||  | ||.|.   |.|.|      ..|..  .. ..|..|  .
erlgiqylylpwpDhgvp.llellleflefidellalsp...........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

IPSLAQYKFIY
...  ||.|.|
vqnpsqyrfly

0051429 (Phosphotyrosine protein) phosphatases II 1034-1247 1.1e-23 79.7 In-house 4-226 (272) alignment
Range on Protein: 1034-1247
Range on HMM: 4-226/272.0
HGYVNASSISATVG-TKQRFYIVAQSPQEPlTMRIFWQCvWEADVYLVVQLTEDM-------SYIP-----------RNSHQRLEFGQFQVYQEFSQTTD
 ||.||. ..   . .| .... .. | .  | . ||.  .| ..  .| |....       .. .            .|... ..|.. |.  . ....
sgyiNardvggygrvvkpgrlyrsggplpl.taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

RCTTIKLRLYHV-PSRRYRSVWYLQYADWAEQNCPRDVnhFLDFLEELNSvrlastqevppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLD
 ..  .|.|... .   .| |. |.| ||   . |..   .|..||.|..               . ||| ||  | .|.|.   ..|||. ....  .|
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------IPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
        . ... .|| ||  .... .||.|.|. |. .|.
dYlltnlyleeaveelraqrpgavqteeqylflyeallellr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1034-1245 2.3e-06 22.0 In-house 46-258 (290) alignment
Range on Protein: 1034-1245
Range on HMM: 46-258/290.0
HGYVNASSISATVGTKqrfYIVAQSPQEPL------TMRIFWQCVWEADVYLVVQLTEDM------------SYIPRNSHQRLEFGQFQVYQEFSQTTDR
 .|. |. ..   | .    |. |||||        |.  ||  . .  |  ||.| | .             |.| .  . | |. ..|      . | 
ddyiHAnrvtcpnglr...liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

CTTIKLRLYHVPSRRYrSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlaS-TqevppghntnpPVLLHCLEGGGRSGVTLTADLLLYTLD-HNEDLD
  | .| . .   . .  |   .. .| . | ..|   .|. .. ..     | |           ||..|| .|  || .  . .|    .   .... 
vetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvka....skt...........pvivHcvdGiSrsAalaaiilgyQkiaetsgsvk

IPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
.  |. .||.||.  | |  .. |.   .. .
ledvlkalrkqralaitsalelafvdagivll

0036282 (Phosphotyrosine protein) phosphatases II 1035-1240 1.8e-22 75.3 In-house 3-164 (174) alignment
Range on Protein: 1035-1240
Range on HMM: 3-164/174.0
GYVNASSISATVGTKqrFYIVAQSPQEpltmriFWQCVWEADVYLVVQLTEDMSY--------IPRnshqrlefgqfqvyqefsqttdrcttiklrlyhV
 | ||| .. .. |.   .|. | | .      ||. ..| ..  ||.|.| .           |.                                  
dyinaspldlsyitp..rliagqgpla......fwemlkelgittvvmlleekelglykcinywpe.................................l

PSRRYRSVWYLQYADWAEQNCPRDVNhFLDFLEELNSVRLAstqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDhNEDLDIPRVIGQLRHQRD
..  .|... ..|  |   ..| .   .|.|.........          . . ||| ||  | ||.|.   |.|.|. |  .   |. ... .|| || 
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

SIIPSLAQYKFIYN
 ....  ||.|.| 
gmvqtpsQyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 1035-1240 9.5e-17 56.5 In-house 4-147 (151) alignment
Range on Protein: 1035-1240
Range on HMM: 4-147/151.0
GYVNASSISATvgtkqrfYIVAQSPqepltMRIFWQCVWEADVYLVVQLTEDM------SYIPRNShqrlefgqfqvyqefsqttdrcttiklrlyhvps
.| |.| .          ... . |     .  |.. ..| ... .| |....      .| |...                                  
dyinfsyvtgg.......lyrsggp.....ladflellkelgiktivnlrseeergycpeylpelg..................................

rryRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTldhnedLDIPRVIGQLRHQRDSI
   . |..... || ....|   . .|.|||.|..             . | ||| ||  | ||.|.   ..|.|.       ...  .. ..| .|  .
...ievlhipildwpdpglplsfdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgv

IPSLAQYKFIYN
. .  |. |.. 
vqpnqqflfqlf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1044-1234 3.5e-08 27.5 In-house 84-269 (301) alignment
Range on Protein: 1044-1234
Range on HMM: 84-269/301.0
ATVGTKQRFyIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSR---RYR
 | |  .|| |..|.| .  |.  ||  .   ||  .| |.. .        .|.| . ...|. |.|..  . ...  .  ..| .|  . |      |
ptsGhphrf.iatqgPlk.ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatr

SVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSL
.| . ||..|.... |.   .  |..| .               ... |...|| .| |||   .... |   .. .  ... . . .||..| . .   
tvthyqysewtdrgvPkshaelfdlmelvk..............ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn

AQ
 |
sq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1049-1240 6.7e-12 40.0 In-house 3-198 (199) alignment
Range on Protein: 1049-1240
Range on HMM: 3-198/199.0
KQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLY--HVPSRRYRSVWYLQ
 || ||..| |    ||  ||| |||.    .| . .|          | |       ..| . |  .   |    |   | |          | . . |
gqrryiatqhplr.etmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YADWAEQNCPrDVNHFLDFLEELNSVRLASTQEvppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN--EDLDIPRVIGQLRHQRDSIIPSLAQYK
.. | |.  | .|  |. |.     |     ||       . ||..|| .| | .|| .. |. . . .      .|.  |  .||  |  || || .|.
ftswkekttp.nvalfvgfvvasrevskkyeqe......kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

FIYN
|||.
fiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1050-1240 1.1e-11 39.2 In-house 3-197 (198) alignment
Range on Protein: 1050-1240
Range on HMM: 3-197/198.0
QRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLY--HVPSRRYRSVWYLQY
|| ||..| |    |.  ||| |||.    .| . .|          | |       ..| . |  .   |    |   | |          | . . |.
qrryiatqhplr.etladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

ADWAEQNCPrDVNHFLDFLEELNSVRLASTQEvppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN--EDLDIPRVIGQLRHQRDSIIPSLAQYKF
. | |.  | .|  |. |.     |     ||       . ||..|| .| | .|| .. |. . . .      .|.  |  .||  |  || || .|.|
tswkekttp.nvalfvgfvvasrevskkyeqe......kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

IYN
||.
iyq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1050-1243 2.8e-09 30.8 In-house 235-435 (440) alignment
Range on Protein: 1050-1243
Range on HMM: 235-435/440.0
QRFYIVAQSPQEPlTMRIFWQCVWEADVYLV---VQLTEDMS--YIPRNSHqRLEFGQFQVYQEFSQTTDRCTTIKLRL-YHVPSRRYRSVWYLQYADW-
.  .| .| | .  |.  ||. | .  .  .    || .     | | |.   . || | | .  |.  .|     | | |.      |      .  | 
knafiatqmplds.tvldfwrlvhdyristiimlnqlndktcsiywpvntr.svtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwi

------AEQNCPRDVNHFLDFLEELNSVRlaSTQEVPPGHntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYK
      ....|   |  ..|.|.  .  |  ||..  ||    ||.|.||| |   |||  |    |  |. .  .|. . .  ||  |  ..|.|..| 
qsdgvqsqeqcmdavlqlmdylrkceiqr..steqsrpgd..gppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyl

FIYNLLI
. |.|| 
lcykllt

0046846 (Phosphotyrosine protein) phosphatases II 1052-1247 1.4e-18 62.8 In-house 24-174 (176) alignment
Range on Protein: 1052-1247
Range on HMM: 24-174/176.0
FYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED--------MSYIPRnsHQR--LefgqfqvyqefsqttdrcttiklrlyhvpsrryrsvwYLQYAD
..|. | | .  |.  |.. ..|.....|| |||.        . | |.   ..  .                                       .. .
rpiatqgplpr.tladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................................qylhlp

WAEQNCPRDvNHFLDFLEELNSVRlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYtldhNEDLDIPRVIGQLRHQRD-SIIPSLAQYKFIYN
| . ..| . ...|..||......           . . ||| ||  | ||.|. . |.|| .    . .|..  .. ..| ||   .... .||.|.| 
wpDhgvpdl.elllellefireal...........keggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflye

LLITYLK
 .  .||
fellllk

0049260 (Phosphotyrosine protein) phosphatases II 1061-1240 1.8e-15 52.4 In-house 18-144 (152) alignment
Range on Protein: 1061-1240
Range on HMM: 18-144/152.0
EPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLefgqfqvyqefsqttdrcttiklrlyhvpsrryrsvwYLQYADWAEQNCPRDVNHFLDFLEE
 | |.  ||. ..| ..  .| |||..       .|                                         ..  |   ..| .  ..|..|. 
gpntladfwrmlkelgittivmltellelgklkceqyi.....................................qylhlpwpDhgvpdlsqlllflllf

LNSVRLASTQevppghntnpPVLLHCLEGGGRSGVTLTADLLLytldhnEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYN
..  .| .            ||| ||  | ||.|.   |.|.|       ....  .. ..| .|  ..|.  |..|.|.
ieklaldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1062-1245 7.2e-07 23.5 In-house 38-220 (255) alignment
Range on Protein: 1062-1245
Range on HMM: 38-220/255.0
PLTMRIFWQCVWEADVYLVVQLTED--------MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNH
 ||.  |.| .  ..   || |..          ||.| .  ..| . . .|    | .     |... ..    .. . | . .|  | |.| |.. . 
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FLDFLeelnsvRLAStqevppghNTnPPVLLHCLEGGGRSGVTLTADLLLY----TLDHNE--DLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
 |  |      ...         ..  .|..|| .|.|||     |.|.      .||  |  .||  ... .||..| . |.   |  |   .....
ilnil......kvvr........ds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

0048076 (Phosphotyrosine protein) phosphatases II 1095-1243 1.5e-17 59.0 In-house 8-140 (145) alignment
Range on Protein: 1095-1243
Range on HMM: 8-140/145.0
HQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAstqevppghntNPPVLLHCLEGGGRSG
 ..| .| . . ... .  |   |  |.| . ..  .| .. ..| .|   ..| . ...|.||| ..... .           . ||| ||  | ||.|
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtg

VTLTADLLLYtldhnEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
.   |.|.|.     ...... .. ..| ||  ..|.  |..|.| .. 
tlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 1118-1240 1.3e-14 49.7 In-house 33-139 (144) alignment
Range on Protein: 1118-1240
Range on HMM: 33-139/144.0
TIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVrlastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLytldhNEDLDIPRV
 | |.  . |    | .. ... .|   ..| . ...|.||| ....           .. . ||| ||  | ||.|.  .|.|..      ..|..  .
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea...........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleea

IGQLRHQRDSIIPSLAQYKFIYN
. ..| .|  ..|.  |..|...
lalvrsrrpgavpnpgqlrfLle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1133-1247 8.9e-07 22.5 In-house 219-345 (349) alignment
Range on Protein: 1133-1247
Range on HMM: 219-345/349.0
SVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLY----TLDHNEDLDIP--------RVIGQ
 .. ||. .| .     .   .|  ||  | .      .     .  ...|.||  | ||.||  | ||||     . ..   ....         .. .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRHQRDSIIPSLAQYKFIYNLLITYLK
|| || |..  |||. .||. |. |..
lrkqrismvqnlaqfiaiyealLkyfa

PTPc_DSPc_SM00012 1134-1242 1e-21 72.5 In-house 2-103 (105) alignment
Range on Protein: 1134-1242
Range on HMM: 2-103/105.0
VWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQevppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN-EDLDIPRVIGQLRHQRDSIIPSL
|  ..| .| ....|......|..|....... .|..        ..||..||  | ||.|.  ..|.||  |... . .|| ... .||.|| . . ..
vkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

AQYKFIYNLL
.|| |.|. |
eqylflyral

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1134-1246 2e-07 25.0 In-house 217-344 (350) alignment
Range on Protein: 1134-1246
Range on HMM: 217-344/350.0
VWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLY-------TLDHNEDLD--------IPRVI
|. ||.  | . .   . . .|  ||  | .    . |     .  .|.| ||  | || |. .| | ||        . .. . ||        |  ..
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

GQLRHQRDSIIPSLAQYKFIYNLLITYL
 .||.|| |.. .| |. |||. |  | 
nelrkqrismvqnldqfifiYeallfyf

subfamily_CG42327_pd Subfamily CG42327 1178-1247 4.7e-12 40.2 In-house 246-316 (319) alignment
Range on Protein: 1178-1247
Range on HMM: 246-316/319.0
TNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN-EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
 . |. .|| .| ||.|. ...|. . .|... . .|||... ..|..| | . .  ||.|||. |  | |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak