Gene Ptp99A in Drosophila melanogaster

Synonym: CG11515, CG11516, CG11517, CG2005, CT6383, DPTP99A, DPTP[[99A]], Dmel\CG11516, PTP99A, R-PTP 99A, dptp99A, ptp99A, Dmel_CG11516, Ptp99A

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP050_AA protein Get Run
DmelP050_AA_629-914 phosphatase_domain Get Run
DmelP050_AA_919-1188 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 142-228 4.6e-14 45.5 Pfam-A 2-85 (85) alignment 
Range on Protein: 142-228
Range on HMM: 2-85/85.0
PPERPLLISFTSRSVNLSWAHSQhPRNAPVTHFIIETREGEDGIweQLARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPS
.||.. ... ||.|..||| ... ....|.|.. .| || ..|   .  .. .. ..||...|||.| | |.||. |||. | .|.|
aPenlsvsevtstsltlsWsppk.dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 248-330 1.4e-15 50.4 Pfam-A 6-84 (85) alignment 
Range on Protein: 248-330
Range on HMM: 6-84/85.0
TTAHNTSSTSVYISWKAPPpdTILGEFLGYRITYRPRDRDPnDTKEIYiRDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPE
 ......|||. .||..|.  .  |.. ||...||. .    ..||.  ...| .|.....|. .|.|...||  | .| |||
lsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.ewkeft.vprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 343-430 2.5e-19 62.4 Pfam-A 1-85 (85) alignment 
Range on Protein: 343-430
Range on HMM: 1-85/85.0
SKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGveiVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPS
|.|.||.. .|...|.|.|| |||...| | || |   ......   ......  .|  ...|..|.|.|.|.. |.| ... ||..|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 443-522 1.2e-06 21.7 Pfam-A 1-77 (85) alignment 
Range on Protein: 443-522
Range on HMM: 1-77/85.0
SAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDThRDIRINASAKelETAMILQNLTTNSYYEVKVAAAT
|||  ....  .  |.|..|  | .   .|. | .. | .|.    . ......   .| ..|..|. .. ||..|.| .
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprt..ttsvtltgLkpgteYefrVqavn
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 622-919 7.2e-91 299.5 In-house 4-296 (298) alignment 
Range on Protein: 622-919
Range on HMM: 4-296/298.0
EIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECI-SDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINANFIDGYQKGHAFI
||.|    . . | .|  .. . .|.. |.. ...     ..   | ...||||.|||| .| |.|.||| |. .  .... ||||| |...|.. .|||
eieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrnafi

GTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKhlklkKKKQCnTEKLVYQYHYTNWP
 ||.||. |.  ||||..|. .. |||.|||.| .. |.  |||..| |||| |.|.| ..|... ..||.|...     |||.  .|. | | |.|.||
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvs.....kkkee.kerevrqlhftsWp

DHGTPDHPLPVLNFVKKSSAaNPAEAG--PIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGET
|.|.| .   ||....|  | .. .||  |..|.|||||||.||.|..|..| ...... | ||  .. .|..|  .|||||||.|...|  ||..|...
dkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

N
.
e
subfamily_PTPRD_pd Subfamily PTPRD 625-926 2.6e-132 437.3 In-house 3-294 (564) alignment 
Range on Protein: 625-926
Range on HMM: 3-294/564.0
AAVPVNEFAKHVASLHADGDIGFSREYEAIQNEcisDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQkKNLDYINANFIDGYQKGHAFIGTQG
 ..||.|...|||.|.|..|. |..||. |...   .  ..|....|.||.|||| ||.||||||| |....|. .. |||||.|||||.| .|.| |||
kpipvaelkehvaklkansdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqg

PLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKlkkkkqCNTEKLVYQYHYTNWPDHGT
||..|.. ||||.|||....|||.|.|.|.|. ||..|||..| |||| ..|.| ||| ...|..||...|. |       .  . | |.|.|.||||| 
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgv

PDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQ
|... ..|....|..|.|. .|||||||||||||||||.||.||||..|.... |.........|.|||..|||||||||.|.|..||.|.|.|.. .|.
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesen

VE
..
lk
subfamily_PTPRA_pd Subfamily PTPRA 625-926 1.7e-96 318.0 In-house 12-308 (330) alignment 
Range on Protein: 625-926
Range on HMM: 12-308/330.0
AAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDdlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKkNLDYINANFIDGYQKGHAFIGTQG
  .||... . .    ||    |  |..|.    |     .| ... |||.|||..||  ||.|||.| .  |.. . ||||| |||||.. . || .||
fplpvekleeeirirsaddnklfreefnalPagpiqa..tlelaskeenkeknrvvnilPydfsrvilsvkeGve.esdyinasfidGykekdkfiaaqG

PLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKhlKLKKKKQCNTEKLVYQYHYTNWPDHGT
|. .| . ||||||||. | |||.|.| || . ||  |||..|. ||| |.|.. .|.|.  |||| . ..  .| .... ....|| |.|.| ||| | 
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvGv

PDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQ
| .|  .|...||  . |. .|||||||||||||||||.|||||.|.... ...|.||.|....|.||  .|||.||| |.. .| |    |.|.| .  
PfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss

VE
.|
le
subfamily_PTPRB_pd Subfamily PTPRB 626-917 1.1e-104 344.6 In-house 6-289 (293) alignment 
Range on Protein: 626-917
Range on HMM: 6-289/293.0
AVPVNEFAKHVASLHADGDIGFSREYEAIQNecISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQkKNLDYINANFIDGYQKGHAFIGTQGP
 . ...|..||....|| |..|| ||| ...  .  |  .. .....|. |||| || .||||||.|... .. .. ||||||.|.||.  . || ||||
piklekfeehvkkmkadsdlrfseeyeelka..vgkdqavkaaelavnraknrytnilpydhsrvkLaalkde.sgsDYinanyipgynsprefiatqGP

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD-GVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkkkqCNTEKLVYQYHYTNWPDHGT
||.|.| ||||.||... ||||.|.|||.|. ||. |||.|    .|| |.|.|..||... ...|.|.|..         ..|. | |||.| ||||| 
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek........ekeerkvrqyhftsWpdhgv

PDHPLPVLNFVKKSSAA--NPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGE
|... ..|.||..   |  . |...|||||||||||||||.| || .|..|.....|..||.. ..| .||.|||||.||||.|..... . ..|
PektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0051299 (Phosphotyrosine protein) phosphatases II 626-913 1.3e-104 345.0 In-house 4-286 (288) alignment 
Range on Protein: 626-913
Range on HMM: 4-286/288.0
AVPVNEFAKHVASLHADGDIGFSREYEAIQNECISddLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNlDYINANFIDGYQKGHAFIGTQGP
...|.|..|.|  |.|.|  |. .|.|.... ...  |.. ....|||. |||| .| .||||||.|....|.  . |||||..||||.....|| ||||
eisveellklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegs.dYinAsyidgynlkrkfIatqgP

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKkkQCNTEKLVYQYHYTNWPDHGTP
||.|.. ||||.|||.| .|||.|.|||.||.||. ||| .|..||| |.|.|..|||...||||||....|.| .  ...... |...|||||||||.|
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld..gdgesrtvthfhytnwpdhgvp

DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
|.| ..|.|...   |...  ||.|||||||||||||.|.|| .| |..... |.|.......| ||...|||.|||.|...||.|..
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 626-924 7.9e-103 338.9 In-house 4-294 (319) alignment 
Range on Protein: 626-924
Range on HMM: 4-294/319.0
AVPVNEFAKHVASLHADGDIGFSREYEAIQNEcISDdlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqKKNLDYINANFIDGYQKGHAFIGTQGP
 ..|.|.....  |.. |. .. .|.. ...   .|    ......|||.|||| || |||..|| | . .| ... |||||.||||||. ..|| ||.|
eievqeLkerlkalastgetllekefkllkea.vnd..tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqerekfiatqaP

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKhlklKKKKQCNTeKLVYQYHYTNWPDHGTP
| .|.. ||||.||... |.||.|.|||... |.  |||.  .|.|| . |.| ||| .. | .| |...    ||. . .| . | ...||.||||. |
lentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkln....kkssevet.RevkhfqyteWpdhdvP

DHPLPVLNFVKKSSAANPA-EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQ
.. . .|...|.   .    ..||||||||||||||||.||||||| .... ....|| . ...|.|||..||..|||.|...||.||. .|.|..  ..
ekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqd
subfamily_Ptp69D_pd Subfamily Ptp69D 626-927 8.8e-92 302.5 In-house 3-300 (307) alignment 
Range on Protein: 626-927
Range on HMM: 3-300/307.0
AVPVNEFAKHVASLHADGDIGFSREYEAIQNEciSDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKkNLDYINANFIDGYQKGHAFIGTQGP
|... . .. . | . | | |. .||| ....    |. .. |.. ||. |||| .|.|.|. || |....|.. . |||||.|| ||.. . ||  |.|
aiaiddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingke.dsdYinasfikgykekkkfiaaqdP

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKkKQCNTEKLVYQYHYTNWPDHGTP
.  | . |||||.|| | .|||..|| |  |.||. |||..    || | |||..|| .| |. |.|.. . | .   . . .. | |||||.|.|   |
veatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvP

DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQV
...  .|.....    .  . .||||||||||||.|... || .|.|... . |..| . ...| |||.|||  |||.||. ||.. .  |.|.   ...
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl

EE
|.
ed
subfamily_PTPRK_pd Subfamily PTPRK 626-927 6.8e-91 299.4 In-house 3-291 (314) alignment 
Range on Protein: 626-927
Range on HMM: 3-291/314.0
AVPVNEFAKHVASLHADGDIGFSREYEAIQNEcisddlpCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKkNLDYINANFIDGYQKGHAFIGTQGP
|. |..  ...| |..    || .|||.. .         . ... ||..|||. .| |||.||| |... |.  . |||||..||.|.. .||| ||||
airvadllqsiallkraegygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgdp.ssdyinaalidsykrpaafivtqgP

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVEtYGVIQVKLIEEEVMSTYTVRTLQIKHlklkKKKQCNTEKLVYQYHYTNWPDHGTP
|..|   |||...... | |||.|.||| || ||  |||.|.   || |.|.|.| |. . . ||......     ... .  ..| |.....||||..|
lqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek....largqeeirevrqfqflgWpdhdvP

DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQV
 .   .|..|..  . .. |||.|||||||| |||||.|..| .|  |.....|.||   . .|...  .|.|||||.|..|...||   ||| . . ..
vsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef

EE
. 
ka
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 626-921 1.7e-84 278.5 In-house 5-287 (315) alignment 
Range on Protein: 626-921
Range on HMM: 5-287/315.0
AVPVNEFAKHVASLHADGDIGFSREYEAIQNECISddlPCEHSQHPENKRKNRYLNITAYDHSRVHLhPTPGQKKNLDYINANFIDGYQKGHAFIGTQGP
 .|....  .||  .|    || ..||.|    .    | . ... |||.|||| || |||.|||.| |   .... ||.||||||||.| . .|..|||
pipldqlityvaqkkastkngfkqdyesipggqlh...pldvakkienkqknryiniiaydksrvql.pllendphsdyvnanfidGynkkrryiaaqgp

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVeTYGVIQVKLIEEEVMSTYTVRTLqikhlKLKKKKQCnteKLVYQYHYTNWPDHGTP
.. . . |||...|. .. |||.|||||. .||.. ||| . | .|| | | ...||| . ||||||         ...    . |.|.||| ||| | |
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkv.iyGkitvtrkseevnteytvrtl.....svvfgdni...revvqlhytswpdmgvp

DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLM
 . .|..|....    . ...|.||||||||||||||.| |||.|.|.. .|...|. |.. .|..|  .||. ||| |..|||.|..  |.|.. 
kytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia
subfamily_PTPRG_pd Subfamily PTPRG 627-1189 0.0 1226.2 In-house 1-563 (563) alignment 
Range on Protein: 627-1189
Range on HMM: 1-563/563.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPL
|||.||||||||||||||||||.|.||.|.|.||.||..||||.||||||||||||.|||.|||.|.|.||.||.|||||||.||||||..|||.|||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPD
.||||.||||||||.|||||||||||||||||||.|||||..||||..||.||||||...||||||.||.|||||||||.|||||.|||||.|||||.|.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVE
|.||||.|||||||||.||||||||||||||||||||||||..||||||.|.|||||||.|||||||||||||||||||||||.|||||.||.|.|||||
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

ELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHN
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||..||||||||||||||||||||||||||||||||
elknctpyleqqykniiqfqpkdihiasamkqvnsiknrgaifpiegsrvhltpkpgedgsdyvnalllhgfrrlrdfivtqhpmahtikdfwqmvwdhn

AQTVVLLSSLDDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPIVI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
aqtvvllsslddinfaqfwpdeatpiesdhyrvkflnktnksdyvsrdfviqsiqddyeltvkmlhcpswpemsnpnsiydfivdvhercndyrngpivi

VDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFLPG
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vdryggaqactfcaisslaiemeycstanvyqyaklyhnkrpgvwtssedirviynilsflpg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 627-926 3.7e-116 382.6 In-house 2-293 (318) alignment 
Range on Protein: 627-926
Range on HMM: 2-293/318.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNEciSDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKkNLDYINANFIDGYQKGHAFIGTQGPL
..|.....||. |...|.. .|.|||... .  ..     .| .| ||.|||| ||.||||.||.|... |.. . ||||||.||||.. .|.| .|.||
isvedleshvrrlresGelllseeyerlsrs..eetvtslkslepvnkaknryanilaydhtrvkLqmlegee.gsDyinanyidGyrrkkayiaaqaPl

PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkkKQCNTEKLVYQYHYTNWPDHGTPD
|.|.. ||||.|||  |.|||.|...|||..|.. |||..| ..|| ..|.| ||  .|.|..|......      .... .. | |||||.|||.|.|.
petieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr......teeeesrqvrqyhytsWpdegvpe

HPLPVLNFVKKSSAAN-PAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQV
..  .|..|...|.|. ...||||||||||||||||..|..|..|..|.. ..|.||.. ...| ||| .||||.||.|..|.|.||.|||.|.  |...
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdl

E
 
r
0050432 (Phosphotyrosine protein) phosphatases II 627-916 5.7e-101 333.1 In-house 26-302 (308) alignment 
Range on Protein: 627-916
Range on HMM: 26-302/308.0
VPVNEFAKHVASlhADGDIGFSREYEAIQNECIsdDLPCEHSQHPENKRKNRYLNITAYDHSRVHLhptpgqKKNLDYINANFIDGY--QKGHAFIGTQG
..| ...|.. .  |..  ....|.|.... ..  .|.......|||| |||| .| .||||||.|      ... |||||...|||   . ..|| |||
lsvldllkllek..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqg

PLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD---GVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKlkkkkqCNTEKLVYQYHYTNWPD
|||.|.. ||||.|||.| .|||.|.|||.|| ||. ||| .   |...|| ..|.|..|||...||||||....|.      .. .. |...|||||||
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg......dgesrtvthfhytnWpd

HGTPDHPLPVLNFVKKSSAANpaEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG
||.|..| ..|.|...    .  . ||||||||||||||||.|.|| .| |..... |.||. ....| ||.. |||.|||.||..||.| . . 
hgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0045450 (Phosphotyrosine protein) phosphatases II 627-913 3.2e-96 317.9 In-house 9-304 (307) alignment 
Range on Protein: 627-913
Range on HMM: 9-304/307.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFI--------DGYQKGHA
...  . ..|. |..|.  |. .|.| ...... .  .......|||| |||| .| .|||.||.|....|. .. |||||...        ||| ....
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE-TYGVIQVKLIEEEVMSTYTVRTLQIKHLklkkkKQCNTEKLVYQYHYT
|| ||||||.|.. ||||.|||.| .|||.|.|||.||.||..||| .| | ||| ..|.|..||... |||||| ...|     .... .  |...|||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.....dgtgesrtvthfhyt

NWPDHGTPDHPLPVLNFVKKSSAANPA--EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEA
.|||||.|... ..|.|...  .|. .  . ||..||||||||||||.|... ||.|... ..   |...  ....|.||   ||..|||.||..|| | 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

I
.
l
0043336 (Phosphotyrosine protein) phosphatases II 627-911 2.2e-94 311.2 In-house 2-275 (278) alignment 
Range on Protein: 627-911
Range on HMM: 2-275/278.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNECIsddLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqKKNLDYINANFIDGYQKGHAFIGTQGPL
..|....|... |....  ....|.| ...  .    .......|||| |||| .| .||||||.|....|   ..|||||...|||.....|| |||||
isvkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllgg.dldsdYinAsyvdgynvprkfiatqgPl

PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPkDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkkKQCNTEKLVYQYHYTNWPDHGTPD
|.|.. ||||.||..| .|||.|.|||.|| ||. ||| .|..||| ..|.|..||....|||||| ...      .... .. |..|||..|||||.|.
petvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn......lgdgesrtvthyhylgwpdhgvpe

HPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
.. ..|.|.|.   |.. . ||..||||||||||||.|.|. .| |..    |...  ....| ||   |||..||.||..|| |
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 627-924 9.3e-86 282.7 In-house 4-294 (305) alignment 
Range on Protein: 627-924
Range on HMM: 4-294/305.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNEcisdDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKkNLDYINANFIDGYQKGHAFIGTQGPL
. ....|... . ... | |.  .|.....|    . ...  .. .||.|||. .|| .|..|..| ... .. . |||||...|||.. ...| .||||
ialddlaayikearvysdkgleaqykslyee....eesidvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPl

PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE--TYGVIQVKLIEEEVMSTYTVRTLQIKHLKLkkkkqCNTEKLVYQYHYTNWPDHGT
..| . |||.|.| .|  |||.|.||| |. || .|||.   |   .| ..|.| .|. .| |. | |.|   .       . .. | ||. |.||||| 
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGv

PDHPLPVLNFVKKSSAANPAEAG-PIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAE
|. .  .|...|.   .   . | |..|||||||||||..|..| .| .... ..|.||. |...| .|  .||| .|| |||||| | | .|.|... .
pqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigs

Q
 
n
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 627-918 5.6e-75 246.9 In-house 2-288 (290) alignment 
Range on Protein: 627-918
Range on HMM: 2-288/290.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNecISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKK-NLDYINANFIDGYQKGHAFIGTQGP
.||..|...||  || |. ||  .......   . .   ..   ..||..||. ||  ||  |. |.| .|.|  . .|||| .|.||.. ...| ||||
ipvdkfgefvanghakgnegfrnqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgp

LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkKKKQcNTEKLVYQYHYTNWPDHG-T
...|   ||..||...|.||||.|| .| |. ||  |||. ....|| ...||..||....|. |.|..|.    |... .... | ||. |||...|  
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevkn....knsa.gakqsvtqyqitnwdstgkv

PDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGET
...   .| . .          ..||||||..|||........  ... ...  ..||  |.. | |.  .|||..|| .... ..... | ||
tnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 627-919 3.1e-70 231.4 In-house 2-284 (287) alignment 
Range on Protein: 627-919
Range on HMM: 2-284/287.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDlPCEHSQHPENKRKNRYLNITAYDHSRVHLHptpgqKKNLDYINANFIDGYQKGHAFIGTQGPL
.||..|.. ||. || |. ||.  .  ...   ..|    |.  ..|| |||. .|  .|  || |.     ... ||||| |||||.. .||| ...|.
ipvekfgefvakghakgnegfknqftvleqvtqred.evthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesPm

PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKlkkkkQCNTEKLVYQYHYTNWPDHG-TP
 .|   ||..|....| .|||.... |  ...|  |||..   ..|  ...|..|||.. |..|.|..|. .     . .... | ||..|||...|  .
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.....kagdkqqvkqyqitnWdstgkvt

DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETN
..   .| . ..  .      ..||||||..|||.....  .  ... ..  ...||  |.. | |.   ||| |||.|. |...| . |.||.
epqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 627-926 1.8e-68 226.0 In-house 5-301 (325) alignment 
Range on Protein: 627-926
Range on HMM: 5-301/325.0
VPVNEFAKHVASLHADGDIGFSREYEAIQNeciSDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHpTPGQKKNLDYINANFIDGYQKGHAFIGTQGPL
. | .. .||   .|. . ||..|.. . .    |    . . .|||| |||. |. |.|.||| |  | ... . |||||...  ..| . |. .| ||
iavvnlvehvekkkaqdqdgfahefgllps...ddgiakkvamkpenkaknrfknvvaldksrvvle.tkkddpssdyinasylrddkkkdvflaaqaPl

PDTFDCFWRMIWEQRvAIIVMITNLVERGRRKCDMYWPKD--GVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKlkkkkQCNTeKLVYQYHYTNWPDHGT
..| . .||.. . | . .|...| .. |  .| .||||.     |.| ..|||.  | .| |  | |..|  |     . .| . | |...  |.| |.
tatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.....kGet.rsvkqfqlqswddmGv

PDHPL---PVLNFVKKSS---AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGET
. .|    ..|. ||. |    ||   ..||.|||||||||||..| | ..|... ..  |..|||....|..|  .|.| .|||....|||||. ||.|
qkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgnt

NLMAEQVE
..    .|
dvpvssfe
0039614 (Phosphotyrosine protein) phosphatases II 628-914 2.8e-93 307.9 In-house 15-290 (297) alignment 
Range on Protein: 628-914
Range on HMM: 15-290/297.0
PVNEFAKHVASLHADGDIGFSREYEAIQNECIsdDlpCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQK-GHAFIGTQGPL
|.. .. ..  ..|..  .. .|.| ...  .  |  ......|||| |||| .| .||||||.|.| .|.  ..|||||...||| . ...|| |||||
plsvldlllllekansktllllefeellslkp..d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PDTFDCFWRMIWEQRVAIIVMITNLVERGRrKCDMYWPKDGVeTYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkkkqCNTEKLVYQYHYTNWPDHGTPD
|.|.. ||||.|||.| .|||.|.|||.|| ||. ||| .|  ||| ..|.|...|. . |||||| ...         . .. |....||.|||||.|.
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn........ngesrtvthfqytgwpdhgvpp

HPLPVLNFVKKSSAANPA--EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
..  .|.|...   |. .  . ||..||||||||||||.|... || |.. .  |.|.  ....| ||.  |||..||.||.|||.| . 
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 628-724 4e-13 43.4 In-house 6-95 (95) alignment 
Range on Protein: 628-724
Range on HMM: 6-95/95.0
PVNEFAKHVASLHADGDIGFSREYEAIQnecISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHptpgQKKNLDYINANFIDGYQKGHAFIGTQG
 |  |  ||  .|.. |  |  |. .|.   ..   |        |  |||.|||  || .|| |      |.. ||||| |.||| .  ..| .||
hvsvfhshvlemhsnsdqefdnefksis...mtsgapytvgsseanipknrflnifpydatrvvlt....tkrdsdyinacfvdgyarkncyiaaqg
0040438 (Phosphotyrosine protein) phosphatases II 629-918 1.4e-97 322.0 In-house 2-281 (317) alignment 
Range on Protein: 629-918
Range on HMM: 2-281/317.0
VNEFAKHVASLHADGDIGFSREYEAIQNECISddlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqKKNLDYINANFIDGYQKGHAFIGTQGPLPD
|... ...  |.. .  ....|.| ...  ..   .......|||| |||| .|  ||||||.|.|..|   ..|||||...||......|| ||||||.
vldlllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpn

TFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLklkkkkQCNTEKLVYQYHYTNWPDHGTPDHP
|.. ||||.|||.| .|||.|.|.|.||.||. ||| ... ||| ..|.|..||... .|.|||....|      .....  |...|||.|||||.|..|
tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl......gdsesrtvthfhytgWpdhgvppsp

LPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGET
 ..|.|...  .|.. . ||..||||||||||||.|... || |..... |.|.  ....|.||.  |||.|||.||.||| | .  ..|
dllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 629-924 1.5e-68 226.3 In-house 4-290 (439) alignment 
Range on Protein: 629-924
Range on HMM: 4-290/439.0
VNEFAKHVASLHADGDIGFSREYEAIQneCISDDLPCEHS--QHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNlDYINANFIDGYQKGHAFIGTQGPL
 .|| .||  |. . .  |. ..| |.  ..| |  |. |   .  .. |||| ...|.||.|| |. .||  .   |||||.|.|| . . .| |||| 
rdefqehvekldknkqeifkeifekin..stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphs.hyinanyikGyyddklyiatqgpk

PDTFDCFWRMIWEQRVAIIVMITNLVERGRrkcdmYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIkhlkLKKKKQCNTEKLVYQYHYTNWPDHGTPD
 .| |.|||...|.... |||.|||||  .     ||| |.   || | |.   .  .  |..| ...    .... ... |. | |.||. |||.  | 
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkv....fnerdttekertvlqfhyiawpdknvpa

HPLPVLNFVKKS-SAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQ
.   ||.|..   || .  | ||.||||||||||||| | ||  |.|.. .| |.. | .. .| ||. .||.  ||.|...|..| |  |.. .. ..
qashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtide
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 630-911 2.7e-44 146.0 In-house 12-281 (290) alignment 
Range on Protein: 630-911
Range on HMM: 12-281/290.0
NEFAKHVASLHADGDIGFSREYEAIQNECISdDLPCEHSQHPENK--RKNRYLNITAYDHSRVHLHPtpGqkKNLDYINANFIDGYQKghAFIGTQGPLP
. | |  ..    .  ....||       .    . | .   .|   .|||| ...  | .|| |.   |   . ||. ||...| .    || |||.| 
eafekfasdvvkknvdelakeyleklkpylp.vqylerkifdkntefkknrykdvvcndktrvilkd..G..ydGdyvhanyvkGlka..mfiltqGalk

DTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDG--VETYGVIQVKLIEEEVMSTYTvrtlQIKHLKLKKKKQCNTEKLvYQYHYTNWPDHGTP
||   .|||. ...|| |||. .|.| |. ||. |.|.    | |.| | |   ||.   . .    . | | ...|..    || . ..   |||.  .
dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdani....ikktlsvrdkdsGkehkl.khlkikswpdksva

DHPLPVLNFVKKSSAAnpaeAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
   | .|  ..    |    .||.|||||||.|||||.. ... |. . .   ... .  | .|  |   || . ||. | ..|..
lstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 631-914 5.6e-59 194.3 In-house 4-294 (301) alignment 
Range on Protein: 631-914
Range on HMM: 4-294/301.0
EFAKHVASLHADGdigFSREYEAIQNEcisDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPG-QKKNLDYINANFIDGYQKGHAFIGTQGPLPDT
.  .|||. |...   |. .|......   .| .|. . . |||. ||. ||| ||. |. |.|.|  .... .||||..||||.. ..|| .|||.  |
dlgthvaakhsnk...feeqykelkeg...edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkkt

FDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD--GVETYGVIQVKLIEEEVMSTYTVRTLQIKHL------KLKKKKQCN---TEKLVYQYHYTN
   |||.||..... |||.||| |. . ||  |||.     |..| ..|.|..| |.  ...| |..|        ....| . .   . . | |.. |.
lvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtd

WPDHGTPDHPLPVLNFVKKS-SAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
||..|    |  ||. . .   . .  . ||.|||||..|.|.|.|. ..  | | .   .|.||.  . .| ..   |.| |||....|.. . ..
WpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 633-913 6e-90 296.2 In-house 9-279 (288) alignment 
Range on Protein: 633-913
Range on HMM: 9-279/288.0
AKHVASLHADGDIGFSREYEAIqnECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNlDYINANFIDGYQKGHAFIGTQGPLPDTFDC
 ..||  .|..  |||.||...    .  .   . .....|..|||| || .||. ||.|.  . .... |||||..|||..| ...| |||||.|| . 
vakvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeaga.DYinasyidgekkkkkyiatqgPladtvnd

FWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGV-ETYGVIQVKLIEEEVMSTYTVRTLQIKhlklkkkkQCNTEKLVYQYHYTNWPDHGTPDHPLPV
||....|...  |||.|.|||.|..||. |||...  . || ..|.|.|.. .  ...|.| ..        . .||  . ||.|. ||||| |.   |.
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle........kkkteleitqyqylaWpdhgvPeskapl

LNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
|.....   ||.|..|||.||||||||||||.|.|||......... ..|.|.. ..| ||..||||..||.|....|.. |
lellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 633-914 4.1e-85 280.3 In-house 3-277 (281) alignment 
Range on Protein: 633-914
Range on HMM: 3-277/281.0
AKHVASLHADGDIGFSREYEAIQNecISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDC
 ||...|... . || .|||....  |  | . . |...||. |||| ||.|||..||...|.  ..|| |||||||..||.. ...| ||||.|.... 
rkhlkqlsqndnaGfieeyeklaa..igvdntataskadenvlknrYsnivaYDatrvkvtpne.enkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDG-VETYGVIQVKLIEEEVMSTYTVRTLQIkhlklkKKKQCNTeKLVYQYHYTNWPDHGTPDHPLPV
||.|.|||.| .|||.|. .| |. ||  ||| |    .|| ..|| ..||  .||  |....      ......| . | | .||.||||| |. .  .
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl......eresget.reveqlaytaWPdhGvPattkel

LNFVKKS-SAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQ-QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
|.| |.  .. .. .  |.|.||||||||||||| || ..|... ... ..|   ....| .||..|||  || |.. |...|. 
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 636-912 5.4e-82 270.2 In-house 7-289 (297) alignment 
Range on Protein: 636-912
Range on HMM: 7-289/297.0
VASLHADGDIGFSREYEAIQNECISDDLpcEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKnLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWR
|| ... |  | |.||..|.|| ..  .  ..|... | .|||| ..  ||..||.|  ......  |||||||.|||.. .|||.|||||. |.. |||
vayvkekgkrGlskeyaeirnepveGtf..lasklranleknrytdvlcydetrvvlakvdedea.sdyinanfvdGykqkkafiatqGplkktvsdfWr

MIWEQRVAIIVMITNLVERGRRKCDMYWP--KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQcnteklVYQYHYTNWPDHGTPDHPLPVLN
|.|||.| .|||.| .|||||.||  |||  .. .. .| ..|. .| |... |.||.|.||. | .....      |  . .. |||.|.|.    .|.
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrk......vthfqflsWPdyGvPssaaslld

FVKKSS-------------AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEA
...|                . ...  |||||||||.|||||.| ||  |....... |.|.  ....|.|| | .||.||| | . |..| 
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN23_pd Subfamily PTPN23 639-913 7.5e-58 190.6 In-house 9-280 (288) alignment 
Range on Protein: 639-913
Range on HMM: 9-280/288.0
LHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHptpgqKKNLDYINANFIDGYQKG-HAFIGTQGPLPDTFDCFWRMI
   ||  .. .... ....   .      .    .  |||. .|  |||.||.|.     ... ||||| |. .   |   || ||.||. |   ||.|.
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEQRVAIIVMITNLVERGRRKCDMYWPKDG--VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEklvyqyHYTNWPDHGTPDHPLPVLNFV
.||.. .|||...  |.|. |.| |||.|    ...| ..| | ... ..|.  |.|....|. ...|.          ..|.||..| |. |  .|.|.
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshl......qltsWpelGvPasPetllqfl

KKSSA----ANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKN-IVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
..  .     .     |.||||||||||||.. .. | .......| ....   ....|.|| | ||..||. |. .| .||.
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0036941 (Phosphotyrosine protein) phosphatases II 640-920 8.9e-95 312.7 In-house 8-284 (297) alignment 
Range on Protein: 640-920
Range on HMM: 8-284/297.0
HADGDIGFSREYEAIQNECIsdDLPCEHSQHPENKRKNRYLNITAYDHSRVHLhptpgQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWE
....  ....|.| ...  .  . ...... |||. |||| .| .|||.||.|     .. . |||||...|||. ...|| ||||||.|.. ||||.||
kllflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

QRVAIIVMITNLVERGRRKCDMYWPKD--GVETYGVIQVKLIEEEV--MSTYTVRTLQIKHLklkkkkQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFV
|.| .|||.|.|||.|| ||. ||| .  .. ||| ..|.|...||   ..||.|||.....      ... .. |...|||.|||||.|..| ..|.|.
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt......gngesrtvthfhytgwpdhgvpespaslldfi

KKSSAANPA--EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQ---QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL
..   ....  . ||..|||||||||.||.|..| || |..     . |... .....| ||.. |||.|||.||..|| | . ...| .
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0047943 (Phosphotyrosine protein) phosphatases II 641-913 8.8e-95 312.5 In-house 8-272 (273) alignment 
Range on Protein: 641-913
Range on HMM: 8-272/273.0
ADGDIGFSREYEAIQNECIsdDLPCEHSQHPENKRKNRYLNITAYDHSRVHLhptpgQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQ
..|  .. .|.|.... ..  .|.......|||| |||| .| .||||||.|     . .. |||||...|||.....|| ||||||.|.. ||||.|||
llgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RVAIIVMITNLVERGRRKCDMYWPKDG---VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKlkkkkqCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK
.| .|||.|.|||.||.||. ||| .|   ..||| ..|.|..||. ..||||||....|.      .. .. |...|||.|||||.|... ..|.|...
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg......tgesrtvthfhytgwpdhgvppslesllefiel

SSAANPA--EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
   |. |  . ||.|||||||||||||.|.|| .| |.. .. |.|.  ....| ||   |||.|||.||..||.| .
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 643-915 6.1e-83 273.3 In-house 24-299 (306) alignment 
Range on Protein: 643-915
Range on HMM: 24-299/306.0
GDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHptPGQKKNLDYINANFIDGYQKG--HAFIGTQGPLPDTFDCFWRMIWEQ
.  ||. |.|..|.|  .. |  .....||||.|||| ||  .||.|| |.    . .. ||||||.|.. .||  ...| ||| |..|   ||||.|..
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

RVAIIVMITNLVERGRRKCDMYWPKDGV-ETYGVIQVKLIEEEVMSTYTVRTLQIKHLklkkkKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK--
   .|||.|. ||||. ||  |||.    |.||.|.|. ..|. ...|..|.|....      |. ..|. |.|||...|||||.| .|  ||.|...  
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.....kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

--SSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS
  ..  . |||||||||||||.|||||.||.|..||.|..| .   ...  . . .|.||. |||||.|| |.. |. . | .
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 643-912 2.6e-47 156.1 In-house 4-258 (267) alignment 
Range on Protein: 643-912
Range on HMM: 4-258/267.0
GDIGFSREYEAIQNecISDD-LPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQkknldYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQR
 .  . .|.| |..  |||.   .  |   .|. .||. .   ||..|| |  .  .     |||| ...||....||| ||.||  |   |. .| .|.
eeceiekefelikk..isdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdqk

VAIIVMITNLVERgrrKCDMYWPKD--GVETYGVIQVKLIEEEVMSTYTVRTLQikhlkLKKKKQCNTEklVYQYHYTNWPDhGTPDHP--LPVLNFVKK
|..||..|.  .    .  ..||      . |  . |.   |.    | . ||.     || |...  .  |  |.| .|    | ..|   |..  . |
vpvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitle.....lkfknesahn..vtlyyykkwni.ntnnkpylkplfgilak

SSAANpaEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEA
    |     |.||.||.||||.||..|.|..|..... .....| |||.|| ||  ||.| |.||..|. |.| 
nqlen..gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0046845 (Phosphotyrosine protein) phosphatases II 646-916 2.2e-97 321.1 In-house 1-277 (284) alignment 
Range on Protein: 646-916
Range on HMM: 1-277/284.0
GFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGY-----QKGHAFIGTQGPLPDTFDCFWRMIWEQ
|. .|.|....  ..  |.......|||. |||| .| .||||||.|....|. .. |||||...|||      . ..|| ||||||.|.. ||||.|||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RVAIIVMITNLVERGRRKCDMYWPKDG-VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLkkkkqCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSS
.| .|||.|.|||.|| ||. ||| .| | ||| ..|.|..|||...||||||....|..     .. .. |...|||.|||||.|..| ..|.|...  
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.....tgesrtvthfhytswpdhgvppspedlleflrlvr

AANP--AEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKN---IVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG
 ...     ||||||||||||||||.|.|| .|.|.....    |.|.. ....| ||.. |||.|||.|...||.|.. ..
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPN12_pd Subfamily PTPN12 646-915 2.6e-80 264.4 In-house 9-279 (290) alignment 
Range on Protein: 646-915
Range on HMM: 9-279/290.0
GFSREYEAIQNEC----ISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKkNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQR
 |..|.......      ..  . |.....||..|||| .|  ||.|||.|. . ... . |||||||| | .. ...| .|||||.| | |||||||..
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

VAIIVMITNLVERGRRKCDMYWPKDGVET--YGVIQVKLIEEEVMS-TYTVRTLQIKHLklkkkkqcNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKS
| |.||. ..|| |. ||. |||. | |.  .| ..|.|.||. ..  ...|||....         .... |||.|||.|||||.|  . ..|..... 
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielv

SAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS
   . .|. |.||||||||||||| |..| . .......|   ..||  ....| ||. ||||.||| ... |..| . .
relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 646-916 6.8e-65 214.0 In-house 20-280 (315) alignment 
Range on Protein: 646-916
Range on HMM: 20-280/315.0
GFSREYEAIQNECISddlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTpGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAII
 ||.|.  . .  |.   .   .....| .|||| ||  .|..|| |     .. . ||||| .| .... .|.| .||||. . | ||||.....|. |
lfseefhdlpdPdiy...rqrvaretinfkknryknilPldsarvklevi.ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMITNLVERGRRKCDMYWPK--DGVETYGVIQVKLIEEEVMSTYTVRTLQIkhlklkkkKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANP
||.|.. |  . ||  |||.       .| |.|.|.. |  .  ..| | .        .. .. . | |...|.|||.|.. .   .|...|.  | | 
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvt........rkseesrtvtqfqftewPdkGvdkqtssllklikevkadng

AEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG
 .  ...|||||||||||  | .| ...||.... |.|| |.. .||.| .||||||.| |..||. | .   
kkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 646-915 8e-53 174.2 In-house 21-238 (392) alignment 
Range on Protein: 646-915
Range on HMM: 21-238/392.0
GFSREYEAIQNECISddlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAII
 |. |.  . .  |.   |   .|.. |..|||| ||  || .||.|     .  . ||.|| .|....  .|.| .||| . ..| ||||.....|. |
lffeefhdlpgpdiy...pqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtti

VMITNLVERGrrkcdmywpkdgvetygviqvklieeevmstytvrtlqikhlklkkkkQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAE
.|.|.| |                                                  . .  . | |.|.|.|||.. | |   .|.|.|. .|     
amvtklkegd................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

AGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS
. |...||||||||||  | .|... . ..  .|.|| |.  || .| ..|||.||| |.. |..| .  
thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_egg_pd Subfamily egg 646-909 1.3e-30 101.2 In-house 15-266 (307) alignment 
Range on Protein: 646-909
Range on HMM: 15-266/307.0
GFSREYEaIQNEcISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNlDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAII
.. | .| . .|  .|. . ...   .|. | |   .   | |||.|.   ||  . |.| || ..|      || .| || .| | ||||.....|  |
elerrle.vlee.svdeislttaasdnnlekarskrvhckdssrvklelrrGqyld.dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMITNLVERgrRKCDMYWPKDGVETYGVIQVKLI-EEEVMSTYTVRTLQIKHLKLkkkKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAanpa
||.|  .|    .|. ||||   ..  ..   |  |   .   .   ... .|||      . |..  ..   ..   .    || ||  ... |     
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgdvnnssdvysplrvlrklrnlsk....

eagPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIV--NVFGFLRHIRAQRNFLVQTEEQYIFLHDAL
   |.||..  || ...| . ..  | .. .  |.   |      .| .|.. |..  .|.|..  .
...pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
DSPc_SM00195 647-913 8.9e-92 302.5 In-house 2-262 (263) alignment 
Range on Protein: 647-913
Range on HMM: 2-262/263.0
FSREYEAIQNECISDdlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQkKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
...|.| ....  ..  .........||.|||| ||  |||.||.|...... .. ||||||.|.|..| ...| ||||||.|.. ||||.||..| |||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MITNLVERGRRKCDMYWPKD--GVETYGVIQVKLIEEEVMS-TYTVRTLQIKHLKLkkkkqcNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANP
|.|. .|.|..||| |||..  | ||.| |.|||.|.| ..  ...|||.... .       .... |.||.|.||||||.||.. .||.....    . 
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkksks

AEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
 . ||||||||||||||||....| .|....... |..|  ....| ||  .|||.|||.|...|..|.|
tssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 647-913 8.9e-92 302.5 In-house 2-262 (263) alignment 
Range on Protein: 647-913
Range on HMM: 2-262/263.0
FSREYEAIQNECISDdlPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQkKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
...|.| ....  ..  .........||.|||| ||  |||.||.|...... .. ||||||.|.|..| ...| ||||||.|.. ||||.||..| |||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MITNLVERGRRKCDMYWPKD--GVETYGVIQVKLIEEEVMS-TYTVRTLQIKHLKLkkkkqcNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANP
|.|. .|.|..||| |||..  | ||.| |.|||.|.| ..  ...|||.... .       .... |.||.|.||||||.||.. .||.....    . 
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkksks

AEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
 . ||||||||||||||||....| .|....... |..|  ....| ||  .|||.|||.|...|..|.|
tssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 647-911 1.3e-37 124.0 In-house 13-267 (281) alignment 
Range on Protein: 647-911
Range on HMM: 13-267/281.0
FSREYEAIQNECISDdLpCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
| .|.  .  .  || | |   ..| |..||||||| . | |||.|.    .|.  ||| ||.|      . .| ||||  .|   ||||||..  . ||
fkqefsnlpgdppsd.l.ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MITNLVERGRRKCDMYWPKDgveTYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKkqCNTeKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAanpaEA
|. ...|  | ||  |.|..   .. ..|.  .  .   .   ..|   .|.|  .   .| .|. .. . .|||   |.    .|. ..|  |     .
mlcqfletnrekcaeyfprn...ahcclqfdklsvsyedstvnkslvttrlnlsye..get.rlithwlwkewpdwqvpessevmlkilrkira....rs

GPIVVHCSAGVGRTGTYIVLDAMLKQIQQKN-IVNVFGFLRHIRA-QRNFLVQTEEQYIFLHDALVE
 | |.||||||||.|| . ..  |. |. .  . ..   . |.|   |   ||| .||...   |..
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 647-921 2.3e-30 100.4 In-house 21-284 (312) alignment 
Range on Protein: 647-921
Range on HMM: 21-284/312.0
FSREYEAIQNecISDDLPCehSQHPENKRKNRYLNITAYDHSRVHLHptpGqKKNLdYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
...|| |. |  |  |  |  .     |  ||| ||  .|  |  |    |  .|. || |||.    |   |. ||||| .|   ||..      . |.
ltkeykavgn..ivsdsec..taflkfkdlnrypniqcwdrgrftla...g.denf.yihanfvkictkperfvctqgplentcthfwqlalslgstsii

MITNLVERGRRKCDMYWPkDG-----VETYGVIQVKLIEEEVMSTyTVRTLQIKHLKLKKKKQCNTEKLvYQYHYTNWPDHGTPDHPLPVLNFVkkssAA
... .|| |  ||  |   |      .| . |      | |.    .   .  . ||.  |   .  ||  .| .. ||||| ||     | ..    .|
llcgfvedgsekcakyis.divgfvdledhrvyteycteieiggk.skdkithrvlkvvvkatgqeskl.nhyqwaswpdhgmpdscdtalrll....sa

NPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQI---QQKNIVNVFGFLRHIRAQRnflVQTEEQYIFLHDALVEAIASGETNLM
   .  |.. ||||||||||| .....|.  .   ...|. ..| .||. ||.    |..  ||..   ...| . |      
vkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars...vrvfpqyvyalrcvleflyskglykr
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 647-910 2.6e-18 60.5 In-house 28-282 (302) alignment 
Range on Protein: 647-910
Range on HMM: 28-282/302.0
FSREYEAIQNECISDDLpCEHSQhpENKRKNRYLNITAYDHSRVHLhptpgQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTF---DCFWRMIWEQRVA
  .|...|..  .. .  |.  .  .| .||.  .. ..|. .| |     .... .|.||  ..  . ..  | .| |  |.    . ||||.......
vkkefkkidtmkvdlek.Ckafk..knlkknqsedvpildsnlvkl.....eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IIVMITNLVERGRrKCDMYWP--KDGVETYGVIQVKLIEEEVMSTYTvRTLQIKHLklkkKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAA
 .|..    |  .   . ..|   .  ..|| . |     | ..  .   . |  |     . |    |.  |. |||...  |..   . . ..|  | 
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvl....PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfak

NPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALV
.     ..|.    |.|| |. ..| . ....|... .|.   .. ||.||   |.. .||..|. ||.
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_PTPRN_pd Subfamily PTPRN 648-913 2.6e-61 201.9 In-house 32-292 (297) alignment 
Range on Protein: 648-913
Range on HMM: 32-292/297.0
SREYEAIQNeCISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqKKNLDYINANFI-DGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
..|.||. .   ...  .| .....| .|||. .. .||||||.|. .   ... ||||| .| |   .  |.| |||||..|   ||.|.||| |..||
ekewealca.yeaepstkevakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMS-TYTVRTLQIKHLKlkkkkqCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAE
..|.| | | ..|. |||..| |.|.. .|.|. | . .  | ||.. .| |.       .  . | |.|.  ||..|.|  . ..|.| .|   .    
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq......tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

AGPIVVHCSAGVGRTGTYIVLDAMLKQIQQ-KNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
. |||||||.|.||||.||..| .|.....  . ...   | |.| ||. ||.|..|. |   |..| .
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 648-911 8.4e-53 174.0 In-house 13-275 (287) alignment 
Range on Protein: 648-911
Range on HMM: 13-275/287.0
SREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPgqKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVM
 .|..|....  |  .    ...  . .|||| ..  .|..|| |  ..  ..  ||||||.. .|.. .||| .|||.. |   |||...|.|.| ...
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg..elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

ITNLVERGRRKCDMYWPKDGVE-TYGVIQVKLIEEEVM-STYTVRTLQIKHLKlkkkkqCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKS-----SA
.|  || .| ||  |||.  |    |   | |.. ...   |.||.|.. .|.       .  ..| |... .|||.. .   . .. || .       |
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle......trearvvkqldllswPdkvlaPtavglirfvldvkqhiela

ANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
 . .|.||.|||...|.||.|... . ..... ..   |.|   . ..| .|. |||.  |. .| .||| 
rdasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 649-919 6.2e-79 260.6 In-house 38-297 (319) alignment 
Range on Protein: 649-919
Range on HMM: 38-297/319.0
REYEAIQNECISdDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKnLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMI
 |. .. .  ..     ...  ..|| |||. || |.|...| |... |.    ||||| |..|||.   .| .||||..| . |||||||.... ||..
vefrracklgvn.ladqtfanldqnkdknriinilafdknvvklerliGeef.sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TnlvergRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAA--NPAEA
|      . ||  |||...|....  .||.   |  . |.|| ... .     . . .  . . |.|.  |||.| ||.| ... .||| .       . 
t......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielse.....dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETN
 .|||||||||||||.|||||..|....... |.|. |.| .| ||| |||   || |.. ||.|    | ..
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_PTPN1_pd Subfamily PTPN1 649-914 2.1e-68 225.2 In-house 6-272 (290) alignment 
Range on Protein: 649-914
Range on HMM: 6-272/290.0
REYEAIQNECI--SDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHptpgqKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
| |..| ...   ..|.|......|||. .||| ... |||||..|.     ... |||||....  .  . .| ||||||.| | ||.|.|||.   .|
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle.....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MITNLVERGRRKCDMYWPKDGV----ETY-GVIQVKLIEEEVMSTYTVRTLQIKHlklkkkKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK--SS
|. ..||... ||  |||..      .     ..||||.||. |.||||.|...       ....  . ....||| ||| | |. |   |.|. |  .|
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvres

AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
 .   . || |.|||||.||.||....|..| .|..|.    |..   | ..| .|  |.|| .|  | . |..| . 
GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_PTPN14_pd Subfamily PTPN14 649-914 2.7e-58 192.3 In-house 27-297 (300) alignment 
Range on Protein: 649-914
Range on HMM: 27-297/300.0
REYEAIQNECIsdDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTpgQKKNLDYINANFIDGYQ--KGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIV
 ||| |...    |  .. .. |||..|||. ..  |...||.| ||  .... .||||  |      | . .| .||||. |   ||.|.||| |..||
teyeripkkre..dallstaklpenaeknrfkdvlPyednrvelspt..kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MITNLVERGRRKCDMYWPKDG----VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKkkqcntEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKS----
|.|.  | |. |.  |.||..      ..|  .|     |  .... ..|..|||  |.      |. |.   ||.||||| |. . . |.....     
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske......ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr

---S-AANP-AEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
   .   ..  .  |..|||||||||||  |. | ... ... . ...   |...| || .||||  || |....|.. . 
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN13_pd Subfamily PTPN13 650-913 2.3e-66 218.9 In-house 16-269 (273) alignment 
Range on Protein: 650-913
Range on HMM: 16-269/273.0
EYEAIQNecISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqkknldYINANFIDG--YQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVM
|.. ...  .   . || ... |||.|||| |.  ||..||.|    |      ||||..|     .. . .| .|||||.| . ||.|.|||.. .|.|
efkelre..lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

ITNLVERGRRKCDMYWPKDG---VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQcnteklVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPa
.|. .|.|. ||. |||.     .  .. ..|.|.. . .....||.|..|... .. ..      | . ....|||||.| .....|.||..    .  
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesre......vahlnfvkwPdhgvPssaaellqfvaevrrlqt.

EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
.|||||||||||.||.||.|..|..|  |.... ..|   .|..| ||. .|||..|||| . |..|..
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 655-825 8.9e-13 42.4 In-house 78-236 (244) alignment 
Range on Protein: 655-825
Range on HMM: 78-236/244.0
QNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHptPGQKKNlDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVER
||    |    . .  |.|  |||      .| .|| |    |   |  |||| |.    .   .| || || ||   ||.|. |. | ..|..  . | 
qniirpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgn.tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee

grrkcDMYWPKD-GVETYgviqvkliEEEVMSTYTVRT--LQIKHLKLKKKKQCNT-EKLVYQYHYTNWPDHGTP
     | |||    .| |        ||..  | | |    .||  .|. . . |   . .  .  .|||  || 
.....deywpdseplewy........eeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
0045098 (Phosphotyrosine protein) phosphatases II 659-913 1.4e-85 282.3 In-house 19-272 (278) alignment 
Range on Protein: 659-913
Range on HMM: 19-272/278.0
ISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHlhptpgqkknlDYINANFIDGYqkGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRK
 ..   ..... ..|. |||| .| .||||||.           |||||..||||  ...|| ||||||.|.. ||||.||... .|||.|.|||.|| |
lgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCntEKLVYQYHYTNWPDHGTPDHP--LPVLNFVKKSSAANPA------------
|..||| .|..||| ..|.|..|||...||.||| . .| ....  .  .  |...||..|||||.|..|   ..|....   .|. .            
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredle..srgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

-EAGPIVVHCSAGVGRTGTYIVLDAMLKQIqqKNIVNVFGFLRHIRAQRNF-LVQTEEQYIFLHDALVEAI
 . ||..||||||||||||..... ||...  .. |...  ....| ||..  ||..|||.||...|.| .
dsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 661-922 6.1e-57 187.7 In-house 21-275 (283) alignment 
Range on Protein: 661-922
Range on HMM: 21-275/283.0
DDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqkknlDYINANFID---GYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRR
 ||... .   |||||||. .| ..|  ||.|.. .      ||||| ||     |.... .| .|.|| .|   ||.|....... |||.|.| |  | 
pdldadiasadenkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

KCDMYWPKDGVETYGVIQVKLIEEEVMSTYTvrtlqIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGtPDHPLPVL-NFVKKSSAANPAEAGPIVVHCSAG
||  ||||.| | ||   | | .|    ...     || | |...  .... |.  | . .| . | .. ..  | .| |  |  .  . ||||||||.|
kCsqyWPkrGsedyGeftvtlrkettsnsfi.....ikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstg

VGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMA
.|||...| . | .|... . .|.||  .. .| ||  .||| .|| ..|.. .|    |.|.. |
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_PTPN3_pd Subfamily PTPN3 662-913 3.6e-69 227.8 In-house 30-275 (280) alignment 
Range on Protein: 662-913
Range on HMM: 30-275/280.0
DLPCEHSQHPENKRKNRYLNITAYDHSRVHLHptpgQKKNlDYINANFIDGYQKG----HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRR
.| ..... |||  |||| .|..||. ||.|.    . .. ||||||...    .      .| |||||..|   ||.|.|||.. .|||.|.|||||| 
glaisaarkpenlsknryrdilpydatrvklk....eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCDMYWPKDG-VETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkkKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAG
||  |||. .   .|| ..||. .|.  ..| .| | .|.      |. . |. . |  |..||||| ||..  .|.||..  ..  ..  |.|||||||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkd......ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaG

VGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
.|||| .|.|.  |  |.... |..   .|..| ||  ||||..|| |. .|.... 
igrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
0049772 (Phosphotyrosine protein) phosphatases II 662-913 1.6e-45 151.6 In-house 35-280 (314) alignment 
Range on Protein: 662-913
Range on HMM: 35-280/314.0
DLPCEHSQHPENKRKNRYLNITAYDhSRVHLHPTPGQKknLDYINANFIDGYqkgHAFIGTQGPLPDTFDCF----------WRMI--WEQRVAIIVM--
.| .  .....|. |||||.|  .| .||.|.  |..    |||||...||.    .|| |||||. |...|          |||.  ....| .|||  
eltilvadlflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------ITNLVERGrrkcdmywP----KDGVETYgviqvklieeevmstyT-------VrtlqikhlklkkkkqcntEKLVYQYHYT
                   ...| ..|        .    .|  .                  .       .                  |.|...|...
devladelsrLdaAlgKtpllildgng........neptaadlellk................eelydpelf..................erlgikylri

NWPDHGTP--DHPLPVLNFVKKSsaanpAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQqkniVNVFGFLRHIRAQRN-----FLVQTEEQYIFLHDALV
..||...|  .. . .|.|...       . ||..|||.||.|||||..|.. ..|. .    |..   |...|..|       .... |||.| ..|| 
pvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefileall

EAI
|..
eyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 663-911 2.3e-73 241.7 In-house 14-266 (274) alignment 
Range on Protein: 663-911
Range on HMM: 14-266/274.0
LPCEH----SQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQK-GHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRR
|| ..     . . ...|||| .|   ..||| |..  .......|||||.| ||..  .|.. |||||| | . |||||....| .|||.|.| |. ..
lPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

KCDMYWPKDG-V---ETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKkqcnteklVYQYHYTNWPDHGTPDHPLPVLNFVKK---SSAANPAEAGPIV
|| .|.|..  .   |.|| ...|  .      |.||.| .|.|. ...        |. | ||.|||| .||.. ..|..|..   |  .. |...|.|
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers........vkhywytdWPdhksPddantlldlvleveesreeenaklapvv

VHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
||||||.|||| .|  .  ..|......|.|..   ..| .|  .|||.||| ..| ||..
vhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 663-914 9.1e-19 62.2 In-house 35-280 (303) alignment 
Range on Protein: 663-914
Range on HMM: 35-280/303.0
LPCEHS--QHPENKRKNRYLNITAYDHSRVHLHptpgqkkNLDYINANFIDGYQKGHAfIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCD
|| . |  |  .|  |||. ..   |||.|.|        .  || |....   . .| | || ||. |   ||.|| ||.|  ....    |  .   |
lppsvsknqfvknmdknrfvdvicldhskvkls.......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggd

MYWPKDGveTYGVIQVKLIeeEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDH--PLPVLNFVK-KSSAANPAEAGPIVVHCSAGV
. .|..    .  .. . |   |     |   .   ||.    . .   ... .|| .||    | .  |  | .  . .|   . ... | |    .|.
svfprnq..dflkfeersi..rvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgc

GRTGTYIVLD-AMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
||.||. ... | |   .... ...   |  .|  |   ||   |. ...  | | . 
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 663-712 9e-09 29.1 In-house 37-85 (440) alignment 
Range on Protein: 663-712
Range on HMM: 37-85/440.0
LPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNlDYINANFIDG
 |.. .  |.|| |||| || ||||||| |.   |  .. ||||| .|.|
qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpds.dyinasying
0040439 (Phosphotyrosine protein) phosphatases II 664-913 4.7e-84 277.1 In-house 2-246 (249) alignment 
Range on Protein: 664-913
Range on HMM: 2-246/249.0
PCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYW
.......|||| |||| .| .||||||.|...||     |||||..||||. ...|| ||||||.|.. ||||.||... .|||.|.|||.|| ||. ||
eysvallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLklkkkkQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPA--EAGPIVVHCSAGVGRTG
| .|. .|| ..|.|...||.. ||||||....|      .....  |....||.|||||.|... ..|.|...   |. .  . ||..|||||||||||
plggsleygdftvtllsvevkddytvrtleltnl......ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
|.|... || |.. .. |...  ....| ||.  ||..|||.||..|| | .
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 664-914 3.9e-64 211.6 In-house 34-277 (515) alignment 
Range on Protein: 664-914
Range on HMM: 34-277/515.0
PCEHSQHPENKRKNRYLNITAYDHSRVHLHPTpGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYW
|   .|   | .|||| ||  || .|| |     .. . ||.|| .| ...  .|.| .|||.. . | |||......|. |.|.|.| |  . ||  ||
pqtvaqeeinfkknryknilPydsvrvklevi.ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PK---DGVeTYGVIQVKLIEEEVMSTYTVRTLQIkhlklKKKKQCNTeklVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRT
|.   | |  .| |.|.|.  |  .  . |.|..      | ....|   | |.|.|.|||.|.| |   .| ..|.  | .   . |...|||||||||
Pdkpgdsv.kfGsikvelvsleactggikrkltv.....lkgddsrt...vtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrt

GTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
| .| .| .. .... ..|.|| |.. ||..| .||||.||| |...|. | . 
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_CG7180_pd Subfamily CG7180 664-915 5.6e-58 190.9 In-house 33-292 (296) alignment 
Range on Protein: 664-915
Range on HMM: 33-292/296.0
PCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLdYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRrKCDMYW
 | .  . ||. |||. ..  ||. || |.   |..|.  |||| ..|.. | ...| |..|  .| | |||..... .  .|..|.  .  . ..  ||
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHL---KLKKKKQCN-TEKLVYQYHYTNWPD-HGTPDHPLPVLNFVK---KSSAAN--PAEAGPIVVHC
|... | || | |...||. ..  . ||.....      ...|| .  ...| ....| |.  .  |     ......   .    .    | ||.||..
pnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS
| |..|.| |. .|| | ...... |.||.... .| .|. ||.. |.| .. | | ||.  
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
0042113 (Phosphotyrosine protein) phosphatases II 665-911 2.2e-82 271.4 In-house 1-241 (245) alignment 
Range on Protein: 665-911
Range on HMM: 1-241/245.0
CEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGqKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP
......|||| |||| .| .|||.||.| |..|    .|||||...|||.  . || ||||||.|.. ||||.||... .|||.|...|.|| ||. |||
ysvallpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLklkkkkQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANP-AEAGPIVVHCSAGVGRTGTY
 ... ||| ..|.|..||....||||||....|      ... .. |..|||..|||||.||..  .|.|..    |    . ||..||||||||||||.
lgesltygdftvtllseehlddytvrtlevtnl......gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf

IVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
|... || |..    |...  ....| ||   |||..||.||..|| |
iaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 665-911 3.3e-77 254.6 In-house 2-240 (243) alignment 
Range on Protein: 665-911
Range on HMM: 2-240/243.0
CEHSQHPENKRKNRYLNITAYDHSRVHLhptpgqkKNLDYINANFIDGYQKghaFIGTQGPLPDTFDC----FWRMIWEQRVAIIVMITNLVERGRRKCD
. ....|||. |||| .| .||||||.|       .. ||||||.|... .   .| ||||||.|..     ||||.||... .|||.|.|||.|| ||.
fsiallpenlsknrysdilpydhsrvkl.......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

MYWPkDGVeTYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKqcnteKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAA--------NPAEAGPIVVH
.||| ..| ||| ..|.|..||... ||||||....|.|.. .     .||..|||..|||||.||.| ..|.|...  .         .  . ||..||
qywp.gev.tygdftvtllseehlddytvrtlllenldlddlt.....rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSAGVGRTGTYIVLDAMLKQIqqkNiVNVFGFLRHIRAQRNF-LVQTEEQYIFLHDALVE
||||||||||.|... ||...   . |...  ....|.||..  |||..||.||..|| |
CsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 665-913 5.3e-35 115.7 In-house 27-270 (285) alignment 
Range on Protein: 665-913
Range on HMM: 27-270/285.0
CEHSQHPENKRKNRYLNITAYDHSRVHLhptpgQKKNLDYINANFIDGYQKG-HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYW
| .. .  |   ||| .. . . .|| |     .... ||| |...    |   ..| ||||||.|.  ||.||.....| ..|.  |.| |  || .|.
ctytayeanpdlnryadvrcieetrvvl.....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PKDG--VETYGVIQVKLIEeeVMSTYtVRTLQIKHLKLKKKKQCNTEKLVYQY-HYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAgPIVVHCSAGVGRT
|.    |  .|  .. | |  .     .    .. | . . .....| |  .. .   |||. .|.   |.... |     || |  ||.||||||||||
peklgevvkfgkyeitlte..ckeea.iagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrt

GTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI
 |.. .|    .| ..  ....  .| .|| |   ||.  |..||.  |.| .
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 666-920 1.2e-77 256.3 In-house 18-262 (284) alignment 
Range on Protein: 666-920
Range on HMM: 18-262/284.0
EHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKnLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITnlvergRRKCDMYWPK
...  ..|| |||. .| |.|...| |... |.    ||||| || |||. . .| |||||..| . |||||||.... ||..|      . ||  |||.
tfanldqnkdknrighilafdknvvklerliGeef.sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

DGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklkkKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAA--NPAEAGPIVVHCSAGVGRTGTY
..|....  .||.   |  . |.|| ... .     . . .  . . |.|.  |||.| ||.| ... .||| .       .  .|||||||||||||.|
kivikeerfkvkvdsveeseeyvvrdielse.....dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

IVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL
||||..|....... |.|. |.| .| ||| |||   || |.. ||.|    | ...
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 667-923 6.6e-37 121.7 In-house 46-298 (310) alignment 
Range on Protein: 667-923
Range on HMM: 46-298/310.0
HSQHPENKRKNRYLNITAYDHSRVHLHPtpGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD
.  . ..  |||| ..   | |||.|.    . .  ||| ||..       .|| .||||  |   |||||...|   |... . .| || ||  |||  
yeaykkymhknrysdvvcldtsrvklki..dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl

GV-ETYGVIQVKLIEEEvMSTYTVRTLQIKHLKL---KKKKQCNTEKL-VYQYHYTNWPDHGTPDHPLpvlNFVKKSSAANpAEAGPIVVHCSAGVGRTG
|| ||||.|.|  . |     . .  | .  .       .. .| ..| |   .. |||| | ||        | .   |.    || |||||||..|..
gvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc...htvpqrllaq.vrhgpcvvhcsagkdrly

TYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVeAIASGETNLmAE
. . |.  ...... . |..     ... .|   .||| ||....   . ..| |||.  ||
vvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetev.ae
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 667-827 1.6e-32 107.6 In-house 27-182 (297) alignment 
Range on Protein: 667-827
Range on HMM: 27-182/297.0
HSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKknlDYINANFIDGYQKGH--AFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP
 .. .   ||||| .| |.| .||.|  .. ..   |||||...   .. .   .| .|||| .| | ||....|| | .|||...| | || ||  |||
sakrnsslrknryrdilatddtrvkllrviter...dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

KDGVEtyGVIQVKLIEEEVMSTY-TVRTLQIKHLKLKKKkqcNTEKLVYQYHYTNWPDHGTPDH
.   |  .    ... | . ||     ....  |.|  .   . .. |    . .||||| |  
svvqe..rlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsd
subfamily_eak_pd Subfamily eak 668-918 1.6e-21 71.1 In-house 47-310 (332) alignment 
Range on Protein: 668-918
Range on HMM: 47-310/332.0
SQHPENKRKNrYLNITAYDHSRVHLhpTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDG
..  |. ..|  ..|  ||.  |.|  |. |. .| ||||  ..  . |. .| |  .  |    ||.|. ||.   ||.. . || .  | | |.|...
tarleavnrn.vvkivpydrylvrl..tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

--VETYGVIQVKL---IEEEVMSTYT--V----RTLQIKHLKLKKKKQCNTEKLV-YQYHYTNWPDHGTPDHPLPVLN----FVKKSSAANPAEAgPIvV
  .  .|...|.    ...... |    .     | ...| |.    . .. |.  .   .    . |..    .  .    ..||   . |. | || .
reelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfa.pi.i

HCSAGVGRTGTYIVLDAMLKQIQ--QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGET
 .. |  |.|...|.| ... |.  .||   |  ..  .. .|.  | .. |. |....... .   . 
qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 669-915 1.2e-83 275.1 In-house 5-244 (250) alignment 
Range on Protein: 669-915
Range on HMM: 5-244/250.0
QHPENKRKNRYLNITAYDHSRVHLHPTPGQkKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRkCDMYWPKDGV
..|.|| |||| .| |.|.||| |... |. |. ||||| |..||.. .||| |||||..|.  ||||..|. .. |||.|||.| ..  .  ||| .. 
kkpqnkeknryadiialdssrvvLekekgd.kesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ETYGVIQVKLIEEEVMSTYTVRTLQIKhlklkKKKQcNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPA-EAGPIVVHCSAGVGRTGTYIVLD
|.|| ..|.| ..|... ||.|.|..      |.|. . |..| |.|...||| | |..   ||...||  | ..  ...|..|.|||||||.|..|..|
ekyGdvtvsllskeefadytkrklkls.....kakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

AMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS
|.|........|.|| ... .|..|   |...|||.|.. .. .|. |
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 669-923 2e-64 212.6 In-house 47-294 (297) alignment 
Range on Protein: 669-923
Range on HMM: 47-294/297.0
QHPENKRKNRYLNITAYDHSRVHLHPTpGQKKNLDYINANFIDGYQKghAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRrKCDMYWPKDGV
..  |  |.|| ||  || |||.|. . ... . ||.|| |. |...   .| || | ..| . ||.|.....|..|||.... || . ||  ||...||
ekkvnfeksRYkniLPydssRvkLaiv.nddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

ETYGVIQVKLIEEEVMSTYTVRTLQIKhlklkkKKQCNTEKLVYQYHYTNWPDHGTPD--HPLPVLNFVKKSSAANPAEA-GPIVVHCSAGVGRTGTYIV
 |.| . |.|   .  . .  |.|...      | .  ....| ||....|||.  .   .   .|....        .| ||..|||.||||||| .. 
ttfGdvsvvllsvsereGfikrelevt......kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

LDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAE
.| .. ...... |..||.....| .| .||||.||| |.. |..||. | .|.. |.
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 669-928 5.6e-46 151.7 In-house 44-300 (305) alignment 
Range on Protein: 669-928
Range on HMM: 44-300/305.0
QHPENKRKNRYLNITAYDHSRVHLHPTpgqkKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGV
.. ... |||| ..   |. ||.|...       .|| ||..    . . || || || .|   || | ....|  | |. ||.|.| .||  |.. .  
keaqeagknrykdvgcldnnrvklegp....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

------ETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAAnpaeAGPIVVHCSAGVGRTGT
      |    |.||.   . ..  .    .... .|  .   .. . | .||. .||| | |   | .|....|. ..     ||||||||||.||||.
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgs

YIVLDAMLKQIQQKNIVN-VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAsgETNLMAEQVEEL
 ..|. .|.|. . .|..     |..|| |||  .||..||.|.|. ... .   . .|. |.|.| 
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr..kkklldeevkea
subfamily_ptpA1_pd Subfamily ptpA1 669-874 9.6e-42 138.2 In-house 43-257 (418) alignment 
Range on Protein: 669-874
Range on HMM: 43-257/418.0
QHPENKRKNRYLNITAYDHSRVHLHPTpGQKKNLDYINANFIDGYQkGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD-G
..  |  |||| ||   .|.||.|.    .|.  ||||||.|||    . || ||||||.|   ||||.||.|. ||||..   |  | ||| |||.. |
dkkhntsknrytnilpvnhtrvqlkki.qdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

VETYGVIQvklIEEEVMSTYTVRTLQIKHLK--------LKKKKQCNTeKLVYQYHYTNWPDHGTPDHPLPVLNFVKKS----SAANP--AEAGPIVVHC
 | . .       .||. ||.|  ... .          ..   . .| . . ||.|  ||||  |||  |. ....          |      ||.|||
geqfsiyg...ngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGVGRTGTYIVLDAMLKQIQ
|||||||||.     |.|...
sagvgrtgtfctavimmkkld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 670-914 7.2e-38 125.3 In-house 40-272 (288) alignment 
Range on Protein: 670-914
Range on HMM: 40-272/288.0
HPENKRKNRYLNITAYDHSRVHLHptpgqKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE
. .|  ..|| |.   | .||.|.          ||.|| .   .  . .| .| ||  | . .|.|. |. |  |||...|.|.|..| . |.|    |
fianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe

TYGVIQVKLIEEEVMsTYTVRTLQIKHlkLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSsaanPAEAGPIVVHCSAGVGRTGTYIVLDAM
.  . ..  .  .   .   .....    |. .|. .....| . |. .|.|.| |.  |. |....       .   |||||.||||||||| |.   .
karigrlctvvkkkr.adidklvkvsl..lriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililia

LKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA
|.... .. . .  .| . |..|   .||| ||...|  . | ..
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 671-911 1.5e-68 225.5 In-house 1-237 (237) alignment 
Range on Protein: 671-911
Range on HMM: 1-237/237.0
PENKRKNRYLNITAYDHSRVHLHptpGQKKNLDYINANFIDGYQK-GHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPK-DGV
.||| |||| ||.||||||| |.   |   . |||||....|..   . .| .||||  . | ||.|.|... ..|||.| |.|. . ||  |||. |  
senkiknrygnivaydhsrvvlk...gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

ETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKkkqcnTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPA--EAGPIVVHCSAGVGRTGTYIVL
..|||. | |  .| .| ||||.| . .   .|       .|..||..| |||.| |..   .| | |.    .|   |.|| ..|||||||||| ..|.
aaygvltvslkkkeefsdytvrslllskrltlk.....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

DAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
||||.| ..|..|... ..  |  .| ...||..||.|.|....|
damlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 671-912 1.4e-59 196.3 In-house 18-263 (270) alignment 
Range on Protein: 671-912
Range on HMM: 18-263/270.0
PENKRKNRYLNITAYDHSRVHLHPTpGQKKNLDYINANFIDGYQKGH-AFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKdgvE
  .|. ||| .|    ..|| |..   ....  |||||.. |... . ..| ..|||| |   |||||||..|  |||.|.|.|.||.||..|||.   |
argkklnRyadiLPsPatRvrleel.eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...e

TYGVIQVKLIEEEVMSTYTV--RTLQIKHLKLKkkKQCNTEKLVyQYHYTNWPDHGTPDHPL------PVLNFVKKS--SAANPAEAGPIVVHCSAGVGR
.   ....  . .|... ..  .   ...|.|.  .. ....||  ..|..||||| | ..        .|. ...   |  . ..|.|..|||||||||
pkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEA
||| |.|| ... ..... |.|   ....| .|  |||. ||| ||. |.|| 
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_CG42327_pd Subfamily CG42327 671-835 9.8e-29 95.0 In-house 26-187 (319) alignment 
Range on Protein: 671-835
Range on HMM: 26-187/319.0
PENKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINANFIDGYQKGHA-FIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPK----
.  | |.|..|.    ..|| |.  . ....  |..|... ||.. .. .|..| .| |.   |||..|||.  .|| .|.| | | ..|  |.|     
vtskdksrvinvvPlPetrvvlqrig.dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

DGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKlkkKKQCNTeklVYQYHYtNWPDHGTPDHPLPVLNFV
|. ..|| |.| | . ||   | . || .|...   |...     .  | | .|.. . | .. ...  .
dntslyGdilvtlkgrevkdryaistlllkrvd...keesre...lthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 671-763 7.9e-14 45.8 In-house 32-122 (332) alignment 
Range on Protein: 671-763
Range on HMM: 32-122/332.0
PENKRKNRYLNITAYDHSRVHLHPTPGQKknlDYINANFIDGYQKGHAFIGTQGPLPDTF-DCFWRMIWEQRVAIIVMITNLVERGRRKCDMYW
 .|   ||   . ..||||| | |  |.    |. ||...||| |  |.| .| |. |     ||||. |.. ..|... .. |. .||.    
lnnmdmnriphlycfdhsrvelapqdgkd...dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 671-749 2.6e-08 27.8 In-house 35-117 (347) alignment 
Range on Protein: 671-749
Range on HMM: 35-117/347.0
PENKRKNRYLNITAYDHSRVHLHPTPGQKKNLD----YINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMIT
  .  |||  .    | .|| | |   .. . |    ||||  |   .  . .| || |||||   ||.|.   .|. .| | 
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 672-911 1.4e-62 206.0 In-house 7-239 (239) alignment 
Range on Protein: 672-911
Range on HMM: 7-239/239.0
ENKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINANFIDGYQK-GHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPkDGVET
 || |||| || .|||||| |     .    |||||...  |.   .|.| ||| .  .   ||||.|..| ..|||.| |.|  ..||  ||| |    
vnkaknryanivtydhsrvvlekls.ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsk

YGVIQVKLIEEEVMSTYTVRTLQIKHLklkkkKQcNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAML
|  ..| | . ||.. | .||. . ..      |   |. |||||.| |||.| |..   || . .| .  .   | | |.||||||||||...|.||||
ycnlrvtlrktevfadyiirtfvmsqv.....gq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

KQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
.| .... |..| ... || .| ..||| |||.|.| |..|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 672-912 3.1e-44 146.2 In-house 40-276 (307) alignment 
Range on Protein: 672-912
Range on HMM: 40-276/307.0
ENKRKNRYLNITAYDHSRVHLHpTPGQkkNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGV--E
 |  |||| .. . |..|. .. ..|     ||| ||..    | . || .|||| .|   || |. ...|  ..|. ...| .. ||. ||| .     
antdknryqdvkcqdkgrivvk.fdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

TYG----VIQVKLIEEEVMSTYTvRTLQIKHLKLKKKKqcnTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKkssAANpAEAGPIVVHCSAGVGRTGTYIV
..|     | |. .  . ..      ...  ||..  .     . . .. ..||||.|.|.  |  .|...   | .  .  |.||||||||||.|| . 
vfgeapntisvanlgakklapde.dlinvttlkvdwaq...ksrtiqhlqwenwpdrgvpqinltainlle...avr.ydtnpvvvhcsaGvGrsGtiva

LDA-MLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEA
.   . | |. .|  ..  ... .|.||.. .||| ||..||  |.| 
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 672-910 6e-40 132.0 In-house 46-341 (350) alignment 
Range on Protein: 672-910
Range on HMM: 46-341/350.0
ENKRKNRYLNITAYDHSRVHLH----PTPGQK---KNLDYINANFIDGY----QKGHA--FIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRK
|   |||| ||  |.||||.|.    .. ..|   .  ||||||..       .      .| ||.||| |.| |...| .  | .|...|..|| ...|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CDMYWPKDGVETYGViQVKLIEEEVMST--YTVRTLQIKHLKL-----------KKKKQ------CNTE-KLVYQYHYTNWPDHGTPDHPLPVLNFVK--
|. ||.. ... . | ...   |..|..   . .. ..|.              |....        ..   ||| .. ||.| ..  .|  .|. ..  
cyrYWqegsydditv.klaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevk

-----K---SSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLK------QIQQKN---------IVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALV
     .    |  . |.. ||.||||||||||||.. || .|.      .....             ..  . ..| ||  .||. .|.||...|| 
ndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 672-881 1.2e-23 78.0 In-house 47-302 (349) alignment 
Range on Protein: 672-881
Range on HMM: 47-302/349.0
ENKRKNRYLNITAYDHSRVHLHPTPGQK-------------KNLDYINANFIDG--YQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGR
|   |||| .|  |.|||| |. ..                |  ||||||..    ..  . .| || ||| | | |...|  ..| ... ...  | . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

RKCDMYWPKDgveTYGVIQVKLIEEEVM---------STYTVRTL-----------QIKHLKLKKKKQCNTEK--LVYQYHYTNWPDHGTPDHPLPVLNF
.|||.|| .    .|  |.||| .               .||.             .  .  ...  . ..||   ..|  . ||.| ..   |  .|. 
ekcdiywqel...sysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqa

VK--K-----S---SAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLK--QIQQKNIVNV
..  .            . ..  ...|||||| ||||... || .|   .  |.. . .
levkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki
Y_phosphatase Protein-tyrosine phosphatase 673-911 2.9e-86 284.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 673-911
Range on HMM: 1-235/235.0
NKRKNRYLNITAYDHSRVHLhptPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP--KDGVET
||.|||| .|..||..||.|    |.... ||||||...||.. ..|| |||||..|.. ||||.|...| .|||.|.|.|.||.||. |||  ... .|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGVIQVKLI-EEE-VMSTYTVRTLQIKHLKLKKkkqcnTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDA
|| |.|.|  .|.  .. ||.|.|..|. | ..      .. |.|.|||||||||.|..| ..|....|    . |. ||.|||||||||||||...||.
ygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldi

MLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
.|.|..... |.|. .....|.||. .||..||||||..|..|
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 673-911 2.9e-86 284.1 In-house 1-235 (235) alignment 
Range on Protein: 673-911
Range on HMM: 1-235/235.0
NKRKNRYLNITAYDHSRVHLhptPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP--KDGVET
||.|||| .|..||..||.|    |.... ||||||...||.. ..|| |||||..|.. ||||.|...| .|||.|.|.|.||.||. |||  ... .|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGVIQVKLI-EEE-VMSTYTVRTLQIKHLKLKKkkqcnTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDA
|| |.|.|  .|.  .. ||.|.|..|. | ..      .. |.|.|||||||||.|..| ..|....|    . |. ||.|||||||||||||...||.
ygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldi

MLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
.|.|..... |.|. .....|.||. .||..||||||..|..|
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 673-912 5.7e-63 207.2 In-house 7-239 (239) alignment 
Range on Protein: 673-912
Range on HMM: 7-239/239.0
NKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINANFIDGYQK-GHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPkDGVETY
|| |||| || .|||||| |     .    |||||...  |.   .|.| ||| .  .   ||||.|..| ..|||.| |.|  ..||  ||| |    |
nkaknryanivtydhsrvvlekls.ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsky

GVIQVKLIEEEVMSTYTVRTLQIKHLklkkkKQcNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLK
  ..| | . ||.. | .||. . ..      |   |. |||||.| |||.| |..   || . .| .  .   | | |.||||||||||...|.||||.
cnlrvtlrktevfadyiirtfvmsqv.....gq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEA
| .... |..| ... || .| ..||| |||.|.| |..||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
0041856 (Phosphotyrosine protein) phosphatases II 673-916 1.5e-53 176.4 In-house 1-174 (182) alignment 
Range on Protein: 673-916
Range on HMM: 1-174/182.0
NKRKNRYLNITAYDHSRvhlhptpgqkkNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITnlvergrrkCDMYWPKDGvetyg
|. |||| .|  |||||           .|||||||...|....  || |||||..|. .|.||..|... .||..|         ...|||..      
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

viqvklieeevmstytvrtlqikhlklkkkkqcntEKLVYQYHYTNWPDHGTPDhPLPVLNFVKKSSAanpaEAGPIVVHCSAGVGRTGTYIVLDAMLKQ
                                   |.|..||.|..|||||.|| .  .|.|...  .    | ||..||||||||||||..... |.|.
...................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl

iqqkNiVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG
    . |...  ....| .|.  |.|..||.||..|| | .  .
....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 673-910 2.5e-39 129.7 In-house 55-286 (305) alignment 
Range on Protein: 673-910
Range on HMM: 55-286/305.0
NKRKNRYLNITAYDHSRVHLHPTPgqkkNLDYINANFIDGY-QKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETY
.. |||| .. . |.| |.|.  .      ||| ||..       . || .|||| .| | || |. ...|  |||. . || |. ||  |||    |  
aitknryqdvpcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

GVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVkksSAANpAEAGPIVVHCSAGVGRTGTYIVLDAMLK
 .    ..|.   |    |  .|.   |.     . .  | . ..|.||| | |   |  |...   ||       |||||||||.||||| . .. .|.
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell...sair.gskvpivvhcsagigrtgtivaieyile

QIQ-QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALV
.|  .|.   .  ... .| || | .|.. ||.|.|  ..
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 673-835 1.1e-06 21.6 In-house 27-165 (169) alignment 
Range on Protein: 673-835
Range on HMM: 27-165/169.0
NKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINAnfidgyqkghafigtqgplpdtfdcfwRMIWEQRVAIIVMITNLVERgrrkcDMYWPKDgvETYG
|. |||     |  | ||.|.    ..   |||||                           |||||   ..||.. .  ..     . .||.   | | 
netknrpagplapshtrvklqrvm.edlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek..edyq

VIQVKLIEEEVMSTYTVRTLQIKHL------------KLKKKKQCNTEKLVyQYHYTNWPDHGTPDHPLPVLNFV
.    .. |    .  ||| ... .             ... ..  ||||   .||. ||. | |. |. | ...
lhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvtekls.llhystwpqngvpqspvhvghlf
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 673-838 2.3e-06 20.5 In-house 26-167 (169) alignment 
Range on Protein: 673-838
Range on HMM: 26-167/169.0
NKRKNRYLNITAYDHSRVHLHPTPgQKKNLDYINAnfidgyqkghafigtqgplpdtfdcfwRMIWEQRVAIIVMITNLVERgrrkcDMYWPKDgvETYG
|. |||     |  | ||.|.    ..   |||||                           |||||   ..||.. .  ..     . .||.   | | 
netknrpagplapshtrvklqrvm.edlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek..edyq

VIQVKLIEEEVMSTYTVRTLQIK------------HLKLKKKKQCNTEKLVyQYHYTNWPDHGTPDHPLPVLNFVKKS
.    .. |    .  ||| ...             | ... ..  ||.|   .||. ||. | |. |. | .....|
lhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqls.llhystwpqngvpqspvhvghlfhhs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 675-904 3e-31 103.3 In-house 52-272 (301) alignment 
Range on Protein: 675-904
Range on HMM: 52-272/301.0
RKNRYLNITAYDHSRVHLHpTPGQKKNldyINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVI
 |.|| ..    .. |..  . |..     | ||.|.   . | || |||||..| . || |.    |  |||... ||.  .||. | | .  |.  . 
dkhryptvPckPstavevi.vdGkrvP...ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

--QVKLIEEEVMSTYTVrtlQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPL---PVLNFVKKSSAanpaeagPIVVHCSAGVGRTGTYIVLDAM
  ..|. ..|..    .   . ..|...   .  . . |  | |..|.|.|.|        ....||||         |||||||||.||. ..|  . .
rfkikiknkelilnkki...skrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteyl

LKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIF
 .... .. ...   |.|.| .|   |||..|  .
areveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 680-944 1.3e-16 55.6 In-house 25-288 (290) alignment 
Range on Protein: 680-944
Range on HMM: 25-288/290.0
LNITAYDHSRVHLHpTPGQKKNLDYINANFIDgYQKGHAFIGTQGPLPDT-------FDCFWRMIWEQRVAIIVMITNLVERGRR----KCDMYWPKD--
|...   ..|| |.   |.. | ||| ||..  . .| ..| || |. ..          || |. . .|  .||. .  |. .      |  | |.   
levpLveatrvvLk.gygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg

GVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklKKKKQCNteklVYQYHYTNWPDHGTPDHPLPVLNFVKKSSaanpAEAGPIVVHCSAGVGRTGTYIVL
.  ... ..||  . |      .|.| .|.    ....      |  . . .| .  ...... .|. ..|      |.  |..|||  |. |  .   .
eelkfkgltvkCkskekeddvetRelvvkf...ddeeeft....vtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaai

DAMLKQIQ-QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEelKNCTPYLEQQYKNIIQ
.     |  ... |..   |  .| ||. ........ |   ..|  .     . . |. |  |.   . .. ||.| |
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete..kkakaeeketykkikq
0044763 (Phosphotyrosine protein) phosphatases II 685-909 1.2e-38 127.8 In-house 2-167 (178) alignment 
Range on Protein: 685-909
Range on HMM: 2-167/178.0
YDHSRVHLHPTPGQKKnLDYINANFIDGYqkghAFIGTQGPlpdtfDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVetygviqvklieeevm
.|..||.|.. .|     |||||..|...     ..|...|      .......|. .  ||..|. .|.|. ||| |||..                  
ldrtrvllsnlegler.sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

stytvrtlqikhlklkkkkqcnteklvYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQiqqkNIvNVFGF
                           .||.....||||.|| .  .|.||.   .| . . ||..|||||||||.|| .... |.|.    .. ...  
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleea

LRHIRAQRNfLVQTEEQYIFLHDAL
....|..|.  |....|. .|..  
ielvrerRp.ivpnpgqlrqLyefe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 685-824 1.3e-09 32.4 In-house 5-126 (130) alignment 
Range on Protein: 685-824
Range on HMM: 5-126/130.0
YDHSRVHlhptpgqkkNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERgrrkcDMYWPKD-GVETYgviqvkliEEEV
.. ||..         . .||||.|.   ..   .. || || ||   ||.|. |. | ..|..  . |      | |||    .| |        ||..
fevsrlq.........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewy........eedi

MSTYTVR--TLQIKHLKLKKKKQCNT-EKLVYQYHYTNWPDHGT
. | | |    .||  .|. ... |   . .  .. .|||  ||
ivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 686-904 1.7e-22 74.8 In-house 19-212 (255) alignment 
Range on Protein: 686-904
Range on HMM: 19-212/255.0
DHSRVHLHPTPG-QKKNLDYInanfidgyqkghafigtqgplpdTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVM
|    |..|    ..|||. .                       | | |...|  ..   .||.... | |. ||. |.| .  |   . .|...  . .
dvctehvkPekdkkrknlysl.......................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkss

STYTVRTLQIKhLKLKKKKQCNTeklVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAAnpaeaGPIVVHCSAGVGRTGTYIVLD----AMLKQIQQKNIVN
.   .|||.|  ..| .||. .|   |  |.|. |... .|. .  .|| .|    .      ..|||||.|.||. .... .     |...... . |.
advvlrtleit.stlgekkktht...vkhysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetve

V--FGFLRHIRAQRNFLVQTEEQYIF
.    .|...| .|.  ..|  |  |
ldylslleelrskrkraihtPlqlaf
subfamily_hpo-7_pd Subfamily hpo-7 686-901 7.1e-19 62.7 In-house 22-215 (263) alignment 
Range on Protein: 686-901
Range on HMM: 22-215/263.0
DHSRVHLHPTPG-QKKNLDYInanfidgyqkghafigtqgpLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVM
|    |..|    ..|||. .                    | .| | |...|  ..   .||...  | |. ||. |.| .  |   . .|..   .|.
dvctehfkPekdkkrknlysl....................lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvq

STYTVRTLQIKHlKLKKKKQCNTeklVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAAnpaeaGPIVVHCSAGVGRTGTYIVLD----AMLKQIQQKNIVN
|   ..||..    |..||. .|   | .| |. |...  |  .  .|| .|           ..|||||.|.||.  . | .     |...... . |.
sdvllktlells.tlgeKkktht...vkhysykgWiekndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstve

V--FGFLRHIRAQRNFLVQTEEQ
.    .|...| .|.  ..|  |
ldylsLleelrssrkraihtPmq
0046846 (Phosphotyrosine protein) phosphatases II 699-910 1.6e-43 143.8 In-house 9-170 (176) alignment 
Range on Protein: 699-910
Range on HMM: 9-170/176.0
KKNLDYINANFIDGYqkghAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKdgVETYGViqvklieeevmstytvrtlqikhlk
  .|||||||.|.|.    ..| ||||||.|.  |..|..|... ..|..|..|| || ||. |||   .|..|.                         
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.........................

lkkkkqcnteklvyQYHYTNWPDHGTPDHpLPVLNFVKKSSAANPAEaGPIVVHCSAGVGRTGTYIVLDAMLKqiqqKNIVNVFGFLRHIRAQRN-FLVQ
              ||....|||||.||.   .|....    |  .  ||..||||||.|||||..... . .    .. ..|.  |...|.||  . ||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavq

TEEQYIFLHDALV
|.||| ||.... 
tpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 700-906 3.9e-43 142.5 In-house 3-154 (172) alignment 
Range on Protein: 700-906
Range on HMM: 3-154/172.0
KNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLvergrrkcdmywpkdgvetygviqvklieeevmstytvrtlqikhlkl
.. |||||...|.| . . || |||||. |.. ||||..|. . .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

kKKKQCNTEKLVYQYHYTNWPDHGTPdHPLPVLNFVKKSSA-ANPAEAGPIVVHCSAGVGRTGTYIVLDAMLkqiqqKNIvNVFGFLRHIRAQRNFLVQT
  .   . |.|..||.|..|||||.| ..  .|.|..     ..  . ||..|||||||||||| .... ||     ... ...  ....|..|.  ||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqn

EEQYIFLH
..||.||.
psqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 703-942 9.4e-54 178.1 In-house 5-250 (272) alignment 
Range on Protein: 703-942
Range on HMM: 5-250/272.0
DYINANFIDGYQK---GHAFIGTQGPLPDTFDCFWRMiWEQRVAIIVMITNLVERGRRKCDMYWP------------KDGVETYGVIQVKLIEEEVMSTY
.||||....|| .    .... ..|||| | . |||. .|...  ||......|||| |||.|||             .   .|| . |.|..||... |
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

TVRTLQIKHLKLKKKKqcnteKLVYQYHYTNWPDHGTPDHPlpVLNFVKKSSAanpaeAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVN-------
..|.|....|   ..        |...|||.|||||.|...  .|....   .      ||..||||||..||||...|. .| ..    ||.       
ilrellltlllsagea.....revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIasgeTNLMAEQVEELKNCTPYLEQQYKNI
 ........||||   |||||||.||..||.|..     .|.. ..| |.    .....| ..
yleeaveelraqrpgavqteeqylflyeallell....rsllsvraeyllaaldaideeyGsv
0036282 (Phosphotyrosine protein) phosphatases II 703-907 3.3e-48 159.0 In-house 3-164 (174) alignment 
Range on Protein: 703-907
Range on HMM: 3-164/174.0
DYINANFIDGYQKGHAFIGTQGPLPdtfdcFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKdgvetygviqvklieeevmstytvrtlqikhlklkkk
|||||...|..     .| .||||.     ||.|..|... ..|| ....|.|. ||  |||                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

KQCNTEKLVYQYHYTNWPDHGTPDHPLpVLNFVKKSSAANPA-EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQqKNIVNVFGFLRHIRAQRNFLVQTEEQ
..   |.|..||.|..|||||.|| .  .|.|||    |    . ||..|||||||||||| .... ||...   . |... ..| .| ||   |||..|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YIFLHD
|.||..
yrflyy
0051082 (Phosphotyrosine protein) phosphatases II 703-909 2.4e-34 113.5 In-house 4-149 (151) alignment 
Range on Protein: 703-909
Range on HMM: 4-149/151.0
DYINANFIDGYqkghaFIGTQGPLPdtfdCFWRMIWEQRVAIIVMITNLVERGrrKCDMYWPKDGvetygviqvklieeevmstytvrtlqikhlklkkk
||||.....|.     .. ..|||.     |.....|. .  ||......|||  .|  |.|. |                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

kqcnteKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAanpAEAGPIVVHCSAGVGRTGTYIVLDAMLKQiqqkniVNVFGFLRHIRAQRNFLVQTEEQY
        |.......|||.|.|...  ||.|...  .    . ||..||||||.||||| ..|. || .      |...  |...|..|  .||...|.
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

IFLHDAL
.|.. ||
lfqlfal
0049260 (Phosphotyrosine protein) phosphatases II 709-907 2.3e-43 142.8 In-house 1-144 (152) alignment 
Range on Protein: 709-907
Range on HMM: 1-144/152.0
FIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWpkdgvetygviqvklieeevmstytvrtlqikhlklkkkkqcnte
||||| ....||.||||.| |.. ||||..|. . .|||.|.|.|.|. ||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

klvyQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLkqiqqkNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHD
    ||....|||||.||..  .| ...    ..  . ||..||||||||||||..... ||      . |... .....|..|.  |....|..||..
....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 711-796 3.8e-12 40.3 In-house 230-313 (440) alignment 
Range on Protein: 711-796
Range on HMM: 230-313/440.0
DGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVErgrRKCDMYWPKDG-VETYGVIQVKLIEEEVMSTYTVRTLQIKH
.|| |  ||| || ||  |   |||.. . |.. |.|. .| .   . | .||| .    |.| . |     | |    ||||..|.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 717-906 1.4e-17 58.5 In-house 5-197 (199) alignment 
Range on Protein: 717-906
Range on HMM: 5-197/199.0
HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPK--DGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklKKkKQCNTEKLVYQY
. .| || || .|.  ||.|.||     |||. .          .|||    |.  || . |      . . ||. .| .     .      . . . .|
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn...nt.tappstreishy

HYTNWPDHGTPDHPLPVLNFVKKSS---AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQ--QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLH
 .| | .. ||.  | |   |         .     |..|||| | | || .. ||  ..  .  .  .|..|   . .|  |  .. . ..| |..
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 718-906 1.6e-17 58.4 In-house 5-196 (198) alignment 
Range on Protein: 718-906
Range on HMM: 5-196/198.0
AFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPK--DGVETYGVIQVKLIEEEVMSTYTVRTLQIKHlklKKkKQCNTEKLVYQYH
 .| || || .|.  ||.|.||     |||. .          .|||    |.  || . |      . . ||. .| .     .      . . . .| 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn...nt.tappstreishyq

YTNWPDHGTPDHPLPVLNFVKKSS---AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQ--QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLH
.| | .. ||.  | |   |         .     |..|||| | | || .. ||  ..  .  .  .|..|   . .|  |  .. . ..| |..
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 725-906 5.5e-25 82.4 In-house 99-281 (302) alignment 
Range on Protein: 725-906
Range on HMM: 99-281/302.0
PLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD--GVETYGVIQVKLI--EEEVMSTYTVRTLQIKHLKLKKK-KQCNTEKLVYQYHYTNW
|  .| . .| .| . .|||.| ....|| . .||  |. ..  |. ..|   || .  ....      .....  ...| . |. ...| |   ... |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGTPDHPLPVLNFVKKSSAANPAeagpIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLH
||||.|... . |. .|   .   .    ..|||||||||||| . .   ..  ..|.. ..   .  .|. |   ||.|.| |.| 
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
0048076 (Phosphotyrosine protein) phosphatases II 791-909 3.9e-27 90.1 In-house 27-139 (145) alignment 
Range on Protein: 791-909
Range on HMM: 27-139/145.0
TLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEaGPIVVHCSAGVGRTGTYIVLDAMLKqiqqKNiVNVFGFLRHIRA
 |.|...      . . |.|..||.|..|||||.|| .  .|.|..   .| ... ||..||||||||||||..... ||.    .. |...  |...|.
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrs

QRNFLVQTEEQYIFLHDAL
|| . |....|..||....
qrpgavpnpgqlrflyefe
subfamily_PTEN_pd Subfamily PTEN 797-903 5.4e-06 21.5 In-house 65-172 (184) alignment 
Range on Protein: 797-903
Range on HMM: 65-172/184.0
LKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLpVLNFVKKSSAA-NPAEAGPIVVHCSAGVGRTGTYIVLdAMLKQIQQKNIVNVFGFLRHIRAQRNFL
. |. ... ...|.  . . ..  || .|   | . ..|.. ..  .  .   .|||| || ||||. ||   .||. . ..  ..  .  ..|.. .  
ynlrserkydskkfdgrvavypfdDhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkg

VQTEEQ--YI
|.   |  |.
vtiPsqrRYv
0048179 (Phosphotyrosine protein) phosphatases II 806-907 5e-26 86.5 In-house 44-139 (144) alignment 
Range on Protein: 806-907
Range on HMM: 44-139/144.0
NTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEaGPIVVHCSAGVGRTGTYIVLDAMLkqiqQKNiVNVFGFLRHIRAQRNFLVQTEEQYIFL
  |. ..||....|||||.||..  .|.|..   .| . . ||..||||||||||||..... |.     .. ....  |...|..| . |....|..||
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

HD
..
le
0038934 (Phosphotyrosine protein) phosphatases II 806-886 3.2e-09 32.2 In-house 74-156 (194) alignment 
Range on Protein: 806-886
Range on HMM: 74-156/194.0
NTEKLVYQYHYTNWPDHGTP---DHPLPVLNFVKKSSAANPaeAGPIVVHCSAGVGRTGTYIVLDAMLK-QIQQKNIVNVFGFLR
  ||. ..|.   .||.||.   .  |  |..|..  ...|   | ..||| ||.||||| ..   . . ..  .  .. | . |
efekagieylklpfpddgtvPsleillrfldlvdeflnedp..ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 809-934 2.1e-26 87.3 In-house 89-219 (440) alignment 
Range on Protein: 809-934
Range on HMM: 89-219/440.0
KLVYQYHYTNWPDHGTPDHPLPVLNFVKKSS-AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHD
. . ||||  |||.| |    |||....  . . . |  ||..||||||.||||  |..|..|.. .. . ...| |.  .| .|  .||| ||| |.|.
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

ALVEAIASGETNLMAE----QVEELKNCTPY
|..|.. .|.| .. .    .||...   |.
avlegllcgdtliledditerveqiqwpnph
PTEN_1 810-897 7.2e-08 27.5 In-house 93-179 (196) alignment 
Range on Protein: 810-897
Range on HMM: 93-179/196.0
LVYQYHYTNWPDHGTPDhPLPVLNFVKKSSAANPA--EAGPIVVHCSAGVGRTGTyiVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQ
  ..|.   ..|||.|.    .. ..|.   .  .  . . ..||| ||.||.||  |. | | . .. .  . . ..|  | ....   
sgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGt..vvaayLmykgkltadeAlelvrekRppgapnsp
PTPc_DSPc_SM00012 811-910 2.2e-35 116.4 In-house 2-104 (105) alignment 
Range on Protein: 811-910
Range on HMM: 2-104/105.0
VYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEA--GPIVVHCSAGVGRTGTYIVLDAMLKQIQQK-NIVNVFGFLRHIRAQRNFLVQTEEQYIFLHD
|..||||.|||||.|... ..|.....    . ...  .|.|||||||||||||...|| .|.|.... . |..| .....| ||. .|||||||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALV
|| 
all
subfamily_PTPDC1_pd Subfamily PTPDC1 811-907 4.8e-07 24.4 In-house 83-170 (182) alignment 
Range on Protein: 811-907
Range on HMM: 83-170/182.0
VYQYHYtNWPDHGTPDHpLPVLNFVKKSSAAnpAEAGPIVVHCSAGVGRTGTYIVLDAMLKQ-IQQKNIvnvfgfLRHIRAQRNFLVQTEEQYIFLHD
.| | .  |.|.|..     .|. ||  . |   . | . ||| || ||||  |    . .. .. ..       .. .|..|   .|| ||  ....
iyvynf.gwkDygvasl.eriLdivkvvafa..lqegkvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvke
subfamily_CDC14_pd Subfamily CDC14 829-891 3.6e-07 24.3 In-house 246-306 (328) alignment 
Range on Protein: 829-891
Range on HMM: 246-306/328.0
LPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLdAMLKQIQQkNIVNVFGFLRHIRAQ
 |  . |||  ..     | |.||| ||.||||| |    ..|. .  .  .. ..|| .|  
tPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkhyrf.taaeaiawlricrPG
PTPc_motif_SM00404 831-891 4.3e-06 21.7 In-house 69-123 (140) alignment 
Range on Protein: 831-891
Range on HMM: 69-123/140.0
VLNFVKKSsaanPAEAGPIVVHCSAGVGRTGTYIVLDAMlkQIQQKNIVNVFGFLRHIRAQ
||.|....     .. | ..||| ||| |..| |.   |  . .| .. ... |... | .
vldfiena....ekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerRpi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 839-911 8.5e-17 55.9 In-house 222-293 (297) alignment 
Range on Protein: 839-911
Range on HMM: 222-293/297.0
SAANPAEAgPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE
 |. | .| ...|||||||||.|  .  |..|.....| | .|  .|...| ||  |||| ||. .|.|| ..
raemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 840-909 5.8e-13 43.2 In-house 241-311 (319) alignment 
Range on Protein: 840-909
Range on HMM: 241-311/319.0
AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQK-NIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDAL
...  . ||.||||| ||||||. |  |  ......  . |..   . ..| .|   |.| ||| |..  |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 849-916 3.2e-17 56.7 In-house 1-68 (69) alignment 
Range on Protein: 849-916
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG
.|||||.| |||||.| .   . .|. . .|..|  ....|  |  .|  | .|||.|||||||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 850-916 2.1e-16 54.0 In-house 1-67 (69) alignment 
Range on Protein: 850-916
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG
|||||.| |||||.| .   . .|. . .|..|  ....|  |  .|  |..|.|.|||||||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
0045450 (Phosphotyrosine protein) phosphatases II 920-1186 5.7e-55 182.6 In-house 14-302 (307) alignment 
Range on Protein: 920-1186
Range on HMM: 14-302/307.0
LMAEQVEELKNCTPYLEQQYKNIIQFQPK-DIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGE-DGSDYINASWL--------HGFRRLRDFIVTQ
|. .. ..|...   |..... .......  ... .|....|  |||   |.| . .||.|.. .|. ..|||||||.         .|... | ||.||
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

HPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINF---AQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSI-QDDYELTVKMLHCPSWPEMSNP--
.|. .|..|||.|.|... ...| |..|.. ..   ||.|||| .... ....|..|... ...|. | . ..   ......||. .|...||... |  
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

-NSIYDFIVDVHERCNDY-RNGPIVIVDRYGGAQACTFCAISSLAIEMEYCST---ANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSF
 ... |||  |.. .... ..||...  . |   ..||.|.  .   .|.  |    ....  ||. ..|||. .. | .| .|..| .
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 922-1186 1.9e-54 180.5 In-house 21-287 (297) alignment 
Range on Protein: 922-1186
Range on HMM: 21-287/297.0
AEQVEELKNCTPYLEQQYKNIIQFQPkDihIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGE-DGSDYINASWLHGFRR-LRDFIVTQHPMAHTIKDF
. .  | .|.. .|...........| |  .  |....|  |||   |.| . |||.|.|..|   .|||||||.. |...  |.||.||.|. .|..||
lllllekansktllllefeellslkp.d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WQMVWDHNAQTVVLLSSLDDIN--FAQFWPDEATpiESDHYRVKFLNKTNKSDYVSRDFVIQSiqDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVH
|.|||... ...| | .|.. .  .||.||.| .  . ....|..|. . ...|. | . ..   .....||.......||... |   .....|.  |.
wrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

ERCNDY-RNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSF
|... . ..||...    |   ..||.|.  .   .|.  . .|..  | . ..|||. .. . .| .|..| .
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 922-1142 7e-21 69.2 In-house 8-233 (439) alignment 
Range on Protein: 922-1142
Range on HMM: 8-233/439.0
AEQVEEL-KNCTPYLEQQYKNIIQFQPKDIHIASAMKQ-VNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDF
 |.||.| ||    ... ...|   .|.   ||| . |  .  |||   . . . .|| |   ||   | |||| ...|.   . .| || |  .| .||
qehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WQMVWDHNAQTVVLLSSLDDinFAQFWPDEATPIESDhYRVKFLNKTNKSDYVSRDFVIQSIQD--DYELTVKMLHCPSWPEMSNPN---SIYDFIVDVH
|..|..... |.| |. | .    ..|| .|  .  |   |.   . .  .|| | | .   .|  . | ||  .|  .||.   |     . ||.  . 
wrlviekktvtivmltnlve..sykywpsdaevcygd.iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain

ERCNDYRNGPIVIVDRYGGAQACTFCAIS
   ..   ||.|.    |  .. |  |. 
sandkeeygpvvvhcsagvGrtGtiiald
subfamily_PTPRD_pd Subfamily PTPRD 923-1183 2.6e-54 179.8 In-house 12-276 (564) alignment 
Range on Protein: 923-1183
Range on HMM: 12-276/564.0
EQVEELK-NCTPYLEQQYKNIIQFqpKDIHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQ
| |..|| |.   .|..||.| .   .  .. .| |..|  ||| | | . . ||| |.. .|..||||||||...|.|. . .| ||.|.|.||.|||.
ehvaklkansdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWR

MVWDHNAQTVVLLSSLDDIN---FAQFWPDEAtPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNS---IYDFIVDVHE
|||..| .|.|.|..| . .   ....||..  . . ... |.. ......||. |.| ..  ...   .|.  |  |||.   |.|   . |.| .|..
mvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvra

RCnDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI
      .||||.    |     ||..|...   ...  | ..||| |.  ..|. .  . |    |...
ln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFihea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 923-1184 3.5e-47 156.0 In-house 9-276 (318) alignment 
Range on Protein: 923-1184
Range on HMM: 9-276/318.0
EQVEELK-NCTPYLEQQYKNIIQFQPKDIHIASaMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQ
..|..|. . . .|...|... . . .  .. | ...||  ||| | | . . .||.|... || |||||||... |.|| . .| .| |...||.|||.
shvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWr

MVWDHNAQTVVLLSSLDD---INFAQFWPDEAtPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNS---IYDFIVDVHE
|||. |....|.|. . .   .  ...||..  ... .. .|.  .... |||| | | ..  . . . .|.  |. |||. . |.|   . |.. .|..
mvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvsk

RCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
  ..  .||||.    |  .. .|.|...|   ..  .. .|.|. |   ..|. .    .   .||..|
aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvl
0051299 (Phosphotyrosine protein) phosphatases II 926-1184 1.4e-60 200.6 In-house 16-282 (288) alignment 
Range on Protein: 926-1184
Range on HMM: 16-282/288.0
EELKNCTPYLEQQYKNIIQFQPKdIHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWD
. |.|.. .|..... .....|. ... .|... |  |||   |.| . |||.|.. .|..||||||||...|... | ||.||.|. .|..|||.|||.
kllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvwe

HNAQTVVLLSSLDDIN---FAQFWPDeATPIESDHYRVKFLNKTNKSDYVSRDFVIQSI----QDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHE
.| ...| | .|.. .   .||.||.  .... ....|..|. . ..||. | . .. .    .|....||. .|...||... |.   .. ||. .|..
qnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

RCNdYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
 ..  ..||.|.  . |   ..||.|.  |   .|.  . .|... | . ..|||. .. | .| .| .|
ala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
subfamily_Ptp69D_pd Subfamily Ptp69D 926-1184 3.2e-42 139.7 In-house 14-282 (307) alignment 
Range on Protein: 926-1184
Range on HMM: 14-282/307.0
EELKNCT-PYLEQQYKNIIQFqPKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVW
.  |. |   |.. |... .    |     . |. | .|||  .| . .  || |.. .|.. |||||||...|..  ..||. | |.  ||.|||.|..
ksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia

DHNAQTVVLLSSLDDINF---AQFWPDEaTPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQD-----DYELTVKMLHCPSWPEMSNPN---SIYDFIVDV
. . ...|.|| |.. |    |..||.| . .. ..  ||. .. ..|||. |.. .  ...     . .  |   |  .|...  |.   .. ..|  |
eqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

HERcNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
.|  .   ..|||.  . |  .. .| |..||  ...   ......  |  ...|. . .| |    .|  |
rel.yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
0043336 (Phosphotyrosine protein) phosphatases II 928-1184 2.8e-56 186.4 In-house 15-273 (278) alignment 
Range on Protein: 928-1184
Range on HMM: 15-273/278.0
LKNCTPYLEQQYKNIIQFQPkdIHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHN
|.|.   |....... .|..  ...  |... |  |||   |.| . |||.|.. .|. .|||||||.. |... |.||.||.|. .|..|||.|||...
llnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

AQTVVLLSSLDDIN---FAQFWPdeATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNdYR
 .|.| | .|.. .   .||.||   .... ....|..|. . ..||. |.. .   .|....||  .|...||... |   ... ||. .|.|...  .
vttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.ds

NGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
|||...  . |   ..||.|.  |   .|.  . ....  | . ..|||  .. . .| .|..|
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_PTPRN_pd Subfamily PTPRN 928-1176 5.8e-30 99.0 In-house 25-280 (297) alignment 
Range on Protein: 928-1176
Range on HMM: 25-280/297.0
LKNcTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGF-RRLRDFIVTQHPMAHTIKDFWQMVWDH
|||    ||.... . ... ..   . | .. |  |||  |..| . |||.|. .  .. ||||||| .     |   .| || |.|.|. |||||||..
lkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

NAQTVVLLSSLDDI---NFAQFWPDEATPIEsDHYRVKFLNK-TNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHeRCND
 .  .| |..|..    . ...|||| . .  . | |... .     ||. | | .. .| .   ||  .|  ||||.. |    |. .|   |  ..  
GvvvivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyr

YRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCsTANVYQYAKLYH--NKRPGVWTSSED
 |  |||.    |  .. ....|  .   .      ..   | | |  ..|||.  . ..
GrscpivvhcsdGaGrtGvyilidlvlnrllkG.vkeidiaatlehlrdqrpglvktkdq
0050432 (Phosphotyrosine protein) phosphatases II 929-1184 3.6e-59 195.9 In-house 38-295 (308) alignment 
Range on Protein: 929-1184
Range on HMM: 38-295/308.0
KNCTPYLEQQYKNIIQFQPkDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLtpkpgEDGSDYINASWLHGF--RRLRDFIVTQHPMAHTIKDFWQMVWDH
.... .||.... . ...| .. . .|... |  |||   |.| . |||.|     ..||||||||. .|.  .. | ||.||.|. .|..|||.|||..
aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

NAQTVVLLSSLDD---INFAQFWPDE--ATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNS---IYDFIVDVHERCn
| ...| | .|..   ...||.||.|   ...| ....|..|. ....||. | . .. ..|....||. .|...||... |.|   . ||.  |.... 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

dyRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
  ..||||.  . |   ..||.|.  |   .|.  . .|... |    .|||. .. |  . .| .|
..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral
0047943 (Phosphotyrosine protein) phosphatases II 929-1184 4.3e-58 192.3 In-house 8-268 (273) alignment 
Range on Protein: 929-1184
Range on HMM: 8-268/273.0
KNCTPYLEQQYKNIIQFQPkDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLtpkpGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNA
.... .|..... .....| .. .  |... |  |||   |.| . |||.|    |..||||||||.. |... | ||.||.|. .|..|||.|||..|.
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

QTVVLLSSLDDI---NFAQFWPDEAT--PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDY
...| | .|..    ..||.||.|    ... ....|..|. ..|.||. | . ..........||. .|...||... |   .|. .|| .|.. .. .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-RNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
 .|||.|.  . |   ..||.|.  |   .|.  . .|... ||. ..|||. .. | .| .|..|
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 929-1185 1.1e-56 187.8 In-house 14-273 (317) alignment 
Range on Protein: 929-1185
Range on HMM: 14-273/317.0
KNCTPYLEQQYKNIIQFQPKdiHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNA
|.   .|............   ..  |....|  |||   |.| . |||.|.| .|  .|||||||. .|... | ||.||.|. .|. |||.|||... 
ksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

QTVVLLSSLDD---INFAQFWPDeATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNdYRN
...| | .|..   ...||.||.  .... ....|..|. . ..... | . ..  .|....||. .|...||... |   ... ||.  |.| ..  ..
tvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpg

GPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS
||...    |   ..||.|.  .   .|.  . .|..  | . ..|||.... | .| .| .| 
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
0036941 (Phosphotyrosine protein) phosphatases II 929-1187 2.3e-55 183.4 In-house 9-276 (297) alignment 
Range on Protein: 929-1187
Range on HMM: 9-276/297.0
KNCTPYLEQQYKNIIQFQPkDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLtpkpGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNA
.... .|..... . .... ....  |... |  |||   |.| . .||.|    ...||||||||.. |... | ||.||.|. .|. |||.|||..| 
llflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

QTVVLLSSLDDINF---AQFWPDE-ATPIESDHYRVKFLNKTN--KSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCND
...| |..|.. ..   ||.||.|   ... ....|..|. .   ..||. | . .. .......||...|...||... |   .|. |||  |..... 
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

Y-RNGPIVIVDRYGGAQACTFCAISSLAIEME---YCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFL
. ..||...  . |   ..||.|.  .   .|   .  . ..... | . ..|||. .. |  | .| .| .|
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 929-1183 3.4e-50 166.0 In-house 24-285 (298) alignment 
Range on Protein: 929-1183
Range on HMM: 24-285/298.0
KNCTpYLEQQYKNIIQFQP--KDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDH
|. |  ........ . .   .. .   | |. |  |||   | ... ||| |. . ... |||||||.||....   ||.||.|. .|..|||.||...
kklt.gyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvtee

NAQTVVLLSSLDDI---NFAQFWPDEATpIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDY
...|.|.| .| .    .. ..|||| .  . .. .|. |.| ...|...| . ... . . | .|..||  |||. . |   .|. |.. .|.   .. 
digtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa

RNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI
 | |...    |   . ||.||.|.   ..  ..  |.|. |   .||||. .. |.   ||..
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyea
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 929-1185 3.1e-23 76.9 In-house 11-290 (301) alignment 
Range on Protein: 929-1185
Range on HMM: 11-290/301.0
KNCTPYLEQQYKNIIQFQPKDIHI--ASAMKQVNSIKNrgaIFPIEGSRVHLTPKPGED--GSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWD
.. .  .|.|||.. . ..|  ..   .. |..|. ||   | ...  |. |.|||  |    .|||||...|... . ||..| || .|..|||...|.
akhsnkfeeqykelkegedksctvglseenkalnrfkn...itvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

HNAQTVVLLSSLDDI---NFAQFWPDEAT-PIESDHYRVKFLNKTNKSDYVSRDFVIQsIQDDY----------------ELTVKMLHCPSWPE---MSN
.  ...| .  |..    .  |.||.  .   |  .  |.. |...  |.| |.. .. |||                    .|  |.  .||.   . .
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvk.iqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

PNSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISslaIEMEYCST---ANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS
|. .   | ||  | .    ||.|.    . ... ..|..|   | .| |      .|.|  |    ..||. |  |    ||....
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvs...iglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 930-1184 5.8e-42 138.9 In-house 20-279 (319) alignment 
Range on Protein: 930-1184
Range on HMM: 20-279/319.0
NCTPYLEQQYKNIIQFQPKdiHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQ
. . .||...|.. . ...  .. || |. |. |||   | ... .|| |.. .| .||||||||.. |... . || || |...||.|||.|||.... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

TVVLLSSLD---DINFAQFWPDEaTPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYE-LTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCNDYRN
.||.|. |    .... ..||.| .. |  .. |. ... ...||. |.. ..  ... |  .||  .  .||.   |.   |. |.. ....  .   .
ivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

GPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
||||.    |     ||....     ..  .. .|.....    .|. .    |  ..||..|
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeal
0045098 (Phosphotyrosine protein) phosphatases II 931-1186 4e-45 149.7 In-house 6-270 (278) alignment 
Range on Protein: 931-1186
Range on HMM: 6-270/278.0
CTPYLEQQYKNIIQFQPkdIHIASAMKQVNSIKNRGA-IFPIEGSRVHltpkpgedgsDYINASWLHGFrRlRDFIVTQHPMAHTIKDFWQMVWDHNAQT
....| . . ......|    |  |..  |  |||   |.|.. |||.          ||||||...|. . . ||.||.|. .|. |||.|.|... ..
sldlllefefllllgip..seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitv

VVLLSSLDDI---NFAQFWPDeATPIESDHYRVKFLNKTNKSDYVSRDFVIQSI----QDDYELTVKMLHCPSWPEMSNPNSI-----YDFIVDVHERCN
.| | .| .     .||.||.   ... ....|..|. .. .||. |.. .. .    .|.....|..||...||... |..       ...  ..|...
ivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

------------DYRNGPIVIVDRYGGAQACTFCAISSLAIEMeyCSTANVYQYAKLYHNKRPG-VWTSSEDIRVIYNILSF
            . ..||...  ..|   ..|..|.  .   .   .. ..... | . ..||| .... | .| .|  |  
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPN23_pd Subfamily PTPN23 931-1149 8.3e-30 98.6 In-house 13-240 (288) alignment 
Range on Protein: 931-1149
Range on HMM: 13-240/288.0
CTPYLEQQYKNIIQFQPKDIHI-ASAMKQVNSIKNRG-AIFPIEGSRVHLTpkpgEDGSDYINASWLHGFRRL-RDFIVTQHPMAHTIKDFWQMVWDHNA
 .  |....|.. | | |. .  . |. ...| |||   |.| . .||.|     .   ||||||....      |||.|| |.. |. |||.||..  .
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

QTVVLLSSLDDINFA---QFWPDE-ATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHE---RCN
...|.| | .. .     ..|| .   . . ....|   .... . .| |.. ..  . |   .|. |.  ||||.  |.   .. .|.  |..     .
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

DYRNGPIVIVDRYGGAQACTFCAISSLAIEME
   . |.|.    |   . .|. . . ..|.|
rksktPlvvhCsaGvgRtgvfalvyaavrele
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 934-1185 1e-40 134.8 In-house 23-280 (305) alignment 
Range on Protein: 934-1185
Range on HMM: 23-280/305.0
YLEQQYKNIIQFqPKDIHIASAMKQVNSIKNRgAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
 ||.|||....  .. |.. .  ..... ... .|.. . .|..||.|. .| |||||||...|..|   .||.| |. .|..|||.....   .|.|.|
gleaqykslyee.eesidvgkkeankaknrlk.eitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivml

S---SLDDINFAQFWPDEATP-IESDHYRVKFLNKTNKSDYVSRDFVIQS-IQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDYRNGPIV
.     ..    |.||.. |   | ... |.  .... |||. |.. |    .|. . ||  ..  .||.   |    |. ..| .|... .  .. |..
tklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

IVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS
..   | . . .|.|..     ..   . .|... |   .||... .. .    ....| 
VhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdald
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 934-1181 2.5e-34 114.0 In-house 35-284 (319) alignment 
Range on Protein: 934-1181
Range on HMM: 35-284/319.0
YLEQQYKNIIQFQPKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVL
 || ..... .  ..    . |  . |  ||| . |.. . ..| | .  ||..|||||||.. |..|   .| .| |.  |..|||.|.|..|. |.||
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LSsldDINFAQFWPDEATpIESDHYRVKFLNKTNKSDYVSRDFVIQS-IQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHE----RCNDYRNGPIVIV
|.       .|.|| ..  |. ... ||    .. ..|| ||. .    .      ..  |   ||..  |..  |..  |.     .     . .||. 
lt...kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvh

DRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIY
   |  .. .. ..  |   |.  .  .||.. .   ..|. .  .  .   ||
csaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 934-1049 4.9e-10 33.9 In-house 17-132 (307) alignment 
Range on Protein: 934-1049
Range on HMM: 17-132/307.0
YLEQQYKNIIQFQPKDIHIAsAMKqVNSIKNRGA-IFPIEGSRVHLTpKPGEdGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVL
 | ...... . .|. . .  |..  |. |||   .  .. .|. ..  .|   |||| | .|    . . ||..| |.  |. .|| |. ... ..|..
alvdefrvlakktpegvtve.afs.antdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LSS---LDDINFAQFWPDEA
|     |  |.  |.|| | 
lckvielakikceqywplee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 934-1183 3.2e-08 27.4 In-house 27-280 (302) alignment 
Range on Protein: 934-1183
Range on HMM: 27-280/302.0
YLEQQYKNIiQFQPKDIHIASAMKQvNSIKNRGAIFPIEGS-RVhltpKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTI---KDFWQMVWDHNAQT
 .....|.| . .  |.   .| |. |. ||.   .||  | .|    | ..   .|.||| ..     |  |..| |   .     .||.||.... ..
evkkefkki.dtmkvdlekCkafkk.nlkknqsedvpildsnlv....kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVLLSSLDDI--NFAQFWPDEATPIesDHYRVKFLN--KTNKSDYVSRDFVIQSIQDDYE--LTVKMLHCPSWPEMSNPNSIYDFIVDVHER--CNDYRN
||.|   ...   . ...| ..      .|   |.|  | .|..     .||  . ...   . ... ..  |.. . | .. . |  ...    .   .
vvilvgeeelkktlselfpkksgdy..keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

GPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI
 ..|||  .|   | .| .      ...  .  |. . .|   ..|| .  | .    .| .
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyia
0046845 (Phosphotyrosine protein) phosphatases II 935-1184 8e-58 191.4 In-house 2-270 (284) alignment 
Range on Protein: 935-1184
Range on HMM: 2-270/284.0
LEQQYKNIIQFQPKDI-HIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGE-DGSDYINASWLHGF-----RRLRDFIVTQHPMAHTIKDFWQMVWDHN
||.... ......| . ..  |... |  |||   |.| . |||.|.. .|. ..|||||||...|.     .. . ||.||.|. .|..|||.|||..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AQTVVLLSSLDDIN---FAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQ-DDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCND-
....| | .|.. .   .||.||.| .... ....|..|....|.||. | . .. .. .....||. .|..|||... |   ... .|. .|.| ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

YRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCS---TANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
...||||. .. |   ..||.|.  |   .|. .   . .|... | . ..||| ... | .| .|..|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeal
DSPc_SM00195 935-1186 2e-52 173.5 In-house 2-260 (263) alignment 
Range on Protein: 935-1186
Range on HMM: 2-260/263.0
LEQQYKNIIQFQPKDiHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
|....... . .... .. .| |. |. |||   |.|.. .||.|.......|||||||... | .. ...|.||.|. .|..|||.|||... ...| |
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SSLDD---INFAQFWPDEA-TPIESDHYRVKFLNKTNKS-DYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDYrNGPIV
.. ..   .. ...||.|. .. . ....||. ....|. ... |.. ..  ... . .|. ... .||. . |   .|. ...  |... .   .||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

IVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSF
..   |  ...||..|...  ..|  .. .. .  |   ..|||. ...|  ..||... .
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 935-1186 2e-52 173.5 In-house 2-260 (263) alignment 
Range on Protein: 935-1186
Range on HMM: 2-260/263.0
LEQQYKNIIQFQPKDiHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
|....... . .... .. .| |. |. |||   |.|.. .||.|.......|||||||... | .. ...|.||.|. .|..|||.|||... ...| |
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SSLDD---INFAQFWPDEA-TPIESDHYRVKFLNKTNKS-DYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDYrNGPIV
.. ..   .. ...||.|. .. . ....||. ....|. ... |.. ..  ... . .|. ... .||. . |   .|. ...  |... .   .||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

IVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSF
..   |  ...||..|...  ..|  .. .. .  |   ..|||. ...|  ..||... .
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPRB_pd Subfamily PTPRB 935-1157 1e-37 124.8 In-house 27-254 (293) alignment 
Range on Protein: 935-1157
Range on HMM: 27-254/293.0
LEQQYKNIIQFQpKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
. ..|... ... ||  ...| ..||. |||   | | . |||.|..  .|.|||||||....|..  |.||.|| |. .|..|||.|||.......|.|
fseeyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivml

SSLDD---INFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSiqDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERC-NDYRNGPIVI
  | .   .   ..||.. .|.   . .|.........|.| |.. |.   .. | .|. .|  |||.   |.   .. ||.  |.|.  .. ...|||.
tqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

VDRYGGAQACTFCAISSLAIEMEYCSTANVY
    |   . || |.  |  ..|   . ...
hCsaGvGRtGtfialdrllqaieeedyvdif
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 935-1184 7.3e-37 122.0 In-house 23-275 (288) alignment 
Range on Protein: 935-1184
Range on HMM: 23-275/288.0
LEQQYKNIIQFQPKDiHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
....|... ... ..     . . ||  |||   | |..  ||.|.  . |.|.||||||...| .. . .| || |.|.|..|||..|......|.| |
fseeynsLaalektk.svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

SSL---DDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQsiQDDYELTVKMLHCPSWPEMSNPNSIYDFI--VDVHERCNDYRNGPIVIVD
..|   .. .  ..|||. .| .  .  |. ... .. |.| | . ..  ..  ||... ..  .||... |.|  ...  ..  .  |.   |||... 
telveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC

RYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
  |  .. || |.  |  ..|   . .|    .   ..|. .    .    ||..|
saGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 935-1215 3.8e-32 106.5 In-house 26-307 (315) alignment 
Range on Protein: 935-1215
Range on HMM: 26-307/315.0
LEQQYKNIIQFQPKDIHIasAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
..|.|..|   | . ...  | |  |  |||   | . . |||.|     ...|||.||... |. . | .| .| | . ..||||..|....  ..|.|
fkqdyesipggqlhpldv..akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml

SSLD--DINFA-QFWPDEatPIESDHYRVKFLNKTNKSDYVSRDFviQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIvDVHERC---NDYRNGPIVIV
..|   . . | ..|||.   .   .. |   ..  ...|  | .    . .|   .|  ||  |||.|  |..   .. ... .    ..   |.||. 
tnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplm.nlirtvkqhhtnsvgaivvh

DRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL--SFLPGNLNLLKRTALRtEFEDVTTATPDLYS
 . |  .. ||......  ..|     .||.. .   ..| ..  . |  . ||..|  .|. |. .. ..  |  ... . . .||  |
csaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylq.rydsllapspdtgs
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 935-1148 1.1e-31 105.0 In-house 17-235 (281) alignment 
Range on Protein: 935-1148
Range on HMM: 17-235/281.0
LEQQYKNIIQFQPKDIHIASAmKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
. ..|... . . ..   ||  .. |  |||   |.  . .||..||.  .  .|||||... |..  ...|.|| |. .....||||||.......|..
fieeyeklaaigvdntatask.adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

SSL---DDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIqSIQDDYELTVKMLHCPSWPEMSNPNSIYD---FIVDVHERCNDYRNGPIVIV
      . .   ..|||... ..  ...||......|. |..| | . . ..  . .|. |.  .||.   |..  .   |  .|..  .  .. |.|| 
treieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvih

DRYGGAQACTFCAISSLAIEM
   |  .. |. |.  |. ..
CsaGvGrtGtyialDrlvkav
subfamily_PTPN9_pd Subfamily PTPN9 935-1114 1.9e-31 104.2 In-house 18-200 (297) alignment 
Range on Protein: 935-1114
Range on HMM: 18-200/297.0
LEQQYKNIIQFQPKDiHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
| ..|..| . ...   .  .....|. |||   .  .. .||.|. ..... ||||||... |... . || || |. .|..|||.|||.... ..|. 
lskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

SSLD---DINFAQFWP-DEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIvDVHE
  .     .  .|.|| .| . .|  ...|. ..  ...||. | ..|. .... . .|      |||.   |.|  ... || |
trvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaasll.dvle
subfamily_PTPN6_pd Subfamily PTPN6 935-1186 2.3e-31 103.9 In-house 28-295 (306) alignment 
Range on Protein: 935-1186
Range on HMM: 28-295/306.0
LEQQYKNIIQFQPKDIH-IASAMKQVNSIKNR-GAIFPIEGSRVHLTpKPGEDGSDYINASWLHGFR--RLRDFIVTQHPMAHTIKDFWQMVWDHNAQTV
.|...... | . |. .    . |. |  |||  .|.| . .|| |. .|.  |||||||. ...      . .| ||  . .|..|||.|||. |.. .
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

VLLSSLDDI---NFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQS-IQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCNDYR---
|..    .      |..|||| .  |  ...|. .......||. |.....   ... | .|  .|  |||. . |.    . ||. ||... .. .   
vmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

NGPIVIVDRYGGAQACTFCAISSLAIEMEYC---STANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSF
.||||.    |     ||  |  |   .|.       ....  |. .. | |.    .  . .|.....
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 935-1170 2.4e-30 100.5 In-house 22-260 (287) alignment 
Range on Protein: 935-1170
Range on HMM: 22-260/287.0
LEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGA-IFPIEGSRVHLTpkpgEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
 ..|.. . | . .. ..  .. . |  ||| . | . .  || |     .   |||||... |..  . ||... ||..|...||....|.| ...|.|
fknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivml

SS---LDDINFAQFWPDEATpIESDHYRVKFLNKTNKSDYVSRDFVIQSIQ-DDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCND-Y--RNGPIVI
.     |.    |.||.|.. .   .|....||.. ...|. |.. ..  . .. ...||  .  .|..  . ..    .. ..|.    .   |..||.
cqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivv

VDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGV
    .  .. .|||.     . .   . .|.|  |    ..|| 
hCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgs
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 935-1141 1.2e-14 48.6 In-house 13-220 (281) alignment 
Range on Protein: 935-1141
Range on HMM: 13-220/281.0
LEQQYKNIIQFQPKDIHIAsAMKQVNSIKNRGAIFP-IEGSRVHLTP-KPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVL
..|.. |.    | |.  .   . ||  ||| .  | .. |||.|    | .. .||| | ...     | .|.|| |   |  |||.|.|. |. ..|.
fkqefsnlpgdppsdlctv.fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LSSLDDIN---FAQFWPDEAT-PIESDHYRVKFLNKTNKSDYVSRDFVIqSIQDDYELTVKMLHcPSWPEMSNPNSIyDFIVDVHERCNdYRNGPIVIVD
|  . . |    |...| .|   .. |.. |.. . | .   |.  . . | . .  |  . |    ||.   |.|  . .. .  .    |  | ||  
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl.syegetrlithwlw.kewpdwqvpess.evmlkilrkir.arstppvihc

RYGGAQACTFCAI
  |  .. |. |.
sagvgrsgtlmav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 936-1184 1.3e-31 104.6 In-house 23-279 (290) alignment 
Range on Protein: 936-1184
Range on HMM: 23-279/290.0
EQQYKNIIQfQPKDIHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGE-D-GSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVL
..|.| . .   ..  .  .. . |. .|| | | . .  |. | |..|. |   .||||....|..  ...|.|| |. .|..|||...|...   .|.
rnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LSSLDD---INFAQFWPDEATPIeSDHYRVKFLNKTNKSDYVSRDFVIQSIQD-DYELTVKMLHCPSWPEMS---NPNSIYDFIVDVHERCNDYRNGPIV
| .  .    .  |.|||. |    .....| || .. ..|. | . ... .  ... .|. ..  .|..     ||..|   |  . .      |..||
ltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsiv

IVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
.    . ... .|||.      ..     .|.|  |    ..||  .. . ...|..|.
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 936-1180 2.7e-22 74.0 In-house 9-251 (267) alignment 
Range on Protein: 936-1180
Range on HMM: 9-251/267.0
EQQYKNIIQFQPKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEdgsdYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLS
|.....| .  ..   |.  . . |  .||     | . .|| |  |  |    |||||...|... . ||||| |.  || ||.... |..  ..||| 
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

SLDDINFAQFWPDE-ATPIESDHYRVKFLNKTNKSDYVSRDFVIQsIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERC-NDYRNGPIVIVDRYGG
     |  .||| . .   . .   |..  . .. ||    . .. ....    | . .   |   .| .     .. .  .   .  | |.|.    | 
kvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGv

AQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVI
 .. ||  | |    .   ........ .   ..|.|.  . |    |
GrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_PTPN13_pd Subfamily PTPN13 936-1181 1.3e-21 72.0 In-house 14-262 (273) alignment 
Range on Protein: 936-1181
Range on HMM: 14-262/273.0
EQQYKNIIQFQPKDiHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGedgsdYINASWLHGF--RRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVL
....|.. ...|.| .  .. |. |  |||   ..|.. .||.|  . |     |||||...        ..|..| |. .|.||||||||. .|. ...
aeefkelrelkpld.tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LSS---LDDINFAQFWPDEAT-PIE-SDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCN-DYRNGPIVI
...    . .   ..||...  ..  |. ..|. |. ......| |.. .. ..      |  |.  .||. . |.|  ...  | |  . .  .||||.
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivv

VDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIY
    |  .. |. .|  .   .|     .| .  .   ..| ||  ...    .|
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 937-1054 3.3e-17 56.9 In-house 75-186 (244) alignment 
Range on Protein: 937-1054
Range on HMM: 75-186/244.0
QQYKNIIQFQPKdiHIASAMKQVNSIKNR-GAIFPIEGSRVHLTpkPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSS
|  .|||. .|    .  |..  || ||| || .|.. .|| |.   |  |  |||||..  . |  ..|.||||.| |  |||.|. .   . .|.| |
qgsqniirpdps..vmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs

LDDINfaQFWPDEaTPIES
... .  ..|||   |.| 
veeed..eywpds.eplew
subfamily_CG7180_pd Subfamily CG7180 938-1185 1.8e-31 103.9 In-house 18-287 (296) alignment 
Range on Protein: 938-1185
Range on HMM: 18-287/296.0
QYKNIIQFQPKdIHI---ASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL
.|| ...  |. ..|   | .... |  |||   . | .  || |.   ||. ||||||..  .| . ...|||. |. .|...||..|.|.....|| |
eyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvL

SSLDDIN--FAQFWPDEAtPIESDHYRVKFLNKTNKSDYVSRDFVIQSI---------QDD-YELTVKMLHCPSWPE-MSNPNS---IYDFIVDVH---E
.   | .  . ..|| ..   .  .  |. ... . .. ..| | ..           | .  . .||...   |.   . | |   . ...  |.   |
tktfdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre

RC-NDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS
.  .|  .||.|.|   |.. .  ..||      .|     .|....|   ..||..  . |. . ||..|.
kvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_PTPN3_pd Subfamily PTPN3 938-1126 8.3e-25 82.2 In-house 20-213 (280) alignment 
Range on Protein: 938-1126
Range on HMM: 20-213/280.0
QYKNIIQFQpKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPgeDgsDYINASWL----HGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVL
|.... . . ....|  | |  |  |||   | | .  ||.|.  .     |||||...     .      .|.|| |.|.| .|||||||.......|.
qfeqlyrkk.pglaisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LSSLDD---INFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVhERCNDYR---NGPIVI
| .| .   .   |.||..   .|  ...||  .. ... || |..|..  . . | ..  |   .||. . |..  ||.  | || ...|   . |.|.
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv.ervrklrsgkeePvvv
subfamily_PTPN14_pd Subfamily PTPN14 938-1109 4.8e-21 70.0 In-house 28-206 (300) alignment 
Range on Protein: 938-1109
Range on HMM: 28-206/300.0
QYKNIIQFQPkDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEdGSDYINASWLHG--FRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLS
.| .| . .  | .. .|  ..|  |||   . | | .||.|.|   .  ..||||| ..     . |..||.| |. .|..|||||||... | .|.| 
eyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

SL---DDINFAQFWPDE---ATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFI
.          ...|..   .  .| ....|    ... . .. . . .. .    | || .|    ||.   |. . .|.
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 938-1142 1.3e-11 38.7 In-house 27-232 (303) alignment 
Range on Protein: 938-1142
Range on HMM: 27-232/303.0
QYKNIIQFQPKDIHIASAMKqvNSIKNRGA-IFPIEGSRVHLTpkpgedGSDYINASWLHgFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLssL
...... . | ..     .|  |  ||| . .  .. |.|.|.       | || ||.|. .   .  |.|| |..||  |||||. . . . |.||  |
efekvvsylppsvsknqfvk..nmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll..l

DDINFAQFWPDEATPIESDHYRV--KFLNKT-NKSDYVSRDFV---IQSIQDDYELTVKMLHCPSWPEMSNPNS----IYDFIVDVHERCNDYRNG-PIV
 | .. ..  |   | . |  .   ...     |   ..  .|   .   . ||   ... |  .||  | |.     .   | ..      | .. | |
tdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptv

IVDRYGGAQACTFCAIS
 .   |  .| ||. . 
ymslsgcgragtfalfe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 939-1045 4e-06 20.4 In-house 54-153 (349) alignment 
Range on Protein: 939-1045
Range on HMM: 54-153/349.0
YKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPiegsrvhltpkpGEDGSDYINASWLHG--FRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL
||.|. ..   . .  ..|  ..||.  .               .    ||||| .|.   .   . .| || |.  |..||....   . . |. |.. 
ykdilPyehsrvklkkslksskvikastsesd............sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

DDINFAQ---FW
.. .. .   .|
kelslekcdiyw
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 941-1044 9.6e-10 32.5 In-house 20-128 (347) alignment 
Range on Protein: 941-1044
Range on HMM: 20-128/347.0
NIIQFQPKDIHIASAMKQVNSIKNRGAiFPIEGSRVHLTPKP-----GEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHN-AQTVVLLS
|. .. | ..  .   |...  . .     |. .|| |.|.       .|   ||||| ..     ...|.||.|. .|..|||.||   . .| | .. 
nlanyspskftsvewekslsknrskdv.klidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

SLDDINFAQF
   |    .|
pikdeaieef
subfamily_PTPN1_pd Subfamily PTPN1 943-1178 2.3e-27 90.5 In-house 15-261 (290) alignment 
Range on Protein: 943-1178
Range on HMM: 15-261/290.0
IQFQPKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGedgsDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL---DD
|. . .|.....| .. |  .||   . | . ||..|  .      |||||| ..  .  | .|.|| |...|.. ||||||......||.|  .   . 
irkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

INFAQFWP--DE--ATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSN---PNSIYDFIVDVHER-CNDYRNGPIVIVDRY
|  ||.||  .|  .  .|  ...||.... .|| |. | . .. .. .   ..   |  .||...    |..  .|. .| |  .     || ||    
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GGAQACTFCAISSLAIEMEYCSTAN---VYQYAKLYHNKRPGVWTSSEDIR
|  .. ||| . .. ...|    ..   . .      . | |.    . .|
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 943-1182 4.6e-25 83.1 In-house 18-260 (283) alignment 
Range on Protein: 943-1182
Range on HMM: 18-260/283.0
IQFQPKDIHIASAMKQVNSiKNRGAIFPIEGSRVHLTPKPGedgsDYINASWLH---GFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLD--
.   ..|  |||| .. .  .    | | .  ||.| ...     |||||...      .. ...|..| |. .|..|||.||.|... ..|.|. |   
lsvpdldadiasadenkrk.nrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

-DINFAQFWPDEATpIESDHYRVKFLNKTNKSDYVSRDFVIQSI-QDDYELTVKMLHCPSWPEMSNPNSIYDF--IVDVHERCNDYRNGPIVIVDRYGGA
 .|. .|.|| . . ..   . |   . | .  .. . ....       .| .       | |...   |  .  .  |    .. ..||||.    |. 
lrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiG

QACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYN
.. .|.|.|.   ..   |  .|..  |   ..|...  . .  .....
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhe
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 944-1184 8.3e-33 108.9 In-house 30-284 (325) alignment 
Range on Protein: 944-1184
Range on HMM: 30-284/325.0
QFQPKDIHI--ASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD--
.. | |  |    |||  |  |||   . ... ||| |  |  .  |||||||.|. ...   |. .| |...||.|.|..| | ..  ||.|  ||   
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk

INFAQFWPDE-ATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN------SIYDFIVDVHERCND--YRNGPIVIVDR
 . |..||.| .   .    .||.    . |||| | . .. ...   ..|| ..  ||..| ...      || . .  |.|| .      .||..   
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

YGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
 |  .. .| .. |.. ..   |  ..... |   ..|| .  . .   .||. |
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 945-1185 8.2e-30 98.8 In-house 18-265 (274) alignment 
Range on Protein: 945-1185
Range on HMM: 18-265/274.0
FQPKDIHIASamkqvNSIKNR-GAIFPIEGSRVHLTPKPGEDG-SDYINASWLHGFRRL-RDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINF
|........      .. |||  .|.| | ||| |... .||  |.|||| ...|...  . .. || |...|..|||.|.. ...| .|.|  | . | 
fdqeeldvfg.....sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

---AQFWPDEATP-IESDHYR--VKFLNKTNKSDYVSRDFVIQSIQDdyELTVKMLHCPSWPEMSNPNS---IYDFIVDVHERCN--DYRNGPIVIVDRY
   |...||.    |.  .    .|. ..... ||  | .|... ..  | .||    ..||..  |..   . |.. .|.|  .  . . .|.|.    
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa

GGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS
|  ..  | |||    ...  .. .| .       .| |.  .||  ..|...|.
GiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 946-1184 9.1e-32 105.1 In-house 30-273 (315) alignment 
Range on Protein: 946-1184
Range on HMM: 30-273/315.0
QPKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL---DDINF
.|.  .  .| ...|  ||| . |.|.. .|| |     .  ||||||| ....   . .| .| |   ...|||.||..... |.|... .   | |. 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

AQFWPD-EATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDdYeLTVKMLHCPSWPEMSNPN---SIYDFIVDVHERcNDYRNGPIVIVDRYGGAQACT
.|.||| .|  .|   ..|. |.    .| | | .|..  .. .  ||   .   ||.   ..   |.  .| .|    |. .. ....    |  ..  
rqywPdrkadsvefGsikvellsleadtdgvarklvtrksee.s.rtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGv

FCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
...| .   ...  .. .|... |   .||| .  . |.   ||...
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 947-1183 1.8e-22 74.3 In-house 32-231 (392) alignment 
Range on Protein: 947-1183
Range on HMM: 32-231/392.0
PKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINfaqfw
|.  . ..| |..|  ||| . |.|.. .||.|        |||.|||....|   . .| .| | | ...|||.||...|. |..... |.. .     
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

pdeatpiesdhyrvkflnktnksdyvsrdfviqsiQDDYELTVKMLHCPSWPEMS---NPNSIYDFIVDVHERCNDYRNgPIVIVDRYGGAQACTFCAIS
                                   . |   ||   |   ||.       .|.  || .|.    .|   |..|    | ...    .| 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth.pliihcsagvgrtgvvisid

SLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI
|.    .     .|...    ..||| .  . |.  .||  
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyga
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 948-1181 6.1e-34 112.8 In-house 13-248 (284) alignment 
Range on Protein: 948-1181
Range on HMM: 13-248/284.0
KDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSsldDINFAQFWP
.    . |  . |  ||| | |.. . ..| | .  ||..|||||||.. |..|   .| || |.  |..|||.|.|..|. |.|||.   . . .|.||
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywp

DEATpIESDHYRVKFLNKTNKSDYVSRDFVIQS-IQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHE----RCNDYRNGPIVIVDRYGGAQACTFCAI
 ..  |. ....||    .. ..|| ||. .    .     ...  |   ||..  |..  |..  |.     .     . .||.    |  .. .. ..
lkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

SSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIY
  |   |.  .  .||.. .   ..|. .  .  .   ||
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiy
subfamily_egg_pd Subfamily egg 949-1141 4.5e-15 50.1 In-house 29-221 (307) alignment 
Range on Protein: 949-1141
Range on HMM: 29-221/307.0
DIHIASAMKQVNSIKNRGAIFPI-EGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQ-FWP
.| .  |... |  | |    .  . |||.|  . |    |.| |  ..|   | .||..| |.  | .|||.||.  . | .|.|.|  . .  . .||
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywp

D-EATPIES--DHYRVKFLNKTNKSDYVSRDFVIQSIQDDyeltVKMLHCPSWPEMS-NPNSIYdFIVDVHERCNDyRNGPIVIVDRYGGAQACTFCAI
  |. ..      .|.. |.  .|.| . |   .. .  |     . ..   |     | . .| . . |  .  .    |.|. |  | ..|.|. ||
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd....deerflehwqgdvnnssdvy.splrvlrklrn.lskpvvvqdilGvskaatlvai
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 949-1048 2.6e-12 41.1 In-house 38-153 (350) alignment 
Range on Protein: 949-1048
Range on HMM: 38-153/350.0
DIHIASAMKQvnSIKNR-GAIFPIEGSRVHLT--PKP------GEDGSDYINASWLHGF----RRLRDF--IVTQHPMAHTIKDFWQMVWDHNAQTVVLL
|. ... ..     |||   |.| | |||.|   .|.         ..|||||..|.      .   ||  | || |.  |..||....   . . .. |
DvilseGvel..faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

SSLDDINFA---QFWPDE
.|... |     ..|.. 
tsdvelnlekcyrYWqeg
subfamily_PTPN12_pd Subfamily PTPN12 951-1183 1.4e-28 94.7 In-house 31-272 (290) alignment 
Range on Protein: 951-1183
Range on HMM: 31-272/290.0
HIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSS---LDDINFAQFWP
  ... |..|  |||   |.| . |||.|. . .|.|||||||....|      .| .| |...|..|||.|.|..| . ||..     |. .  ...||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DE-ATPIESDHYRVKFLNKTNKS-DYVSRDFVIQSIqdDYELTVKMLHCPSWPEMSNPNSIYDFI--VDVHERCNDYRNGPIVIVDRYGGAQACTFCAIS
.|  ...| ....|.  .. . . |.. | . ..    . . .|. .|  .||.   |.|. . .  ..  .. ..  . |.|.    |  .. | .|| 
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

SLAIEMEYC---STANVYQYAKLYHNKRPGVWTSSEDIRVIYNI
     ..     .. .|..      ..|. .  . |  ...|. 
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyka
subfamily_PTPRA_pd Subfamily PTPRA 952-1190 4.5e-42 139.1 In-house 50-299 (330) alignment 
Range on Protein: 952-1190
Range on HMM: 50-299/330.0
IASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPD
.  | |. |  |||   |.| . |||.|..| |.. |||||||...|...   || .| | ..|..|||.|.|.....|.|.|. |..      ||.|||
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

EATpIESDHYRVKFLNKTNKSDYVSRDFVIQSIQD----DYELTVKMLHCPSWPEMS---NPNSIYDFIVDVHErCNDYRNGPIVIVDRYGGAQACTFCA
| . .   . ||.  ..|   ||  |.|..| . |    . .  |. .|  |||..    .|  . ...  |.. .|.   ||||.    |  .. ||..
eGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk.lnqqsagpivvhcsaGvGrtGtfiv

ISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS-F-LPGN
....   ..     .|..  |   ..|| .  . |    ||..|  . | |.
ldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd
subfamily_PTPRK_pd Subfamily PTPRK 953-1184 5e-40 132.3 In-house 36-273 (314) alignment 
Range on Protein: 953-1184
Range on HMM: 36-273/314.0
ASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDIN---FAQFWPDE
 .| |. |  ||| | | . . ||| |..  |.  ||||||... ...| . |||||.|. .|.||||..|.|.|. ..|.|. | .       ..||..
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

ATPieSDHYRVKFLNKTNKSDYVSRDFVIQSIQDDY--ELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCNDyRNGPIVIVDRYGGAQACTFCAISS
..    .. .|.... . ....|.| | .. ..  .    .|. ..  .||.   |.   .. ...  |..  .. ..|.||.    |. .. ||.||..
tev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidi

LAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
.   .|  .. .|.. .|   .... .    |  . ||...
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 953-1184 6.1e-32 105.9 In-house 44-280 (297) alignment 
Range on Protein: 953-1184
Range on HMM: 44-280/297.0
ASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRlrDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDIN--FAQFWPDEA
  | |.||  |.|   | |.. |||.|     .  |||.|||...|..    .| || ||  |..|||.||.|....|.|.|. ... .   |..|.|..
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg

TPIeSDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN-----SIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSL
.     .  |. |  .... .. |.....  .   .  ||  .  .||. . ..     |. ..| .|..  ..  .||...    |  ..  ...| | 
vtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

AIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
  |..   . ..... |   ..|| .    |. . .|...
vaeakrekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 953-1102 4.3e-09 30.5 In-house 48-204 (305) alignment 
Range on Protein: 953-1102
Range on HMM: 48-204/305.0
ASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGedGSDYINASWLHG-FRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSS---LDDINFAQFWPDE
|    ...  ||| .  | .   . .  ||    |||| | ..   .   . ||..| |. .|| .|| || ... . .|.|     |  .. ||.||  
anqsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

ATPiESDHYRVKFLNKTNKSDYVSRDFVIQS--IQ----DDYELTVKMLHCPSWPEMSNP
      .      ...   |  . ||  ||   ..     | ...|. |.   ||.   |
qge.klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp
0037934 (Phosphotyrosine protein) phosphatases II 954-1185 3.1e-42 140.2 In-house 4-239 (243) alignment 
Range on Protein: 954-1185
Range on HMM: 4-239/243.0
SAMKQVNSIKNRGA-IFPIEGSRVHLtpkpgeDGSDYINASWLHGFRRlrdFIVTQHPMAHTIKD----FWQMVWDHNAQTVVLLSSLD---DINFAQFW
 |....|  |||   |.| . |||.|      .|||||||..  ...|   .|.||.|. .|..|    ||.|.|... ...| | .|.    .. ||.|
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PDEAtpiESDHYRVKFLNKTNKSDYVSRDFVIQSIQ-DDYELTVKMLHCPSWPEM---SNPNSIYDFIVDVHERCND-------YRNGPIVIVDRYGGAQ
|.|    . ....|..|. ....||. | .... .. ||....|  .|. .||..   ..|....||. .|.| ...        ..||...  . |   
pgev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

ACTFCAISSLAIEMeycsTANVYQYAKLYHNKRPG-VWTSSEDIRVIYNILS
. |..|.  .   .    . ..... ||. ..||| .... . .| .| .| 
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 954-1184 3.1e-29 96.4 In-house 37-272 (515) alignment 
Range on Protein: 954-1184
Range on HMM: 37-272/515.0
SAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL---DDINFAQFWPD-E
 | ...|  ||| . |.|.. .|| |     .  |||.||| ...|   . .| .| |   ...|||..|...|  |..... |   | |. ...|||  
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

ATPIESDHYRVKFLNKTNKSDYVSRDFVIqsIQDDYELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDYRnGPIVIVDRYGGAQACTFCAISSLA
.  ..  ...|. .     .. . | . .  ...|   ||   |   ||.   |   .|.  .| .|    . |   |..|    |  ..  ...| |  
gdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvv

IEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
 ...   . .|... .   .||| .    |.   ||...
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 954-1181 1.6e-28 94.4 In-house 32-270 (287) alignment 
Range on Protein: 954-1181
Range on HMM: 32-270/287.0
SAMKQVNSIKNR-GAIFPIEGSRVHLTpKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL-SSLDDINFA--QFWPDEA
.| .  .  ||| . ..||. .|| |. . || ||||||| .. ....   ||..| |.| |..|||..|..... .|...   ...      ..||.  
aaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

TPIESDHYRVKFLNKTNKS-DYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNS---IYDFIVDVHERCND----YRNGPIVIVDRYGGAQACTFCAI
 |.    | |  |....|. .|  | . .  ..      || |.  |||. . . .   .  |..||... .        ||.|. |  |  .. .. |.
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

SSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIY
  |   .|     .| .      ..| ..  .   .|..|
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrlly
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 954-1180 5.3e-19 63.3 In-house 2-233 (239) alignment 
Range on Protein: 954-1180
Range on HMM: 2-233/239.0
SAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRR-LRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDE
.| |.||  ||| | |   . ||| |     .  |||||||.|. .    . .| ||  .. .  |||.|.|.     .|.|. | .    .  |.||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

ATpiESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNG--PIVIVDRYGGAQACTFCAISSLAI
..  .    || . .    .||. | ||.  . .  |  |   |   ||.   |.     .   ..  .|   |  | ||    |  .. .|  | ..  
ts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

EMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVI
. .   | ....| |  .. || .  .||.  .|
qakkqktvdifnyvkairedrphmvqtseqyvfi
0040439 (Phosphotyrosine protein) phosphatases II 955-1186 5.2e-51 169.0 In-house 6-244 (249) alignment 
Range on Protein: 955-1186
Range on HMM: 6-244/249.0
AMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDeAT
|....|  |||   |.| . |||.|.. ||  .|||||||...|... |.||.||.|. .|..|||.|.|... ...| |.||.    ...||.||.  .
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.gg

PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMS---NPNSIYDFIVDVHERCNDY-RNGPIVIVDRYGGAQACTFCAISSLAI
..| ....|..|. . |.||. | . .. ..|. ..||. .....||...   ..... |||  |.. .... ..||...    |   ..||.|.  .  
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

EMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSF
 .|.  . ..... ||. ..|||. .. | .| .|..| .
qlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 955-1185 4.5e-50 165.7 In-house 4-240 (245) alignment 
Range on Protein: 955-1185
Range on HMM: 4-240/245.0
AMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWPDeAT
|....|  |||   |.| . .||.|.| .|. .|||||||. .|.|. . ||.||.|...|..|||.|.|... .|.| |.....    ..||.||.  .
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIE
... ....|..|. ....||. | . .. ..||....|  .|. .||... |.   .. ||.  |.. ... .|||...  . |   ..||.|.  ..  
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

MEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILS
.|.  . ....  | . ..|||. .. . .| .| .| 
lekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 955-1184 4.9e-45 148.7 In-house 4-238 (250) alignment 
Range on Protein: 955-1184
Range on HMM: 4-238/250.0
AMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI--NFAQFWPDEATP
| |  |  ||| | | ... ||| | .. |.. |||||||.|||..  . ||.||.|. .||.|||.||......|.|.|..| .   .. |.|| | . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

iESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEM
 .  . .|. |.| ...||..| ... . .   | .|. ||  .||. . |.   .. ... .|.   .   |.|...    | ... .|.||...   .
.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

EYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
.   . .|... |   ..||.. .| |    .|.|.
kkekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 955-1180 6.6e-19 63.0 In-house 2-232 (239) alignment 
Range on Protein: 955-1180
Range on HMM: 2-232/239.0
AMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRR-LRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDEA
| |.||  ||| | |   . ||| |     .  |||||||.|. .    . .| ||  .. .  |||.|.|.     .|.|. | .    .  |.||| .
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

TpiESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNG--PIVIVDRYGGAQACTFCAISSLAIE
.  .    || . .    .||. | ||.  . .  |  |   |   ||.   |.     .   ..  .|   |  | ||    |  .. .|  | ..  .
s..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

MEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVI
 .   | ....| |  .. || .  .||.  .|
akkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_CG42327_pd Subfamily CG42327 955-1109 4.4e-13 43.6 In-house 27-187 (319) alignment 
Range on Protein: 955-1109
Range on HMM: 27-187/319.0
AMKQVNSIKNRgaiFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLR-DFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDIN---FAQFWPDEAT
. |. . . |     |.  .|| |  .. .| . |..||.. |..  .  .| .| ..  .  |||..||. .....| |..| .      |...| ..|
tskdksrvinv...vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

PIESDH---YRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCpSWPEMSNPNS---IYDFI
  . .    ..| . ..  |  |.   .... ....    .       |.|   | .   .   .
ldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 955-1108 2.5e-11 38.0 In-house 28-186 (297) alignment 
Range on Protein: 955-1108
Range on HMM: 28-186/297.0
AMKQVNSIKNRG-AIFPIEGSRVHLTPKPgeDGSDYINASWLHGFRRLR--DFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWPDE
| ..    |||   |.  . .||.|   .   ..||||| ..          .|..| |.  |..|||..|.... ...|... | .      | .||. 
akrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

A-TPIESDHYRVKFLNKTNKSdYvSRD--FVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDF
     .. .. |.|| .|    .  |     .| |  . .  |.     |||.   |. . | 
vqerlkagdvvveflsstsde.f.drviltelqliyrsesrvvrhvqflswpdhGvpsdledl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 955-1133 8.1e-10 32.7 In-house 48-235 (310) alignment 
Range on Protein: 955-1133
Range on HMM: 48-235/310.0
AMKQvNSIKNR-GAIFPIEGSRVHLTPKPGEDgSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQ---FWPDEAT
|.|. .  |||   .   . |||.|.        ||| | ...       ||..| |. ||| |||.|...  |....||    .    .   .||    
aykk.ymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

PIESDHYRVKFLNKTNKSDY---VSRDFVIQSIQDD------YELTVKMLHCPSWPEMSNPNSIYDFIVdvHERCNDYRNGPIVIVDRYGGA
       ||  |... .      ..  || . .  |       || |.... | ||..  |.     .        . | || |.    |  
tetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqvrhgpcvvhcsagkd
subfamily_ptpA1_pd Subfamily ptpA1 956-1048 1.9e-15 51.5 In-house 43-138 (418) alignment 
Range on Protein: 956-1048
Range on HMM: 43-138/418.0
MKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRrLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDE
 |. |. |||   |.|.. .||.|     ..||||||| .. |    ..||.|| |.  || |||.|||.  .. .|.||   .   |.  ..||..
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 957-1099 6e-08 25.8 In-house 24-152 (169) alignment 
Range on Protein: 957-1099
Range on HMM: 24-152/169.0
KQVNSIKNRGAIfPI--EGSRVHLTPKPGEDGSDYINAswlhgfrrlrdfivtqhpmahtikdfwQMVWDHNAQTVVLLSSLDDINfaQFWPDEA-----
  .|  ||| |  |.     ||.|     . |||||||                           .|.|. ||  .|.|   || |  .|||.       
ltcnetknrpag.plapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn..nfwpekedyqlh

-TPIESDHYRVKFLNKTNKSDYVSRD--------FVIQSIQDDYELTVKMLHCPSWPEM
 . |  . |   .  .|.| .  ..         .||.| .||    ...||  .||. 
pavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 957-1049 1e-07 25.0 In-house 23-87 (169) alignment 
Range on Protein: 957-1049
Range on HMM: 23-87/169.0
KQVNSIKNRGAIfPI--EGSRVHLTPKPGEDGSDYINAswlhgfrrlrdfivtqhpmahtikdfwQMVWDHNAQTVVLLSSLDDINfaQFWPDEA
  .|  ||| |  |.     ||.|     . |||||||                           .|.|. ||  .|.|   || |  .|||.  
ltcnetknrpag.plapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn..nfwpeke
0049772 (Phosphotyrosine protein) phosphatases II 959-1176 7.6e-25 83.7 In-house 45-268 (314) alignment 
Range on Protein: 959-1176
Range on HMM: 45-268/314.0
VNSIKNRGA-IFPIEgSRVHLtPKPGEDGSDYINASWLHGFrrlRDFIVTQHPMAHTIKDF----------WQMV--WDHNAQTVVL-------------
.|  |||   |.| . .||.| |. . .||||||||...||   ..||.||.|. .|. ||          |.||  .|.|  ..|              
lnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LSSLDDINfaqfwpDEATPIESDHYRvkflnktnksdyvsrdfviqSIQ---DDYELTVKMLHCPSWPEMSNPnsIYDFIVDVHERCNDY-R
        | .||  .      .| |. . ....                    ...   ...| ..  ...  .|  | |  . ... .. | .... .
daAlgKtpllildgng......neptaadlellk....................eelydpelferlgikylripvpDgsap..lledfdeflefieeadk

NGPIVIVDRYGGAQACTFCAISSLAIEMEYcstaNVYQYAKLYHNKRP-----GVWTSSED
.||...  . |   ..||...  | . . .    .. .  . ...|||     | . . |.
ggpvlvHCkaGkgRtgtfvvaaylmkllgv....sleealedvrlkRpinpnpgfieqleq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 960-1178 2.9e-21 70.8 In-house 3-229 (237) alignment 
Range on Protein: 960-1178
Range on HMM: 3-229/237.0
NSIKNR-GAIFPIEGSRVHLTPKPGEdgSDYINASWLHGFRR-LRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWPDEATPIES
| |||| | |   . ||| |    ..  ||||||..|.||    . .| .| |.  . .|||||||. .   .|.|. | .       ..||.   |   
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

DHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELT-VKMLHCPSWPEMSNPN---SIYDFIVDVHERCND-YRNGPIVIVDRYGGAQACTFCAISSLAIEME
  . | .  | . |||  | ....  .   |.  ..  .  |||.   |.   ..  |  .. .| .   . || .|    | ...  |  | ..  . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YCSTANVYQYAKLYHNKRPGVWTSSEDIR
     ..|.| .   . || .  . ..  
ekkvvdiynyvysieedrpyiiqtkdqyv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 960-1141 4.5e-06 21.0 In-house 19-211 (290) alignment 
Range on Protein: 960-1141
Range on HMM: 19-211/290.0
NSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRdFIVTQHPMAHT-------IKDFWQMVWDHNAQTVVLLSSLDDIN-------FAQFW
.....| ..  .| .|| |        .||| |. .     || .|.|| | ...       |..|| |. . ... || |   .. .        |.. 
hemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PDEAT-PIESDHYRVKFLNKTNKSDYVSRDFVIQsIQDDYELTVKMLHCPSWPEMSNPNSIYDfIVDVHERCNdYRNGPIVIVDRYGGAQACTFCAI
|...   .  .   ||  .| .. |   |  |..  .|. |.||.     .| ... ...    .... .  .  .. |... .  |  .  .. ||
pesvgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtkt.llsliqkvk.asktpvivHcvdGiSrsAalaai
Y_phosphatase Protein-tyrosine phosphatase 961-1184 1.7e-48 160.5 Pfam-A 2-233 (235) alignment 
Range on Protein: 961-1184
Range on HMM: 2-233/235.0
SIKNR-GAIFPIEGSRVHLtpKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWP-DEATPIESD
. |||   | |.. .||.|  |  |. ||||||....|... . ||.||.|. .||.|||.|||... ...|.| ||..    ..||.|| .| .. . .
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

HYRVKFL-NKT-NKSDYVSRDFVIQSIQDD-YELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCnDYRNGPIVIVDRYGGAQACTFCAISSLAIEME
...|.   ... ....|. |.. ... ...  . .||.||. .||. . |   .|. |.| .|...  . ..||.|..   |  ...||.|.. |  ..|
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqle

YCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
  .. .|.|. |   ..|||. .| |   ..|...
aeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 961-1184 1.7e-48 160.5 In-house 2-233 (235) alignment 
Range on Protein: 961-1184
Range on HMM: 2-233/235.0
SIKNR-GAIFPIEGSRVHLtpKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWP-DEATPIESD
. |||   | |.. .||.|  |  |. ||||||....|... . ||.||.|. .||.|||.|||... ...|.| ||..    ..||.|| .| .. . .
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

HYRVKFL-NKT-NKSDYVSRDFVIQSIQDD-YELTVKMLHCPSWPEMSNP---NSIYDFIVDVHERCnDYRNGPIVIVDRYGGAQACTFCAISSLAIEME
...|.   ... ....|. |.. ... ...  . .||.||. .||. . |   .|. |.| .|...  . ..||.|..   |  ...||.|.. |  ..|
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqle

YCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL
  .. .|.|. |   ..|||. .| |   ..|...
aeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 961-1148 5.8e-10 33.7 In-house 44-230 (288) alignment 
Range on Protein: 961-1148
Range on HMM: 44-230/288.0
SIKNRG-AIFPIEGSRVHLTpkpgEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWPDEATpiesDH
. ..|   ..  . .||.|.    .|   ||.|  .   .  | .| .| |.  ||. .|.|. . . . .|.|. | .    . |...| .      ..
ptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG....ek

YRVKFLNKTNKSDYVSRD--FVI----QSIQDDYELTVKMLHCPSWPEMSNPNSiYDFIVDVHERCNDYrNGPIVIVDRYGGAQACTFcAISSLAIEM
 |.. | .  | ...  |   ..     | . . .  ||.||   |.. . |.. |   . . |. ... . |||.  . |  .. |. ... .|.|.
arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen.ylsplrllevlksl.qkPivvhssaGvGrtgtl.ililiales
subfamily_eak_pd Subfamily eak 963-1102 2.6e-07 24.3 In-house 55-195 (332) alignment 
Range on Protein: 963-1102
Range on HMM: 55-195/332.0
KNRGAIFPIEGSRVHLTPKPgEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDI---NFAQFWPDEA-TPIESDHYR
.|   | | .   |.||.    .   ||||| .      | .|.|  .    .  ||||| . .. ..| |    .    .. ...||..   ..  .. 
rnvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VKFLNKTNKSDYVSRDFVIQSIQDDYEltVKMLHCPSWPEMSNP
|.  .  ... .  | ....   . ..  |.  .   | |.. |
verkefvkrniletrllelskGnethr..vlhykvfGwtettlp
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 966-1183 2.3e-18 61.1 In-house 27-259 (270) alignment 
Range on Protein: 966-1183
Range on HMM: 27-259/270.0
GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFR-RLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDIN---FAQFWPDEATP---IESDHYR
  | |   .|| | .   .. . |||| ...||  . . .| .. |.. |.|.||.|.|.......|... | . .    ...|| |.     .|  . .
adiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkik

VKFLNKTNKSDYVSRDFVIQsIQDDYELTVkMLHCPSWPEMSN---------PNSIYDFIVDVHERCNDYRNG-PIVIVDRYGGAQACTFCAISSLAIEM
|  |...... |. .   ..  . . .  |   .  .||. .          ....   . .|.. ... ... |... .  |   . |. |.      .
vlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlL

EYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI
|  . ..| .  .   ..|. .   .| .. .|. 
eetkkvdvlaiieelRkdRmalvqhpeqyeflyka
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 967-1038 7.2e-08 26.3 In-house 42-112 (332) alignment 
Range on Protein: 967-1038
Range on HMM: 42-112/332.0
AIFPIEGSRVHLTPKPGEDgsDYINASWLHGFRRLRDFIVTQHPMA-HTIKDFWQMVWDHNAQTVVLLSSLDD
 .. .. ||| |.|. |.|  |. ||||. |. .   .|..| |.  ||   ||.|| ...   ....  .|.
hlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 968-1037 7.3e-07 23.4 In-house 44-110 (285) alignment 
Range on Protein: 968-1037
Range on HMM: 44-110/285.0
IFPIEGSRVHLTpkpgEDGSDYINASWLHGF-RRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLD
.  || .|| |     .   ||| |||..   .    .| || |.  |. |||.|... .   |..| .| 
vrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlf
0044763 (Phosphotyrosine protein) phosphatases II 970-1188 2.5e-19 65.0 In-house 1-171 (178) alignment 
Range on Protein: 970-1188
Range on HMM: 1-171/178.0
PIEGSRVHLTPKPGEDGSDYINASWLHGFrrlrdFIVTQHPMahtiKDFWQMVWDHNAQTVVLLSSLDDINF---AQFWPDEATpiesdhyrvkflnktn
|....||.|.. .|. .|||||||.  ..     ......|.     |......... ...| |.. .  .|    . ||.||                 
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

ksdyvsrdfviqsiqddyeltVKMLHCpSWPEMSNPN--SIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEmeycsTANVYQYAKLYH
                     ...||.  .| ...|.  .. . .|.  |.. | ..||...  ..|   ..|..|.  .          ....  .|..
.....................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

NKRPgVWTSSEDIRVIYNILSFLP
..|| .... ...| .| . ..| 
erRp.ivpnpgqlrqLyefelrll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 970-1036 7.7e-06 19.8 In-house 59-122 (305) alignment 
Range on Protein: 970-1036
Range on HMM: 59-122/305.0
PIEGSRVHLTPKpgeDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL
 ..  ||.| .       .|| | ..      . || || |. .|  ||| | .... ... .|  |
cldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnl
0041856 (Phosphotyrosine protein) phosphatases II 974-1184 1e-25 85.8 In-house 16-167 (182) alignment 
Range on Protein: 974-1184
Range on HMM: 16-167/182.0
SRvhltpkpgedGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSslddinFAQFWPdeatpiesdhyrvkflnktnksdyvsr
||          ..|||||... | .. ..||.||.|. .|. ||..|..... .|.| |.        . ||                           
sr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp...........................

dfviqsiqDDYELTVKMLHCPSWPEMSNPNsiYDFIVDVHERCNDyRNGPIVIVDRYGGAQACTFCAISslaiEMEYCsTANVYQYAKLYHNKRPGVWTS
        ...| ..  ... .|| .. |.   | ..|  |.... ..||...  ..|   ..|..|.      |...   ....  ||. ..|||....
........ellerlgiqylylpwpDhgvpd..ldelldfieevle.eggpvlVHCsaGvgRtgtlvaay....lmkkl.gvsleeavklvrsrRpgmvit

SEDIRVIYNIL
 . ..... .|
pnqyfflqlal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 974-1143 5.3e-12 40.0 In-house 71-238 (290) alignment 
Range on Protein: 974-1143
Range on HMM: 71-238/290.0
SRVHLtpKPGEDGsDYINASWLHGFRRLrdFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL-DD--INFAQFWPDEATP-IESDHYRVKFLNKTNKS-
.|| |  | | || ||. | ...| .    ||.|| ... |. |.|.|| .... ..|.|  | .|     .|..|...   .   .. |   ....|  
trvil..kdGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkda

DYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVheRCNDYRNGPIVIVDRYGGAQACTFCAISS
. . . . ..  ..  |  .| |.  |||. | ..|   ..  .  |     .||.|.    |  .. || ||  
niikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtl..rilrkasGpvvvhcsaGiGrtGtfvaiev
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 977-1098 2.8e-11 37.9 In-house 11-123 (130) alignment 
Range on Protein: 977-1098
Range on HMM: 11-123/130.0
HltpkpgedGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINfaQFWPDeATPIESDHYRVK-FLNKTNKSDYVSRDF
.        | .|||||..    | .... ||||.| |  |||.|. .     .|.| |... .  ..||| . |.|    ..   | . ......  ..
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed..eywpd.sePlewyeediivtltdrdefknikasn

ViQSIQDDYE--LTVKMLHCPSWPE
. .  .|  |   .. |..   || 
l.eiesdlneshqaltmfqisnwps
0046846 (Phosphotyrosine protein) phosphatases II 980-1184 6.6e-17 57.3 In-house 5-169 (176) alignment 
Range on Protein: 980-1184
Range on HMM: 5-169/176.0
PKPGEDGSDYINASWLHGFRrlrdFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINF---AQFWPDeatPIESDHyrvkflnktnksdyvsrdfv
.   . ..|||||... | |    .|.||.|. .|. ||..|..... ..|| | .. ....   ...||.     . ..                    
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi....................

iqsiqddyeltvkMLHCPSWPEMSNPNSiyDFIVDVHERCNDYR--NGPIVIVDRYGGAQACTFCAISslaiEMEYCSTANVYQYAKLYHNKRP-GVWTS
               ..  ||... |..  . . .. | .....  .||...  . |   ..|..|.      .|.    .|..  .|. ..|| |. ..
.............qylhlpwpDhgvpdl..elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

SEDIRVIYNIL
 | .| .|  .
peQyrflyefe
0043147 (Phosphotyrosine protein) phosphatases II 984-1181 6e-22 73.6 In-house 2-154 (172) alignment 
Range on Protein: 984-1181
Range on HMM: 2-154/172.0
EDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLddinfaqfwpdeatpiesdhyrvkflnktnksdyvsrdfviQSIQDD
..||||||||.|.. .  ..||.|| |. .|. |||.|..... ...| | .|                                         . . ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpel

YELTVKMLHCPSWPEMSNPnS---IYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAiemE-YcstaNVYQYAKLYHNKRPGVWTSSEDIRV
.| ..  ... .|| .. | .   ...|.  ..|... ...||...  ..|   ..|..|.  .    . .    ....  .|. .||||.... . .| 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lgl....sleeavalvrekRpgavqnpsqyrf

IY
.|
ly
0036282 (Phosphotyrosine protein) phosphatases II 986-1182 6.2e-25 83.3 In-house 1-164 (174) alignment 
Range on Protein: 986-1182
Range on HMM: 1-164/174.0
GSDYINASWLHGFRRLRDFIVTQHPMAhtikdFWQMVWDHNAQTVVLLSSLDDIN---FAQFWPDeatpiesdhyrvkflnktnksdyvsrdfviqsIQD
||||||||.|....... .|..|.|.|     ||.|..... .||| | ..   .   . ..||.                                 ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

DYELTVKMLHCPSWPEMSNPNS--IYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEyCSTANVYQYAKLYHNKRPGVWTSSEDIRVI
|.| ..  ...  || .. |..  ...|.  |.| ... ..||...  . |   . |..|.  .   ..  |. ..... .  ...|||.... . .| .
dlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YN
| 
yy
0051429 (Phosphotyrosine protein) phosphatases II 986-1184 1.2e-20 69.8 In-house 3-221 (272) alignment 
Range on Protein: 986-1184
Range on HMM: 3-221/272.0
GSDYINASWLHGFRR---LRDFIVTQHPMAHTIKDFWQMvWDHNAQTVVLLSSLDDINF---AQFWP-----------DEATPIESDHYRVKFLNKTNKS
 |.||||... |. |    . .. ...|. .|..|||.. ....  |.| | |.. ...    ..||           |.|..|.  ..||..| .....
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYVSRDFVIQSI-QDDYELTVKMLHCPSWPEMSNPNSIydfIVDVHERCNDyrNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTAN--------VYQY
||. | ...  . . .  ..| .||. .|| .. | .    .... | ..|  .||...  . |     |..|.  |.  ...   ..        ....
dyilrellltlllsagearevmhlhytdwpdhgvpqea...llellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

AKLYHNKRPGVWTSSEDIRVIYNIL
 .    .|||.  . | .. .|..|
veelraqrpgavqteeqylflyeal
0051082 (Phosphotyrosine protein) phosphatases II 987-1181 6.8e-17 56.9 In-house 3-146 (151) alignment 
Range on Protein: 987-1181
Range on HMM: 3-146/151.0
SDYINASWLHGFrrlrdFIVTQHPMAhtikDFWQMVWDHNAQTVVLLSSLDDI-NFAQFWPDEAtpiesdhyrvkflnktnksdyvsrdfviqsiqddye
|||||.|.. |.     ......|.|    ||........ .|.| | |.. . ......|..                                     
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

LTVKMLHCPSWPEMSNPNSiYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAiEMeycstANVYQYAKLYHNKRPGVWTSSEDIRVIY
..|. .....||. . | | .|......| ..| .|||...  . |     |..|.  .. ..      ....  . |. |||||..... .....
ievlhipildwpdpglpls.fdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfql
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 990-1167 4.6e-10 33.7 In-house 78-260 (301) alignment 
Range on Protein: 990-1167
Range on HMM: 78-260/301.0
INASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDIN---FAQ-FWPDEATPIESDHYRVKFLNKTN--KSDYVSRDFVIQSIQDD
| | |.    . . ||.|| |.  | .||| |.  .. ...|.|.   . .    .. .  . .  .. . ...|  ||    . . . | . ..   ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

YE-LTVKMLHCPSWPEMSNPNSIYDfIVDVHERCNDYRNgPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKR
..  ||      .|..   |.|  . . |. |   . .. |||.    |  .. .| .   || |.|   | .. .  |  ...|
fatrtvthyqysewtdrgvPkshae.lfdlmelvkksek.PivvhcsaGiGrsvafigteylareveadptieltealkhlrehr
0049260 (Phosphotyrosine protein) phosphatases II 995-1182 5e-18 60.7 In-house 2-144 (152) alignment 
Range on Protein: 995-1182
Range on HMM: 2-144/152.0
LHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEatpiesdhyrvkflnktnksdyvsrdfviqsiqddyeltvkMLHCP
..|... . || ||.|. .|..|||.|.......|.| | .|..... ...                                              .. 
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhl

SWPEMSNPNS--IYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAiemeycSTANVYQYAKLYHNKRPGVWTSSEDIRVIYN
 || .. |..  . .|.....|... ...||...  ..|   . |..|.  .          ..... .|. .||||. .. . .| .|.
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 995-1049 2.5e-08 27.7 In-house 229-283 (440) alignment 
Range on Protein: 995-1049
Range on HMM: 229-283/440.0
LHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEA
..|. .   || || |.  |. |||..| |..  |...|  |.|   . .|| ..
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvnt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1002-1182 9.9e-11 36.2 In-house 5-198 (199) alignment 
Range on Protein: 1002-1182
Range on HMM: 5-198/199.0
RDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL---DDINFAQFWPDEAT-PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLH--CPS
| .|.||||. .|. |||||||.  .  .|..       . ... .||   .   .     |     | |.||.   ... .       | .. |    |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEMSNPNSI--YDFIVDVHERCNDY---RNGPIVIVDRYGGAQACTFCAIS--SLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYN
| | . ||      |.|   |  . |   .. |...    |   .  | |.     . |    |  .... ||   . | |. .| .    ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1002-1182 1.1e-10 36.0 In-house 4-197 (198) alignment 
Range on Protein: 1002-1182
Range on HMM: 4-197/198.0
RDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL---DDINFAQFWPDEAT-PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLH--CPS
| .|.||||. .|. |||||||.  .  .|..       . ... .||   .   .     |     | |.||.   ... .       | .. |    |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEMSNPNSI--YDFIVDVHERCNDY---RNGPIVIVDRYGGAQACTFCAIS--SLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYN
| | . ||      |.|   |  . |   .. |...    |   .  | |.     . |    |  .... ||   . | |. .| .    ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
PTPc_DSPc_SM00012 1087-1184 1.4e-15 52.7 In-house 1-103 (105) alignment 
Range on Protein: 1087-1184
Range on HMM: 1-103/105.0
TVKMLHCPSWPEMSNP---NSIYDFIVDVHERCNDYR-NGPIVIVDRYGGAQACTFCAISSLAIEMEYC-STANVYQYAKLYHNKRPGVWTSSEDIRVIY
||| .|...||... |   .|| ... .|..  |.   ..|.|.... |  ...||.|.. |   .|.  .. ...|. | . ..|||.... |.  ..|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

NIL
..|
ral