Gene Ptpmeg in Drosophila melanogaster

Synonym: CG1228, Dmel\CG1228, MEG1, Meg, PTP-meg, anon-WO0118547.211, dMEG1, dPtpmeg, ptmpeg, ptpmeg, scc, Dmel_CG1228, Ptpmeg

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP043_AA protein Get Run
DmelP043_AA_629-960 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 38-121 1.6e-20 63.2 Pfam-A 1-80 (80) alignment 
Range on Protein: 38-121
Range on HMM: 1-80/80.0
VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSvsldNDAVPLLEFRVKFFV
| .||. .... ......|..||..|.. |.|.| .|||| | ..  .  .|.|..|. ..|...    ...  .| .||||.|
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgve....egkpttlllrvkfyv
FERM_M FERM central domain 123-232 2.5e-21 66.3 Pfam-A 1-126 (126) alignment 
Range on Protein: 123-232
Range on HMM: 1-126/126.0
DPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFN-ALEHQPGY-LSGMQL------LC--------DQTTEAERKVGELHKLHR
||.....| .....|.|.|...|...|.|. ..  |||.. .| |.||.. . ... .. .. ..       |          .. . |... | || ..
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GQLPADAEYNYLEHAKRLELYGIDLH
|. .|.|...||. |..|. ||..|.
glslaeaklkylqaaqslpdyGvslF
FERM_C FERM C-terminal PH-like domain 236-324 9.3e-26 80.2 Pfam-A 1-88 (90) alignment 
Range on Protein: 236-324
Range on HMM: 1-88/90.0
DSNGKELQLGVSAVGLLVFQHSLRV--NTFSWSKMVKVSFKRKDFFIQLRRepsENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPH
...|..| |||.| |||....  ..  ..|.||.. |.|||.| |.|.||    |.....| | .|... .| |.|.|.|.|..|| .|..
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrrkv
FA FERM adjacent (FA) 327-371 6.1e-20 59.8 Pfam-A 1-43 (47) alignment 
Range on Protein: 327-371
Range on HMM: 1-43/47.0
SRFLniSLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLL
|.|.  |||||| ||||||.|...||...|| .. | |||||| |
skff..slGSkFRYSGRTekQvieesreigrkppsfeRspskryl
PDZ PDZ domain (Also known as DHR or GLGF) 505-588 5.5e-19 58.3 Pfam-A 2-80 (81) alignment 
Range on Protein: 505-588
Range on HMM: 2-80/81.0
IRLQADEQGRYGFNVKGGVDLS-LPVQVSKVVPHtPADRCTPrVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHqasgELLLTV
..|.....|. ||..||| | .  .. ||.|||  .|. . . ..||| .| .||.|| ...|...|..|....     |. ||.
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg....evtLti
subfamily_PTPN3_pd Subfamily PTPN3 627-962 8.5e-143 469.3 In-house 2-278 (280) alignment 
Range on Protein: 627-962
Range on HMM: 2-278/280.0
TQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTgDYINANYVNMEIPG-GAVNRYIATQGPLASTTTDF
..|||||..||.|||.|||.| .|||.|.|||..||||.|..|||||||.|||.|||.|..| | |||||||||||||. |.||||||||||||.|.|||
resllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdf

WRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAeGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFT
|.||....|.|.|||||..|.||.||||||| |..||... .|||.| .|  ||| |.|.||.|||||.  |.|.|...||||||||.||.|.. ||||.
WqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv

ERVRAARnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEARE
||||..|                                                          |... ||.|||||||||||||||..|||||.||.|
ervrklr..........................................................sgkeePvvvhCsaGigrtGvlilletalalieaae

PVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKI
||||||||||||||||..||..|||.||||.|...|..|
pvypldivrtmrdqramlvqtasqykfvCeailkvyeei
0050432 (Phosphotyrosine protein) phosphatases II 630-961 6.9e-86 283.7 In-house 32-301 (308) alignment 
Range on Protein: 630-961
Range on HMM: 32-301/308.0
LLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLvnSLTGDYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMV
| || . | .| | ...| .... |.| .. |..|.| .||||.|| ||| .|| |  . . |||||.||.. .  .  ...||||||| .|. ||||||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys.sklprkfIatqgPlpntvedFwrmv

QQESSHLLVMLTTVMESGRQKCHQYWPVTGE-ELQLAEGFSVRCLSEKPdeTGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
 .. ... ||||. .| ||.||.|||| . . . .  ..|.|..|||.    .... |.. |..  . | |...|..|..||||.||..|. .|.| |.|
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RaarnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhQCIsaANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVY
|                                                          ...   ..|..||||||.||||..|..|..| ..|.   | 
r..........................................................ksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvd

PLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
....|...| ||..|||...||.|......  ...
vfeavkklReqRpgmvqtpeqylflyralleylkl
0047943 (Phosphotyrosine protein) phosphatases II 632-956 5.2e-81 267.4 In-house 4-269 (273) alignment 
Range on Protein: 632-956
Range on HMM: 4-269/273.0
LLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLvNSLTGDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQ
|| . | .. ||...||...  |.| .. |..|.|  ||||.|| ||| .|| | .. . |||||.||..       ...||||||| .|. |||||| .
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdg...ynlkrkfiatqgPlpntvedfwrmvwe

ESSHLLVMLTTVMESGRQKCHQYWPVTGEE-LQLAEGFSVRCLSEKPdeTGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
. ....||||...| ||.||.|||| .|.|  .  . |.|..|||.    .... |.. |..   .| |...|..|. ||||.||.... .||| | || 
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

ARNrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL
|..                                                         .  |.||.||||||.||||..|..|..| ..|..  | .|
ale........................................................alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvl

DIVRTMRDQRACMVQNVSQYRFVCECIC
..|. .|.|| .|||...||||..|...
eavkllrsqRpgmvqtpeqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 633-961 2.1e-82 272.0 In-house 6-279 (297) alignment 
Range on Protein: 633-961
Range on HMM: 6-279/297.0
LSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLvNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQE
| . | .  || ..| ...  ..  .. |..|.| .||||.|| ||| ||| | ..   |||||.||..    .  ...||||||| .|. |||||| ..
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgy...dlkrkfIatqgPlpntvedFWrmvweq

SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
 .. .||||...| ||.||.|||| . .| .  ..|.|..||.. .. .... |.. ..|  . |.|...|..|. ||||.||..|. .|.| |.|| ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

NRTllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisAANPPVIVHCSAGIGRTGVLILMDTALALME---AREPVYP
. .                                                          ..||.||||||.||.|..|..|..| ..|    .. | .
kll........................................................psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdi

LDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
|..|...|.||...||...||||..|..   ..|
leavkklReqRpgavqtleqyrflyeallellkk
subfamily_PTPN14_pd Subfamily PTPN14 633-833 5.4e-45 148.7 In-house 16-219 (300) alignment 
Range on Protein: 633-833
Range on HMM: 16-219/300.0
LSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL--TGDYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMVQ
|   | .| . ..|| . .|. |  .. |. | ||.|||..|. ||. .|| |. .   . .||||  ... . ||.   ||..||||  | .|||.|| 
lekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv.ggkersyivaqgPleltvqdfWqmvW

QESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
..  .|.||||   |.|..|...|.| .... . .|    .  ..  ....|.. . . ||    .|.| ..|.||  |||| ||.|.. ||.. |.|..
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

ARNRT
 |..|
vrrkt
0039614 (Phosphotyrosine protein) phosphatases II 636-958 2e-79 262.4 In-house 28-288 (297) alignment 
Range on Protein: 636-958
Range on HMM: 28-288/297.0
GLASGALLAQYELMYRKNPDlaITEARKPANAPKNRYRDISPYDCTRVSLVNS----LTGDYINANYVnmEIPGGAVNRYIATQGPLASTTTDFWRMVQQ
 . .. ||...| ... .||  ...|..|.| .||||.|| ||| .|| |       |  |||||.||  . .    ...||||||| .|. ||||||..
ansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedFwrmvwe

ESSHLLVMLTTVMESGRqKCHQYWPVTGEelqLAEGFSVRCLSEKPdeTGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
. .. .||||. .| || ||.|||| .|.     ..|.|..|...    . .. |.. .... | |...|.||. ||||.||....|.||| | || |..
qgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

RtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIV
.                                                        .  . ||.||||||.||||..|.....| ..| .  | .|..|
e........................................................lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleav

RTMRDQRACMVQNVSQYRFVCECICAA
...| || ..||. |||||......  
kelreqRpgavqtpsqyrflydallel
0040438 (Phosphotyrosine protein) phosphatases II 640-961 2.1e-80 265.6 In-house 18-278 (317) alignment 
Range on Protein: 640-961
Range on HMM: 18-278/317.0
GALLAQYELMYRKNPDlAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT---GDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQESSHL
.||| ..| ... ..|  ...|..|.| .||||.|| ||| .|| | .       |||||.||..       ...||||||| .|. ||||||... ...
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdg...pnlkrkfIatqgPlpntvedFwrmvweqgvtv

LVMLTTVMESGRQKCHQYWPVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtl
.||||. .| ||.||.||||   .| .  ..|.|..|||.    .... |.. ..|  . |.|...|..|..||||.||..|.|.|.| |.||.|.    
ivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal....

lqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTM
                                                      .  . ||.||||||.||||..|.....| ..| .. | . ..|...
......................................................edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

RDQRACMVQNVSQYRFVCECICAAYMK
| ||...||. .||||......  ...
reqRpgavqtpeqyrflydalleylkr
0043336 (Phosphotyrosine protein) phosphatases II 640-956 2.7e-76 252.0 In-house 20-274 (278) alignment 
Range on Protein: 640-956
Range on HMM: 20-274/278.0
GALLAQYELMYRKNPdLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQESSHL
 .||...| ... ..   .. |..|.| .||||.|| ||| .|| | .    |  |||||.||..       ...||||||| .|. ||||||... .. 
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg...ynvprkfiatqgPlpetvedFwrmvwelgvtt

LVMLTTVMESGRQKCHQYWPvtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtl
.||||. .| ||.||.||||   .. .  ..|.|..|.|.    . .. | . ..   ..| |...|..||.||||.||....|.|.| ..|| |.    
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal....

lqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTM
                                                      .  | ||.||||||.||||..|.....| ..| .  | ....|...
......................................................edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RDQRACMVQNVSQYRFVCECIC
| ||...||. |||||..|...
reqRpgavqtpsqyrflyeall
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 640-760 1.7e-22 74.4 In-house 27-145 (310) alignment 
Range on Protein: 640-760
Range on HMM: 27-145/310.0
GALLAQYELMYRKNpDLAITEARKPANAPKNRYRDISPYDCTRVSLV--NSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLL
  |  ||  .  |. | ..|      .  |||| |.   | .|| |   .|  .||| ||||. .      . .| .||||  |  |||||. || .  .
eglvkqyrkldakq.dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny...lrstficsqgplqhtiidfwrmifqeraesi

VMLTTVMESGRQKCHQYWPVTGE
..|  |.| || ||  |||  | 
lllckvgeegrpkcvgywpslgv
0051299 (Phosphotyrosine protein) phosphatases II 641-958 1.8e-82 272.3 In-house 24-285 (288) alignment 
Range on Protein: 641-958
Range on HMM: 24-285/288.0
ALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQESSHLL
 ||...| .....||| .. |..|.| .||||.|| ||| .|| | .     ..|||||.|...       ...||||||| .|. |||||| .. ... 
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg...ynlkrkfIatqgPlpntvedFWrmvweqnvrvI

VMLTTVMESGRQKCHQYWPVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK------DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRaarn
||||...| ||.||.||||   .. .  . ..|..|||.    .... |.. ..       ..| |...|..|..||||.||..|.|.|.| ..||    
vmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr....

rtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIV
                                                      ..... ..||.||||||.||||..|..|..| ..|... | .|..|
......................................................kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

RTMRDQRACMVQNVSQYRFVCECICAA
...| || .|||...|||||.|... .
krlreqRpgmvqtpeqyrfvyealley
0045450 (Phosphotyrosine protein) phosphatases II 641-957 7.4e-78 257.7 In-house 28-302 (307) alignment 
Range on Protein: 641-957
Range on HMM: 28-302/307.0
ALLAQYELMYRKNP--DLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT----GDYINANYVNMEIP-----GGAVNRYIATQGPLASTTTDFWRMV
 ||...| ... ..     ...|..|.| .||||.|| ||| ||| | .       .|||||.||.. ..         ...||||||| .|  |||||.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

QQESSHLLVMLTTVMESGRQKCHQYWPVTgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK---DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
... ....||||. .| ||.||.|||| . .| .  . | |..|||.    .... | . ..    ..| |...|..|..||||.||.... .|.| |.|
weqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RAARNRtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREP--
|.|...                                                        .  . ||.||||||.||||..|.....| ..|...   
rkalee........................................................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtll

-VYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 | .|..|...|.|| ..||| .||||..|... 
dvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 641-832 7.5e-36 118.8 In-house 23-213 (305) alignment 
Range on Protein: 641-832
Range on HMM: 23-213/305.0
ALLAQYELMYRKNPDLAITeaRKPANAPKNRYRDISPYDCTRVSLVNSLTG---DYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLL
.| |||...|...  . ..  .| ||. |||...| ..|  |. | .. .    |||||.||.        ..||..|||| .| .||||.. .|  . .
gleaqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy...krkkkyivaqgPlkntvadfWrliveekvsti

VMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKpdETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
|||| ..| |..||.|||| .  | .  . |||   |||  ..  .. |.. .     ..|.| . ..|   |||| ||  .  .|.. .||. ....
vmltklveggkdkCrqYWpesktekkefgefsvelksek..tasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 641-828 3.6e-30 100.0 In-house 17-207 (307) alignment 
Range on Protein: 641-828
Range on HMM: 17-207/307.0
ALLAQYELMYRKNPDLAITEARKpANAPKNRYRDISPYDCTRVSL-VNSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
||  ... . .|.|.   .|| . ||. ||||.|.   | .|. . .. |. ||| |||. . |     ...|..|||| .|  .|| |. ||    ..|
alvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkfdglasdyihanylgiai...kpkkficaqgplentqysfwamaiqekvesvim

LTTVMESGRQKCHQYWPVT-GEELQLAE---GFSVRCLSEK---PDETGSFVfREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
|  |.| .. ||.||||.  |..|  .|     ||  |  |   |||    |  .. ..  .. | |.|.|.  |||. ||      ... | || 
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry
0046845 (Phosphotyrosine protein) phosphatases II 642-961 2.2e-80 265.4 In-house 2-276 (284) alignment 
Range on Protein: 642-961
Range on HMM: 2-276/284.0
LLAQYELMYRKNPDL--AITEARKPANAPKNRYRDISPYDCTRVSLVNSLT----GDYINANYVNMEIPG--GAVNRYIATQGPLASTTTDFWRMVQQES
| ...| ... ...|   .. |..|.|  ||||.|| ||| .|| | .       .|||||.||..   .     ...||||||| .|. |||||| .. 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SHLLVMLTTVMESGRQKCHQYWPVTgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
....||||. .| ||.||.|||| . .| .  ..|.|..|||.    .... |.. |..   . | |...|..|..||||.||..|. .||| . || ..
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

NRTLLQeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaanPPVIVHCSAGIGRTGVLILMDTALALMEARE---PVYP
...  .                                                        .|..||||||.||||..|..|..| ..|...    | .
enlpgg........................................................gpivVHCsaGvgRtGtfialdllleqlekeglllgvdv

LDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
|..|. .|.|| .|||...|||||.|... ....
leavkrlreqRpgmvqtleqyrfvyealleylkl
0045098 (Phosphotyrosine protein) phosphatases II 642-959 5.5e-75 247.6 In-house 9-272 (278) alignment 
Range on Protein: 642-959
Range on HMM: 9-272/278.0
LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSlvnsltgDYINANYVNMEiPggavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLT
|| ..|  .. ..   ||.| .. |..||||.|| ||| .||        |||||.|...  |    ...||||||| ||. |||||.... .. .||||
lllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy.p....kkfIatqgPlpstvadfwrmlwelgitvivmlt

TVMESGRQKCHQYWPvTgEELQLAEGFSVRCLSEKPDetGSFVFREFVLK------DKHEQRHIHHMQYLAWPDHCVPSDP--NLFLEFTERVRAARNRT
...| ||.||.||||   .. .  ..|.|..|||.    . .. | . .          |.|...|..|| ||||.|||.|  . |||..|..|.|... 
elvelgrekcaqywp.e.ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

LLQEIEESlkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqCISAANPPVIVHCSAGIGRTGVLILMDTALALMeaREPVYPLDIVRT
. . . .                                               .   . ||.||||||.||||.|..... | |.   . | .|..|..
aslllssl.............................................llldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavke

MRDQRAC-MVQNVSQYRFVCECICAAY
.| || . .||| .||||..|...  .
lrsqRpglavqnleqyrflyefllell
subfamily_PTPN9_pd Subfamily PTPN9 642-832 1.7e-43 143.7 In-house 18-208 (297) alignment 
Range on Protein: 642-832
Range on HMM: 18-208/297.0
LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLV
|  .|. . ....   .. ....||  |||| |.  || ||| | .     . ||||||.|.        . .|||||||  |..|||||| ...   .|
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy...kqkkafiatqGplkktvsdfWrmvWeqevlviv

MLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKpdETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
| | |.| || || |||| . |. .    .||. .. .  |.  ...| ...|  ...|.|.. | |.|.|||. |||. . .|.. | || ..  
mttrvvergrlkcgqyWpleeessaefgdlsvsnveve..eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 642-824 2e-42 140.1 In-house 9-191 (297) alignment 
Range on Protein: 642-824
Range on HMM: 9-191/297.0
LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTG-DYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
| |...|.....   . . |....   |||||||  .| ||| | .. |. |||||.|| .     |  .|| .|||| .|  |||..| ..    .||.
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpd.eeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE
. . | ||.||  ||| . .| . |  . |  ||.  ||    .. |. |  . |.|...|.|.|.|||| |||| .    |  
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_PTPRG_pd Subfamily PTPRG 642-832 1.3e-38 127.6 In-house 21-218 (563) alignment 
Range on Protein: 642-832
Range on HMM: 21-218/563.0
LLAQYE-LMYRKN-PDLAITEARKPANAPKNRYRDISPYDCTRVSLVnSLTG-----DYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESS
. ...| |. . .  || .. ..|| |  |||| .| .|| .||.|  .|.|     |||||||..        . .|||||||..|. |||||. .. .
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvkls.plpgkkkklDYinAnyidGy...qkskafiatqgplkdtfddFWrmiWeqnv

HLLVMLTTVMESGRQKCHQYWPVtgEELQLAEGFSVRCLSEKPDET---GSFVFREFVLKDKHE---QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
...||.| . |.||.||..|||   .| .  . ..|.  .|.   .    ..| ... ||.|..   .... . .|  ||||.||. .   | | ..  |
aiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa

ARNR
|...
anka
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 642-822 1.2e-23 78.3 In-house 17-213 (301) alignment 
Range on Protein: 642-822
Range on HMM: 17-213/301.0
LLAQYELMYRKNPDLAITEArKPANAPKNRYRDISPYDCTRVSLVNSLT-----GDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHL
. .||. ....... .. .  . .|.. ||...|..||  |. | .  .      .||||.|..        ...||.|||. .| .||||.. ||    
feeqykelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy...sekkkfiaaqgpmkktlvdfWrliwqekpvs

LVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEK--PD------------ETG-SFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLE
.||.|   |. ..||.|||| . .| .    |.|   .|.  ||             .. ... |.|  | ... ...  .|   ||.. |  .|.  |.
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

F
 
v
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 643-830 1.9e-43 143.7 In-house 23-208 (318) alignment 
Range on Protein: 643-830
Range on HMM: 23-208/318.0
LAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
 ..|| . |..   . ... .|.|. |||| .| .|| ||| |    .. . |||||||..      . . |||.|.||. | .|||||| .  | ..||
seeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr...rkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTTVMESGRQKCHQYWPVTGEelQLAEGFSVRCLSEKpdETGSFVFREFVLKDK--HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|| ..|.|..|.|.|||  |   .  .   |   .|.  |....| ||| .. .  .|.|...  .| .|||. ||...  .|..  .|..| 
ltqeeergkakvhryWPskgs..rsygklvvelkeev..elsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq
subfamily_Ptp69D_pd Subfamily Ptp69D 643-829 1.3e-35 118.1 In-house 25-214 (307) alignment 
Range on Protein: 643-829
Range on HMM: 25-214/307.0
LAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
.  || . ... |.  . . |  || |||| || ..| ||| | .   . . |||||....        ...|| |.|. .|  |||||. . ...|.||
akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik...gykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LTTVMESGRQKCHQYWPVTgEELQLAeGFSVRCLSEKpdETGSFVFREFVLKDKH-------EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
|. . |  |.||..|||.  .| |      |.. ||.  ... .. ||. .  |.       ..|..   .|..|.|  ||  ..  |.. |.||  
lsnlteknrkkcakYWpie.devqyg.dilvklvsee..khsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 643-830 1.6e-24 81.2 In-house 25-219 (305) alignment 
Range on Protein: 643-830
Range on HMM: 25-219/305.0
LAQYELMYRKNpDLAITEA-RKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMeiPGgAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLT
 |..  | | | |.   .| ..  .| ||||.|.   |  || | ..   .|| ||||    |    .|.| || ||  | .||| |  |.  . . || 
raefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..pt.npkrfictqaplektcadfwymclqdkveaifmlc

TVMESGRQKCHQYWPVT-GEELQLAEG---FSVRCLSEKP----DETGS-FVFREFVLKDK-HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
 ..| | .||..|..   ...|.. |.    ||.. | .     ... .     ..|..   ...|.. |  .  |||  ||.  .  ||. |. |...
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk
DSPc_SM00195 644-959 1.2e-74 246.3 In-house 4-262 (263) alignment 
Range on Protein: 644-959
Range on HMM: 4-262/263.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
...| . .....  .|||.|..|  ||||..| ||| ||| | ..    . |||||||....      ..|||||||| ||  |||||| .| ... |||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDEtGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTllqei
|  .|.|..||..||| . .. .  . .|| . ... ..  ... |.. |. .   |.| ....|| .|||| ||.... .||. . |.  ....     
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

eeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQR
                                                     ..|..||||||.||||.....|..|  .|. . |   .||. .|.||
.....................................................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

ACMVQNVSQYRFVCECICAAY
. |||.  ||.|..|.| ...
pgmvqtleqYlfiyeaileyi
PTPc_SM00194 644-959 1.2e-74 246.3 In-house 4-262 (263) alignment 
Range on Protein: 644-959
Range on HMM: 4-262/263.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
...| . .....  .|||.|..|  ||||..| ||| ||| | ..    . |||||||....      ..|||||||| ||  |||||| .| ... |||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDEtGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTllqei
|  .|.|..||..||| . .. .  . .|| . ... ..  ... |.. |. .   |.| ....|| .|||| ||.... .||. . |.  ....     
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

eeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQR
                                                     ..|..||||||.||||.....|..|  .|. . |   .||. .|.||
.....................................................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

ACMVQNVSQYRFVCECICAAY
. |||.  ||.|..|.| ...
pgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 644-833 9.2e-52 170.9 In-house 29-215 (293) alignment 
Range on Protein: 644-833
Range on HMM: 29-215/293.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYvnmeIPGGA-VNRYIATQGPLASTTTDFWRMVQQESSHLLVM
 .|| .   . | |.. |....|. ||||..| ||| .|| |    .. . |||||||    |||    . .||||||| .|. |||||| .. |. .||
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTTVMESGRQKCHQYWPVTGEELQLAeGFSVRCLSEKpdETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRT
|| ..| |..||..||| . |. .     .|  ..|.  |.  .| ||. .. ..|.|.........|||| ||.... .|.|...|| | ..|
ltqlvekgkvkCeeYWPadeepvlyG.dikvtlvaee..eledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 644-832 7.5e-46 151.5 In-house 19-205 (281) alignment 
Range on Protein: 644-832
Range on HMM: 19-205/281.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
 .|| ..  . | . | .....|  ||||..|. || ||| .    .. . ||||||.|.        ..|||||||. .. ..||.|| ... ...||.
eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy...kgekeyiatqgPvPaslvafWqmvweqkvsaivmv

TTVMESGRQKCHQYWPVTGEELQLAEgFSVRCLSEkpDETGSFVFREFVL-KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
|  .|.|. |||.|||   .||.... . |. ..|   |. ... |.| | ... |.|......|.||||| ||.... .||| . |. ....
treieagklkChrYWPddnselkygd.vtvkstae..eekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltek
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 645-831 1.4e-46 153.8 In-house 26-209 (288) alignment 
Range on Protein: 645-831
Range on HMM: 26-209/288.0
QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLT
.|. .   . . . | .|.. ||.|||||.| ||| .|| | .     . |||||.|.. |   .  ..|||||||||.|  |||..| .. .. .||||
eynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge...kkkkkyiatqgPladtvndfWelvyenktstivmlt

TVMESGRQKCHQYWPVTGEElQLAEGFSVRCLSEKpdETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
 ..| |..||..||| .... ..   . |  ...|  |...|| |.. |. |.....|...|||||||| || . . .||. . |  | .
elveggktkCeeYWPdadkp.knyGsvtvtlvesk..eledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 645-833 6.4e-31 102.4 In-house 25-210 (287) alignment 
Range on Protein: 645-833
Range on HMM: 25-210/287.0
QYELMYR-KNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVnSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTV
|. .. . .. .  .| .  . | .|||...| ..|  || |      ||||| ...        ...|....|...|  .||......  . .|||.  
qftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgy...kekkafiiaesPmfntarnfWkliddrnvtaivmlcqe

MESGRQKCHQYWPVTGEeLQLAEgFSVRCLSEKpdETGSFVFREFVLKDKH---EQRHIHHMQYLAWPDHC-VPSDPNLFLEFTERVRAARNRT
.|. ...|.|||| .   . | | .... |.|.   . ... |.. .| |.   ......  |. .|...  |..    .| . |.... | |.
kendeevcyqyWpeeks.vvlGe.yniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 645-833 1e-29 98.3 In-house 25-215 (290) alignment 
Range on Protein: 645-833
Range on HMM: 25-215/290.0
QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLV-----NSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
|.. .   . . ..| .  . | ..||...| .||  |. |      .  | .|||| |..        ..|||||||. .|  |||....||..  .||
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy...kekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTTVMESGRQKCHQYWPVTGEELqlAEGFSVRCLSEKPDEtgSFVFREFVLKDKHE---QRHIHHMQYLAWPDHC-VPSDPNLFLEFTERVRAARNRT
||...|.|..||.|||| .. .    . ||.. |.|.  .  ... |.. .|.|..   ...... |  .|...  |.      | ..|...  | |.
ltniieegkvkCqqYWpdsdtka..ygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg
subfamily_CG7180_pd Subfamily CG7180 645-833 1.5e-24 81.2 In-house 18-217 (296) alignment 
Range on Protein: 645-833
Range on HMM: 18-217/296.0
QYELMYRKNPDLAITEA---RKPANAPKNRYRDISPYDCTRVSLvNSLTG----DYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLL
.|.|.... | | | .     .  |  |||. .. ||| .|| | ..| |    ||||| ||.  .     . || |..|  .|  .|||.| .| .. .
eyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvL.ekldGeeksdYinavyvdsfl...kkkeyivteapkketvdefWrlvydeeisav

VMLTTVMESGRqKCHQYWPVTGeELQLAEGFsVRCLSEKpdETGSFVFREFVLKDK------------HEQRHIHHMQYLAWPD-HCVPSDPNLFLEFTE
|.|| ...  . ....||| .. . |  | | |  ..||  .   .. |.| |. |             |.| ....|.  |.  . ||.  | ..|. .
vvLtktfdfak.mypsywpnks.keqygeif.veiveek..qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

RVRAARNRT
|||  |...
rvrlwrekv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 646-833 8.7e-41 135.0 In-house 29-214 (319) alignment 
Range on Protein: 646-833
Range on HMM: 29-214/319.0
YELMYRKNPDlAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTT
..|.   ..|  ...| |. | .||||..| .|| ||| |    ..   |||||....        ...||||.||. |. |||||| .| |. .|||| 
fkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy...qerekfiatqaPlentiedfWrmvWeeessivvmltk

VMESGRQKCHQYWPVTgeElQLAEGFSVRCLsEKPDETGSFVFREFVLKDKHE---QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRT
. | .. |...||| .  .     |  .  | |. .|.  .. |.. |. | .    |.. | ||..|||| || .  . |.. .|.| .|..|
lveklkvklkkywpee..n.feeyGrlivtl.eeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt
subfamily_PTPN12_pd Subfamily PTPN12 647-831 1e-45 150.9 In-house 21-204 (290) alignment 
Range on Protein: 647-831
Range on HMM: 21-204/290.0
ELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT---GDYINANYVNMeiPGGaVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTV
.  |...     ....|. |  ||||.|| ||| .|| | .       ||||||...   . |   .|||.||||. | .|||||... . ...||.  .
sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..veg.kleyiaaqgPLpktlddfWrmiweknveivvmaCre

MESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGsFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
.| |..||..||| .|||    . |.| . .||  . . |. | . .. ..|.|... ..| ||||| ||| ..  ||..| ||  ..
velgkkkCerYWpeegeeelefgefevtleeekavddd.flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe
subfamily_PTPN13_pd Subfamily PTPN13 649-829 1.2e-44 147.6 In-house 20-198 (273) alignment 
Range on Protein: 649-829
Range on HMM: 20-198/273.0
MYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTgdYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGR
.    | .  ....| .|  |||||.. ||| ||| | .. .  ||||....... |    .|||.||||  |..|||.|| . ......|.|.  |.|.
lrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

QKCHQYWPVTG-EELQLAEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
 |||.|||..  ..|.. . . |. |     .  .|| |.. .||..  | |.. |... .|||| ||| .. .|.|  .||  
vkchrywPesknkklkvsnrlevellkv..qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl
subfamily_PTPN1_pd Subfamily PTPN1 650-829 1.3e-47 157.0 In-house 16-194 (290) alignment 
Range on Protein: 650-829
Range on HMM: 16-194/290.0
YRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTgDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ
 ..  |. ..||..|.| ..|||||.|||| .|. | .. . |||||. |..|    |  .|| |||||..|.. ||.|| .. |. .|||  |.| ...
rkeasdfptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvelee...akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCHQYWPVTGE--ELQLA-EGFSVRCLSEkpDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
||.||||   |  ||.|    ..|. .||  ...  .. | . |..   .| |.| |. |..|||  ||. |. ||.|  .|| .
kcaqywPqgeeekellledtklkvklise..erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres
subfamily_PTPRN_pd Subfamily PTPRN 650-827 3.7e-32 106.2 In-house 41-217 (297) alignment 
Range on Protein: 650-827
Range on HMM: 41-217/297.0
YRKNPDlAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPGGAVnrYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMES
|. .|  . . |... |. |||.... ||| .||.| .   . . |||||  .  . |  ..  ||||||||||| .|||.|| .. . ..|.||.. |.
yeaeps.tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa..yiatqgplastvadfwqmvweqGvvvivnltrleee

GRQKCHQYWPVTGEELQlaEGFSVRCLSEKPdETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVR
| ..|..||| .|.|.   . . |. .||.   .  .. | | ||.  ..| | .  . .|.||.. ||. .. .|||  .| 
gvkqckrywpdeGsevy..hiyevhlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn
subfamily_PTPRD_pd Subfamily PTPRD 651-831 7.4e-54 178.3 In-house 33-211 (564) alignment 
Range on Protein: 651-831
Range on HMM: 33-211/564.0
RKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG
....   ...|.|||| .|||| .| .|| .|| |    .    |||||....      . . |||||||||.|. |||||| .. |.  |||| . |.|
eegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr...krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkg

RQKCHQYWPVTGeELQLaEGFSVRCLSEKpdETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
..|||.||| .| . .  ... |   .|.  |   ...|.| ||  ...|.| ... .. .||||.||  .. .|.. ..|||...
kvkchkYWPekg.tety.geltVtleeee..eladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne
subfamily_eak_pd Subfamily eak 652-816 7.2e-12 39.3 In-house 38-198 (332) alignment 
Range on Protein: 652-816
Range on HMM: 38-198/332.0
KNPDLAITEARKPANAPKNrYRDISPYDCTRVSLVNSLTG--DYINANYvnMEIPGgAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ
... |.|.|...  .  .|   .| |||   | | .|      ||||    .| .    ..|| |  .  .    ||.|| .. |  .|.|   .| . .
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasl..aefse.vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle

KCHQYWPVTG-EELQLAeGFSVRCLSEkpDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDP
|  .|.|  . |||.    . | . .    . . . .| ..|.   |  ...| ..  | .  .|   
ksdkyfpdktreelkfG.ildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpkye
0049772 (Phosphotyrosine protein) phosphatases II 653-955 3.5e-36 120.9 In-house 33-276 (314) alignment 
Range on Protein: 653-955
Range on HMM: 33-276/314.0
NPDLAITEARKPANAPKNRYRDISPYDcTRVSLvN---SLTGDYINANYVNMEipggavNRYIATQGPLASTTTDF----------WRMV--QQESSHLL
 |.| |. |....|  |||| || |.| .|| | .     . |||||.||.        ...|||||||  |  ||          ||||  ..  .. .
lpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------LTTVMESGrqkcHQYWPVTGEELQlaegfsvrclsekpdetgsfvfrEFVLKDKHEQRHIHHMQYLAWPDHCVPsDP
||                     |..... |     .... . |.|.                       | .  ... .|.. .  .. .||...| ..
vmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk.......................eelydpelferlgikylripvpDgsap.ll

NLFLEFTERVRAArNrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaANPPVIVHCSAGIGRTGVLILMDTAL
. |.|| | ...| .                                                           .. ||.|||.||.||||......  .
edfdeflefieea.d...........................................................kggpvlvHCkaGkgRtgtfvvaaylm

ALMearePVYPLDIVRTMRDQRA-----CMVQNVSQYRFVCECI
 |.     | . .... .| .|       ....  || |. |..
kll....gvsleealedvrlkRpinpnpgfieqleqyefileal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 653-832 1.1e-33 111.5 In-house 30-208 (315) alignment 
Range on Protein: 653-832
Range on HMM: 30-208/315.0
NPDL-AITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNmeipGGAV-NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG
.||    . ||.. | .||||..| |.| .|| |    .|   ||||| |..    .    . |||.|||| ..  |||||| ||    .||.|   |. 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik....svdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegd

RQKCHQYWPV-TGEELQLaEGFSVRCLSEKPDetGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
. || ||||   ..  ..   ..|  || ..|  .  | |..|... .|.| .   |.  |||. |. .   .|..   |.| ...
kikcrqywPdrkadsvef.Gsikvellslead..tdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 653-828 7.2e-22 72.3 In-house 31-163 (392) alignment 
Range on Protein: 653-828
Range on HMM: 31-163/392.0
NPDLA-ITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGr
.||.   | |.|. | .||||..| ||| .|| |    ..   ||.|| |..      . . |||.||| |..  |||||| ||    ..|.| . |   
gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf...dnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.

qkchqywpvtgeelqlaegfsvrclsekpdetgsfvfrefvlkDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
                                             ...| .   ..  |||. ||   . .|.| . |.|
...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 653-757 8.4e-14 45.8 In-house 84-180 (244) alignment 
Range on Protein: 653-757
Range on HMM: 84-180/244.0
NPDlAITEARKPANAPKNRYRDISPYDCTRVSLVN-SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESgrqkc
.|   . .| .| |. |||     |.|  || | . |.   |||| .|      |    || || ||| |. |||.|. .    .||.| .| |      
dps.vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgcl...grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....

HQYWPV
 .||| 
deywpd
subfamily_PTPN23_pd Subfamily PTPN23 654-830 2e-41 136.7 In-house 33-204 (288) alignment 
Range on Protein: 654-830
Range on HMM: 33-204/288.0
PDLAITEARKpaNAPKNRYRDISPYDCTRVSLVnSLTGDYINANYVNMEIPGGavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
 . .|. |..  .. |||.||| ||| .|| |  . . ||||| .|.   ||     .||||.||.||  |||.|| .. | ..|||..  | |..|...
rkrsiaiakl..yseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgc..PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPVTGEELQLAEGFSVRCLSEKpdETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|||   .| .  . .|| . |..  ||. .| |.. |.  |... ... |.|. .||.. ||. |. .|.| . |..| 
YwPedkgetvkfgdlsvtlksvr..etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesay
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 654-811 3.3e-30 99.9 In-house 21-175 (283) alignment 
Range on Protein: 654-811
Range on HMM: 21-175/283.0
PDLAITEARKPANAPKNRYRDISPYDCTRVSLvNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
|||  . |    | .|||...| |.|  || | .|.. ||||| .. ..      ..||..|.||  |  |||.|| .|    .|||| ..|  |.|| |
pdldadiasadenkrknrnqeivpadqwrvel.ksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPVTGEElQLAEgFSVRCLSEKpdETGSFVFREFVLKDK---HEQRHIHHMQYLAWpDHC
|||  | | .  | | |    |      ||. .|..|. .   ...  . | |.  |  ..
yWPkrGse.dyGe.ftvtlrket..tsnsfiikelllrvnssakstlllahyqvidW.ley
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 655-832 3.8e-29 96.8 In-house 37-213 (325) alignment 
Range on Protein: 655-832
Range on HMM: 37-213/325.0
DLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHlLVMLTTVMESGRQKC
  | . | ||.|  |||.... ..| .|| |.    .   |||||.|.. ..     . ..|.| ||..|. |.||.| .  .  .|... ... | ..|
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk...kkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrc

HQYWPVT-GEELQLaEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
 .|||   |.  ..  |. |.  .   .|   .| | . .|. .  | | .. .|. .|.|  |.  |  .. ... | |  .|
avywpkemgksktf.Gglevklrti..eeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser
subfamily_egg_pd Subfamily egg 656-804 4.9e-20 66.4 In-house 30-179 (307) alignment 
Range on Protein: 656-804
Range on HMM: 30-179/307.0
LAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESgrQKCH
 ..|.| .  |  | | . .   | .|| |       ..|.| ||.|.    .  .| .| .| ||  |  |||||| ||  . .||||.  ||  ..|.
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPVTGEELQLA--EGFSVRCLSEKPDETGSFVF-REFVLKDKHEQRHIHHMQY
 ||| . ..       .. . .|  .      |   .  ..  ..|.|.. | |.
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 657-831 5.2e-42 139.1 In-house 47-219 (298) alignment 
Range on Protein: 657-831
Range on HMM: 47-219/298.0
AITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
  . ||||.|  |||| || ..| .|| | .      .||||| ...        | .||||.|| .|..|||||| .| .  .||||.. |... |.|.
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh...aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPVTGEELqlAEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
||| .|.|    . ..|. ||.  .| . .. |.. ...|.  ..|.......  |||..||.  .  |.. ..||| ..
ywPdegket..ygeitvsllsk..eefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq
subfamily_PTPN6_pd Subfamily PTPN6 658-832 2.2e-54 179.6 In-house 46-221 (306) alignment 
Range on Protein: 658-832
Range on HMM: 46-221/306.0
ITEARKPANAPKNRYRDISPYDCTRVSL-VNSLTG-DYINANYVNMEIPGGAvNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
 .|..|| |. ||||. | |.| |||.|  .|..| |||||||.. |..|   ..|||||| | .| .|||||| ||.|...||.|. .| |..|| .||
rkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW

PVTGEELQlAEGFSVRCLSEkpDETGSFVFREFVL---KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
| . |. .     ||...||  ... ....||...   |.|.|.|....... .|||| ||.||. .|.| | |.. ...
Pdeeekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 658-829 1.9e-31 104.6 In-house 53-217 (319) alignment 
Range on Protein: 658-829
Range on HMM: 53-217/319.0
ITEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTtvmesgRQKCHQY
 | |  . |  |||. .| ..| ..| | .       ||||| .|.        ..|||.||||  |  |||||. .  .  .|.||      ..|| ||
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy...qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPVTGEELQLAEGFSVRCLsekpDETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
||  ... .     .|  .    .||  .| |.. | .   ....|.|.   .| |||. ||  |  .. . ..||  
wplkivikeerfkvkvdsv....eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 658-827 6.2e-28 92.8 In-house 43-209 (297) alignment 
Range on Protein: 658-827
Range on HMM: 43-209/297.0
ITEARKPANAPKNRYRDISPYDCTRVSLV--NSL-TGDYINANYVNmeipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRqKCHQY
 | |.|  | .|.||..| |||  || |   |.    ||.|| .|.     |  .|.|.|| |  .|  |||.|| .|    .|||.   |. . || .|
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk.....gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPVTGEELqlAEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPS--DPNLFLEFTERVR
|. .|         ||  ||   .|   |. ||....  .   .| ..  |.. |||. |.   . . .|.. . ||
Wsdkgvtt..fGdvsvvllsv..sereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 658-830 4.6e-25 82.8 In-house 29-200 (281) alignment 
Range on Protein: 658-830
Range on HMM: 29-200/281.0
ITEARKPANAPKNRYRDISPYDCTRVSLV----NSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
 |   .| |  |||| .|   | .|| |     |  . ||| |||.   .       || ||||   | .|||||. || .  .|||  ..|. |.|| .
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf...lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPVTGEELQLAEGFSVRClsEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|.|         . .||    |      |.|   . |  . | | | |  .  |||  ||   ...|.   ..||  
yfprnahcclqfdklsvsy..edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars
0042113 (Phosphotyrosine protein) phosphatases II 659-956 1.7e-70 232.5 In-house 2-240 (245) alignment 
Range on Protein: 659-956
Range on HMM: 2-240/245.0
TEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVnmeiP-GGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY
. |..|.| .||||.|| ||| ||| | .    |  |||||.||    .     ...|||||||..|. |||||.... .. .||||. .| ||.||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRaarnrtllqeieeslkqvrlmdada
||   .| .  ..|.|..|||.    .... |.. ..   ..|.|...|..|| ||||.||....|.|.| |.||                         
wpl..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr.........................

dadengglmrerkcaasngatpedetpvstsvhQCIS-AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFV
                                 ....  .| ||.||||||.||||..|.....| ..|..  | . ..|. .|.|| ..||. |||||.
.................................kalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

CECIC
 |...
yeall
0040439 (Phosphotyrosine protein) phosphatases II 659-957 5.4e-70 231.1 In-house 4-244 (249) alignment 
Range on Protein: 659-957
Range on HMM: 4-244/249.0
TEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPGGAvnrYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
..|..|.| .||||.|| ||| .|| |        .|||||.|...   . .   .||||||| .|. |||||.... .. .||||. .| ||.||.|||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr...fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRaarnrtllqeieeslkqvrlmdadad
|   .. .  ..|.|..||..    .... |.. |.   . | |...|.||. |||| ||.... .|.| |.||                          
pl..ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr..........................

adengglmrerkcaasngatpedetpvstsvhQCIS--AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFV
                                ....    . ||.||||||.||||..|.....| ..| .  | ....|...|.|| ..||| .||||.
................................kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

CECICA
.|... 
yealle
subfamily_CG42327_pd Subfamily CG42327 659-955 2.2e-38 126.7 In-house 21-311 (319) alignment 
Range on Protein: 659-955
Range on HMM: 21-311/319.0
TEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
...  ..  .|.|. .. |   ||| | .        |..|.||    .  | | |||.| .| ....||||.| .  |  .| || . | | ..| .|.
adevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrG..yddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeyl

PV--TGEELQLAEGFSVRClseKPDET-GSFVFREFVLK--DKHEQRHIHHMQYlAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDA
|   |... .|   . |     |  |.   ..   ..||  ||.| |.. |  |  |..  ||.... ..    .||.. .   |.. .|  ..   ...
PtketldntslyGdilvtl...kgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslksysleqanelreksatlet

DADADENgglmrerkcAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAR-EPVYPLDIVRTMRDQRACMVQNVSQYR
  ||| .          |  |.|   |     | .      . |..|||| |.||||..|  | |.  .|   . |   ..|  .| .||  |... || 
smdadgs.........kaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqye

FVCECI
|.   .
fiykvl
subfamily_PTPRK_pd Subfamily PTPRK 659-830 1.2e-36 121.2 In-house 36-206 (314) alignment 
Range on Protein: 659-830
Range on HMM: 36-206/314.0
TEARKPANAPKNRYRDISPYDCTRVSLVNsLTG----DYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY
  |.|  |  |||. || .|| .|| |.  . |    |||||....        . .|.||||| .|..||||.| .| .  .|||| ..| || || .|
daakkdenreknrsgdilaydrsrvflit.idgdpssdyinaalidsy...krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

WPVTGEElqlAEGFSVRCLSEKPDEtgSFVFREFVLKD----KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
||  .|     . . | ... ....   .| | | ..     ..|.| ....|.|.|||| ||   . .|..  || . .
WPedtev...ygdikvelvetella..elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 659-823 8.3e-34 111.7 In-house 31-194 (287) alignment 
Range on Protein: 659-823
Range on HMM: 31-194/287.0
TEARKPANAPKNRYRDISPYDCTRVSLVN--SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWP
 .| . |.. |||| |. |.| ||| |..   |  ||||||||         ...||.|||.|.|  ||||.| .. |  ....|  .| .|.||..|||
kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasy...tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

VTGEELQLAeGFSVRCLSEKPDETGsFVFREFVLKDK--HEQRHIHHMQYLAWPDHCVPSDPNLFLEFT
     ...  |.||  |. .  |   .  | . | |   .| | .. ...|.|||. ..     .. |.
erevPmrvG.GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfv
subfamily_PTPRA_pd Subfamily PTPRA 659-831 1.6e-33 111.0 In-house 51-225 (330) alignment 
Range on Protein: 659-831
Range on HMM: 51-225/330.0
TEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
  | |  |  |||. .| ||| .|| | .     . ||||| ...        ...||.|||.. |  |||||. .  |. .|||| . |  ..||.|||
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy...kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PVTGeelQLAEGfSVRCLSEKPDETGSFVFREFVLK------DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
|  |    .. |  .|   |.  .. ..  |.|...      .....| .. . . .|||  ||..|   |.. ..|.. ..
PdeG...lvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 659-829 6.8e-31 102.8 In-house 18-181 (284) alignment 
Range on Protein: 659-829
Range on HMM: 18-181/284.0
TEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTtvmesgRQKCHQYW
| |  . |  |||. .| ..| ..| | .       ||||| ...        ..||||||||  |  |||||. .  .  .|.||      ..|| |||
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy...qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PVTGEELQLAEGFSVRCLsekpDETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
|  ... .     .|  .    .|.  .| |.. | .   ....|.|. . .| |||. ||  |  .. . ..||  
plkivikeerfkvkvdsv....eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 659-832 1.6e-30 100.7 In-house 36-207 (515) alignment 
Range on Protein: 659-832
Range on HMM: 36-207/515.0
TEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNmeipGGA-VNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY
| |..  | .||||..| ||| .|| |    ..   ||.|| |..    .    . |||.|||. ... ||||.| ||    ..|.|   |. . || .|
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip....sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky

WPV-TGEELQLAEgFSVRCLSEKPDeTGSfVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
||   |. ... . ..|  .| . . ||  . |.. .    . | .   ..  |||. || . . .| .   |.| ...
WPdkpgdsvkfGs.ikvelvsleac.tgg.ikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 659-829 1.8e-28 94.4 In-house 42-207 (315) alignment 
Range on Protein: 659-829
Range on HMM: 42-207/315.0
TEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
  |.|  |  |||| .| .|| .|| |    |    ||.|||...        .||||.|||....  ||||.| .|    .|||| ..|  ..|. .||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy...nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PVTgeELQLAeGFSVRCLSEKPDEtgSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
|    ..     ..|   ||.  .   .  | .    . . |..  ..| .|||  ||     ....  .|.  
pdk..kviyG.kitvtrkseevnt..eytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh
subfamily_ptpA1_pd Subfamily ptpA1 659-830 9.6e-26 85.4 In-house 40-219 (418) alignment 
Range on Protein: 659-830
Range on HMM: 40-219/418.0
TEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPggavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
.|  |  |. |||| .| | . ||| | .       |||||||..   |    ...|.|||||  | .|||||| ..  ...|||.   |  | || .||
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp....kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

P--VTGEELQL-------AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|  . ||.. .          .||  .    |     . |.  |  . | | | . ||  |||| .|   . | ..   .   .
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 659-816 1.5e-12 41.7 In-house 40-190 (303) alignment 
Range on Protein: 659-816
Range on HMM: 40-190/303.0
TEARKPANAPKNRYRDISPYDCTRVSLVNSltgDYINANYVNMEipggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVT
.  .   |  |||. |.   | ..| | .|    || |.|....    . .. | || ||. |..|||.|. ..  . ...| |  |  .   .  .|  
sknqfvknmdknrfvdvicldhskvklsds...syihasyleld....sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

GEELQLAEGfSVRCLSEKPDET-GSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDP
 . |.. |  |.|    |  |    .|..   . . . .  .|  .| |||   .||| 
qdflkfeer.sirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdg
0037934 (Phosphotyrosine protein) phosphatases II 660-956 2.3e-69 228.9 In-house 4-239 (243) alignment 
Range on Protein: 660-956
Range on HMM: 4-239/243.0
EARKPANAPKNRYRDISPYDCTRVSLvNSltGDYINANYVNMEiPggavnRYIATQGPLASTTTD----FWRMVQQESSHLLVMLTTVMESGRQKCHQYW
 |..|.| .||||.|| |||..|| | ..  .||||||....  |     |.||||||| .|. |    ||||.... .. .||||. .| ||.||.|||
iallpenlsknrysdilpydhsrvkl.eg..sdyinanliyvt.p.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PvtGEElqLAEGFSVRCLSEKPdeTGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEieeslkqvrlmdada
|  ||.    ..|.|..|||.   ..... |...|.    ....|...| .||.||||.||..|. .|.| . ||.  ...|.                 
p..gev..tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll...............

dadengglmrerkcaasngatpedetpvstsvhqcISAANPPVIVHCSAGIGRTGVLILMDTALALMearePVYPLDIVRTMRDQRAC-MVQNVSQYRFV
                                       . ||.||||||.||||.||.... | |.     | ....|...|.|| . .||. |||||.
...................................aldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfl

CECIC
 |...
yeall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 661-832 1.3e-39 130.9 In-house 4-172 (250) alignment 
Range on Protein: 661-832
Range on HMM: 4-172/250.0
ARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMEIpgGAvNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQkCHQYWPV
|.||.|  |||| || ..| .|| | ..      ||||| ...     .  . .||||||| .|. |||||| .| |  .||||.. ||... .||||||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd..er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

TGEElqLAEGFSVRCLSEkpDETGSFVFREFVLKDKHEQR--HIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
 . |     .  |  ||.  .| . .. |...|  ....   .. ......||| .||   .  ||. ..|.| ...
ekae..kyGdvtvsllsk..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 661-815 3.7e-27 90.0 In-house 3-155 (239) alignment 
Range on Protein: 661-815
Range on HMM: 3-155/239.0
ARKPANAPKNRYRDISPYDCTRVS---LVNSLTGDYINANYVNMEipGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV
|.|  |  |||| .|  || .||    | |    |||||.|.      |. . |||||| .. .. |||||. ||   ..|||| ..|  ..||||||| 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TGEELqlaegFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSD
.  .        .|    | .    .. | ||. .  . |.|.... ..  |||. ||  
stsky.....cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 661-815 4.6e-27 89.7 In-house 2-154 (239) alignment 
Range on Protein: 661-815
Range on HMM: 2-154/239.0
ARKPANAPKNRYRDISPYDCTRVS---LVNSLTGDYINANYVNMEipGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV
|.|  |  |||| .|  || .||    | |    |||||.|.      |. . |||||| .. .. |||||. ||   ..|||| ..|  ..||||||| 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TGEELqlaegFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSD
.  .        .|    | .    .. | ||. .  . |.|.... ..  |||. ||  
stsky.....cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 661-831 8e-24 78.9 In-house 43-208 (439) alignment 
Range on Protein: 661-831
Range on HMM: 43-208/439.0
ARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRqkchqYWPV
| .  . .||||.|....| ||| |          ||||||..        . |||||||   || ||||.| .. .  .|||| ..|| .     ||| 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy...ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

TGEELQlaEGFSVRClsEKPDETGSFVFREFV---LKDKH-EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
 .|        .||.  ..  |   .| | |     .|.   .| . ...|.||||. ||..    |.|   . .| .
daevcy..gdiavrv..drnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 661-716 1.4e-09 32.0 In-house 43-95 (95) alignment 
Range on Protein: 661-716
Range on HMM: 43-95/95.0
ARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEipgGAVNRYIATQG
    || ||||. .| |||.||| |      ||||| .|.        | |||.||
gsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy...arkncyiaaqg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 662-959 5.2e-58 191.3 In-house 24-268 (274) alignment 
Range on Protein: 662-959
Range on HMM: 24-268/274.0
RKPANAPKNRYRDISPYDCTRVSL----VNSLTGDYINANYVNMeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV
. . .. ||||..| | . .||.|    ...   .||||||.    ...  . |.||||||..| .|||||. ||.....|||| . |. .|||..|.| 
dvfgsqtknryktilPnensrvllesessededssyinanyikG..ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

TGeELQLAEGF-SVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVraarnrtllqeieeslkqvrlM--------
.  .....| .  |    ||  |.  .  |..|||  ...|...|. | .|||| .| |.| .|.. . |                              
ae.dyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev.....................eesreeena

----DadadadengglmrerkcaasngatpedetpvstsvhqcisaanppvIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQN
                                                   .|||||||||||. | .. |.  ..... |  | ||  .| .|  |||.
klapv..............................................vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt

VSQYRFVCECICAAY
 .||... . .|   
seqyelihralclyl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 662-827 2.1e-21 71.1 In-house 31-197 (285) alignment 
Range on Protein: 662-827
Range on HMM: 31-197/285.0
RKPANAPKNRYRDISPYDCTRVSLVNSlTGDYINANYvnMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEE
   ||   ||| |.   . ||| | |    ||| |..  | .||   . ||.|||||  | .|||.|. ||    ..|| |..| | .||  |.|    |
ayeanpdlnryadvrcieetrvvlknh.drdyihasw..mrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

LQLAEGFSVRCLSEKPDETGSFVFREFVLKD----KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVR
.     . .     | .     ..  . . .      |  .. |.|   |||.  | |   ..|. . |.
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 665-824 5.6e-22 72.8 In-house 49-208 (301) alignment 
Range on Protein: 665-824
Range on HMM: 49-208/301.0
ANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL
 .  |.||  .     | | ...  .   | ||... .   |  .|.||||||| .|. ||| |..|   . .|||.  .|   .||..| ||. .|   
lpkdkhryptvPckPstavevivdGkrvPihanwipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

AEGFSVRCLSEKPDETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE
 . |...  ...     . . |.. ..|   | . | . | ||  |.|. ||       .. |
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 665-830 4e-19 63.7 In-house 42-204 (288) alignment 
Range on Protein: 665-830
Range on HMM: 42-204/288.0
ANAPKNRYRDISPYDCTRVSLVNSlTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV-TGEELQ
||. ..||...   | ||| | .  .  ||.|| |     .   .| | .| || .|   .|.|. ..  . .|||. ..| |..|  .|.|.  ||. .
anptrdryenlprcditrvklsdd.pdfyiaanvvs...sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

LAEGfsVRCLSEKPDETGSFVFREFVLKDKHEQRH--IHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
.          .| ..    |    .   |. . .  . .. .| |.|..|| .   .| . |.... .
igrl..ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 665-798 2e-14 48.3 In-house 32-156 (267) alignment 
Range on Protein: 665-798
Range on HMM: 32-156/267.0
ANAPKNRYRDISPYDCTRVSLVNSlTGDYINANYVNMEIPGgavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVmesGRQKCHQYWPVTGEELQL
 |. .||. |  ||| ||| | .. . .|||| ||.    .   | .|.||.||  | |||. .....     |.||.|   . .. ...||    . . 
knqernrlddnlpyddtrvilrtk.eeeyinasyvegyktk...nafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

AEGFSVRCLSEKPDETGSFVFREfvLKDKHEQRH
 . ..|    || ..    .  |  || | |  |
yqdltvehslekeendyqiitle..lkfknesah
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 665-764 6.3e-06 19.8 In-house 50-147 (302) alignment 
Range on Protein: 665-764
Range on HMM: 50-147/302.0
ANAPKNRYRDISPYDCTRVSLVNsLTGDYINANYVnmEIPGGAvNRYIATQGPLASTT---TDFWRMVQQESSHLLVMLTTVMESGRqKCHQYWPVTGEE
.|  ||.  |.  .| ..| | .    .|.||  |  |.|    .  | .| |  ...    .||||| ||.   .|.|    |  .   ....| . ..
knlkknqsedvpildsnlvklea.epdsyvnaskv..evPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

LQL
 . 
yke
Y_phosphatase Protein-tyrosine phosphatase 666-955 2.3e-71 235.3 Pfam-A 1-233 (235) alignment 
Range on Protein: 666-955
Range on HMM: 1-233/235.0
NAPKNRYRDISPYDCTRVSLVNSL-TGDYINANYVNMEIPggaVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL
|  ||||.|| ||| ||| | .|  . ||||||||..       ...||||||| ||  |||||| || ....||||...|.||.||.|||| . || . 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQ---RHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglm
 . ..|.. ... ... ....|.. ||.| |.   |......| .||||.||..|. .|.. ..|.  .                               
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...............................

rerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
                           .| . ||.||||||.||||.....|..|  .||.| |  |.||...| ||. |||...|| |....|
...........................eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 666-955 2.3e-71 235.3 In-house 1-233 (235) alignment 
Range on Protein: 666-955
Range on HMM: 1-233/235.0
NAPKNRYRDISPYDCTRVSLVNSL-TGDYINANYVNMEIPggaVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL
|  ||||.|| ||| ||| | .|  . ||||||||..       ...||||||| ||  |||||| || ....||||...|.||.||.|||| . || . 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQ---RHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglm
 . ..|.. ... ... ....|.. ||.| |.   |......| .||||.||..|. .|.. ..|.  .                               
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...............................

rerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
                           .| . ||.||||||.||||.....|..|  .||.| |  |.||...| ||. |||...|| |....|
...........................eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0041856 (Phosphotyrosine protein) phosphatases II 666-959 1.9e-45 150.0 In-house 1-171 (182) alignment 
Range on Protein: 666-959
Range on HMM: 1-171/182.0
NAPKNRYRDISPYDCTRvslvnslTGDYINANYVNMEIPGGAvnrYIATQGPLASTTTDFWRMVQQESSHLLVMLTtvmesgrqkCHQYWPvtgeelqla
| .||||.|| ||| .|         ||||||.. .  |.     .||||||| ||. ||.||....  ...|.||         ...|||         
nldknrysdilpydhsr.......dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

egfsvrclsekpdetgsfvfrefvlkdKHEQRHIHHMQYLAWPDHCVPSdPNLFLEFTERVRAarNrtllqeieeslkqvrlmdadadadengglmrerk
                           ....|.... .|| ||||.||. .. .|.| |.|..  .                                  
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..e..................................

caasngatpedetpvstsvhqcisaaNPPVIVHCSAGIGRTGVLILMDtalaLMEAREpVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
                          . ||.||||||.||||.|....    ||. .. | . ..|...| .| .||.. .||.|.  ...  .
..........................ggpvlVHCsaGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 666-817 5e-37 122.3 In-house 20-172 (270) alignment 
Range on Protein: 666-817
Range on HMM: 20-172/270.0
NAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNmeIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEEL
..  |||.|| |   ||| | .     .  |||||||.     |. ..|||..|||..|...||||. .| .. .||.| ..| ||.|| .|||   .| 
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr..GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

QLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPN
   |   .. |...   .  .....  |..| |.|.. | .| .|||| ||....
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreed
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 666-826 4.9e-32 106.0 In-house 3-162 (237) alignment 
Range on Protein: 666-826
Range on HMM: 3-162/237.0
NAPKNRYRDISPYDCTRVSLVNSL-TGDYINANYVNMeIpGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELql
|  |||| .|  || .|| |  .  . |||||.|..  .  |. ..|||.|||| |.  |||.|| ||   ..|||| ..|. ..|||.||| | .    
nkiknrygnivaydhsrvvlkgagsgsdyinatylkg.f.dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa..

AEGFSVRCLSeKPDETGSFVFREFVLKDKH---EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
| |     |  | .|   .  | ..|  ..   | | ||  |. .|||. ||     .| |  ..
aygvltvslk.kkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 666-830 6.4e-26 85.7 In-house 55-221 (305) alignment 
Range on Protein: 666-830
Range on HMM: 55-221/305.0
NAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV-TGEELQL
.  ||||.|.   | . | | .    ||| ||||    |    .|.|..||||  |  .|| || |.    .|||   .| |. || ||||.  || |.|
aitknryqdvpcqdqsavkldkpspsdyihanyvgc..pmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

AEGFSVRCLS-EKPDETGSFVFR-EFVLKD-KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
  |  |  .|  || |  . .    . |     ..  . |.|.  |||  ||      ||.   .| ..
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 666-731 3.8e-06 20.6 In-house 37-107 (347) alignment 
Range on Protein: 666-731
Range on HMM: 37-107/347.0
NAPKNRYRDISPYDCTRVSLVNS-----LT---GDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQ
.  ||| .|    | ||| |         .     |||| .....    | . || || || .|  |||.||. 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfd...naskeyiltqyplpdtvrdfwkmvsv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 667-826 4.2e-33 109.2 In-house 57-212 (290) alignment 
Range on Protein: 667-826
Range on HMM: 57-212/290.0
APKNRYRDISPYDCTRVSLVNSLTGDYINANYVNmeipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAE
  ||||.|.   | ||| | .   |||. ||||.     |    .| |||.|..|. |.|||| ||    .|||  ..| |. ||.||.| .  |     
fkknrykdvvcndktrvilkdGydGdyvhanyvk.....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

GFSVRCLSEKpDETGSFVFREFVLKDKHE--QRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
 ..| |  |. |.    . . . ..||..  .  ..|..  .|||..|.     .|     .
eitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 667-758 2.5e-25 83.9 In-house 48-153 (350) alignment 
Range on Protein: 667-758
Range on HMM: 48-153/350.0
APKNRYRDISPYDCTRVSLVN-----------SLTGDYINANYVNMEIPGGAVN---RYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCH
  ||||..| ||. .|| | .             | |||||||.... ..  .|   .|||||.|| ||  ||.... .   .....||. .| ...||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPVT
.||.  
rYWqeg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 667-755 7.5e-14 45.8 In-house 49-153 (349) alignment 
Range on Protein: 667-755
Range on HMM: 49-153/349.0
APKNRYRDISPYDCTRVSLVNSL-----------------TGDYINANYVNMEIPgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ
  ||||.|| ||. .|| | .||                   |||||||...     . ..||||| || ||  ||....  .  .|.. |.   | . .
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltri.svekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHQYW
||..||
kcdiyw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 670-815 1.2e-13 45.4 In-house 47-194 (312) alignment 
Range on Protein: 670-815
Range on HMM: 47-194/312.0
NRYRDISPYDCTRVSLVNSlTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL--AEG
||| .|  .|  | .|       || ||.|..       .|...||||| .|.| ||...   .|  ...|....| | .|| .|       ..|     
nrypniqcwdrgrftlagd.enfyihanfvkict...kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

FSVRCL----SEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSD
..  |       |  .  .      |.|   .. .. | |. .|||| .|  
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds
0044763 (Phosphotyrosine protein) phosphatases II 677-954 3.3e-31 103.7 In-house 1-166 (178) alignment 
Range on Protein: 677-954
Range on HMM: 1-166/178.0
PYDCTRVSLVNSLT---GDYINANYVNmeiPGgavnRYIATQGPlasttTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEelqlaegfsvrcl
|.| |||.| |      .|||||...    ||     |.....|      |........  ...|.||. .| |..||..|||   .             
pldrtrvllsnleglersdyinaseil...pg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............

sekpdetgsfvfrefvlkdkheqrhiHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglmrerkcaasngat
                           ..... .|||.||. .  ||||.| ...|.                                           
..........................iqylhipipDhgvpdllehflefvefieeal...........................................

pedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLIlmdtALALMEARePVYPLDIVRTMRDQRAcMVQNVSQYRFVCEC
               .  . ||.||||||.||.|.|.    |. ||  .  . . .... .| .|  .|.| .|.|...|.
...............dekggpvlVHCsaGvgRsgtlv....aaylmkkl.glsleeaielvrerRp.ivpnpgqlrqLyef
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 677-757 2.1e-08 28.5 In-house 4-71 (130) alignment 
Range on Protein: 677-757
Range on HMM: 4-71/130.0
PYDCTRVSlvnslTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESgrqkcHQYWPV
... .|.        .||||..| .    |  . |. || ||| |..|||.|. .    .||.| .| |       .||| 
efevsrlq.....gntyinasfvGll...grtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 687-828 4e-17 57.3 In-house 42-189 (290) alignment 
Range on Protein: 687-828
Range on HMM: 42-189/290.0
NSLTGDYINANYVNMeiPGGavNRYIATQGPLA-------STTTDFWRMVQQESSHLLVMLTTVMESGRQ----KCHQYWPVT-GEELQLaEGFSVRCLS
. .. ||| ||.| .  | |   | |.|| |..       ||  .|| |..|| .. .|||  ..|  ..     | .| | . ||||.. .|..|.| |
krfnddyiHAnrvtc..png..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf.kgltvkCks

EKPDEtgSFVFREFVLK-DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
   ..   .  || |.| |..|.  . | ..  | .  |. |. ..|.  . |.|
keked..dvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvka
0046846 (Phosphotyrosine protein) phosphatases II 690-832 3.8e-21 71.1 In-house 11-108 (176) alignment 
Range on Protein: 690-832
Range on HMM: 11-108/176.0
TGDYINANYVNMEipggavnRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVtG-EELQlaegfsvrclsekpdetgsfvfref
  ||||||.. .        |.||||||| .|. ||..|....  ...|.||. .| || ||..|||.   ..                           
dldyinanlilgs.......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi.........................

vlkdkheqrhihHMQYLAWPDHCVPSDpNLFLEFTERVRAARNR
            . ..| ||||.||.. .|.||. | .| |...
............qylhlpwpDhgvpdl.elllellefirealke
0036282 (Phosphotyrosine protein) phosphatases II 691-952 4.2e-43 142.4 In-house 2-163 (174) alignment 
Range on Protein: 691-952
Range on HMM: 2-163/174.0
GDYINANYVNMEIPGGavnRYIATQGPLAstttdFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVtgeelqlaegfsvrclsekpdetgsfvfrefvl
 |||||..... .  .   |.||.|||||     ||.|....... .|||.. .| |. ||..|||                                  
sdyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

KDKHEQRHIHHMQYLAWPDHCVPSDPNlFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisA
. ... |.... .|| ||||.||...  .||| ..|. |.                                                           .
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal...........................................................s

--ANPPVIVHCSAGIGRTGVLILMDTALALMEaREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
   . ||.||||||.||||.|....  | ...   .|  ||.||..| || .|||. |||||. 
edpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0043147 (Phosphotyrosine protein) phosphatases II 691-952 2.2e-39 130.3 In-house 5-154 (172) alignment 
Range on Protein: 691-952
Range on HMM: 5-154/172.0
GDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVmesgrqkchqywpvtgeelqlaegfsvrclsekpdetgsfvfrefVL
 |||||.|... .     .|.||||||| .|. |||||....  ...|.||.                                              ..
sdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

KDKHEQRHIHHMQYLAWPDHCVPsDPNLFLEFTERVRA--ARNRtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqci
  ....|.. . .|| ||||.|| ...|.||| | ..   |...                                                        
dpellerlgiqylylpwpDhgvp.llellleflefidellalsp........................................................

saaNPPVIVHCSAGIGRTGVLILMDTALalmearEPVYPLDIVRTMRDQRACMVQNVSQYRFVC
   . ||.||||||.||||.|....  |      . . ....|...|..| ..||| |||||..
...ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 691-833 4.4e-24 81.0 In-house 4-152 (272) alignment 
Range on Protein: 691-833
Range on HMM: 4-152/272.0
GDYINANYVNMEipgG---AVNRYIATQGPLASTTTDFWRMvQQESSHLLVMLTTVMESGRQKCHQYWP--------VTGEELQLAEGFSVRCLSEKPDE
..||||..|..    |     .|.....|||  |  ||||. ...  .  |.|....| ||.||..|||        . ... .  . . .|    .   
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TGSFVFREFVLK---DKHEQRHIHHMQYLAWPDHCVPSDPnlFLEFTERVRAarNRT
.  .. ||..|.   . .| |...|..|..||||.||...  .||. | ...  .. 
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..ggp
0051082 (Phosphotyrosine protein) phosphatases II 692-953 7.5e-29 95.7 In-house 4-147 (151) alignment 
Range on Protein: 692-953
Range on HMM: 4-147/151.0
DYINANYVNmeipGGavnrYIATQGPLAstttDFWRMVQQESSHLLVMLTTVMESGrqKCHQYWPVTGeelqlaegfsvrclsekpdetgsfvfrefvlk
||||..||     ||    .....||||    ||.......     |.|.. .| |  .|..|.| .|                                
dyinfsyvt....gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

dkheqRHIHHMQYLAWPDHCvpsdpnlfleftervraarnrtllqeieeslkqvrlmdadadadengglmrerkcaasngaTPEDETPVSTSVHQCISAA
     ....|...| |||.                                                              .|.    |   ......  
.....ievlhipildwpdpg.............................................................lplsfdavleflellldkk

NPPVIVHCSAGIGRTGVLILMDTALaLMearepVYPLDIVRTMRDQRACMVQNVSQYRFVCE
| ||.||||||.||||.|....  | |.     | . .... .| .|  .||   |..|.  
ngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfqlf
0049260 (Phosphotyrosine protein) phosphatases II 709-828 3.1e-17 58.1 In-house 9-83 (152) alignment 
Range on Protein: 709-828
Range on HMM: 9-83/152.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWpvtgeelqlaegfsvrclsekpdetgsfvfrefvlkdkheqrhihHMQYLAWP
...||||||.  |. |||||...   . .||||. .| |. ||.||.                                             . ..| ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHCVPSDPNLFLEFTERVRA
||.||... |.|.. . .. 
Dhgvpdlsqlllflllfiek
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 709-823 2.2e-10 35.1 In-house 4-119 (198) alignment 
Range on Protein: 709-823
Range on HMM: 4-119/198.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSV--RCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLA
 |||||| ||  | .|||.|| .  |  .||.             |||.|         .||  .... ||| | . .            | | | |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHCVPSdPNLFLEFT
| ..  |    ||. | 
wkekttpn.valfvgfv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 709-823 2.4e-10 34.9 In-house 5-120 (199) alignment 
Range on Protein: 709-823
Range on HMM: 5-120/199.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSV--RCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLA
 |||||| ||  | .|||.|| .  |  .||.             |||.|         .||  .... ||| | . .            | | | |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHCVPSdPNLFLEFT
| ..  |    ||. | 
wkekttpn.valfvgfv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 709-810 5.9e-09 29.7 In-house 236-331 (440) alignment 
Range on Protein: 709-810
Range on HMM: 236-331/440.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMEsgrQKCHQYWPVTGEELQLAeGFSVrclSEKPDE-TGSFVFREFVLKDKHEQRHIHHMQYLAW
| .|||| || ||  ||||.|..     ..||  . .   . |  ||||    . .   |.|     |  |       | . || | |   |  ..  .|
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfg.pftv...ghkgsenmnrvkvrtlelkykeevheirqfevqtw

PDH
|  
ptw
subfamily_hpo-7_pd Subfamily hpo-7 713-829 2.5e-10 34.7 In-house 42-154 (263) alignment 
Range on Protein: 713-829
Range on HMM: 42-154/263.0
AtqgpLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDET-GSFVFREFVLKdKHEQRHIHHMQYLAWPDHC
     |  |   |.....|  .. .|||.   | |..|| .|.|.  .| |  .  .| .   . |    . .. . . . | . . ..| .|  |... 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekn

VPSDPNLFLEFTERVRAA
 | ...  |.  . .|  
dpelareilnilkvarns
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 716-822 6.3e-07 23.1 In-house 98-213 (302) alignment 
Range on Protein: 716-822
Range on HMM: 98-213/302.0
GPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV-TGEELQLAEgFSVRCLSEKP------DETGSFVFrEFVLKD----KHEQRHIHHMQY
 |  ||.  .| ...| .  . | |....|.. .|| .|.    |.||.. . ..|. .| |       |  .  ..    .|.    |. .. .. ...
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgr.ytvktvsvktdleeftdkksfkly.tveiknekkkkkvkktvdilaf

LAWPDHCVPSDPNLFLEF
 |||||  | ...  |. 
sawpdhGapkeaytaldi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 721-829 3.4e-11 37.7 In-house 40-148 (255) alignment 
Range on Protein: 721-829
Range on HMM: 40-148/255.0
TTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFL
|   |.....|  .. .|||.   | |..||..|.|.  .| .  .  .| .     |     .     | .| . . ..| .|  |...  | ...  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

EFTERVRAA
.    || .
nilkvvrds
0048076 (Phosphotyrosine protein) phosphatases II 794-955 3.9e-23 77.1 In-house 42-139 (145) alignment 
Range on Protein: 794-955
Range on HMM: 42-139/145.0
HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNP
 . |.. . .|| ||||.||....|.||| | ...|...                                                           . 
llerlgiqylylpwpDhgvpdllellleflefieealke...........................................................gg

PVIVHCSAGIGRTGVLILMDtalaLMEAREpVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
||.||||||.||||.|....    ||  .  | . .... .| || ..|.|..|.||..|..
pvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 795-953 1.3e-21 72.2 In-house 45-139 (144) alignment 
Range on Protein: 795-953
Range on HMM: 45-139/144.0
EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAArnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPP
. |.... ..| ||||.||....|.||| | ...|                                                            . . |
leregiqylhlpwpDhgvpdllellleflefieea...........................................................leeggp

VIVHCSAGIGRTGVLILMDtalaLMEAREpVYPLDIVRTMRDQRACMVQNVSQYRFVCE
|.||||||.||||.|....    ||  .  . . .... .| .| ..|.| .|.||..|
vlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
PTPc_DSPc_SM00012 799-955 8.4e-28 92.0 In-house 2-103 (105) alignment 
Range on Protein: 799-955
Range on HMM: 2-103/105.0
IHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNPPVIVH
..|..|..||||.||.... .||. . |.  .|                                                            ..||.||
vkhyhytgwpdhgvPeesdsilellravkknknkses........................................................skpvvVh

CSAGIGRTGVLILMDTALALMEAR-EPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
||||.||||.....|..|  .|.. . |  ..||. .|.||. |||.  || |.....
CsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_PTPRG_pd Subfamily PTPRG 871-957 7.8e-15 49.1 In-house 196-285 (563) alignment 
Range on Protein: 871-957
Range on HMM: 196-285/563.0
GATPEDETPVSTSVHQCISAANP---PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 ..|| ..|| . |..   | .    |..||||||.||||..| .|| |  ..... |  .......| ||  .||.  || |. . .  
hgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
PTEN_1 873-938 2e-06 22.7 In-house 109-171 (196) alignment 
Range on Protein: 873-938
Range on HMM: 109-171/196.0
TPEDETPVSTSVHQCISAANP--PVIVHCSAGIGRTGVLILMdtalALMEAREpVYPLDIVRTMRDQR
. .    .  |..........   |.||| ||.||.|... .     ||...    . . .. .|..|
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgk.ltadeAlelvrekR
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 874-952 1.5e-09 32.2 In-house 183-263 (285) alignment 
Range on Protein: 874-952
Range on HMM: 183-263/285.0
PEDETPVSTsVHQCI---SAANPPVIVHCSAGIGRTGVLILMDTALA-LMEaREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
|||  |.   ... .      . |. ||||||.|||  .. .| |   .||    .  ||||| ||  |   ||.  |. |. 
pedarpmie.lykwvkkvnpkekpicvhcsagvgrtatfvgidyatirime.npniemldivremramrfqavqshmqflfly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 879-962 8.7e-09 29.9 In-house 178-262 (290) alignment 
Range on Protein: 879-962
Range on HMM: 178-262/290.0
PVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALME-AREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKI
 . .|. | . | . ||||||  || |  .|  .. .  ..   .. |   |.. ..| ||| ....  .. ||   |    ...
ktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaiev
0051429 (Phosphotyrosine protein) phosphatases II 881-962 1.7e-19 66.0 In-house 140-228 (272) alignment 
Range on Protein: 881-962
Range on HMM: 140-228/272.0
STSVHQCISAaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVY--------PLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKI
  .. . . . . ||.||||||..|||......  |. ...   |         ....|. .|.||...||.  ||.|..|.. ......
llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 882-961 5.2e-15 50.4 In-house 208-290 (325) alignment 
Range on Protein: 882-961
Range on HMM: 208-290/325.0
TSVHQCISA---ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
  |.... |   |  |..||||||.|||||.| . .||| .     |  .. |. .| .|  ||. | || .. |..  ||| 
kavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
0046846 (Phosphotyrosine protein) phosphatases II 883-956 2.4e-18 62.0 In-house 101-170 (176) alignment 
Range on Protein: 883-956
Range on HMM: 101-170/176.0
SVHQCISAaNPPVIVHCSAGIGRTGVLILMDtalaLMEAREPVYPLDIVRTMRDQRA-CMVQNVSQYRFVCECIC
 ....... . ||.|||||||||||.|....    |.| .  . ........|.||  ..||. .||||. |...
firealke.ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_PTPRD_pd Subfamily PTPRD 883-958 3.7e-18 60.5 In-house 205-280 (564) alignment 
Range on Protein: 883-958
Range on HMM: 205-280/564.0
SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 |... .  . |..||||||.||||. | .|  |  ... . |    .|...| ||  |||. .|| |. | |  |
kvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
subfamily_PTPN6_pd Subfamily PTPN6 883-965 3.4e-17 57.4 In-house 218-302 (306) alignment 
Range on Protein: 883-965
Range on HMM: 218-302/306.0
SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDI---VRTMRDQRACMVQNVSQYRFVCECIcAAYMKISRS
  ... .| . |..||||||||||| .|..|. | |.| .   ...||   |...|.||  .||  .||.|| . | ..|.. ...
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyietkkk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 883-963 7e-10 33.1 In-house 217-296 (301) alignment 
Range on Protein: 883-963
Range on HMM: 217-296/301.0
SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIcAAYMKIS
 .|.  .    ||.||||....|.|| . .. .|    |   |   ......| ..  .|.   || .. . |   |... 
vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmylqln
DSPc Dual specificity phosphatase, catalytic domain 883-953 8.1e-06 20.7 Pfam-A 65-129 (133) alignment 
Range on Protein: 883-953
Range on HMM: 65-129/133.0
SVHQCiSAANPPVIVHCSAGIGRTGVLIL---MDT-ALALMEAREPVypldivrtmRDQRACMVQNVSQYRFVCE
 ....  . .  |.||| ||| |.. ||.   |.|  | | || | |         ...| ....|... | ..|
fieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv.........kerrskispnagflrqLle
DSPc Dual specificity phosphatase, catalytic domain 883-953 8.1e-06 20.7 In-house 65-129 (133) alignment 
Range on Protein: 883-953
Range on HMM: 65-129/133.0
SVHQCiSAANPPVIVHCSAGIGRTGVLIL---MDT-ALALMEAREPVypldivrtmRDQRACMVQNVSQYRFVCE
 ....  . .  |.||| ||| |.. ||.   |.|  | | || | |         ...| ....|... | ..|
fieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv.........kerrskispnagflrqLle
subfamily_PTPRB_pd Subfamily PTPRB 884-961 6.7e-21 69.6 In-house 208-287 (293) alignment 
Range on Protein: 884-961
Range on HMM: 208-287/293.0
VHQCI--SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
|.. |  .|.. |..||||||.||||..| .|. |  .| .. |  . ||  .| .|...||...|| |. .|. .  .|
vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 884-957 1.7e-17 58.4 In-house 204-277 (288) alignment 
Range on Protein: 884-957
Range on HMM: 204-277/288.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
|..  .|   |.|||||||.||||. | .|...  .|. . .  ...|  .| ||| .||...|| |. |..  
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0049260 (Phosphotyrosine protein) phosphatases II 884-952 2.7e-17 58.3 In-house 81-143 (152) alignment 
Range on Protein: 884-952
Range on HMM: 81-143/152.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALalmearEPVYPLDIVRTMRDQRACMVQNVSQYRFVC
.....   . ||.||||||.||||.|....  |        | ....|. .| .| ..|.| .|.||. 
ieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPRN_pd Subfamily PTPRN 884-956 1.7e-12 41.6 In-house 216-289 (297) alignment 
Range on Protein: 884-956
Range on HMM: 216-289/297.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEarEPVYPLDIVRT---MRDQRACMVQNVSQYRFVCECIC
| ..      |..||||.| ||||| ||.|  |. .     |  .||. |   .||||. .|.  .|..|.  ...
vnksyrGrscpivvhcsdGaGrtGvyilidlvlnrll..kGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 884-961 3.3e-10 33.9 In-house 210-286 (302) alignment 
Range on Protein: 884-961
Range on HMM: 210-286/302.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIcAAYMK
|..  . |. ....    |.|| |... . .|.  ... . .   .||...| ||...|....|| ..  .. . |.|
vfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial.llyik
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 884-961 1.6e-09 31.7 In-house 214-290 (302) alignment 
Range on Protein: 884-961
Range on HMM: 214-290/302.0
VHQCISAaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
.. | |     |.||||||.|||| |. .   . |   ..    |.||  .|. |   ||. .|  ..  |.  . |.
lkfcesy.kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 884-954 1.9e-06 21.7 In-house 192-264 (281) alignment 
Range on Protein: 884-954
Range on HMM: 192-264/281.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL-DIVRTMR-DQRACMVQNVSQYRFVCEC
. . | |   | ..|||||.||.| |. .. ||  . ..  .  . .||  .|   ||. || . || .. . 
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkv
subfamily_PTPN12_pd Subfamily PTPN12 885-958 1.4e-17 58.5 In-house 200-276 (290) alignment 
Range on Protein: 885-958
Range on HMM: 200-276/290.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREP---VYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
..  .. . |..||||||.||||..| .| .  |..|.     .   |.|...| |||..||   ||..| ...   
relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Ptp69D_pd Subfamily Ptp69D 885-960 1.9e-14 48.5 In-house 212-287 (307) alignment 
Range on Protein: 885-960
Range on HMM: 212-287/307.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYM
..  .  . |..|||||| ||.|... .|  |  ..| . |   ..|. .| ||  .||.  || |.   .    .
relyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 885-959 3.8e-13 44.0 In-house 205-279 (315) alignment 
Range on Protein: 885-959
Range on HMM: 205-279/315.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
.|   ..  ...||||||.|||| .| .|. |  .|| . .   .... .|..|  ||| . ||.|. . .  ..
kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 885-959 1.3e-12 42.0 In-house 214-289 (305) alignment 
Range on Protein: 885-959
Range on HMM: 214-289/305.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL-DIVRTMRDQRACMVQNVSQYRFVCECICAAY
  .|  .. |..||||||||||| .. ..  |  .    |. |. ..|...|||||  .||  || |.   .   .
lsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_PTPRA_pd Subfamily PTPRA 886-959 5.2e-17 56.7 In-house 222-295 (330) alignment 
Range on Protein: 886-959
Range on HMM: 222-295/330.0
QCISA-ANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
..    |. |..||||||.|||| .| .|. |. ..| . |   ..|. .| ||. |||   || |. . .   |
klnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 886-956 4.5e-08 27.5 In-house 198-268 (288) alignment 
Range on Protein: 886-956
Range on HMM: 198-268/288.0
QCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
. . . . |..||.|||.|||| |||.  ||  .   . .    ..  .|..|   .|   || .|  |. 
evlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_PTPN1_pd Subfamily PTPN1 887-966 5.9e-14 46.5 In-house 196-278 (290) alignment 
Range on Protein: 887-966
Range on HMM: 196-278/290.0
CISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVR---TMRDQRACMVQNVSQYRFVCECICAAYMKISRSS
..|    |...||||||||.| ..|.|| |.|.|... .  .|| .    .| .|  ..|   | ||    |     .| ..|
slssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgds
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 887-957 2.7e-12 41.3 In-house 187-257 (267) alignment 
Range on Protein: 887-957
Range on HMM: 187-257/267.0
CISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 .  .|.|..|.||.|.||.| .. .|. |  .   . .   | .| .|.||  .|.   .| .. | .. 
qlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN13_pd Subfamily PTPN13 888-957 2.2e-19 64.8 In-house 198-267 (273) alignment 
Range on Protein: 888-957
Range on HMM: 198-267/273.0
ISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
.   . |..|||||||||.|.|| .|..| |.|  ...   .|||..|.||  .||   || || . |  
lqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 888-958 3.5e-16 54.2 In-house 212-283 (297) alignment 
Range on Protein: 888-958
Range on HMM: 212-283/297.0
ISAANP-PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 |  .  |..|||.||.||||||. .|  .| ..  . |  ...|. .|..|  .||   ||.|| . .  |
fsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 888-955 7.7e-12 39.4 In-house 212-279 (290) alignment 
Range on Protein: 888-955
Range on HMM: 212-279/290.0
ISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
.  |. ||.||||||||||| .. ....| ..     . .||.||..|. |.  ||   ||  . | .
lrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_PTPN14_pd Subfamily PTPN14 889-963 1.4e-19 65.2 In-house 226-299 (300) alignment 
Range on Protein: 889-963
Range on HMM: 226-299/300.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICaAYMKIS
  ..|||.||||||.|||||||| |  .| .|  | .    .....| ||  .||...||.|| . .   |.| |
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli.kylkns
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 889-959 2e-17 58.3 In-house 204-276 (281) alignment 
Range on Protein: 889-959
Range on HMM: 204-276/281.0
S-AANPPVIVHCSAGIGRTGVLILMDTALALMEA-REPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
.   . |...|||||.||||. | .|...  .|| .|.. . ..|. .| .|  ||| | ||.||   .  | 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 889-958 8e-17 56.3 In-house 210-279 (318) alignment 
Range on Protein: 889-958
Range on HMM: 210-279/318.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
.. . |..||||||.||||| | .|. |  ..| . |  ...|...|.||  |||  .|| |. . .  |
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_PTPN9_pd Subfamily PTPN9 889-955 1.3e-16 55.5 In-house 220-286 (297) alignment 
Range on Protein: 889-955
Range on HMM: 220-286/297.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
 . .||..||||||||||| .| .| .|. .|  . |   . |...| ||| ..|   || |   ..
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 889-958 3.1e-13 44.6 In-house 220-289 (298) alignment 
Range on Protein: 889-958
Range on HMM: 220-289/298.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 | | ||||.||||.||.|  | .|. |  ... . |  ...|...| .|. .||  .|| |. | .  |
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 889-958 2.2e-11 37.8 In-house 124-193 (440) alignment 
Range on Protein: 889-958
Range on HMM: 124-193/440.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 |.| |..|||||| |||||.| .|. |   .  . .  . .. .||..|  |||   || || |..  .
kagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavleg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 889-956 2.9e-11 37.7 In-house 259-341 (350) alignment 
Range on Protein: 889-956
Range on HMM: 259-341/350.0
SAANPPVIVHCSAGIGRTGVLILMDTALA----LMEAREPVYPL-----------DIVRTMRDQRACMVQNVSQYRFVCECIC
.|  .|..||||||.||||.|. .|  |     | . ..    |            ||  .| ||  ||||. |. |. |.. 
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 889-952 4.2e-08 28.6 In-house 111-170 (194) alignment 
Range on Protein: 889-952
Range on HMM: 111-170/194.0
SA-ANPPVIVHCSAGIGRTGVLIlmdtALALMEARePVYPLDIVRTMRDQRACMVQNVSQYRFVC
.. ..  | ||| ||.||||.|.    | .|.. .    . . ....|. |  ...|..... ..
nedpggvvaVHCkaGlgRtGtlv....aaYLiyrl.gmsaeeAialfrekRpgaipnqdyleall
subfamily_egg_pd Subfamily egg 889-966 2.6e-06 21.3 In-house 198-277 (307) alignment 
Range on Protein: 889-966
Range on HMM: 198-277/307.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMeAREPVYPLDIVRT---MRDQRACMVQNVSQYRFVCECICAAYMKISRSS
  .  ||.|..  |. ....|. ...||  .  | |..   . |.   .| .|   |. | .| ||   .   .  .  |.
rnlskpvvvqdilGvskaatlvaieiallsl.lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 890-956 1.4e-19 65.1 In-house 196-261 (270) alignment 
Range on Protein: 890-956
Range on HMM: 196-261/270.0
AANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
 |. |..||||||.||||.||..|.|. |.| .. | .| |.. .| .|  .|| . ||.|. . . 
kae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPRK_pd Subfamily PTPRK 890-958 3.5e-14 47.3 In-house 208-276 (314) alignment 
Range on Protein: 890-958
Range on HMM: 208-276/314.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
  . ...|||||| ||||. | .|. | ..| .. |    .|.|.|...  ||.   ||.|. . |  |
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 890-960 8.3e-14 46.1 In-house 214-284 (290) alignment 
Range on Protein: 890-960
Range on HMM: 214-284/290.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYM
  | ...||||...||..|.. ..|..  ..    .  .......| |.  .|| | ||..... .  .  
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPN23_pd Subfamily PTPN23 890-957 1e-13 45.8 In-house 210-278 (288) alignment 
Range on Protein: 890-957
Range on HMM: 210-278/288.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP-LDIVRTMRDQRACMVQNVSQYRFVCECICA
 .. |..||||||.|||||. |. .|.. .|... .   ...|...| ||  |||...|..|. | .  
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 890-958 9.5e-13 42.9 In-house 173-241 (250) alignment 
Range on Protein: 890-958
Range on HMM: 173-241/250.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
| | ||||.||||.||.|  | .|. |  ..  . |   ......| .|  .|.  .|| || | |  |
agnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 890-957 1.5e-12 42.1 In-house 209-276 (287) alignment 
Range on Protein: 890-957
Range on HMM: 209-276/287.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 .| ...||||...||..... ..|..   .    .  ..... .| |.  .|| |.||.|... . .
rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 890-957 5.7e-10 33.4 In-house 207-274 (312) alignment 
Range on Protein: 890-957
Range on HMM: 207-274/312.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
  . ||| |||||.|||| |.|... .| .         |.   .| .||  |. . || ..  |.  
kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 890-956 1.9e-09 31.3 In-house 263-341 (349) alignment 
Range on Protein: 890-956
Range on HMM: 263-341/349.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEARE-PVY-------PLD----IVRTMRDQRACMVQNVSQYRFVCECIC
.  ....|||||| ||||||. .|  |...|  .             |    || ..| ||  ||||..|. .. |.. 
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 890-955 1e-08 29.5 In-house 207-273 (307) alignment 
Range on Protein: 890-955
Range on HMM: 207-273/307.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP-LDIVRTMRDQRACMVQNVSQYRFVCECI
  . ||.||||||.||.| .. .      | | .      ..|. .|.||   .|.  || ..   .
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 890-951 1.6e-07 25.4 In-house 212-273 (301) alignment 
Range on Protein: 890-951
Range on HMM: 212-273/301.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFV
 .. |..|||||||||.  .|  .     .||   .   . .. .|..| . ||..||  ..
ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 891-958 1.4e-16 55.5 In-house 215-282 (319) alignment 
Range on Protein: 891-958
Range on HMM: 215-282/319.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 . |..||||||.||||  | .| .|  ..  . .    .|...| || .|||. .||.|. | . .|
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 891-955 4.7e-13 43.7 In-house 198-262 (283) alignment 
Range on Protein: 891-955
Range on HMM: 198-262/283.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
 . |..||||.|||||.|.| . ...  . .   |    .|. || ||  .||.  ||..| | .
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 891-955 3.1e-12 41.0 In-house 227-291 (297) alignment 
Range on Protein: 891-955
Range on HMM: 227-291/297.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
 | ...||||||.||.||..| |. || .  .       |.. .|.||| .|| . |. .. . .
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 891-952 3.2e-10 34.6 In-house 173-233 (239) alignment 
Range on Protein: 891-952
Range on HMM: 173-233/239.0
ANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
|  | ..|||||.|||| ....|. |   . .. |  .. |...|..|  |||   || |. 
ar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 891-952 4.3e-10 34.2 In-house 174-234 (239) alignment 
Range on Protein: 891-952
Range on HMM: 174-234/239.0
ANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
|  | ..|||||.|||| ....|. |   . .. |  .. |...|..|  |||   || |. 
ar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 891-957 2.2e-09 31.5 In-house 218-285 (305) alignment 
Range on Protein: 891-957
Range on HMM: 218-285/305.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL-DIVRTMRDQRACMVQNVSQYRFVCECICA
.  |..||||||||||| .....  |  . | . .     |.. .|.||   .|   || || . |  
skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 892-957 2.3e-15 51.7 In-house 224-289 (319) alignment 
Range on Protein: 892-957
Range on HMM: 224-289/319.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
. ...||||||.||||| | .|. |  |.  . |   ..|| .|.||  .||.. || |.   .  
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 892-955 3.1e-15 51.1 In-house 216-279 (305) alignment 
Range on Protein: 892-955
Range on HMM: 216-279/305.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
. |..||||||.||||| | .| ||  ... | |   ......| .|  |||.  || |. . .
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 892-958 3.6e-15 51.2 In-house 188-254 (284) alignment 
Range on Protein: 892-958
Range on HMM: 188-254/284.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
. ...||||||.||||| | .|. |  |.  . |   ..|| .|.||  .||.. || |.   .   
ranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 892-956 1.7e-13 45.1 In-house 210-274 (315) alignment 
Range on Protein: 892-956
Range on HMM: 210-274/315.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
. ...||||||.|||||.| .|  .| .. .. |  ...|...|..|  .||   .| |. . . 
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 892-955 3.2e-13 43.6 In-house 209-272 (515) alignment 
Range on Protein: 892-955
Range on HMM: 209-272/515.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
. |.|.|||||.|||||.| .|  .| ..  . |  ...|. .|..|  .||   || |. . .
thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_CG7180_pd Subfamily CG7180 892-961 5.4e-13 43.2 In-house 223-292 (296) alignment 
Range on Protein: 892-961
Range on HMM: 223-292/296.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
. ||.|..| | .|.|| . .| .| |.|  | |   . |.|.| .|  .|.|| .|... . .  |.. 
egPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 892-955 2.5e-09 31.7 In-house 172-235 (237) alignment 
Range on Protein: 892-955
Range on HMM: 172-235/237.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
  | |.|||||.||||.....|. |   . .. |   . | .. ..|  ..|   || |. . |
sgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 893-960 2.2e-14 47.9 In-house 211-278 (287) alignment 
Range on Protein: 893-960
Range on HMM: 211-278/287.0
PPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYM
 |..||...||||.|.|. . . .  .|    | .  .|  .| .||..|| | |.|...| . . | 
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 893-956 2.4e-13 44.3 In-house 213-276 (439) alignment 
Range on Protein: 893-956
Range on HMM: 213-276/439.0
PPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
 ||.||||||.|||| .| .| ||  . . . |    ||. .|.||  |||.. || |. ... 
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 894-955 2.1e-10 34.6 In-house 171-232 (392) alignment 
Range on Protein: 894-955
Range on HMM: 171-232/392.0
PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
|.|.|||||.|||||.| .|. .|  .    |  ...|  .| .|  |||   || |.  ..
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_PTPDC1_pd Subfamily PTPDC1 894-953 3.3e-06 21.7 In-house 116-170 (182) alignment 
Range on Protein: 894-953
Range on HMM: 116-170/182.0
PVIVHCSAGIGRTGVLIlmdtALALMEArEPVYPLDIVRTMRDQRACMVQNVSQYRFVCE
 | ||| || |||||||    |  |. | . . . . ....|..|.  .|  .| ..| |
kvavhChaGlGrtGvli....acylvya.krltaekaiklvrskrpksiqtreqvelvke
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 896-958 9.4e-08 26.4 In-house 2-64 (69) alignment 
Range on Protein: 896-958
Range on HMM: 2-64/69.0
IVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
.||||.| |||| .| .   .| . .   |  .. |. ||  |  || |  .| |. . .  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 896-958 1.1e-07 26.1 In-house 1-63 (69) alignment 
Range on Protein: 896-958
Range on HMM: 1-63/69.0
IVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
.||||.| |||| .| .   .| . .   |  .. |. ||  |  || |  .| |. . .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea