Gene Ptpmeg in Drosophila melanogaster

Synonym: CG1228, Dmel\CG1228, MEG1, Meg, PTP-meg, anon-WO0118547.211, dMEG1, dPtpmeg, ptmpeg, ptpmeg, scc, Dmel_CG1228, Ptpmeg

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP043_AA protein Get Run
DmelP043_AA_629-960 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 38-121 1.6e-20 63.2 Pfam-A 1-80 (80) alignment
Range on Protein: 38-121
Range on HMM: 1-80/80.0
VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSvsldNDAVPLLEFRVKFFV
| .||. .... ......|..||..|.. |.|.| .|||| | ..  .  .|.|..|. ..|...    ...  .| .||||.|
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgve....egkpttlllrvkfyv

FERM_M FERM central domain 123-232 2.5e-21 66.3 Pfam-A 1-126 (126) alignment
Range on Protein: 123-232
Range on HMM: 1-126/126.0
DPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFN-ALEHQPGY-LSGMQL------LC--------DQTTEAERKVGELHKLHR
||.....| .....|.|.|...|...|.|. ..  |||.. .| |.||.. . ... .. .. ..       |          .. . |... | || ..
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GQLPADAEYNYLEHAKRLELYGIDLH
|. .|.|...||. |..|. ||..|.
glslaeaklkylqaaqslpdyGvslF

FERM_C FERM C-terminal PH-like domain 236-324 9.3e-26 80.2 Pfam-A 1-88 (90) alignment
Range on Protein: 236-324
Range on HMM: 1-88/90.0
DSNGKELQLGVSAVGLLVFQHSLRV--NTFSWSKMVKVSFKRKDFFIQLRRepsENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPH
...|..| |||.| |||....  ..  ..|.||.. |.|||.| |.|.||    |.....| | .|... .| |.|.|.|.|..|| .|..
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrrkv

FA FERM adjacent (FA) 327-371 6.1e-20 59.8 Pfam-A 1-43 (47) alignment
Range on Protein: 327-371
Range on HMM: 1-43/47.0
SRFLniSLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLL
|.|.  |||||| ||||||.|...||...|| .. | |||||| |
skff..slGSkFRYSGRTekQvieesreigrkppsfeRspskryl

PDZ PDZ domain (Also known as DHR or GLGF) 505-588 5.5e-19 58.3 Pfam-A 2-80 (81) alignment
Range on Protein: 505-588
Range on HMM: 2-80/81.0
IRLQADEQGRYGFNVKGGVDLS-LPVQVSKVVPHtPADRCTPrVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHqasgELLLTV
..|.....|. ||..||| | .  .. ||.|||  .|. . . ..||| .| .||.|| ...|...|..|....     |. ||.
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg....evtLti

subfamily_PTPN3_pd Subfamily PTPN3 627-962 8.5e-143 469.3 In-house 2-278 (280) alignment
Range on Protein: 627-962
Range on HMM: 2-278/280.0
TQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTgDYINANYVNMEIPG-GAVNRYIATQGPLASTTTDF
..|||||..||.|||.|||.| .|||.|.|||..||||.|..|||||||.|||.|||.|..| | |||||||||||||. |.||||||||||||.|.|||
resllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdf

WRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAeGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFT
|.||....|.|.|||||..|.||.||||||| |..||... .|||.| .|  ||| |.|.||.|||||.  |.|.|...||||||||.||.|.. ||||.
WqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv

ERVRAARnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEARE
||||..|                                                          |... ||.|||||||||||||||..|||||.||.|
ervrklr..........................................................sgkeePvvvhCsaGigrtGvlilletalalieaae

PVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKI
||||||||||||||||..||..|||.||||.|...|..|
pvypldivrtmrdqramlvqtasqykfvCeailkvyeei

0050432 (Phosphotyrosine protein) phosphatases II 630-961 6.9e-86 283.7 In-house 32-301 (308) alignment
Range on Protein: 630-961
Range on HMM: 32-301/308.0
LLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLvnSLTGDYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMV
| || . | .| | ...| .... |.| .. |..|.| .||||.|| ||| .|| |  . . |||||.||.. .  .  ...||||||| .|. ||||||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys.sklprkfIatqgPlpntvedFwrmv

QQESSHLLVMLTTVMESGRQKCHQYWPVTGE-ELQLAEGFSVRCLSEKPdeTGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
 .. ... ||||. .| ||.||.|||| . . . .  ..|.|..|||.    .... |.. |..  . | |...|..|..||||.||..|. .|.| |.|
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RaarnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhQCIsaANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVY
|                                                          ...   ..|..||||||.||||..|..|..| ..|.   | 
r..........................................................ksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvd

PLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
....|...| ||..|||...||.|......  ...
vfeavkklReqRpgmvqtpeqylflyralleylkl

0047943 (Phosphotyrosine protein) phosphatases II 632-956 5.2e-81 267.4 In-house 4-269 (273) alignment
Range on Protein: 632-956
Range on HMM: 4-269/273.0
LLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLvNSLTGDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQ
|| . | .. ||...||...  |.| .. |..|.|  ||||.|| ||| .|| | .. . |||||.||..       ...||||||| .|. |||||| .
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdg...ynlkrkfiatqgPlpntvedfwrmvwe

ESSHLLVMLTTVMESGRQKCHQYWPVTGEE-LQLAEGFSVRCLSEKPdeTGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
. ....||||...| ||.||.|||| .|.|  .  . |.|..|||.    .... |.. |..   .| |...|..|. ||||.||.... .||| | || 
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

ARNrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL
|..                                                         .  |.||.||||||.||||..|..|..| ..|..  | .|
ale........................................................alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvl

DIVRTMRDQRACMVQNVSQYRFVCECIC
..|. .|.|| .|||...||||..|...
eavkllrsqRpgmvqtpeqyrflyeall

0036941 (Phosphotyrosine protein) phosphatases II 633-961 2.1e-82 272.0 In-house 6-279 (297) alignment
Range on Protein: 633-961
Range on HMM: 6-279/297.0
LSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLvNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQE
| . | .  || ..| ...  ..  .. |..|.| .||||.|| ||| ||| | ..   |||||.||..    .  ...||||||| .|. |||||| ..
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgy...dlkrkfIatqgPlpntvedFWrmvweq

SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
 .. .||||...| ||.||.|||| . .| .  ..|.|..||.. .. .... |.. ..|  . |.|...|..|. ||||.||..|. .|.| |.|| ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

NRTllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisAANPPVIVHCSAGIGRTGVLILMDTALALME---AREPVYP
. .                                                          ..||.||||||.||.|..|..|..| ..|    .. | .
kll........................................................psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdi

LDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
|..|...|.||...||...||||..|..   ..|
leavkklReqRpgavqtleqyrflyeallellkk

subfamily_PTPN14_pd Subfamily PTPN14 633-833 5.4e-45 148.7 In-house 16-219 (300) alignment
Range on Protein: 633-833
Range on HMM: 16-219/300.0
LSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL--TGDYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMVQ
|   | .| . ..|| . .|. |  .. |. | ||.|||..|. ||. .|| |. .   . .||||  ... . ||.   ||..||||  | .|||.|| 
lekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv.ggkersyivaqgPleltvqdfWqmvW

QESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
..  .|.||||   |.|..|...|.| .... . .|    .  ..  ....|.. . . ||    .|.| ..|.||  |||| ||.|.. ||.. |.|..
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

ARNRT
 |..|
vrrkt

0039614 (Phosphotyrosine protein) phosphatases II 636-958 2e-79 262.4 In-house 28-288 (297) alignment
Range on Protein: 636-958
Range on HMM: 28-288/297.0
GLASGALLAQYELMYRKNPDlaITEARKPANAPKNRYRDISPYDCTRVSLVNS----LTGDYINANYVnmEIPGGAVNRYIATQGPLASTTTDFWRMVQQ
 . .. ||...| ... .||  ...|..|.| .||||.|| ||| .|| |       |  |||||.||  . .    ...||||||| .|. ||||||..
ansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedFwrmvwe

ESSHLLVMLTTVMESGRqKCHQYWPVTGEelqLAEGFSVRCLSEKPdeTGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
. .. .||||. .| || ||.|||| .|.     ..|.|..|...    . .. |.. .... | |...|.||. ||||.||....|.||| | || |..
qgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

RtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIV
.                                                        .  . ||.||||||.||||..|.....| ..| .  | .|..|
e........................................................lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleav

RTMRDQRACMVQNVSQYRFVCECICAA
...| || ..||. |||||......  
kelreqRpgavqtpsqyrflydallel

0040438 (Phosphotyrosine protein) phosphatases II 640-961 2.1e-80 265.6 In-house 18-278 (317) alignment
Range on Protein: 640-961
Range on HMM: 18-278/317.0
GALLAQYELMYRKNPDlAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT---GDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQESSHL
.||| ..| ... ..|  ...|..|.| .||||.|| ||| .|| | .       |||||.||..       ...||||||| .|. ||||||... ...
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdg...pnlkrkfIatqgPlpntvedFwrmvweqgvtv

LVMLTTVMESGRQKCHQYWPVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtl
.||||. .| ||.||.||||   .| .  ..|.|..|||.    .... |.. ..|  . |.|...|..|..||||.||..|.|.|.| |.||.|.    
ivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal....

lqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTM
                                                      .  . ||.||||||.||||..|.....| ..| .. | . ..|...
......................................................edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

RDQRACMVQNVSQYRFVCECICAAYMK
| ||...||. .||||......  ...
reqRpgavqtpeqyrflydalleylkr

0043336 (Phosphotyrosine protein) phosphatases II 640-956 2.7e-76 252.0 In-house 20-274 (278) alignment
Range on Protein: 640-956
Range on HMM: 20-274/278.0
GALLAQYELMYRKNPdLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQESSHL
 .||...| ... ..   .. |..|.| .||||.|| ||| .|| | .    |  |||||.||..       ...||||||| .|. ||||||... .. 
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg...ynvprkfiatqgPlpetvedFwrmvwelgvtt

LVMLTTVMESGRQKCHQYWPvtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtl
.||||. .| ||.||.||||   .. .  ..|.|..|.|.    . .. | . ..   ..| |...|..||.||||.||....|.|.| ..|| |.    
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal....

lqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTM
                                                      .  | ||.||||||.||||..|.....| ..| .  | ....|...
......................................................edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RDQRACMVQNVSQYRFVCECIC
| ||...||. |||||..|...
reqRpgavqtpsqyrflyeall

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 640-760 1.7e-22 74.4 In-house 27-145 (310) alignment
Range on Protein: 640-760
Range on HMM: 27-145/310.0
GALLAQYELMYRKNpDLAITEARKPANAPKNRYRDISPYDCTRVSLV--NSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLL
  |  ||  .  |. | ..|      .  |||| |.   | .|| |   .|  .||| ||||. .      . .| .||||  |  |||||. || .  .
eglvkqyrkldakq.dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny...lrstficsqgplqhtiidfwrmifqeraesi

VMLTTVMESGRQKCHQYWPVTGE
..|  |.| || ||  |||  | 
lllckvgeegrpkcvgywpslgv

0051299 (Phosphotyrosine protein) phosphatases II 641-958 1.8e-82 272.3 In-house 24-285 (288) alignment
Range on Protein: 641-958
Range on HMM: 24-285/288.0
ALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMeipGGAVNRYIATQGPLASTTTDFWRMVQQESSHLL
 ||...| .....||| .. |..|.| .||||.|| ||| .|| | .     ..|||||.|...       ...||||||| .|. |||||| .. ... 
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg...ynlkrkfIatqgPlpntvedFWrmvweqnvrvI

VMLTTVMESGRQKCHQYWPVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK------DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRaarn
||||...| ||.||.||||   .. .  . ..|..|||.    .... |.. ..       ..| |...|..|..||||.||..|.|.|.| ..||    
vmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr....

rtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIV
                                                      ..... ..||.||||||.||||..|..|..| ..|... | .|..|
......................................................kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

RTMRDQRACMVQNVSQYRFVCECICAA
...| || .|||...|||||.|... .
krlreqRpgmvqtpeqyrfvyealley

0045450 (Phosphotyrosine protein) phosphatases II 641-957 7.4e-78 257.7 In-house 28-302 (307) alignment
Range on Protein: 641-957
Range on HMM: 28-302/307.0
ALLAQYELMYRKNP--DLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT----GDYINANYVNMEIP-----GGAVNRYIATQGPLASTTTDFWRMV
 ||...| ... ..     ...|..|.| .||||.|| ||| ||| | .       .|||||.||.. ..         ...||||||| .|  |||||.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

QQESSHLLVMLTTVMESGRQKCHQYWPVTgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK---DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
... ....||||. .| ||.||.|||| . .| .  . | |..|||.    .... | . ..    ..| |...|..|..||||.||.... .|.| |.|
weqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RAARNRtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREP--
|.|...                                                        .  . ||.||||||.||||..|.....| ..|...   
rkalee........................................................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtll

-VYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 | .|..|...|.|| ..||| .||||..|... 
dvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 641-832 7.5e-36 118.8 In-house 23-213 (305) alignment
Range on Protein: 641-832
Range on HMM: 23-213/305.0
ALLAQYELMYRKNPDLAITeaRKPANAPKNRYRDISPYDCTRVSLVNSLTG---DYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLL
.| |||...|...  . ..  .| ||. |||...| ..|  |. | .. .    |||||.||.        ..||..|||| .| .||||.. .|  . .
gleaqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy...krkkkyivaqgPlkntvadfWrliveekvsti

VMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKpdETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
|||| ..| |..||.|||| .  | .  . |||   |||  ..  .. |.. .     ..|.| . ..|   |||| ||  .  .|.. .||. ....
vmltklveggkdkCrqYWpesktekkefgefsvelksek..tasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 641-828 3.6e-30 100.0 In-house 17-207 (307) alignment
Range on Protein: 641-828
Range on HMM: 17-207/307.0
ALLAQYELMYRKNPDLAITEARKpANAPKNRYRDISPYDCTRVSL-VNSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
||  ... . .|.|.   .|| . ||. ||||.|.   | .|. . .. |. ||| |||. . |     ...|..|||| .|  .|| |. ||    ..|
alvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkfdglasdyihanylgiai...kpkkficaqgplentqysfwamaiqekvesvim

LTTVMESGRQKCHQYWPVT-GEELQLAE---GFSVRCLSEK---PDETGSFVfREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
|  |.| .. ||.||||.  |..|  .|     ||  |  |   |||    |  .. ..  .. | |.|.|.  |||. ||      ... | || 
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry

0046845 (Phosphotyrosine protein) phosphatases II 642-961 2.2e-80 265.4 In-house 2-276 (284) alignment
Range on Protein: 642-961
Range on HMM: 2-276/284.0
LLAQYELMYRKNPDL--AITEARKPANAPKNRYRDISPYDCTRVSLVNSLT----GDYINANYVNMEIPG--GAVNRYIATQGPLASTTTDFWRMVQQES
| ...| ... ...|   .. |..|.|  ||||.|| ||| .|| | .       .|||||.||..   .     ...||||||| .|. |||||| .. 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SHLLVMLTTVMESGRQKCHQYWPVTgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
....||||. .| ||.||.|||| . .| .  ..|.|..|||.    .... |.. |..   . | |...|..|..||||.||..|. .||| . || ..
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

NRTLLQeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaanPPVIVHCSAGIGRTGVLILMDTALALMEARE---PVYP
...  .                                                        .|..||||||.||||..|..|..| ..|...    | .
enlpgg........................................................gpivVHCsaGvgRtGtfialdllleqlekeglllgvdv

LDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
|..|. .|.|| .|||...|||||.|... ....
leavkrlreqRpgmvqtleqyrfvyealleylkl

0045098 (Phosphotyrosine protein) phosphatases II 642-959 5.5e-75 247.6 In-house 9-272 (278) alignment
Range on Protein: 642-959
Range on HMM: 9-272/278.0
LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSlvnsltgDYINANYVNMEiPggavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLT
|| ..|  .. ..   ||.| .. |..||||.|| ||| .||        |||||.|...  |    ...||||||| ||. |||||.... .. .||||
lllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy.p....kkfIatqgPlpstvadfwrmlwelgitvivmlt

TVMESGRQKCHQYWPvTgEELQLAEGFSVRCLSEKPDetGSFVFREFVLK------DKHEQRHIHHMQYLAWPDHCVPSDP--NLFLEFTERVRAARNRT
...| ||.||.||||   .. .  ..|.|..|||.    . .. | . .          |.|...|..|| ||||.|||.|  . |||..|..|.|... 
elvelgrekcaqywp.e.ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

LLQEIEESlkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqCISAANPPVIVHCSAGIGRTGVLILMDTALALMeaREPVYPLDIVRT
. . . .                                               .   . ||.||||||.||||.|..... | |.   . | .|..|..
aslllssl.............................................llldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavke

MRDQRAC-MVQNVSQYRFVCECICAAY
.| || . .||| .||||..|...  .
lrsqRpglavqnleqyrflyefllell

subfamily_PTPN9_pd Subfamily PTPN9 642-832 1.7e-43 143.7 In-house 18-208 (297) alignment
Range on Protein: 642-832
Range on HMM: 18-208/297.0
LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLV
|  .|. . ....   .. ....||  |||| |.  || ||| | .     . ||||||.|.        . .|||||||  |..|||||| ...   .|
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy...kqkkafiatqGplkktvsdfWrmvWeqevlviv

MLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKpdETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
| | |.| || || |||| . |. .    .||. .. .  |.  ...| ...|  ...|.|.. | |.|.|||. |||. . .|.. | || ..  
mttrvvergrlkcgqyWpleeessaefgdlsvsnveve..eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 642-824 2e-42 140.1 In-house 9-191 (297) alignment
Range on Protein: 642-824
Range on HMM: 9-191/297.0
LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTG-DYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
| |...|.....   . . |....   |||||||  .| ||| | .. |. |||||.|| .     |  .|| .|||| .|  |||..| ..    .||.
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpd.eeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE
. . | ||.||  ||| . .| . |  . |  ||.  ||    .. |. |  . |.|...|.|.|.|||| |||| .    |  
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa

subfamily_PTPRG_pd Subfamily PTPRG 642-832 1.3e-38 127.6 In-house 21-218 (563) alignment
Range on Protein: 642-832
Range on HMM: 21-218/563.0
LLAQYE-LMYRKN-PDLAITEARKPANAPKNRYRDISPYDCTRVSLVnSLTG-----DYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESS
. ...| |. . .  || .. ..|| |  |||| .| .|| .||.|  .|.|     |||||||..        . .|||||||..|. |||||. .. .
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvkls.plpgkkkklDYinAnyidGy...qkskafiatqgplkdtfddFWrmiWeqnv

HLLVMLTTVMESGRQKCHQYWPVtgEELQLAEGFSVRCLSEKPDET---GSFVFREFVLKDKHE---QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
...||.| . |.||.||..|||   .| .  . ..|.  .|.   .    ..| ... ||.|..   .... . .|  ||||.||. .   | | ..  |
aiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa

ARNR
|...
anka

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 642-822 1.2e-23 78.3 In-house 17-213 (301) alignment
Range on Protein: 642-822
Range on HMM: 17-213/301.0
LLAQYELMYRKNPDLAITEArKPANAPKNRYRDISPYDCTRVSLVNSLT-----GDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHL
. .||. ....... .. .  . .|.. ||...|..||  |. | .  .      .||||.|..        ...||.|||. .| .||||.. ||    
feeqykelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy...sekkkfiaaqgpmkktlvdfWrliwqekpvs

LVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEK--PD------------ETG-SFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLE
.||.|   |. ..||.|||| . .| .    |.|   .|.  ||             .. ... |.|  | ... ...  .|   ||.. |  .|.  |.
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

F
 
v

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 643-830 1.9e-43 143.7 In-house 23-208 (318) alignment
Range on Protein: 643-830
Range on HMM: 23-208/318.0
LAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
 ..|| . |..   . ... .|.|. |||| .| .|| ||| |    .. . |||||||..      . . |||.|.||. | .|||||| .  | ..||
seeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr...rkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTTVMESGRQKCHQYWPVTGEelQLAEGFSVRCLSEKpdETGSFVFREFVLKDK--HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|| ..|.|..|.|.|||  |   .  .   |   .|.  |....| ||| .. .  .|.|...  .| .|||. ||...  .|..  .|..| 
ltqeeergkakvhryWPskgs..rsygklvvelkeev..elsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq

subfamily_Ptp69D_pd Subfamily Ptp69D 643-829 1.3e-35 118.1 In-house 25-214 (307) alignment
Range on Protein: 643-829
Range on HMM: 25-214/307.0
LAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
.  || . ... |.  . . |  || |||| || ..| ||| | .   . . |||||....        ...|| |.|. .|  |||||. . ...|.||
akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik...gykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LTTVMESGRQKCHQYWPVTgEELQLAeGFSVRCLSEKpdETGSFVFREFVLKDKH-------EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
|. . |  |.||..|||.  .| |      |.. ||.  ... .. ||. .  |.       ..|..   .|..|.|  ||  ..  |.. |.||  
lsnlteknrkkcakYWpie.devqyg.dilvklvsee..khsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 643-830 1.6e-24 81.2 In-house 25-219 (305) alignment
Range on Protein: 643-830
Range on HMM: 25-219/305.0
LAQYELMYRKNpDLAITEA-RKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMeiPGgAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLT
 |..  | | | |.   .| ..  .| ||||.|.   |  || | ..   .|| ||||    |    .|.| || ||  | .||| |  |.  . . || 
raefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..pt.npkrfictqaplektcadfwymclqdkveaifmlc

TVMESGRQKCHQYWPVT-GEELQLAEG---FSVRCLSEKP----DETGS-FVFREFVLKDK-HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
 ..| | .||..|..   ...|.. |.    ||.. | .     ... .     ..|..   ...|.. |  .  |||  ||.  .  ||. |. |...
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk

DSPc_SM00195 644-959 1.2e-74 246.3 In-house 4-262 (263) alignment
Range on Protein: 644-959
Range on HMM: 4-262/263.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
...| . .....  .|||.|..|  ||||..| ||| ||| | ..    . |||||||....      ..|||||||| ||  |||||| .| ... |||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDEtGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTllqei
|  .|.|..||..||| . .. .  . .|| . ... ..  ... |.. |. .   |.| ....|| .|||| ||.... .||. . |.  ....     
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

eeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQR
                                                     ..|..||||||.||||.....|..|  .|. . |   .||. .|.||
.....................................................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

ACMVQNVSQYRFVCECICAAY
. |||.  ||.|..|.| ...
pgmvqtleqYlfiyeaileyi

PTPc_SM00194 644-959 1.2e-74 246.3 In-house 4-262 (263) alignment
Range on Protein: 644-959
Range on HMM: 4-262/263.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
...| . .....  .|||.|..|  ||||..| ||| ||| | ..    . |||||||....      ..|||||||| ||  |||||| .| ... |||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDEtGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTllqei
|  .|.|..||..||| . .. .  . .|| . ... ..  ... |.. |. .   |.| ....|| .|||| ||.... .||. . |.  ....     
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

eeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQR
                                                     ..|..||||||.||||.....|..|  .|. . |   .||. .|.||
.....................................................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

ACMVQNVSQYRFVCECICAAY
. |||.  ||.|..|.| ...
pgmvqtleqYlfiyeaileyi

subfamily_PTPRB_pd Subfamily PTPRB 644-833 9.2e-52 170.9 In-house 29-215 (293) alignment
Range on Protein: 644-833
Range on HMM: 29-215/293.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYvnmeIPGGA-VNRYIATQGPLASTTTDFWRMVQQESSHLLVM
 .|| .   . | |.. |....|. ||||..| ||| .|| |    .. . |||||||    |||    . .||||||| .|. |||||| .. |. .||
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTTVMESGRQKCHQYWPVTGEELQLAeGFSVRCLSEKpdETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRT
|| ..| |..||..||| . |. .     .|  ..|.  |.  .| ||. .. ..|.|.........|||| ||.... .|.|...|| | ..|
ltqlvekgkvkCeeYWPadeepvlyG.dikvtlvaee..eledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekt

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 644-832 7.5e-46 151.5 In-house 19-205 (281) alignment
Range on Protein: 644-832
Range on HMM: 19-205/281.0
AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVML
 .|| ..  . | . | .....|  ||||..|. || ||| .    .. . ||||||.|.        ..|||||||. .. ..||.|| ... ...||.
eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy...kgekeyiatqgPvPaslvafWqmvweqkvsaivmv

TTVMESGRQKCHQYWPVTGEELQLAEgFSVRCLSEkpDETGSFVFREFVL-KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
|  .|.|. |||.|||   .||.... . |. ..|   |. ... |.| | ... |.|......|.||||| ||.... .||| . |. ....
treieagklkChrYWPddnselkygd.vtvkstae..eekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltek

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 645-831 1.4e-46 153.8 In-house 26-209 (288) alignment
Range on Protein: 645-831
Range on HMM: 26-209/288.0
QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLT
.|. .   . . . | .|.. ||.|||||.| ||| .|| | .     . |||||.|.. |   .  ..|||||||||.|  |||..| .. .. .||||
eynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge...kkkkkyiatqgPladtvndfWelvyenktstivmlt

TVMESGRQKCHQYWPVTGEElQLAEGFSVRCLSEKpdETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
 ..| |..||..||| .... ..   . |  ...|  |...|| |.. |. |.....|...|||||||| || . . .||. . |  | .
elveggktkCeeYWPdadkp.knyGsvtvtlvesk..eledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 645-833 6.4e-31 102.4 In-house 25-210 (287) alignment
Range on Protein: 645-833
Range on HMM: 25-210/287.0
QYELMYR-KNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVnSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTV
|. .. . .. .  .| .  . | .|||...| ..|  || |      ||||| ...        ...|....|...|  .||......  . .|||.  
qftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgy...kekkafiiaesPmfntarnfWkliddrnvtaivmlcqe

MESGRQKCHQYWPVTGEeLQLAEgFSVRCLSEKpdETGSFVFREFVLKDKH---EQRHIHHMQYLAWPDHC-VPSDPNLFLEFTERVRAARNRT
.|. ...|.|||| .   . | | .... |.|.   . ... |.. .| |.   ......  |. .|...  |..    .| . |.... | |.
kendeevcyqyWpeeks.vvlGe.yniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 645-833 1e-29 98.3 In-house 25-215 (290) alignment
Range on Protein: 645-833
Range on HMM: 25-215/290.0
QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLV-----NSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVM
|.. .   . . ..| .  . | ..||...| .||  |. |      .  | .|||| |..        ..|||||||. .|  |||....||..  .||
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy...kekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTTVMESGRQKCHQYWPVTGEELqlAEGFSVRCLSEKPDEtgSFVFREFVLKDKHE---QRHIHHMQYLAWPDHC-VPSDPNLFLEFTERVRAARNRT
||...|.|..||.|||| .. .    . ||.. |.|.  .  ... |.. .|.|..   ...... |  .|...  |.      | ..|...  | |.
ltniieegkvkCqqYWpdsdtka..ygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

subfamily_CG7180_pd Subfamily CG7180 645-833 1.5e-24 81.2 In-house 18-217 (296) alignment
Range on Protein: 645-833
Range on HMM: 18-217/296.0
QYELMYRKNPDLAITEA---RKPANAPKNRYRDISPYDCTRVSLvNSLTG----DYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLL
.|.|.... | | | .     .  |  |||. .. ||| .|| | ..| |    ||||| ||.  .     . || |..|  .|  .|||.| .| .. .
eyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvL.ekldGeeksdYinavyvdsfl...kkkeyivteapkketvdefWrlvydeeisav

VMLTTVMESGRqKCHQYWPVTGeELQLAEGFsVRCLSEKpdETGSFVFREFVLKDK------------HEQRHIHHMQYLAWPD-HCVPSDPNLFLEFTE
|.|| ...  . ....||| .. . |  | | |  ..||  .   .. |.| |. |             |.| ....|.  |.  . ||.  | ..|. .
vvLtktfdfak.mypsywpnks.keqygeif.veiveek..qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

RVRAARNRT
|||  |...
rvrlwrekv

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 646-833 8.7e-41 135.0 In-house 29-214 (319) alignment
Range on Protein: 646-833
Range on HMM: 29-214/319.0
YELMYRKNPDlAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTT
..|.   ..|  ...| |. | .||||..| .|| ||| |    ..   |||||....        ...||||.||. |. |||||| .| |. .|||| 
fkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy...qerekfiatqaPlentiedfWrmvWeeessivvmltk

VMESGRQKCHQYWPVTgeElQLAEGFSVRCLsEKPDETGSFVFREFVLKDKHE---QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRT
. | .. |...||| .  .     |  .  | |. .|.  .. |.. |. | .    |.. | ||..|||| || .  . |.. .|.| .|..|
lveklkvklkkywpee..n.feeyGrlivtl.eeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

subfamily_PTPN12_pd Subfamily PTPN12 647-831 1e-45 150.9 In-house 21-204 (290) alignment
Range on Protein: 647-831
Range on HMM: 21-204/290.0
ELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT---GDYINANYVNMeiPGGaVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTV
.  |...     ....|. |  ||||.|| ||| .|| | .       ||||||...   . |   .|||.||||. | .|||||... . ...||.  .
sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..veg.kleyiaaqgPLpktlddfWrmiweknveivvmaCre

MESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGsFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
.| |..||..||| .|||    . |.| . .||  . . |. | . .. ..|.|... ..| ||||| ||| ..  ||..| ||  ..
velgkkkCerYWpeegeeelefgefevtleeekavddd.flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

subfamily_PTPN13_pd Subfamily PTPN13 649-829 1.2e-44 147.6 In-house 20-198 (273) alignment
Range on Protein: 649-829
Range on HMM: 20-198/273.0
MYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTgdYINANYVNMEIpGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGR
.    | .  ....| .|  |||||.. ||| ||| | .. .  ||||....... |    .|||.||||  |..|||.|| . ......|.|.  |.|.
lrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

QKCHQYWPVTG-EELQLAEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
 |||.|||..  ..|.. . . |. |     .  .|| |.. .||..  | |.. |... .|||| ||| .. .|.|  .||  
vkchrywPesknkklkvsnrlevellkv..qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

subfamily_PTPN1_pd Subfamily PTPN1 650-829 1.3e-47 157.0 In-house 16-194 (290) alignment
Range on Protein: 650-829
Range on HMM: 16-194/290.0
YRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTgDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ
 ..  |. ..||..|.| ..|||||.|||| .|. | .. . |||||. |..|    |  .|| |||||..|.. ||.|| .. |. .|||  |.| ...
rkeasdfptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvelee...akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCHQYWPVTGE--ELQLA-EGFSVRCLSEkpDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
||.||||   |  ||.|    ..|. .||  ...  .. | . |..   .| |.| |. |..|||  ||. |. ||.|  .|| .
kcaqywPqgeeekellledtklkvklise..erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres

subfamily_PTPRN_pd Subfamily PTPRN 650-827 3.7e-32 106.2 In-house 41-217 (297) alignment
Range on Protein: 650-827
Range on HMM: 41-217/297.0
YRKNPDlAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPGGAVnrYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMES
|. .|  . . |... |. |||.... ||| .||.| .   . . |||||  .  . |  ..  ||||||||||| .|||.|| .. . ..|.||.. |.
yeaeps.tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa..yiatqgplastvadfwqmvweqGvvvivnltrleee

GRQKCHQYWPVTGEELQlaEGFSVRCLSEKPdETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVR
| ..|..||| .|.|.   . . |. .||.   .  .. | | ||.  ..| | .  . .|.||.. ||. .. .|||  .| 
gvkqckrywpdeGsevy..hiyevhlvsehi.wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn

subfamily_PTPRD_pd Subfamily PTPRD 651-831 7.4e-54 178.3 In-house 33-211 (564) alignment
Range on Protein: 651-831
Range on HMM: 33-211/564.0
RKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG
....   ...|.|||| .|||| .| .|| .|| |    .    |||||....      . . |||||||||.|. |||||| .. |.  |||| . |.|
eegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr...krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkg

RQKCHQYWPVTGeELQLaEGFSVRCLSEKpdETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
..|||.||| .| . .  ... |   .|.  |   ...|.| ||  ...|.| ... .. .||||.||  .. .|.. ..|||...
kvkchkYWPekg.tety.geltVtleeee..eladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne

subfamily_eak_pd Subfamily eak 652-816 7.2e-12 39.3 In-house 38-198 (332) alignment
Range on Protein: 652-816
Range on HMM: 38-198/332.0
KNPDLAITEARKPANAPKNrYRDISPYDCTRVSLVNSLTG--DYINANYvnMEIPGgAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ
... |.|.|...  .  .|   .| |||   | | .|      ||||    .| .    ..|| |  .  .    ||.|| .. |  .|.|   .| . .
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasl..aefse.vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle

KCHQYWPVTG-EELQLAeGFSVRCLSEkpDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDP
|  .|.|  . |||.    . | . .    . . . .| ..|.   |  ...| ..  | .  .|   
ksdkyfpdktreelkfG.ildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpkye

0049772 (Phosphotyrosine protein) phosphatases II 653-955 3.5e-36 120.9 In-house 33-276 (314) alignment
Range on Protein: 653-955
Range on HMM: 33-276/314.0
NPDLAITEARKPANAPKNRYRDISPYDcTRVSLvN---SLTGDYINANYVNMEipggavNRYIATQGPLASTTTDF----------WRMV--QQESSHLL
 |.| |. |....|  |||| || |.| .|| | .     . |||||.||.        ...|||||||  |  ||          ||||  ..  .. .
lpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------LTTVMESGrqkcHQYWPVTGEELQlaegfsvrclsekpdetgsfvfrEFVLKDKHEQRHIHHMQYLAWPDHCVPsDP
||                     |..... |     .... . |.|.                       | .  ... .|.. .  .. .||...| ..
vmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk.......................eelydpelferlgikylripvpDgsap.ll

NLFLEFTERVRAArNrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaANPPVIVHCSAGIGRTGVLILMDTAL
. |.|| | ...| .                                                           .. ||.|||.||.||||......  .
edfdeflefieea.d...........................................................kggpvlvHCkaGkgRtgtfvvaaylm

ALMearePVYPLDIVRTMRDQRA-----CMVQNVSQYRFVCECI
 |.     | . .... .| .|       ....  || |. |..
kll....gvsleealedvrlkRpinpnpgfieqleqyefileal

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 653-832 1.1e-33 111.5 In-house 30-208 (315) alignment
Range on Protein: 653-832
Range on HMM: 30-208/315.0
NPDL-AITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNmeipGGAV-NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG
.||    . ||.. | .||||..| |.| .|| |    .|   ||||| |..    .    . |||.|||| ..  |||||| ||    .||.|   |. 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik....svdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegd

RQKCHQYWPV-TGEELQLaEGFSVRCLSEKPDetGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
. || ||||   ..  ..   ..|  || ..|  .  | |..|... .|.| .   |.  |||. |. .   .|..   |.| ...
kikcrqywPdrkadsvef.Gsikvellslead..tdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 653-828 7.2e-22 72.3 In-house 31-163 (392) alignment
Range on Protein: 653-828
Range on HMM: 31-163/392.0
NPDLA-ITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGr
.||.   | |.|. | .||||..| ||| .|| |    ..   ||.|| |..      . . |||.||| |..  |||||| ||    ..|.| . |   
gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf...dnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.

qkchqywpvtgeelqlaegfsvrclsekpdetgsfvfrefvlkDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
                                             ...| .   ..  |||. ||   . .|.| . |.|
...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 653-757 8.4e-14 45.8 In-house 84-180 (244) alignment
Range on Protein: 653-757
Range on HMM: 84-180/244.0
NPDlAITEARKPANAPKNRYRDISPYDCTRVSLVN-SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESgrqkc
.|   . .| .| |. |||     |.|  || | . |.   |||| .|      |    || || ||| |. |||.|. .    .||.| .| |      
dps.vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgcl...grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....

HQYWPV
 .||| 
deywpd

subfamily_PTPN23_pd Subfamily PTPN23 654-830 2e-41 136.7 In-house 33-204 (288) alignment
Range on Protein: 654-830
Range on HMM: 33-204/288.0
PDLAITEARKpaNAPKNRYRDISPYDCTRVSLVnSLTGDYINANYVNMEIPGGavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
 . .|. |..  .. |||.||| ||| .|| |  . . ||||| .|.   ||     .||||.||.||  |||.|| .. | ..|||..  | |..|...
rkrsiaiakl..yseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgc..PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPVTGEELQLAEGFSVRCLSEKpdETGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|||   .| .  . .|| . |..  ||. .| |.. |.  |... ... |.|. .||.. ||. |. .|.| . |..| 
YwPedkgetvkfgdlsvtlksvr..etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesay

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 654-811 3.3e-30 99.9 In-house 21-175 (283) alignment
Range on Protein: 654-811
Range on HMM: 21-175/283.0
PDLAITEARKPANAPKNRYRDISPYDCTRVSLvNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
|||  . |    | .|||...| |.|  || | .|.. ||||| .. ..      ..||..|.||  |  |||.|| .|    .|||| ..|  |.|| |
pdldadiasadenkrknrnqeivpadqwrvel.ksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPVTGEElQLAEgFSVRCLSEKpdETGSFVFREFVLKDK---HEQRHIHHMQYLAWpDHC
|||  | | .  | | |    |      ||. .|..|. .   ...  . | |.  |  ..
yWPkrGse.dyGe.ftvtlrket..tsnsfiikelllrvnssakstlllahyqvidW.ley

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 655-832 3.8e-29 96.8 In-house 37-213 (325) alignment
Range on Protein: 655-832
Range on HMM: 37-213/325.0
DLAITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHlLVMLTTVMESGRQKC
  | . | ||.|  |||.... ..| .|| |.    .   |||||.|.. ..     . ..|.| ||..|. |.||.| .  .  .|... ... | ..|
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk...kkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrc

HQYWPVT-GEELQLaEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
 .|||   |.  ..  |. |.  .   .|   .| | . .|. .  | | .. .|. .|.|  |.  |  .. ... | |  .|
avywpkemgksktf.Gglevklrti..eeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

subfamily_egg_pd Subfamily egg 656-804 4.9e-20 66.4 In-house 30-179 (307) alignment
Range on Protein: 656-804
Range on HMM: 30-179/307.0
LAITEARKPANAPKNRYRDISPYDCTRVSLV---NSLTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESgrQKCH
 ..|.| .  |  | | . .   | .|| |       ..|.| ||.|.    .  .| .| .| ||  |  |||||| ||  . .||||.  ||  ..|.
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPVTGEELQLA--EGFSVRCLSEKPDETGSFVF-REFVLKDKHEQRHIHHMQY
 ||| . ..       .. . .|  .      |   .  ..  ..|.|.. | |.
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 657-831 5.2e-42 139.1 In-house 47-219 (298) alignment
Range on Protein: 657-831
Range on HMM: 47-219/298.0
AITEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
  . ||||.|  |||| || ..| .|| | .      .||||| ...        | .||||.|| .|..|||||| .| .  .||||.. |... |.|.
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh...aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPVTGEELqlAEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
||| .|.|    . ..|. ||.  .| . .. |.. ...|.  ..|.......  |||..||.  .  |.. ..||| ..
ywPdegket..ygeitvsllsk..eefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq

subfamily_PTPN6_pd Subfamily PTPN6 658-832 2.2e-54 179.6 In-house 46-221 (306) alignment
Range on Protein: 658-832
Range on HMM: 46-221/306.0
ITEARKPANAPKNRYRDISPYDCTRVSL-VNSLTG-DYINANYVNMEIPGGAvNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
 .|..|| |. ||||. | |.| |||.|  .|..| |||||||.. |..|   ..|||||| | .| .|||||| ||.|...||.|. .| |..|| .||
rkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW

PVTGEELQlAEGFSVRCLSEkpDETGSFVFREFVL---KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
| . |. .     ||...||  ... ....||...   |.|.|.|....... .|||| ||.||. .|.| | |.. ...
Pdeeekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 658-829 1.9e-31 104.6 In-house 53-217 (319) alignment
Range on Protein: 658-829
Range on HMM: 53-217/319.0
ITEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTtvmesgRQKCHQY
 | |  . |  |||. .| ..| ..| | .       ||||| .|.        ..|||.||||  |  |||||. .  .  .|.||      ..|| ||
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy...qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPVTGEELQLAEGFSVRCLsekpDETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
||  ... .     .|  .    .||  .| |.. | .   ....|.|.   .| |||. ||  |  .. . ..||  
wplkivikeerfkvkvdsv....eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 658-827 6.2e-28 92.8 In-house 43-209 (297) alignment
Range on Protein: 658-827
Range on HMM: 43-209/297.0
ITEARKPANAPKNRYRDISPYDCTRVSLV--NSL-TGDYINANYVNmeipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRqKCHQY
 | |.|  | .|.||..| |||  || |   |.    ||.|| .|.     |  .|.|.|| |  .|  |||.|| .|    .|||.   |. . || .|
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk.....gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPVTGEELqlAEGFSVRCLSEkpDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPS--DPNLFLEFTERVR
|. .|         ||  ||   .|   |. ||....  .   .| ..  |.. |||. |.   . . .|.. . ||
Wsdkgvtt..fGdvsvvllsv..sereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 658-830 4.6e-25 82.8 In-house 29-200 (281) alignment
Range on Protein: 658-830
Range on HMM: 29-200/281.0
ITEARKPANAPKNRYRDISPYDCTRVSLV----NSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQ
 |   .| |  |||| .|   | .|| |     |  . ||| |||.   .       || ||||   | .|||||. || .  .|||  ..|. |.|| .
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf...lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPVTGEELQLAEGFSVRClsEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|.|         . .||    |      |.|   . |  . | | | |  .  |||  ||   ...|.   ..||  
yfprnahcclqfdklsvsy..edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars

0042113 (Phosphotyrosine protein) phosphatases II 659-956 1.7e-70 232.5 In-house 2-240 (245) alignment
Range on Protein: 659-956
Range on HMM: 2-240/245.0
TEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVnmeiP-GGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY
. |..|.| .||||.|| ||| ||| | .    |  |||||.||    .     ...|||||||..|. |||||.... .. .||||. .| ||.||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRaarnrtllqeieeslkqvrlmdada
||   .| .  ..|.|..|||.    .... |.. ..   ..|.|...|..|| ||||.||....|.|.| |.||                         
wpl..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr.........................

dadengglmrerkcaasngatpedetpvstsvhQCIS-AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFV
                                 ....  .| ||.||||||.||||..|.....| ..|..  | . ..|. .|.|| ..||. |||||.
.................................kalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

CECIC
 |...
yeall

0040439 (Phosphotyrosine protein) phosphatases II 659-957 5.4e-70 231.1 In-house 4-244 (249) alignment
Range on Protein: 659-957
Range on HMM: 4-244/249.0
TEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPGGAvnrYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
..|..|.| .||||.|| ||| .|| |        .|||||.|...   . .   .||||||| .|. |||||.... .. .||||. .| ||.||.|||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr...fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PVtgEELQLAEGFSVRCLSEKPdeTGSFVFREFVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRaarnrtllqeieeslkqvrlmdadad
|   .. .  ..|.|..||..    .... |.. |.   . | |...|.||. |||| ||.... .|.| |.||                          
pl..ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr..........................

adengglmrerkcaasngatpedetpvstsvhQCIS--AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFV
                                ....    . ||.||||||.||||..|.....| ..| .  | ....|...|.|| ..||| .||||.
................................kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

CECICA
.|... 
yealle

subfamily_CG42327_pd Subfamily CG42327 659-955 2.2e-38 126.7 In-house 21-311 (319) alignment
Range on Protein: 659-955
Range on HMM: 21-311/319.0
TEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
...  ..  .|.|. .. |   ||| | .        |..|.||    .  | | |||.| .| ....||||.| .  |  .| || . | | ..| .|.
adevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrG..yddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeyl

PV--TGEELQLAEGFSVRClseKPDET-GSFVFREFVLK--DKHEQRHIHHMQYlAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDA
|   |... .|   . |     |  |.   ..   ..||  ||.| |.. |  |  |..  ||.... ..    .||.. .   |.. .|  ..   ...
PtketldntslyGdilvtl...kgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslksysleqanelreksatlet

DADADENgglmrerkcAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAR-EPVYPLDIVRTMRDQRACMVQNVSQYR
  ||| .          |  |.|   |     | .      . |..|||| |.||||..|  | |.  .|   . |   ..|  .| .||  |... || 
smdadgs.........kaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqye

FVCECI
|.   .
fiykvl

subfamily_PTPRK_pd Subfamily PTPRK 659-830 1.2e-36 121.2 In-house 36-206 (314) alignment
Range on Protein: 659-830
Range on HMM: 36-206/314.0
TEARKPANAPKNRYRDISPYDCTRVSLVNsLTG----DYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY
  |.|  |  |||. || .|| .|| |.  . |    |||||....        . .|.||||| .|..||||.| .| .  .|||| ..| || || .|
daakkdenreknrsgdilaydrsrvflit.idgdpssdyinaalidsy...krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

WPVTGEElqlAEGFSVRCLSEKPDEtgSFVFREFVLKD----KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
||  .|     . . | ... ....   .| | | ..     ..|.| ....|.|.|||| ||   . .|..  || . .
WPedtev...ygdikvelvetella..elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 659-823 8.3e-34 111.7 In-house 31-194 (287) alignment
Range on Protein: 659-823
Range on HMM: 31-194/287.0
TEARKPANAPKNRYRDISPYDCTRVSLVN--SLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWP
 .| . |.. |||| |. |.| ||| |..   |  ||||||||         ...||.|||.|.|  ||||.| .. |  ....|  .| .|.||..|||
kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasy...tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

VTGEELQLAeGFSVRCLSEKPDETGsFVFREFVLKDK--HEQRHIHHMQYLAWPDHCVPSDPNLFLEFT
     ...  |.||  |. .  |   .  | . | |   .| | .. ...|.|||. ..     .. |.
erevPmrvG.GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfv

subfamily_PTPRA_pd Subfamily PTPRA 659-831 1.6e-33 111.0 In-house 51-225 (330) alignment
Range on Protein: 659-831
Range on HMM: 51-225/330.0
TEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
  | |  |  |||. .| ||| .|| | .     . ||||| ...        ...||.|||.. |  |||||. .  |. .|||| . |  ..||.|||
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy...kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PVTGeelQLAEGfSVRCLSEKPDETGSFVFREFVLK------DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
|  |    .. |  .|   |.  .. ..  |.|...      .....| .. . . .|||  ||..|   |.. ..|.. ..
PdeG...lvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 659-829 6.8e-31 102.8 In-house 18-181 (284) alignment
Range on Protein: 659-829
Range on HMM: 18-181/284.0
TEARKPANAPKNRYRDISPYDCTRVSLVNS---LTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTtvmesgRQKCHQYW
| |  . |  |||. .| ..| ..| | .       ||||| ...        ..||||||||  |  |||||. .  .  .|.||      ..|| |||
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy...qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PVTGEELQLAEGFSVRCLsekpDETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
|  ... .     .|  .    .|.  .| |.. | .   ....|.|. . .| |||. ||  |  .. . ..||  
plkivikeerfkvkvdsv....eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 659-832 1.6e-30 100.7 In-house 36-207 (515) alignment
Range on Protein: 659-832
Range on HMM: 36-207/515.0
TEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNmeipGGA-VNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY
| |..  | .||||..| ||| .|| |    ..   ||.|| |..    .    . |||.|||. ... ||||.| ||    ..|.|   |. . || .|
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip....sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky

WPV-TGEELQLAEgFSVRCLSEKPDeTGSfVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
||   |. ... . ..|  .| . . ||  . |.. .    . | .   ..  |||. || . . .| .   |.| ...
WPdkpgdsvkfGs.ikvelvsleac.tgg.ikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgq

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 659-829 1.8e-28 94.4 In-house 42-207 (315) alignment
Range on Protein: 659-829
Range on HMM: 42-207/315.0
TEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
  |.|  |  |||| .| .|| .|| |    |    ||.|||...        .||||.|||....  ||||.| .|    .|||| ..|  ..|. .||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy...nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PVTgeELQLAeGFSVRCLSEKPDEtgSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA
|    ..     ..|   ||.  .   .  | .    . . |..  ..| .|||  ||     ....  .|.  
pdk..kviyG.kitvtrkseevnt..eytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh

subfamily_ptpA1_pd Subfamily ptpA1 659-830 9.6e-26 85.4 In-house 40-219 (418) alignment
Range on Protein: 659-830
Range on HMM: 40-219/418.0
TEARKPANAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNMEIPggavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW
.|  |  |. |||| .| | . ||| | .       |||||||..   |    ...|.|||||  | .|||||| ..  ...|||.   |  | || .||
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp....kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

P--VTGEELQL-------AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
|  . ||.. .          .||  .    |     . |.  |  . | | | . ||  |||| .|   . | ..   .   .
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 659-816 1.5e-12 41.7 In-house 40-190 (303) alignment
Range on Protein: 659-816
Range on HMM: 40-190/303.0
TEARKPANAPKNRYRDISPYDCTRVSLVNSltgDYINANYVNMEipggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVT
.  .   |  |||. |.   | ..| | .|    || |.|....    . .. | || ||. |..|||.|. ..  . ...| |  |  .   .  .|  
sknqfvknmdknrfvdvicldhskvklsds...syihasyleld....sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

GEELQLAEGfSVRCLSEKPDET-GSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDP
 . |.. |  |.|    |  |    .|..   . . . .  .|  .| |||   .||| 
qdflkfeer.sirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdg

0037934 (Phosphotyrosine protein) phosphatases II 660-956 2.3e-69 228.9 In-house 4-239 (243) alignment
Range on Protein: 660-956
Range on HMM: 4-239/243.0
EARKPANAPKNRYRDISPYDCTRVSLvNSltGDYINANYVNMEiPggavnRYIATQGPLASTTTD----FWRMVQQESSHLLVMLTTVMESGRQKCHQYW
 |..|.| .||||.|| |||..|| | ..  .||||||....  |     |.||||||| .|. |    ||||.... .. .||||. .| ||.||.|||
iallpenlsknrysdilpydhsrvkl.eg..sdyinanliyvt.p.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PvtGEElqLAEGFSVRCLSEKPdeTGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEieeslkqvrlmdada
|  ||.    ..|.|..|||.   ..... |...|.    ....|...| .||.||||.||..|. .|.| . ||.  ...|.                 
p..gev..tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll...............

dadengglmrerkcaasngatpedetpvstsvhqcISAANPPVIVHCSAGIGRTGVLILMDTALALMearePVYPLDIVRTMRDQRAC-MVQNVSQYRFV
                                       . ||.||||||.||||.||.... | |.     | ....|...|.|| . .||. |||||.
...................................aldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfl

CECIC
 |...
yeall

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 661-832 1.3e-39 130.9 In-house 4-172 (250) alignment
Range on Protein: 661-832
Range on HMM: 4-172/250.0
ARKPANAPKNRYRDISPYDCTRVSLVNSL---TGDYINANYVNMEIpgGAvNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQkCHQYWPV
|.||.|  |||| || ..| .|| | ..      ||||| ...     .  . .||||||| .|. |||||| .| |  .||||.. ||... .||||||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd..er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

TGEElqLAEGFSVRCLSEkpDETGSFVFREFVLKDKHEQR--HIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR
 . |     .  |  ||.  .| . .. |...|  ....   .. ......||| .||   .  ||. ..|.| ...
ekae..kyGdvtvsllsk..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 661-815 3.7e-27 90.0 In-house 3-155 (239) alignment
Range on Protein: 661-815
Range on HMM: 3-155/239.0
ARKPANAPKNRYRDISPYDCTRVS---LVNSLTGDYINANYVNMEipGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV
|.|  |  |||| .|  || .||    | |    |||||.|.      |. . |||||| .. .. |||||. ||   ..|||| ..|  ..||||||| 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TGEELqlaegFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSD
.  .        .|    | .    .. | ||. .  . |.|.... ..  |||. ||  
stsky.....cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 661-815 4.6e-27 89.7 In-house 2-154 (239) alignment
Range on Protein: 661-815
Range on HMM: 2-154/239.0
ARKPANAPKNRYRDISPYDCTRVS---LVNSLTGDYINANYVNMEipGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV
|.|  |  |||| .|  || .||    | |    |||||.|.      |. . |||||| .. .. |||||. ||   ..|||| ..|  ..||||||| 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TGEELqlaegFSVRCLSEKPDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPDHCVPSD
.  .        .|    | .    .. | ||. .  . |.|.... ..  |||. ||  
stsky.....cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 661-831 8e-24 78.9 In-house 43-208 (439) alignment
Range on Protein: 661-831
Range on HMM: 43-208/439.0
ARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRqkchqYWPV
| .  . .||||.|....| ||| |          ||||||..        . |||||||   || ||||.| .. .  .|||| ..|| .     ||| 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy...ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

TGEELQlaEGFSVRClsEKPDETGSFVFREFV---LKDKH-EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN
 .|        .||.  ..  |   .| | |     .|.   .| . ...|.||||. ||..    |.|   . .| .
daevcy..gdiavrv..drnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 661-716 1.4e-09 32.0 In-house 43-95 (95) alignment
Range on Protein: 661-716
Range on HMM: 43-95/95.0
ARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEipgGAVNRYIATQG
    || ||||. .| |||.||| |      ||||| .|.        | |||.||
gsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy...arkncyiaaqg

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 662-959 5.2e-58 191.3 In-house 24-268 (274) alignment
Range on Protein: 662-959
Range on HMM: 24-268/274.0
RKPANAPKNRYRDISPYDCTRVSL----VNSLTGDYINANYVNMeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV
. . .. ||||..| | . .||.|    ...   .||||||.    ...  . |.||||||..| .|||||. ||.....|||| . |. .|||..|.| 
dvfgsqtknryktilPnensrvllesessededssyinanyikG..ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

TGeELQLAEGF-SVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVraarnrtllqeieeslkqvrlM--------
.  .....| .  |    ||  |.  .  |..|||  ...|...|. | .|||| .| |.| .|.. . |                              
ae.dyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev.....................eesreeena

----DadadadengglmrerkcaasngatpedetpvstsvhqcisaanppvIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQN
                                                   .|||||||||||. | .. |.  ..... |  | ||  .| .|  |||.
klapv..............................................vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt

VSQYRFVCECICAAY
 .||... . .|   
seqyelihralclyl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 662-827 2.1e-21 71.1 In-house 31-197 (285) alignment
Range on Protein: 662-827
Range on HMM: 31-197/285.0
RKPANAPKNRYRDISPYDCTRVSLVNSlTGDYINANYvnMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEE
   ||   ||| |.   . ||| | |    ||| |..  | .||   . ||.|||||  | .|||.|. ||    ..|| |..| | .||  |.|    |
ayeanpdlnryadvrcieetrvvlknh.drdyihasw..mrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

LQLAEGFSVRCLSEKPDETGSFVFREFVLKD----KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVR
.     . .     | .     ..  . . .      |  .. |.|   |||.  | |   ..|. . |.
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 665-824 5.6e-22 72.8 In-house 49-208 (301) alignment
Range on Protein: 665-824
Range on HMM: 49-208/301.0
ANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL
 .  |.||  .     | | ...  .   | ||... .   |  .|.||||||| .|. ||| |..|   . .|||.  .|   .||..| ||. .|   
lpkdkhryptvPckPstavevivdGkrvPihanwipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

AEGFSVRCLSEKPDETGSFVFREFVLKD---KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE
 . |...  ...     . . |.. ..|   | . | . | ||  |.|. ||       .. |
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 665-830 4e-19 63.7 In-house 42-204 (288) alignment
Range on Protein: 665-830
Range on HMM: 42-204/288.0
ANAPKNRYRDISPYDCTRVSLVNSlTGDYINANYVNmeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV-TGEELQ
||. ..||...   | ||| | .  .  ||.|| |     .   .| | .| || .|   .|.|. ..  . .|||. ..| |..|  .|.|.  ||. .
anptrdryenlprcditrvklsdd.pdfyiaanvvs...sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

LAEGfsVRCLSEKPDETGSFVFREFVLKDKHEQRH--IHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
.          .| ..    |    .   |. . .  . .. .| |.|..|| .   .| . |.... .
igrl..ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 665-798 2e-14 48.3 In-house 32-156 (267) alignment
Range on Protein: 665-798
Range on HMM: 32-156/267.0
ANAPKNRYRDISPYDCTRVSLVNSlTGDYINANYVNMEIPGgavNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVmesGRQKCHQYWPVTGEELQL
 |. .||. |  ||| ||| | .. . .|||| ||.    .   | .|.||.||  | |||. .....     |.||.|   . .. ...||    . . 
knqernrlddnlpyddtrvilrtk.eeeyinasyvegyktk...nafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

AEGFSVRCLSEKPDETGSFVFREfvLKDKHEQRH
 . ..|    || ..    .  |  || | |  |
yqdltvehslekeendyqiitle..lkfknesah

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 665-764 6.3e-06 19.8 In-house 50-147 (302) alignment
Range on Protein: 665-764
Range on HMM: 50-147/302.0
ANAPKNRYRDISPYDCTRVSLVNsLTGDYINANYVnmEIPGGAvNRYIATQGPLASTT---TDFWRMVQQESSHLLVMLTTVMESGRqKCHQYWPVTGEE
.|  ||.  |.  .| ..| | .    .|.||  |  |.|    .  | .| |  ...    .||||| ||.   .|.|    |  .   ....| . ..
knlkknqsedvpildsnlvklea.epdsyvnaskv..evPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

LQL
 . 
yke

Y_phosphatase Protein-tyrosine phosphatase 666-955 2.3e-71 235.3 Pfam-A 1-233 (235) alignment
Range on Protein: 666-955
Range on HMM: 1-233/235.0
NAPKNRYRDISPYDCTRVSLVNSL-TGDYINANYVNMEIPggaVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL
|  ||||.|| ||| ||| | .|  . ||||||||..       ...||||||| ||  |||||| || ....||||...|.||.||.|||| . || . 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQ---RHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglm
 . ..|.. ... ... ....|.. ||.| |.   |......| .||||.||..|. .|.. ..|.  .                               
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...............................

rerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
                           .| . ||.||||||.||||.....|..|  .||.| |  |.||...| ||. |||...|| |....|
...........................eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 666-955 2.3e-71 235.3 In-house 1-233 (235) alignment
Range on Protein: 666-955
Range on HMM: 1-233/235.0
NAPKNRYRDISPYDCTRVSLVNSL-TGDYINANYVNMEIPggaVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL
|  ||||.|| ||| ||| | .|  . ||||||||..       ...||||||| ||  |||||| || ....||||...|.||.||.|||| . || . 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQ---RHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglm
 . ..|.. ... ... ....|.. ||.| |.   |......| .||||.||..|. .|.. ..|.  .                               
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...............................

rerkcaasngatpedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
                           .| . ||.||||||.||||.....|..|  .||.| |  |.||...| ||. |||...|| |....|
...........................eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

0041856 (Phosphotyrosine protein) phosphatases II 666-959 1.9e-45 150.0 In-house 1-171 (182) alignment
Range on Protein: 666-959
Range on HMM: 1-171/182.0
NAPKNRYRDISPYDCTRvslvnslTGDYINANYVNMEIPGGAvnrYIATQGPLASTTTDFWRMVQQESSHLLVMLTtvmesgrqkCHQYWPvtgeelqla
| .||||.|| ||| .|         ||||||.. .  |.     .||||||| ||. ||.||....  ...|.||         ...|||         
nldknrysdilpydhsr.......dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

egfsvrclsekpdetgsfvfrefvlkdKHEQRHIHHMQYLAWPDHCVPSdPNLFLEFTERVRAarNrtllqeieeslkqvrlmdadadadengglmrerk
                           ....|.... .|| ||||.||. .. .|.| |.|..  .                                  
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..e..................................

caasngatpedetpvstsvhqcisaaNPPVIVHCSAGIGRTGVLILMDtalaLMEAREpVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
                          . ||.||||||.||||.|....    ||. .. | . ..|...| .| .||.. .||.|.  ...  .
..........................ggpvlVHCsaGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 666-817 5e-37 122.3 In-house 20-172 (270) alignment
Range on Protein: 666-817
Range on HMM: 20-172/270.0
NAPKNRYRDISPYDCTRVSLVN---SLTGDYINANYVNmeIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEEL
..  |||.|| |   ||| | .     .  |||||||.     |. ..|||..|||..|...||||. .| .. .||.| ..| ||.|| .|||   .| 
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr..GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

QLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPN
   |   .. |...   .  .....  |..| |.|.. | .| .|||| ||....
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreed

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 666-826 4.9e-32 106.0 In-house 3-162 (237) alignment
Range on Protein: 666-826
Range on HMM: 3-162/237.0
NAPKNRYRDISPYDCTRVSLVNSL-TGDYINANYVNMeIpGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELql
|  |||| .|  || .|| |  .  . |||||.|..  .  |. ..|||.|||| |.  |||.|| ||   ..|||| ..|. ..|||.||| | .    
nkiknrygnivaydhsrvvlkgagsgsdyinatylkg.f.dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa..

AEGFSVRCLSeKPDETGSFVFREFVLKDKH---EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
| |     |  | .|   .  | ..|  ..   | | ||  |. .|||. ||     .| |  ..
aygvltvslk.kkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 666-830 6.4e-26 85.7 In-house 55-221 (305) alignment
Range on Protein: 666-830
Range on HMM: 55-221/305.0
NAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMeiPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV-TGEELQL
.  ||||.|.   | . | | .    ||| ||||    |    .|.|..||||  |  .|| || |.    .|||   .| |. || ||||.  || |.|
aitknryqdvpcqdqsavkldkpspsdyihanyvgc..pmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

AEGFSVRCLS-EKPDETGSFVFR-EFVLKD-KHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR
  |  |  .|  || |  . .    . |     ..  . |.|.  |||  ||      ||.   .| ..
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 666-731 3.8e-06 20.6 In-house 37-107 (347) alignment
Range on Protein: 666-731
Range on HMM: 37-107/347.0
NAPKNRYRDISPYDCTRVSLVNS-----LT---GDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQ
.  ||| .|    | ||| |         .     |||| .....    | . || || || .|  |||.||. 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfd...naskeyiltqyplpdtvrdfwkmvsv

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 667-826 4.2e-33 109.2 In-house 57-212 (290) alignment
Range on Protein: 667-826
Range on HMM: 57-212/290.0
APKNRYRDISPYDCTRVSLVNSLTGDYINANYVNmeipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAE
  ||||.|.   | ||| | .   |||. ||||.     |    .| |||.|..|. |.|||| ||    .|||  ..| |. ||.||.| .  |     
fkknrykdvvcndktrvilkdGydGdyvhanyvk.....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

GFSVRCLSEKpDETGSFVFREFVLKDKHE--QRHIHHMQYLAWPDHCVPSDPNLFLEFTERV
 ..| |  |. |.    . . . ..||..  .  ..|..  .|||..|.     .|     .
eitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 667-758 2.5e-25 83.9 In-house 48-153 (350) alignment
Range on Protein: 667-758
Range on HMM: 48-153/350.0
APKNRYRDISPYDCTRVSLVN-----------SLTGDYINANYVNMEIPGGAVN---RYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCH
  ||||..| ||. .|| | .             | |||||||.... ..  .|   .|||||.|| ||  ||.... .   .....||. .| ...||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPVT
.||.  
rYWqeg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 667-755 7.5e-14 45.8 In-house 49-153 (349) alignment
Range on Protein: 667-755
Range on HMM: 49-153/349.0
APKNRYRDISPYDCTRVSLVNSL-----------------TGDYINANYVNMEIPgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ
  ||||.|| ||. .|| | .||                   |||||||...     . ..||||| || ||  ||....  .  .|.. |.   | . .
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltri.svekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHQYW
||..||
kcdiyw

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 670-815 1.2e-13 45.4 In-house 47-194 (312) alignment
Range on Protein: 670-815
Range on HMM: 47-194/312.0
NRYRDISPYDCTRVSLVNSlTGDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL--AEG
||| .|  .|  | .|       || ||.|..       .|...||||| .|.| ||...   .|  ...|....| | .|| .|       ..|     
nrypniqcwdrgrftlagd.enfyihanfvkict...kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

FSVRCL----SEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSD
..  |       |  .  .      |.|   .. .. | |. .|||| .|  
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds

0044763 (Phosphotyrosine protein) phosphatases II 677-954 3.3e-31 103.7 In-house 1-166 (178) alignment
Range on Protein: 677-954
Range on HMM: 1-166/178.0
PYDCTRVSLVNSLT---GDYINANYVNmeiPGgavnRYIATQGPlasttTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEelqlaegfsvrcl
|.| |||.| |      .|||||...    ||     |.....|      |........  ...|.||. .| |..||..|||   .             
pldrtrvllsnleglersdyinaseil...pg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............

sekpdetgsfvfrefvlkdkheqrhiHHMQYLAWPDHCVPSDPNLFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglmrerkcaasngat
                           ..... .|||.||. .  ||||.| ...|.                                           
..........................iqylhipipDhgvpdllehflefvefieeal...........................................

pedetpvstsvhqciSAANPPVIVHCSAGIGRTGVLIlmdtALALMEARePVYPLDIVRTMRDQRAcMVQNVSQYRFVCEC
               .  . ||.||||||.||.|.|.    |. ||  .  . . .... .| .|  .|.| .|.|...|.
...............dekggpvlVHCsaGvgRsgtlv....aaylmkkl.glsleeaielvrerRp.ivpnpgqlrqLyef

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 677-757 2.1e-08 28.5 In-house 4-71 (130) alignment
Range on Protein: 677-757
Range on HMM: 4-71/130.0
PYDCTRVSlvnslTGDYINANYVNMEipgGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESgrqkcHQYWPV
... .|.        .||||..| .    |  . |. || ||| |..|||.|. .    .||.| .| |       .||| 
efevsrlq.....gntyinasfvGll...grtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 687-828 4e-17 57.3 In-house 42-189 (290) alignment
Range on Protein: 687-828
Range on HMM: 42-189/290.0
NSLTGDYINANYVNMeiPGGavNRYIATQGPLA-------STTTDFWRMVQQESSHLLVMLTTVMESGRQ----KCHQYWPVT-GEELQLaEGFSVRCLS
. .. ||| ||.| .  | |   | |.|| |..       ||  .|| |..|| .. .|||  ..|  ..     | .| | . ||||.. .|..|.| |
krfnddyiHAnrvtc..png..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf.kgltvkCks

EKPDEtgSFVFREFVLK-DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA
   ..   .  || |.| |..|.  . | ..  | .  |. |. ..|.  . |.|
keked..dvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvka

0046846 (Phosphotyrosine protein) phosphatases II 690-832 3.8e-21 71.1 In-house 11-108 (176) alignment
Range on Protein: 690-832
Range on HMM: 11-108/176.0
TGDYINANYVNMEipggavnRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVtG-EELQlaegfsvrclsekpdetgsfvfref
  ||||||.. .        |.||||||| .|. ||..|....  ...|.||. .| || ||..|||.   ..                           
dldyinanlilgs.......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi.........................

vlkdkheqrhihHMQYLAWPDHCVPSDpNLFLEFTERVRAARNR
            . ..| ||||.||.. .|.||. | .| |...
............qylhlpwpDhgvpdl.elllellefirealke

0036282 (Phosphotyrosine protein) phosphatases II 691-952 4.2e-43 142.4 In-house 2-163 (174) alignment
Range on Protein: 691-952
Range on HMM: 2-163/174.0
GDYINANYVNMEIPGGavnRYIATQGPLAstttdFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVtgeelqlaegfsvrclsekpdetgsfvfrefvl
 |||||..... .  .   |.||.|||||     ||.|....... .|||.. .| |. ||..|||                                  
sdyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

KDKHEQRHIHHMQYLAWPDHCVPSDPNlFLEFTERVRAARnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisA
. ... |.... .|| ||||.||...  .||| ..|. |.                                                           .
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal...........................................................s

--ANPPVIVHCSAGIGRTGVLILMDTALALMEaREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
   . ||.||||||.||||.|....  | ...   .|  ||.||..| || .|||. |||||. 
edpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

0043147 (Phosphotyrosine protein) phosphatases II 691-952 2.2e-39 130.3 In-house 5-154 (172) alignment
Range on Protein: 691-952
Range on HMM: 5-154/172.0
GDYINANYVNMEIpggAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVmesgrqkchqywpvtgeelqlaegfsvrclsekpdetgsfvfrefVL
 |||||.|... .     .|.||||||| .|. |||||....  ...|.||.                                              ..
sdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

KDKHEQRHIHHMQYLAWPDHCVPsDPNLFLEFTERVRA--ARNRtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqci
  ....|.. . .|| ||||.|| ...|.||| | ..   |...                                                        
dpellerlgiqylylpwpDhgvp.llellleflefidellalsp........................................................

saaNPPVIVHCSAGIGRTGVLILMDTALalmearEPVYPLDIVRTMRDQRACMVQNVSQYRFVC
   . ||.||||||.||||.|....  |      . . ....|...|..| ..||| |||||..
...ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

0051429 (Phosphotyrosine protein) phosphatases II 691-833 4.4e-24 81.0 In-house 4-152 (272) alignment
Range on Protein: 691-833
Range on HMM: 4-152/272.0
GDYINANYVNMEipgG---AVNRYIATQGPLASTTTDFWRMvQQESSHLLVMLTTVMESGRQKCHQYWP--------VTGEELQLAEGFSVRCLSEKPDE
..||||..|..    |     .|.....|||  |  ||||. ...  .  |.|....| ||.||..|||        . ... .  . . .|    .   
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TGSFVFREFVLK---DKHEQRHIHHMQYLAWPDHCVPSDPnlFLEFTERVRAarNRT
.  .. ||..|.   . .| |...|..|..||||.||...  .||. | ...  .. 
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..ggp

0051082 (Phosphotyrosine protein) phosphatases II 692-953 7.5e-29 95.7 In-house 4-147 (151) alignment
Range on Protein: 692-953
Range on HMM: 4-147/151.0
DYINANYVNmeipGGavnrYIATQGPLAstttDFWRMVQQESSHLLVMLTTVMESGrqKCHQYWPVTGeelqlaegfsvrclsekpdetgsfvfrefvlk
||||..||     ||    .....||||    ||.......     |.|.. .| |  .|..|.| .|                                
dyinfsyvt....gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

dkheqRHIHHMQYLAWPDHCvpsdpnlfleftervraarnrtllqeieeslkqvrlmdadadadengglmrerkcaasngaTPEDETPVSTSVHQCISAA
     ....|...| |||.                                                              .|.    |   ......  
.....ievlhipildwpdpg.............................................................lplsfdavleflellldkk

NPPVIVHCSAGIGRTGVLILMDTALaLMearepVYPLDIVRTMRDQRACMVQNVSQYRFVCE
| ||.||||||.||||.|....  | |.     | . .... .| .|  .||   |..|.  
ngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfqlf

0049260 (Phosphotyrosine protein) phosphatases II 709-828 3.1e-17 58.1 In-house 9-83 (152) alignment
Range on Protein: 709-828
Range on HMM: 9-83/152.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWpvtgeelqlaegfsvrclsekpdetgsfvfrefvlkdkheqrhihHMQYLAWP
...||||||.  |. |||||...   . .||||. .| |. ||.||.                                             . ..| ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHCVPSDPNLFLEFTERVRA
||.||... |.|.. . .. 
Dhgvpdlsqlllflllfiek

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 709-823 2.2e-10 35.1 In-house 4-119 (198) alignment
Range on Protein: 709-823
Range on HMM: 4-119/198.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSV--RCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLA
 |||||| ||  | .|||.|| .  |  .||.             |||.|         .||  .... ||| | . .            | | | |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHCVPSdPNLFLEFT
| ..  |    ||. | 
wkekttpn.valfvgfv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 709-823 2.4e-10 34.9 In-house 5-120 (199) alignment
Range on Protein: 709-823
Range on HMM: 5-120/199.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSV--RCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLA
 |||||| ||  | .|||.|| .  |  .||.             |||.|         .||  .... ||| | . .            | | | |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHCVPSdPNLFLEFT
| ..  |    ||. | 
wkekttpn.valfvgfv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 709-810 5.9e-09 29.7 In-house 236-331 (440) alignment
Range on Protein: 709-810
Range on HMM: 236-331/440.0
NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMEsgrQKCHQYWPVTGEELQLAeGFSVrclSEKPDE-TGSFVFREFVLKDKHEQRHIHHMQYLAW
| .|||| || ||  ||||.|..     ..||  . .   . |  ||||    . .   |.|     |  |       | . || | |   |  ..  .|
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfg.pftv...ghkgsenmnrvkvrtlelkykeevheirqfevqtw

PDH
|  
ptw

subfamily_hpo-7_pd Subfamily hpo-7 713-829 2.5e-10 34.7 In-house 42-154 (263) alignment
Range on Protein: 713-829
Range on HMM: 42-154/263.0
AtqgpLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDET-GSFVFREFVLKdKHEQRHIHHMQYLAWPDHC
     |  |   |.....|  .. .|||.   | |..|| .|.|.  .| |  .  .| .   . |    . .. . . . | . . ..| .|  |... 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekn

VPSDPNLFLEFTERVRAA
 | ...  |.  . .|  
dpelareilnilkvarns

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 716-822 6.3e-07 23.1 In-house 98-213 (302) alignment
Range on Protein: 716-822
Range on HMM: 98-213/302.0
GPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV-TGEELQLAEgFSVRCLSEKP------DETGSFVFrEFVLKD----KHEQRHIHHMQY
 |  ||.  .| ...| .  . | |....|.. .|| .|.    |.||.. . ..|. .| |       |  .  ..    .|.    |. .. .. ...
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgr.ytvktvsvktdleeftdkksfkly.tveiknekkkkkvkktvdilaf

LAWPDHCVPSDPNLFLEF
 |||||  | ...  |. 
sawpdhGapkeaytaldi

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 721-829 3.4e-11 37.7 In-house 40-148 (255) alignment
Range on Protein: 721-829
Range on HMM: 40-148/255.0
TTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFL
|   |.....|  .. .|||.   | |..||..|.|.  .| .  .  .| .     |     .     | .| . . ..| .|  |...  | ...  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

EFTERVRAA
.    || .
nilkvvrds

0048076 (Phosphotyrosine protein) phosphatases II 794-955 3.9e-23 77.1 In-house 42-139 (145) alignment
Range on Protein: 794-955
Range on HMM: 42-139/145.0
HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNP
 . |.. . .|| ||||.||....|.||| | ...|...                                                           . 
llerlgiqylylpwpDhgvpdllellleflefieealke...........................................................gg

PVIVHCSAGIGRTGVLILMDtalaLMEAREpVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
||.||||||.||||.|....    ||  .  | . .... .| || ..|.|..|.||..|..
pvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 795-953 1.3e-21 72.2 In-house 45-139 (144) alignment
Range on Protein: 795-953
Range on HMM: 45-139/144.0
EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAArnrtllqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqciSAANPP
. |.... ..| ||||.||....|.||| | ...|                                                            . . |
leregiqylhlpwpDhgvpdllellleflefieea...........................................................leeggp

VIVHCSAGIGRTGVLILMDtalaLMEAREpVYPLDIVRTMRDQRACMVQNVSQYRFVCE
|.||||||.||||.|....    ||  .  . . .... .| .| ..|.| .|.||..|
vlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle

PTPc_DSPc_SM00012 799-955 8.4e-28 92.0 In-house 2-103 (105) alignment
Range on Protein: 799-955
Range on HMM: 2-103/105.0
IHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLqeieeslkqvrlmdadadadengglmrerkcaasngatpedetpvstsvhqcisaaNPPVIVH
..|..|..||||.||.... .||. . |.  .|                                                            ..||.||
vkhyhytgwpdhgvPeesdsilellravkknknkses........................................................skpvvVh

CSAGIGRTGVLILMDTALALMEAR-EPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
||||.||||.....|..|  .|.. . |  ..||. .|.||. |||.  || |.....
CsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral

subfamily_PTPRG_pd Subfamily PTPRG 871-957 7.8e-15 49.1 In-house 196-285 (563) alignment
Range on Protein: 871-957
Range on HMM: 196-285/563.0
GATPEDETPVSTSVHQCISAANP---PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 ..|| ..|| . |..   | .    |..||||||.||||..| .|| |  ..... |  .......| ||  .||.  || |. . .  
hgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle

PTEN_1 873-938 2e-06 22.7 In-house 109-171 (196) alignment
Range on Protein: 873-938
Range on HMM: 109-171/196.0
TPEDETPVSTSVHQCISAANP--PVIVHCSAGIGRTGVLILMdtalALMEAREpVYPLDIVRTMRDQR
. .    .  |..........   |.||| ||.||.|... .     ||...    . . .. .|..|
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgk.ltadeAlelvrekR

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 874-952 1.5e-09 32.2 In-house 183-263 (285) alignment
Range on Protein: 874-952
Range on HMM: 183-263/285.0
PEDETPVSTsVHQCI---SAANPPVIVHCSAGIGRTGVLILMDTALA-LMEaREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
|||  |.   ... .      . |. ||||||.|||  .. .| |   .||    .  ||||| ||  |   ||.  |. |. 
pedarpmie.lykwvkkvnpkekpicvhcsagvgrtatfvgidyatirime.npniemldivremramrfqavqshmqflfly

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 879-962 8.7e-09 29.9 In-house 178-262 (290) alignment
Range on Protein: 879-962
Range on HMM: 178-262/290.0
PVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALME-AREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKI
 . .|. | . | . ||||||  || |  .|  .. .  ..   .. |   |.. ..| ||| ....  .. ||   |    ...
ktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaiev

0051429 (Phosphotyrosine protein) phosphatases II 881-962 1.7e-19 66.0 In-house 140-228 (272) alignment
Range on Protein: 881-962
Range on HMM: 140-228/272.0
STSVHQCISAaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVY--------PLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKI
  .. . . . . ||.||||||..|||......  |. ...   |         ....|. .|.||...||.  ||.|..|.. ......
llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 882-961 5.2e-15 50.4 In-house 208-290 (325) alignment
Range on Protein: 882-961
Range on HMM: 208-290/325.0
TSVHQCISA---ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
  |.... |   |  |..||||||.|||||.| . .||| .     |  .. |. .| .|  ||. | || .. |..  ||| 
kavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

0046846 (Phosphotyrosine protein) phosphatases II 883-956 2.4e-18 62.0 In-house 101-170 (176) alignment
Range on Protein: 883-956
Range on HMM: 101-170/176.0
SVHQCISAaNPPVIVHCSAGIGRTGVLILMDtalaLMEAREPVYPLDIVRTMRDQRA-CMVQNVSQYRFVCECIC
 ....... . ||.|||||||||||.|....    |.| .  . ........|.||  ..||. .||||. |...
firealke.ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel

subfamily_PTPRD_pd Subfamily PTPRD 883-958 3.7e-18 60.5 In-house 205-280 (564) alignment
Range on Protein: 883-958
Range on HMM: 205-280/564.0
SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 |... .  . |..||||||.||||. | .|  |  ... . |    .|...| ||  |||. .|| |. | |  |
kvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea

subfamily_PTPN6_pd Subfamily PTPN6 883-965 3.4e-17 57.4 In-house 218-302 (306) alignment
Range on Protein: 883-965
Range on HMM: 218-302/306.0
SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDI---VRTMRDQRACMVQNVSQYRFVCECIcAAYMKISRS
  ... .| . |..||||||||||| .|..|. | |.| .   ...||   |...|.||  .||  .||.|| . | ..|.. ...
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyietkkk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 883-963 7e-10 33.1 In-house 217-296 (301) alignment
Range on Protein: 883-963
Range on HMM: 217-296/301.0
SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIcAAYMKIS
 .|.  .    ||.||||....|.|| . .. .|    |   |   ......| ..  .|.   || .. . |   |... 
vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmylqln

DSPc Dual specificity phosphatase, catalytic domain 883-953 8.1e-06 20.7 Pfam-A 65-129 (133) alignment
Range on Protein: 883-953
Range on HMM: 65-129/133.0
SVHQCiSAANPPVIVHCSAGIGRTGVLIL---MDT-ALALMEAREPVypldivrtmRDQRACMVQNVSQYRFVCE
 ....  . .  |.||| ||| |.. ||.   |.|  | | || | |         ...| ....|... | ..|
fieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv.........kerrskispnagflrqLle

DSPc Dual specificity phosphatase, catalytic domain 883-953 8.1e-06 20.7 In-house 65-129 (133) alignment
Range on Protein: 883-953
Range on HMM: 65-129/133.0
SVHQCiSAANPPVIVHCSAGIGRTGVLIL---MDT-ALALMEAREPVypldivrtmRDQRACMVQNVSQYRFVCE
 ....  . .  |.||| ||| |.. ||.   |.|  | | || | |         ...| ....|... | ..|
fieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv.........kerrskispnagflrqLle

subfamily_PTPRB_pd Subfamily PTPRB 884-961 6.7e-21 69.6 In-house 208-287 (293) alignment
Range on Protein: 884-961
Range on HMM: 208-287/293.0
VHQCI--SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
|.. |  .|.. |..||||||.||||..| .|. |  .| .. |  . ||  .| .|...||...|| |. .|. .  .|
vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 884-957 1.7e-17 58.4 In-house 204-277 (288) alignment
Range on Protein: 884-957
Range on HMM: 204-277/288.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
|..  .|   |.|||||||.||||. | .|...  .|. . .  ...|  .| ||| .||...|| |. |..  
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

0049260 (Phosphotyrosine protein) phosphatases II 884-952 2.7e-17 58.3 In-house 81-143 (152) alignment
Range on Protein: 884-952
Range on HMM: 81-143/152.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALalmearEPVYPLDIVRTMRDQRACMVQNVSQYRFVC
.....   . ||.||||||.||||.|....  |        | ....|. .| .| ..|.| .|.||. 
ieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_PTPRN_pd Subfamily PTPRN 884-956 1.7e-12 41.6 In-house 216-289 (297) alignment
Range on Protein: 884-956
Range on HMM: 216-289/297.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEarEPVYPLDIVRT---MRDQRACMVQNVSQYRFVCECIC
| ..      |..||||.| ||||| ||.|  |. .     |  .||. |   .||||. .|.  .|..|.  ...
vnksyrGrscpivvhcsdGaGrtGvyilidlvlnrll..kGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 884-961 3.3e-10 33.9 In-house 210-286 (302) alignment
Range on Protein: 884-961
Range on HMM: 210-286/302.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIcAAYMK
|..  . |. ....    |.|| |... . .|.  ... . .   .||...| ||...|....|| ..  .. . |.|
vfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial.llyik

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 884-961 1.6e-09 31.7 In-house 214-290 (302) alignment
Range on Protein: 884-961
Range on HMM: 214-290/302.0
VHQCISAaNPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
.. | |     |.||||||.|||| |. .   . |   ..    |.||  .|. |   ||. .|  ..  |.  . |.
lkfcesy.kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 884-954 1.9e-06 21.7 In-house 192-264 (281) alignment
Range on Protein: 884-954
Range on HMM: 192-264/281.0
VHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL-DIVRTMR-DQRACMVQNVSQYRFVCEC
. . | |   | ..|||||.||.| |. .. ||  . ..  .  . .||  .|   ||. || . || .. . 
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkv

subfamily_PTPN12_pd Subfamily PTPN12 885-958 1.4e-17 58.5 In-house 200-276 (290) alignment
Range on Protein: 885-958
Range on HMM: 200-276/290.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREP---VYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
..  .. . |..||||||.||||..| .| .  |..|.     .   |.|...| |||..||   ||..| ...   
relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Ptp69D_pd Subfamily Ptp69D 885-960 1.9e-14 48.5 In-house 212-287 (307) alignment
Range on Protein: 885-960
Range on HMM: 212-287/307.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYM
..  .  . |..|||||| ||.|... .|  |  ..| . |   ..|. .| ||  .||.  || |.   .    .
relyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 885-959 3.8e-13 44.0 In-house 205-279 (315) alignment
Range on Protein: 885-959
Range on HMM: 205-279/315.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
.|   ..  ...||||||.|||| .| .|. |  .|| . .   .... .|..|  ||| . ||.|. . .  ..
kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 885-959 1.3e-12 42.0 In-house 214-289 (305) alignment
Range on Protein: 885-959
Range on HMM: 214-289/305.0
HQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL-DIVRTMRDQRACMVQNVSQYRFVCECICAAY
  .|  .. |..||||||||||| .. ..  |  .    |. |. ..|...|||||  .||  || |.   .   .
lsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_PTPRA_pd Subfamily PTPRA 886-959 5.2e-17 56.7 In-house 222-295 (330) alignment
Range on Protein: 886-959
Range on HMM: 222-295/330.0
QCISA-ANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
..    |. |..||||||.|||| .| .|. |. ..| . |   ..|. .| ||. |||   || |. . .   |
klnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 886-956 4.5e-08 27.5 In-house 198-268 (288) alignment
Range on Protein: 886-956
Range on HMM: 198-268/288.0
QCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
. . . . |..||.|||.|||| |||.  ||  .   . .    ..  .|..|   .|   || .|  |. 
evlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_PTPN1_pd Subfamily PTPN1 887-966 5.9e-14 46.5 In-house 196-278 (290) alignment
Range on Protein: 887-966
Range on HMM: 196-278/290.0
CISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVR---TMRDQRACMVQNVSQYRFVCECICAAYMKISRSS
..|    |...||||||||.| ..|.|| |.|.|... .  .|| .    .| .|  ..|   | ||    |     .| ..|
slssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgds

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 887-957 2.7e-12 41.3 In-house 187-257 (267) alignment
Range on Protein: 887-957
Range on HMM: 187-257/267.0
CISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 .  .|.|..|.||.|.||.| .. .|. |  .   . .   | .| .|.||  .|.   .| .. | .. 
qlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_PTPN13_pd Subfamily PTPN13 888-957 2.2e-19 64.8 In-house 198-267 (273) alignment
Range on Protein: 888-957
Range on HMM: 198-267/273.0
ISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
.   . |..|||||||||.|.|| .|..| |.|  ...   .|||..|.||  .||   || || . |  
lqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 888-958 3.5e-16 54.2 In-house 212-283 (297) alignment
Range on Protein: 888-958
Range on HMM: 212-283/297.0
ISAANP-PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 |  .  |..|||.||.||||||. .|  .| ..  . |  ...|. .|..|  .||   ||.|| . .  |
fsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 888-955 7.7e-12 39.4 In-house 212-279 (290) alignment
Range on Protein: 888-955
Range on HMM: 212-279/290.0
ISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
.  |. ||.||||||||||| .. ....| ..     . .||.||..|. |.  ||   ||  . | .
lrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

subfamily_PTPN14_pd Subfamily PTPN14 889-963 1.4e-19 65.2 In-house 226-299 (300) alignment
Range on Protein: 889-963
Range on HMM: 226-299/300.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICaAYMKIS
  ..|||.||||||.|||||||| |  .| .|  | .    .....| ||  .||...||.|| . .   |.| |
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli.kylkns

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 889-959 2e-17 58.3 In-house 204-276 (281) alignment
Range on Protein: 889-959
Range on HMM: 204-276/281.0
S-AANPPVIVHCSAGIGRTGVLILMDTALALMEA-REPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY
.   . |...|||||.||||. | .|...  .|| .|.. . ..|. .| .|  ||| | ||.||   .  | 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 889-958 8e-17 56.3 In-house 210-279 (318) alignment
Range on Protein: 889-958
Range on HMM: 210-279/318.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
.. . |..||||||.||||| | .|. |  ..| . |  ...|...|.||  |||  .|| |. . .  |
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea

subfamily_PTPN9_pd Subfamily PTPN9 889-955 1.3e-16 55.5 In-house 220-286 (297) alignment
Range on Protein: 889-955
Range on HMM: 220-286/297.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
 . .||..||||||||||| .| .| .|. .|  . |   . |...| ||| ..|   || |   ..
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 889-958 3.1e-13 44.6 In-house 220-289 (298) alignment
Range on Protein: 889-958
Range on HMM: 220-289/298.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 | | ||||.||||.||.|  | .|. |  ... . |  ...|...| .|. .||  .|| |. | .  |
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 889-958 2.2e-11 37.8 In-house 124-193 (440) alignment
Range on Protein: 889-958
Range on HMM: 124-193/440.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 |.| |..|||||| |||||.| .|. |   .  . .  . .. .||..|  |||   || || |..  .
kagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavleg

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 889-956 2.9e-11 37.7 In-house 259-341 (350) alignment
Range on Protein: 889-956
Range on HMM: 259-341/350.0
SAANPPVIVHCSAGIGRTGVLILMDTALA----LMEAREPVYPL-----------DIVRTMRDQRACMVQNVSQYRFVCECIC
.|  .|..||||||.||||.|. .|  |     | . ..    |            ||  .| ||  ||||. |. |. |.. 
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

0038934 (Phosphotyrosine protein) phosphatases II 889-952 4.2e-08 28.6 In-house 111-170 (194) alignment
Range on Protein: 889-952
Range on HMM: 111-170/194.0
SA-ANPPVIVHCSAGIGRTGVLIlmdtALALMEARePVYPLDIVRTMRDQRACMVQNVSQYRFVC
.. ..  | ||| ||.||||.|.    | .|.. .    . . ....|. |  ...|..... ..
nedpggvvaVHCkaGlgRtGtlv....aaYLiyrl.gmsaeeAialfrekRpgaipnqdyleall

subfamily_egg_pd Subfamily egg 889-966 2.6e-06 21.3 In-house 198-277 (307) alignment
Range on Protein: 889-966
Range on HMM: 198-277/307.0
SAANPPVIVHCSAGIGRTGVLILMDTALALMeAREPVYPLDIVRT---MRDQRACMVQNVSQYRFVCECICAAYMKISRSS
  .  ||.|..  |. ....|. ...||  .  | |..   . |.   .| .|   |. | .| ||   .   .  .  |.
rnlskpvvvqdilGvskaatlvaieiallsl.lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 890-956 1.4e-19 65.1 In-house 196-261 (270) alignment
Range on Protein: 890-956
Range on HMM: 196-261/270.0
AANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
 |. |..||||||.||||.||..|.|. |.| .. | .| |.. .| .|  .|| . ||.|. . . 
kae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_PTPRK_pd Subfamily PTPRK 890-958 3.5e-14 47.3 In-house 208-276 (314) alignment
Range on Protein: 890-958
Range on HMM: 208-276/314.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
  . ...|||||| ||||. | .|. | ..| .. |    .|.|.|...  ||.   ||.|. . |  |
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 890-960 8.3e-14 46.1 In-house 214-284 (290) alignment
Range on Protein: 890-960
Range on HMM: 214-284/290.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYM
  | ...||||...||..|.. ..|..  ..    .  .......| |.  .|| | ||..... .  .  
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_PTPN23_pd Subfamily PTPN23 890-957 1e-13 45.8 In-house 210-278 (288) alignment
Range on Protein: 890-957
Range on HMM: 210-278/288.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP-LDIVRTMRDQRACMVQNVSQYRFVCECICA
 .. |..||||||.|||||. |. .|.. .|... .   ...|...| ||  |||...|..|. | .  
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 890-958 9.5e-13 42.9 In-house 173-241 (250) alignment
Range on Protein: 890-958
Range on HMM: 173-241/250.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
| | ||||.||||.||.|  | .|. |  ..  . |   ......| .|  .|.  .|| || | |  |
agnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 890-957 1.5e-12 42.1 In-house 209-276 (287) alignment
Range on Protein: 890-957
Range on HMM: 209-276/287.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
 .| ...||||...||..... ..|..   .    .  ..... .| |.  .|| |.||.|... . .
rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 890-957 5.7e-10 33.4 In-house 207-274 (312) alignment
Range on Protein: 890-957
Range on HMM: 207-274/312.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
  . ||| |||||.|||| |.|... .| .         |.   .| .||  |. . || ..  |.  
kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 890-956 1.9e-09 31.3 In-house 263-341 (349) alignment
Range on Protein: 890-956
Range on HMM: 263-341/349.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEARE-PVY-------PLD----IVRTMRDQRACMVQNVSQYRFVCECIC
.  ....|||||| ||||||. .|  |...|  .             |    || ..| ||  ||||..|. .. |.. 
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 890-955 1e-08 29.5 In-house 207-273 (307) alignment
Range on Protein: 890-955
Range on HMM: 207-273/307.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP-LDIVRTMRDQRACMVQNVSQYRFVCECI
  . ||.||||||.||.| .. .      | | .      ..|. .|.||   .|.  || ..   .
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 890-951 1.6e-07 25.4 In-house 212-273 (301) alignment
Range on Protein: 890-951
Range on HMM: 212-273/301.0
AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFV
 .. |..|||||||||.  .|  .     .||   .   . .. .|..| . ||..||  ..
ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 891-958 1.4e-16 55.5 In-house 215-282 (319) alignment
Range on Protein: 891-958
Range on HMM: 215-282/319.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
 . |..||||||.||||  | .| .|  ..  . .    .|...| || .|||. .||.|. | . .|
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 891-955 4.7e-13 43.7 In-house 198-262 (283) alignment
Range on Protein: 891-955
Range on HMM: 198-262/283.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
 . |..||||.|||||.|.| . ...  . .   |    .|. || ||  .||.  ||..| | .
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 891-955 3.1e-12 41.0 In-house 227-291 (297) alignment
Range on Protein: 891-955
Range on HMM: 227-291/297.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
 | ...||||||.||.||..| |. || .  .       |.. .|.||| .|| . |. .. . .
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 891-952 3.2e-10 34.6 In-house 173-233 (239) alignment
Range on Protein: 891-952
Range on HMM: 173-233/239.0
ANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
|  | ..|||||.|||| ....|. |   . .. |  .. |...|..|  |||   || |. 
ar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 891-952 4.3e-10 34.2 In-house 174-234 (239) alignment
Range on Protein: 891-952
Range on HMM: 174-234/239.0
ANpPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVC
|  | ..|||||.|||| ....|. |   . .. |  .. |...|..|  |||   || |. 
ar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 891-957 2.2e-09 31.5 In-house 218-285 (305) alignment
Range on Protein: 891-957
Range on HMM: 218-285/305.0
ANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPL-DIVRTMRDQRACMVQNVSQYRFVCECICA
.  |..||||||||||| .....  |  . | . .     |.. .|.||   .|   || || . |  
skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 892-957 2.3e-15 51.7 In-house 224-289 (319) alignment
Range on Protein: 892-957
Range on HMM: 224-289/319.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA
. ...||||||.||||| | .|. |  |.  . |   ..|| .|.||  .||.. || |.   .  
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 892-955 3.1e-15 51.1 In-house 216-279 (305) alignment
Range on Protein: 892-955
Range on HMM: 216-279/305.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
. |..||||||.||||| | .| ||  ... | |   ......| .|  |||.  || |. . .
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 892-958 3.6e-15 51.2 In-house 188-254 (284) alignment
Range on Protein: 892-958
Range on HMM: 188-254/284.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
. ...||||||.||||| | .|. |  |.  . |   ..|| .|.||  .||.. || |.   .   
ranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 892-956 1.7e-13 45.1 In-house 210-274 (315) alignment
Range on Protein: 892-956
Range on HMM: 210-274/315.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
. ...||||||.|||||.| .|  .| .. .. |  ...|...|..|  .||   .| |. . . 
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 892-955 3.2e-13 43.6 In-house 209-272 (515) alignment
Range on Protein: 892-955
Range on HMM: 209-272/515.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
. |.|.|||||.|||||.| .|  .| ..  . |  ...|. .|..|  .||   || |. . .
thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

subfamily_CG7180_pd Subfamily CG7180 892-961 5.4e-13 43.2 In-house 223-292 (296) alignment
Range on Protein: 892-961
Range on HMM: 223-292/296.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK
. ||.|..| | .|.|| . .| .| |.|  | |   . |.|.| .|  .|.|| .|... . .  |.. 
egPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 892-955 2.5e-09 31.7 In-house 172-235 (237) alignment
Range on Protein: 892-955
Range on HMM: 172-235/237.0
NPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
  | |.|||||.||||.....|. |   . .. |   . | .. ..|  ..|   || |. . |
sgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 893-960 2.2e-14 47.9 In-house 211-278 (287) alignment
Range on Protein: 893-960
Range on HMM: 211-278/287.0
PPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYM
 |..||...||||.|.|. . . .  .|    | .  .|  .| .||..|| | |.|...| . . | 
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 893-956 2.4e-13 44.3 In-house 213-276 (439) alignment
Range on Protein: 893-956
Range on HMM: 213-276/439.0
PPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECIC
 ||.||||||.|||| .| .| ||  . . . |    ||. .|.||  |||.. || |. ... 
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 894-955 2.1e-10 34.6 In-house 171-232 (392) alignment
Range on Protein: 894-955
Range on HMM: 171-232/392.0
PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECI
|.|.|||||.|||||.| .|. .|  .    |  ...|  .| .|  |||   || |.  ..
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_PTPDC1_pd Subfamily PTPDC1 894-953 3.3e-06 21.7 In-house 116-170 (182) alignment
Range on Protein: 894-953
Range on HMM: 116-170/182.0
PVIVHCSAGIGRTGVLIlmdtALALMEArEPVYPLDIVRTMRDQRACMVQNVSQYRFVCE
 | ||| || |||||||    |  |. | . . . . ....|..|.  .|  .| ..| |
kvavhChaGlGrtGvli....acylvya.krltaekaiklvrskrpksiqtreqvelvke

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 896-958 9.4e-08 26.4 In-house 2-64 (69) alignment
Range on Protein: 896-958
Range on HMM: 2-64/69.0
IVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
.||||.| |||| .| .   .| . .   |  .. |. ||  |  || |  .| |. . .  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 896-958 1.1e-07 26.1 In-house 1-63 (69) alignment
Range on Protein: 896-958
Range on HMM: 1-63/69.0
IVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA
.||||.| |||| .| .   .| . .   |  .. |. ||  |  || |  .| |. . .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea