Gene csw in Drosophila melanogaster

Synonym: 19-106, CG3954, CSW, Csw, Csw/Shp2, Dmel\CG3954, E(sev)1A, EG:BACN25G24.2, SHP-2, Shp-2, Shp2/csw, anon-WO03040301.207, anon-WO03040301.209, anon-WO03040301.219, csw/SHP-2, l(1)2Db, l(1)2Dd, l(1)G0170, l(1)GA114, l(1)csw, Dmel_CG3954, csw

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP045_AA protein Get Run
DmelP045_AA_317-747 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 211-286 1.1e-28 89.7 Pfam-A 1-77 (77) alignment
Range on Protein: 211-286
Range on HMM: 1-77/77.0
WFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKK-YDVGGGESFGTLSELIDHY
|.||..|..|||.|.||..|.|.||||||.|||||..|||..|.||.|. |. .... | . ..|.| .|.||..||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 313-390 1.1e-10 35.5 In-house 7-82 (392) alignment
Range on Protein: 313-390
Range on HMM: 7-82/392.0
AGINARVEQLV-KGGFWEEFESLQQdsRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYIR
| . | ||.      | |||  | .   | . .. . |. |  ||||.|||||| .|||| .|   ..  .|.|| ||.
aqfpafveknrhsalffeefhdlpg..pdiypqtvaqkeinlkknryknilpydsarvkl.eviddipdsdylnasyip

subfamily_PTPN9_pd Subfamily PTPN9 315-389 1.8e-08 28.8 In-house 6-78 (297) alignment
Range on Protein: 315-389
Range on HMM: 6-78/297.0
INARVEQLVKGGFWEEFESLQQDSR-DTFSRNegYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYI
. | |..  | |  .|.. ... .   || .    .. |  |||| ..| ||.|||.|  |..    ..|||||..
lvayvkekgkrGlskeyaeirnepveGtflas..klranleknrytdvlcydetrvvlakvded.easdyinanfv

subfamily_PTPN6_pd Subfamily PTPN6 316-394 1.7e-26 88.0 In-house 17-94 (306) alignment
Range on Protein: 316-394
Range on HMM: 17-94/306.0
NARVEQLVKGGFWEEFESLQQ-DSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLdvEHSVAGAEYINANYIRLPTD
.   |.| | ||.||||.||| ......||.|| |.||. ||||.||||.|||||.|   |.||.|..|||||||.  . 
ekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevk

subfamily_PTPRA_pd Subfamily PTPRA 316-390 8.8e-11 36.2 In-house 24-95 (330) alignment
Range on Protein: 316-390
Range on HMM: 24-95/330.0
NARVEQLVKgGFWEEFESLQQ-DSRDTFSRneGYKQENRLKNRYRNILPYDHTRVKLLDVeHSVAGAEYINANYIR
. |. .  |  | |||..|   . . |.      |.||. |||. ||||||..|| |  . . |  ..|||| .| 
rirsaddnk.lfreefnalPagpiqatlel..askeenkeknrvvnilPydfsrvilsvk.eGveesdyinasfid

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 317-389 9.3e-16 52.8 In-house 9-82 (318) alignment
Range on Protein: 317-389
Range on HMM: 9-82/318.0
ARVEQLVKGG---FWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYI
 .|..| . |   . ||.| |..... |... .  .. |. |||| |||.|||||||| ..| .. |..|||||||
shvrrlresGelllseeyerlsrsee.tvtslkslepvnkaknryanilaydhtrvkLqmle.geegsDyinanyi

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 317-390 1.3e-14 49.0 In-house 13-84 (288) alignment
Range on Protein: 317-390
Range on HMM: 13-84/288.0
ARVEQLVKGGFWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
|. ..  . || ||..|| .  . | | . | . .|  |||||||||||..|||| ..|  .|||.||||.|| 
akksarnrtgfseeynsLaalek.tksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyid

0050432 (Phosphotyrosine protein) phosphatases II 318-392 5.9e-17 57.4 In-house 27-102 (308) alignment
Range on Protein: 318-392
Range on HMM: 27-102/308.0
RVE--------QLVKGGFWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLldvehSvAGAEYINANYIRLP
.|.        .| .|...|||| |..     .... ....||. ||||..||||||.||||     .  |  ||||.|....
svldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....d.egsdYInAsyvdgy

0036941 (Phosphotyrosine protein) phosphatases II 319-393 5.4e-15 50.9 In-house 7-75 (297) alignment
Range on Protein: 319-393
Range on HMM: 7-75/297.0
VEQLVKGGFWEEFESLqQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLldvehSVAGAEYINANYIRLPT
 ..| . ....|||.| ..    .|.. . ..||. ||||..|||||||||||     .  |  ||||.|. .. 
ekllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgyd

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 319-390 9.6e-12 39.7 In-house 21-93 (298) alignment
Range on Protein: 319-390
Range on HMM: 21-93/298.0
VEQLVKGGFWEEFESLQQDSR--DTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
 ..    |. .||. |.. |   .... . . |.||. |||| .|...|..|| | ... .   ..|||| .. 
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflh

0040438 (Phosphotyrosine protein) phosphatases II 320-393 1.2e-15 53.0 In-house 13-83 (317) alignment
Range on Protein: 320-393
Range on HMM: 13-83/317.0
EQLVKGGFWEEFESLQQDSRDtfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPT
 .. .....|||| |.. . |  ........||. ||||..||||||.|||| ...  . .  ||||.|.  | 
lksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpn

subfamily_PTPN3_pd Subfamily PTPN3 320-395 1.1e-11 39.2 In-house 10-79 (280) alignment
Range on Protein: 320-395
Range on HMM: 10-79/280.0
EQLVKGGFWEEFESLQQDSRDtFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhsvAgaEYINANYIRLPTDG
|.| .|    .|| | .  ..  . ..  | ||  |||||.|||||.||||| . |   .  .||||||. .  ..
eglesGavlaqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklkese...t..dyinanyvnmeips

subfamily_PTPN14_pd Subfamily PTPN14 320-396 1.7e-10 35.4 In-house 18-91 (300) alignment
Range on Protein: 320-396
Range on HMM: 18-91/300.0
EQLVKGGFWEEFESLQQDSRDTFSrNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvaGAEYINANYIRLPTDGD
..| .|  . |.| ... . |.   . .  .||  |||....|||...||.|   ...    .||||  |. .  | 
kkleegkvfteyeripkkredall.staklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggk

0039614 (Phosphotyrosine protein) phosphatases II 321-748 2.3e-82 272.1 In-house 28-291 (297) alignment
Range on Protein: 321-748
Range on HMM: 28-291/297.0
QLVKGGFWEEFESLQQDSRDtfsRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDgdlynmsssseslnssvpscpactaa
.. |.....|||.|..   |   . .....||. ||||..||||||.|||| ...... .  ||||.|.  .                            
ansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl..........................

qtqrncsncqlqnktcvqcavksailpysncatcsrksdslskhkrsessassspssgsgsgpgssgtsgvssvngpgtptnltsgtagclvgllkrhsn
                                                                                                    
....................................................................................................

dssgavsismaerererereMFKTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWPDEGRseQFGHARIQCVSENSTSDYTL
                    . ...|||||.    . .|| |||.|||.....|||| ||. |.|. |||.|||.||   ..|. .. ....   ..||.
....................ltrkfIatqgP....lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytv

REFLVSWrDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQM
|.. |.  ... | . |...  ||||||| ..  .|.||. |......|    .|.||..||||||.|||||||.....|.|. ..    ..|.. ....
rtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavke

VRSQRSGLVQTEAQYKFVYYAVQHYIQT
.|.||.| |||. ||.|.|.|.......
lreqRpgavqtpsqyrflydallellkr

0047943 (Phosphotyrosine protein) phosphatases II 321-393 1.2e-15 53.2 In-house 8-74 (273) alignment
Range on Protein: 321-393
Range on HMM: 8-74/273.0
QLVKGGFWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLldvehSVAGAEYINANYIRLPT
.| .....|||| |..     .... ....||. ||||..||||||.||||     .  |  ||||.|.... 
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgyn

subfamily_PTPN13_pd Subfamily PTPN13 321-400 1.2e-14 49.2 In-house 7-79 (273) alignment
Range on Protein: 321-400
Range on HMM: 7-79/273.0
QLVKGGFWEEFESLQQdSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsvagaeYINANYIRLPTDGDLYNM
.| ..   |||. |..  . . . ..| |.||. ||||||.||||.||||| |         ||||..|..| . | |..
kldqqqPaeefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyey

0043336 (Phosphotyrosine protein) phosphatases II 322-393 2.3e-14 49.0 In-house 17-85 (278) alignment
Range on Protein: 322-393
Range on HMM: 17-85/278.0
LVKGGFWEEFESLQQDSRdtFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYIRLPT
 .| ....|||.|..     .... ....||. ||||..||||||.|||| ... .. .  ||||.|. .. 
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvkl.sllggdldsdYinAsyvdgyn

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 322-391 9.7e-10 32.9 In-house 21-87 (315) alignment
Range on Protein: 322-391
Range on HMM: 21-87/315.0
LVKGGFWEEFESLQQDSRDTFsrNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIRL
  | || ...||.       .  .   | ||. |||| ||..||..||.|  .|    ...|.|||.|  
stkngfkqdyesipggqlhpl..dvakkienkqknryiniiaydksrvqlpllend.phsdyvnanfidG

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 322-390 3.5e-06 20.9 In-house 12-79 (301) alignment
Range on Protein: 322-390
Range on HMM: 12-79/301.0
LVKGGFWEEFESLQQDSRDTfsRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEH-SVAGAEYINANYIR
  . .| |....|.. . ..   . |...||.  ||..|| .||. |. |   .. ...  |||||.|| 
khsnkfeeqykelkegedks..ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 323-390 8.5e-09 29.7 In-house 18-85 (290) alignment
Range on Protein: 323-390
Range on HMM: 18-85/290.0
VKGGFWEEFESLQQdSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDV-EHSVAGAEYINANYIR
 . || ..|..|.. .   .. . |  ..|.|.||..||..||  |. | .. .|     ||||| || 
gnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik

0045450 (Phosphotyrosine protein) phosphatases II 324-392 2.9e-17 58.8 In-house 26-95 (307) alignment
Range on Protein: 324-392
Range on HMM: 26-95/307.0
KGGFWEEFESLQQDSRD-TFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
. |...|||.|..   .  .........||. ||||..||||||||||| ....|. .  ||||.|.|.|
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvp

subfamily_PTPRD_pd Subfamily PTPRD 324-389 7.4e-17 56.2 In-house 22-84 (564) alignment
Range on Protein: 324-389
Range on HMM: 22-84/564.0
KGGFWEEFESLQQDsrDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYI
.  | ||......   ..|. ..  |..|. |||| ||..|||.||.|  ||    | .||||..|
dlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfi

0051299 (Phosphotyrosine protein) phosphatases II 324-395 1.6e-16 56.1 In-house 22-91 (288) alignment
Range on Protein: 324-395
Range on HMM: 22-91/288.0
KGGFWEEFESLQQDSRDtFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPTDG
. |..|||| |..   | .... ....||. ||||..||||||.|||| ...  | |  ||||.||...  .
ltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlk

subfamily_PTPRG_pd Subfamily PTPRG 324-389 1.8e-13 44.6 In-house 18-84 (563) alignment
Range on Protein: 324-389
Range on HMM: 18-84/563.0
KGGFWEEFESLQQDSRDT-FSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYI
. || ||||.||. . .. .  .   |.||. |||| ||..||..|||| ..       .|||||||
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyi

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 324-390 3.9e-13 44.1 In-house 14-78 (281) alignment
Range on Protein: 324-390
Range on HMM: 14-78/281.0
KGGFWEEFESLQQDSRDTFSRnEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVaGAEYINANYIR
. || ||.|.|..  .|  ..   ...||.|||||.||  ||.||||. . |..   ..|||||.. 
naGfieeyeklaaigvdntat.askadenvlknrYsnivaYDatrvkvtpneenk.ntDYinanfvp

subfamily_PTPRK_pd Subfamily PTPRK 324-394 4.6e-11 37.1 In-house 18-80 (314) alignment
Range on Protein: 324-394
Range on HMM: 18-80/314.0
K---GGFWEEFESLQQDsrdtfsRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIrlptD
.    || ||.||| .        .   |.||| |||. .||.||..||.|  ..   . ..||||..|    |
raegygfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgd.pssdyinaali....d

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 324-389 1.8e-07 25.4 In-house 19-79 (287) alignment
Range on Protein: 324-389
Range on HMM: 19-79/287.0
KGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsvagaEYINANYI
. || . |  |.| ...  .   .  ..|. |||...||..|  || | . ..     .|||| .|
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehp.....dyinavfi

subfamily_PTPRB_pd Subfamily PTPRB 325-390 1.3e-14 48.9 In-house 25-88 (293) alignment
Range on Protein: 325-390
Range on HMM: 25-88/293.0
GGFWEEFESLQQDSRDTfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIR
 .| ||.|.|..  .|. . .   ...|| ||||.|||||||.|||| ....  .|..|||||||.
lrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkd.esgsDYinanyip

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 325-389 1.5e-14 48.8 In-house 23-84 (319) alignment
Range on Protein: 325-389
Range on HMM: 23-84/319.0
GGFWEEFESLQQDSRDTFSrnEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYI
 .. .||. |.. . |||.  .  |.||. ||||.|||.||.|||.| ...  | |..||||..|
tllekefkllkeavndtfd..saskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfi

subfamily_Ptp69D_pd Subfamily Ptp69D 325-390 6.3e-14 46.8 In-house 22-85 (307) alignment
Range on Protein: 325-390
Range on HMM: 22-85/307.0
GGFWEEFESLQQDsRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIR
 |. .|.|.|..      | . . |.|| ||||| .| ..|.|||||  ..   . ..||||..|.
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkking.kedsdYinasfik

subfamily_PTPN23_pd Subfamily PTPN23 325-390 1.5e-08 28.8 In-house 15-76 (288) alignment
Range on Protein: 325-390
Range on HMM: 15-76/288.0
GGFWEEFESLQQ-DSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLdvehsVAGAEYINANYIR
... ..|. |.| . ... .|     . .  |||.|.||||||.||||          .|||| ...
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 325-391 2e-08 28.8 In-house 23-86 (325) alignment
Range on Protein: 325-391
Range on HMM: 23-86/325.0
GGFWEEFESLQqdSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLdVEHSVAGAEYINANYIRL
 ||  ||. |   | |. ...   | ||. |||..|....|..|| |    .  . ..||||.|.| 
dgfahefgllp..sddgiakkvamkpenkaknrfknvvaldksrvvle.tkkddpssdyinasylrd

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 325-390 3.7e-06 21.3 In-house 22-83 (305) alignment
Range on Protein: 325-390
Range on HMM: 22-83/305.0
GGFWEEFESLQQDsRDTFsrNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVaGAEYINANYIR
 |. ....||...  ...  . | |..|. |||...| ..|. |..|   |.    ..||||.|. 
kgleaqykslyee.eesi..dvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvd

0046845 (Phosphotyrosine protein) phosphatases II 326-392 3.2e-17 58.3 In-house 1-68 (284) alignment
Range on Protein: 326-392
Range on HMM: 1-68/284.0
GFWEEFESLQQDSRDTF-SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
|..|||| |..   . . |.. ....||. ||||..||||||.||||  ..... . .||||.|.. .
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 326-400 2.8e-11 37.7 In-house 11-84 (287) alignment
Range on Protein: 326-400
Range on HMM: 11-84/287.0
GFWEEFESLQQDSRD-TFSRNEGYKQENRLKNRYRNILPYDHTRVKLldVEHSVAGAEYINANYIRLPTDGDLYNM
   .|.. |..||.  |.   .  .  .  |||| ..||.|.||| |  ....  |..||||||.   || . .  
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvll..saegelGsdyinanyvasytddeafia

DSPc_SM00195 327-393 3.1e-16 54.9 In-house 2-66 (263) alignment
Range on Protein: 327-393
Range on HMM: 2-66/263.0
FWEEFESLQQDSRDTfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIRLPT
..||||.|..   .. . .|. |..|. ||||.|||||||||||| . |..  | .|||||||....
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgan

PTPc_SM00194 327-393 3.1e-16 54.9 In-house 2-66 (263) alignment
Range on Protein: 327-393
Range on HMM: 2-66/263.0
FWEEFESLQQDSRDTfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIRLPT
..||||.|..   .. . .|. |..|. ||||.|||||||||||| . |..  | .|||||||....
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgan

subfamily_PTPN12_pd Subfamily PTPN12 327-396 5.2e-15 50.1 In-house 10-83 (290) alignment
Range on Protein: 327-396
Range on HMM: 10-83/290.0
FWEEFESLQQDS-----RDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDvEHSVAGAEYINANYIRLPTDGD
| .||..|.. |      ...|...| |.||. ||||..|||||..||.|   .... | .|||||.|. ...  
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelsk.ieeeegsdYinanfikgvegkl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 327-391 9.9e-10 32.7 In-house 21-82 (315) alignment
Range on Protein: 327-391
Range on HMM: 21-82/315.0
FWEEFESLQQdsRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYIRL
| |||  | .   |.. .. . ...|  ||||.||||.|..|||| .|       .|||| ||. 
fseefhdlpd..PdiyrqrvaretinfkknryknilPldsarvkl.eviddsPdsdyinasyiks

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 327-390 3.8e-09 31.3 In-house 36-98 (319) alignment
Range on Protein: 327-390
Range on HMM: 36-98/319.0
FWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVeHSVAGAEYINANYIR
.. ||  . . . .   ..    ..|. |||. |||..|...|||  .   . ...|||| .. 
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerl.iGeefsdyinasfvt

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 327-402 1.2e-07 25.5 In-house 22-97 (439) alignment
Range on Protein: 327-402
Range on HMM: 22-97/439.0
FWEEFESLQQDSRDTFSRNEG-YKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIRLPTDGDLYNMSS
| |.||...  | |         .. .. ||||... ..||||| | ..   |  . |||||||.   | .||  . 
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip.gvphshyinanyikGyyddklyiatq

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 327-390 5.2e-06 20.7 In-house 8-66 (267) alignment
Range on Protein: 327-390
Range on HMM: 8-66/267.0
FWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvagaeYINANYIR
. .||| ... | ..      . ..|. .||. . ||||.||| | . |.      |||| |. 
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyve

subfamily_PTPN1_pd Subfamily PTPN1 328-394 1.4e-10 35.3 In-house 8-69 (290) alignment
Range on Protein: 328-394
Range on HMM: 8-69/290.0
WEE-FESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsvagaEYINANYIRLPTD
..| .. ......  |. .|  ..||| .||||.. ||||.|.|| . .      .||||. . |.  
ykeiyldirkeas.dfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslveleea

subfamily_ptpA1_pd Subfamily ptpA1 329-389 2.2e-10 34.9 In-house 25-83 (418) alignment
Range on Protein: 329-389
Range on HMM: 25-83/418.0
EEFESLqQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYI
|||  | ..|      .|| |. |  |||| |||| .||||.|  ..    |..|||||||
eefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd.kegsdyinanyi

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 329-390 4.5e-08 27.0 In-house 17-75 (244) alignment
Range on Protein: 329-390
Range on HMM: 17-75/244.0
EEFESLQQDSRDTFSRNeGYKQENRLKNRYRNILPYDHTRVKLLDVEhsVAGAEYINANYIR
||| .| . .|. .  |      |  |||| ||||.|.||| |   .    |..|||||||.
eefvglsdhtreflqtn.avlsanatknryinilpfdetrvilsssk..kegsdyinanyiq

subfamily_PTPRN_pd Subfamily PTPRN 329-389 2.2e-07 24.9 In-house 33-92 (297) alignment
Range on Protein: 329-389
Range on HMM: 33-92/297.0
EEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYI
.|.|.| .   .  ... . ...|  |||....|||||.|||| . | |    .||||  |
kewealcayeaepstkevakaeknvkknrskavlpydhsrvkl.keeasaeksdyinasai

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 343-390 1.8e-08 29.2 In-house 16-62 (284) alignment
Range on Protein: 343-390
Range on HMM: 16-62/284.0
SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVeHSVAGAEYINANYIR
 ..    ..|. |||. .||..|...|||  .   . ...|||| .| 
dqtfanldqnkdknrighilafdknvvklerl.iGeefsdyinasfit

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 343-390 2.3e-08 28.5 In-house 42-88 (297) alignment
Range on Protein: 343-390
Range on HMM: 42-88/297.0
SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
.     |. |  |.||.||||||  ||||  |...   ..|.|| ...
pqtvaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvk

0049772 (Phosphotyrosine protein) phosphatases II 343-392 2e-06 23.3 In-house 37-83 (314) alignment
Range on Protein: 343-392
Range on HMM: 37-83/314.0
SRNEGYKQENRLKNRYRNILPYDhTRVKLlDvEHSVAGAEYINANYIRLP
..  ... .|| |||| .|||.| .||.| .   .| |  ||||.|.. .
tilvadlflnrdknryldilpad.nrvil.p.glpvsgsdyinasyvdgf

0040439 (Phosphotyrosine protein) phosphatases II 344-393 1.1e-10 37.1 In-house 3-51 (249) alignment
Range on Protein: 344-393
Range on HMM: 3-51/249.0
RNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPT
.......||. ||||..||||||.|||| ...  . .  ||||.|| .. 
ysvallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyy

0045098 (Phosphotyrosine protein) phosphatases II 345-392 2.2e-11 39.1 In-house 26-62 (278) alignment
Range on Protein: 345-392
Range on HMM: 26-62/278.0
NEGYKQENRLKNRYRNILPYDHTRVKlldvehsvagaEYINANYIRLP
... . .|. ||||..||||||.|||           .||||.||. .
tpalylgnldknRykdilpydhsrVk...........dYINAsyidgy

0037934 (Phosphotyrosine protein) phosphatases II 346-402 1.7e-10 36.4 In-house 4-51 (243) alignment
Range on Protein: 346-402
Range on HMM: 4-51/243.0
EGYKQENRLKNRYRNILPYDHTRVKLldvehsvAGAEYINANYIRLPtdGDLYNMSS
 . ..||. ||||..||||||.||||        |  |||||.|. .  . |. .. 
iallpenlsknrysdilpydhsrvkl.......egsdyinanliyvt..prliatqg

0042113 (Phosphotyrosine protein) phosphatases II 346-393 1.9e-10 36.0 In-house 3-49 (245) alignment
Range on Protein: 346-393
Range on HMM: 3-49/245.0
EGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPT
 ....||. ||||..||||||||||| ....   .  ||||.|. .. 
vallpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyr

subfamily_CG7180_pd Subfamily CG7180 346-389 3e-06 21.1 In-house 36-78 (296) alignment
Range on Protein: 346-389
Range on HMM: 36-78/296.0
EGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYI
 |...||| |||. ...|||..|| |  ..   .  .|||| |.
gglrkenreknrdvkvvPyDynRvvLekldGe.eksdYinavyv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 347-401 3.5e-08 28.0 In-house 4-57 (250) alignment
Range on Protein: 347-401
Range on HMM: 4-57/250.0
GYKQENRLKNRYRNILPYDHTRVkLLDVEHSVAGAEYINANYIRLPTDGDLYNMS
. | .|. |||| .|...|..|| .|  |..   ..|||| ..   .. ... ..
akkpqnkeknryadiialdssrv.vLekekgdkesdyinasflhgyderkafiat

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 348-390 3.1e-08 27.2 In-house 39-80 (515) alignment
Range on Protein: 348-390
Range on HMM: 39-80/515.0
YKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
 .. |  ||||.|||||| .||||  ..      .|.|| ||.
qeeinfkknryknilPydsvrvklevin.dnPhsdyfnasyip

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 349-395 2.6e-09 31.4 In-house 30-73 (297) alignment
Range on Protein: 349-395
Range on HMM: 30-73/297.0
KQENRLKNRYRNILPYDHTRVKLLDVehsVAGAEYINANYIRLPTDG
..    |||||.|| .| |||||| |   ... .||||.|. .| . 
rnsslrknryrdilatddtrvkllrv...iterdyinadyvvfpdee

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 349-390 3.1e-06 21.5 In-house 5-45 (239) alignment
Range on Protein: 349-390
Range on HMM: 5-45/239.0
KQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
|. |. |||| ||. |||.|| |  .      ..||||.|.|
krvnkaknryanivtydhsrvvleklsnd.phsdyinasylr

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 349-390 3.8e-06 21.2 In-house 4-44 (239) alignment
Range on Protein: 349-390
Range on HMM: 4-44/239.0
KQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
|. |. |||| ||. |||.|| |  .      ..||||.|.|
krvnkaknryanivtydhsrvvleklsnd.phsdyinasylr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 350-390 2.2e-08 27.9 In-house 45-84 (440) alignment
Range on Protein: 350-390
Range on HMM: 45-84/440.0
QENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
 .|..|||||||| |||.|| | .|. .|  ..|||| || 
pnnkvknryrnilaydhsrvmleevk.gvpdsdyinasyin

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 350-392 1.1e-07 26.3 In-house 26-68 (274) alignment
Range on Protein: 350-392
Range on HMM: 26-68/274.0
QENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
  .  ||||..||| ...|| |   . .   ..|||||||. .
fgsqtknryktilPnensrvllesessededssyinanyikGy

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 351-395 1.6e-11 38.5 In-house 46-97 (350) alignment
Range on Protein: 351-395
Range on HMM: 46-97/350.0
ENRLKNRYRNILPYDHTRVKLL-------DVEHSVAGAEYINANYIRLPTDG
|   ||||.|||||.|.||||         ..||. . .||||||..|.  .
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfs

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 351-390 3.4e-08 27.8 In-house 19-57 (270) alignment
Range on Protein: 351-390
Range on HMM: 19-57/270.0
ENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
 ..  |||..|||  .|||.| ..|.    ..||||||.|
rgkklnRyadiLPsPatRvrleeleed.sataYinAnyvr

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 351-398 6.3e-07 23.8 In-house 2-45 (237) alignment
Range on Protein: 351-398
Range on HMM: 2-45/237.0
ENRLKNRYRNILPYDHTRVKLLDvehSVAGAEYINANYIRlPTDGDLY
||..|||| ||  |||.|| |     . .|..||||.|..   ||   
enkiknrygnivaydhsrvvlkg...agsgsdyinatylk.gfdgtpk

Y_phosphatase Protein-tyrosine phosphatase 352-392 1.5e-09 33.0 Pfam-A 1-38 (235) alignment
Range on Protein: 352-392
Range on HMM: 1-38/235.0
NRLKNRYRNILPYDHTRVKLldvEHSVAGAEYINANYIRLP
|. ||||..|||||.|||||   ..|    .||||||... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgy

Y_phosphatase Protein-tyrosine phosphatase 352-392 1.5e-09 33.0 In-house 1-38 (235) alignment
Range on Protein: 352-392
Range on HMM: 1-38/235.0
NRLKNRYRNILPYDHTRVKLldvEHSVAGAEYINANYIRLP
|. ||||..|||||.|||||   ..|    .||||||... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 352-392 2.4e-06 21.1 In-house 48-101 (349) alignment
Range on Protein: 352-392
Range on HMM: 48-101/349.0
NRLKNRYRNILPYDHTRVKLLDVEHSVAGA-------------EYINANYIRLP
   ||||..||||.|.||||    .| ...             .||||||..|.
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylklt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 512-748 8.6e-59 194.2 In-house 73-292 (298) alignment
Range on Protein: 512-748
Range on HMM: 73-292/298.0
VGLLKRHSNDSSGAVSISMAEREREREremfkTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVS
| | | .... |  .  | ..  ..|.     ..||||. |    ..||.||| ||..|.  .||| |.  | .| |. .|||||| .|..|. ...  |
vvLekedadeesdYiNAsflhaykgrn.....afiatqaPl....tetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvslls

ENSTSDYTLREFLVSWRD-QPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRnglDT
... .|.. |.. || .. .  |.. . || .|||.|||.    ||..|..|.. |.   |||.|  |. |.||||.||.||||.|| .|... .   . 
keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq...qagnk..pvivqCsaGvgRsGtfiaidsvlervkk...eq

EIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQT
 .|. ......| .| |.||||.||.|.|.||......
vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 518-742 4.3e-41 135.6 In-house 55-262 (283) alignment
Range on Protein: 518-742
Range on HMM: 55-262/283.0
HSNDSSGAVSISMaererEREREMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSD
.|.|   || | .     ... .  | ||..|. |     .|| ||| ||..|.   ||| ||  |  ..||..||| .| ||..|   .    | .   
esrdyinavfipv.....sksykqdkkyiiaqsPl....drtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsns

YTLREFLVSWR--DQPARRIFHYHFQVWpdhgVPADPGCVLNFLQDVNTRQSHlaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQ
.. .|.|.      . .  . || .. |    .  ... ..| |  .|  .|   |  .| ||| ||||.|||||..|| .   ....  . .   .|. 
fiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvisl..qteskkgPivvhCstgiGrtavfiaasasvkdaltesv...vdvf

RTIQMVRSQRSGLVQTEAQYKFVYYAV
 .....| || ..|||  |||.|. .|
avvkimreqrmmavqtldqyklvhelv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 533-615 2.9e-12 41.0 In-house 96-170 (350) alignment
Range on Protein: 533-615
Range on HMM: 96-170/350.0
REREREREMfkTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQfgHARIQCVSENST
   | . .    |||||. |     .|| ||.... . . .||.. |.. | . ||| |||.. . ...  . ...   || .
fsveinpdf..kYiatqaPl....pstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsyddi..tvklaskwenim

subfamily_PTPN6_pd Subfamily PTPN6 536-753 3.3e-103 339.9 In-house 97-301 (306) alignment
Range on Protein: 536-753
Range on HMM: 97-301/306.0
EreremfKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVS--WRDQPAR
.      |.||||||||     .||.|||.||||||.|||||||||.|||||||||||||| ..|..|. ....|||.|..||.|||..||  .... .|
d......ksyiatqgcl....ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeer

RIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAgeKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEA
..|.|||..|||||||.|||.||.||.|||..|..|..|  ..|||.|||||||||||||||||..|..| ..|||..||||.....||.|||||||||.
evfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteq

QYKFVYYAVQHYIQTliaRK
||||||.|...||.|   .|
qykfvykaikkyiet...kk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 537-614 2.6e-06 21.0 In-house 107-172 (349) alignment
Range on Protein: 537-614
Range on HMM: 107-172/349.0
ReremfkTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQfgHARIQCVSENS
.       |||||  |      || ||....  .. ....  ... | . ||| .|| .   |.   . ..|  |...
k......kyiatqaPl....PstvddfykvillngvklvlsLnddkelslekcdiywqelsysni..tvklqnsslyi

0050432 (Phosphotyrosine protein) phosphatases II 539-749 5.8e-73 241.2 In-house 73-302 (308) alignment
Range on Protein: 539-749
Range on HMM: 73-302/308.0
R-------------------------------EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE--GRSEQFGHA
|                                  ...|||||.|     ||| ||| |||..|.||||| ||..|.|.||||.|||.|  | |...|. 
rykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPl....pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkf

RIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqageKPGPICVHCSAGIGRTGTFIVIDMILDQIV
.. ..|| . .|||.|.. ... .|.. |.. |.|.  ||||||| .|  .|.||. |....        ..|||.||||||.|||||||..|..|.|. 
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqle

RNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL
..    ..|.. .....|.|| | |||. ||.|.|.|...|....
ke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 540-748 6.2e-55 181.1 In-house 50-244 (250) alignment
Range on Protein: 540-748
Range on HMM: 50-244/250.0
EMfKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEkCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPAR-RIFHY
|  |..||||| |    ..|. ||| ||..|.. .||| |.  | .|. . .||| | ..|..|. ...  |..  .||| |.. .| . .  .  . ..
er.kafiatqgPl....qatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrql

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqAgeKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
|| |||| |||.   .||..|..|.. | .   |  . .|. |.||||.||.|.||.|| .|... .   .  .|. . |...| .| . |....|| ||
hfvvWPdkgvPevatavLellkkvqasqqq...a..gnaPvivqCsaGvgrsGafiaidavlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfv

YYAVQHYIQT
| ........
yeiilkalds

subfamily_PTPN3_pd Subfamily PTPN3 540-743 1.1e-54 180.3 In-house 81-272 (280) alignment
Range on Protein: 540-743
Range on HMM: 81-272/280.0
EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD-QPARRIFHY
.. . |||||| |     .|.||||.|||......||| |   |||. || .|||... . ..|. ...| .|..|. | |||.... .. .  |.|.. 
glvnryiatqGPl....aktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilql

HFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 .  ||||||| |.  .|.|.. |.. .        |  |. ||||||||||| .|.... |  | ..    .. .   ....| ||. ||||..|||||
qylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGigrtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfv

YYAVQ
  |. 
Ceail

subfamily_PTPN1_pd Subfamily PTPN1 540-749 2.3e-53 175.8 In-house 68-274 (290) alignment
Range on Protein: 540-749
Range on HMM: 68-274/290.0
EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR--SEQFG--HARIQCVSENSTSDYTLREFLVS-WRDQPARR
|. . || ||| |    .|||. ||.|||..... .||  |  |... |||.||| . .  . ..   . ... .||...| ||.| . .   . | .| 
eakrsyiltqGPl....pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetre

IFHYHFQVWPDHGVPADPGCVLNFLQDVntRQSHLAqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQ
|.|.|.  ||| |||  |.  |.||..|  |.|      .. ||  .||||||||.|||...| .| .| ...  . .||....  .|..| ||.||  |
ilhfhyttwpdfgvpespaaflkflfkv..resGsl..ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadq

YKFVYYAVQHYIQTL
 .| | |. . ....
lrfsylaileGakvi

subfamily_egg_pd Subfamily egg 540-753 1.1e-22 75.1 In-house 80-277 (307) alignment
Range on Protein: 540-753
Range on HMM: 80-277/307.0
EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERgkEKCARYWPD-EGRSEQF--GHARIQCVSENSTSDY--TLREFLVSWRDqpARR
 .. ..| .|  |     ||| ||| ||.||. . ||| |   |   |.|  |||  |  | ..  |  ||...  .|..|   .. .. .   |     
pllnefilaqapl....kntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..dee

IFHYHFQVwpDhgvpadpgcvLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgLDTEIDIQRTIQMVRSQRSGLVQTEAQ
 |  |.|   |          .|.. || .    | .. .   |. |..  |. ...|.. |.. | ...|    |   ..|.....| .|   |..  .
rflehwqg..d..........vnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvll

YKFVYYAVQHYIQTLIARK
| |||  |  ... .|.  
ylfvyrlvlfffrdvigsa

subfamily_PTPRB_pd Subfamily PTPRB 541-747 3.2e-62 205.2 In-house 92-286 (293) alignment
Range on Protein: 541-747
Range on HMM: 92-286/293.0
MFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWrDQPARRIFHYHF
. . .||||| |     .|| |||.|||......||| |.  |.||.|| .|||.. .. ..|. ... |.|....|...||....  ..  |.. .|||
sprefiatqGPl....petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhf

QVWPDHGVPADPGCVLNFLQDVNTRQSHlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. ||||||| ..  .|.|.. |......     .. .|| ||||||.||||||| .|..|..| .   .  .||  ... .|..|  |||||.|| |.. 
tsWpdhgvPektktlldfvrtvreaiek....taskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihq

AVQHYIQ
.|.....
cvldllr

0037934 (Phosphotyrosine protein) phosphatases II 541-746 6.2e-61 201.3 In-house 42-242 (243) alignment
Range on Protein: 541-746
Range on HMM: 42-242/243.0
MFKTYIATQGCLLTqqvnTVTD----FWNMVWQENTRVIVMTTKEYERGKEKCARYWPdegRSEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARR
.....||||| |      || |    ||.|.|.....|||| |...|.|.||||.|||    ....|. .....||....|||.|..|...   |.. | 
vtprliatqgPlpe....tveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrl

IFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQ--AGEKPGPICVHCSAGIGRTGTFIVIDMILDQIvrngldtEIDIQRTIQMVRSQRSG-LVQT
..|||.  ||||||| .|  .|.||..|.. .. | .  |  . ||..||||||.|||||.|.....|...       ..|.. .....|.||.|  |||
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqt

EAQYKFVYYAVQHYI
. ||.|.|.|.....
psqyrflyeallell

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 541-749 2.2e-57 189.2 In-house 71-271 (274) alignment
Range on Protein: 541-749
Range on HMM: 71-271/274.0
MFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS---EQFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFH
  |.|.|||| |    .|||.|||.|..||...||||.||  |. ..|||.|.||.      |..|.  |. .. ... ||..|.....   .  |.. |
eskayvatqGPl....pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkh

YHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKF
| .  |||| .| |.  .|.....|.. ..   .. .| .|. ||||||||||| || |.. . |. .   .. .|. ...  .| .| |.|||. ||..
ywytdWPdhksPddantlldlvleveesre...eenaklapvvvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyel

VYYAVQHYIQTL
.. |. .| . |
ihralclylkrl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 541-742 3.7e-41 135.9 In-house 49-236 (239) alignment
Range on Protein: 541-742
Range on HMM: 49-236/239.0
MFKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA-RRIFHYH
  |.|||||||. .    .  ||| |.|||   |||| |   |  |.|| .||||   . ..   |.     .  .|| .| |..|   |   | ...||
spkayiatqgcvei....ssgdfwrmmwqerrcvivmltglieghkkkchqywpds..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyh

FQVWPDHGVPADPGCVLNFLQDVnTRQShLaqAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
| ||||.|||    .|| . . . |..| |   | .  |  .|||||.||||.|.||| .| |  ..     .||   .. .| .|  .|||  || |..
ftvwpdkgvpqyatavlglrrki.tkds.l..pgar..pwvihcsagvgrtgaflvidamlrqakkq...ktvdifnyvkairedrphmvqtseqyvfih

YAV
 ||
lav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 541-742 4e-41 135.8 In-house 50-237 (239) alignment
Range on Protein: 541-742
Range on HMM: 50-237/239.0
MFKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA-RRIFHYH
  |.|||||||. .    .  ||| |.|||   |||| |   |  |.|| .||||   . ..   |.     .  .|| .| |..|   |   | ...||
spkayiatqgcvei....ssgdfwrmmwqerrcvivmltglieghkkkchqywpds..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyh

FQVWPDHGVPADPGCVLNFLQDVnTRQShLaqAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
| ||||.|||    .|| . . . |..| |   | .  |  .|||||.||||.|.||| .| |  ..     .||   .. .| .|  .|||  || |..
ftvwpdkgvpqyatavlglrrki.tkds.l..pgar..pwvihcsagvgrtgaflvidamlrqakkq...ktvdifnyvkairedrphmvqtseqyvfih

YAV
 ||
lav

0046845 (Phosphotyrosine protein) phosphatases II 542-749 1.1e-73 243.4 In-house 76-277 (284) alignment
Range on Protein: 542-749
Range on HMM: 76-277/284.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWR--DQPARRIFHYH
 |..||||| |     ||| |||.|||..|.||||| |.. |.|.||||.|||.|| . ..|. .. ..||.  .|||.|.. ...   ... |.. |.|
kkkfIatqgPl....pntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

FQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.  |||||||..|  .|.||..|.. ...     ...|||.||||||.|||||||..|..|.|. ..||....|.. .....|.|| | |||..||.|||
ytswpdhgvppspedlleflrlvrellen....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

YAVQHYIQTL
.|...|....
ealleylklk

DSPc_SM00195 542-747 1.8e-68 226.1 In-house 68-263 (263) alignment
Range on Protein: 542-747
Range on HMM: 68-263/263.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENSTS-DYTLREFLVSWRDQ-PARRIFHY
 |.||||||.|     .|| |||.|||.|....|||.|.| |.|||||.||||.| |..|.||. ....|...... ...||.. ..  ..  .|.. .|
kkkyIatQgPl....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFV
... ||||||| ..  ||..|. |....|.        |||.||||||.||||||..||.||... ..     .||. .....|.|| |.|||..||.|.
qyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfi

YYAVQHYIQ
| |. .||.
yeaileyik

PTPc_SM00194 542-747 1.8e-68 226.1 In-house 68-263 (263) alignment
Range on Protein: 542-747
Range on HMM: 68-263/263.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENSTS-DYTLREFLVSWRDQ-PARRIFHY
 |.||||||.|     .|| |||.|||.|....|||.|.| |.|||||.||||.| |..|.||. ....|...... ...||.. ..  ..  .|.. .|
kkkyIatQgPl....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFV
... ||||||| ..  ||..|. |....|.        |||.||||||.||||||..||.||... ..     .||. .....|.|| |.|||..||.|.
qyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfi

YYAVQHYIQ
| |. .||.
yeaileyik

0047943 (Phosphotyrosine protein) phosphatases II 542-746 8.9e-68 224.0 In-house 76-272 (273) alignment
Range on Protein: 542-746
Range on HMM: 76-272/273.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR--SEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHY
 ...||||| |     ||| |||.|||..|.||||| |...|.|.||||.|||.||   |...|. .. ..||.. .|||.|.. ...  ..  | . |.
krkfiatqgPl....pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthf

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAgekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFV
|.  |||||||...  .|.|...|.. ...| .     ||..||||||.|||||||..|..|||. ..|   ..|.  .....|||| | |||. ||.|.
hytgwpdhgvppslesllefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrfl

YYAVQHYI
|.|. .|.
yealleyl

0043336 (Phosphotyrosine protein) phosphatases II 542-746 1.2e-64 213.8 In-house 87-277 (278) alignment
Range on Protein: 542-746
Range on HMM: 87-277/278.0
FKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPdeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHF
 ...|||||.|      || |||.|||......||| |.. |.|..|||.|||  | |...|. .. ...|.. .|||.| . |.  .| . | . |||.
prkfiatqgPlpe....tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy

QVWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||||||| ..  .|.||..|.....       ..||..||||||.|||||||.....|.|. ..|   ..|.. .....|.|| | |||. ||.|.|.
lgwpdhgvpeslsllldflkavreale......dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflye

AVQHYI
|...|.
alleyl

0042113 (Phosphotyrosine protein) phosphatases II 542-746 2.9e-61 202.3 In-house 51-243 (245) alignment
Range on Protein: 542-746
Range on HMM: 51-243/245.0
FKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHF
 ...||||| |      || |||.|.|... ..||| |.| |.|..|||.|||. | | ..|. .....||.. .|||.|.. |.  .| . | ..|||.
tpkfiatqgPlpe....tvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

QVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||||||| ..  .|.||. |.. ..       ..||..||||||.|||||||.....|.|. ...   ..... .....||||.| |||. ||.|.|.
lpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflye

AVQHYI
|.....
allell

subfamily_PTPN12_pd Subfamily PTPN12 542-753 2.3e-60 199.0 In-house 82-284 (290) alignment
Range on Protein: 542-753
Range on HMM: 82-284/290.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQ-FGHARIQCVSENSTS-DYTLREFLVSWRdQPARRIFHYH
 ..|||.|| |     .|..||| |.|. |....||  .|.| || ||.||||.|| .|  ||. .... .|. .. |...| . |  . .  |..  .|
kleyiaaqgPL....pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfh

FQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.. |||||||. .  .|.....|...|.      ..  |..||||||.||||| |.||.. ... .. .. |.|.   .. .| ||. ||||. ||..||
YtaWPDhgvPssaksllelielvrelqe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvy

YAVQHYIQTLIARK
 || ...|. .. .
kavaelvqkeleii

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 542-744 3.6e-58 191.9 In-house 89-277 (288) alignment
Range on Protein: 542-744
Range on HMM: 89-277/288.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSwRDQPARRIFHYHFQ
 |.|||||| |     .|| |||..|....|  ||| |.  |.||.|| .||||... ...|.  .. |... . |..||..|.  ...  ..| .|...
kkkyiatqgPl....adtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqyl

VWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
.|||||||..   .|..|. |.. ..         ||| ||||||.|||||||..|...|.. .   .  ||.  |.. .| ||  ||||. || |.| .
aWpdhgvPeskapllellrqvkvanqad......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyev

VQH
. .
lls

subfamily_Ptp69D_pd Subfamily Ptp69D 542-747 2.5e-51 169.7 In-house 90-287 (307) alignment
Range on Protein: 542-747
Range on HMM: 90-287/307.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRD------QPARRI
.|..|| |. .     .|. ||| |... .  .||| ... |  ..|||.|||.|    |.|.  ...|||...|||. ||. ||  .      .  |..
kkkfiaaqdPv....eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkv

FHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVrngLDTEIDIQRTIQMVRSQRSGLVQTEAQY
  ||.. |.|  ||  .  .|.... |.  ...        .|| |||||| ||.|.|. .|..|.|.    .. ..||  |.. .||||. |||  .||
vqyhytgWkDskvPevargllklieqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlk...aedkvdifetvkdLrsqRnllvqsleqY

KFVYYAVQHYIQ
.|.| |.  |..
vflyralldyss

0041856 (Phosphotyrosine protein) phosphatases II 542-747 1.7e-39 130.7 In-house 33-172 (182) alignment
Range on Protein: 542-747
Range on HMM: 33-172/182.0
FKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTkeyergkekCARYWPdegrseqfghariqcvsenstsdytlreflvswrDQPARRIFHYHFQ
....||||| ||     || ||..|..... ..||. |         . .|||                                  .   | ...|.. 
atrfiatqgplls....tvadflrmlkelgittivnlt.........eelywp..................................ellerlgiqylyl

VWPDHGVPAdPGCVLNFLQDVNTrqshlaqageKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||||||  .  .|.|...|.           ..||. ||||||.|||||........ .        ..... ....|||.|.| |.|. || |...|
pwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmkkl........gvsleeavklvrsrRpgmvitpnqyfflqla

VQHYIQ
. ....
llelll

0049772 (Phosphotyrosine protein) phosphatases II 542-750 1e-31 106.2 In-house 83-284 (314) alignment
Range on Protein: 542-750
Range on HMM: 83-284/314.0
FKTYIATQGCLLtqqvNTVTDF----------WNMV--WQENTRVIVM---------------------TTKEYERGKEKCARYWPDEGrseqfghariq
|...||||| |     .|| ||          |.||  .. |.|.|||                      ..  ..| | .|.....             
flkfIatqgple....itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........

cvsenstsdytlreF-------LvswrdqpARRIFHYHFQVWPDHGVPaDPGCVLNFLQDVNTRqshlaqagEKPGPICVHCSAGIGRTGTFIVIDMILD
                      .        |....|.   .||...| ..  .. ||. ...         .|.||. |||.||.||||||.|..... 
..............eelydpelf.......erlgikylripvpDgsap.lledfdeflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmk

QIvrngldtEIDIQRTIQMVRSQRS-----GLVQTEAQYKFVYYAVQHYIQTLI
.         .... ....||..|.     |....  || |...|...|...|.
ll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_PTPRD_pd Subfamily PTPRD 543-749 2e-71 236.3 In-house 91-284 (564) alignment
Range on Protein: 543-749
Range on HMM: 91-284/564.0
KTYIATQGCLLtqqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVS-WRDQPARRIFHYHFQ
|.|||||| |     .|. ||| |||..|...||| ||  |.||.||..|||..| .|..|.  .. ..|.  .||..|.| ..  ... .| . ..|| 
kayIAtqgPla....etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFt

VWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||||||  .  .|.....|.. ..      .. ||| ||||||.||||||||||..|..|     .  .||  .....|.||  .|||| || |...|
sWPdhgvpesatslLdlirkvralne......pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFihea

VQHYIQTL
......  
ilealacg

0036941 (Phosphotyrosine protein) phosphatases II 543-750 3.1e-70 232.1 In-house 78-281 (297) alignment
Range on Protein: 543-750
Range on HMM: 78-281/297.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENS--TSDYTLREFLVSW-RDQPARRIFHY
...|||||.|     ||| ||| |||..|..|||| |...|.|.||||.|||.| | | ..|. .....|...   .|||||.. |.  .... |.. |.
rkfIatqgPl....pntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthf

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
|.  ||||||| .|  .|.|.. |......|     ..||..||||||.||.||||..|..|.|. ..    ..||  .....|.|| | |||. ||.|.
hytgwpdhgvpespaslldfielvrkvlkll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

YYAVQHYIQTLI
|.|.......  
yeallellkkkl

0040438 (Phosphotyrosine protein) phosphatases II 543-762 3.5e-70 232.1 In-house 86-292 (317) alignment
Range on Protein: 543-762
Range on HMM: 86-292/317.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHFQ
...|||||.|     ||| |||.|||.....|||| |.. |.|.||||.|||. | . ..|. .....||   ...|||.. |.  .|.. |.. |.|. 
rkfIatqgPl....pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhyt

VWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 ||||||| .|  .|.||. |.. ..      ...||..||||||.|||||||.....|.|. ..|   ..|.. .....|.||.| |||..||.|.|.|
gWpdhgvppspdllldfleavreale......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflyda

VQHYIQTLIARKRAEEQSLQV
...|... . .. | |. | .
lleylkrkltlepaselklkl

0051299 (Phosphotyrosine protein) phosphatases II 543-746 5.5e-70 231.4 In-house 92-286 (288) alignment
Range on Protein: 543-746
Range on HMM: 92-286/288.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-----RDQPARRIFH
...|||||.|     ||| |||.|||..|.||||| ||..|.|.||||.|||. | |...|. .. ..|| . .|||.|.. |.       |.  |.. |
rkfIatqgPl....pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvth

YHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKF
.|.  ||||||| .|  .|.||..|.. ..       ..||..||||||.|||||||..|..|.|. ..    ..|. ......|.|| |.|||. ||.|
fhytnwpdhgvpdspellldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrf

VYYAVQHYI
||.|. .|.
vyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 543-746 2e-67 223.4 In-house 107-304 (307) alignment
Range on Protein: 543-746
Range on HMM: 107-304/307.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYHF
...|||||.|     .|| |||.|.|.....|||| |.. |.|.||||.|||||| . ..|. .. ..||.  ..||.| . |.    ... |.. |.|.
rkfIatqgPl....petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

QVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||||||| ..  .|.|.. |.. ...|     |.||..||||||.|||||||.....|.|. ..|  . .|.. .....|.||.| ||.. ||.|.|.
tgwpdhgvppsfeelldfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

AVQHYI
|.....
allell

Y_phosphatase Protein-tyrosine phosphatase 543-743 1.1e-62 207.0 Pfam-A 42-234 (235) alignment
Range on Protein: 543-743
Range on HMM: 42-234/235.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCV-SEN-STSDYTLREFLVSWRDQPA--RRIFH
|..|||||.|     .|. ||| |||||...|||| |.. |.|.||||.||| .|..|...|. ..... .|.  ...||||.. .. ....   |.. .
kkfIatQgPl....kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkq

YHFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKF
.|.. |||||||..|  .|.....|....       .| ||..||||||.||||||...|..|.|. ...    .|.  .....|.|| |.||...||.|
lhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYif

VYYAVQ
.| |..
lykail

Y_phosphatase Protein-tyrosine phosphatase 543-743 1.1e-62 207.0 In-house 42-234 (235) alignment
Range on Protein: 543-743
Range on HMM: 42-234/235.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCV-SEN-STSDYTLREFLVSWRDQPA--RRIFH
|..|||||.|     .|. ||| |||||...|||| |.. |.|.||||.||| .|..|...|. ..... .|.  ...||||.. .. ....   |.. .
kkfIatQgPl....kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkq

YHFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKF
.|.. |||||||..|  .|.....|....       .| ||..||||||.||||||...|..|.|. ...    .|.  .....|.|| |.||...||.|
lhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYif

VYYAVQ
.| |..
lykail

0040439 (Phosphotyrosine protein) phosphatases II 543-746 2.1e-62 206.3 In-house 54-246 (249) alignment
Range on Protein: 543-746
Range on HMM: 54-246/249.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHFQ
...|||||.|      || |||.|.|... .|||| |.. |.|.||||.|||. | | ..|. .....|... .|||.|.. ..   |.. |.. |... 
rrfiatqgPlpe....tvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqyt

VWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 ||||||| ..  .|.|.. |.. ...|    .|.||..||||||.|||||||.....|.|. ..    ..|.. .....||||.| ||.. ||.|.|.|
dwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyea

VQHYI
.....
llell

0045098 (Phosphotyrosine protein) phosphatases II 543-747 1.8e-61 203.3 In-house 64-273 (278) alignment
Range on Protein: 543-747
Range on HMM: 64-273/278.0
KTYIATQGCLLtqqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-----RDQPARRIFH
|..|||||.|     .|| |||.|.|.....|||| |...|.|.||||.|||. | |...|. .. ..||  ..||||| .||        | . | ..|
kkfIatqgPlp....stvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvth

YHFQVWPDHGVPADP--GCVLNFLQDVNTRQSHLAQAG-------EKPGPICVHCSAGIGRTGTFIVIDMILDQIvrnglDTEIDIQRTIQMVRSQRSG-
.|.  ||||||| .|    .|..|. .. ....||.         ...||. ||||||.|||||.......|...     .  .|.. .....|||| | 
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpgl

LVQTEAQYKFVYYAVQHYIQ
 ||.. ||.|.|........
avqnleqyrflyefllelll

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 543-757 1.7e-60 199.7 In-house 89-291 (318) alignment
Range on Protein: 543-757
Range on HMM: 89-291/318.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARR-IFHYHFQ
|.|||.|. |     .|..||| |||. |..|||| |.| ||||.|..||||..| |...|. ...  .| ..|||.|||| |. ... . | .  ||. 
kayiaaqaPl....petieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhyt

VWPDHGVPADPGCVLNFLQDVNTrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.|||.... .|.....|..     ||. .. ||| ||||||.||||.||..|..|..|  ..|   .|.  |....|.||  .|||| ||.|.| .
sWpdegvpesgaslldlvrqvsk.....aqqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydv

VQHYIQTLIARKRAEE
.. ....  .   |..
llealasgdtevdasd

subfamily_PTPN9_pd Subfamily PTPN9 543-748 1.8e-58 193.0 In-house 85-292 (297) alignment
Range on Protein: 543-748
Range on HMM: 85-292/297.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTLREFLVS-WRDQPARRIFHYHF
|..||||| |     .||.||| |||.....||||||.  |||. ||..||| .|. |..||. ... |. ....||. | . ..  ...  |.. |. |
kafiatqGpl....kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqf

QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQA------GEKPG-PICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEA
  |||.||| .   .|..|. |  .|. ....      |.  | || |||||||||||||| .|. |... . |    .|.. |....|.||.  .||. 
lsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpe

QYKFVYYAVQHYIQT
||.| | ||  | ..
qyefcylavleyale

subfamily_PTPRA_pd Subfamily PTPRA 543-746 4.7e-58 191.6 In-house 101-295 (330) alignment
Range on Protein: 543-746
Range on HMM: 101-295/330.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVS-----WRDQPARRIFH
...||.|| .     .|| ||| |.|. ..  ||| |.  || .||||.|||||| .  .|. |..   |. . |||.|.|||       |....| .  
dkfiaaqGPk....eetvedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrq

YHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAqagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKF
.||. ||| |||..|  .|..|. |.. .   |      ||| ||||||.||||||||.| .|...     .  .|. .... .| ||. .|||. ||.|
fhftswPdvGvPfepiGmlkllkkvkklnqqsa......gpivvhcsaGvGrtGtfivldavlervka...erkvdvfefvkrlrlqrpqmvqtdeqyef

VYYAVQHYI
.| ....| 
iykvlleyy

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 543-748 5.2e-58 191.6 In-house 91-285 (319) alignment
Range on Protein: 543-748
Range on HMM: 91-285/319.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA--RRIFHYHF
. .||||. |     ||. ||| |||.|.. ..|| ||  |..| |. .|||.|   |..|.  ..  .|. ..||  |.. .  . .    |...|...
ekfiatqaPl....entiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqy

QVWPDHGVPADPGCVLNFLQDVNTrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. ||||.|| .   .|..|....      .. ... ||| ||||||.||||||||.|..|... ..|.   .|.  |....| ||  .||...||||.|.
teWpdhdvPekatslldllkrirk.....srektqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiye

AVQHYIQT
|. .....
alleavea

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 543-749 8e-58 191.0 In-house 89-286 (305) alignment
Range on Protein: 543-749
Range on HMM: 89-286/305.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYH
|.||..|| |     |||.|||.....| ...||| ||  | ||.|| .|||.. .  ..||.  ..  ||...|||. |.. .|    |.  | . .|.
kkyivaqgPl....kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyq

FQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.  |||||||  .. .|.....|. .|..     .|  |. ||||||.||||.||..|. |... . .   ..|. . .. .||.| ..||| .|| |..
ltdWPdhGvpqfatsllslikrvqkdqkk.....dkgvpllVhCsagvgRtGvfiavdialerlkkEe...vvdvfevlkqlRskrmkmvqtldqYvflh

YAVQHYIQTL
 |.. .|.. 
daldelitcg

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 543-748 4.5e-55 181.7 In-house 84-278 (281) alignment
Range on Protein: 543-748
Range on HMM: 84-278/281.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQV
| |||||| .     .....||.|||... ..||| |.| | || || |||||.  . ..|. ... ..|.... |  |.| .. .. ..|.. . ... 
keyiatqgPv....PaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlayta

WPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
||||||||..  .|.| ..|.  ...  .      |...|||||.|||||.| .| ..... ..   .|.|.. ... .| .|  .||| .||.||| ||
WPdhGvPattkellefrkevlkltekktk.....aplvihCsaGvGrtGtyialDrlvkaveae..leeldvkavvaelrkernlmvqtvvqyefvykav

QHYIQT
 .... 
ldaldk

subfamily_PTPRG_pd Subfamily PTPRG 543-751 3.1e-52 172.5 In-house 91-292 (563) alignment
Range on Protein: 543-751
Range on HMM: 91-292/563.0
KTYIATQGCLLtqqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-----RD--QPARRI
| .||||| |     .|. ||| |.|..|. .||| |.  |||..|| .|||    ||..|. ... ..|. .. || |.. .        .  .  ...
kafiatqgplk....dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv

FHYHFQVWPDHGVPADPGCVLNFLQDVntrqshLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQY
 .||.  |||||||  .  ||.| .         |   .. ||| ||||||.|||||.||.| .| || ..     ... ......|.||  ||||| ||
rqyhytkWPdhgvPehslpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqY

KFVYYAVQHYIQTLIA
 |.. |..  |..   
iflhdalleaiasket

subfamily_PTPN14_pd Subfamily PTPN14 543-747 5.2e-51 168.4 In-house 93-297 (300) alignment
Range on Protein: 543-747
Range on HMM: 93-297/300.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEG---RSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHY
..||..|| |     .||.|||.|||......||| |.| | ||||. .|.|...   .. .||. ...    .... .. . . . .   .  | ..| 
rsyivaqgPl....eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAG---EKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQY
 .. ||||||| |.   |..|..|.  . .  .     |.  |. ||||||.||||  |. |...  .  |    ||||.......| ||  |||| |||
qytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqY

KFVYYAVQHYIQ
|||| .. .|..
kfvYkvlikylk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 543-751 1e-50 167.3 In-house 64-269 (270) alignment
Range on Protein: 543-751
Range on HMM: 64-269/270.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS---EQFGHARIQCVSENSTSDYTLREFLVSwRDQPARRIFHYH
|.|||..| | |    |...|| |.|.|... |||||.  |.|..||.|||| |  .    ..|. ..  .||. .. | |..  .  ..   ||. |..
kkYiaamgPlpt....tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfw

FQVWPDHGVPADPG------CVLNFLQDVNTRQSHLAQAGekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEA
.. ||||||| ...       .|. |..|   ...|..|.    |. ||||||.|||||.|..|...  . ..   ...|. . |. .| .|  |||.  
yntWpdhgvpreedsslstdqllkmlravrrsekeldkae....PllvHcsaGvgRtGtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpe

QYKFVYYAVQHYIQTLIA
||.|.| ||..|.... .
qyeflykavveyaerrak

subfamily_PTPRK_pd Subfamily PTPRK 543-742 4.2e-50 165.4 In-house 86-273 (314) alignment
Range on Protein: 543-742
Range on HMM: 86-273/314.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSeqFGHARIQCVSENSTSDYTLREFLVSW--RDQPA-RRIFHYH
. .|.||| |     .||.||| .|..||.  ||| |.  | |. || .|||....   .|. ....|. .  ...  | | |.   | | . | . ...
aafivtqgPl....qetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfq

FQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqageKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVY
|  ||||.||     .|.... |.. | .      . |.| |||||| |||||||.||..|| | |.|.   .|.  ... .||... .|.|| ||||.|
flgWpdhdvPvsatgllklvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiy

YAV
 ..
dvi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 543-750 4.3e-50 165.4 In-house 87-284 (315) alignment
Range on Protein: 543-750
Range on HMM: 87-284/315.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFlVSWRDQPARRIFHYHFQ
|.|||.|| | .    .| |||.||.||..  ||| ||  |  | ||..|||| .. | .||  ... .| ....| . |.. |  . .  |..  ..|.
kayiasqgPlka....svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqft

VWPDHGVPADPGCVLNFLQDVNTRqsHlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.||. . . .|.....| .   .    |.|  .. ||||||.|||| .| || ...|| |.     .|. ......|..|  ||||| .| |.| |
ewPdkGvdkqtssllklikevkad..n....gkkefsllvhcsaGvGrtGvvisidevvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiyda

VQHYIQ---TLI
|. ...   |||
vledllwrntli

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 543-750 6.7e-50 164.6 In-house 86-283 (515) alignment
Range on Protein: 543-750
Range on HMM: 86-283/515.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFHYHFQ
|.|||.|| . .    .| |||..|.|||.  |.| ||  |  | ||..||||  | | .||. ... || .. .. . |.. |   |. .| .  .||.
kayiasqgPnka....svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhft

VWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.||| .  ..| ....| . .....       |. .|||||.|||| .| || .. ..        .|. .... .| .|  ||||. || |.| |
eWPdkGvpkhtssllklikevkadhgqyth......pliihcsaGvGrtGvvisidsvvahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiyga

VQHYIQ---TLI
|. ..    |||
vledllwrntli

subfamily_PTPRN_pd Subfamily PTPRN 543-749 1e-47 157.3 In-house 100-295 (297) alignment
Range on Protein: 543-749
Range on HMM: 100-295/297.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENS-TSDYTLREFL-VSWRDQPARRIFHYHF
 .|||||| |     .||.|||.|||.. . |||. |.  | | ..|.||||||| || ..   .. |||   . || .| |     . . .| .  .||
payiatqgpl....astvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhf

QVWPDHGVPADPGCVLNFLQDVNTrqSHlaqAGeKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnGLdTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||..|||| .  .|.| . ||   |.    | .  || ||||.| ||||..|.||..|..... |.  ||||  |.. .| ||.|||.|..|..|.. 
lswpeegvPasaksllefrrkvnk..sy...rG.rscpivvhcsdGaGrtGvyilidlvlnrllk.Gv.keidiaatlehlrdqrpglvktkdqfefalt

AVQHYIQTL
|| . ....
avaeevnai

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 543-749 2.6e-46 152.8 In-house 91-286 (290) alignment
Range on Protein: 543-749
Range on HMM: 91-286/290.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQ--PARRIFHYHF
| |||||| .     ||. |||...|||.. .||| |.. | ||.||  ||||.  ....|. .|. ..|.....|. |.. |  ...  ... . .|..
kqyiatqgpv....sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqi

QVWPDHGVPADPGCVLNFLQDVNTRQSHlaqAGekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. |...|  ..|  .|  .. ..  | .    |   ..| ||||...||...|..... ...   .|    ||.   ..  |.|. |.|||. ||.....
tnwdstgkvtnpqtillvieemyktqrk...rg..ntsivvHCSdtvgrsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifq

AVQHYIQTL
 | .|....
ivltyldsf

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 543-741 9.5e-46 150.9 In-house 45-234 (237) alignment
Range on Protein: 543-741
Range on HMM: 45-234/237.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWR--DQPARRIFHYHF
|.|||.|| | .    .  |||.|||||.  |||| |   |. ..|| .|||.  . . .|   .    ..  ||||.| .|.| |   .  | |. |.|
kkyiaaqgples....scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqf

QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAgekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
 .|||.|||     .| | ...  |  |....    ||  .|||||.|||| |.||| .| |   .     .||   .. .  .|  ..||. || |.. 
tswpdrgvpqqtaallrfrkniinrsphvses....gpwiihcsagvgrtgiflvidamlrqakek...kvvdiynyvysieedrpyiiqtkdqyvfihq

A
.
t

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 543-742 4.6e-44 145.6 In-house 92-275 (315) alignment
Range on Protein: 543-742
Range on HMM: 92-275/315.0
KTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFHYHFQV
. |||.||     .|..| ||| .|..|.   ||| |.  |. |.|. .||||.     .|.  .  .||.  ..|| | . |  .|.  | .. .|.  
rryiaaqgp....nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdn.irevvqlhyts

WPDHGVPADPGCVLNFLQDVNtrQSHLAQAgekpGPICVHCSAGIGRTGTFIVIDMILDQIvrnGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
||| |||.    ..|. . |.  | | ...    |.| ||||||.||||||| .| .|||.     .  ||. . |. ||..| ..||. .||.|.| |.
wpdmgvpkytiplmnlirtvk..qhhtnsv....gaivvhcsaGvGrtGtfitldavldqa...eaenaidvynfitgvrqnrikmvqvaeqyqfiydal





subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 543-746 3.1e-43 143.1 In-house 91-288 (325) alignment
Range on Protein: 543-746
Range on HMM: 91-288/325.0
KTYIATQGCLltqqVNTVTDFWNMV--WQenTRVIVMtTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQP-ARRIFHY
....|.|  |     .|. |.| .|  |.  . |.|. . | . ||..|| |||.| | | .||  ... .. .  |||  | . |   ..  .| .  .
dvflaaqaPl....tatindlWrlvldWr..csvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqf

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
..| |.| ||.  | .....|| |.. .  .    .  .|| ||||||.||||.|| .  .|....    ....||   .. .| .|  .|.|  || ..
qlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdqyili

YYAVQHYI
| |.  ..
yealveay

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 543-748 6.2e-43 141.8 In-house 86-280 (287) alignment
Range on Protein: 543-748
Range on HMM: 86-280/287.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRsEQFGHARIQCVSENSTSDYTLREFLVSWR--DQPARRIFHYHF
| .|.... .    .||. .||......|  .||| ..| |  .|.| .|||.|     .|. .|. ..|. ...|. |.. |  .  ... ...  |..
kafiiaesPm....fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqi

QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  |...|  ..|  .|  ... .  | . ..     ..| ||||...||...|. ... ...  ..|    ||. . ..  | |. | ||| .||||.. 
tnWdstgkvtepqtillvieemyktqrkrgn.....tsivvhCsdtvGrsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtveqykfind

AVQHYIQT
.|..|...
ivleylds

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 543-747 4.9e-37 122.2 In-house 85-294 (301) alignment
Range on Protein: 543-747
Range on HMM: 85-294/301.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA---------
| .||.|| .     .|..|||...||| .  ||| |.. |. |.|| .|||. | .||.||.  .. |.|.   |...|.. |  .|            
kkfiaaqgpm....kktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfk

-------RRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQR
       . .  ..   ||..||  .|  ||. ..||  ||          ||. ||||....|.|... ... |.|  ..|    .|.   .. || ..
vksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigg.....gpvvVHCSdtVsrsGvYcsvsiglEQckaegV...Vdvfqvtkavrrsk

SGLVQTEAQYKFVYYAVQHYIQ
 | |.|  || ..| ... |.|
pgaVtTLeqytsiydvidmylq

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 543-746 1.4e-34 114.3 In-house 91-279 (439) alignment
Range on Protein: 543-746
Range on HMM: 91-279/439.0
KTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKekcarYWPDEGRSeQFGHARIQCVSENSTSDYTLREFLVS-WRDQ--PARRIFHYH
| ||||||     . .|. ||| .|....|  ||| |.  |  |     ||| ..    .|   ...  .    .|..| | |   ||.    | ....|
klyiatqgp....kkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfh

FQVWPDHGVPADPGCVLNFLQDVNTrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVrngLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.  |||. |||.   ||.||. .|.     |.  |. ||. ||||||.||||| | .|. |.|.    |. ..||.  ....| ||  .||. .|| |.|
yiawpdknvpaqashvldflrains.....andkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiy

YAVQHYI
 ||   |
navledi

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 543-747 1.1e-31 105.1 In-house 82-278 (307) alignment
Range on Protein: 543-747
Range on HMM: 82-278/307.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSEN------STSDY--TLREFLVSWRdQPAR
| .|..|| |     ||. .|| |. ||.   ..|  |  | .| || .|||  ||.   ||.|      .|      .  .    . .. | |  | .|
kkficaqgpl....entqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksr

RIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRnGLDTeIDIQRTIQMVRSQRSGLVQTEA
 | |. .. |||.|||    . .|.|. |.  .           |. ||||||.||.|| . | .. |.... | .   |... .. .||||   .||||
tiqhlqwenwpdrgvpqinltainlleavrydtn..........pvvvhcsaGvGrsGtivaislvqdkmia.Ginc.kdmkklveelrsqrhyaiqtea

QYKFVYYAVQHYIQ
|| ...  . .|  
qylylhrvlleyfl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 543-744 3.1e-28 93.3 In-house 88-234 (392) alignment
Range on Protein: 543-744
Range on HMM: 88-234/392.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGkekcarywpdegrseqfghariqcvsenstsdytlreflvswRDQPARRIFHYHFQV
|.|||.||      . .. |||.||.|||.  |.| ||  |                                            . . || .  .||  
kayiasqgpn....aaslddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhfte

WPDHGVPADPGCVLNFLQDVNtrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
|||..||    ..|.|...|.      |. |.   |. .|||||.||||  | || .. .  .      .|.   .  .| .|  .|||. || |.| ||
wPdkdvpkhtssllkfikevk......adfGqythpliihcsagvgrtgvvisidsvvahakkt...rmvdvfnfvtnirrkrpymvqtkeqyafiygav

QH
  
le

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 543-746 1.1e-27 91.5 In-house 96-289 (305) alignment
Range on Protein: 543-746
Range on HMM: 96-289/305.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFgHARIQCVSENST--------SDYTLREFLVSWRDQPARR
| .|..|| |     .|. .|| || |..   |||  |  | || |||.|||   . |.  . .  .| || .        ..  .  . ...  .    
krficaqgpl....dqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa.qgekl.elksgivvenvsgskpmerdaeiqitllnltysgdqkms

IFHYHFQVWPDHGVPAdpgCVLNFLQDVNtrqshlAQAGEKpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTeiDIQRTIQMVRSQRSGLVQTEAQ
. | ..  ||| |||    | |  |. .       |  | |  || |||||||||||| . |. ||..|  |       .   .. .| ||.  .|.. |
vrhlqwtewpdrgvpp...ckltslells......airgsk.vpivvhcsagigrtgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvq

YKFVYYAVQHYI
| |..  .  |.
ylfihrvmlnyf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 543-746 6.2e-27 89.3 In-house 75-270 (285) alignment
Range on Protein: 543-746
Range on HMM: 75-270/285.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCV--SENSTSDYTLREF-LVSWRDQPARRIFHY
 |||.||| |     .|..||| |..||.   ..|    .| | |||| |.|.. |   .||.  |      |.. .   |  . ..   |  .  ..  
styittqgpl....petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymn

HFQV--WPDHGVPADPGCVLNFLQDVNtrqshlaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQrsgLVQTEAQYK
| ||  |||.  | |   .... . |.       .   |  |||||||||.||| ||. ||    .|. |     .|| | .. .| |    ||.  |. 
hvqvpwwpdqlapedarpmielykwvk.......kvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfq...avqshmqfl

FVYYAVQHYI
|.|  .  |.
flyvvlmeyf

subfamily_ptpA1_pd Subfamily ptpA1 543-700 1.7e-26 87.9 In-house 89-253 (418) alignment
Range on Protein: 543-700
Range on HMM: 89-253/418.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFG----------HARIQC--VSENSTSDYTLREFLVSWRdQ
| .|.||| |     ||..||| |||..  |.||| ..| |  . || ||||..   |||              ..   | ..   .   |.  ...   
kqfictqgpl....pntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.g

PARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMIL
 .| | .|... |||| .|     . ..|. .  || ..  . ..  || ||||||.||||||    ...
etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 543-742 8.6e-26 85.2 In-house 81-265 (281) alignment
Range on Protein: 543-742
Range on HMM: 81-265/281.0
KTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGhaRIQCVSENSTSDYTLREF--LVSWrDQPARRIFHYH
. || |||     . .| .||| |.|||||  |||  .  |  .|||| |.| . .   ||   ..    |.|| . .|      .|. .  .| | |. 
rgyiltqgp....kketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfd..klsvsyedstvnkslvttrlnlsy.egetrlithwl

FQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNglDTEIDIQRTIQMVR-SQRSGLVQTEAQYKFV
.. |||  ||     .|. |. . .| .          |  .|||||.||.||.. ... |. |      |  ||.. .  .| . |.  |||  || ..
wkewpdwqvpessevmlkilrkirarst..........ppvihcsagvgrsgtlmaveialqsihsh..ftlpdikqivshlrvtgraasvqtlqqymli

YYAV
.  .
wkvl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 543-752 3.3e-25 83.6 In-house 72-265 (267) alignment
Range on Protein: 543-752
Range on HMM: 72-265/267.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEyerGKEKCARYWPDE-GRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQ
...|.||. |     ||.|||.... ...  |||. ||    ....  ..|| . |.....    ..   |.   || .  . . .... |. .  |...
nafivtqdpl....kntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyyk

VWPdhgVPADPGCVLNFLQDVNTRQsHLaQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |    . ..    |. |  . ... .| . |..  |. |.||.|.||.|||.|||  |... ..|     ||   .. .|||| |||.|  .| ...  
kwn...intnnkpylkplfgilakn.ql.engnr..PlvvacsdGvGrsGtflvidsqlerakteg...vsdifdflrkirsqriglvdtkeryiyihel

VQHYIQTLIAR
. .| .  . .
laeyaegrlke

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 543-743 1.4e-24 81.2 In-house 94-287 (310) alignment
Range on Protein: 543-743
Range on HMM: 94-287/310.0
KTYIATQGCLltQqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTsDYTLREFL-------VSWRDQPAR--
.|.| .|| |  |   |. ||| |..|| .  |..  |  | |. ||  |||  | .| .|  |.  .|| |  .. . ..        |   .|||   
stficsqgpl..q..htiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlk

--RIFHYHFQVWPDHGVPADpGCvlnflQDVntRQSHLAQAgeKPGPICVHCSAGIGRTGTFIVIDMILDQIvRNGLdtEIDIQRTIQMVRSQRSGLVQT
  |.   ..  ||| ||| .  |     . |   |  |||   . ||  ||||||..|... . ... .|.. ..||  ..|..  .  .. .|   .||
elrvslikwpnwpdrgvpde.kc.....htv..pqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkl.drgl..kvdaeevktellksraiciqt

EAQYKFVYYAVQ
| || .. .   
elqyliidrvri

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 543-739 1e-19 65.5 In-house 5-197 (199) alignment
Range on Protein: 543-739
Range on HMM: 5-197/199.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD---QPARRIFHY
. |||||  |     .|..|||.|||.  .  |||   .    .   . |||  |  . ..|   . . .  . .|||.  ....        .| | ||
rryiatqhpl....retmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HFQVWPDHGVPADpGCVLNFLqdVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQiVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 |  | ..  |      . |.  | .|.       ||  |. |||| | | || |. .|. .     .   . .|.    . .|  | |.. .  .|.|.
qftswkekttpnv.alfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfi

Y
|
y

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 543-739 1e-19 65.5 In-house 4-196 (198) alignment
Range on Protein: 543-739
Range on HMM: 4-196/198.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD---QPARRIFHY
. |||||  |     .|..|||.|||.  .  |||   .    .   . |||  |  . ..|   . . .  . .|||.  ....        .| | ||
rryiatqhpl....retladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HFQVWPDHGVPADpGCVLNFLqdVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQiVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 |  | ..  |      . |.  | .|.       ||  |. |||| | | || |. .|. .     .   . .|.    . .|  | |.. .  .|.|.
qftswkekttpnv.alfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfi

Y
|
y

subfamily_CG42327_pd Subfamily CG42327 543-672 1.5e-19 64.8 In-house 72-202 (319) alignment
Range on Protein: 543-672
Range on HMM: 72-202/319.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR---SEQFGHARIQCVSENSTSDYTLREFLVSWRD-QPARRIFHY
  |||.|  |     .. .||| .||. ..||||  |. .| | ..||.|.| .      . .|. ..     ..   | .  .|.   | . .| . ||
nsyiaaqvsl....edsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthy

HFqVWPDHGVPADPGCVLNFLQDVNTR--QSHLAQA
 .  |.. .|||..  ..  | .|..      | ||
wy.kwleaevPaeeaaliamllevrsslksysleqa

subfamily_eak_pd Subfamily eak 543-761 7.5e-19 62.3 In-house 93-320 (332) alignment
Range on Protein: 543-761
Range on HMM: 93-320/332.0
KTYIATqGcllTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSE-QFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFHYHFQ
. || | |     . . |  ||.|| ....  ||.  .. | . ||  .|.||..| | .||.  ... .    . .  | . .|  .. . |..||.. 
rkyilt.G...iasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGne.thrvlhykvf

VWPDHGVPA--DPGCVLNFLQDV----------NTRQSHLAQAGEKPG---PIcVHCSAGIGRTGTFIVIDMILdQIVRNGLDTEIDIQRTIQMVRSQRS
 | .  .|   |   . . ...|          .  .| | .    |    || . .. |  |.|.|.|||... ... |       ..  |  |.|.| 
GwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskri

GLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQ
  | .. |. |.| .| .|...   | |  .. |.
hsvlvalqhsfiyeivldyllrrnnrlrdlkkyle

subfamily_PTPN13_pd Subfamily PTPN13 544-748 8.8e-53 174.3 In-house 78-271 (273) alignment
Range on Protein: 544-748
Range on HMM: 78-271/273.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHA--RIQCVSENSTSDYTLREFLVSWR-DQPARRIFHYHF
.|||.|| |     .||.||| |||. ...||.| |.| |.|| || ||||.. ...   .   ... .  .  .....|.. |.    . .|.. | .|
eyiacqGPl....PetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf

QVWPDHGVPADPGCVLNFLQDVNtrqsHLAQageKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  |||||||. .  .|.|.. |.    .|..   . ||| |||||||||.||.|.||..|. | |.    |.|.. ... .| || |.|||. || ||| 
vkwPdhgvPssaaellqfvaevr....rlqt...dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvyk

AVQHYIQT
|. . ...
ailevlks

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 544-742 1.1e-49 164.4 In-house 105-287 (319) alignment
Range on Protein: 544-742
Range on HMM: 105-287/319.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTkeyergKEKCARYWPDEGRsEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYHFQ
 |||.|| |     ||. ||| |.|. |.  ||. |      |.||..||| ..  .. ..  ..  | . |..|..|.. .|   . .  |.|  .||.
kyiaaqGPl....dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhfl

VWPDHGVPADPGCVLNFLQdvntRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.|||  |  .. ...    . .|| .  ... .| ||||||.||||..||.|..||.. .   .  .|. .... .| ||. |||  .||||.| |
GwpdvGvpdypsdlmrlvk....kvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysa

V
.
l

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 544-743 5e-49 162.3 In-house 69-252 (284) alignment
Range on Protein: 544-743
Range on HMM: 69-252/284.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTkeyergKEKCARYWPDEGRsEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYHFQ
 |||||| |     ||. ||| |.|. |.  ||. |      |.||..||| ..  .. .. ...  | . ...|..|.. .|   . .  |.|  .||.
kyiatqGPl....dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhfl

VWPDHGVPADPGCVLNFLQdvntRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.|||  |  .. ...    . .|| .  ... .| ||||||.||||..||.|..||.. .   .  .|. .... .| ||. |||  .||||.| |
gwpdvgvpdypsdlmrlvk....kvrhltskenhranivvhcsagvgrtgvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysa

VQ
. 
ll

0036282 (Phosphotyrosine protein) phosphatases II 544-740 2e-41 136.9 In-house 18-164 (174) alignment
Range on Protein: 544-740
Range on HMM: 18-164/174.0
TYIATQGCLLtqqvntvtdFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDegrseqfghariqcvsenstsdytlreflvsWRDQPARRIFHYHFQVW
 .||.||.|          || |..... ...|| ..|.|.|..|| .|||.                                |. . | ...|..  |
rliagqgpla.........fwemlkelgittvvmlleekelglykcinywpe...............................lredlerlgiqylylpw

PDHGVPADPGcVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVrnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
|||||| ..  .|.|.. |.. .|.      . ||. ||||||.|||||.......| ..      . .|. ......|.||.| |||. ||.|.||
pDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrflyy

0043147 (Phosphotyrosine protein) phosphatases II 544-744 2.3e-37 123.7 In-house 21-159 (172) alignment
Range on Protein: 544-744
Range on HMM: 21-159/172.0
TYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEyergkekcarywpdegrseqfghariqcvsenstsdytlreflVSWRDQPARRIFHYHFQVW
 .|||||.      ||. |||.|..... ..||. |..                                           . ....  | ...|..  |
rfiatqgp....lrntladfwrmlkelgithivnltel...........................................lydpellerlgiqylylpw

PDHGVPaDPGCVLNFLQDVNTRQshlaqAGEKPGPICVHCSAGIGRTGTFIVIDMILdqivrngldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQ
|||||| ..  .|.||. .....     | .. ||..||||||.|||||.......|           .... ....||..|.| ||.. ||.|.||  .
pDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsqyrflyyfek

H
.
l

subfamily_CG7180_pd Subfamily CG7180 544-747 6e-36 118.6 In-house 86-291 (296) alignment
Range on Protein: 544-747
Range on HMM: 86-291/296.0
TYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVSWR-----------DQPA
 || |..     . .|| .||..|..|..  .|. ||. .  | ..  ||| ..  ||.|.  .. |.|.. .. . |.| .  .           . . 
eyivteap....kketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaet

RRIFHYHFQVWPD-HGVPADPGCVLNFLQDVNTRQSHLaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQT
| . ......|.  . ||     ...... |.. . .  .  .. ||..|..| | .|.| .. ||. |... .   . |.|. . ....| .| .||..
RivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeegPvvvvssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLven

EAQYKFVYYAVQHYIQ
  .||..|  ..... 
veeYkyiYdvlleavl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 544-748 8e-36 118.3 In-house 81-279 (287) alignment
Range on Protein: 544-748
Range on HMM: 81-279/287.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSE-NSTSDYTLREFLVSWRDQPA-RRIFHYHFQ
..||.|| .      || ||| .|..... .... |.| | .. || .|||.  .  . |   .  ..  .   .|. | . .   .    | .  ... 
afiaaqgPi....aatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldll

VWPDHGVPADPGCVLNFLQDVNTrQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||....     .. |  ||.  .  ||. ... ||. ||...||||.|... . .....    |   ..|. ...  .| .| .|||.  |....| |
swPdkvlaPtavglirfvldvkq.hielardasevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyea

VQHYIQT
.  | .|
lvtyykt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 544-741 6.4e-35 115.2 In-house 95-278 (290) alignment
Range on Protein: 544-741
Range on HMM: 95-278/290.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLV-SWRDQ-PARRIFHYHF
..| ||| |     .|| |.| || ||.. .|||  .  | || ||..|.|. ||.   ||.  . |  |..  . . .  |    .|.    .. |.. 
mfiltqGal....kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlki

QVWPDHGVPADPGCVLNFLQDVNTrqshlaqageKPGPICVHCSAGIGRTGTFIVIDMILdQIVRNGldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. |||. |.     .|  |. . .           .||. |||||||||||||. |.. | ||. .|   |.|.  ... .|  | . || . ||  .  
kswpdksvalstlallrtlrilrk..........asGpvvvhcsaGiGrtGtfvaievgl.qilldG..keldlldlvralrnsrlnsvqvdiqylalve

A
.
i

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 544-743 3.5e-33 109.7 In-house 77-292 (297) alignment
Range on Protein: 544-743
Range on HMM: 77-292/297.0
TYIATQGCLltQqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTSdY---TLREFLVSWRdQPARRIFHYH
 || .|| |  .  .|| |||..|.... ||||| .|  | |..||| |||.      . |.  .. .|. |   .    | |. . .| .  | . |  
kyilaqGpl..s..atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyr.sesrvvrhvq

FQVWPDHGVPADPGCVLNF--------------LQDVN-------TRQSHLAQAGEKPGPICVHCSAGIGRTGTFIViDMILDQIVRNGLDTeiDIQRTI
|  |||||||.|   .  |              |  |.        .   |  .  .. .. ||||||.||.|  .   ... ...|..     |..  .
flswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvl.sdvilaklrkkrip..dvaail

QMVRSQRSGLVQTEAQYKFVYYAVQ
...|.||. ||||  |....| || 
silreqrarlvqtleqfellydavl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 544-747 1.3e-30 101.2 In-house 89-288 (305) alignment
Range on Protein: 544-747
Range on HMM: 89-288/305.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSE-QFGH--ARIQ--C-------VSENSTSDYTLREFLVSWRDQP
 .| ||  |     .| .||| | .|..   | |  .  |.| .||. |.. . . . .|     .|.  .         ... .. |  ....    . 
rfictqapl....ektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgek

ARRIFHYHFQVWPDHGVPADPGCVLNFLQdvNTRQSHlaqagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRnGLDTEiDIQRTIQMVRSQRSGLVQT
||.. |||.  ||| ||||   ..|..|.  ..| |.        ||| |||||||||||. .... ||||..  |   | | .. .| .| ||   .||
arkvthyhwidwpdrgvpaadlailelle..karpsk........gpivvhcsagigrtgsvvmleyildqlla.gqiie.dtdkilqkireqrnnsiqt

EAQYKFVYYAVQHYIQ
.||| ||.  .  |..
daqylfvhqvilnyfr

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 544-738 1.1e-23 78.5 In-house 91-273 (301) alignment
Range on Protein: 544-738
Range on HMM: 91-273/301.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTS--DYTLREFLV--SWRDQPARRIFHY
 .||||| |     ||  ||| |. | .   ||| ... |. .|||. | | . ..  . |  .|. .....    . . |.. |  | .. ..| . ||
rfiatqgPl....kntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthy

HFQVWPDHGVPADPGCVLNFLQdvntrqshLAQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 .. |.|.|||     . ....        |..  ||  || |||||||||. .||  ...  ..     | .|....... .| .|   |||. |  ..
qysewtdrgvPkshaelfdlme........lvkksek..PivvhcsaGiGrsvafigteylarevea...dptieltealkhlrehrwngvqtnsqlywm





subfamily_PTPN23_pd Subfamily PTPN23 545-749 3.5e-48 158.9 In-house 85-283 (288) alignment
Range on Protein: 545-749
Range on HMM: 85-283/288.0
YIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA-RRIFHYHFQV
.||||.     . .|. ||| ||... ..|||| ... |.||.|..|||| |.|....||. .. . |...|. .  |.. .. .|. | . . | ... 
fiatqaP....lqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqlts

WPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQI-VRNGLDteiDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
||..|||| |. .|.||. |..  ..  .  ..  |. ||||||.||||.| ..  .. .. ..|||    || . .. .| ||   ||...|.||.| |
WpelGvPasPetllqfldevesayeavqrkskt..PlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyea

VQHYIQTL
| ....  
vleaarrv

0051429 (Phosphotyrosine protein) phosphatases II 545-753 9.6e-46 151.9 In-house 24-232 (272) alignment
Range on Protein: 545-753
Range on HMM: 24-232/272.0
YIATQGCLLTqqvnTVTDFWNMvWQENTRVIVMTTKEYERGKEKCARYWP-----------DEGRSEQFGHARIQCVSENSTSDYTLREFLVSWR---DQ
.....|.|      |. ||| . .... ..||. ..|.|||..|| ||||           |.  .  .|. |. ..||  ..||.|||.|...    ..
lyrsggplpl....taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

PaRRIFHYHFQVWPDHGVPADPgcVLNFLQDVNTrqshlaqagekPGPICVHCSAGIGRTGTFIVIDMILdqiVRNGLDTEID--------IQRTIQMVR
. |...|.|.. ||||||| ..  .|..|. ...           .||. ||||||..||||.......|    . .|.| .|        ........|
a.revmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYlltnlyleeaveelr

SQRSGLVQTEAQYKFVYYAVQHYIQTLIARK
.|| | ||||.||.|.| |..... .|....
aqrpgavqteeqylflyeallellrsllsvr

0046846 (Phosphotyrosine protein) phosphatases II 550-747 1.4e-38 127.7 In-house 26-174 (176) alignment
Range on Protein: 550-747
Range on HMM: 26-174/176.0
GCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDegrSEQFGHariqcvsenstsdytlreflvswrdqparrifHYHFQVWPDHGVP
..     ..|. ||. |..... ...|. |.|.| |. ||..|||.    |..|.                                .|..  |||||||
iatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi................................qylhlpwpDhgvp

ADpGCVLNFLQDVNTRQSHlaqaGekpGPICVHCSAGIGRTGTFIVIDMILDqivrnglDTEIDIQRTIQMVRSQRS-GLVQTEAQYKFVYYAVQHYIQ
 .   .|..|. .......    |   ||. ||||||||||||.......         .  .... ....||.||. | |||..||.|.|........
dl.elllellefirealke....g...gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqtpeQyrflyefellllk

0044763 (Phosphotyrosine protein) phosphatases II 551-745 7e-32 105.9 In-house 30-170 (178) alignment
Range on Protein: 551-745
Range on HMM: 30-170/178.0
CLLTQQVNtvTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRseqfghariqcvsenstsdytlreflvswrdqparriFHYHFQVWPDHGVPA
 .|... .   |......... ..||. |.|.|.|..|| .|||.|                                       ..|..  .|||||| 
lylgslpp..addlellkelgithivnlteelelgflkcdpywpeeag.....................................iqylhipipDhgvpd

DPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSgLVQTEAQYKFVYYAVQHY
 .  .|.|.. ... .       ||.||. ||||||.||.||........ .         ....  |..||..|.  |... |....|.  ...
llehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 551-771 2.3e-18 61.0 In-house 86-301 (312) alignment
Range on Protein: 551-771
Range on HMM: 86-301/312.0
CLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQ---C----VSENSTSDYTLREFLVSWR--DQpARRIFHYHFQ
|  .   ||.| ||...    .  |.. .   | | ||||.|  |     ..   |.    |    .  .|    | | . |  .   |   .. || . 
ctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwa

VWPDHGVPADPGCVLNFLQDVNTrqshlaqaGEKpgPICVHCSAGIGRTGTFIVIDMILDQIvRNGldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||||.|      | .|  |.           |  |.  |||||.|||||...|. ..  . |       ... .  ..| .|.  |.. .|| ..  .
swpdhgmpdscdtalrllsavkk........dkk..pviahcsagvgrtgtlaliesmiaal.rhp..rkqnvkdsfvllrkdrarsvrvfpqyvyalrc

VQHYIQTLIARKRAEEQSLQVGREYTNIKY
| ... .    || |..  ..   |..|| 
vleflyskglykrneqewtkfketyakika

0051082 (Phosphotyrosine protein) phosphatases II 552-741 1.3e-31 104.6 In-house 16-148 (151) alignment
Range on Protein: 552-741
Range on HMM: 16-148/151.0
LLTQQVntVTDFWNMVWQENTRVIVMTTKEYERGkeKCARYWPDEGrseqfghariqcvsenstsdytlreflvswrdqpaRRIFHYHFQVWPDHGVPAD
.....     ||........ ..||. ..|.|||  .|..|.|..|                                   ....|...  |||.|.|  
yrsggp..ladflellkelgiktivnlrseeerg..ycpeylpelg...................................ievlhipildwpdpglpls

PGCVLNFLQDVNTrqshlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
.  ||.||. ..           |.||. ||||||.|||||.......| .         .... .....|..| |.||.. |. |...|
fdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 552-753 2.7e-24 80.6 In-house 39-225 (255) alignment
Range on Protein: 552-753
Range on HMM: 39-225/255.0
LltqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFgHARIQCVSENSTSDYTLREFLVS--WR-DQPARRIFHYHFQVWPDHGV
|      ||  |.... | .| |.|| .  .| |.||| .|.| |    .   | .. .. .|..|  ||   .       . .. . ||... |...  
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PADPGCVLNFLQDVntRQSHlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNG---LDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHY
| ..  .|| |. |  |.|.         .. ||||.||||. .|......  ...|.      .|.|  . .. .||.|.. ..|  |  |  . |  .
Pelareilnilkvv..rdsk.........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

IqtlIARK
.     ..
v...fpkg

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 554-746 1.6e-10 35.1 In-house 88-279 (303) alignment
Range on Protein: 554-746
Range on HMM: 88-279/303.0
TQQ--VNTVTDFWNMVWQENTRVI--VMTTKEYERgkEKCARYWPDEGRSEQFGHARIQcVSEN----STSDYTLREFLVSWRDQPArRIFHYHFQVWPD
||     | .|||.|. ... ...  ..|  ||..        .| .    .| .  |. | |      .  ..|.   ||  |  .  .  .|.. || 
tqlplshtaadfwqmiieqkvkcvlllltdseydk..lggdsvfprnqdflkfeersir.vgefkrvelgdgwvlkvlsvsngdyks.flhvhhykawph

HGVPADPGCvlNFLQDVNTRQSHLAQAGEKPGPICVHCsAGIGRTGTFIVIDMIldQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHY
  .|.|     .|....   || | .  .   .. .   .| ||.||| ...    ..     .. .|. . ...||  |   ||  .|. .||  .  .
nsipsdgsp..kfvkqiwqlqsvlrkysdstptvymsl.sgcgragtfalfeta..hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

I
.
v

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 555-759 1.6e-24 81.5 In-house 75-272 (290) alignment
Range on Protein: 555-759
Range on HMM: 75-272/290.0
QQVNTVTDFWNMVWQENTRVIVMTTKEYERGKE----KCARYWPDE-GRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVP
..  |. .|| |. ||. . .||. .  |. ..     ||.| |.. | . .|.   ..| |     |   || .| . |.    . |. .. | .  |.
krnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvq

ADPGCVLNFLQDVNTRQShlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRngLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL
 |.  .|. .| |.....          |. |||  || |  ..  |..    |.   .  .. ..  ....|.||  ..... .. || ...  ...  
edtktllsliqkvkaskt..........pvivHcvdGiSrsAalaaiilgyQkiae..tsgsvkledvlkalrkqralaitsalelafvdagivllaiev

IARKRAEEQS
  .   ||. 
ldqfaeeete

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 555-758 2.2e-15 50.9 In-house 101-297 (302) alignment
Range on Protein: 555-758
Range on HMM: 101-297/302.0
QQVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTlREFLVS-WRDQPARRIFH--YHFQVWPDHGVPA
.... | .|| ||.||.   .|.  .| |  |     ..|   |  ...|. ..     ..... .  .. .    .  .  ..   |... |... || 
dsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpv

DPGCVLNFLQDVntrqshLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLI
  . . .  ..|       |.  .   .. .    |.|| |.|..  . .... ..    |  |. ... .||||.  |..  || ..| |.  ||.. .
kyaeliktaakv......fakkikadentvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkv

ARKRAEEQ
 .   ...
tkpeekkk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 556-747 6e-45 148.6 In-house 101-285 (297) alignment
Range on Protein: 556-747
Range on HMM: 101-285/297.0
QVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWPDEGRSEqFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIF-HYHFQVWPDHGVPA--DP
. .|| ||| ||..|.. .||| ... || | ||||||.|.| .. ||.  ..  | .. . .  ||. |.  .  |||.   |.|  |||. |.   . 
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

GCVLNFLQDVntRQSHLAQAgEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQ
  .|.....|  |...  .| |   |. |||.||.|||| .. || .. .. |.    |.||  .....| .|  ||||. |||||| ||  .. 
ssllklisev..rkdfsqna.eg..PllvhclaGvGrtgvlltidsvvaeakre...kevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_hpo-7_pd Subfamily hpo-7 556-761 5.3e-21 69.7 In-house 43-242 (263) alignment
Range on Protein: 556-761
Range on HMM: 43-242/263.0
QVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQfGHARIQCVSENSTSDYTLRE--FLVSWR-DQPARRIFHYHFQVWPDHGVPADP
 |.|.  |.... | .| |.|| .  .| |.||| .|.| |    |   | .. .. .. ||  |.   .|      .  . . || .. |...  | ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq.klanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

GCVLNFLQdVNTrQSHlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNGL---DTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL
  .|| |. |.. .|.         .. ||||.||||.  | |....  ...|.      .|.|  . .. .||.|.. ..|  |  |  . |  ..   
reilnilk.var.nsk.........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn

IARKRAEEQSLQ
 |.  .| .  .
fakgeleakyqe

0049260 (Phosphotyrosine protein) phosphatases II 557-740 5.9e-37 122.1 In-house 19-144 (152) alignment
Range on Protein: 557-740
Range on HMM: 19-144/152.0
VNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWpdegrseqfghariqcvsenstsdytlreflvswrdqparrifHYHFQVWPDHGVPADPGCVL
 ||. |||.|... . ..||| |...|.||.||..|.                                           .|..  ||||||| .. ..|
pntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDhgvpdlsqlll

NFLQDVNTRqshlaqAGEKPGPICVHCSAGIGRTGTFIVIDMILdqivrngldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
 .|. .. .      | .| ||. ||||||.|||||.......|           .... ....||..|.| |... |..|.|.
flllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 557-755 4.1e-09 29.5 In-house 128-314 (346) alignment
Range on Protein: 557-755
Range on HMM: 128-314/346.0
VNTVTDFWNMVWQENTRVIVMTTKEyERGKEKCARYWPDEGRSEQF-GHARIQ----CVSENsTSDYTLREFLVSWRDQPARRIfHyHFQVWPDHGVPAD
   | ||| |..||. ... .   . .. |.  .  . ||    |. |.  |.     || .   .||.  .     |    .. | |   |     |  
esfvedfwymiyqeqihlvylmvpd.dklkntttslfndenggyqytgkmfinnrradvsgd.pkeytievlpegnsdsvicqv.h.hhapwkhlqqppk

PGCVLNFLQDVNTRQsHLAQAGekpgpICVHCSAGIGRTGTFIVIDMILDQIvRNGLDTeiDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIqtliA
   ..... .  . .  . .||     .||    | ||. .||     ..|.  ||..   .|   .. .. || | |.. |||  .|  |  ||    |
tlpiikmihqflsek.qvqnag.....vcvvslfgcgracsfigalyainql.nngiep..niceimknikqqrpggvesfaqyasiyaivfdyi....a

RKRA
||| 
rkrg

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 558-747 7.2e-24 79.3 In-house 93-272 (288) alignment
Range on Protein: 558-747
Range on HMM: 93-272/288.0
NTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARR--IFHYHFQVWPDHGVPADPGC
 |.  .|.|. ... . ||| ..  |.|||| | |.|   |.. ..|.   .   ...  | ...  |.    .   .  . . |.. |.|.||| .   
gtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenyls

VLNFLQDVntrqshlaQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVrngLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQ
 |..|. .        .. .|  || ||.|||.|||||.|.| ..|...    ||  . |.. ..  | .|   .||| || .|.  | ... 
plrllevl........kslqk..PivvhssaGvGrtgtlililialeslr...lddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 558-742 1.3e-17 58.2 In-house 102-284 (302) alignment
Range on Protein: 558-742
Range on HMM: 102-284/302.0
NTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENS-TSD---------YTLREFLVSWRDQPARRIFHYHFQVWPDH
.|.  .| .. | |. ..|  ..  | ...||| |. |. .   .||.  .. || .   ..         ||.      ....  . .   .|  ||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPADPGCVLNFLQDVNTRQSHlaqagekpgpICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
| |...   |. |.  .. .            . ||||||.|||||.. |   ..  ...      |.   .. ||. | | ||.| |  ..   |
Gapkeaytaldilkfcesykkn..........vlvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqdeqqliylllcv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 581-736 3.7e-07 23.9 In-house 142-292 (332) alignment
Range on Protein: 581-736
Range on HMM: 142-292/332.0
EYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFhYHFQVWPDHGvpADPGCVLNFLQDVNTRQSHL-AQAGEKPGPI
| |   . | ..||...  ..|    ||.  . | .     .. |. . |  . ..  ||  | |      |  .|..   .. .  .   ..|   |||
ecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvl.mhfyewadas..klpeymldmrasiklqyirsskktgvcigpi

CVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYK
 . |..|. .   .  ||.|. .|     .  . .. |.  .. || | ..|   | 
mlvcatgvekcaisatidiivsrite...ehrvgfketmsaikmqrfgcfrtvgpys

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 615-745 3.4e-22 73.4 In-house 74-193 (440) alignment
Range on Protein: 615-745
Range on HMM: 74-193/440.0
TSDYTLREFLVSWRdqpARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaQAGEkpGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDI
 |||    .. .     .| . .||.| |||.|||   | ||...||||  |    .||.  ||. |||||| ||||  |..| || .  |.    .|||
dsdyinasyingie...srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqe...kagn..gpllvhcsagagrtgviiavdsilreakrs...dqidi

QRTIQMVRSQRSGLVQTEAQYKFVYYAVQHY
   |. .|..|  .|||  || ||. || . 
fsfinsmrnnrpqmvqtpeqyafvheavleg

0048179 (Phosphotyrosine protein) phosphatases II 621-740 3.7e-25 83.7 In-house 47-139 (144) alignment
Range on Protein: 621-740
Range on HMM: 47-139/144.0
REflvswrdqparrIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaqageKPGPICVHCSAGIGRTGTFIVIDMILdqivrnglDTEIDIQRTIQM
||            ...|..  ||||||| ..  .|.||. ... ..       ..||. ||||||.|||||........           .... ....
re............giqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealal

VRSQRSGLVQTEAQYKFVYY
|||.|.| |... |..|...
vrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 625-745 3.5e-26 87.0 In-house 37-142 (145) alignment
Range on Protein: 625-745
Range on HMM: 37-142/145.0
VSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagekPGPICVHCSAGIGRTGTFIVIDMILDqivrngldTEIDIQRTIQMVRSQ
 | .. . | ...|..  ||||||| ..  .|.||. ... ...       .||. ||||||.|||||.......|           .... ....||||
tselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsq

RSGLVQTEAQYKFVYYAVQHY
|.| |... |..|.|......
rpgavpnpgqlrflyefelel

subfamily_PTPDC1_pd Subfamily PTPDC1 632-744 9.5e-10 33.2 In-house 80-174 (182) alignment
Range on Protein: 632-744
Range on HMM: 80-174/182.0
ARRIFHYHFQvWPDHGVPAdpgcVLNFLQDVNTRQSHLaqageKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSGLVQT
.. |..| |  |.|.||..    . . |. |   .. |     . | . ||| || ||||  |   ..  .        ... ...|..|||.|.  .||
eqgiyvynfg.wkDygvas....leriLdivkvvafal.....qegkvavhChaGlGrtGvliacylvyak........rltaekaiklvrskrpksiqt

EAQYKFVYYAVQH
  | ..|    ..
reqvelvkefalf

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 635-746 9.5e-19 62.3 In-house 217-344 (350) alignment
Range on Protein: 635-746
Range on HMM: 217-344/350.0
IFHYHFQVWPDHGVPADPGCVLNFLQ----DVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILD--QIVR------NGLD----TEIDIQRTI
... ... |.| ..  .|  .|. |.     ...  ...    ..  || ||||||.|||||.. .|..|   .|..      . ||    |.  |. ..
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

QMVRSQRSGLVQTEAQYKFVYYAVQHYI
. .|.||  .||.  |. |.| |...| 
nelrkqrismvqnldqfifiYeallfyf

0038934 (Phosphotyrosine protein) phosphatases II 636-748 9.8e-13 43.7 In-house 80-179 (194) alignment
Range on Protein: 636-748
Range on HMM: 80-179/194.0
FHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILdqivRNGLdteiDIQRTIQMVRSQRSGLVQTEAQY
..|.   .||.|.. .   .|.||. |..  .       ..| . ||| ||.|||||...  .|     |.|.    . .  |...|. | | ...  ..
ieylklpfpddgtvPsleillrfldlvdeflne.....dpggvvaVHCkaGlgRtGtlvaaYLiy....rlgm....saeeAialfrekRpgaipnqdyl

KFVYYAVQHYIQT
. ..  ...... 
eallkrykelrka

PTPc_DSPc_SM00012 637-743 1.6e-33 110.4 In-house 4-104 (105) alignment
Range on Protein: 637-743
Range on HMM: 4-104/105.0
HYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldTEIDIQRTIQMVRSQRSGLVQTEAQYK
|||.  ||||||| ..  .|..|..|.. ... ..     .|..||||||.||||||...|..|.|. ..   .|.||.......|.||.|.||||.|| 
hyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqyl

FVYYAVQ
|.| |..
flyrall

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 638-746 5.9e-11 36.3 In-house 223-344 (349) alignment
Range on Protein: 638-746
Range on HMM: 223-344/349.0
YHFQVWPDHGVPADPGCVLNFLQD----VNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILD--QIVRN---GLDT----EIDIQRTIQMVRSQ
  .. |.| ..  .|  .|. |.     ...  ..|    ..  .. |||||| ||||... .|..|.  . ..|    ..     .  |. ..  .| |
lqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkq

RSGLVQTEAQYKFVYYAVQHYI
|  .||  ||. ..| |. .|.
rismvqnlaqfiaiyealLkyf

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 638-747 3.9e-07 23.9 In-house 232-339 (347) alignment
Range on Protein: 638-747
Range on HMM: 232-339/347.0
YHFQVWPDHGVPADPGCVLNFLQDVNTRQS-HLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnGLDteIDIQRTIQMVRSQRSGLVQTEAQYK
|    || .  | |   || ...      |  |    ||  |. | |  |. |. | ..  .|..|..  |     | .  .. .| ||.|.      | 
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvld.gkt..pdcddlfkkmrdqragvftmsifyt

FVYYAVQHYIQ
.   |   |..
yairaalfylk

0048567 (Phosphotyrosine protein) phosphatases II 638-699 9.3e-07 23.4 In-house 40-100 (157) alignment
Range on Protein: 638-699
Range on HMM: 40-100/157.0
YHFQVWPDHGvPADPGCVLNFLQDVNTRQShlaQAGEKPGPICVHCSAGI---GRTGTFIVIDMI
...  . |.| | . ... .| . .|   .   .  .....|.|||.||    |||.|.|   .|
vyedfffdfG.PlnlailyrFilklnkflk...ilelagkaiavhckaglkkrgrtatLigcYli

PTEN_1 643-740 1.7e-06 23.0 In-house 102-187 (196) alignment
Range on Protein: 643-740
Range on HMM: 102-187/196.0
WPDHGVPAdpgcvLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMIldqivRNGLdteIDIQRTIQMVRSQR-SGLVQTEAQYKFVYY
..|||.|      |..|.|.  .  . ... .. . . ||| ||.||.|| .   ..     . |     . . ....||..|  | ...  | ....|
ieDhgaps.....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLm.....ykgk...ltadeAlelvrekRppgapnspsqerlley

DSPc Dual specificity phosphatase, catalytic domain 659-699 6.4e-06 21.1 Pfam-A 56-96 (133) alignment
Range on Protein: 659-699
Range on HMM: 56-96/133.0
LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMI
 .. .   . ...| .| . . ||| ||| |..|.|.  ..
skeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm

DSPc Dual specificity phosphatase, catalytic domain 659-699 6.4e-06 21.1 In-house 56-96 (133) alignment
Range on Protein: 659-699
Range on HMM: 56-96/133.0
LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMI
 .. .   . ...| .| . . ||| ||| |..|.|.  ..
skeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm

PTPc_motif_SM00404 659-725 8.4e-06 20.7 In-house 63-121 (140) alignment
Range on Protein: 659-725
Range on HMM: 63-121/140.0
LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQR
... .   . . .| .| | . ||| ||. |..|.|.  ..  .        .....  ...|...|
skyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr........qlslaeayefvkerR

subfamily_CG42327_pd Subfamily CG42327 662-748 4.6e-16 53.4 In-house 233-317 (319) alignment
Range on Protein: 662-748
Range on HMM: 233-317/319.0
VNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQT
.|   |  .   |. ||. |||| |.||||. |  |. . ..  .     .|| .... || .|.  |.|  ||.|.|  .. | . 
ingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk

subfamily_PTEN_pd Subfamily PTEN 666-744 2.2e-06 22.8 In-house 106-178 (184) alignment
Range on Protein: 666-744
Range on HMM: 106-178/184.0
QSHLAQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteiDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQH
...|..  ..   . ||| || ||||. ||  ..  .....      .. .  . .|.. .  |.  .| ..|.|  . 
ekwleedkkn..vvvvHCkaGkGRtGvlivayllkslllekae....ealelfaeaRtknkkgvtiPsqrRYveYyekl

subfamily_DSP23_pd Subfamily DSP23 669-740 6.7e-06 20.8 In-house 77-140 (148) alignment
Range on Protein: 669-740
Range on HMM: 77-140/148.0
LAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. .| ||   . |||  | |||||..   ..  .        ..    .|  || .| | |.|  | | |. 
veeaeekneavsvhcllgrgrtgtmlacylvker........klaaaeaiaevrrlrpgsvetveqeklvrd

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 680-742 2.4e-09 31.5 In-house 2-61 (69) alignment
Range on Protein: 680-742
Range on HMM: 2-61/69.0
CVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
 ||||.| ||||||| | . . .|  . |   .||   .| .|  |  .|  | .| |.. |.
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 681-742 2.1e-09 31.6 In-house 2-60 (69) alignment
Range on Protein: 681-742
Range on HMM: 2-60/69.0
VHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
||||.| ||||||| | . . .|  . |   .||   .| .|  |  .|  | .| |.. |.
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdal