Gene mop in Drosophila melanogaster

Synonym: CG9311, Dmel\CG9311, sfv, Dmel_CG9311, mop

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP042_AA protein Get Run
DmelP042_AA_1512-1787 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
BRO1 BRO1-like domain 8-388 3.2e-103 333.6 Pfam-A 1-375 (377) alignment 
Range on Protein: 8-388
Range on HMM: 1-375/377.0
HMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHT---TKDGAPVMKRYYCQLHALQNRFPqlaDRGI-FTFKWKDLY-HSAVH
....  || . |     .|..|| | |.|....|......|..||..|...   ...|  ...||| ||..|..|||   || .  .|.|.| . ..  .
plislplKetkevdlskpLsdyIletygeesssyeddlaelnklRqaavtpssrdesglelllrYyaqLellekrfp...drslkveFtWydafdtgspl

EVTDLRFERAAVLFNIAALHTQSGASVTRGDVDGMKMACTHFQAAAWAYGELRERYANVNGGgDfMTPELLVFQQQVCFAQAQECILEKSLIDNRKPHIV
....|.||.|.||||.|||..| .|| .| . .|.| |...||.||.|.  |.| . .     | ..||.| . .....||||||.|||.. |..| ...
aqrslafEkasvlFnlaalysqiaasqnrssdeglkaAvkyfqrAaGafeylkenflhapse.D.lspetlkvlvklmlAqAqecflekaildkkkdsli

AKVTAQIVVYYGAALAALLTGGDDGPvaqvidssVYKLWKKYVRFKINYLTCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINE
||..||.. .|  ||.|| .              . | |.|.| .| .|.... ..||....|||...||... .|.. ..|.||.|..|.. .. |..|
aklaaqvadlYeealealqesptktg........ipkewaklvqvKaeyfkAlahyyqalaleekkkyGeaiarLqeAlellkeaqklakkckskselle

SLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSD--EEHAGPDIFARLVPMKAHEASSLYSEEKAKLLRK
.|... .....| ..|...|.|||.| ||. ... ....|.||. . ..  .  ... |.|.|..|||...|||.||||||||||.|.
dlkelkerikekleeaekdNdfiyleevpdeveltsikkaklvkalpinellsltkekgedlfkklvPiavheaaslyseekaklvrd
ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV 419-705 1.9e-60 192.6 Pfam-A 4-295 (296) alignment 
Range on Protein: 419-705
Range on HMM: 4-295/296.0
ANKLPQGIVDRCAALNANkTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQSATG--VQRTPNAHIT-ELSREFQKYSEAHARAGESNNT
 ..||. .......|...  .|..|.|....|.|  ..||. | |....|..|.. .....|  |   .|.| .. | || .| .|| ||.. | ||...
plglpesllekaeelrse.ggiesleeslddleelkqavesildeakeqLdeeesedeklrskygarwtrqpsseltaelreelrkyreaLeeAsesDsq

LRKAMSLHVNNLKILARPLPEIQQLMPKLS--SELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVI--AHGGQEGLQALFATELGKH
||...  . ..|..|. |  |.....|. |  .. ...| ..... .|.|.|..||.||..  .|. .|..|||.  .|  .. ..  ...||..||.|.
lrskleeieedlalLsspeeeleaslpssspeesdevseqikrlrelleklnllkaeRaklleeLkekihdddiskilielnkksssneeqlfeeeLekf

DKITELLDQNMVAQGNILQALTENYAKAAPVlKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEE
|. .| |.|.. .| ..|..|.| ... . . |. ...|..||.....|...||.|..| .. ..||.||..|. ....|... ..  . . .|
dplqerleqsiskQssllkelkeaneeflqd.kkskyekkerekvlqklenaydkykelssnleeglkFYndLlkileslrknvkdfvnarrsE
0050432 (Phosphotyrosine protein) phosphatases II 1496-1792 2.3e-48 160.5 In-house 16-301 (308) alignment 
Range on Protein: 1496-1792
Range on HMM: 16-301/308.0
TDEKTTKYFQKEVESYEKLLENlhvkmLNGKTQLGAKWQELQQKLDkeaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLdKQTDDYINAAYMKNLS-A
 .. ......  |... ||||.     ......| . ..||... .     ...|..  .   .|||. |.||||| |||| ....||||| |..  |  
dtsilvsslklsvldllkllek.....aldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssk

GCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALD-QPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLK
    ||..| | |||..||| |.| ...|..|.| .. |     ...|||  |. ....|...|||.|....|...  ..|.|...| . .. .  .. .
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhyt

QWTK-GAPAQLLGVAENALETHRQRckaanaPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLC
 |   |.| ..  . .   . ....      |..| .  |  |  |.  ..  .. ..  | ..   ..  ... ..  || ..  .   ..  ....|.
nWpdhgvPpspeilldflelvrksl......pggpivVHCsaGvGRtGtfi..aldllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

NAHN
 ...
ylkl
subfamily_PTPN6_pd Subfamily PTPN6 1501-1770 1.5e-29 98.0 In-house 2-274 (306) alignment 
Range on Protein: 1501-1770
Range on HMM: 2-274/306.0
TKYFQKEVESYEKLLENlhVKMLNGKTQLGAKWQELQQKLDKEAAAnkRSTTIAKLFPEKNRSLDCLPYDHARVKL---DKQTDDYINAAYMK-NLSAGC
|.  .||.|. .. ||.   .   .|. .  ...||||.  |.     |. .  .   ||||    ||.||.||.|   . . .||||| |.| ..   .
tsllakeieqrvselek..eeeslekagfeeefeelqqeeakklls..rkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd

PNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPThYDDYTVTCLKVQQLSHCSEYQLKLS-MHGADAVLDLSLLQLKQW
 ..| .|   ..|..|||.|.| |.|| .| . . .|       .|||.. .... | ...||... ..|..    .|..| .. ..   ..  .. |.|
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksW

TKGAPAQLLGVAENALETHRQRCKAAN-APQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQ
   .  .  |.  . ||. ... .  . | . |... |  |  |   .   |  |.  . ..  |   ||. . .   |.
PdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi..viDillkliekkgldadidiqklvksvre
0045450 (Phosphotyrosine protein) phosphatases II 1508-1786 4.7e-43 143.5 In-house 8-300 (307) alignment 
Range on Protein: 1508-1786
Range on HMM: 8-300/307.0
VESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLSA-------G
.....|||  .....|...| | . ...|..  ..    ...|..  .   .|||. |.||||| ||||       ...||||| |..  .         
fidalkllllvllllldfltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

CPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH-GADAVLDLSLLQLKQ
. .||..|.|.|.|..||| |.| ......|.| .. ||     ..|||.  ...  |...|||.|....|...  ..|..... | . .. .  .. . 
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WTKGAPAQLLGVAENALETHRQRCKAAnAPQSPLIMNCLTGSERSELVAIgvCAIIATQNKQPIL---LNTIDVWSRICAQRQNSLRDSAILEQSMQIV
|  .   . .  . . .|  |. ...   ...| .  |  |  |.  ...  . .. .| ..      ..  ...... .|| ..      ... ....
wpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfia..aylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0051299 (Phosphotyrosine protein) phosphatases II 1509-1774 3.8e-46 153.2 In-house 5-270 (288) alignment 
Range on Protein: 1509-1774
Range on HMM: 5-270/288.0
ESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKeaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMkNLSAGCPNFIVAQT
 |.|.||. .. ...||.|.| . ..||...| .    ...|... .   ||||. |.||||| ||||       ..||||| |. ..      ||..|.
isveellklvlkllangltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH----GADAVLDLSLLQLKQWTKGAP
| |||..||| |.| ...|..|.| .. ||    ...|||.  .... |.|.|||.|....|...  ..|... .    | . ..    .. ..|     
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

AQLLGVAENALETHRQRCKaanAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKqpILLNTIDVWSRICAQRQNSLR
 . .    . |.  |. ..   ....| .  |  |  |.  ...  ...   ...    ..  ... |.. || ..  
pdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvq
0039614 (Phosphotyrosine protein) phosphatases II 1509-1783 4.3e-43 143.2 In-house 14-282 (297) alignment 
Range on Protein: 1509-1783
Range on HMM: 14-282/297.0
ESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDkeaaaNkRSTTIAKLFPEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLSAGCPNFIVAQ
.... |   |... .|.||.| . ..||..  .     . .|..  .   .|||. |.||||| ||||         .||||| |..  .  ...||..|
iplsvldlllllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

TPQPNTINDFWSMIWSEKSRTVVCLHTPNEL---FDPYWPQALDqptHYDDYTVTCLKVQQLSHCSEYQLKLSMhgADAVLDLSLLQLKQWTKGAPAQLL
.|.|.|..||| |.| ......|.| ...||   ...|||.  .    |.|.|||.|||..|...  ..|....   . .. .  .|   |  . . ..|
gPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

GVAENALETHRQRCKAAnAPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSM
 .  ..||  |......  .. | .  |  |  |.  ..  .. .. .| .    ..  ......  || ..      ... .
ellleflelvrealael.pkggpvlVHCsaGvgRtGtfi..aaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1509-1770 1.7e-27 91.3 In-house 5-257 (318) alignment 
Range on Protein: 1509-1770
Range on HMM: 5-257/318.0
ESYEKLLENLHVkmlNGKTQLGAKWQELQQKLDKEaaANKRSttIAKLFPEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAGcPNFIVAQT
| .|. ...|.    .|...| . ...|... ..   .. .|  . .    |||  . |.|||.||||...    . ||||| |.    .   ..| ||.
edleshvrrlre...sGelllseeyerlsrseetv..tslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqa

PQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPAQL
| |.||.||| |.|  .|...| |   .|      . |||.  .....|.. .|.  .  .||.    ..|.. .. ... .    .  .|.  | |.. 
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

lgvaENALETHRQRCKAA-NAPQSPLIMNCLTGSERSelvaiGVCAIIATQNKQPILLNTIDVWSRICAQRQ
     . |.  ||  ||  .. ..|... | .|  |      ||  .. .. ..    ...||.  .   |.
....aslldlvrqvskaqqksgagpivvhCsaGvGrt.....GvfiavdillerikaealvDvfqtvkqlre
subfamily_PTPRG_pd Subfamily PTPRG 1509-1770 1.9e-26 87.4 In-house 4-267 (563) alignment 
Range on Protein: 1509-1770
Range on HMM: 4-267/563.0
ESYEKLLENLHVkmlNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKlfPEKNRSLDCLPYDHARVKLDKQTD-----DYINAAYMKNLSAGcPNFIVAQ
. ..| . .||    .|.. . .....||..  ..    . |        .||| |. ..||..|||| . ..     ||||| |..    .  .||..|
kefakhvaslha...dgdigfseefealqsetiskdldaehsqkpen..krKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks.kafiatq

TPQPNTINDFWSMIWSEKSRTVVCLHT----PNELFDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSM----HGA--DAVLDLSLLQLKQWT-
 | ..|..||| ||| ... ..| .       ..  | |||.  |.. .|.  .||  . ..|.  .. .|..      ..   | ..     .  .|  
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

KGAPAQLLGVaenaLETHRQRCKAANAPQSPLIMNCLTGSERSelvaiGVCAIIATQNKQPILLNTIDVWS---RICAQRQ
.|.| . | |    |   ... .| .|   |... | .|  |.     |.  .. |  ||    |...|.    .| |||.
hgvPehslpv....LifvkkssaankaeaGPivvHcsaGvgrt.....GtyivldtllkqiqqenavnvfgflkhiraqRn
0043336 (Phosphotyrosine protein) phosphatases II 1511-1775 1.6e-41 138.0 In-house 4-262 (278) alignment 
Range on Protein: 1511-1775
Range on HMM: 4-262/278.0
YEKLLENLHVKMLNGKTQLGAKWQELQQKLDkeaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMkNLSAGCPNFIVAQTPQ
...||. |  ..||.|| | . ..||..        . .|... .   .|||. |.||||| ||||.  .    .||||| |. ..   ...||..|.|.
vkdllkallelllnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPl

PNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPqalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGV
|.|..||| |.| ....|.|.| .. ||    ...|||   .... |.|.|||.||...|...  ..|.....| . ..    .. . |  .     |  
petvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

AENALETHRQRCKaanAPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRD
  . |.. |....    ...|..  |  |  |. ...  .. .. .| .    ..  ......  || ...  
lldflkavreale...dsngpvlVHCsaGvgRTGtfi..alyllleqlekeggvdleeavkelreqRpgavqt
subfamily_PTPRA_pd Subfamily PTPRA 1512-1771 3.7e-19 63.8 In-house 17-276 (330) alignment 
Range on Protein: 1512-1771
Range on HMM: 17-276/330.0
EKLLENLHVKMLNGKTQLGAKWQELQQ-KLDKEA-AANKRSTTiaklfpEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAgCPNFIVAQTP
||| |...... .   ..  ... |   ...    .|.|          |||| .. ||||..|| | .    .. |||||....       .|| || |
ekleeeirirsaddnklfreefnalPagpiqatlelaskeenk......eknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGP

QPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLS----MHGADAVLDLSLLQLKQWTK-GAP
. .|..||| |||  || |.| |   .|        |||.  .    | . .|.  ... | . .  .. .     .   ...  .. . .. | . | |
keetvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

AQLLGVAENALETHRQRCKAANapqsPLIMNCLTGSERSELVaIGVCAIIATQnKQPILLNTIDVWSRICAQRQN
..  |. .   . .... . |.    |... | .|  |.    | . |...   |   ...  .. .|. .|| .
fepiGmlkllkkvkklnqqsag....pivvhcsaGvGrtGtf.ivldavlerv.kaerkvdvfefvkrlrlqrpq
subfamily_PTPN23_pd Subfamily PTPN23 1514-1798 2.5e-117 385.8 In-house 2-288 (288) alignment 
Range on Protein: 1514-1798
Range on HMM: 2-288/288.0
LLENLHVKMLNGKTQLGAKWQELQQKLDKEaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDF
|.|.|..|||.|||.|..|..||.|| |||  |.|||..||||..||||| |.|||||.||||....||||||...|.||.|||.||..|.|...|.|||
lveelqrkmldgktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WSMIWSEKSRTVVCLHTPNELFDP----YWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPA------QLLGV
|.|....||...|.|....||..|    |||.. .......|..||. .|.......|..|||....|||| ..|.|||..|.. |.||      |.|..
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

AENALETHRQRCKAanapqsPLIMNCLTGSERSELVAIGVCAIIATqNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRG
.|.|.|......|.      ||...|..|..|....|. ..|.... .|...||..|.|.||...||.........|..|...||..|..||.|||
vesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1514-1770 2.1e-22 74.6 In-house 10-263 (319) alignment 
Range on Protein: 1514-1770
Range on HMM: 10-263/319.0
LLENLHVKMLNGKTQLGAKWQELQQKLDKeaaanKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNT
| |.|.    .|.|.|   ...|..  ..     . ...  .   .|||  . |.||..||.|    ...  |||||...        .|| .|.|  ||
Lkerlkalastgetllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlent

INDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQAldQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADA-VLDLSLLQLKQWTK-GAPAQLLGVA
|.||| |.| |.| .|| |   .|        |||..  ....|  ..|| .. ..|..    .|||  . ..    ...  | ..|.  . | ..... 
iedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

ENALETHRQRCKaanAPQSPLIMNCLTGSERSElvAIGVCAIIATQNKQPillNTIDVW---SRICAQRQ
.   . .. | |     . |... |  |. |    .  |  ..  . |.    ...||.   ||. .||.
dllkrirksrek...tqsgPivvhCsaGvGRtG..tfivldamlervkee...gvlDvfstvsrlRtqRn
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1518-1771 5.4e-31 102.9 In-house 18-268 (298) alignment 
Range on Protein: 1518-1771
Range on HMM: 18-268/298.0
LHVKMLNGKTQLGAKWQELQQKLDkEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDF
  ||  .. |.. ...|.|..  . |  ... . . ..   .|||  | ...|..|| | |    .  |||||..... . | . ||..|.| ..|..||
aavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedF

WSMIWSEKSRTVVCLHTPNEL----FDPYWPQAldQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAEnaLE
| |.. |.. |.| |.. .||    .  |||.   . ..|.. ||. |. .. .     .||.| .  .    .  |.  .|. ||.|..   | .  | 
WrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld..ll

THRQRcKAANAPQSPLIMNCLTGSERSELVaIGVCAIIATQNKQpillNTIDVWSRICAQRQN
.. .. .  .| ..|.|..|  | .||    | . ...   .|.    ...||.  . . |..
rkvra.sqqqagnkpvivqCsaGvgRsGtf.iaidsvlervkke....qvvDvfqvvkvlRkk
subfamily_PTPRD_pd Subfamily PTPRD 1518-1737 2.1e-30 100.9 In-house 14-230 (564) alignment 
Range on Protein: 1518-1737
Range on HMM: 14-230/564.0
LHVKMLNGKTQLGAKWQELQQKldKEAAANKRSTTIaklFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDF
..    |.....  ........  ..   .. .  .     .|||  . ..||| ||.| |    .  ||||| ...       ..| .| | ..||.||
vaklkansdlkfeeeykkieeg..qqftweaankpa...NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedF

WSMIWSEKSRTVVCLHTPNEL----FDPYWPQAlDqPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQllgvAENALE
| |.| ..|.|.| |   .|     .. |||.  . ...|...|||  . ..|.. .  ..||...  . .      .  .|  .|.| .    |.. |.
WRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes....atslLd

THRQRCKAANAPQSPLIMNCLTGSERSEL
  |.  ....  . |..  |  | .|.  
lirkvralnepdagPivVhCSaGVGRTGt
subfamily_PTPN14_pd Subfamily PTPN14 1519-1750 1.9e-22 74.7 In-house 12-258 (300) alignment 
Range on Protein: 1519-1750
Range on HMM: 12-258/300.0
HVKMLNGKTQLGAKWQELQQKLDKEAAAnKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK---QTDDYINAAYMKNLSAG-CPNFIVAQTPQPNTINDFW
..|.|. | . |  ..| ..   |.. | . ||.  .   ||||  | |||...||.|     ....||||. .|   .|   ..||||.|...|..|||
rakilekkleegkvfteyeripkkreda.llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfW

SMIWSEKSRTVVCLHTP----NELFDPYWPQA--LDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAE--N
 |.| .. . .| |       .|    |.|.     .  ... . ||   ... . .   .|||    .    ..  || . |. .| |  . |  .  .
qmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLe

ALETHRQRCKAAN---APQSPLIMNCLTGSERSELVAIGVCAIIATQN
 ..  |.. .  .     . |... |. |  |.  . .    | . ..
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatleh
subfamily_PTPRN_pd Subfamily PTPRN 1521-1737 4.1e-21 70.0 In-house 23-240 (297) alignment 
Range on Protein: 1521-1737
Range on HMM: 23-240/297.0
KMLNGKTQLGAKWQELQQKldkEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSM
. |. |..| ..|. | .    ||  . .... |. . .|||| ..|||||.||||....    .|||||. . .     | .| .|.| ..|. ||| |
dhlknkdrlekewealcay...eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqm

IWSEKSRTVVCLHTPNE----LFDPYWPQALDQptHYDDYTVTClkVQQLSHCSEY------QLKLSMHGADAVLDLSLLQLKQwtKGAPAQllgvAENA
.| . .  .| | . .|      . |||.   .   |. | |    | .   | .|         |  . . .|  .  |  ..  .|.||.    | . 
vweqGvvvivnltrleeegvkqckrywpdeGse..vyhiyevhl..vsehiwcddylvrsfylknlqtsetrtvtqfhflswpe..egvPas....aksl

LETHRQRCKAANAPQSPLIMNCLTGSERSEL
||  |.  |.     .|... |  |. |.  
lefrrkvnksyrGrscpivvhcsdGaGrtGv
0036941 (Phosphotyrosine protein) phosphatases II 1522-1806 3.1e-47 156.7 In-house 5-290 (297) alignment 
Range on Protein: 1522-1806
Range on HMM: 5-290/297.0
MLNGKTQLGAKWQELqQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEK
.|.....|  ...|  ..|..  .  ..|... .   ||||. |.||||| |||||.. .||||| |. ..   . .||..|.|.|||..||| |.| ..
llekllflalllkef.eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqn

SRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQ--LSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCK
....|.| .. ||    ...|||   ...  |.|.|||.|.|..  |...  ..|.....| . .. .  .. . |    . .      . .|  |...|
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

AAnAPQSPLIMNCLTGSERSELVAIGVCAIIATQNK-QPILLNTIDVWSRICAQRQNSLRdsaILEQSMQIVLCNAHNVLNKRGIMTSYQMK
..  ...| .  |  |  ||  ...  ...   ..|     ..  ...  .  || ..      ||| ...  . .. ...|. ..  ....
ll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq...tleqyrflyeallellkkkltkepllklv
0047943 (Phosphotyrosine protein) phosphatases II 1523-1786 3.6e-46 153.2 In-house 8-268 (273) alignment 
Range on Protein: 1523-1786
Range on HMM: 8-268/273.0
LNGKTQLGAKWQELQQKLDkeaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKS
|.|.|.| .....|..  .      ..|... .   .|||. |.||||| ||||. ...||||| |. ..    ..||..|.| |||..||| |.| ...
llgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnv

RTVVCLHTPNEL----FDPYWPQALDQ-PTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAA
|..|.| .. ||    ...|||.  .. .. |...|||.|.... ...  ..|.|...| . ..    .. . |      . |    . .|  |. ..|.
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

NAPqSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIV
. . .| .  |  |  |.  ..  .. ..  | .    ..  ... ... || ..      ... ....
psn.gpvvVHCsaGvgRtgtfi..aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 1524-1790 9.6e-45 148.6 In-house 15-276 (317) alignment 
Range on Protein: 1524-1790
Range on HMM: 15-276/317.0
NGKTQLGAKWQELQQKldkeaA-AnKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIW
...|.|   ...|..           .|... .  ..|||. |.||||| ||||   .    .||||| |. .    ...||..|.|.|||..||| |.|
sdftalleefedllsl.....kld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvw

SEKSRTVVCLHTPNEL----FDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRC
 ......|.| .. ||    ...|||.  .....|.|.|||.|....|...  ..|... .| . .. .  .. . |. . . . .    . ||  |. .
eqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

KaanAPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNA
.    |..|..  |  |  |.  ..  .. ..  | ..   ..  ... .. .|| ..    . ... ....|.  
e...dpggpvlVHCsaGvgRtGtfi..aaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 1524-1769 8.8e-27 89.0 In-house 17-262 (307) alignment 
Range on Protein: 1524-1769
Range on HMM: 17-262/307.0
NGKTQLGAKwQELqQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWS
...|. | . .|  .|| ..    . ...  |    |||. |  ..|. |||| |    .. ||||| ..|       .||.|| |  .||.||| ||. 
krdtdfgla.key.ekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiae

EKSRTVVCLHTPNELFD----PYWPQAldQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGAD-----AVLDLSLLQLKQWTkgaPAQLLGVAENALETH
 .. ..| |   .|  .     |||.   . ..|.|  |.. . .. |.  . .|..|. ...     .   .   . ..|      .   ||.  |.  
qevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk...DskvPevargllkli

RQRCKAANAPQSPLIMNCLTGSERSELVaIGVCAIIATQNKQpillNTIDVWSRICAQR
.|  .  .  .||... | .|..|| .. . .. ..  ...     ...|..  ..  |
eqvrelyklnrsPivvhCsaGvgrsgif.valdsllqqlkae....dkvdifetvkdLr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1524-1787 1.7e-22 74.6 In-house 13-280 (290) alignment 
Range on Protein: 1524-1787
Range on HMM: 13-280/290.0
NGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT------DDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMI
||...   ....  ..||. .  ..  . ...   ..||. ....||  |. | . .      ..||||.|.|. .    ..|..|.| .||. |||..|
nghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkli

WSEKSRTVVCLHTPNEL----FDPYWPQAlDQPThYDDYTVTCLKVQQLSHCSEYQLKLSMHGA-DAVLDLSLLQLKQWTKGA-PAQLLGVAENALETHR
| ||.  .| | . .|        |||.. |. . |. .... |. ..|..  | .|..  . . .|   .  .|.. | .    ..  ..     |  .
wqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

QRCKAANapqSPLIMNCLTGSERSELVaigvCAIIATQNKQP--ILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVL
.. |  |    .... |  .  || .     ||.  | ||       . ..|  .   |. .|.     ..  .||||
tqrkrgn...tsivvHCSdtvgrsavf....caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1524-1737 2.3e-20 67.6 In-house 7-226 (287) alignment 
Range on Protein: 1524-1737
Range on HMM: 7-226/287.0
NGKTQLGAKWQELQQKLDKEAAANKRSTTIAKlfPEKNRSLDCLPYDHARVKLDKQ---TDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSE
. | .. .. . |..  .  .|  |... .|.   .|||  | ||.|..|| | ..     ||||| |.        .||.||.| . |..||| ... .
rvkddvdkevdalkedsesstatfkaaeelaa..vkknryadvlPiddtrvllsaegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravlet

KSRTVVCL-HTPNEL---FDPYWPQAlDQPTHYDDYTVTCLKVQQLS--HCSEyQLKL-SMHGADA--VLDLSLLQLkqWTKGAPAQLLGVAENALET--
.| .|. . .  .|       |||.  ..|     |.|. |. ....  ..    |.|  ... .|  |  | ||.     |...   .|..  .|.   
rsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvr.alrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkq

HRQRCKAANApQSPLIMNCLTGSERSEL
| .  . |.    ||.. . .|  || .
hielardase.vGPlvvhddvGiGrsGi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1525-1771 2.4e-28 94.0 In-house 19-257 (288) alignment 
Range on Protein: 1525-1771
Range on HMM: 19-257/288.0
GKTQLGAKWQELqQKLDKEAAANKRSTTIAKlfpEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSE
..|..  ... |  .|.|. . .. . .  .   .|||  . ||||. ||||.|    .. |||||.|...   .  ..| .|.| ..|.|||| ... .
nrtgfseeynsL.aalektksvtagrlavna...kknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyen

KSRTVVCLHTP----NELFDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSmhGADAVLDLSLLQLKQWTK-GAPAQllgvAENALETHRQRCK
|. |.| |       ..  . |||.| |.|..| . ||| .....| .  . .| |        |..  .| . |.  | |..    ... ||  ||   
ktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPes....kapllellrqvkv

AANAPQSPLIMNCLTGSERSELVaIGVCAIIATQNKqpilLNTIDVWSRICAQRQN
| .| . |.|. |  |  |.    | . |.| . ..     ..||| . ..  |..
anqadtgpiivhCsaGvGrtgtF.ialdalidavee....edyiDvagtvaklRkq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1525-1774 4.4e-23 76.7 In-house 18-259 (287) alignment 
Range on Protein: 1525-1774
Range on HMM: 18-259/287.0
GKTQLGAKWQELQQKLDKEaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRT
|...   ... |.|  ..|   ..   .||.   .|||. . |..|  || | .. .|||||....  .    .||.|..|  ||. .|| .|. ..  .
gnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvta

VVCLHTPNE----LFDPYWPQALDqpTHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDLSLLQLKQWTKGA----PAQLLGVAENALETHRQRCK
.| |   .|        |||.     . . .|... |. .. ... | .|..  .. |.. . .   |. .| .      |.  | | |.   |.|.| .
ivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn

aanapqSPLIMNCLTGSERSELvaigVCAIIATQNKQPiLLNTIDVWSRICAQRQNSLR
      ..... |  .  || .     ||.  | ||      .||| . .  ||.    
......tsivvhCsdtvGrsam....fcaaattinkck.teGviDvfqvlksqriqkpg
subfamily_PTPN12_pd Subfamily PTPN12 1526-1771 5.9e-26 86.0 In-house 7-255 (290) alignment 
Range on Protein: 1526-1771
Range on HMM: 7-255/290.0
KTQLGAKWQELQQKLDKEAAAN--KRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWS
. .. ...|.|..  .|  | .  ..... ..   .|||  | ||||..||.| |..    .||||| ..|.  .|  ..| ||.| |.|..||| |||.
eeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv.egkleyiaaqgPLpktlddfWrmiwe

EKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLSH-CSEYQLKLSMHgaDAVLDLSLLQLKQWT-KGAPAQLLGVAEnALETHRQR
 . . || .    ||     . |||.  ..........||. . .....     .||. ..  ..   .  .. ..|  .| |..   . |  .|. |..
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssakslle.lielvrel

CKaanAPQSPLIMNCLTGSERSelVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQN
 .   . ..||.. |  |  |    .| .  .. .. |. .. ...||.. .   |..
qe...sedaPlvvhCsaGvGrt..Gtiiaidyvrellkaekipeeldvfdlvlelrkq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1526-1734 2.7e-21 71.0 In-house 21-229 (305) alignment 
Range on Protein: 1526-1734
Range on HMM: 21-229/305.0
KTQLGAKWQELQQKlDKEAAANKRSttiAKLFPEKNRSLDCLPYDHARVKLDKQTD--DYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSR
...| |....|... ..    .|..   |.   .....   |. |. ... ....|  |||||.|..  .    ..||||.| .||..||| .|. || .
dkgleaqykslyee.eesidvgkke...ankaknrlkeitlldddriiltekeslddsdyinasyvdgykr.kkkyivaqgPlkntvadfWrliveekvs

TVVCLH----TPNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSM-HGADAVLDLSLLQLKQWT-KGAPAQllgvAENALETHRQRCKAA
|.| |       ..    |||..  .........|.    .. |   | .||.|. .. .    .. .|| .|  .| | .    |   |.  ..  |. 
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf....atsllslikrvqkdq

NAPQS-PLIMNCLTGSER
.  .  ||.  |  |  |
kkdkgvpllVhCsagvgR
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1526-1662 1.2e-14 48.8 In-house 14-154 (301) alignment 
Range on Protein: 1526-1662
Range on HMM: 14-154/301.0
KTQLGAKWQELQQKLDKEAAANKRSTTIAKlfpekNRSLDCLPYDHARV------KLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWS
.... ....||... ||..  . ...  |      ||  .  .||. |.      .||... .|||| |... |    .||.|| |  .|. ||| .|| 
snkfeeqykelkegedksctvglseenkal.....nrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwq

EKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQL
||  ..| .   .|        |||..  . ...   |||  . | .
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvy
subfamily_PTPRB_pd Subfamily PTPRB 1528-1771 8.8e-29 95.4 In-house 26-263 (293) alignment 
Range on Protein: 1528-1771
Range on HMM: 26-263/293.0
QLGAKWQELQQkLDKEaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSR
..  ...||.. ..|.   .. ... ..   .|||  . |||||.||||    |....||||| |......   .||..| | |.|..||| |.| .||.
rfseeyeelka.vgkd...qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkss

TVVCLHTPNE----LFDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMhgADAVLDLSLLQLKQWTK-GAPAQLLGVAENAlETHRQRCkAAN
..| |    |      . |||.  ..|. | | .|| .. ..|..    .||..   ...  ..  .. . |.  | | .   . .   .| |..    .
iivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv.rtvreai.ekt

APQSPLIMNCLTGSERSElVAIGVCAIIATQNKqpilLNTIDVWSRICAQRQN
| ..|... |  |  |.  . | .  .. . ..     ...|. . ... |..
askrPivvhCsaGvGRtG.tfialdrllqaiee....edyvdifgivaelRee
0046845 (Phosphotyrosine protein) phosphatases II 1530-1777 6.8e-45 149.0 In-house 3-261 (284) alignment 
Range on Protein: 1530-1777
Range on HMM: 3-261/284.0
GAKWQELQQKLDKEAaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLS----AGCPNFIVAQTPQPNTINDFWSMIWSE
 ....||..   |     ..|.....   .|||. |.||||| ||||.      ...||||| |..  .      ...||..|.| |||..||| |.| .
eeefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSRTVVCLHTPNEL----FDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCK
..|..|.| .. |     ...|||.  ... .|.|.|||.|.... ...  . |.|...|  . .. .  .. ..|      . .    . |.. |. ..
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

AaNAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKQ-PILLNTIDVWSRICAQRQNSLRDSA
. . ...| .  |  |  |.  ...  ...   .... .. ..  ....|.. || ..    .
n.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
subfamily_PTPN1_pd Subfamily PTPN1 1531-1771 7.7e-24 78.9 In-house 6-249 (290) alignment 
Range on Protein: 1531-1771
Range on HMM: 6-249/290.0
AKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHT
 ...|. ....|||   . ...  .   ..||  |  ||||.|.||...  |||||. ..   |   ..|..| | |||.. || |.| .||..|| |  
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeak.rsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

PNE----LFDPYWPQALD-QPTHYD--DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRcKAANAPQSP
  |        ||||  . .   ..   ..|. .. .. |.    .|.|    ..   ...     .|.  .  .  .   . |   |.   . .  . |
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGp

LIMNCLTGSERSELVAIGVCAIIATQNKQPilLNTIDVWSRICAQRQN
 .. | .|  ||  ...  . ..  ..|.   |...|.  .... |. 
avihcsaGiGrsGtfclvdtclvliekkdd..lssvdikkvllelrky
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1532-1740 1.6e-22 74.9 In-house 16-228 (281) alignment 
Range on Protein: 1532-1740
Range on HMM: 16-228/281.0
KWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC
 ..|  .|| .    |  . . |.   .|||  .   ||..|||.    .... ||||| ... .. |  ..|..|.| |.....|| |.|..| ...| 
GfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweqkvsaivm

LHTPNE---L-FDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVlDLSLLQLKQWT-KGAPAQLLGVAENALETHRQRCKAANapqS
.    |   |    |||.  .. ..| |.||. .. .. ..  | ..||........ ... |. ..|  .|.||.   . |   | .. . |  .    
vtreieagklkChrYWPdd.nselkygdvtvkstaeeekatyierkfkleresgetr.eveqlaytaWPdhGvPattkellefrkevlkltekktk...a

PLIMNCLTGSERSE-LVAI
||.. | .|  |.   .|.
plvihCsaGvGrtGtyial
DSPc_SM00195 1536-1770 1.5e-40 134.5 In-house 5-242 (263) alignment 
Range on Protein: 1536-1770
Range on HMM: 5-242/263.0
LQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP
  .||....  .. .... |   .|||. ..||||| ||||.|.     .||||| |.|       ..|..| |.|.|..||| |.| ||....|.|  .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmltee

NEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLS-HCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAP---AQLLGVAENALETHRQRckaanapQS
.|      | |||.  .... .....|.. .|.. . ..  ..|.|...| .   ..  .| |.|.. |.|    ..| . . . .....        ..
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sg

PLIMNCLTGSERSELVAIGVCAIIATQNKQPilLNTIDVWSRICAQRQ
|..  | .| .|.  ..   ...   ....   ..  ......  || 
pivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRp
PTPc_SM00194 1536-1770 1.5e-40 134.5 In-house 5-242 (263) alignment 
Range on Protein: 1536-1770
Range on HMM: 5-242/263.0
LQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP
  .||....  .. .... |   .|||. ..||||| ||||.|.     .||||| |.|       ..|..| |.|.|..||| |.| ||....|.|  .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmltee

NEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLS-HCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAP---AQLLGVAENALETHRQRckaanapQS
.|      | |||.  .... .....|.. .|.. . ..  ..|.|...| .   ..  .| |.|.. |.|    ..| . . . .....        ..
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sg

PLIMNCLTGSERSELVAIGVCAIIATQNKQPilLNTIDVWSRICAQRQ
|..  | .| .|.  ..   ...   ....   ..  ......  || 
pivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1537-1771 5.7e-22 73.2 In-house 29-262 (297) alignment 
Range on Protein: 1537-1771
Range on HMM: 29-262/297.0
QQKLDKEAAANKRSTTIAK--LFPEKNRSLDCLPYDHARVKLDKQTDD----YINAAYMKNLSAgcpNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHT
....    .|| ...| |.  .  ||.|  . ||||  ||||    ||    |.||...|       ..|  |.|...|..||| |.. |.  |.| |  
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnd

PNE---LFDPYWPQALDQPthYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQ--LLGVAENALETHRQRCKAANapQSPLI
 ||       ||..   ..  . | .|. | |.. .  .. .|...   | |   .   |  .| . |  .        . ..  |.  .  .  ..||.
dnerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna..egPll

MNCLTGSERSElVAIGVCAIIATQNKQpillNTIDVWSRICAQRQN
. ||.|  |   | . .  ..|  ...    ...|..  .   ||.
vhclaGvGrtg.vlltidsvvaeakre....kevdifglvkklrqe
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 1537-1659 5e-07 21.5 In-house 10-126 (275) alignment 
Range on Protein: 1537-1659
Range on HMM: 10-126/275.0
QQKLDKEAAANKRSTTIAKlFPEKNRSLDCLPYDHArvkLDKQTDDYINAAymKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD
|| ||     ...   . .   ||||  .   .|.    ||.. ....  |  . . .   ||...|.|. .|  |.  ..|  . .||||| .|.|   
qqdlddlnlddekierfir.ngeknrftnvtcfdei...ldrenqeffvha..ntfrtpygnflisqapndstnadhlhllwiynvqtvvclvlpeeagg

PYWPQALDQPTHYDDYTVTCLKV
 . |.  .  | .. | .  . .
yfvpkegetftsfqkyqiktigi
subfamily_PTPN9_pd Subfamily PTPN9 1538-1698 9.9e-20 65.7 In-house 23-191 (297) alignment 
Range on Protein: 1538-1698
Range on HMM: 23-191/297.0
QKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE
... .|... .  ..  ..  ||||  | | ||..||.| |.    . ||||| ..         || .| | ..|..||| |.| .. ...|      |
aeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvve

----LFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPAQ
        |||.  .. ... |..|. ..|.. ..  . .|...    .    ..  |.  |   | | .
rgrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss
subfamily_eak_pd Subfamily eak 1539-1659 1.4e-07 25.2 In-house 34-159 (332) alignment 
Range on Protein: 1539-1659
Range on HMM: 34-159/332.0
KLDKEAAANKRSTTIAKLFPEKNrSLDCLPYDHARVKLD---KQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE--
.||.   .   | |      ..|  .. .|||.  |.|    .  . ||||. ..    |  ..|..  .. . .  || |.  .|| ..| |    |  
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevG.rkyiltGiasedkvfafwqmvleqkspaivqlledvelk

--LFDPYWPQALDQPTHYDDYTVTCLKV
   .| |.|.   .  ..  . |.. . 
leksdkyfpdktreelkfGildverkef
subfamily_ptpA1_pd Subfamily ptpA1 1540-1642 3e-15 50.9 In-house 30-138 (418) alignment 
Range on Protein: 1540-1642
Range on HMM: 30-138/418.0
LDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNlsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL-
|..    .. |    |    |||  . || .|.||.|    ||.  ||||| |.    |   .||..| | |||| ||| |.| .. | .| |   .|  
leesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresenc

---FDPYWPQA
    | |||. 
rikcdrywpeq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1541-1752 1.1e-18 62.2 In-house 5-229 (270) alignment 
Range on Protein: 1541-1752
Range on HMM: 5-229/270.0
DKEAAANKRSTTIAKlFPEKNRSLDCLPYDHARVKLDKQTD----DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN----
|||.. ..   ..|.  .. ||. | ||  ..||.|.. ..     |||| |..  .    ..| |..|.|.|...|| |||.||....| .   .    
dkeetsesdlpeaar.gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

ELFDPYWPQALDQPTHYDDYTVTCLKVQQLSH--CSEYQLKLSMHGADAvlDLSLLQLKQWT-KGAPAQLLG--VAENALETHRQR---CKAANAPQsPL
.  . |||.  .. ... | ... |....  .      .|.|  .|      |   . ..|  .|.| .  .   ... |.. |.    .|  .  . ||
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer..rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.Pl

IMNCLTGSERSE-LVAIGVCAIIATQNKQ
.. |  | .|.  |.|.  .  .  ..|.
lvHcsaGvgRtGtlialDiavrlLeetkk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1546-1697 1.1e-16 55.6 In-house 22-172 (267) alignment 
Range on Protein: 1546-1697
Range on HMM: 22-172/267.0
ANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP-NELFDPYWPQALD
 .. |. ||.   |.||  | ||||..|| | .....||||.|..    .   ||| | |  ||| ||. .|  .|  ..| |..   .    .||  . 
sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmg

QPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGaDAVLDLSLLQLKQWTKGAPA
|  .|.| ||     ..        |.| ..  ..  ...|   |.|   .  
qakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintnn
subfamily_CG7180_pd Subfamily CG7180 1547-1735 4.7e-22 73.0 In-house 32-237 (296) alignment 
Range on Protein: 1547-1735
Range on HMM: 32-237/296.0
NKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD---PYW
..  . . |   ||||  ...|||..|| |.|    ...|||||.|.  .     ..|| ..|. .|...||.... |.. .|| |  . .       ||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk.keyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsyw

PQALdqPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH-------GADAVLD---LSLLQLKQWTK--GAPAQ---LLGVAeNALETHRQRCkAANAPQSPL
|.     ..| .  |  ....|...   ...||  .        .. . .   . |.||..|      |     |. .  .  .. |..    .  ..|.
pnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielr.rrvrlwrekv.dedpeegPv

IMNCLTGSERS
.. .  |. ||
vvvssdGasRs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1549-1770 3.3e-25 83.6 In-house 37-254 (315) alignment 
Range on Protein: 1549-1770
Range on HMM: 37-254/315.0
RSTTIAKLFpEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD----PYWP
|..     | .|||  . ||.|.|||||    |.  .|||||.|.| .      .| .|.|.. ...|||.|.. ||  |.| .   .|        |||
rvaretinf.kknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

QALDQPTHYDDYTVTCLKVQQLSHCSEYQLklSMHGADAVLDLSLLQLKQWTK-GAPAQlLGvaenALETHRQRCKAANAP-QSPLIMNCLTGSERSELV
.   . ...  . |. |.... .     .|   .  ...   ..  |...| . |.. | ..    .|    .  || | . . .|.. |..|  |. .|
drkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkq.ts....sllklikevkadngkkefsllvhcsaGvGrtGvv

aIGVCAIIATQNKQpillNTIDVWSRICAQRQ
 | .  ..|  ...    ...||.  .   |.
.isidevvaqikrt....rsvdvfnfvknlra
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1549-1771 2e-21 71.6 In-house 51-269 (319) alignment 
Range on Protein: 1549-1771
Range on HMM: 51-269/319.0
RSTTIAKLF--PEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHtpNELFDPYWPQA
   | | |    .|||  . |..|...|||..       |||||....        .| || |..||..||| |||  .. |.| |   ..    |||. 
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr.kdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplk

LDQptHYDDYTVTCLKVQQLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAenALETHRQRCKAANAPQSPLIMNCLTGSERSElVAI
 ..  ... . |    |.. .     ...|| .|    . ..    .. |  .| | .   .    |  . .  .  .  . .... | .|. |.  | |
ivi..keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlm..rlvkkvrhltskenhranivvhcsaGvGrtG.vyi

GVCAIIATQNKQpillNTIDVWSRICAQRQN
 . ...   ...    . .||.  .   ||.
vldvlldrmkee....kqvdvynfvrdlrqq
0040439 (Phosphotyrosine protein) phosphatases II 1550-1781 2.8e-37 124.1 In-house 4-237 (249) alignment 
Range on Protein: 1550-1781
Range on HMM: 4-237/249.0
STTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQ
|... .  ..|||. |.||||| ||||        .||||| |. ...  ...||..|.| |.|..||| |.| ......|.| .. ||    ...|||.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

alDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAAnAPQSPLIMNCLTGSERSelVAIG
  .... |.|.|||.|.|......  ..|.|.... . ..    .|   |      . .  . . .|  |. ....  ...|..  |  |  |.   .. 
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRt..Gtfi

VCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQ
.. .. .| .    ..  .... .  || ..      ...
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1550-1740 2.4e-12 41.5 In-house 34-229 (307) alignment 
Range on Protein: 1550-1740
Range on HMM: 34-229/307.0
STTIAKLFPEKNRSLDCLPYDHARV--KLDKQTDDYINAAYMKnLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPQAL
..   .  ..|||  |    |..|.  |.|  . ||| | |.  ..    .||.|| |. ||. .||.|.  ||  .|. |    |      . |||   
tveafsantdknryqdvkcqdkgrivvkfdglasdyihanylg.iaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

DQPTHYDD----YTVTCLKVQQLSHCSEYQ--LKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGvAENALEthrqrckAANAPQSPLIMNCLTGSERSE
 |   . .     .|. | ...|.   ..    .| .  |.    .. || ..|  .|.|   |. | | ||       | .  . |... | .|  || 
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt.ainlle.......avrydtnpvvvhcsaGvGrsG

-LVAI
 .|||
tivai
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1550-1751 4e-12 40.7 In-house 28-234 (285) alignment 
Range on Protein: 1550-1751
Range on HMM: 28-234/285.0
STTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPQALDQ
. |  .  |. ||  |    . .|| | ..  ||| |..|.        .| .| | |.|..||| ||. ||   |. | |      |    |.|. | .
tytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PTHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDlSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERS-ELVAIGVC
  ..  | .|  .... . .      |..    ||  .  |   .      | ||       .    .  |  |  . |. . | .|  |.  .| |  .
vvkfgkyeitlteckeeaiagtilnaltvintedasse.plymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

AIIATQNK
.|   .| 
tirimenp
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1550-1647 5.9e-08 26.7 In-house 51-150 (305) alignment 
Range on Protein: 1550-1647
Range on HMM: 51-150/305.0
STTIAKlfpEKNRSLDCLPYDHARVKLDKQT-DDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALD
|. ||.    |||  |    |.. ||||| .  ||| | |.         ||.|| |  .||..|| |.  .|   .| |    ||       ||| |  
sadiai...tknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

QPT
.  
ekl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1551-1771 3.6e-22 73.6 In-house 27-244 (283) alignment 
Range on Protein: 1551-1771
Range on HMM: 27-244/283.0
TTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMK--NLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPQAld
 . |.  ..|||  . .|.|  ||.|. .. |||||...   .      ..|.||.|  .|. ||| |.. ||  ..| |    |        |||.   
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr..

QPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH-GADAVLDLSLLQLKQWTKGAPAQLLgvaeNAL-ETHRQRCKAANAPQSPLIMNCLTGSERSELVaIGV
    | ..|||  |       .  .| | .   | . | |.  |. .|..  .   .    |.|    . . .  . ...|... | ||  |.    |..
GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaii....nslvkfnkvislqteskkgPivvhCstgiGrtavf.iaa

CAIIATQNKQPIllntIDVWSRICAQRQN
 | .     . .    .|| . .   |..
sasvkdaltesv....vdvfavvkimreq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1551-1746 4.4e-08 27.5 In-house 34-229 (288) alignment 
Range on Protein: 1551-1746
Range on HMM: 34-229/288.0
TTIAKLF---PEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKnlSAGC-PNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPQA
  |.. |   | ..|  .    | .||||.  .| ||.|  .   ||     .| ||.|   ||. .| |. ..  . .| |        |  . |.|  
idiidsfianptrdryenlprcditrvklsddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

LDQPTHYDDYtvtCLKVQQLSHCSEYQLKLSMHGADAVLDL----SLLQLKQWTKGapaqllGVAENALETHRqRCKAANAPQSPLIMNCLTGSERSELV
| . ...  .   |  |..     .  .|.|.     . .       | |..| .       || || |   |  ..  .. | |... . .|. |.  .
lGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWddd......gvPenylsplr.llevlkslqkPivvhssaGvGrtgtl

AIGVCAII
.. . |. 
ililiale
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1552-1772 3.1e-13 43.8 In-house 46-267 (302) alignment 
Range on Protein: 1552-1772
Range on HMM: 46-267/302.0
TIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTI---NDFWSMIWSEKSRTVVCLHTPNEL---FDPYWPQALDQ
.. |  ..||.| |.  .|. .|||... |.|.||. ..  . . .. |.|| |. ..    ..|| |...||  .|| |  ..||   .. ..|.  ..
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgd

PTHYDDYTVTCLKVQQLSHCS-EYQLKLSMHGADAVLDLSLLQLKQWTKGAPAqlLGVAENALETHRQRCKAANAPQSpLIMNCLTGSERSELVAIGVCA
 ..|..  |   ||.. .    .| . .  .|    .  ..  |..| .        .|| . . .    | ..| .. ...    |. |   .   . |
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp..vkyaeliktaakvfakkikaden.tvivSknGaGRagafltlava

IIATQNKQPIllNTIDVWSRICAQRQNS
.   |...    |  ..   | .|| ..
veklqkgkep..nikeivksiRsqRpra
subfamily_PTPN13_pd Subfamily PTPN13 1553-1770 7.6e-24 79.4 In-house 33-249 (273) alignment 
Range on Protein: 1553-1770
Range on HMM: 33-249/273.0
IAKLFPEKNRSLDCLPYDHARVKLDKQTDdYINAAYMKNL-SAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPT
  |   .|||  . ||||..||||....  ||||...|        ..|..| | |.|..||| |.|  |.. .. . .  |      . |||.  ....
kkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

HYDD-YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAEnaleTHRQrCKAANAPQSPLIMNCLTGSERSE-LVAIGVCA
   . ..|. ||||.|.  .  .|...   . .. ... |.. .|   | |.. . . .      ..  .  .  ..|... | .|  ||  |..| |  
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq....fvae.vrrlqtdagPivvhcsaGiGrsGtlitidvvl

IIATQNKqpiLLNTIDVWSRICAQRQ
 .  ..|    ..  ..  ..  |||
glierdk...efdvkeivrklreqrq
0042113 (Phosphotyrosine protein) phosphatases II 1554-1771 7.7e-36 119.1 In-house 6-224 (245) alignment 
Range on Protein: 1554-1771
Range on HMM: 6-224/245.0
AKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQalDQ
 .  ..|||. |.||||| ||||        .||||| |. ...  .|.||..| |.|.|..||| |.|.....|.|.| .. ||    ...|||.  ..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

PTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAanAPQSPLIMNCLTGSERSELVAIgvCAI
.. |.|.|||.|....|...  ..|.....| | ..    ..   |  . .. ||   ...||  |. ...   .. |..  |  |  |. ....  . .
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia..ayl

IATQNKQPILLNTIDVWSRICAQRQN
...| .    ..  ..  ..  || .
mleqlekelgvsleeavkelrsqRpg
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1554-1736 6.8e-13 42.8 In-house 44-227 (439) alignment 
Range on Protein: 1554-1736
Range on HMM: 44-227/439.0
AKLFP-EKNRSLDCLPYDHARVKLD----KQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDpYWPQalDQPTH
|. .   |||  |  ..||.|| |.         |||| |.|        .| .|.|. .| .||| ... .|. |.| |    | .  |||   |. . 
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd.klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.ywps..daevc

YDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT---KGAPAQLLGVaenaLETHRQRCKAA-NAPQSPLIMNCLTGSERSE
| | .| . .  .| .     .|.  .   .  . ..||..  .   |  |||   |    |.  |    |  .    |... | .|  |. 
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv....ldflrainsandkeeygpvvvhcsagvGrtG
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1554-1667 4.8e-11 36.8 In-house 49-162 (310) alignment 
Range on Protein: 1554-1667
Range on HMM: 49-162/310.0
AKLFPEKNRSLDCLPYDHARVKL--DK-QTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDP----YWPQaLDQp
 | .  |||  | .  | .||||  || . .||| | |.|        ||..| |   || ||| ||. |.. ... |    |   |    |||  |   
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnyl.rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgv.

thydDYTVTCLKVQQLSHCSE
      |  |..| .||  ||
....tetygcirvtnlsesse
0037934 (Phosphotyrosine protein) phosphatases II 1555-1745 7e-32 106.3 In-house 8-202 (243) alignment 
Range on Protein: 1555-1745
Range on HMM: 8-202/243.0
KLFPEKNRSLDCLPYDHARVKLDKqtDDYINAAYMKNLsagcPNFIVAQTPQPNTIND----FWSMIWSEKSRTVVCLHTPN----ELFDPYWPqalDQP
.   .|||  |.||||| ||||.   .||||| ... .    |..|. | | |.|..|    || |.|.......|.| ..     |  ..|||   .. 
penlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev

tHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKA-----ANAPQSPLIMNCLTGSERSELVAI
 .|.|.|||.|....|...  . |.|....  | ..    ..   |  . . .      . |.  |. ...     |. ...|..  |  |  |. ....
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

GVCAI
    .
aylml
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1555-1655 4.5e-14 47.0 In-house 31-138 (297) alignment 
Range on Protein: 1555-1655
Range on HMM: 31-138/297.0
KLFPEKNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAGCP-NFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN----ELFDPYWPQALDQPT
.    |||  | | .| .|||| .     ||||| |.       . ..|.|| |  .|..||| ... .  |..| .   .    .   ||||.. ..  
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

HYDDYTVT
.  |. | 
kagdvvve
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1556-1748 5.4e-17 56.3 In-house 44-195 (392) alignment 
Range on Protein: 1556-1748
Range on HMM: 44-195/392.0
LFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFdpywpqaldqpthydd
   .|||  . |||| |||||    |   .||.||.|.... .    .| .|.|.. ...|||.|.. |.  |.. .   .|                  
inlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................

ytvtclkvqqlshcseyqlklsmhGADAVLDLSLLQLKQWTKG-APAQllgvaENALETHRQRCKAANAPQS-PLIMNCLTGSERSELVaIGVCAIIAT
                          | .   .  .. .|     | .      ..|    .  ||     . |||. | .|  |. .| | . ...| 
........................kgddartvaqfhftewPdkdvpkh.....tssllkfikevkadfGqythpliihcsagvgrtgvv.isidsvvah
0049772 (Phosphotyrosine protein) phosphatases II 1557-1770 1.6e-16 56.4 In-house 46-255 (314) alignment 
Range on Protein: 1557-1770
Range on HMM: 46-255/314.0
FPEKNRSLDCLPYDhARVKLDK---QTDDYINAAYMKNLsagcPNFIVAQTPQPNTINDF----------WSMI--WSEKSRTVVC--------------
 ..|||.||.||.|  ||.|..   .. ||||| |...      .||..|.| ..|..||          |.|.  .  ..|..|.              
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LHTPNELFdpywpqaldqpthyD--------DYTvtclkvqqlshcseyqlklsmhgadavldlS----------------------------
       | .. ...              .        ..                               .                            
aAlgKtpllildgng..............neptaadlellk..............................eelydpelferlgikylripvpDgsapll

-LlqlkqwtkgapaqllgvaenaletHRQRCKAANA--PQSPLIMNCLTGSERSE-LVAIGVCAIIATqnkqpilLNTIDVWSRICAQRQ
                           .. ... ..  ...|... |  |  |.  .|... . .          ..  ...... ..| 
ed........................fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRp
subfamily_egg_pd Subfamily egg 1557-1742 1.3e-14 48.6 In-house 40-223 (307) alignment 
Range on Protein: 1557-1742
Range on HMM: 40-223/307.0
FPEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN--ELFDPYWPQALDQPTHY-
. || ||      | .||||. .    .||.| | ..|       .||.||.|  || .||| |.. |. . .| | .    |  . |||.| ...  . 
nlekarskrvhckdssrvklelrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtv

-DDYTVTCLKVQQLSHCSEYQLKLSMHGADavldLSLLQLKQWTKGapAQLLGVAENALETHRQRCKAAnapqSPLIMNCLTGSERSE-LVAIGV
   . ...|||.. .       || . |.|       . |. |      . ..     |.  |.  ...     | ....  |  ..  |||| .
pGslrienlkvdskadplfrvtklklvGgd....deerflehwqgd..vnnssdvysplrvlrklrnls....kpvvvqdilGvskaatlvaiei
subfamily_PTPRK_pd Subfamily PTPRK 1558-1768 1.4e-23 78.2 In-house 44-255 (314) alignment 
Range on Protein: 1558-1768
Range on HMM: 44-255/314.0
PEKNRSLDCLPYDHARVKLDKQTDD----YINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPqalDQPTHY
 ||||| | |.||..||.|    .|    |||||..        .|||.| | ..|..||| ... |.. ..| |    | .      |||   .. ..|
reknrsgdilaydrsrvflitidgdpssdyinaalidsykr.paafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...edtevy

DDYTVTCLKVQQLSHCSEYQLKLSM--HGADAVLDLSLLQLKQWTK-GAPAQllgvAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVaIGVCAII
.|  |...... |.      ....   .| ...  .  .|  .|.. . | .    |.  |.  |.  |  .  . .... |..|. |.    | .. ..
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs....atgllklvrrvkksqeeeaGrivvhCsaGaGrtGtf.iaidivl

ATQNKQpillNTIDVWSRI---CAQ
   ...    ...||.  .   ...
dmiere....gvvdvfnavktlrsr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1558-1771 4e-20 67.0 In-house 29-246 (274) alignment 
Range on Protein: 1558-1771
Range on HMM: 29-246/274.0
PEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD----PYWPQALDQ--P
 .|||  . || ...|| | .     .  .|||| |.|  .     .. .| | |||..||| ||. |... .| |   .|        |.|.| |    
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

THYDDYTvtcLKVQQLSHCSEYQLK-LSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAENALETHRQRcKAANAPQSPLIMNCLTGSERSEL-VAIGVC
 .|.|     .||..  .. .|... |... .    ..      .|  . .| .   . .  ||....| ...||. .| .. |  |  |    .|| ..
erygdve...ikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesr.eeenaklapvvvhCsaGiGrtGcfiaisia

aiiATQNKQpilLNTIDVWSRICAQRQN
     | ..    ...|| . .|  |..
...vrqlre...eivvdvlkivcnlrld
Y_phosphatase Protein-tyrosine phosphatase 1559-1786 1e-44 148.1 Pfam-A 3-233 (235) alignment 
Range on Protein: 1559-1786
Range on HMM: 3-233/235.0
EKNRSLDCLPYDHARVKL--DKQTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDY
.|||. |.||||. ||||  .... ||||| |.|. .    .||..| | ..||.||| |.| ||....|.| . .|     ...|||.. .....|.|.
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTCL-KVQ-QLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAeNALETHRQRCkaaNAPQSPLIMNCLTGSERS-ELVAIGVCAIIA
.|..  |.. . ...  ..|.|. .... .   .. |....|. .|.|..  ..  . ..  ...    .| ..|..  | .|..|.  .||. ..   .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

TQNKQpilLNTIDVWSRICAQRQNSLRDSAILEQSMQIV
.....   ..  ...... .||...  . . ..  ....
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1559-1786 1e-44 148.1 In-house 3-233 (235) alignment 
Range on Protein: 1559-1786
Range on HMM: 3-233/235.0
EKNRSLDCLPYDHARVKL--DKQTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDY
.|||. |.||||. ||||  .... ||||| |.|. .    .||..| | ..||.||| |.| ||....|.| . .|     ...|||.. .....|.|.
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTCL-KVQ-QLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAeNALETHRQRCkaaNAPQSPLIMNCLTGSERS-ELVAIGVCAIIA
.|..  |.. . ...  ..|.|. .... .   .. |....|. .|.|..  ..  . ..  ...    .| ..|..  | .|..|.  .||. ..   .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

TQNKQpilLNTIDVWSRICAQRQNSLRDSAILEQSMQIV
.....   ..  ...... .||...  . . ..  ....
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykai
0045098 (Phosphotyrosine protein) phosphatases II 1559-1740 3.1e-31 104.2 In-house 35-225 (278) alignment 
Range on Protein: 1559-1740
Range on HMM: 35-225/278.0
EKNRSLDCLPYDHARVKldkqtdDYINAAYMKNLsaGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQalDQPTHYDDYTV
.|||  | ||||| |||      ||||| |..    . ..||..| | |.|..||| |.|.......|.| .  ||     ..|||   ...  |.|.||
dknRykdilpydhsrVk......dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftv

TCLKVQQLSHCSEYQLKLSMH----GADAVLDLSLLQLKQWTKGAPAQLL--GVAENALETHRQRCK----------AANAPQSPLIMNCLTGSERSELV
|.|....|..     |..         .  . .  |... |  . .  |       ..||  |...|           .. .. | .  |  |  |.  .
tllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl

AI
..
va
subfamily_PTPN3_pd Subfamily PTPN3 1559-1773 1.2e-26 88.2 In-house 43-258 (280) alignment 
Range on Protein: 1559-1773
Range on HMM: 43-258/280.0
EKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAG---CPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQpTHYDD
.|||  | ||||..||||.... ||||| |..  . .     ..|..| | ..| .||| |.| .||...| | |  |        |||.  |. ..| .
sknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetede.leyge

YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPAqllgVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQN
..|.| | .. . .   .| |. . ..    .  ||  .|.  | |      ... ||  ..  |. .. ..|... | .| .|. .. .   |.  ...
fsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPd....dsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea

KQPIllNTIDVWSRICAQRQNSL
..|.  . .|. ...  ||.. .
aepv..ypldivrtmrdqramlv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1559-1781 1.7e-26 88.0 In-house 11-230 (250) alignment 
Range on Protein: 1559-1781
Range on HMM: 11-230/250.0
EKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL---FDPYWPqaLDQPTHYDD
||||  | ...|..|| | |.      |||||....  .     ||..|.| ..||.||| |.. ||| |.| | . .|    .  |||   .....| |
eknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vekaekyGd

YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAENALETHRQRCKAANapqSPLIMNCLTGSERSELVaIGVCAIIATQN
 ||. |. .. .     .|||| .       .  |.  .|  || |..   | |   . .... .| |   .|.|..| .|  ||    | . |..   .
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn...aPvivqCsaGvgrsGaf.iaidavlerlk

KQpillNTIDVWSRICAQRQNSLRDSAILEQ
|.    ...||.  | . |..  .    |||
ke....kvvdvfkvikvlrkdrphavesleq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1559-1767 2e-22 74.0 In-house 45-250 (515) alignment 
Range on Protein: 1559-1767
Range on HMM: 45-250/515.0
EKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQALDQPTHYD
.|||  . |||| .||||    |.   ||.||.|.. . .    .| .|.|.. ...|||.... |.  |.. .   .|        |||.   .  .. 
kknryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

DYTVTCLKVQQLSHCSEYQLKlsMHGADAVLDLSLLQLKQWT-KGAPAQllgvAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVaIGVCAIIATQ
 . |  . ..  .     .|.  .   | .  .   ....|  ||.| .    .   |   ..     .  . |||. |..|  |  .| | .  ..|  
sikvelvsleactggikrklt..vlkgddsrtvtqfhfteWPdkGvpkh....tssllklikevkadhgqythpliihcsaGvGrtGvv.isidsvvaha

NKQpillNTIDVWSRICA
..     ...||.  .  
ktt....rmvdvfnfvtn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1559-1772 2e-21 71.7 In-house 27-234 (284) alignment 
Range on Protein: 1559-1772
Range on HMM: 27-234/284.0
EKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHtpNELFDPYWPQALDQptHYDDYTV
.|||  . |..|...|||..       |||||....        .| .| |..||..||| |||  .. |.| |   ..    |||.  ..  ... . |
dknrighilafdknvvklerliGeefsdyinasfitGyqr.kdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivi..keerfkv

TCLKVQQLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAenALETHRQRCKAANAPQSPLIMNCLTGSERSElVAIGVCAIIATQNKQ
    |.. .     ...|| .|    . ..    .. |  .| | .   .   .|  . .  .  .  ...... | .|. |.  | | . ...   ...
kvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlm..rlvkkvrhltskenhranivvhcsagvgrtg.vyivldvlldrmkee

pillNTIDVWSRICAQRQNS
    . .||.  .   ||. 
....kqvdvynfvrdlrqqr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1559-1783 2.4e-20 67.7 In-house 51-269 (315) alignment 
Range on Protein: 1559-1783
Range on HMM: 51-269/315.0
EKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPqalDQPTHYD
.|||  . ..||..||.|     ..  ||.||....  .     .| ||.|......||| ... |.  ..| |       ..  . |||   |.   | 
qknryiniiaydksrvqlpllendphsdyvnanfidGynk.krryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...dkkviyG

DYTVTCLKVQQLSHCSEYQLklSMHGADAVLDLSLLQLKQWTkgaPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELvAIGVCAIIATQN
 .|||  . .. .. .   |  |.   | . ..  |..  |     ...   . . .. .|.  .  ..  ..... |  |  |.    | . |..   .
kitvtrkseevnteytvrtl..svvfgdnirevvqlhytswp...dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGt.fitldavldqae

KQpillNTIDVWSRICAQRQNSLRDSAILEQSM
 .    | |||.  |   |||  .  ...||  
ae....naidvynfitgvrqnrikmvqvaeqyq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1559-1771 2.7e-18 61.2 In-house 50-266 (325) alignment 
Range on Protein: 1559-1771
Range on HMM: 50-266/325.0
EKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC---LHTPNELFDPYWPQALDQPTHYDD
.|||  . ...|..|| |  .      |||||.|...   .   |. ||.|...||||.| ..   ..  ||    | . ..    |||. . .  ..  
aknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGg

YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT----KGAPAQLLGVAEnALETHRQRCKAANAPQSPLIMNCLTGSERSelvaiGVCAIIA
  |    ....|     .|..        . .  .||. |     .  || |. . .  ...  .| .|     .|... | .|  |.     || . . 
levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq.lvkavservtantkastpilvhcsaGvGrt.....Gvfisly

TQNKQPILLNTIDVWSRICAQRQN
.  .. |    .|..  .   |..
salakvieesrvdifgfvkklrkd
subfamily_CG42327_pd Subfamily CG42327 1559-1658 1.4e-13 45.2 In-house 30-138 (319) alignment 
Range on Protein: 1559-1658
Range on HMM: 30-138/319.0
EKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQ--ALDQPTH
.|.| .. .|  ..|| |..    . | |..|.|..        .| ||..  ..  ||| ..|  .||..|.|  . ||       |.|   .||.   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YDDYTVTcLK
| |. || ||
yGdilvt.lk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1559-1654 2.9e-13 44.3 In-house 49-160 (350) alignment 
Range on Protein: 1559-1654
Range on HMM: 49-160/350.0
EKNRSLDCLPYDHARVKLD------------KQTDDYINAAYMKNL---SAGCPNF--IVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDP
 |||  . |||.|.||||              .|.||||| |.|         |.|  | .|.| |.|..||. .|   | . .. | .  ||    .. 
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPQaldqpTHYDDYTV
||..       |||.||
YWqe.....gsydditv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1559-1760 6.6e-13 43.0 In-house 58-256 (290) alignment 
Range on Protein: 1559-1760
Range on HMM: 58-256/290.0
EKNRSLDCLPYDHARVKLD-KQTDDYINAAYMKNLSagcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLH----TPNELFDPYWPQALDQPTHYDDYT
.|||  |    | .|| |.  .  ||. | |.| |    . ||..| .  .|. |.| |.  ||  ..| |       .   ..|.|.   .   . ..|
kknrykdvvcndktrvilkdGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

VTCLKVQQLShCSEYQLKLSMHGADAVLDLSLLQLKqwTKGAPAQLLGVAENALetHRQRCKAANApQSPLIMNCLTGSERS-ELVAIGVCAIIATQNKQ
|.| . ..       .  ||.   |.  .  |  ||  .|  | . .  .. ||   |      .|   |... | .|  |.  .||| |.. | .. |.
vlcseeddkd.aniikktlsvrdkdsGkehklkhlk..ikswpdksvalstlal..lrtlrilrka.sGpvvvhcsaGiGrtGtfvaievglqilldGke

PILLNTID
  ||... 
ldlldlvr
0041856 (Phosphotyrosine protein) phosphatases II 1559-1653 8.3e-13 43.8 In-house 3-76 (182) alignment 
Range on Protein: 1559-1653
Range on HMM: 3-76/182.0
EKNRSLDCLPYDHARvkldkqTDDYINAAYMKnLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHtpnelFDPYWPQALdqpthyddyT
.|||  | ||||| |        ||||| ..   |    .||..|.| ..|..||. |..... .|.|.|       ..|||. |         .
dknrysdilpydhsr......dldyInanlyl.gslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywpell.........e
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1559-1775 1.2e-11 39.2 In-house 10-223 (239) alignment 
Range on Protein: 1559-1775
Range on HMM: 10-223/239.0
EKNRSLDCLPYDHARVKLDKQTD----DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPqalDQPTHYD
 |||  . . |||.|| |.| ..    |||||.|...       .| .|     .  ||| |.| |.   .| |    |        |||   |  ..| 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskyc

DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAqllgVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIgVCAIIATQ
.  ||  | . ..      . .|  |      .   ..  |  || |      |   |  .|.  | .     | .. | .|  |.  . . . |..   
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq....yatavlglrrkitkdslpgarpwvihcsagvgrtgaflv.idamlrqa

NKQpillNTIDVWSRICAQRQNSLRD
.||    .|.|..  . | |..  . 
kkq....ktvdifnyvkairedrphm
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1559-1777 1.3e-11 39.1 In-house 9-224 (239) alignment 
Range on Protein: 1559-1777
Range on HMM: 9-224/239.0
EKNRSLDCLPYDHARVKLDKQTD----DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPqalDQPTHYD
 |||  . . |||.|| |.| ..    |||||.|...       .| .|     .  ||| |.| |.   .| |    |        |||   |  ..| 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskyc

DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAqllgVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIgVCAIIATQ
.  ||  | . ..      . .|  |      .   ..  |  || |      |   |  .|.  | .     | .. | .|  |.  . . . |..   
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq....yatavlglrrkitkdslpgarpwvihcsagvgrtgaflv.idamlrqa

NKQpillNTIDVWSRICAQRQNSLRDSA
.||    .|.|..  . | |..  .   
kkq....ktvdifnyvkairedrphmvq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1559-1692 1.3e-10 35.4 In-house 98-231 (244) alignment 
Range on Protein: 1559-1692
Range on HMM: 98-231/244.0
EKNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNElFDPYWPQALDQPTHYDDYTVTC
 |||    ||.|  || | |    . ||||...  |     ..|..| |  .|  ||| |.   .   .| | . .|  | |||..     . .| ||| 
wknregaglpfdfnrvplskgsmgntyinasfvgclgr.taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.edeywpdseplewyeeditvtl

LKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT
   ...      .|..     ..   |...|. .| 
tdrdefknikasnleiesdmneshqaltmfqisnwp
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1559-1634 1.3e-08 28.8 In-house 49-120 (303) alignment 
Range on Protein: 1559-1634
Range on HMM: 49-120/303.0
EKNRSLDCLPYDHARVKLDKqtDDYINAAYMKnLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL
.|||  | .  ||..|||      || |.|.. | .   . |..| | . |  ||| ||  .| . |. | | .| 
dknrfvdvicldhskvklsd..ssyihasyle.lds.skkailtqlplshtaadfwqmiieqkvkcvlllltdsey
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1559-1634 1.3e-08 28.5 In-house 50-144 (349) alignment 
Range on Protein: 1559-1634
Range on HMM: 50-144/349.0
EKNRSLDCLPYDHARVKLDK------------------QTDDYINAAYMKNLSAGC-PNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL
 |||  | |||.|.|||| |                  . |||||| |.|         .|  | | | |..||. .|  .. . |. |   .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1559-1628 8.5e-08 26.3 In-house 50-119 (305) alignment 
Range on Protein: 1559-1628
Range on HMM: 50-119/305.0
EKNRSLDCLPYDHARVKLDKQ-TDDYINAAYMKNlSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCL
.|||  |    |. ||||.     .|| | |.    .    || .|.|  .|  ||| | . .|  ..  |
gknrykdvgcldnnrvklegpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifml
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1560-1740 1.4e-19 65.3 In-house 6-191 (237) alignment 
Range on Protein: 1560-1740
Range on HMM: 6-191/237.0
KNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHT---PNEL-FDPYWPQAlDQPTHYDDYT
|||  .   |||.|| |     . |||||.|.|..     ..| || |  .. .||| |.| ||   .| |      |||    |||.. |||. |  .|
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvlt

VTCLKVQQLSHCSEYQLKLSMHGADAvlDLSLLQLKQWTKgAPAQllGVAENALETHRQRCKAANA-----PQSPLIMNCLTGSERSELVAI
|.  | ...|  .   | ||...     .. |..  |.|   | .  || ...    | | .  |        .| |. | .|  |. .. .
vslkkkeefsdytvrslllskrltlk..evrlihqyqfts.wpdr..gvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1560-1739 2.4e-09 31.3 In-house 40-219 (281) alignment 
Range on Protein: 1560-1739
Range on HMM: 40-219/281.0
KNRSL--DCLPYDHARVKL---DKQTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCL----HTPNELFDPYWPQALDQPTHYD
||| |   ||   . ..|.   .|.. ||| | |..        .|..| |. .|  ||| ||| |.. ..| |     |  |    |.|.      ..|
knrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfd

DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLlqLKQWTKgapAQLLGVAENALETHRQrCKAAnapQSPLIMNCLTGSERSEL-VA
 ..|.             .|.||  |   ..   |   |.|      |. . .|  |.  |.  .|     .| .. | .|  ||   .|
klsvsyedstvnkslvttrlnlsyegetrlithwl..wkewpd...wqvpessevmlkilrk.irar...stppvihcsagvgrsgtlma
0044763 (Phosphotyrosine protein) phosphatases II 1568-1683 3.8e-07 25.4 In-house 1-76 (178) alignment 
Range on Protein: 1568-1683
Range on HMM: 1-76/178.0
PYDHARVKLDKQTD----DYINAAYMKnlsagcPNFIVAQTPQpntiNDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQALDqpthyddytvtclkv
|.|. ||.|..  .    ||||| ..       |...... |.     |.. ... .. ...|.| .. ||.    |||||.  .               
pldrtrvllsnleglersdyinaseil......pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............

qqlshcseyqlklsmhgadavldL
                       .
.......................i
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1570-1632 4.3e-08 27.1 In-house 59-120 (347) alignment 
Range on Protein: 1570-1632
Range on HMM: 59-120/347.0
DHARVKLDKQTDDYINAAYMKNlSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN
....     ... ||||...|       ..|..| | |.|. ||| |.   |   || .  | 
eksknsraddvetyinashikf.dnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1579-1787 1.9e-07 25.6 In-house 44-256 (290) alignment 
Range on Protein: 1579-1787
Range on HMM: 44-256/290.0
QTDDYINAAYMKnLSAGCpNFIVAQTPQPNT-------INDFWSMIWSEKSRTVVCLHTPNE------LF--DPYWPQALDQPTHYDDYTVTCLKVQQLS
 .|||| | ...  . |  ..|. |.|| ..       |..|| |.  ||.. || |   .|      ||    | |.. ..   ... || | .  .  
fnddyiHAnrvt.cpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeked

HCSEYQLKLSMHGaDAVLDLSLLQLKQWTKgapaqlLGVAENALeTHRQRCKAANAPQSPLIMNCLTGSERSE---LVAIGVCAIIATQNKQpillNTID
   . .| .   . .  . .   .||.|.|      | | |. . |  .  .  .| ..| |. |  |  ||     . .|   |. |....    .. |
dvetRelvvkfdd.eeeftvtHsllkgWnk......lnvqedtk.tllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv....kled

VWSRICAQRQNSLRDSAILEQSMQIVL
| . .  ||.. . .   |   .  ..
vlkalrkqralaitsalelafvdagiv
0051429 (Phosphotyrosine protein) phosphatases II 1580-1785 8.1e-14 47.4 In-house 3-220 (272) alignment 
Range on Protein: 1580-1785
Range on HMM: 3-220/272.0
TDDYINAAYMKNLsaGC---PN-FIVAQTPQPNTINDFWSMiWSEKSRTVVCLHTPNELF----DPYWP----------QALDQPTHYDDYTVTCLKVQQ
...|||| ... .  |    |. .. .. | |.|..||| . .... .|.|.| ...|.     |.|||             ...  | ...||.|....
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LSHCSEYQLKLSMH-GADAVLDLSLLQLKQWTKGAPAQ--LLGVAENALEthrqrckaanapQSPLIMNCLTGSERSELVAIGVCAIiaTQNKQPILLN-
|...  . | |... .|.... . .|.  .|     .|  || . |  |.            . |... |  |  |. .|.  .  .   .      .. 
lldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld............ggpvlvHCsaGkdRTGtvvalllll..lgvsletivdd

-------TIDVWSRICAQRQNSLRDSAILEQSMQI
         ...... ||| ..  . . ... ...
Ylltnlyleeaveelraqrpgavqteeqylflyea
0043147 (Phosphotyrosine protein) phosphatases II 1580-1648 2.8e-09 32.5 In-house 4-55 (172) alignment 
Range on Protein: 1580-1648
Range on HMM: 4-55/172.0
TDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPnelfdpywpqaldqptH
 .||||| |. .|.   ..||. | | .||..||| |..... ...|.| .                  
gsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel................l
0036282 (Phosphotyrosine protein) phosphatases II 1581-1658 1.5e-07 26.8 In-house 2-61 (174) alignment 
Range on Protein: 1581-1658
Range on HMM: 2-61/174.0
DDYINAAYMkNLSAGCPNFIVAQTPQPntindFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQaldqpthyddytvtclK
.||||| .. .||   |..|. | | .     || |.......|||.| ...||    .  |||                 .
sdyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................l
0051082 (Phosphotyrosine protein) phosphatases II 1581-1745 1e-06 23.9 In-house 3-116 (151) alignment 
Range on Protein: 1581-1745
Range on HMM: 3-116/151.0
DDYINAAYMKNLsagcpnFIVAQTPQPntinDFWSMIWSEKSRTVVCLHTPNELFdpYWPQALDQPThyddytvtclkvqqlshcseyqlklsmhgadav
.||||. |. .       ... . | .    ||. ...... .|.|.| .. |    |.|. | .                                   
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

LDLSLLQLKQWTKGAPAQLLGVAENALETHRQrckaanAPQSPLIMNCLTGSERSELVAIGVCAI
...  ...  |.     ...  . ..||  ..       .. |... |  |  |. .... .. .
ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml
0046846 (Phosphotyrosine protein) phosphatases II 1582-1740 3.3e-08 29.0 In-house 13-128 (176) alignment 
Range on Protein: 1582-1740
Range on HMM: 13-128/176.0
DYINAAYMKNlsagcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQALDQPThyddytvtclkvqqlshcseyqlklsmhga
||||| ..       . .|. | | |.|. ||. |..... ..||.| .. ||     . |||.  .                                 
dyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

davldlsLLQLKQWTKGAPAQLlGVAENALETHRQRCKAAnapqSPLIMNCLTGSERSELVAI
         .   |  . . .|    ...||  |.. |.      | .  |  |  |. ....
.......qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1582-1692 4.6e-06 20.6 In-house 76-189 (301) alignment 
Range on Protein: 1582-1692
Range on HMM: 76-189/301.0
DYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGA
  | | ...        ||..|.| .|| .||| |.   .  ..| |       .|  . | |.   .  . . ....  . ... . . .. .| .. .
vPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleveds

DAVLDLSLLQLKQWT
   ..   .   |..
tgkfatrtvthyqys
0049260 (Phosphotyrosine protein) phosphatases II 1598-1740 9.2e-07 24.2 In-house 10-108 (152) alignment 
Range on Protein: 1598-1740
Range on HMM: 10-108/152.0
NFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDPYWPQALdqpthyddytvtclkvqqlshcseyqlklsmhgadavldlsLLQLKQWTKGAPA
 || .| | |||..||| |... . .|.|.| .. ||  ....|                                             .  .|  . . 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwpDhgvp

QLLGVAENALETHRQRckaANAPQSPLIMNCLTGSERSELVAI
.|  . . .|. ....   |  .. | .  |  |  |. ....
dlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlva