Gene l(1)G0232 in Drosophila melanogaster

Synonym: CG3101, CG3102, CG32697, Dmel\CG32697, L(1)G0232, MEG2, PTP-Meg2, dMeg2, lG0232, Dmel_CG32697, l(1)G0232

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN9
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP046_AA protein Get Run
DmelP046_AA_515-807 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CRAL_TRIO CRAL/TRIO domain 167-314 4.3e-30 93.0 Pfam-A 3-159 (159) alignment 
Range on Protein: 167-314
Range on HMM: 3-159/159.0
LQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSET--QRAGLVFIYDMSGSKYSNFD---YDLSQKILTLLKGGYPARLKK
...|...... | . |  . .. ..|. | ..|. . .. ....|...|.. |.  |..|.....||.| ..|...   ..| .|||..|.  || ||.|
ileggkvgihgrDkngrpvlylrlgrfdpkklseeelvrllllvlerllklleedgqiegvtvviDmkglslskmlwkpisllkkilkilqdnyperlgk

VLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVP----QLALHVPRKALPIHLGGT
.||| || .||. ||... |. ||.||... ||      .|  ..... ||  ||||
ilivnaPklfkvafklvkpfldektreKikfvspsntpatlekyidpeqlpkelGGt
CRAL_TRIO_2 Divergent CRAL/TRIO domain 177-319 2.8e-14 42.0 Pfam-A 8-148 (149) alignment 
Range on Protein: 177-319
Range on HMM: 8-148/149.0
ARTSSGAAIALFTANRHSPLSvSHTTTLQGIVYQLDSALQDSEtqragLVFIYDMSG-SKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPF
 . ..|  . .| |.. ...  ..  .|. ..  |   .....      | .|...| |. ..... .  |.. .|   |. .||||..| .  ..|  .
gkdregrpvvvfiakylpstd.dydkllkyllhtledeivgkp.....yvlVyfhtglssenkpslswlkklyktlprrykknlkkvylvhpstflksil

-KILRLFVREKL-RER-VFTVSVPQLALHVPRKALPIHLGGTLEVDH
  .|.|||..|  .   ..  |. .|. .. .. |...|.|... |.
stllslfvskkflkkkviyisslseLseyiditqlkkslpgvysyde
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 511-808 9.1e-62 203.9 In-house 5-287 (297) alignment 
Range on Protein: 511-808
Range on HMM: 5-287/297.0
QEGDPKPIDQIVQMVkQRGRHGLI-KEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQknAYISTQGPL
.|  | |. ..  .| |..||  . .|      .|   .   |. . |. |.||...| || ||| ||  . |  |||.|| || |.|.   .|.|| | 
kerrpiplsdfatlv.qknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

PKTSQDFWRMIWEQHCLVIVMTTRVMERGRvKCGQYWepTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPS--SA
. | .|||.|.....  .||| .   || . || .||  ..... .|||  | . ||.  | ..  .||... |.   | |  .||..|||  |.   ||
katvadfWamvldeqvstivmlnddnerdk.kcaryW..sdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

MAMLNFLQKVREKQAQlvqglgdtwagHPRGpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
 ..|.... ||..  |           .  | |..|||.||.|||| ..|.| .... ..  . || |.|.|.| .| | .|  .|| | . |..|. .|
ssllklisevrkdfsq...........naeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

R
 
e
0045450 (Phosphotyrosine protein) phosphatases II 514-805 4.9e-96 317.3 In-house 10-304 (307) alignment 
Range on Protein: 514-805
Range on HMM: 10-304/307.0
DPKPIDQIVQMVKQRGRHGLIKEYADIRNRAP--EGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGD-EPSDYINANFV--------DGYKQKNAY
|.......|.. .. ...|| ||. ....  .   |.. .|.. .| .||||.|.|.|||.||.| ..||. |.||||||..|        |||..|...
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

ISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELRNI-KTDEIRNVSHWQFTSWPDY
| ||||||.|  |||||.|||.. |||| |. .|.||.|| ||| |.|...|..|...|...|.|  ..| |  ||. .  .|.| | | |...|.|||.
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw.Pdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPSSAMAMLNFLQKVREKQAQlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGT---ADIRGTVEKIRSQRAYSIQMPDQYVFCH
|||.|   .|.|...||. ...           .|.| |..||||||.|||||||........||. ||    |.. .|...|.||  ..| |.||.|..
gvppsfeelldfieevrkalee...........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

LALIEYA
 ||.|. 
eallell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 514-804 2e-66 219.1 In-house 4-278 (315) alignment 
Range on Protein: 514-804
Range on HMM: 4-278/315.0
DPKPIDQIVQMVKQR---GRHGLIKEYADIRNRAPeGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLP
.| |.||..  | |.    . |. ..|  |        .  |.   |  |||| ... ||.||| |   . |. |||.||||.|||..|. ||..|||..
qpipldqlityvaqkkastkngfkqdyesipggql.hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

KTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWePTEesSLEFGDYHVRTISVECNEDYMVASLelRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAM
 . .||||...|...  ||| | ..|. . |. .|| | .   . .| . |  .| | |..| | .|    .  |.||.|  ...||||| ||| .....
asvkdfwrlvfeedigkivmltnlvegekrkaekyw.pdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytipl

LNFLQKVREKQAQLVqglgdtwaghprgPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
.|. ..|.  . . |              .||||||||.||||||||||  . ..|     |.   ....|..|   .|. .|| | . ||.| 
mnlirtvkqhhtnsv.............gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
0040438 (Phosphotyrosine protein) phosphatases II 515-809 3.6e-101 333.9 In-house 2-280 (317) alignment 
Range on Protein: 515-809
Range on HMM: 2-280/317.0
PKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEgTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQ
...... .. ..... ..| .|. |...  .. |. .|.. .|  ||||.|.|.||||||.| ...||..||||||..|||...|...| ||||||.|  
vldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPteESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFL
|||||.|||.. |||| |. .|.||.|| |||    ...|..||..|...|.| .... .  ||. . ...| | | |...|.|||.|||.|   .|.||
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

QKVREKQaqlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRG
..|||..              ..| |..||||||.|||||||........||  |. |.  .|...|.||....|.|.||.|.. ||.|| . ..
eavreal.............edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
subfamily_PTPRA_pd Subfamily PTPRA 515-810 8.7e-79 259.8 In-house 13-301 (330) alignment 
Range on Protein: 515-810
Range on HMM: 13-301/330.0
PKPIDQIVQMVKQRGRHGlIKEYADIRNRAPE----GTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLP
| |.... . ...|      | . .  |  |     .|.  |    |  |||. ..| ||.|||.|.. .| | |||||| |.||||.|. .|..|||. 
plpvekleeeirirsadd.nklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

KTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWePtEESSLEFGDYHVRTISVECNEDYMVASLELR----NIKTDEIRNVSHWQFTSWPDYGVPSS
.| .|||||||||.   ||| | . || . || ||| | .| .. .|. .|    ..  .|| |  . ..    . . .. | |. . |||||| |||. 
etvedfwrmiweqksativmltelkerkeekcaqyw.P.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

AMAMLNFLQKVREKQAQlvqglgdtwaghpR-GpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY-
.. ||..|.||.... |               | |||||||||.|||||||.||  . |..  .  |. ..|...| ||.  .|   ||.|.. .| || 
piGmlkllkkvkklnqq.............sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

AYSRGM
 |    
lygdte
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 515-812 1.7e-62 206.1 In-house 2-284 (315) alignment 
Range on Protein: 515-812
Range on HMM: 2-284/315.0
PKPIDQIVQMVKQRGRH-GLIKEYADIRNRAPEGTfLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTS
| |. |.  .|..  .   . .|. |. .  .  .   || . | .|||| ..| .|..||.|   | .  |||||| .. .... .|||..||||. . 
pipvaqfpafvnknrhtalfseefhdlpdPdiyrq.rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

QDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRniKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNF
.|||||.....   ||| |   |  ..|| |||   .  | ||| ..| ..|.| . | ..  | .|  |..| |.|. .||| ||| ||.  . ..|..
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr..kseesrtvtqfqftewPdkGvdkqtssllkl

LQKVREKQAQlvqglgDTWaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQ
...|. .. .      ...       ...||||||.|||| .|..| .......  . |.  .|...|..| | .|  ..| | . |. |. . |  | 
ikevkadngk......kef.......sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntli
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 515-811 3.7e-44 145.7 In-house 3-242 (392) alignment 
Range on Protein: 515-811
Range on HMM: 3-242/392.0
PKPIDQIVQMVKQRGRHG-LIKEYADIRNRAPeGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTS
| |. |.  .|..  .   ...|. |. .         |.   || |||| ..| || .||.|   |    |||.|| .........|||..||| . . 
pipvaqfpafveknrhsalffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

QDFWRMIWEQHCLVIVMTTRVMERGrvkcgqywepteesslefgdyhvrtisvecnedymvaslelrniKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNF
.|||||.....   |.| |.. |                                              | |. | |. ..|| ||| .||  . ..|.|
ddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkf

LQKVREKQAQLVqglgdtwagHprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGML
...|. .  |           |    |...|||||.||||  |..|  ... . .   |.   | .|| .| | .|  .|| | . |..|    |  |
ikevkadfGqyt.........h....pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 516-812 5e-45 148.5 In-house 7-294 (305) alignment 
Range on Protein: 516-812
Range on HMM: 7-294/305.0
KPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLaheDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQD
| | ..|. . ..| .|| .|.. ..       .   .   .  |||| || | |. || |   .|  | .|| ||.|    . . .| || || ||  |
kqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcad

FWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHvRTISVECN--EDYMVASLELRNI---------KTDEIRNVSHWQFTSWPDYGVP
|| | ....   | |   ..|.|  || .|.   ..  ||| .   . ||| ..  . .   .    ..            . | |.|. .  ||| |||
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg.qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvp

SSAMAMLNFLQKVREKQaqlvqGlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDV-GTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
.. .|.|..|.| |  .     |            ||||||||||||||. . |.  . .|       |    . ||| ||  |||  .||.| |  ...
aadlailellekarpsk.....g............pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

YAYSRGMLQ
|   ...|.
yfrkkklld
subfamily_PTPN9_pd Subfamily PTPN9 517-810 6.3e-162 532.6 In-house 2-296 (297) alignment 
Range on Protein: 517-810
Range on HMM: 2-296/297.0
PIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDF
 |...|..||..|..||.||||.|||...|||||....||||.|||||||||||..|||||..|.|| |||||||||||||||.|.|.|||||.||..||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQK
|||.|||..|||||||||.||||.||||||...|||| ||||..|....||..|||.|..||..|.||.|.|.|.|.||.|||||||||||...|..|.|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA-YSRGM
||||||..|. |||.|.|||.||||||||||||||||||||||||.||||.|||.|.. ||...|.|||.|||.|.||.||.||..||| .....
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelkal
subfamily_PTPN14_pd Subfamily PTPN14 517-804 2.6e-65 215.4 In-house 8-295 (300) alignment 
Range on Protein: 517-804
Range on HMM: 8-295/300.0
PIDQIVQMVKQRGRHGL-IKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDePSDYINANFVDGY--KQKNAYISTQGPLPKTS
. |. ....... ..|   .||  | ..  ....  |..  |  |||. ||| |...|| |.    .  ..||||  .      ..  || .||||..| 
tkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltv

QDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPT--EESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAML
||||.|.|||.  .||| |.  | |. |. .|.  .  .....||| ..| |  .|  . ..  .|.|. . . | |.| | |.| ||| |||.    .|
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl

NFLQKVREkqaqLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
..|..|.     . .   ..  .. . ||..||||||.||||  |. |. |. ||   . ||. .....| || . .|   || | . .||.|
syLeevqs....vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
0050432 (Phosphotyrosine protein) phosphatases II 518-807 3.6e-105 346.9 In-house 29-301 (308) alignment 
Range on Protein: 518-807
Range on HMM: 29-301/308.0
IDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLahedgDEPSDYINANFVDGY--KQKNAYISTQGPLPKTSQD
.| . .. |. ....| .|. ....  | ... .|.. .| .||||.|.|.||||||.|     ||.||||||..||||  |.....| ||||||.|  |
ldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved

FWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEE-SSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFL
||||.|||.. |||| |. .|.||.|| ||| .... .|||.|...|...|.| ..||.|  |||.|....| | | |...|.|||.|||.|. ..|.||
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl

QKVREKQaqlvqglgdtwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
..||...               .|.|||||||||.|||||||.||.....||  |. |. ..| |.|.||....| |.||.|.. ||.||...
elvrksl...............pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0039614 (Phosphotyrosine protein) phosphatases II 518-805 1.5e-94 312.0 In-house 19-289 (297) alignment 
Range on Protein: 518-805
Range on HMM: 19-289/297.0
IDQIVQMVKQRGRHGLIKEYADIRNRAPEgtFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDG-DEPSDYINANFVDGYKQ-KNAYISTQGPLPKTSQD
.|..... |. ....|..|. .. .  |.  . .|.  .| .||||.|.|.||||||.| .||| |..||||||..||||.. ....| ||||||.|  |
ldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWRMIWEQHCLVIVMTTRVMERGRvKCGQYWEPTEEsslEFGDYHVRTISVECNEDYMVASLELRNikTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQ
||||.|||.. |||| |. .|.|| || ||| ....   ..||..|....|| ...|.|  ||..|  ..| | | |.|.|.|||.|||.|.  .|.||.
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

KVREKQAQLvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
.||| .|.|           |.| |..||||||.|||||||........||  |. |.  .|...|.|| ...|.|.||.|.. ||.|. 
lvrealael...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPRD_pd Subfamily PTPRD 519-806 3.1e-107 354.6 In-house 11-282 (564) alignment 
Range on Protein: 519-806
Range on HMM: 11-282/564.0
DQIVQMVKQRGRHGLIKEYADIRNRaPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
 . |. .|. .   . .|| .|... .. |. .|.. ||  |||| ... |||||||| . .||| ||||||.|.|||....||| |||||..| .||||
kehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWR

MIWEQHCLVIVMTTRVMERGRVKCGQYWePTEEsSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVR
|.|||.. .||| |.. |.|.||| .|| |... . ..|...|   . |  .||.. ...|.. |..| |.| ...|||||| ||| || ..|....|||
mvweqnsstiVmltkleEkgkvkchkYW.Pekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvr

EKQaQlvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
. . .            |   |||||||||.|||||||..|... |... .| ||...|...|.|| . .| ..||.|.| |. |.  
aln.e............pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0051299 (Phosphotyrosine protein) phosphatases II 519-805 8e-105 345.6 In-house 11-286 (288) alignment 
Range on Protein: 519-805
Range on HMM: 11-286/288.0
DQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
 . |......| .||..|. ....  | .|. .|.. .||.||||.|.|.||||||.| ..||.|.||||||...|||..|...| ||||||.|  ||||
lklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MIWEQHCLVIVMTTRVMERGRVKCGQYWEPteESSLEFGDYHVRTISVECNEDYMVASLELRNI----KTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFL
|.|||.. |||| |...|.||.|| ||| .  ..||..||..|...|.| ..||.|  ||..|.    ...| |.| |...|.|||.|||.|. ..|.||
mvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

QKVREKQAqlvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
..||...|             ..|.|.|||||||.|||||||.||.....||  |. |. ..|...|.|| ...|.|.||.|.. ||.||.
rlvrkala.............sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 519-808 6.5e-91 299.7 In-house 8-283 (318) alignment 
Range on Protein: 519-808
Range on HMM: 8-283/318.0
DQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
.. |. ... |.  | .||  .     . | |..   .| .||||...| |||.|| | . .|.| |||||||..|||..|.|||..|.|||.| .||||
eshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWr

MIWEQHCLVIVMTTRVMERGRVKCGQYWePtEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVR
|.|||.. |||| |...|||..|. .|| | .. | ..|. .|   .    .||.. ...... ...| |.|  ...||||| |||.|.. .|.....|.
mvWeqnsavivmltqeeergkakvhryW.P.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

EKQAQLVQGlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR
. |..  .|            |||||||||.||||.||..|| . |... .. |. .||...|.||   .|  |||.|.. .|.|.  | 
kaqqksgag............pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_PTPRB_pd Subfamily PTPRB 519-805 3.8e-88 290.3 In-house 13-285 (293) alignment 
Range on Protein: 519-805
Range on HMM: 13-285/293.0
DQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
.. |. .|..  ... .|| ....   . .   |.  .| .|||||..| |||||| ||. .... |||||||...||.... .|.||||||.| .||||
eehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MIWEQHCLVIVMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELRNikTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVR
|.||... .||| |...|.|.||| .|| |..|..  .|| .|  .. |  ||... .|....  ..|.|.| ...||||||.|||... ..|.|...||
mvwekkssiivmltqlvekgkvkCeeYW.PadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvr

EKQAQlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
|.. .           . .  |||||||||.|||||||.||  ....|.  . || |.| ..|..|.. .|  .||.| | ..... 
eaiek...........taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 519-811 2.7e-63 208.8 In-house 5-282 (515) alignment 
Range on Protein: 519-811
Range on HMM: 5-282/515.0
DQIVQMVKQRGRHGLI-KEYADIR--NRAPEgtfLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQD
 |.  .|.. ..  |. .|. |.   |  |.     |.   | .|||| ..| || .|| |   . .  |||.|| .. ...  .|||..|||.. . .|
aqfPafvnknrhttlfseefhdlpgpniypq...tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvdd

FWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELrnIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQ
|||......   |.| |.  |  ..|||.||      |..|| ..| ..|.|.  . .   |..  .| |..| |  ..|| ||| |||  . ..| ...
fWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklik

KVREKQAQLvqglgdtwAgHprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGML
.|. .. |.        . |    |...|||||.|||| .|..| .... ..  . |.  .|..|| .| | .|  .|| | . |. |. . |  |
evkadhgqy........t.h....pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntl
0036941 (Phosphotyrosine protein) phosphatases II 520-809 3.2e-101 333.8 In-house 2-281 (297) alignment 
Range on Protein: 520-809
Range on HMM: 2-281/297.0
QIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLahedGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM
... . |. ....| ||. .. .. . |.. .|.  .||.||||.|.|.|||.||.|    .||.||||||..||||..|...| ||||||.|  |||||
llkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

IWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVEC--NEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKV
.|||.. |||| |...|.||.|| ||| ..|..||..||..|...|||   ..|| .  ||. .....| | | |...|.|||.|||.|.  .|.|...|
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

REKQAQLvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRLE---DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRG
|.....|           |.|.|..||||||.||.||||..|.....||     |. ||  .| |.|.||. ..|...||.|.. ||.|. ... 
rkvlkll...........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0043336 (Phosphotyrosine protein) phosphatases II 520-804 1.3e-95 315.3 In-house 9-276 (278) alignment 
Range on Protein: 520-804
Range on HMM: 9-276/278.0
QIVQMVKQRGRHGLIKEYADIRNRAPeGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM
. .. ..  ....|..|. ....  . .|. .|.  .| .||||.|.|.||||||.| ...||..||||||..||||......| ||||||.|  |||||
kallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrm

IWEQHCLVIVMTTRVMERGRVKCGQYWEpteESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVRE
.||... .||| |. .|.||||| |||    ..||..||..|.....| ..||.|  ||. | ...| | | |.....|||.|||.|   .|.||..|||
vwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

KQaqlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
..             .... |..||||||.|||||||.|......||. |. |.  .|...|.||. ..|.|.||.|.. ||.||
al.............edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 520-806 3.9e-87 287.3 In-house 12-284 (319) alignment 
Range on Protein: 520-806
Range on HMM: 12-284/319.0
QIVQMVKQRGRHGLIKEYADIRNRAPEgTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM
. ...... | ..| ||. ....  .. || .| .  | .||||...| ||..||||.. || | ||||||.|.|||......|.||.|| .| .|||||
erlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

IWEQHCLVIVMTTRVMERGRVKCGQYWepTEESSLEFGDYHVRTISVECNEDYMVASLELrNIKTDEI--RNVSHWQFTSWPDYGVPSSAMAMLNFLQKV
.||... ..|| |.. |...||. .||  .||   |.| . |   . |  |||..  |.| |.|..|.  |.|.|.|.|.||| .|| .|...|..|...
vWeeessivvmltklveklkvklkkyw..peenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkri

REKQAQLVQGlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
|. . .  .|            |||||||||.|||||||.||. . |..  |. |.  || ..| ||   .| |.|| |.. ||.|.. 
rksrektqsg............PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 520-804 1.8e-81 268.3 In-house 4-275 (281) alignment 
Range on Protein: 520-804
Range on HMM: 4-275/281.0
QIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM
. ..  .|   .|.|.||.....   . |   ..  .| .||||...  ||..||...... .. .||||||||.|||....|| ||||.|.. ..||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQHCLVIVMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELrNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVRE
.|||.  .||| || .| |..|| .|| | ..|.|..||..|.... | .. |.   ..| . .. | |.|.. ..|.||| |||......|.| ..|..
vweqkvsaivmvtreieagklkChrYW.Pddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

KQAQLVQglgdtwaghprgPPIVVHCSAGIGRTGTFITLDICISRLED-VGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
 . .  .             |.|.|||||.|||||.|.||  ....|.   ..|.. .|...| .| . .|   || | ..|....
ltekktk............aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 520-810 8.1e-78 256.4 In-house 10-284 (288) alignment 
Range on Protein: 520-810
Range on HMM: 10-284/288.0
QIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM
. |.  ..|.| |. .||  . .   . .   .|   | .|||| ..| ||. || | . .  . .|||||...||.|.|..||.|||||..| .|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQHCLVIVMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELRniKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVRE
..|..   ||| | ..|.|. ||..|| |...   ..|.  |  ....  ||... .|.|   |. . ... ..|...||| ||| |.. .|..|..|  
vyenktstivmltelveggktkCeeYW.PdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

KQAQLvqglgdtwaghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGM
 . .                ||.||||||.|||||||.||  | ..|   . |. |||.|.| |||  .|   ||.|.. .|.. .. .|.
anqad.............tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 520-805 4.9e-77 254.1 In-house 16-290 (298) alignment 
Range on Protein: 520-805
Range on HMM: 16-290/298.0
QIVQMVKQRGRHGLIKEYADIRNRAP---EGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDF
..... |. .  |. .|.  ...      | .   || ..|  ||||.|.. .|.||||| .||.|| |||||| |...||..||.| ||.||..| .||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMIWEQHCLVIVMTTRVMERGRVKCGQYWePtEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQK
|||..|..  .||| | . | ...|. .|| | .| . ..|. .|.  | |   |..|  |.. . |... |.| . .|||||| |||. | ..|..|.|
WrmvteedigtiVmltnleeldktkyhkyw.P.degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

VREKQAQlvqgLGDTwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
|| .| |     |..        |..|.||||.||.|||| .|  . |..   . |.. .|. .| .|. ..|  .||||.. | .|. 
vrasqqq....agnk........pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 520-805 4.5e-59 194.8 In-house 9-278 (287) alignment 
Range on Protein: 520-805
Range on HMM: 9-278/287.0
QIVQMVKQRGRHGLIKEYADIRN-RAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAhedgDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
..|.  ...|. |  . .. . .    |    |.    |  |||.|..| .|  ||.|     .|  ||||| |.||||.|.|.| ...|. .| ..||.
efvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWk

MIWEQHCLVIVMTTRVMERGRVKCGQYWePtEESSLEFGDYHVRTISVECNEDYMVASLELRNIK-TDEIRNVSHWQFTSWPDYG-VPSSAMAMLNFLQK
.|....  .||| .. .|  . .| ||| | ||.|. .|.|... .. | |..|..  ||..| . ... ..|  .|.|.|.. | |.. .  .| . ..
liddrnvtaivmlcqekendeevcyqyW.p.eeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

VREKQAQlvqglGDTwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
..... .     |.|        .||||||...||...|.  .. | . .  |. |.   ... | |.  |.|  .|| |   ...|| 
yktqrkr.....gnt........sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 520-807 1.3e-36 121.2 In-house 8-273 (288) alignment 
Range on Protein: 520-807
Range on HMM: 8-273/288.0
QIVQMVKQRGRHGLIKEYADIRNRAPEGTflHARMRANLTKNRYTDVLCYDHSRVVLAhedgDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM
  ...| | .  || ||| |  | |.. .       || |..||... . | .|| |     |.|  ||.|| |   | |.  | .| ||  | . .|.|
awirlvlqiaveglkkeyrdspneasidi..idsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

IWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRN-VSHWQFTSWPDYGVPSSAMAMLNFLQKVr
. |.    ||| ....|.|. |  .|.      .  .| .   .     . | .|    ||. |. | .  | .  .  |.| ||| . .. |..|. . 
llesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.

ekqaqlvQ---GlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
       .                |||||.|||.|||||.|   | .  |  .    ||  ..| | .|  .||   ||.. |  . |.   
.......kslqk............PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 521-807 6.7e-60 197.4 In-house 10-285 (290) alignment 
Range on Protein: 521-807
Range on HMM: 10-285/290.0
IVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLA--HEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
 |.  ...|..|  ...  . . . | |  ..    | ..||..... ||  |..|    .. | . .|||| ...|||.|..|| ||||...|  |||.
fvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MIWEQHCLVIVMTTRVMERGRVKCGQYWEPTeESSLeFGDYHVRTISVECNEDYMVASLELRNIKT-DEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKV
.||.... .||| | ..| |.||| |||  . ...  .| .... .. |  ..|.   ||..| .. .. ..| ..|.|.|.. |      ..|  ....
liwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

REKQAQlvqglgD--TwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
 ..| .      .  |        .||||||...||...|..... | . .  |  |.   ... |.|.  |.|  .|| . .  ...| .|
yktqrk......rgnt........sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 521-805 1.2e-52 173.8 In-house 6-277 (307) alignment 
Range on Protein: 521-805
Range on HMM: 6-277/307.0
IVQMVKQRGRHGLIKEYADIRNRAPEGTFLHArMRANLTKNRYTDVLCYDHSRVVLAHEdGdEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMI
 ||   ..| . |. |.  . ...|||   .| ..||  ||||.|| | |..|.|.  . |   |||| ||..    . . .| .|||| .| ..|| |.
wvqrtldkgvqalvdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvkfd.g.lasdyihanylgiaikpkkficaqgplentqysfwama

WEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYhVRTISVEC-------NEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNF
 ...   ..|  .|.| ...|| |||   |   | ||.   .||||.         .. ..   .|.   ... | ..|.|.. ||| |||   .. .|.
iqekvesvimlckvielakikceqywpleegqklvfgea.pntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl

LQKVREKQAqlvqglgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISR-LEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
|. || ..                  |.|||||||.||.|| ... .   . .. .   |..  ||..|||| |.||   ||.. |  |.|| 
leavrydtn.................pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 521-806 4.3e-36 119.0 In-house 17-291 (310) alignment 
Range on Protein: 521-806
Range on HMM: 17-291/310.0
IVQMVKQRGRHGLIKEYADIRNRAPEgTFLHARMRANLTKNRYTDVLCYDHSRVVLAHeDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMI
..   .. | .||.|.|  .  .    .. .  .. .. ||||.||.| | ||| |   |     ||| ||.|     ....| .|||| .|  ||||||
fiiateklgieglvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmi

WEQHCLVIVMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISvECNEDYMVASLEL----RNIKTDEIR------NVSHWQFTSWPDYGVPSSAMAM
... .  |..  .|.| || ||  || |.   .  .|   |  .| |  |.. .  | .     |.  ||         ||  ..  ||| |||      
fqeraesilllckvgeegrpkcvgyw.pslgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht

LNflQKVrekQAQLvqglgdtwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
.   |..    ||.            |  | |||||||..|... ..|.. | .|.     |.   . ... .||  || . ||.. .   | .| 
vp..qrl...laqv............rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_PTPRG_pd Subfamily PTPRG 522-808 1.5e-76 252.8 In-house 10-290 (563) alignment 
Range on Protein: 522-808
Range on HMM: 10-290/563.0
VQMVKQRGRHGLIKEYADIRNRAPEG--TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPS-DYINANFVDGYKQKNAYISTQGPLPKTSQDFWR
|  ..  | .|. .|. .. ..  .   .  |.. . |  ||||.... ||.||| |.   | . . ||||||..|||....|.| |||||..| .||||
vaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWr

MIWEQHCLVIVMTTRVMERGRVKCGQYWePTeESSLEFGDYHVRTISVECNEDYMVASLELRNIKT------DEIRNVSHWQFTSWPDYGVPSSAMAMLN
|||||.  .||| | . |||| || .|| |. . |...|  .|. |. |    | | .| ..|.|       |. ..| ....|.||| |||....  |.
miWeqnvaiivmitnlvergrrkcdvYW.Pk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLi

FLQKVrekqaqlvqglgdTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR
| .|                | .    |||||||||.|||||.| ||  . ....  . .. |.. .||.|| . .|  .||.| | ||.|   |.
fvkks.............saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_PTPRK_pd Subfamily PTPRK 522-803 8.7e-76 249.7 In-house 13-275 (314) alignment 
Range on Protein: 522-803
Range on HMM: 13-275/314.0
VQMVKQRGRHGLIKEYADIRNRapegtFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIW
....|.   .|. .||  . .      .  |.   | .|||..|.| ||.|||.|   |||  ||||||...|.||. .|.| |||||..| .||||...
iallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EQHCLVIVMTTRVMERGRVKCGQYWePtEESSLeFGDYHVRTISVECNEDYMVASLELRN--IKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVRE
...|  ||| | ..| ||||| .|| | |...  .|| .|  ...| .....|  . ...   . .||| | ..||..|||..|| || ..|.....| .
dencasivmltelvevgrvkClkyW.P.edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk

KQAQlvqglgdtwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
.|..             .  .|||||||| |||||||..|| .  .|  |. |.  .| ..||..   ..  .||.|.. ...|
sqee.............eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 522-805 2.7e-74 245.0 In-house 13-283 (305) alignment 
Range on Protein: 522-805
Range on HMM: 13-283/305.0
VQMVKQRGRHGLIKEYADIRNRaPEGTFLHaRMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIW
.. ..    .|| ..|  . .. .| .... .  || .|||....  .|..|. |.... .. ||||||..|||||.|..|| .||||..| .||||.|.
ikearvysdkgleaqykslyee.eesidvg.kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliv

EQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRN-IKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREK
| .  .||| |...| |. || |||  ..  . |||...|   | .  .||.   |.. .  . .| |.|...|.|.||| ||| .| ..|.....|...
eekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd

QAQlvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
| .             .| |..||||||.||||.||..|| . ||.  .. |. . . ..||.| . .|  |||||.| || |. 
qkk............dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPN6_pd Subfamily PTPN6 523-806 3e-76 251.3 In-house 18-298 (306) alignment 
Range on Protein: 523-806
Range on HMM: 18-298/306.0
QMVKQRGRHGLIKEYADIRNRAPEGTFLH--ARMRANLTKNRYTDVLCYDHSRVVLAhEDGDEPSDYINANFVDGY--KQKNAYISTQGPLPKTSQDFWR
.  .. .. |. .|. ...... . .. .  ..   | .||||  .| .||.||.|. |..   |||||||....   .....||.||| |..| .||||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MIWEQHCLVIVMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELR-NIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKV
|.|.... ||||||. .|||. || .|| |.||.. |.|...|...| . ..||.. .| .  . | .| |.| ...|.|||| |||..  |.|.||..|
mvwqensrvivmttkevErgkekCarYW.PdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

REKQAQLVqglgDTwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGT---ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
..|| .|     ..     .  ||||||||||||||||| .|| .. .|  |.    ||. .|...|.||   .|. .|| | . |. .|  
nrkqeele....ea.....eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0047943 (Phosphotyrosine protein) phosphatases II 524-805 3.2e-100 330.3 In-house 5-272 (273) alignment 
Range on Protein: 524-805
Range on HMM: 5-272/273.0
MVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLahedGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQ
. |. |...|..|. ....  |..|. .|.. .|..||||.|.|.||||||.|    ||..||||||..||||..|...| ||||||.|  |||||.|||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

HCLVIVMTTRVMERGRVKCGQYWEPTEES-SLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQA
.. |||| |...|.||.|| ||| ..... ||..|...|...|.| ..||.|  |||.|..|.| | | |...|.|||.|||.|   .|.|...||....
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QLVQGlgdtwaghprgPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
.|...           .|.|||||||.|||||||.||.....||  |. |.  .| ..|||| ...| |.||.|.. ||.||.
alpsn...........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 525-806 5.5e-75 247.3 In-house 16-287 (307) alignment 
Range on Protein: 525-806
Range on HMM: 16-287/307.0
VKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQH
 |.   .||.|||  . .|  . .   .    |. |||| |.  .|. ||.|..  |.| ||||||.|. |||.|. .|  |.|.  | .||||||.||.
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

CLVIVMTTRVMERGRVKCGQYWePTEeSSLEFGDYHVRTISVECNEDYMVASLELRNIK-----TDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVRE
  .||| . . |  | || .|| | |    ..||  |...| |  .||.  .|.. ..|      .. |.|  ...|.|.|. || .| ..|.....|||
vtlivmlsnlteknrkkcakYW.pie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

KQAQLvqglgdtwaghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
 . .                ||||||||| ||.|.|..||. . .|.   ..||  || ..||||   .|  .||||.. ||..|  
lykln.............rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 525-807 2.4e-55 182.2 In-house 21-285 (290) alignment 
Range on Protein: 525-807
Range on HMM: 21-285/290.0
VKQRGRHGLIKEYADI-RNRAPEGTFLHARMRANL--TKNRYTDVLCYDHSRVVLahEDGDePSDYINANFVDGYKqkNAYISTQGPLPKTSQDFWRMIW
| ... ..| ||| .  .   | . .    . .|   .|||| || | | .||.|  .||  . ||. ||.|.| |    .| |||.| .|  |.|||. 
vvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvil..kdGy.dGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvl

EQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVR-TISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREK
...  .|||   ..| |. || ||.  .|   | ||.. |  . . . ... .   | .|. ..     . |..  ||||  |. |..|.|  |. .|. 
qekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka

QaqlvqGlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
      |            |.||||||||||||||.......  | |    |. ..|  .|  |. |.|.  ||.    .|...  .
s.....G............pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 526-808 1.4e-62 206.7 In-house 18-291 (325) alignment 
Range on Protein: 526-808
Range on HMM: 18-291/325.0
KQRGRHGLIKEYADIRNRAPEgTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHC
| . . |. .|.  . .  .  ..  |   .|  |||. .|. .|.|||||   . |  ||||||...  .|.|. ....| ||..| .|.||.. . .|
kaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

LVIVMTTrVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLV
 |.|..  ... |  .| .||      | .||  .|. ...|   ||.   |.....|  | | |  .|. ||.| ||.    .....|| | . . .. 
svvvvln.eldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

QglgDTWAghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR
    .| |      ||.||||||.||||.||.|   . .. .    || | |.|.| .|   ..  |||.... ||.|.  | 
a...ntka....stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 530-800 2.8e-54 179.0 In-house 6-290 (297) alignment 
Range on Protein: 530-800
Range on HMM: 6-290/297.0
RHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHedGDEPSDYINANFVDGY--KQKNAYISTQGPLPKTSQDFWRMIWEQHCLV
|. | .|.  . . |  ..|  |.  . | ||||.|.| .| .|| |    .   .|||||..|     ...  || .|||| .| .|||....||   |
rkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrv

IVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNF--------------
||| ... | || ||  ||  ...  |. ||. |  .|   .|   |   ||. |  .| | | | || ||||.||||    .  |              
ivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmm

LQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLA
|  |    | ..  |    | .||  ...||||||.||.|  .  |. ...|      |..  ....|.|||  .|  .|. ... |
lalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 531-804 1.6e-42 140.2 In-house 15-292 (301) alignment 
Range on Protein: 531-804
Range on HMM: 15-292/301.0
HGLIKEYADIRNRAPEGTFLHARmRANLTKNRYTDVLCYDHSRVVLAHEDG--DEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVI
... ..| ....  .. . .. .  .| . ||. ..  ||. |..|...        .||||...|||..|...| .|||. || .||||.||...   |
nkfeeqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLE-----------------LRNIKtdEIRNVSHWQFTSWPDYGVPSSAMAML
|| |   |. . || |||. .|..| |||  .|  ..     |... .|                   .. |  . ..|  .| |.||. ||      .|
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvL

NFLQKVREKQAQLvqglGdtwaghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
. ...|  .| .     |        | |.|||||....|.|......| .      |  |. . .. .| ..   ..  .||.. . .. .|
qviddvihrqqki....g........ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
0046845 (Phosphotyrosine protein) phosphatases II 532-807 1.9e-100 331.1 In-house 1-276 (284) alignment 
Range on Protein: 532-807
Range on HMM: 1-276/284.0
GLIKEYADIRNRAPEG--TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGD-EPSDYINANFVDGY-----KQKNAYISTQGPLPKTSQDFWRMIWEQ
||..|.  ...  .    .. .|.. .||.||||.|.|.||||||.| ..||| | ||||||..||||     ..|...| ||||||.|  |||||.|||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

HCLVIVMTTRVMERGRVKCGQYWEPTeESSLEFGDYHVRTISVECNEDYMVASLELRNIK-TDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQA
.. |||| |. .|.||.|| ||| .. ...|..||..|...|.| ..||.|  |||.|.. |.| | | |...|||||.|||.|.  .|.||..||| . 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

QlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVG---TADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
.           .|.|.|||||||||.|||||||.||.....||  |   . |. ..| ..|.|| ...|...||.|.. ||.||...
n...........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPN3_pd Subfamily PTPN3 533-801 2.6e-76 251.2 In-house 17-271 (280) alignment 
Range on Protein: 533-801
Range on HMM: 17-271/280.0
LIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDgdEpsDYINANFVD----GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVI
.....  .  . |. .  .||. .||.|||| |.| ||. || | ...     ||||||.|.    . .. | ||.|||||.||..|||.|.|||.. .|
vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMTTRVMERGRVKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQaqlvqgl
|| | ..||||||| ||| |..| .||.|...|.  . .... |..  | |.. .|.| |.. . |...||| |||...  .|.|...||...       
vmlttlverGrvkChqyW.PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.......

gdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLAL
      . .  |.|||||||||||| .|.|..... .|      .   | ..| |||  .| ..|| |   |.
......sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 533-808 2.7e-71 235.5 In-house 36-295 (319) alignment 
Range on Protein: 533-808
Range on HMM: 36-295/319.0
LIKEYADIRNRAPEGT-FLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMT
|  |.  . .......   .| .  |  |||....| .|...| | . .| | |||||| ||.||..|. ||..||||. | .||||||||..|  ||. 
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TrvmergRVKCGQYWePtEESSLEFGDYHVRTISVECNEDYMVASLELRN-IKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLvQglgd
|      . || ||| |  .   . . ..|.  |||  ..|.| ..|| .  |  .||..  . |  |||.||| ... .. ...|||  . .  .    
t......kdkcsqyw.p.lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.n....

twagHPRgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE-YAYSR
    |..  .||||||||.||||..|.||. ..|...    |.  .|. .| ||   .|   || |.. ||.| . ...
....hra..nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_CG7180_pd Subfamily CG7180 533-804 1.6e-53 176.3 In-house 18-289 (296) alignment 
Range on Protein: 533-804
Range on HMM: 18-289/296.0
LIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTT
. |    . .|   |.  ..    |. |||. .|. ||. |||| . ||.| |||||| .||.. .|..|| |..|  .| ..|||.......  .|. |
eyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

RVMERGRvKCGQYWEPTEesSLEFGDYHVRTISVECNEDYMVASLELRNI----------KTDEIRNVSHWQFTSWPD-YGVPSSAMAMLNFLQKVREKQ
....  . .. .|| ..     ..|.  | .....   .     . |              . | | | . |.| |.    ||.|. |.......||  .
ktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

AQLvqglgdtwAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
 .           .|   |.||..| | .|.| ....|...  .|  .  |. . | ..| .|   ... ..| ..   | |.
ekv........dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 533-813 3.3e-30 99.9 In-house 21-284 (312) alignment 
Range on Protein: 533-813
Range on HMM: 21-284/312.0
LIKEYADIRNRAPEGTFlHARMRANlTKNRYTDVLCYDHSRVVLAhedGDEpSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTT
| |||  . |  ..     | .. .   ||| .. |.|  |  ||   |||   || ||||    . . ...||||| .|.  ||..     .  |.. .
ltkeykavgnivsdsec.taflkfk.dlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

RVMERGRVKCGQYWEPTeESSLEFGDYHVRTISV-----EC--NEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlv
 ..| |  || .|      . ... |. | | ..         ..      | .    | .  .. |.|..||||.|.| |  . | .|  |.  .    
gfvedgsekcakyisdi.vgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk...

qglgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQT
              |.. |||||.|||||.. ..  |. |      ... .   .| .|| |...  |||..  ...|. ||.|. . 
..............pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykr
DSPc_SM00195 534-805 2.3e-92 304.4 In-house 3-262 (263) alignment 
Range on Protein: 534-805
Range on HMM: 3-262/263.0
IKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTR
 .|. .... ... .. .|.  .| .||||...|.|||.|| | .|...|.|||||||...|...|..|| ||||||.| .|||||.||... .|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNE-DYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLvqglgdtw
 .|.|. || .||. ..... .||...| ...||  . .. .  |||.. ...| |.| ..|...||| |||.|.. .|..|..|.... .         
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........

aghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
      .|||||||||.||||||.|.||..|.||.  . ||  .|...|.||. ..|. .|| |.. |..||.
.....sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 534-805 2.3e-92 304.4 In-house 3-262 (263) alignment 
Range on Protein: 534-805
Range on HMM: 3-262/263.0
IKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTR
 .|. .... ... .. .|.  .| .||||...|.|||.|| | .|...|.|||||||...|...|..|| ||||||.| .|||||.||... .|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNE-DYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLvqglgdtw
 .|.|. || .||. ..... .||...| ...||  . .. .  |||.. ...| |.| ..|...||| |||.|.. .|..|..|.... .         
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........

aghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
      .|||||||||.||||||.|.||..|.||.  . ||  .|...|.||. ..|. .|| |.. |..||.
.....sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 534-803 4.3e-69 227.8 In-house 14-267 (273) alignment 
Range on Protein: 534-803
Range on HMM: 14-267/273.0
IKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGdepsdYINANFVDGY--KQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMT
 .|. ..|.  |  |   .. ..| .|||| .|| ||..|| |  | |     ||||...     |..  || .|||||.| .|||.|.|||.. ||.| 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TRVMERGRVKCGQYWEPTEESSLEFGD-YHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQlvQGlgd
|   |.|.||| .||  .....|   . ..|. . |.  ... | .|....... | |.|.| .|..|||.||||||. .|.|...||. | .  .|   
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd..ag...

twaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
         ||||||||||||.||.||.|. .  .|     |.. .|.|.| ||   .|  |||.|.. |..|
.........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRN_pd Subfamily PTPRN 535-803 3e-59 195.2 In-house 33-290 (297) alignment 
Range on Protein: 535-803
Range on HMM: 33-290/297.0
KEYADIRN-RAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFV-DGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTT
||.  . . .| . |   |.   |..|||...|| |||||| | .|  .| |||||| .. |   .. |||.|||||..|  |||.|.||| . |||. |
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

RVMERGRVKCGQYWePtEESSLEFGDYHVRTISVEC-NEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREkqaqlvqglgdT
|. | |  .| .|| | .| |  .. | |. .|     .||.| |. |.|..|.| | |. . | |||. |||.|| ..|.| .||             .
rleeegvkqckryw.p.deGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk...........s

WAGhpRGPPIVVHCSAGIGRTGTFITLDICISRLE-DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
. |  |  |||||||.| ||||..| .|. ..||   |   ||  |.|..| ||.  ..  ||. |.  |..|
yrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0045098 (Phosphotyrosine protein) phosphatases II 536-805 3.7e-85 280.9 In-house 12-272 (278) alignment 
Range on Protein: 536-805
Range on HMM: 12-272/278.0
EYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVlahedgdepsDYINANFVDGYkqKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVM
|.  ..   . .....| .. || ||||.|.|.||||||.          |||||...|||  ....| ||||||.| .|||||.||... |||| |...
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

ERGRVKCGQYWEPteESSLEFGDYHVRTISVECNEDYMVASLELRNI----KTDEIRNVSHWQFTSWPDYGVPSSA--MAMLNFLQKVREKQAQLVQGLG
|.||.|| ||| .  ..||..||..|...|.| ..|| .  |...|.    ...| |.| |.....|||.||||.   . .|..|. .|| ...|.. |.
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

DTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLeDvGTADIRGTVEKIRSQRAY-SIQMPDQYVFCHLALIEYA
 ..  ...| |..||||||.|||||.. .......| . |. |.  .|...|||| . ..|...||.|.. .|.|. 
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN1_pd Subfamily PTPN1 537-804 2.3e-73 241.5 In-house 12-270 (290) alignment 
Range on Protein: 537-804
Range on HMM: 12-270/290.0
YADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGdepsDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVME
| |||. | . .  .|.. .| ..||| ||  |||||..| ..|     |||||..|.  . |  || ||||||.| . ||.|.|||..  .||  .|.|
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

RGRVKCGQYWEPTEE-SSLEFG--DYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQaQLVQGLGdtwa
....|| |||   || ..|..    ..|. || | .. |.|  ||| |.||.| |...|. .|.|||.|||.|  |.|.||.||||    |..  |    
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresG.slssdvG....

ghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGT---ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
      | |.||||||||.|||. .| |. ..|. .     ||. .. ..|..|   || .||  | .||..| 
......pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 537-809 3.2e-70 231.9 In-house 4-260 (284) alignment 
Range on Protein: 537-809
Range on HMM: 4-260/284.0
YADIRNRAPEGT-FLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTrvm
.  . .....||   .| .  |  |||....| .|...| | . .| | |||||| |. ||..|. ||.|||||. | .||||||||..|  ||. |   
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...

ergRVKCGQYWePtEESSLEFGDYHVRTISVECNEDYMVASLELRN-IKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLvQglgdtwag
   . || ||| |  .   . . ..|.  |||  |.|.| ..|| .  |  .||..  . |  |||.||| ... .. ...|||  . .  .        
...kdkcsqyw.p.lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.n........

HPRgpPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE-YAYSRG
|..  .||||||||.||||..|.||. ..|...    |.  .|...| ||   .|   || |.. ||.| . ... 
hra..nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 539-597 2e-08 28.2 In-house 21-78 (244) alignment 
Range on Protein: 539-597
Range on HMM: 21-78/244.0
DIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDgDEPSDYINANFVDGYK
 . ... |     | . || ||||| ..| .|..||.|.     | |||||||...| .
glsdhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq
0049772 (Phosphotyrosine protein) phosphatases II 542-805 5e-49 163.1 In-house 31-280 (314) alignment 
Range on Protein: 542-805
Range on HMM: 31-280/314.0
NRAPEGTFLHARMRANLTKNRYTDVLCYDhSRVVLAHEDGDEpSDYINANFVDGYkqkNAYISTQGPLPKTSQDF----------WRMI--WEQHCLVIV
.  ||.|.| |.  .| .||||.|.|..| .||.|  ....  ||||||..|||.   ...| |||||. |  ||          |||.  ..... .||
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------TTRVMERGrvkcgQYWEPTEESSLEfgdyhvrtisvecnedymvaslELRNIKTDEIRNVSHWQFTSWPDYGVPSSAM
|                      ......|      .. . .   |.                      |  . . .  |.. ..  . .||...|....
msrdevladelsrLdaAlgKtpllildgng.....neptaadlellk......................eelydpelferlgikylripvpDgsaplled

aMLNFLQKVREKqAqlvqglgdtwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLedvGTaDIRGTVEKIRSQRA-----YSIQMPDQYVFCHLALIE
 .. ||. ..|                 .| |..|||.||.||||||.........|   |  ... ..| .|..|       .|....||.|.. || |
.fdeflefieea.d..............kggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealle

YA
| 
yl
subfamily_egg_pd Subfamily egg 542-802 1.1e-34 114.5 In-house 25-267 (307) alignment 
Range on Protein: 542-802
Range on HMM: 25-267/307.0
NRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERgrVK
. . | .. .|    ||.| |   | | | ||| |  . |    |.| || |.|    | .| .| ||  | .|||||......  ||| |   |    .
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CGQYWEPTEESSLEF--GDYHVRTISVECNEDYMVASLELRNIKT-DEIRNVSHWQFtswpDYGVPSSAMAMLNFLQKVREKQAqlvqglgdtwaghprg
|  ||  .|. || .  | ... .. |. . | .    .|. . . || | . |||     |.   |     |. |.|.|.                   
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlsk................

pPIVVHCSAGIGRTGTFITLDICISRLED--VGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI
 |.||..  |. ...|.....| .  |    .    .. .|  .| .| .|.. . .|.| .  ..
.pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 547-806 3.4e-62 204.8 In-house 28-278 (287) alignment 
Range on Protein: 547-806
Range on HMM: 28-278/287.0
GTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEdGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYW
 ||  |   |.  ||||.||| .|..||.|..| |.  |||||||.| .|....|.|..|||.. | .||||...|..  .... || .| .| || .||
atfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

ePTEESSLEFGDYHVRTISVECNE-DYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlVQglgdtWAGHPRGPPiVVHC
 |  |  .  | | |  .. .  | .| | .| | ...| | | |   .. |||| ... .|.... |  .|...    ..       .   ||. |||.
.PerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie..la.....rdasevGPl.vvhd

SAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
..||||.|..... ...|||||.|  |.  .| ..| .||  .| . |. .   ||. |  
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0040439 (Phosphotyrosine protein) phosphatases II 548-805 7.3e-88 289.6 In-house 2-246 (249) alignment 
Range on Protein: 548-805
Range on HMM: 2-246/249.0
TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWE
.. .|.. .|. ||||.|.|.||||||.| . .| ..||||||...|||..|...| ||||||.|  |||||.||... |||| |. .|.||.|| ||| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

PteESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLvqglgdtwaghPRGPPIVVHCSA
.  ..|||.||..|...||| ..||.|  ||| |....| | | |.|.|.|||.|||.|   .|.|...||. ...|           |.| |..|||||
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...........pkggpvlVHCsa

GIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
|.|||||||........||  .. |.  .|...|||| ...|.|.||.|.. ||.|. 
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 549-804 4.8e-79 260.6 In-house 2-241 (243) alignment 
Range on Protein: 549-804
Range on HMM: 2-241/243.0
FLHARMRANLTKNRYTDVLCYDHSRVVLahedgdEPSDYINANFVDGYKQknaYISTQGPLPKTSQD----FWRMIWEQHCLVIVMTTRVMERGRVKCGQ
| .|.. .||.||||.|.|.||||||.|      |.|||||||.......   .| ||||||.| .|    ||||.||... |||| |. .|.||.|| |
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWEpteeS-SlEFGDYHVRTISVECNEDYMVASLELRNIK-TDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVqglgdTWAGHPRGPPIV
||     .   ..||..|...|.|  .||.|  |.|.|.. .|. |.| |.....|||.|||.|   .|.||..||| . .|.     ..   ..| |..
ywp....gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell.....sllaldsggpvl

VHCSAGIGRTGTFITLDICISRLedvgTADIRGTVEKIRSQRAY-SIQMPDQYVFCHLALIEY
||||||.|||||.|........|    . |.  .|...|.|| . ..| |.||.|.. ||.|.
VHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 550-625 1.6e-11 38.4 In-house 30-110 (347) alignment 
Range on Protein: 550-625
Range on HMM: 30-110/347.0
LHARMRANLTKNRYTDVLCYDHSRVVLAHED-----GDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHC
  .    .|.|||  ||   | .||||. |.      |..  ||||  .   . .. || || |||.| .|||.|.   . 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 550-709 2.5e-08 27.0 In-house 20-160 (169) alignment 
Range on Protein: 550-709
Range on HMM: 20-160/169.0
LHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINAnfvdgykqknayistqgplpktsqdfwRMIWEQHCLVIVMTTRVMERGrvkcgQYWEPT
. | . .| |||| .  |.  | || | .   |  ||||||                           |||||    |||.     ..      ..|   
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpek

EESSLE----FGD-----YHVRTISVECN----EDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMA
|.  |     .|.      .|||  |. |    |  .  |. . . . |   ..| .....||. ||| | . 
edyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 550-709 6.9e-08 25.5 In-house 19-159 (169) alignment 
Range on Protein: 550-709
Range on HMM: 19-159/169.0
LHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINAnfvdgykqknayistqgplpktsqdfwRMIWEQHCLVIVMTTRVMERGrvkcgQYWEPT
. | . .| |||| .  |.  | || | .   |  ||||||                           |||||    |||.     ..      ..|   
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpek

EESSLE----FGD-----YHVRTISVECNEDYM----VASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMA
|.  |     .|.      .|||  |. |   .      || . . . |  ...| .....||. ||| | . 
edyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
0042113 (Phosphotyrosine protein) phosphatases II 551-804 1.5e-85 281.8 In-house 3-242 (245) alignment 
Range on Protein: 551-804
Range on HMM: 3-242/245.0
HARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPte
.|.  .| .||||.|.|.|||.||.| ...||. ||||||..||||.... .| ||||||.| .|||||.||... .||| |. .|.||||| ||| .  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

ESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQlvqglgdtwaghPRGPPIVVHCSAGIG
..||..||..|...|.| ..||.|  ||. |...|| |.| |.....|||.|||..   .|.||. ||. .|.            ... |..||||||.|
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae............dsngpvlVHCsaGvg

RTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
||||||........||  .. ..  .|...||||  ..|.|.||.|.. ||.|.
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 551-805 1.4e-72 239.1 In-house 34-277 (290) alignment 
Range on Protein: 551-805
Range on HMM: 34-277/290.0
HARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTE
...   | .|||| |.| ||.|||.| .....| ||||||||. | ..| .||..||||||| .||||||||..  ..||  |..| |. || .||  . 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

ESSLEFGDYHVRTISVEC-NEDYMVASLELRNIktDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlvqglgdtwaghPRGPPIVVHCSAGI
|..||||...| ... .  ..|... .|....   .| |.|  ...|.||| ||||||  .|.....||| |                  |.|||||||.
eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.............sedaPlvvhCsaGv

GRTGTFITLDICISRLEDVGT---ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
||||| |..|.  . |..  .    |.   | ..| |||  .|  .||.. . |..|. 
GrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 551-806 5.6e-71 233.8 In-house 22-269 (274) alignment 
Range on Protein: 551-806
Range on HMM: 22-269/274.0
HARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEP-SDYINANFVDGYKQ-KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEP
. ..  . |||||...|  ..|||.| .|..... |.|||||.. ||.. ..||..||||||.| .||||||..... ||||.|.. |. . || .|.  
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

TEES--SLEFGDYHVRTISVECNEDYMVASLELRNIKTdeIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTwaghprgppiVVHCS
.|.   | ..|| .... ..  ..|| | .| |.. .    |.| |. .|.|||  .| .| ..|.....|.|.. .  . |. .          |||||
aedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv..........vvhCs

AGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAY
||||||| ||. .|.. .|.. .. |. ..| ..| .|   .|  .|| . | ||..|. 
aGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 552-807 6.3e-73 240.0 In-house 4-244 (250) alignment 
Range on Protein: 552-807
Range on HMM: 4-244/250.0
ARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVkCGQYWePTEE
|.  .|. ||||.|.. .|.||||| .|.||. |||||| |..||....|.| |||||..| .|||||..|..  .||| | . | ... . ||| |.|.
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw.Pvek

sSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGlgdtwaghprgpPIVVHCSAGIGR
 . ..|| .|   | |   ||..  | | . |  . | | . .|..||| |||  | |.|..|.||. .| |  ..            |..|.||||.||
.aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna............PvivqCsaGvgr

TGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
.|.||..|  . ||.   . |..  ....| .|  ...  .||||.. .....  |
sGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN23_pd Subfamily PTPN23 552-805 3.3e-62 204.9 In-house 38-280 (288) alignment 
Range on Protein: 552-805
Range on HMM: 38-280/288.0
ARMRANLTKNRYTDVLCYDHSRVVLAhedgDEPSDYINANFVDGYKQK-NAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTE
|  . . .|||..|.| |||.||.|     ..  ||||| || .       .| ||.||..|..|||.|..||.  |||| .   |.|. |. .||   .
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

ESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQaQLVQGLGDTwaghprgpPIVVHCSAGIG
. . .|||..|   ||.  | ..   |.|.  ..|....||| |.||||..|||.|   .|.||..|...  . ||   .|        |.|||||||.|
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesay.eavqrkskt........PlvvhCsaGvg

RTGTFITLDICISRLE-DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
|||.|  .   .  || . | .||   |...| || ...|  .|. |.  | .|.|
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 552-803 1.5e-53 176.4 In-house 2-238 (239) alignment 
Range on Protein: 552-803
Range on HMM: 2-238/239.0
ARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQ-KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEpte
|. | | .||||.... |||||||| .   |  ||||||...  |    .|||.||| .  .| |||||.|...  |||| | ..|  . || |||    
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

ESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREkqaqlvqglgDTWaghPRGPPIVVHCSAGIG
.|. .. . .|     |   ||.. .. . ..   | | | ...|| ||| |||  | |.| . .|. .          |.    |   | |.|||||.|
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..........dsl...pgarpwvihcsagvg

RTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
|||.|. .|  . . .   | ||   |. || .| . .|  .|||| |||..|
rtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 552-803 2e-53 176.0 In-house 3-239 (239) alignment 
Range on Protein: 552-803
Range on HMM: 3-239/239.0
ARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQ-KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEpte
|. | | .||||.... |||||||| .   |  ||||||...  |    .|||.||| .  .| |||||.|...  |||| | ..|  . || |||    
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

ESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREkqaqlvqglgDTWaghPRGPPIVVHCSAGIG
.|. .. . .|     |   ||.. .. . ..   | | | ...|| ||| |||  | |.| . .|. .          |.    |   | |.|||||.|
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk..........dsl...pgarpwvihcsagvg

RTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
|||.|. .|  . . .   | ||   |. || .| . .|  .|||| |||..|
rtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 552-595 6.6e-08 26.3 In-house 42-85 (440) alignment 
Range on Protein: 552-595
Range on HMM: 42-85/440.0
ARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDG
| .  |  |||| ..|.||||||.| .  |   |||||| ...|
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 553-807 4.4e-50 165.2 In-house 29-268 (283) alignment 
Range on Protein: 553-807
Range on HMM: 29-268/283.0
RMRANLTKNRYTDVLCYDHSRVVLAHEDGdepsDYINANFVD---GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWePt
  . | .|||. ... .|  || |  |      ||||| |.     |||.. || .|.|| .| .|||.|.....   ||| |...|  |.|| ||| | 
sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW.P.

EESSLEFGDYHVRTISVECNEDYMVASLELRNI-KTDEI-RnVSHWQFTSWPDYGVPSSAMAMLNFlQKVREKQAQlvqglgdtwagHPRGpPIVVHCSA
.. | ..|.. |       .. ...  | ||.   . .    ..|.|.  | .||  .   ....|  ||. .| .           ...| |||||||.
krGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkf.nkvislqte...........skkg.PivvhCst

GIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
|||||..||..   .  .      |.  .|. .| ||   .|  ||| . | . .| |  
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 553-812 1.5e-36 120.9 In-house 31-277 (285) alignment 
Range on Protein: 553-812
Range on HMM: 31-277/285.0
RMRANLTKNRYTDVLCYDHSRVVLAHEDgdepSDYINANFVD-GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEE
   ||   |||.|| | . .||||   |     ||| |...    |....||.||||||.|  |||.||....   ..|   ..| |  ||  |.     
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

SSLEFGDYHVRTisVECNEDYMV----ASLELRNIK--TDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREkqaqlVqglgdtwagHPRGPPIVVHC
  ..|| | .     ||.|. .      .| . | .  . |   . | |   |||   |  |  |... . |..     |          |.  ||.|||
evvkfgkyeitl..teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.....v.........npkekpicvhc

SAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQ
|||.||| ||. .| .  |. .    ..   | ..|. |  ..|   |..| .. |.||    |...
sagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvve
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 553-812 4.8e-27 89.4 In-house 43-286 (303) alignment 
Range on Protein: 553-812
Range on HMM: 43-286/303.0
RMRANLTKNRYTDVLCYDHSRVVLAHedgdepSDYINANFVDGYKQKNAyISTQGPLPKTSQDFWRMIWEQH--CLVIVMTTRVMERgrvKCGQYWEPTE
..  |. |||..||.| |||.| |.       | || |....   .|.| | || ||..|. |||.|| ||.  |.....|   ...     |..  | .
qfvknmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydk...lggdsvfprn

ESSLEFGDYHVRTI---SVECNEDYMVASLELRNIKTDEIRNVSHwqFTSWPDYGVPSSAMAmlNFLQKVREKQAQLVQglgdtWAghpRGPPIVVHCSA
.  |.| .  .|      ||  . . .  | . | .   .  | |  . .||   .|| . .  .|.... . |. | .     ..    . | |    .
qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgsp..kfvkqiwqlqsvlrk.....ys...dstptvymsls

GIGRTGTFITLDIC-ISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQ
| ||.|||  .. . .|  ..  . |.   .|..|  | ...|   |. . .  | |.    |. .
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngick
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 553-805 6.4e-20 65.8 In-house 47-285 (302) alignment 
Range on Protein: 553-805
Range on HMM: 47-285/302.0
RMRANLTKNRYTDVLCYDHSRVVLAHedgdEPSDYINANFVDGYKQKNAYISTQGPLPKTS---QDFWRMIWEQHCLVIVMTTRVMERGRvKCGQYWEPT
  ..|| ||. .|| ..|. .| |..    || .|.||  |.  . ..  | .| |  ...   ..||||......  .|.  .  |  .    ...  .
afkknlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

EESSLEFGDYHVRTISVECNEDYM-VASLEL--RNIKTDEIRNVSHwqFTSWPDYGVPSSAMAMLNFLQKVREKQAQlvqglGDTwaghprgpPIVVHCS
 .. .|.|.  | .  ||  |.     ..|.   ..    . || .  .| |..  || .  .. .  .|| .|...     .|         ..|.   
sgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv..ltnWkqkkvpvkyaeliktaakvfakkik.....ade........ntvivSk

AGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
 |.|| |.|.|| . ...|..     |  .|..|||||. ...  .|||. ..||. | 
nGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 554-805 6.7e-41 134.8 In-house 34-269 (281) alignment 
Range on Protein: 554-805
Range on HMM: 34-269/281.0
MRANLTKNRYTDVLCYDHSRVVLAH-EDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEES
   |  ||||... | | ||| |       . .||| ||..     |  || ||||  .|  |||||||..    |||  ...|  | || .|.      
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

SLEFGDYHVRTISVECNEDYMVASLELRniKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlvqglgdtwaghprgpPIVVHCSAGIGRT
 |.|  . |       |.  . . |.|      | | ..|| .  |||. || |.  ||. |.|.| . .                 | |.|||||.||.
clqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrkirarst.................ppvihcsagvgrs

GTFITLDICISRLED-VGTADIRGTVEKIRS-QRAYSIQMPDQYVFCHLALIEYA
||.....|..  .   .   ||.  | ..|   || |.|  .||..    |... 
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 554-641 6.9e-16 52.6 In-house 31-117 (332) alignment 
Range on Protein: 554-641
Range on HMM: 31-117/332.0
MRANLTKNRYTDVLCYDHSRVVLAHEDGDEpsDYINANFVDGYKQKNAYISTQGPLP-KTSQDFWRMIWEQHCLVIVMTTRVMERGRVK
.  |.  ||   . |.||||| || .|| .  |. ||..|||| .|.||| .| |.  .|   ||||. |..  .|..   . |. . |
flnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 554-607 1.2e-13 45.1 In-house 45-95 (95) alignment 
Range on Protein: 554-607
Range on HMM: 45-95/95.0
MRANLTKNRYTDVLCYDHSRVVLAHEdgdEPSDYINANFVDGYKQKNAYISTQG
  ||. |||. ... || .||||.       |||||| ||||| .||.||..||
seanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_ptpA1_pd Subfamily ptpA1 555-766 7.3e-46 151.7 In-house 45-257 (418) alignment 
Range on Protein: 555-766
Range on HMM: 45-257/418.0
RANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNaYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEP---TEE
. | .|||||..|  .|.|| | . .  | |||||||..||   |. .| ||||||.|  |||||.||..| .||| .|  |  |.|| .||      |.
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

SSL------EFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGlgdtwagHPRGPPIVVHC
 |.       || | |  . |  . .  . . ..|     | |.....|.  |||. .|  .  . ..|. . ..| |..           |  ||.|||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiips.......sdrnvpiivhc

SAGIGRTGTFITLDICISRLE
|||.|||||| |  | . .|.
sagvgrtgtfctavimmkkld
subfamily_eak_pd Subfamily eak 555-808 2.9e-18 60.4 In-house 50-308 (332) alignment 
Range on Protein: 555-808
Range on HMM: 50-308/332.0
RANLTKNrYTDVLCYDHSRVVLAHEDgDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSL
  .. .|   ... ||.  | |.     ..  ||||  ..  .  . || |  .  .    ||.|. ||.   ||.    .| .  |  .|.       |
leavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

EFGDYHVRTISVECNEDYMVASLELRniKTDEIRNVSHWQFTSWPDYGVPSS--AMAMLNFLQKVRE-----KQAQLVQGLGDTWAGHPRGPPIVVHCSA
.|| ..| . .   .. . .  |||.  | .|  .| |...  | .. .|     .|. . ...|        ...|.. .   .   |     .. .. 
kfGildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsar

GIGRTGTFITLDICISRLEDVGT--ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR
|  |.|.|. .|. |  ...  .    .   . |..|.| .|. .  |. | . ....|   |
GsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 556-812 3.2e-46 152.5 In-house 32-264 (267) alignment 
Range on Protein: 556-812
Range on HMM: 32-264/267.0
ANLTKNRYTDVLCYDHSRVVLAHEDGDepsdYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERgrvKCGQYWEPTEESSLE
 |  .||. |.| ||..||.|  .. .    |||| .|.|||.|||.| ||.|| .|  ||. .| .|.. |||. |.| .    .  ..| |    . .
knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakk

FGDYHVRTISVECNEDYMVASLELRnIKTDEIRNVSHWQFTSWpdyGVPSSAMAMLNFLQKVREKQaQLVQGlgdtwaghprGPPIVVHCSAGIGRTGTF
. |  |     . ..|| . .|||. .| .  .||. . .  |    . .     |. |  .  |. || .|          ..|.||.||.|.||.|||
yqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilakn.qleng..........nrPlvvacsdGvGrsGtf

ITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAysRGMLQ
...|  . |.   |..||   . ||||||   ..  ..|...|  | |||  .|.|.
lvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya..egrlk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 556-805 3.5e-42 139.1 In-house 54-289 (305) alignment 
Range on Protein: 556-805
Range on HMM: 54-289/305.0
ANLTKNRYTDVLCYDHSRVVLAHEDgdePSDYINANFVDGYK-QKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSL
 . |||||.|| | |.| | |..     ||||| ||.|      .. .| .|||| .| ..|| |. ...   |||  . .| |..|| |||  .    |
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

EFG-DYHVRTIS----VECNEDYMVASLELRnIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlvqglgdtwaghprgpPIVVHCSAGI
|.     |  .|    .| . .  .. |.|     |.   | | |.| ||| |||   .. |..|  .|  .                  ||||||||||
elksgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv.................pivvhcsagi

GRTGTFITLDICISRL-EDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
||||| ....  . .. |.     .   |  .| |||.|||   ||.| |  ...| 
grtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
Y_phosphatase Protein-tyrosine phosphatase 557-802 9.2e-87 285.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 557-802
Range on HMM: 1-234/235.0
NLTKNRYTDVLCYDHSRVVLahEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEF
|..||||.|.|.||..|| |  .. ..||||||||.|.|||.|...| |||||..| .|||||.|.... |||| |...|.||.|| |||. .|| ||..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDYHVRTI-SVE-CNEDYMVASLELRNIKTD-EIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQaqlvqglgdtwagHPRGPPIVVHCSAGIGRTG
||..|..  ...  ...|..  |||.. |.. | | |.....|.|||.|||.|. ..|....||....             ...  |.|||||||.||||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRtg

TFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI
||..|||....||. .. |.  .|...|.||. ..|  .||.|.. |..
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 557-802 9.2e-87 285.7 In-house 1-234 (235) alignment 
Range on Protein: 557-802
Range on HMM: 1-234/235.0
NLTKNRYTDVLCYDHSRVVLahEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEF
|..||||.|.|.||..|| |  .. ..||||||||.|.|||.|...| |||||..| .|||||.|.... |||| |...|.||.|| |||. .|| ||..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDYHVRTI-SVE-CNEDYMVASLELRNIKTD-EIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQaqlvqglgdtwagHPRGPPIVVHCSAGIGRTG
||..|..  ...  ...|..  |||.. |.. | | |.....|.|||.|||.|. ..|....||....             ...  |.|||||||.||||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRtg

TFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI
||..|||....||. .. |.  .|...|.||. ..|  .||.|.. |..
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 557-807 1.5e-68 225.8 In-house 20-266 (270) alignment 
Range on Protein: 557-807
Range on HMM: 20-266/270.0
NLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQ-KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEES--S
. . |||.|.|   ..||.|.... |. . |||||.| |... |..||...|||| | ..|||||||..   ||||| ..|.|| || .|| .  ..  .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

LEFGDYHVRTISVECNEDYMVASLELRniKTDEIRNVSHWQFTSWPDYGVPSSAM------AMLNFLQKVREKQAQLVQGlgdtwaghprgPPIVVHCSA
||.|. .|...| | .| |..  |.|.  .. |.|.. |.....||| |||...        .|. |..||. . .| ..            |..|||||
ledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka...........ePllvHcsa

GIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
|.|||||.|.|||..  ||  . .|.   .|..| .|   .| |.|| | . |..|||  
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 557-803 1.2e-56 186.6 In-house 3-237 (237) alignment 
Range on Protein: 557-803
Range on HMM: 3-237/237.0
NLTKNRYTDVLCYDHSRVVLAHEDGDepSDYINANFVDGYKQ-KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEEsSLE
|  |||| .. .||||||||    ..  ||||||....|.    . ||..||||  . .|||.|.|...| |||| | ..|. ..|| .||  |..    
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paa

FGDYHVRTISVECNEDYMVASLELR-NIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLvqglgdtwaghPRGPPIVVHCSAGIGRTGT
.| . |     |   || | || |  ...  |.| .  .||||||| |||  . |.| | ... ..   .           ..  | ..|||||.|||| 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv...........sesgpwiihcsagvgrtgi

FITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
|. .|  . . ..    ||   |  |  .| | ||  ||||| | ...|
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 557-808 2.1e-52 172.7 In-house 1-174 (182) alignment 
Range on Protein: 557-808
Range on HMM: 1-174/182.0
NLTKNRYTDVLCYDHSRvvlahedgdePSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTrvmergrvkCGQYWEpteesslef
||.||||.|.|.|||||          ..||||||...|.   . .| |||||..|  ||.||..|... .||. |         . .||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gdyhvrtisvecnedymvaslelrnikTDEIRNVSHWQFTSWPDYGVPSsAMAMLNFLQKVREkqaqlvqglgdtwaghpRGPPIVVHCSAGIGRTGTFI
                           ... |.. ......|||.|||.    .|.|...|.|                 .| |..||||||.|||||..
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlv

TLDICISRledvgTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR
 .......       ... .|. .||.|  ....|.||.|..||| |. . .
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 557-804 5.8e-51 168.3 In-house 48-278 (439) alignment 
Range on Protein: 557-804
Range on HMM: 48-278/439.0
NLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRvkcgqYWePTEESsLEF
. ||||| ||  .||.||.|    |   | |||||...|| ... ||.||||  .|..||||...|...  ||| | ..|  .     || |...    .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....yw.psdae.vcy

GDYHVRTISVECNEDYMVASLELRNI--KTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQlvQGLGdtwaghprgpPIVVHCSAGIGRTGT
||  ||.       .|..  . . |   .|.  | | ......|||  ||. |  .|.||. .   . .  .  |          |.|||||||.|||||
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk..eeyg..........pvvvhcsagvGrtGt

FITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
 |.|||.. .|      ||.| |. .| ||   .|   |||| . |..| 
iialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 558-650 3.4e-24 80.2 In-house 48-154 (350) alignment 
Range on Protein: 558-650
Range on HMM: 48-154/350.0
LTKNRYTDVLCYDHSRVVLA--------HEDGDEPSDYINANFVDGY----KQKNA--YISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCG
 .||||...| |.|||| |          .   ...||||||..       ...    ||.||.|||.| .||...| . .  ||.. |  .| .. || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWEPTE
.||.  .
rYWqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 558-650 3.3e-15 50.3 In-house 49-157 (349) alignment 
Range on Protein: 558-650
Range on HMM: 49-157/349.0
LTKNRYTDVLCYDHSRVVLAHE--------------DGDEPSDYINANFVDG--YKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVK
 .|||| |.| |.||||.| .               |.  . ||||||..    .. .. ||.|| ||| | .||...|  .   ...  .   | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CGQYWEPTE
| .||.  .
cdiywqels
subfamily_CG42327_pd Subfamily CG42327 559-720 3.8e-36 119.3 In-house 30-193 (319) alignment 
Range on Protein: 559-720
Range on HMM: 30-193/319.0
TKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQ-KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTE--ESSLE
 |.|. .|.   ..|||| .   |. . |..|..| ||.. .| ||..| .| ..| ||||..|||   |||  | . | |  .| .|. . |  ..   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFtSWPDYGVPSSAMAMLNFLQKVREK
.||. |     | .. |....| |.... .| |...|. .  |.. .||..  |..  | .||. 
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 559-799 5.8e-32 105.6 In-house 52-275 (301) alignment 
Range on Protein: 559-799
Range on HMM: 52-275/301.0
TKNRYTDVLCYDHSRVVLAhEDGDEPSdyINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGD
 |.||  | |  .. | .  .||      | ||...   . . .|.|||||..||.||| |.   .   ||| .. .|.   || .|   . ...|. | 
dkhryptvPckPstavevi.vdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

YHVRTISVEC--NEDYMVASLELRNI-KTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlvqglgdtwaghprgpPIVVHCSAGIGRTGTF
..... . |   |.. .  .||...  .  . | | |.|...|.|.||| | . . .... |.. .                  ||||||||||||. .|
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.................PivvhcsaGiGrsvaf

ITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHL
|. ..  ...|   | ..  .....| .|  ..|.  |  .  |
igteylareveadptieltealkhlrehrwngvqtnsqlywmtl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 560-802 5.2e-19 63.5 In-house 22-256 (290) alignment 
Range on Protein: 560-802
Range on HMM: 22-256/290.0
KNRYTDVLCyDHSRVVLAHEDGDEPSDYINANFVDgYKQKNAYISTQGPLPKT-------SQDFWRMIWEQHCLVIVMTTRVMERGRV----KCGQYWEP
..|..  |   ..||||        .||| ||.|  . .  . | || |. |.        ..|| |. . .   .||.  ..|. .      | .|   
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

TEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIrNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAqlvqglgdtwaghprgpPIVVHCSAG
... .| |..  |.  | | ..|  .  |...  .  |   | | .. .| .  |. .   .|. .|||. ...                 |..|||  |
svgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvkaskt.................pvivHcvdG

IGRTGTFITLDICISRLE-DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI
| |  .. ....    .    |   ..  ....|.|||  |. . .. |   ...
iSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 567-702 5.8e-11 36.8 In-house 3-125 (130) alignment 
Range on Protein: 567-702
Range on HMM: 3-125/130.0
LCYDHSRVVlahedgdePSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERgrvkcGQYWEPTEesSLEFGDYHVRTISV
| .. ||.           .||||.||    . . |. || || .|| |||.|. |..  |.|.   | |       .||  .|   ||. . ..   . 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdse..Plewyeediivtlt

ECNE-DYMVASlELrNIKTDEIR---NVSHWQFTSWPDYG
. .| ... || .| .|. | ..    .. .| . ||  |
drdefknikas.nl.eiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 568-803 6.2e-33 109.3 In-house 1-169 (178) alignment 
Range on Protein: 568-803
Range on HMM: 1-169/178.0
CYDHSRVVLAHEDGDEPSDYINANFVDGYkqknAYISTQGPlpktsQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEEsslefgdyhvrtisve
..|..||.| .  | | ||||||......     |.....|     .|......|... .||. |  .|.|..|| .||   ..                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

cnedymvaslelrniktdeirnvSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQaqlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLDICISRled
                        ..... .||.|||..   .|.|.. ..| .             ...| |..||||||.||.||.. .......   
.......................iqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaaylmkkl...

vgTADIRGTVEKIRSQRAySIQMPDQYVFCHLALIE
    ..   .| .|..|   .. |.|. ....   .
..glsleeaielvrerRp.ivpnpgqlrqLyefelr
0046846 (Phosphotyrosine protein) phosphatases II 579-804 7.5e-41 135.1 In-house 6-172 (176) alignment 
Range on Protein: 579-804
Range on HMM: 6-172/176.0
EDGDEPSDYINANFVDGYKqknaYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLefgdyhvrtisvecnedymvasle
   |...||||||...|..    .| ||||||.| .||..|..|... ..|. |  .| ||.|| .||.  |. ..                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lrniktdeirnvsHWQFTSWPDYGVPSSaMAMLNFLQKVREKQaqlvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRledvGTADIRGTVE
             ..... |||.|||..  ..|..|. .|| .               .| |..||||||||||||.. .......       ..  ...
.............qylhlpwpDhgvpdl.elllellefireal..............keggpvlVHCsaGigRtgtlvaayllele....kglsveeala

KIRSQRA-YSIQMPDQYVFCHLALIEY
..|.||  ...| |.|| |.. .. ..
lvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 581-798 3.5e-44 145.9 In-house 1-154 (172) alignment 
Range on Protein: 581-798
Range on HMM: 1-154/172.0
GDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVmergrvkcgqywepteesslefgdyhvrtisvecnedymvaslelR
|||.||||||...|.|   . .| |||||. |  |||||..|... .||. |.                                               
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

NIKTDEIRNVSHWQFTSWPDYGVPsSAMAMLNFLQKVRE--KQAQlvqglgdtwaghprGPPIVVHCSAGIGRTGTFITLDICIsrledvGTADIRGTVE
...... |.. ......|||.||| ..  .|.||. ..|   . .              | |..||||||.|||||.. .....         ..  .|.
ydpellerlgiqylylpwpDhgvp.llellleflefidellalsp..............ggpvlVHCsaGvgRtgtlvaaylml......lglsleeava

KIRSQRAYSIQMPDQYVFCH
 .|..| ...| |.|| |..
lvrekRpgavqnpsqyrfly
0051082 (Phosphotyrosine protein) phosphatases II 584-802 2.9e-34 113.2 In-house 2-150 (151) alignment 
Range on Protein: 584-802
Range on HMM: 2-150/151.0
PSDYINANFVDGYkqknaYISTQGPLPktsqDFWRMIWEQHCLVIVMTTRVMERGrvKCGQYWEPTEesslefgdyhvrtisvecnedymvaslelrnik
 |||||...|.|.     .. ..|||.    ||.....|... .||. .  .|||  .| .|.. ..                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tdeiRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREkqaqlvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRledvgtADIRGTVEKIRSQ
    ..| |.....|||.|.| |  |.|.||.....                ... |..||||||.|||||.. |.... .       ..  ..| .|..
....ievlhipildwpdpglplsfdavleflellld................kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlk

RAYSIQMPDQYVFCHLALI
| ...| ..|..|...||.
rpgvvqpnqqflfqlfall
0051429 (Phosphotyrosine protein) phosphatases II 585-807 8.3e-53 175.0 In-house 4-227 (272) alignment 
Range on Protein: 585-807
Range on HMM: 4-227/272.0
SDYINANFVDGYKQ---KNAYISTQGPLPKTSQDFWRMiWEQHCLVIVMTTRVMERGRVKCGQYWE----------PTEESSLEFGDYHVRTISVECNED
|.||||..|.|| .   ..... ..|||| | .||||. .|... .||. ....||||.|| .||.          .... . ..|...|...|.|. .|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YMVASLELRNI-KTDEIRNVSHWQFTSWPDYGVPSSAmaMLNFLQKVREkqaqlvqglgdtwaghprGPPIVVHCSAGIGRTGTFITLDICISRLEDVGT
|..  |.|... ...|.| | |...|.|||.|||..|  .|..|. ...                  | |..||||||..||||.. |.... ....   
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..................ggpvlvHCsaGkdRTGtvvallllllgvsleti

AD--------IRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYS
.|        ....||..|.||....| ..||.|.. ||.|...|
vddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 585-798 3.6e-46 152.4 In-house 2-163 (174) alignment 
Range on Protein: 585-798
Range on HMM: 2-163/174.0
SDYINANFVDGYKQKNAYISTQGPLPktsqdFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPteesslefgdyhvrtisvecnedymvaslelrnIKT
||||||...|..   . .| .||||.     ||.|..|... ..|| .. .|.|..|| .||                                    ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DEIRNVSHWQFTSWPDYGVPSSAMaMLNFLQKVREKQAQlvqglgdtwaghPRGPPIVVHCSAGIGRTGTFITLDICISRLEdVGTADIRGTVEKIRSQR
|. |.. ..... |||.|||.... .|.|.. |.| ...            ..| |..||||||.|||||.. ..... .|.  .. |.  .| ..|.||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse............dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqr

AYSIQMPDQYVFCH
 ...|.|.|| |..
pgmvqtpsQyrfly
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 587-702 3.9e-11 37.0 In-house 124-234 (244) alignment 
Range on Protein: 587-702
Range on HMM: 124-234/244.0
YINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERgrvkcGQYWEPTEEssLEFGDYH--VRTISVECNEDYMVASLELRNIKT
|||| ||    .   || || ||  || |||.|. |.|  |.|.   | |       .||  .|   ||. .    |     .   .   . ||.     
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep..lewyeeditvtltdrdefknikasnleiesdmn

DEIRNVSHWQFTSWPDYG
.  . .. .| . ||  |
eshqaltmfqisnwpsdg
0049260 (Phosphotyrosine protein) phosphatases II 592-798 3.5e-39 129.3 In-house 1-143 (152) alignment 
Range on Protein: 592-798
Range on HMM: 1-143/152.0
FVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWepteesslefgdyhvrtisvecnedymvaslelrniktdeirnvs
|.|||......| ||||.| |  |||||..|... .||| |. .|.|..|| ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HWQFTSWPDYGVPSSAMAMLNFLQKVREKqaQ-LvQ-GlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICIsrledvGTADIRGTVEKIRSQRAYSIQ
..... |||.|||.... .| .|. ...   .   . |            |..||||||.|||||.. .....         ..  .|. .|..| ....
qylhlpwpDhgvpdlsqlllflllfiekl..ald.kgg............pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavp

MPDQYVFCH
 |.|. |..
npgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 593-688 7.2e-12 39.3 In-house 229-321 (440) alignment 
Range on Protein: 593-688
Range on HMM: 229-321/440.0
VDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERgrvKCGQYWePTEESSLEFGDYHVRTISVECNEDYMVASLELRNI-KTDEIR
..|| .|||.|.|| ||  |  ||||.. . .   |.|  .. ..    |  || | .  |. || . |     |  .   | .|||.   .  |||
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiyw.pvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheir
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 594-799 6.3e-19 62.5 In-house 84-282 (302) alignment 
Range on Protein: 594-799
Range on HMM: 84-282/302.0
DGYKQKNAyISTQG--PLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECN-------EDYMVASLELRNIKT
|| ..|.  .| .   |  .| . .| .| . .  ..|  . ..| .  || .|.    .  |.|| | |.|.||. .       ..... ..|..| |.
dGtekkek.vskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

DE--IRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVrEKQAQLvqglgdtwaghprgppIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRS
 .   . |.  .|..|||.| |  | . |. |.   |   .                 ..||||||.|||||....   |       ..|.   |  .|.
kkkvkktvdilafsawpdhGapkeaytaldilkfc.esykkn................vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrq

QRAYSIQMPDQYVFCHL
 |  ..|  .| ..  |
cryGavqdeqqliylll
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 597-794 3.1e-25 83.5 In-house 2-193 (199) alignment 
Range on Protein: 597-794
Range on HMM: 2-193/199.0
KQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTD--EIRNVSHWQ
| .  ||.|| || .|  |||.|.||     |||         .    ||  || .. ..|   | | .. .. || ...| | |  |     |..||.|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDYGVPSSAMaMLNFLQKVREKQAQLVQGlgdtwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTA--DIRGTVEKIRSQRAYSIQMPD
|||| .   |  |. .. |.   ||   .  |          .  |..|||| | | || |..||| .   |.  |.  |.     ..|  |   |   .
ftswkekttpnval.fvgfvvasrevskkyeqe.........kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QY
.|
hy
subfamily_hpo-7_pd Subfamily hpo-7 597-721 2.1e-10 34.9 In-house 35-155 (263) alignment 
Range on Protein: 597-721
Range on HMM: 35-155/263.0
KQKNAYIStqgpLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECneDYMVASLELRNIKT--DEIRNVSHWQ
|.|| |.     | .| . |...|  .   |.|| .   | |..|| .|.    .  . . .  | |  |    | .. .||| ..     ....| |..
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhys

FTSWPDYGVPSSAMAMLNFLQKVREKQ
.. |..   |  |  .|| |. .|. .
ykgWiekndpelareilnilkvarnsk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 597-725 3.3e-10 34.5 In-house 32-153 (255) alignment 
Range on Protein: 597-725
Range on HMM: 32-153/255.0
KQKNAYIStqgplpkTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISveCNEDYMVASLELRNIK--TDEIRNVSHWQ
|.|| |.        | . |...|  .   |.|| .   | |..|| .|.    .  | . |  | |       | ..  ||.        . ..| |..
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhys

FTSWPDYGVPSSAMAMLNFLQKVREKQAQLV
.. |..   |  |  .|| |. ||. .. .|
ykGWieknaPelareilnilkvvrdsksvvv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 599-794 4.2e-25 83.1 In-house 3-192 (198) alignment 
Range on Protein: 599-794
Range on HMM: 3-192/198.0
KNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTD--EIRNVSHWQFT
.  ||.|| || .|  |||.|.||     |||         .    ||  || .. ..|   | | .. .. || ...| | |  |     |..||.|||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDYGVPSSAMaMLNFLQKVREKQAQLVQGlgdtwaghpRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTA--DIRGTVEKIRSQRAYSIQMPDQY
|| .   |  |. .. |.   ||   .  |          .  |..|||| | | || |..||| .   |.  |.  |.     ..|  |   |   ..|
swkekttpnval.fvgfvvasrevskkyeqe.........kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy
0048179 (Phosphotyrosine protein) phosphatases II 660-799 1.8e-23 78.3 In-house 32-139 (144) alignment 
Range on Protein: 660-799
Range on HMM: 32-139/144.0
HVRTISVECnedymvaslelrnIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKqaqlvqglgdtwagHPRGPPIVVHCSAGIGRTGTFITLD
.| ... |.              .....|.. ......|||.|||...  .|.||. ..|               ...| |..||||||.|||||.....
tvinlteey.............epefleregiqylhlpwpDhgvpdllellleflefieea..............leeggpvlVHCsaGvgRtgtlvaay

ICIsrledVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHL
...     .   ..  ... .||.| .... |.|. |...
lmk.....klglsleealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 666-803 5.2e-25 83.2 In-house 36-141 (145) alignment 
Range on Protein: 666-803
Range on HMM: 36-141/145.0
VecnedymvaslelRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQlvqglgdtwaghprGPPIVVHCSAGIGRTGTFITLDICISrl
.              . .... |.. ......|||.|||...  .|.||. ..| ...              | |..||||||.|||||.. ......  
l.............tselellerlgiqylylpwpDhgvpdllellleflefieealke..............ggpvlVHCsaGvgRtgtlvaaylmll..

edvGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
      ..  ..|..|||| .... |.|. |..... |
...lgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 671-805 1.5e-15 51.4 In-house 76-194 (440) alignment 
Range on Protein: 671-805
Range on HMM: 76-194/440.0
DYMVASLelrnIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGlgdtwaghprgpPIVVHCSAGIGRTGTFITLDICISRLEDVGT
||. ||     |.  | | . .... .||| |||  |  .|...| | | | .  .|            |..|||||| ||||  |..|  .   .    
dyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagng............pllvhcsagagrtgviiavdsilreakrsdq

ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
 ||   .. .|..|   .| |.||.| | |..|  
idifsfinsmrnnrpqmvqtpeqyafvheavlegl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 683-766 3.5e-11 37.0 In-house 213-293 (349) alignment 
Range on Protein: 683-766
Range on HMM: 213-293/349.0
KTDEIRNVSHWQFTSWPDYgvpSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLE
....   .   |.  |.|    |  .    .|| .  |.  . .   . .    . ....|||||| ||||...|||. .| ||
avekPyellqlqvknwldl...slllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 686-804 3.8e-16 53.7 In-house 214-343 (350) alignment 
Range on Protein: 686-804
Range on HMM: 214-343/350.0
EIRnVSHWQFTSWPDYGVPSSAMAMLNFLQkvrEKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICIS---RLEDVG-----------TA
    | . |.  |.| ..      .|. |.    |.  . .    ..    |..||.||||||.|||||..|||  .|    || .            | 
Pyv.vyqlqvknWkDlslllnPesilqale...vkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktr

D-IRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY
| |  .| ..|.||   .|  ||..|.. ||  |
DlisiivnelrkqrismvqnldqfifiYeallfy
PTPc_DSPc_SM00012 690-802 7e-33 108.3 In-house 2-104 (105) alignment 
Range on Protein: 690-802
Range on HMM: 2-104/105.0
VSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQglgdtwaghprGPPIVVHCSAGIGRTGTFITLDICISRLEDV-GTADIRGTVEKIRSQRAYSI
|.| ..|.||| |||... ..|..|..|.... .  .           ..|.|||||||.||||||..|||....||.  .. ||  .|...|.||. ..
vkhyhytgwpdhgvPeesdsilellravkknknkses...........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmv

QMPDQYVFCHLALI
|. .||.|.. ||.
qteeqylflyrall
0038934 (Phosphotyrosine protein) phosphatases II 698-758 7.5e-07 24.5 In-house 87-135 (194) alignment 
Range on Protein: 698-758
Range on HMM: 87-135/194.0
WPDYGVPSSAMAMLNFLQKVREKQAQLVqglgdtwaghprGPPIVVHCSAGIGRTGTFITL
.||.|.. |   .|.||. | |. ..              |  ..||| ||.|||||..  
fpddgtvPsleillrfldlvdeflnedp............ggvvaVHCkaGlgRtGtlvaa
subfamily_PTPDC1_pd Subfamily PTPDC1 738-798 2.9e-06 21.9 In-house 115-169 (182) alignment 
Range on Protein: 738-798
Range on HMM: 115-169/182.0
GpPIVVHCSAGIGRTGTFITLDICISRleDVgTADirGTVEKIRSQRAYSIQMPDQYVFCH
|  . ||| || ||||  |.  .  ..  .. ||.   .....||.|. |||  .|  ...
g.kvavhChaGlGrtGvliacylvyak..rl.tae..kaiklvrskrpksiqtreqvelvk
subfamily_CG42327_pd Subfamily CG42327 739-805 8.5e-17 55.8 In-house 248-315 (319) alignment 
Range on Protein: 739-805
Range on HMM: 248-315/319.0
PPIVVHCSAGIGRTGTFITLDICISRLEDV-GTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYA
 |.||||| |.||||. |. || | .||.   . ||  .|  .| .|| ...  .|| | .  | |||
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 740-811 8e-07 23.4 In-house 150-227 (255) alignment 
Range on Protein: 740-811
Range on HMM: 150-227/255.0
PIVVHCSAGIGRTGTFITLDICIS----RLEDVGTA--DIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGML
..|||||.||||. .|.  ..        |.   |.  | .  .|..||.|. .|. | |  |. | .... . .| |
svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgel
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 741-803 1.3e-10 35.5 In-house 1-63 (69) alignment 
Range on Protein: 741-803
Range on HMM: 1-63/69.0
IVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
.|||||.| |||||||.. . ..|.      ||   |  .|  |   .    .|.| | ||.|
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 742-803 3.8e-10 34.0 In-house 1-62 (69) alignment 
Range on Protein: 742-803
Range on HMM: 1-62/69.0
VVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE
|||||.| |||||||.. . ..|.      ||   |. .|  |   .   ..|.| | ||.|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve