Gene IA-2 in Drosophila melanogaster

Synonym: CG11344, CG31795, CG4355, Dmel\CG31795, R-PTPX/1A2, anon-WO0153538.69, ia2, Dmel_CG31795, IA-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP051_AA protein Get Run
DmelP051_AA_944-1223 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 929-1222 5e-78 257.8 In-house 3-289 (297) alignment
Range on Protein: 929-1222
Range on HMM: 3-289/297.0
WSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEpsaREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA-EGLDYVNASTITDHDPR
. ....|....|..... | .. ... .|..|..|.| |...  .   .. |  |.   .||    ||||||||.|... .  ...||.||| .. .| .
plrdallesipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydll

APAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEGAeVYHIYEVHLVSEHIwCDDYLVRSFYLKNlrTSETRTVTQFHFLSWP
 ....|.|||||.|...||.|.||||  ||| |..| |.|   ||.||||||  .|. . |.|....  .|.| || . ..|  ..|.||||.|....||
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp

HMGVPAQAKALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
..|||  .. ||.| ..|.. ..   ...|..|| ||| ||||..|...|.||...|. ...|.  ....|| || |.| | .|..|. .|..| .
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_PTPRN_pd Subfamily PTPRN 930-1227 2.2e-169 556.7 In-house 1-297 (297) alignment
Range on Protein: 930-1227
Range on HMM: 1-297/297.0
SEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAP
||||...|.||||||.||||.||||.|| ||..||||||.||||||..|.|......  ||  | |||||||| |.. |.||  ||.|||.|.|||||||
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHM
||.|.||||.||.|.||||.||||.||||.|.||.|.|  .|.||||.||.||||||||||||||||||||||||||||||.||||||||||||||||..
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

GVPAQAKALLDFRRKVNKSYRGrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
||||.||.||.||||||||||| ||||||||.|.||||||||||.||||.|..||..|||||||||||||||.|.|.|..||||.|.||||||.||||
gvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk

0050432 (Phosphotyrosine protein) phosphatases II 934-1226 2.3e-82 272.1 In-house 19-303 (308) alignment
Range on Protein: 934-1226
Range on HMM: 19-303/308.0
ALTNMDISTGHMVLSYMEDhLRNKGRLQREWEALCRYEAePSAREAASQPQCAGLNRPGAPLPYDHSRVVLnhlanAEGLDYVNASTITDHD-PRAPAYV
 |...   . . .| ..|. . ..|.|..|.|.|...   .  ...|..|.   .||    ||||||||.|      || ||.||| .. ..  .  ...
ilvsslklsvldllkllek.aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfI

AAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE---GAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHM
|.|||||.|...||.|.|||.  ||| |..|.||| . ||.|||.|   | ..|. . |.|.||.. .||| || ..|.||...|.||||.||...||..
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdh

GVPAQAKALLDFRRKVNKSYrgrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAIL
||| ....|||| ..|.||.   ...||||| ||| ||||..|.|||.||...|. ...|.  .. .|| ||.|.| | .|..|. .|..| .. .|
gvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0051299 (Phosphotyrosine protein) phosphatases II 937-1220 1.1e-81 269.8 In-house 2-284 (288) alignment
Range on Protein: 937-1220
Range on HMM: 2-284/288.0
NMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEpSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQG
...||. ...  ... ..... .|..|.|.|... .    . ||. |.    ||    ||||||||.|..| . || ||.||| | |  ..  ...|.||
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNL----RTSETRTVTQFHFLSWPHMGVP
|||.|...||.|.|||.  ||| |..|.|.| . ||.|||..| ..|. . |.|.||.. .||| || ....||     ..|.||||.||...||..|||
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

AQAKALLDFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
  ...|||| |.|.|...  ...|.||| ||| ||||..|.|||.||...|. ...|.  ....|| || |.| | .|..|| .|..|
dspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0045450 (Phosphotyrosine protein) phosphatases II 938-1220 4.2e-74 245.3 In-house 7-302 (307) alignment
Range on Protein: 938-1220
Range on HMM: 7-302/307.0
MDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAE-PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA-EGLDYVNASTITDHDP-------RA
. |.. ...| .....| .. .|..|.| |.... . .  ...|. |.   .||    |||||.||.|..| .  |. ||.||| ......       . 
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

PAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE-VYHIYEVHLVSEHIwCDDYLVRSFYLKNL-RTSETRTVTQFHFLSW
 ...|.|||||.|...||.|.||||  ||| |..| |.| . ||.|||.|| | .|. . |.|.||.. .|.| || . ...|  |.|.||||.||...|
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgw

PHMGVPAQAKALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGARE--IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
|..|||   . |||| ..|.| ..   ...|..|| ||| ||||..|...|.|....|.     .|.  ....||.|| |.| . .|..|. .|..|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0043336 (Phosphotyrosine protein) phosphatases II 940-1220 9.2e-76 250.2 In-house 2-275 (278) alignment
Range on Protein: 940-1220
Range on HMM: 2-275/278.0
ISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAepSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLP
||. ...  ..| .| .| .|..|.| |...      .. |  |.   .||    ||||||||.|..| . ...||.|||.. |  .. ....|.|||||
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

STLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPeEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALL
.|...||.|.||.|  .|| |..| |.| | ||.||| .| ..|. . |.|..|.  .||| || . ..||...|.||||..|.|.||..||| . . ||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
|| ..|.. ..  .. |..|| ||| ||||..|.|.|.||...|.  ..|.  ....|| ||.| | | .|..|. .|..|
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 940-1221 3.1e-60 199.2 In-house 16-290 (319) alignment
Range on Protein: 940-1221
Range on HMM: 16-290/319.0
ISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLP
. . .. ||  .|   .. .|. |. ..|.  .. . .. |  .|    || .  |..|...| |..|   |. ||.||| .| .  |   |.||||||.
fpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPld

STLAHFWQMIWEQGAVVIVALCrlqengEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLKN-LRTSETRTVTQFHFLSWPHMGVPAQAKAL
 ||| ||.||||. .  || |       .  |..||| .. . .  ..|.. | .  ...| ||.. | .  .  . | .|||||| ||..||| ..  |
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl

LDFRRKVNK-SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
. . .||..   . .   .|||| |||.||||||| || .|.||..  . .|.  ... ||.||  .|    |. |. .|. ||
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

0040438 (Phosphotyrosine protein) phosphatases II 944-1227 4.6e-78 258.0 In-house 4-281 (317) alignment
Range on Protein: 944-1227
Range on HMM: 4-281/317.0
HMVLSYMEDHLRNKGRLQREWEALCRYEAEpsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLA
...| ..  .......|..|.| |...  .   .. |. |.  ..||    ||||||||.|..| . ...||.||| . |   . ....|.|||||.|..
dlllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntve

HFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRR
.||.|.||||  ||| |..| |.| . ||.|||...  .|. . |.|.||.  .... .| . ...|..||.||||.||...||..|||   . |||| .
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

KVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
.|..... ....|..|| ||| ||||..|...|.||...|.  ..|.  ....|| ||.|.| | .|..|. .|..| .   |.
avreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt

subfamily_Ptp69D_pd Subfamily Ptp69D 947-1221 5.8e-56 184.9 In-house 11-285 (307) alignment
Range on Protein: 947-1221
Range on HMM: 11-285/307.0
LSYMEDHLRNKGRLQREWEALCRYEAEPSAReAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFW
 ..   .   .  |..|.| | . | . |.. .. .   |  ||  .  ..|. ||.|...   |  ||.||| |  .. .   ..|||.|. .|.  ||
ealksrkrdtdfglakeyekLeareidkstk.vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPveatigDfW

QMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLR-----TSETRTVTQFHFLSWPHMGVPAQAKALLDF
.||.||   .|| |  |.|  .  ||.|||.|    |    |.||||.  ..||  |.... .         ..| |.|.|...|. . || .|..||..
RmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

RRKVNKSYRGRRScPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 ..|.. |.  || ||||| |||.||.|... ||..|.....   ..|| .|  .|| ||  .|   .|..|.  |... 
ieqvrelyklnrs.PivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldy

0047943 (Phosphotyrosine protein) phosphatases II 949-1220 1.5e-76 252.7 In-house 3-270 (273) alignment
Range on Protein: 949-1220
Range on HMM: 3-270/273.0
YMEDHLRNKGRLQREWEALCRYEAePSAREAASQPQCAGLNRPGAPLPYDHSRVVLnhlaNAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQM
.. ..| ....|..|.|.|...   .  ...|. |.   .||    ||||||||.|    . .| ||.||| . |  .. ....|.|||||.|...||.|
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrm

IWEQGAVVIVALCRLQENGEVACARYWPEEG---AEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV
.|||.. ||| |..|.|.| . ||.|||.||    ..|. . |.|.||.. .||| || ..|.|| |.|.||||.||...|| .|||.. . ||.| ..|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

NKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.| ..   .. |.||| ||| ||||..|.|||.|....|. ...|.  .. .||.|| |.| | .|..|. .|..|
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_PTPRB_pd Subfamily PTPRB 949-1220 2.4e-66 218.7 In-house 16-283 (293) alignment
Range on Protein: 949-1220
Range on HMM: 16-283/293.0
YMEDHLRNKGRLQREWEALCRYEAEPSaREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQM
... . ... |.. |.| |   . . .  .||.... .  ||    |||||||| |..|.. .| ||.||. | ..  .   ..|.|||||.|. .||.|
vkkmkadsdlrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGPlpetvddfWrm

IWEQGAVVIVALCRLQENGEVACARYWPEE-GAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNlrTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
.||. . .|| | .| |.| | | .|||..  . .|   .|.||.|.   .|. .|.. ...  ..|.|.|.|.||.|||  ||| ..|.|||| |.|..
vwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

SY-RGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.  .  .. ||||| ||| ||||..| || .|.....    .||.... .|| .|. .| | .|. |.  .| .
aiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvld

subfamily_PTPN6_pd Subfamily PTPN6 949-1222 1.3e-64 213.2 In-house 18-297 (306) alignment
Range on Protein: 949-1222
Range on HMM: 18-297/306.0
YmEDHLRNKGRLQREWEALCRYEAE-PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNhLANAEGLDYVNASTITD-HDPRAPAYVAAQGPLPSTLAHFW
  |..  .|  .. |.|.| . ||.    |. ...|. .  ||  . ||.||.||.|.   .  | ||.||. |..       .|.|.|| |..|.. ||
k.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

QMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE-VYHIYEVHLVSEhIWCDDYLVRSFYLK-NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRK
.|.|.. . ||| . .  | |.  ||||||.| ..  |  ..|. |||    .|| .|.. .. . . .|.|.| |.|| |||  |||.. .|.||| ..
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VNKSYRGRR---SCPIVVHGSAGAGRTGVYILLDLVLERMNKG--AREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
||. ..  .   . ||||| ||| |||| .|..|..|. ..|     .|||  . . .|.|| |.| | ||. || .|... .
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 949-1224 1.6e-59 196.5 In-house 13-285 (305) alignment
Range on Protein: 949-1224
Range on HMM: 13-285/305.0
YMEDHLRNKGRLQREWEALCRYeAEPSarEAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQM
 .|..  ..  |. ....|..   |.   .  .. . .  ||  .. ..|..|. |..  . .  ||.||| .  .. |  .|..|||||..|.| ||..
ikearvysdkgleaqykslyee.eesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk.rkkkyivaqgPlkntvadfWrl

IWEQGAVVIVALCRLQENGEVACARYWPEEGAE--VYHIYEVHLVSEHIwCDDYLVRSFYLKN-LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV
|.|   ..|| |..|.|.|.  | .||||. .|   .  ..|.| ||.    ||. | . . .    .|.|||.|... .||  ||| .| .||.. ..|
iveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

NKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
.|...  .  |..|| ||| |||||.| .|. |||..|   ..|..  | .|| .| ..| | .|. |.  |..|....
qkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkE.evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 950-1224 1.2e-65 216.7 In-house 15-285 (319) alignment
Range on Protein: 950-1224
Range on HMM: 15-285/319.0
MEDHLRNKGRLQREWEALCryEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMI
.. .   .  |..|.. |   ||..   . ||...    ||    |.||..|||| .| . || ||.||| |  .. |  ...|.|.||  |.  ||.|.
kalastgetllekefkllk..eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPlentiedfWrmv

WEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLkNLRTSE--TRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
||... ..| |..|.|...| . .|||||  |.|  . | | .|.   .|| .| . | | ..||  ||.|..|....||  .|| .|..|||. ....|
WeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeee.eledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
| ..  | ||||| |||.|||| .| || .|||... .  .|.  |  .|| ||  .| . .|..|.  |. | |.|
srektqsgPivvhCsaGvGRtGtfivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_PTPN23_pd Subfamily PTPN23 950-1226 1.2e-55 183.3 In-house 7-284 (288) alignment
Range on Protein: 950-1226
Range on HMM: 7-284/288.0
MEDHLRNKGRLQREWEALCRYEAEPSAREA-ASQPQCAGLNRPGAPLPYDHSRVVLNhlanAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQM
 .  | .|. |..... | ..... .   . |     .  ||    |||||.||.|.     .  ||.||| . |  | .| ..|.|.||.|||. ||.|
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

IWEQGAVVIVALCRLQENGEVACARYWPEEGA--EVYHIYEVHLVSEHiWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVN
..|| . ||| |   .| |.  ..|||||.    ...  ..| | |..   . .  | . |. |.......|.  .. |||..||||  . ||.|  .|.
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

K---SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAIL
.   . . .   |.||| ||| |||||. |.  ... ..||   .||   ...|| ||  .| ...|..|.. || |... .|
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl

0036941 (Phosphotyrosine protein) phosphatases II 951-1221 8.5e-74 243.8 In-house 6-276 (297) alignment
Range on Protein: 951-1221
Range on HMM: 6-276/297.0
EDHLRNKGRLQREWEALCRYEAEPSaREAASQPQCAGLNRPGAPLPYDHSRVVLnhlaNAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIW
 ..| .. .|..|.| |... . .| ...|. |.   .||    |||||.||.|    . || ||.||| . |   .  ...|.|||||.|...||.|.|
lekllflalllkefeellpllllgs.lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvw

EQGAVVIVALCRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIW-CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
||.  ||| |..| |.| . ||.|||.|  .  .|. . |.|.|.... .||| .| . .......|.||||.||...||..|||  .. |||| ..|.|
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

SYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNK--GAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 ..   .. |..|| ||| ||.|..|..||.|.....    ...||  .. .||.||.|.| | .|..|. .|..| 
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 951-1224 3.3e-52 172.2 In-house 13-285 (290) alignment
Range on Protein: 951-1224
Range on HMM: 13-285/290.0
EDHLRNKGRLQREWEALCRYEAEPSAReAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEG--LDYVNASTITDHDPrAPAYVAAQGPLPSTLAHFWQM
..| ... . . ....|   | | ..   .  ..   |||    ..||  |..|..... .    .|.||. | ..   . .|.|.|||...||..||..
nghakgnegfrnqfkmldsgesehtvt.vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkl

IWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCdDYLVRSFYLKNLRT-SETRTVTQFHFLSWPHMG-VPAQAKALLDFRRkVN
||..   .|| |.  .|.|.| |  |||..... |  ....|..|..   .|  | . .|| ..  ....|||... .|.. | |....  || ... ..
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillviee.my

KSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
|  | |   .|||| |.. ||..|.. ..  ......    ||. . |...| |. | | | ||....   | . .. 
ktqrkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPN14_pd Subfamily PTPN14 951-1218 1.6e-51 170.1 In-house 17-292 (300) alignment
Range on Protein: 951-1218
Range on HMM: 17-292/300.0
EDHLRnKGRLQREWEALCRYEAePSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAeGLDYVNASTITDH-DPRAPAYVAAQGPLPSTLAHFWQMI
| .|. .|..  |.| . . ..  .  ..|. |. |  ||    |||...|| |.   ..   .|.|||.|      .   |..|||||. |.  ||||.
ekkle.egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmv

WEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI-YEVHLVSEHIW--CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVN
||||  .|| | . .|.|   . .|.|... .  .. .. . |...     | .  ... || | ..| |||  . .  ||  |||   |  |.. ..|.
WeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq

-------KSYR-GRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAV
       ..     .. |..|| |||.||||| || ||... .... .||||  .|..|| ||  .|.|  |..||  ..
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvl

subfamily_PTPN3_pd Subfamily PTPN3 952-1220 4.6e-59 194.6 In-house 10-273 (280) alignment
Range on Protein: 952-1220
Range on HMM: 10-273/280.0
DHLrNKGRLQREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNhlaNAEGlDYVNASTITDHDPR---APAYVAAQGPLPSTLAHFWQM
. | ..|..  ..| | | . .  | .|| .|. .  ||    ||||. || |.   ..|  ||.||...    |       |.|.||||..| ..||||
egl.esGavlaqfeqlyrkkpgl.aisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqm

IWEQGAVVIVALCRLQENGEVACARYWPEEGAEV-YHIYEVHLVSEhIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
.||| . .|| |  | |.| | | .||||.. |. |  ..|.. .|      |..| ..||. .|.| |...|. .|.||  ||| ... .|.| ..|.|
vweqksslivmlttlverGrvkChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrk

sYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNkGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
 .|  .. |.||| ||| |||||.|||.. |  ..  |... . . . ..||||| .| | .|..||  |. .
.lrsgkeePvvvhCsaGigrtGvlilletalalie.aaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_PTPRG_pd Subfamily PTPRG 953-1224 3.6e-59 195.4 In-house 14-289 (563) alignment
Range on Protein: 953-1224
Range on HMM: 14-289/563.0
HLRNKGRLQREWEALCRYEAEP-SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEG-LDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIW
|  .. ....|.||| .  ..     |....|.    ||    ..||.||| |. |.. .. |||.||. |  .  .. |..|.||||..|.  ||.|||
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiW

EQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDdYLVRSFYLKNLRTSE------TRTVTQFHFLSWPHMGVPAQAKALLDFRRK
|| . .|| .  |.|.|   | .|||....| |   .| |..|.. .  | ||.. .|||.  .       ..|.|.|. .|| .||| ..   | | .|
eqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkk

VNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 ... . .   ||||| |||.||||.|| || .|.....    ...  .| |.| ||  .|.|. |. |.  |. | . .
ssaank.aeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 954-1219 2.1e-63 209.1 In-house 17-276 (288) alignment
Range on Protein: 954-1219
Range on HMM: 17-276/288.0
LRNKGRLQREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQG
 ||.  ...|...|   | .  . .|..... |  ||    ||||. || |..| . .| ||.||| | ... .  .|.|.||||..|. .||....|. 
arnrtgfseeynsLaalektk.svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenk

AVVIVALCRLQENGEVACARYWPEEGA-EVYHIYEVHLVSEHiWCDDYLVRSFYLKnlRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR
.  || |  | |.|.  | .|||...  . |   .| ||...   .|...|.. |.  .. . ...||...|.|| .|||.... ||...|.|. .    
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

rSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
 . ||.|| ||| ||||..| || .......    ||.|.|...|| ||| .| | .|.||.  ...
.tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 954-1219 5.2e-50 164.9 In-house 6-274 (287) alignment
Range on Protein: 954-1219
Range on HMM: 6-274/287.0
LRNKGRLQREWEALCRY-EAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANaEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQ
.| |  ...| .||..  |. .    || .   .  || .  ||.|..||.| . ..  | ||.||  .. .  .  |..|||||...|.  ||....|.
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravlet

GAVVIVALCRLQENGEVACARYWPEEGAEV-YHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQA----KALLDFRRKVNK
 . ... . |  |..   | .||||    .    | | |..  |   .| ||.. | .| | |.| | |...||||  ...  |    .  || ..... 
rsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

SYRGRRSCPIVVHGSAGAGRTGVYILlDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
.  .    |.||| ..|.||.|...   ||| .. .   ..|.||.. .|| .||..| .  |. ..  |..
ardasevGPlvvhddvGiGrsGilla.tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_PTPRD_pd Subfamily PTPRD 955-1257 5.9e-83 274.4 In-house 20-314 (564) alignment
Range on Protein: 955-1257
Range on HMM: 20-314/564.0
RNKGRLQREWEALCRYeaEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGA
 .. ....|.. . .   . .  |||..|.    ||    ..||||||||... . || ||.||| |  .. .  ||.|.||||..|.. ||.|.|||  
nsdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqns

VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRS
 .|| | .|.|.|.| |..||||.| | |  ..| |..|.    || .|.| ||. ..||.|.|.|||| |||. ||| .|..|||..|||...   . .
stiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee.ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epda

CPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSgeKRELDKDPVVGGGSSSTT
 ||||| ||| ||||..| .| .|||...  . .||  ....|| ||  .| |..|. |.  |..| ...  . .....   |..|.|   |  ....|.
gPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl..kqhlqkLaeveedtemtg

TKE
 . 
lel

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 955-1225 2.5e-65 215.4 In-house 11-279 (281) alignment
Range on Protein: 955-1225
Range on HMM: 11-279/281.0
RNK-GRLQREWEALCRYEAEPSArEAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMIWEQG
.|.   ...|.|.|   . . .| .|. ...    ||      ||..||....  ...  ||.||. .   .  . .|.|.|||.|..|..||||.||| 
qndnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek.eyiatqgPvPaslvafWqmvweqk

AVVIVALCRLQENGEVACARYWPEEGAEV-YHIYEVHLVSEHiWCDDYLVRSFYLkNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR
. .|| . |  |.| . | ||||.. .|. |  . |. ..|.     |. | | | . ...|||.|.|.....||  ||||..|.||.||..|.|  . .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAI
. .|.|.| ||| ||||.|| || ....... ..|.|. |....|| .|  .| |  |.|||  || . ..  
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_PTPN9_pd Subfamily PTPN9 955-1220 5.6e-58 191.3 In-house 11-288 (297) alignment
Range on Protein: 955-1220
Range on HMM: 11-288/297.0
RNKGR--LQREWEALCRYEAEPSArEAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQ
..||.  |..|.... . ..|  . .|. ..     ||    | ||..||||... . |  ||.||. . |   .  |..|.||||. |   ||.|.|||
kekgkrGlskeyaeirnepveGtf.lasklranleknrytdvlcydetrvvlakvdedeasdyinanfv.dGykqkkafiatqGplkktvsdfWrmvWeq

GAVVIVALCRLQENGEVACARYWP--EEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK---
 ..|||   |. |.| . |..|||  || .. .  ..|. |. .   .|| ||.. .|| .|.|.|.|| | |||||  ||| .|..|||...|| .   
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

--------SYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
        . .|. .  ||||| ||| |||| .| ||. |.|... .  .|.  |...|| |||  . | .|.||  .|| |
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg.tvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 957-1231 1.8e-71 235.8 In-house 17-289 (318) alignment
Range on Protein: 957-1231
Range on HMM: 17-289/318.0
KG--RLQREWEALCRYEAEPSAREAaSQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGA
.|   |..|.|.| | |..... ..  .|  .  ||    |.|||.|| |..|.. || ||.||. | |   |  ||.|||.||| |.  ||.|.|||..
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWrmvWeqns

VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSeHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRS
 ||| | ...|.| . ..||||..|.. |    |.| . .. ..||..|.| ...  ..|.|.| |.|. |||  |||...  |||. |.|.|  .    
avivmltqeeergkakvhryWPskgsrsygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga

CPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPA
 ||||| ||| |||||.| .| .|||... |  .|.  | ..||.||  .| |..|.||.  .. | ...  .   |
gpivvhCsaGvGrtGvfiavdillerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 958-1223 4e-67 221.6 In-house 27-291 (298) alignment
Range on Protein: 958-1223
Range on HMM: 27-291/298.0
GRLQREWEALCRYEA--EPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMIWEQGAV
 ... |.. | . .   |    |.|..|.    ||    ...|.|||||..  . |  ||.||| .  .. |  |..|.|.||..|.. ||.|..|. . 
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedig

VIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSC
.|| |  |.| ... . .|||.||.| |   .|.| |..    |. || . ... .....|.| |.|| |||  |||..|...||..|||..| .     
tiVmltnleeldktkyhkywPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk

PIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|..|. ||| ||.| .| .| ||||..|  . .|.  ... || .|.|.| |..|. |. .|| | ..
pvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 959-1227 2.3e-25 84.1 In-house 7-264 (267) alignment
Range on Protein: 959-1227
Range on HMM: 7-264/267.0
RLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAegldYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIV
 ...|.| . .   . |        . .  ||    ||||..||.|    .     |.||| .  .  .  |... |.||  | ..|...| .|.  |||
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpviv

ALCRLQEnGEVacARYWPEE--GAEVYHIYEVHLVSEHiWCDDYLVRSFYLKnLRTSETRTVTQFHFLSWPHMGV-PAQAKALLDFrrkVNKSYRGRRSC
 | .  . ...   ..|| .   |. |.   |    |.   .|| . .. || ..   .. || ...  |          | |.     . |      . 
lltkvft.dni..rlfwPPkmgqakkyqdltvehslek.eendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgi...laknqlengnr

PIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
|.||. |.| ||.| .. .|  |||. .     ||   | ..|.|| |.| |.... ..   .||  .  ||
PlvvacsdGvGrsGtflvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk

0046845 (Phosphotyrosine protein) phosphatases II 960-1225 2.6e-77 255.3 In-house 2-277 (284) alignment
Range on Protein: 960-1225
Range on HMM: 2-277/284.0
LQREWEALCRYEAEPS-AREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA-EGLDYVNASTITDHD----PRAPAYVAAQGPLPSTLAHFWQMIWEQG
|..|.|.|...   ..  ...|  |.   .||    ||||||||.|..| .  |. ||.||| .. .|     . ....|.|||||.|...||.|.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AVVIVALCRLQENGEVACARYWPEEG-AEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLR-TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG
. ||| |..| ||| . ||.|||.||   .|. . |.|.||.. .||| || ..|.||  |.|.||||.||..|||..|||.... ||.| |.|..... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAI
  ...||||| ||| ||||..|.|||.||...|. .  ..|.  .. .||.|| | | | .|..|| .|..| .  .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

subfamily_PTPN13_pd Subfamily PTPN13 960-1220 2.2e-54 179.6 In-house 13-267 (273) alignment
Range on Protein: 960-1220
Range on HMM: 13-267/273.0
LQREWEALCRYEAEPSAREAASQpQCAGLNRPGAPLPYDHSRVVLNHLANaegldYVNASTIT-DHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIV
 . |.. |    .  ..... .. .    ||    ||||..|| |.  ..     |.||| |    .     |.|.||||| | . ||||.||| | ||.
Paeefkelrelkpldtcevgkkk.enkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

ALCRLQENGEVACARYWPEEGAEVYHIYE---VHLVSeHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRgrRSC
 .   .|.|.| | |||||.  .   ...   |.|.      |.. ||.. .|.....|.| |....| .||  |||..|. || | ..|..  .   . 
mvtlekekgkvkchrywPesknkklkvsnrlevellk.vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dag

PIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
||||| ||| ||.|..| .| ||. ...   |.|.  ....||.|| ||| |..|. ||  |. |
PivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykaile

DSPc_SM00195 961-1221 1.8e-70 232.7 In-house 3-261 (263) alignment
Range on Protein: 961-1221
Range on HMM: 3-261/263.0
QREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL
..| | | ... .    . | ...    ||    |||||.|| |..  . || ||.||. |. .  .  .|.|.|||||||...||.|.||..  .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

CRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRrSCPIV
.. .|||.  |.||||||  | |... ..|.||....  |.. .| . |..  ..|||.|||... .||. ||| ..| .|.. |.|.||..   | |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHGSAGAGRTGVYILLDLVLERMNKGAReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
|| ||| ||||.....|..|...... . .|| .....||.||.|.| |..|. |. .|..| 
VhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 961-1221 1.8e-70 232.7 In-house 3-261 (263) alignment
Range on Protein: 961-1221
Range on HMM: 3-261/263.0
QREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL
..| | | ... .    . | ...    ||    |||||.|| |..  . || ||.||. |. .  .  .|.|.|||||||...||.|.||..  .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

CRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRrSCPIV
.. .|||.  |.||||||  | |... ..|.||....  |.. .| . |..  ..|||.|||... .||. ||| ..| .|.. |.|.||..   | |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHGSAGAGRTGVYILLDLVLERMNKGAReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
|| ||| ||||.....|..|...... . .|| .....||.||.|.| |..|. |. .|..| 
VhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 961-1215 5.1e-24 79.5 In-house 25-280 (305) alignment
Range on Protein: 961-1215
Range on HMM: 25-280/305.0
QREWEALCRYEAEpSAREAASQPQCAGLNRPGAPLPYDHSRVVLnhlANAEGLDYVNASTITDhDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL
. |. |. |..      .|  . | || ||       |. || |    ..   .|. |  ..     .  .. .| ||  | | || | ...    |  |
raefvamkrfndf.ekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifml

CRLQENGEVACARYWPEEGAEVYHIYEVH-LV-----SE-HI----WCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSy
| |.| |   |. |.. .  .| .. |    .     |   .     ..  . ..  . .   ...| ||..|.  ||  ||||   |.|..  |   | 
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.

RGrrscPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVL
.|    ||||| ||| ||||  ..|. .|...  |    |    | ..|.||   . | .|. || 
kg....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

subfamily_PTPN1_pd Subfamily PTPN1 962-1227 5.6e-59 194.2 In-house 6-276 (290) alignment
Range on Protein: 962-1227
Range on HMM: 6-276/290.0
REWEALC---RYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANaeglDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIV
| .....   | ||.    ..| .|.  .|||     ||||||..|..  |    ||.||| . . .     |. .|||||.| .|||||.||| .  .|
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslv.eleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

ALCRLQENGEVACARYWPEEGA--EVYH---IYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYR-GR
 | .. |.... ||.|||..    |.      ..|.|.||..  . | || . |.||.| |||....||...|| .|||    |.|.|  || .|    .
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
   | |.| ||| ||.| ..|.| .| ...|      .||  .| .|| .| |.. | .|..|  .|. | .. | .
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 963-1221 6.6e-58 191.5 In-house 3-254 (284) alignment
Range on Protein: 963-1221
Range on HMM: 3-254/284.0
EWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCr
|. ..|.  .. . .. |  .|    || |  |..|...| |..|   |. ||.||| || .  |   |.|.||||. ||| ||.||||. .  || |  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt.

lqengEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLKN-LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS-YRGRRSCPIVVH
     .  |..||| .. . .. ..|.. | .  ...| ||.. | .  .  . |...||||| ||..||| ..  |. . .||..   . .   .||||
.....kdkcsqywplkivikeerfkvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

GSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 |||.||||||| || .|.||..  . .|.  ... ||.||  .|    |. |. .|. ||
csagvgrtgvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 963-1224 2.3e-49 162.9 In-house 25-280 (287) alignment
Range on Protein: 963-1224
Range on HMM: 25-280/287.0
EWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNhlanAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCR
 .  | . . ..     .  .|   .||    |..|  ||.|.     |  ||.||. |  .   . |...|..|. .|.  ||..|...   .|| ||.
qftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcq

LQENGEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLKNLR-TSETRTVTQFHFLSWPHMG-VPAQAKALLDFRRKVNKSYRgRRSCPIVVH
..|| | .| .||||| . |.  |...|..|.   ..|..| . .||   ......|.|... .|.  | |. ..  || . ... . .. |   .||||
ekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk.rgntsivvh

GSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 |.. ||.....  .  ... ..    ||.   |.. | |. | | | .|..|.  .| | ...
CsdtvGrsamfcaaattinkckteG.viDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 968-1221 2.5e-41 136.4 In-house 16-265 (283) alignment
Range on Protein: 968-1221
Range on HMM: 16-265/283.0
CRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANaeglDYVNASTIT--DHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQE
 |    .   . ||  .    ||    .|.|  || |. ...    ||.||. |.  ... .   |..||.||  |   ||.|.... .. || | .|||
krlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

NGEVACARYWPEEGAEVYHIYEVHLVSEhIWCDDYLVRSFYLKNL-RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRrKVNKSYRGRRSCPIVVHGSAG
. ...|..|||..|.| |  . | |  |    . . .. . |..   . .|  .. . .  | ..|  |   .|. |  ||    .  .  ||||| |.|
dlrikCsqyWPkrGsedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfn.kvislqteskkgPivvhCstg

AGRTGVYILLDLVLERMnKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 |||.|.| .   .. . .    .|. |... .| || ..| |..|. .|  .| |.
iGrtavfiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_PTPRK_pd Subfamily PTPRK 969-1223 1.6e-58 193.0 In-house 27-278 (314) alignment
Range on Protein: 969-1223
Range on HMM: 27-278/314.0
RYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGE
 ||. .   .|| . .    || |  |.||.|||.|  . .    ||.||. | |   |. |....||||..|.. ||........  || |  |.|.| 
eyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr

VACARYWPEEGAEvYHIYEVHLVSEHIWCdDYLVRSFYLKN--LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGrRSCPIVVHGSAGAG
| | .||||..   |   .|.||. .. . ...|| | ...     .|.|.| ||.||.||. .|| .|..||.. |.|.||    .  .|||| |||||
vkClkyWPedtev.ygdikvelvetella.elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaG

RTGVYILLDLVLErMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|||..| .| ||. | .  . .|.  .   ||...  .| | .|. |.  .. | . 
rtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl

subfamily_PTPN12_pd Subfamily PTPN12 971-1230 4.5e-67 221.0 In-house 25-285 (290) alignment
Range on Protein: 971-1230
Range on HMM: 25-285/290.0
EAEP-SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV
 ||    .||.....    ||    ||||.|||.|..  . || ||.||. |   .    .|.||||||| ||  ||.||||.   ..| .||. |.|  
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

ACARYWPEEGAE-V-YHIYEVHLVSEHIWCDDYLVRSFYLKNLrtSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsYRGRRSCPIVVHGSAGAGR
 |.||||||| | . .  .|| | .|.   ||.|.|.. ...   .|.|.|.|||. .||  |||..|| ||.. ..|.. .. . . |.||| ||| ||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvre.lqesedaPlvvhCsaGvGr

TGVYILLDLVLERMNKGAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALP
||. | .|.| | ....    |.|.   . .|| ||| .| |..|.|.| .|||| |.. |....
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiie

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 971-1222 9.7e-37 121.4 In-house 19-295 (297) alignment
Range on Protein: 971-1222
Range on HMM: 19-295/297.0
EAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHlaNAEGLDYVNASTITDHDPRAP-AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV
||.. .  .| .. .   ||    | .| .|| |       . ||.||  ..  |  |.  |. ||||| .|.  ||....||.  ||| ...|||.|  
eargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

ACARYWPEEGAEVYHIYEVhlVSEHI--WCDDYL-VRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRR--------------KVN------
 || |||.   |  .  .|  | |..    |..  |    |. .  ||.| |.   |||||  |||.. . |  |.                |.      
kcapywpsvvqerlkagdv..vveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

----KSYRG--RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
    .|.|    |. ...|| ||| ||.|| .| | .|... |. |  |.|| |..||.||| .| | .|||..  || . .
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_ptpA1_pd Subfamily ptpA1 971-1204 1.9e-32 107.5 In-house 33-278 (418) alignment
Range on Protein: 971-1204
Range on HMM: 33-278/418.0
EAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVA
   ||      . . .  ||    || .|.|| |... . || ||.||  |    |.   ....||||| |.| ||.|.||. . .|| | |  ||  . 
svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwrmvwenrcriivmlsresencrik

CARYWPEE-----------GAEVYHIYEVHLVsEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV----NK-SYRGRRS
| |||||.           | ||.  | | || | |   .  . .  ..     ||| .||...  ||   .| ... . .. . .    |.      | 
cdrywpeqiggeqfsiygngnevfgtysvelv.eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn

CPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDiAATLEHLRDQRAGV
 ||.|| ||| |||| .    ........  ...| |. .... |  . .
vpiivhcsagvgrtgtfctavimmkkldhyfkqld.atpidqvvdpfthl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 972-1223 2.3e-47 156.7 In-house 35-289 (325) alignment
Range on Protein: 972-1223
Range on HMM: 35-289/325.0
AEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMI--WEqgAVVIVALCRLqENGEV
 .. |...| .|.    ||    ...|.|||||. . ..   ||.||| . |.  .   ..||| ||..|.  .|...  |.  . |.| |  | ..|. 
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkd

ACARYWPEE--GAEVYHIYEVHLVSEHIWcDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS---YRG--RRSCPIVVHGS
 || |||.|   .  .   ||.|..      ||. | . .|. .  |||.| ||.. ||. |||. .  .|. . . |..     .   . | ||.|| |
rcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

AGAGRTGVYILLDLVLERMNKGAReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|| |||||.| |  .|... . .| .||   ...|| .|  .| |  |. ..  |..| . 
aGvGrtGvfislysalakvieesr.vdifgfvkklrkdrpsmvetvdqyiliyealveaym

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 972-1078 1.3e-11 38.6 In-house 83-181 (244) alignment
Range on Protein: 972-1078
Range on HMM: 83-181/244.0
AEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHlaNAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvac
 .||  . | .|. .  || || ||.| .|| |..   . |  |.||| .     |.  |. .| ||  |   ||.|. |.   |.| |  ..|. |   
pdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgcl.grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede...

arYWPEE
  |||. 
..ywpds

0045098 (Phosphotyrosine protein) phosphatases II 973-1223 4.3e-68 225.0 In-house 21-273 (278) alignment
Range on Protein: 973-1223
Range on HMM: 21-273/278.0
EPSAREAASQPQCAGLNRPGAPLPYDHSRVVlnhlanaeglDYVNASTITDHdPraPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACA
 ||  . |  . .. .||    ||||||||.          ||.||| |. . |  ....|.|||||||.|.||.|.||.|  ||| |..|.|.| . ||
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

RYWPEEGAEVYHIYEVHLVSEHIWcDDYLVRSFYLKNL----RTSETRTVTQFHFLSWPHMGVPAQA--KALLDFRRKVNKSYR------------GRRS
.||||.| ..|. ..|.|.||... ||| .| ... ||     . |.|.||..|.|.|| .||| .   | .|.. . ... ..              ..
qywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

CPIVVHGSAGAGRTGVYILLDLVLERMnkGaREIDIAATLEHLRDQRAG-VVATRQQFEFVLMAVAEEVH
.|..|| ||| ||||......|.||..  . . .|.  ....|| || | .| . .|..|. ....| ..
gpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPRA_pd Subfamily PTPRA 975-1220 7.6e-63 207.4 In-house 48-293 (330) alignment
Range on Protein: 975-1220
Range on HMM: 48-293/330.0
SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRaPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARY
.. |.||. .    ||    ||||.|||.|...   |  ||.||| |  .  .   ..|||||.  |.  ||.||||| .  || |  |.|  |  ||.|
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPEEGAEVYHIYEVHlVSEHIWCDDYLVRSFYLK----NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRScPIVVHGSAGAGRTGV
||.||.  |    |. | ..  . || || | ..    . |  ..| |.|||| |||..|||.... .|.. .||.|  .   . ||||| |||.|||| 
wPdeGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGt

YILLDLVLERMnKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.| || ||||. |  | .|.  ....|| ||. .| | .|.||.  .. |
fivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 975-1224 8.5e-54 177.5 In-house 34-279 (315) alignment
Range on Protein: 975-1224
Range on HMM: 34-279/315.0
SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPrAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARY
. . .| ...    || .  ||.|..||.|. . .    ||.||| |   |    ||.|.||||....  ||.|.... .  || .  .||.  . |..|
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPEEGAEV--YHIYEVHLVSEHiWCDDYLVRSFYLKNlrTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyRGRRSCPIVVHGSAGAGRTGVYI
||.. |.   .  ..|.|.| .  . |  .| . ...  . |.||||||.|  ||. ||. |. .|| . ..|  . .|..  ...|| |||.||||| |
wPdrkadsvefGsikvellsle.adtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvi

LLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 .| |...... .| .|.  ... ||..|  .| |.... |.  || |... 
sidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllw

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 978-1222 2.6e-39 129.7 In-house 38-236 (392) alignment
Range on Protein: 978-1222
Range on HMM: 38-236/392.0
EAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRaPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGevacarywpe
 .| ..     || .  |||| .||.|. . .    ||.||| |   |    ||.|.||| ...|  ||.|.... .  |. . .|.|            
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

egaevyhiyevhlvsehiwcddylvrsfylknlRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRSCPIVVHGSAGAGRTGVYILLDLV
                                 .  ..|||.||||  ||  .|| .. .|| | ..|.  . |. . |...| ||| ||||| | .| |
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf.Gqythpliihcsagvgrtgvvisidsv

LERmNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
. .  | .| .|.   .  .| .|  .| |..|. |.  || |..
vah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 980-1223 8.4e-62 203.6 In-house 4-243 (250) alignment
Range on Protein: 980-1223
Range on HMM: 4-243/250.0
ASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRaPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVaCARYWPEEG
| .||    ||    ...|.|||||..    .  ||.||| .  .| |  |..|.||||..|. .||.|..|. . .|| |  |.|.... . .||| |.
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

AEVYHIYEVHLVSEHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLE
|| |    |.| |....  || .| . | . . .. |.| |.||..||  |||..|.| |....||..| .   . |..|. ||| ||.| .| .| |||
aekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|..|  . .|.   .. || .| ..| ...|. || ... . . 
rlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

0049772 (Phosphotyrosine protein) phosphatases II 981-1222 3.5e-29 97.9 In-house 42-280 (314) alignment
Range on Protein: 981-1222
Range on HMM: 42-280/314.0
SQPQCAGLNRPGAPLPYDhSRVVLnHLANAEGLDYVNASTITDHdpraPAYVAAQGPLPSTLAHF----------WQMI--WEQGAVVIVA---------
...     ||    ||.| .||.| .  . .| || ||| .  .     ...|.||||. |.  |          |.|.  ...   .||          
dlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LCRLQENGevacaRYWPEEGAEVYHiyevhlvsehiwC-----DDYlvrsfylknlrtseTRTVTQFHFLSWPHMGVPaQAKALLDFR
            |..| .||      .....  | ..                  ...              .|.. ... . .|  ..|   . ...| 
lsrLdaAlgKtpllildgng.....neptaadlellk............eelydpelf..............erlgikylripvpDgsap.lledfdefl

RKVNKSyrgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNkgareIDIAATLEHLRDQRA-----GVVATRQQFEFVLMAVAEEV
. ...    ..  |..|| .|| ||||......... ...     .... .||..| .|      | . . .|.||.|.|. | .
efieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 982-1219 4.1e-33 109.4 In-house 37-290 (301) alignment
Range on Protein: 982-1219
Range on HMM: 37-290/301.0
QPQCAGLNRPGAPLPYDHSRVVLNHLAN--AEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG
. . . |||     .||. |..|..  |      .|.||| | .   .. ...|||||. .||. ||..||..  | || .. |.|. .  | .|||.  
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse

AEVYHIYEVH-LVSEHIWCDDYLVRSFYLKNL---------------RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSA
|| .. .... .....    |...|.. .|                 .. ....|.|..  .||. ||  . .  |    .| .  .     |.||| |.
aeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSd

GAGRTGVYILLDLVLERMnKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
. .|.|||. ... ||   |    .|.    . .| .. |.| | .|. ..  .. 
tVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

subfamily_CG42327_pd Subfamily CG42327 983-1148 3.5e-27 89.9 In-house 26-193 (319) alignment
Range on Protein: 983-1148
Range on HMM: 26-193/319.0
PQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE----
. .   .|    .|  ..||||.. .. .   |..|| .  .|     |.||| .| .. . ||...||| . ||| |. |.|.|   ||.|.| .    
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

GAEVYHIYEVHLVSEHiWCDDYLVRSFYLKNLRTSETRTVTQFHFlSWPHMGVPAQAKALLDFRRKVNKS
. ..|  . | |       | |.. .. ||..  .|.| .| . .  |.. .|||. .||.    .|..|
ntslyGdilvtlkgre.vkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

0040439 (Phosphotyrosine protein) phosphatases II 986-1220 2e-66 219.5 In-house 12-244 (249) alignment
Range on Protein: 986-1220
Range on HMM: 12-244/249.0
AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI
  .||    ||||||||.|..| . .. ||.||| | |   . ....|.|||||.|...||.|.||.|  ||| |..|.|.| . ||.|||..|  .|. 
kdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygd

YEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKG
. |.|.|... .||| || ..|.|| ..|.|||.......||..|||   . |||| ..|.| ..   ...|..|| ||| ||||..|...|.||...| 
ftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

aREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
 ...|.  ....||.|| |.| . .|..|...|..|
.lgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 986-1224 4.2e-48 158.7 In-house 21-266 (270) alignment
Range on Protein: 986-1224
Range on HMM: 21-266/270.0
AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE--VY
. |||    ||  ..||.|..| . .   |.||  .   | .  .|.||.||||.|| .||.||||. .  || .  |.|.|   |.||||.|  |   .
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

HIYEVHLVSEH-IWCDDYLVRSFYLKnlRTSETRTVTQFHFLSWPHMGVPAQAK------ALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLD
.  ... ....    . |...   |.  ...|.| .. |.. .||  ||| ..        ||   |.| .| .   .. |..|| ||| ||||. |.||
edgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

LVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 ... ...  ...|..| .|.|| .|  .| . .|.||.  ||.| .. 
iavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_CG7180_pd Subfamily CG7180 986-1221 3.1e-41 136.0 In-house 43-289 (296) alignment
Range on Protein: 986-1221
Range on HMM: 43-289/296.0
AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEGAEVYHI
 . ||    .|||. ||||..|   |  ||.||. .  .  .  .|.  ..|  .|.  ||........  .| |..  .  .  .  |||... | |  
reknrdvkvvPyDynRvvLekldGeeksdYinavyvdsf.lkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

YEVHLVSEHIWCDdYLVRSFYLKNL----------RTSETRTVTQFHFLSWPH-MGVPAQAKALLDFRRKVNkSYRGRR-----SCPIVVHGSAGAGRTG
 .|..|.|. . .    | | |.             . |||.|..|..  |.    ||  ..||...||.|. ..|..        |.||. | ||.|.|
ifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr.lwrekvdedpeegPvvvvssdGasRsG

VYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
||. .|  || ..|   |.|.   .  || .| ..| . ... ..   . | 
vylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

0042113 (Phosphotyrosine protein) phosphatases II 987-1220 4.2e-66 218.1 In-house 11-241 (245) alignment
Range on Protein: 987-1220
Range on HMM: 11-241/245.0
GLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIY
 .||   .|||||.||.|..  . ...||.||| . | . . | . |.|||||.|...||.|.||.|  .|| |... |.| | ||.|||...  .|. .
dknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdf

EVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaR
 |.|.||.. .||| || . ..||...|.|.|...|.|.||..|||   . |||| . |.| ..  .. |..|| ||| ||||..|...|.||...|  .
tvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke.l

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
....  ....||.|| |.| | .|..|. .|..|
gvsleeavkelrsqRpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 988-1220 2.5e-59 196.1 In-house 13-240 (243) alignment
Range on Protein: 988-1220
Range on HMM: 13-240/243.0
LNRPGAPLPYDHSRVVLnhlanaEGLDYVNASTITDHdPRapaYVAAQGPLPSTLAH----FWQMIWEQGAVVIVALCRLQENGEVACARYWPeE-GaeV
 ||    ||||||||.|      || ||.||. |.   ||   . | |||||.|...    ||.|.||.|  ||| |..|.|.| . ||.||| .    .
knrysdilpydhsrvkl......egsdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gev..t

YHIYEVHLVSEHIwCDDYLVRSFYLKNLR-TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG-------RRSCPIVVHGSAGAGRTGVYILL
|. ..|.|.||.  .||| || ..|.||  . .||.|...|.|.||..|||   . |||| ..|.. ..         .. |..|| ||| ||||..|..
ygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

DLVLERMnkgarEIDIAATLEHLRDQRAG-VVATRQQFEFVLMAVAE
.|.|...     ..|.  ....||.|| | .| |..|..|. .|..|
ylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle

0041856 (Phosphotyrosine protein) phosphatases II 988-1222 6.6e-38 125.5 In-house 4-171 (182) alignment
Range on Protein: 988-1222
Range on HMM: 4-171/182.0
LNRPGAPLPYDHSRvvlnhlanaeGLDYVNASTITDHDPRAPaYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCrlqengevaCARYWPeegaevyhiye
.||    |||||||          .|||.||. .    |    ..|.||||.||.|.|..|..|.|  .|| |.         . .|||           
knrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

vhlvsehiwcddylvrsfylknlrTSETRTVTQFHFLSWPHMGVPAqAKALLDFRRKVNKsyrgrRSCPIVVHGSAGAGRTGVYILLDLVLERmnkgarE
                        . ..|...|...|.|| .|||     |||| ..|..     ...|..|| ||| ||||......|....      .
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl......g

IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
...  .....| .| |.| | .|. |. .|. |..
vsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 988-1085 2.2e-16 54.5 In-house 50-160 (350) alignment
Range on Protein: 988-1085
Range on HMM: 50-160/350.0
LNRPGAPLPYDHSRVVLNHLA--------NAEGLDYVNASTITDH---DPRAPA--YVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARY
 ||    |||.|||| |..            .. ||.||. .          |   |.|.|.|||||.  |...| . .  ||..|  ..|..   | ||
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPEEGAEVYHI
|.| . . ...
Wqegsydditv

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 988-1105 1.6e-08 27.7 In-house 30-111 (169) alignment
Range on Protein: 988-1105
Range on HMM: 30-111/169.0
LNRPGAPLPYDHSRVVLNHLANAEGLDYVNAstitdhdprapayvaaqgplpstlahfwQMIWEQGAVVIVALCRLQENgevacARYWPEEgaEVYHIYE
 ||| .||   | || |... .  | ||.||                            .||||  | ||| |   ..        .|||   | | .. 
knrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddk.....nnfwpek..edyqlhp

VHLVSEHiWCDDYLVRSF
  .. |  . |   ||. 
avilgew.ytdslyvrtd

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 988-1105 2e-08 27.3 In-house 29-110 (169) alignment
Range on Protein: 988-1105
Range on HMM: 29-110/169.0
LNRPGAPLPYDHSRVVLNHLANAEGLDYVNAstitdhdprapayvaaqgplpstlahfwQMIWEQGAVVIVALCRLQENgevacARYWPEEgaEVYHIYE
 ||| .||   | || |... .  | ||.||                            .||||  | ||| |   ..        .|||   | | .. 
knrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddk.....nnfwpek..edyqlhp

VHLVSEHiWCDDYLVRSF
  .. |  . |   ||. 
avilGew.ytdslyvrtd

Y_phosphatase Protein-tyrosine phosphatase 989-1220 1.8e-67 222.6 Pfam-A 5-235 (235) alignment
Range on Protein: 989-1220
Range on HMM: 5-235/235.0
NRPGAPLPYDHSRVVLNHLANAEGldYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWP--EEGAEVYHIY
||    ||||..|| |..  ...   |.||.... .. .  ...|.||||.||...||.|.|..   ||| |..|.|.|...||.|||  ||. . |. .
nRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVHLV-SEHIWCDDYLVRSFYLKNLRTS-ETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG
.|.|. .|. ....| .| . ||.  .. |.|.|.|.|. .||. |||...|.|||. |||.||    .| |.||| |||.||||....||..||.....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

AReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
   .|.  ....|| ||.|.| . .|..|. .|..|
ee.vdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 989-1220 1.8e-67 222.6 In-house 5-235 (235) alignment
Range on Protein: 989-1220
Range on HMM: 5-235/235.0
NRPGAPLPYDHSRVVLNHLANAEGldYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWP--EEGAEVYHIY
||    ||||..|| |..  ...   |.||.... .. .  ...|.||||.||...||.|.|..   ||| |..|.|.|...||.|||  ||. . |. .
nRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVHLV-SEHIWCDDYLVRSFYLKNLRTS-ETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG
.|.|. .|. ....| .| . ||.  .. |.|.|.|.|. .||. |||...|.|||. |||.||    .| |.||| |||.||||....||..||.....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

AReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
   .|.  ....|| ||.|.| . .|..|. .|..|
ee.vdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 989-1223 1.9e-54 179.6 In-house 47-277 (515) alignment
Range on Protein: 989-1223
Range on HMM: 47-277/515.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPrAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE-V-YHIY
|| .  |||| .|| |. . ..   ||.||| |   |    ||.|.|||.....  ||......    |. . .|.|.  . |..|||.  .. | .  .
nryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsi

EVHLVSEHIwCDDYLVRSfyLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVnKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAR
.|.||| .  | . . |   |. |. ...||||||||  ||. ||| ....|| . ..| |. .|. . |...| |||.|||||.| .| |. .... .|
kvelvslea.ctggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakt.tr

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
 .|.  ... .|..|  .| |..|. |.  || |...
mvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 989-1223 5e-53 174.9 In-house 32-269 (274) alignment
Range on Protein: 989-1223
Range on HMM: 32-269/274.0
NRPGAPLPYDHSRVVLN-HLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG-AEV---Y
||  . || ..|||.|. . ...| ..|.||  |   | .  ||||.|||||.|.| ||.||... . ||| | .|.|. |  ||.|.|..  .|.   |
nryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeisery

HIYEVHlVSEHIWCDDYLVRSFYLKNLRTseTRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR--RSCPIVVHGSAGAGRTGVYILLDLVLERM
   |.. |.. . ..|| ||...||.|    .|.|. . . .|| . .| .|..|||. ..|..| . .  .  |.||| ||| ||||..|  .. . ..
gdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrql

NKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
..    .|.  .  .|| .| |.| |..|.|..  |... ..
ree.ivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 989-1218 3.4e-51 168.8 In-house 7-235 (237) alignment
Range on Protein: 989-1218
Range on HMM: 7-235/237.0
NRPGAPLPYDHSRVVLNHlaNAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE-GAEVYHIYE
|| |    ||||||||.   .  | ||.||. . . |     |.|||||| |.   ||||.|..   ||| |  | |. |. | .|||.    . | .. 
nrygnivaydhsrvvlkg..agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VHLVSEHIWCdDYLVRSFYLK-NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV-NKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLeRMNKGA
| |  .  .. || |||. |  .|.  | | . |..| |||. ||| |. ||| ||... |.|    .|.| ..| ||| ||||.....| .| |  |  
vslkkkeefs.dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.rqakek

REIDIAATLEHLRDQRAGVVATRQQFEFVLMAV
. .||   .  . ..|  .. |..|. |.  ..
kvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 989-1224 6.5e-49 161.6 In-house 55-286 (297) alignment
Range on Protein: 989-1224
Range on HMM: 55-286/297.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPrapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEGAEVYHIYEV
.|    |||| ||| |. . .    |||||| .         ... | | ..|.| ||.|.... . .|| |  ..|. .  |||||...|   .    |
sRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsv

HLVSEHiWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPA--QAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAR
 | | .  .  .. |.. ... ..  .| | |..|..||.  |.   .|..||..   |.|.. .. ..|..|| .|| |||||.. .| |. ....   
vllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr.ek

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
|.||  ....||..|  .| |..|..||  || | . .
evdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 989-1220 8.7e-49 161.1 In-house 53-277 (315) alignment
Range on Protein: 989-1220
Range on HMM: 53-277/315.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEgAEVYHIYEV
||    ..||.||| |  | | .. |||||. |  .. .   |.|||||.....  ||....|.    || |  | |. .  . .|||..   .|  . |
nryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitv

HLVSEHIWcDDYLVRSFylKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREI
 ..|| .  ..| ||..       .. |.| |.|. ||| ||||. . .|... |.|.. ..    ..|||| ||| |||| .| || ||....   . |
trkseevn.teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkq.hhtnsvgaivvhcsaGvGrtGtfitldavldqaea.enai

DIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
|.   .. .|..| ..|.. .|..|.  |. |
dvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 989-1220 2e-48 159.6 In-house 12-239 (239) alignment
Range on Protein: 989-1220
Range on HMM: 12-239/239.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEvYHIYEV
||    . ||||||||..|.|    ||.||| . |.|    ||.|.|| .  .   ||.|.|..  .||| |  | |  .  | .|||.  .. |    |
nryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrv

HLVSEHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS-YRGRRscPIVVHGSAGAGRTGVYILLDLVLeRMNKGARE
 |    ... ||..|.| . ..  .| | | |.||  ||  |||  | |.| .|||. |    | |  | |.| ||| |||| ....| .| |  |  . 
tlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml.rqakkqkt

IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.||   .. .|..|  .| | .|. |. .|| |
vdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 992-1084 6.9e-09 29.5 In-house 55-162 (349) alignment
Range on Protein: 992-1084
Range on HMM: 55-162/349.0
GAPLPYDHSRVVLNHLANA--------------EGLDYVNASTI--TDHDPRApAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYW
   |||.||||.|..  ..                 ||.||  .  |  ..    |.| | |||||.  |...|  .|  ....|   .|..   | .||
kdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek.kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw

PEEGAEVYH
 |   . ..
qelsysnit

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 993-1220 2e-48 159.6 In-house 15-238 (239) alignment
Range on Protein: 993-1220
Range on HMM: 15-238/239.0
APLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEvYHIYEVHLVS
  . ||||||||..|.|    ||.||| . |.|    ||.|.|| .  .   ||.|.|..  .||| |  | |  .  | .|||.  .. |    | |  
nivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrvtlrk

EHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS-YRGRRscPIVVHGSAGAGRTGVYILLDLVLeRMNKGAREIDIA
  ... ||..|.| . ..  .| | | |.||  ||  |||  | |.| .|||. |    | |  | |.| ||| |||| ....| .| |  |  . .|| 
tevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml.rqakkqktvdif

ATLEHLRDQRAGVVATRQQFEFVLMAVAE
  .. .|..|  .| | .|. |. .|| |
nyvkairedrphmvqtseqyvfihlavle

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 995-1222 9.7e-42 137.9 In-house 58-279 (439) alignment
Range on Protein: 995-1222
Range on HMM: 58-279/439.0
LPYDHSRVVLNHLANAEGLDYVNASTITD-HDPRapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvacarYWPEEGAEVYHIYEVhLVSE
 ..||.||.|. .       |.||  |   .|..   |.|.|||   |  .||....|. .| || |. | |        ||| ..  .|    |  |  
gafdhtrvtlqeipgvphshyinanyikGyyddk..lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiav.rvdr

HIWCDDYLVRSFYLKNLR--TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIA
 |   .| .| | . | |  |   ||| |||...||.  |||||  .||| | .| .   .   |.||| ||| ||||  | ||. ||...    ..|| 
nielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl.enkvdik

ATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
  .. ||.||  .| .  |. |.  || |..
givkvlrkqrkqmvqalcqyvfiynavledi

subfamily_eak_pd Subfamily eak 995-1142 9.6e-10 32.4 In-house 61-204 (332) alignment
Range on Protein: 995-1142
Range on HMM: 61-204/332.0
LPYDHSRVVLNHlANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEV--YHIYEVHLvS
.|||.  | |   .  . | |.||| . .       |. .  .  . .  ||||. || .  || |    |..     .|.|... |.  . |..|.   
vpydrylvrlts.sqlnrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver.k

EHIWCDDYLVRSFYLKnlRTSETRTVTQFHFLSWPHMGVPAQaKALLDFR
|..  . . .| . |.  .  ||  |  ...  |  . .|   . .| .|
efvkrniletrllels..kGnethrvlhykvfGwtettlpky.edflalr

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 995-1091 9.3e-06 20.0 In-house 3-83 (130) alignment
Range on Protein: 995-1091
Range on HMM: 3-83/130.0
LPYDHSRVVlnhlanaeGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvacarYWPEegAEVYHIYEVHLV
|... ||.         | .|.||| .   . |.  |. .| ||  |  .||.|. |.   |.| |  ..|. |     |||.  .| .. || ...
lefevsrlq........gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpd..sePlewyeedii

0044763 (Phosphotyrosine protein) phosphatases II 996-1216 9.1e-28 92.5 In-house 1-165 (178) alignment
Range on Protein: 996-1216
Range on HMM: 1-165/178.0
PYDHSRVVLNHLANAEGLDYVNASTITDHdprapAYVAAQGPlpstlAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAevyhiyevhlvsehi
|.|..||.|..| . |. || ||| |...      |.....|     |.......|.|  .|| |.  .|.| . | .|||||                 
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

wcddylvrsfylknlrtsetrtvTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERmnkgarEIDIAATLE
                        |.... .| .|||   . .|.| . ... .  .. .|..|| ||| ||.|. ....|....       ... . .|
.......................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaie

HLRDQRAgVVATRQQFEFVLM
..| .|  .| .. | .....
lvrerRp.ivpnpgqlrqLye

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 997-1215 4.3e-27 89.5 In-house 49-262 (281) alignment
Range on Protein: 997-1215
Range on HMM: 49-262/281.0
YDHSRVVLNH-LANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHI
 | ||| |.  . | .  ||. |  |         |. .|||   | | ||.|||.. .  || ||.. |     || |.| .   . .. .. .  |  
ldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyeds

WCDDYLVRSfYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsyrgrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLE
  .  || .  |.     ||| .|.. .  ||   ||  .. .|   ||.       || | |.| ||| ||.|  . ... |. .       ||   . 
tvnkslvtt.rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira.....rstppvihcsagvgrsgtlmaveialqsihshftlpdikqivs

HLRD-QRAGVVATRQQFEFVL
|||   ||  | | ||. .. 
hlrvtgraasvqtlqqymliw

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 997-1214 7.7e-26 85.8 In-house 53-269 (307) alignment
Range on Protein: 997-1214
Range on HMM: 53-269/307.0
YDHSRVVLNHLANAegLDYVNASTITD-HDPRapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE-GAEVYHIY------EV
 |..|.|..    |   ||. |  .    .|.   ...||||| .|  .|| |. ..    .. ||.. | ... | .||| | | .  .          
qdkgrivvkfdgla..sdyihanylgiaikpk..kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisva

HLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREI
 | ....  |. |.    ||   ....||.... .  ||  |||    . ...   |.         |.||| ||| ||.|  . . || ..| .|    
nlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinck

DIAATLEHLRDQRAGVVATRQQFEFV
|.   .| ||.||   . |  |. ..
dmkklveelrsqrhyaiqteaqylyl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 997-1214 2.4e-19 64.1 In-house 64-282 (310) alignment
Range on Protein: 997-1214
Range on HMM: 64-282/310.0
YDHSRVVLNhLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG-AEVYHIYEVHLVSEHI
 | ||| |. . ..   ||. |  .     |. ... .||||  |.  ||.||... |  |. ||.  |.|   |  |||  | .| |    |  .||  
ldtsrvklk.idksryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess

--WCDDYLVRSFYLKNLRTSETR------TVTQFHFLSWPHMGVPAQAKALLDfRRKVNKSyrgrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArE
  .    |  .|   |.   |         |.  ..  || .||| .    .  .| . .     |  | ||| ||| .|..| . |.| ......|  .
eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv....rhgpcvvhcsagkdrlyvvvalklkidkldrgl.k

IDIAATLEHLRDQRAGVVATRQQFEFV
.|.     .|. .|| .. |  |. ..
vdaeevktellksraiciqtelqylii

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 997-1224 9.4e-13 42.4 In-house 59-281 (303) alignment
Range on Protein: 997-1224
Range on HMM: 59-281/303.0
YDHSRVVLNHlanAeglDYVNASTItDHDPRAPAyVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAevYHIYEVHLVSEHIW
 |||.| |     .    |. || . . | .  | . .| ||. | | ||||| ||   ... |    |  ..     .|..    .  .|   .    .
ldhskvklsd...s...syihasyl.eldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd..flkfeersirvgef

CDDYLVRSFYLKNLRTSETRTV---TQFHFLSWPHMGVPAQ-AKALLDFRRKVNKSYRG-RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIA
    |.  . || |  |.          |. .|||  .|.. .  ..    ...   |    | | |    .| ||.| . |..     . .    .|. 
krvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlv

ATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
  || .|. |   |    || .|   .|| |  
kclenvrngrlhavqnlsqfsvvytllaehvld

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 998-1214 1.9e-27 90.7 In-house 69-275 (290) alignment
Range on Protein: 998-1214
Range on HMM: 69-275/290.0
DHSRVVLNHlanAEGLDYVNASTITDHDpraPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLV-SEHIW
| .||.|.        ||| |  .   .   . .. .||.| .|   .|.|. .... .|| || | |.|   |..|.||.  ||  . |. .. ||.  
dktrvilkd...GydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseedd

CDD-YLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLE
 |.    . . ...  .     .  ..  |||   |.  . |||   | . |      | |.||| ||| |||| .. ..  |. . .| .|.|.. .  
kdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldG.keldlldlvr

HLRDQRAGVVATRQQFEFV
 ||. |.. |    |.  .
alrnsrlnsvqvdiqylal

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 998-1222 1.8e-23 78.0 In-house 56-271 (288) alignment
Range on Protein: 998-1222
Range on HMM: 56-271/288.0
DHSRVVLNhlanaEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWC
| .|| |.     .  |.  |. .    .     . || || .|.  .|.|. |..   || ||.| | |  . | |.| .  |  .|  .  |  .   
ditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkra

-DDYLVRSFYLKNLRTSETRT-VTQFHFLSWPHMGVPAQAKALLDFRRKVnKSYrgrrSCPIVVHGSAGAGRTGVYILLdLVLERMNKGAREIDIAATLE
  | ||.   |.. .. |..  | . |.| |.. ||| . .. | .   . ||.      ||||| |||.||||  ||  |.  .. .    . |   |.
didklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.ksl....qkPivvhssaGvGrtgtlili.lialeslrlddflgirslla

HLRDQRAGVVATRQQFEFVLMAVAEEV
.||..|   . | .|. .|   | ||.
klreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 998-1220 2.6e-23 77.4 In-house 48-268 (285) alignment
Range on Protein: 998-1220
Range on HMM: 48-268/285.0
DHSRVVLNhlaNaEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYH--IYEVHLVSE-H
. .||||.   |    ||. || .        .|...||||| ||. ||.||...    .. || | | |   || |.||.  || .   ||. |     
eetrvvlk...n.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitltecke

IWCDDYLVRSFYLKNL--RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAA
      .. .. . |    .||   . . .   ||    | .|. .... . |.|     .  ||.|| ||| |||  .. .|    |. .   .|..  
eaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyatirime.npniemld

TLEHLRDQRAGVVATRQQFEFVLMAVAE
 .  .|  |   | .. || |. . . |
ivremramrfqavqshmqflflyvvlme

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 998-1219 2.3e-13 44.2 In-house 64-282 (302) alignment
Range on Protein: 998-1219
Range on HMM: 64-282/302.0
DHSRVVLNHLANaeglDYVNASTITDHDPRAPAYVaAQGPLPSTL---AHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEgAEVYHIYEVHLVSE-
|. .| |.. ..    .|||||...  . . . .. || |  ..    ..||.|....  | .| | . .|  . .   ..|.. .. |. |.   |   
dsnlvkleaepd....syvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk.sgdykeygkmfvNnr

HIWCDDYLVRSFYLKNLR--TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV-NKSYRGRRSCpiVVHGSAGAGRTGVYILLDLVLERMNKGaREIDI
 .   .  .  ...  |    |..  ..  ..  |..  || .  .|     || .|.  .  ..  |.    |||| |. . | ...|...||  |  |
kVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadent..vivSknGaGRagafltlavaveklqkg.kepni

AATLEHLRDQRAGVVATRQQFEFVLMAVA
. ... .| ||. .| . .|. .. .|..
keivksiRsqRpravdslkQyvslyiall

subfamily_egg_pd Subfamily egg 998-1219 4.7e-10 33.6 In-house 53-267 (307) alignment
Range on Protein: 998-1219
Range on HMM: 53-267/307.0
DHSRVVLNHLANAEGLDYVNASTITDhDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENgeVACARYWPEEGAEVYHIYEVHLVSEHIWC
| ||| |.        |.. |  .   .|    .. || ||  |   ||.|....    || |   .|.    |  |||   ..   .    |  | .  
dssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkv

DDYLVRSFYLKNLRTSETRtVTQFHFLSWpHMGVpaQAKALLDFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGA-REIDIAATLEH
|.     | . .|.   .    . .   |    |  .  . . .  .| .  | . | |.||.   |  .... . ... |  . .|      .  .   
dskadplfrvtklklvGgd.deerflehw.qgdv..nnssdvysplrvlrklr.nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvf

LRDQRAGVVATRQQFEFVLMAVA
|| .|   | .  .. ||   |.
lrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 999-1219 7.8e-16 53.0 In-house 32-256 (290) alignment
Range on Protein: 999-1219
Range on HMM: 32-256/290.0
HSRVVLNHLANAEGLDYVNASTITDhdPRAPAYVAAQGPL-------PSTLAHFWQMIWEQGAVVIVALCRLQENGEV----ACARYWPEEGAEVYHIYE
..||||.   .    ||. |. .|   |   . .. | |.        ||. .|| |. .  .  .| ||  .|. .     |||.| ||.  |   .  
atrvvLkgygkrfnddyiHAnrvtc..pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

VHLV-SEHIWCDDYLVRSFYLKnLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAR
. .   . .  ||  .|   .|     |  |||   . .| .. |. . | ||.  .||..|       |..||   |  |  .   ..|    . .   
ltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
.. ... |. || ||| .. . ... ||. .. 
svkledvlkalrkqralaitsalelafvdagiv

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1007-1214 2.7e-24 80.3 In-house 74-281 (305) alignment
Range on Protein: 1007-1214
Range on HMM: 74-281/305.0
LANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEvHLVSEHIWCDDYLVRSF-
|..    ||. |  .         ...|||||  |. .|| |. ..    || ||.  | | . ||.|||    |  ..    .| | .     . |   
ldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks.givvenvsgskpmerdae

---YLKNLRT--SETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVnksyRGRRsCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQ
    | ||    ... .| ....  ||  |||    . |..   .    || .  ||||| ||| ||||  . .. .||.. .  .   .   .  ||||
iqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai....rgsk.vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdq

RAGVVATRQQFEFV
||  . .  |. |.
rafsiqndvqylfi

0043147 (Phosphotyrosine protein) phosphatases II 1011-1215 8.3e-33 108.9 In-house 3-154 (172) alignment
Range on Protein: 1011-1215
Range on HMM: 3-154/172.0
EGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLqengevacarywpeegaevyhiyevhlvsehiwcddylvrsfylKNL
|| ||.||| . |     . ..| ||||..|||.||.|..|.|  .|| |..|                                             ..
egsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

RTSETRTVTQFHFLSWPHMGVPaQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLermnkgaREIDIAATLEHLRDQRAGVVATRQQ
.. ..|.. |...|.|| .|||  .. ||.| . ... .  ....|..|| ||| ||||. ....|.|       . ...  .....|..| |.| . .|
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsq

FEFVL
  |..
yrfly

0046846 (Phosphotyrosine protein) phosphatases II 1013-1218 2.3e-32 107.5 In-house 12-169 (176) alignment
Range on Protein: 1013-1218
Range on HMM: 12-169/176.0
LDYVNASTITDHdprapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYhiyevhlvsehiwcddylvrsfylknlrt
|||.||. |  .     ...| |||||.|||.|..|..|.|  ..| |. ..| | . |..||||. .. .                             
ldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

setrtvtQFHFLSWPHMGVPAQaKALLDFRRKVNKSYRGRrsCPIVVHGSAGAGRTGVYILLDLVLERmnkgaREIDIAATLEHLRDQRA-GVVATRQQF
       |...| || .|||   ..||.. . ... ..     |..|| ||| ||||......|.  .     . ...  .|...|.||  |.| |..| 
.......qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQy

EFVLMAV
.|. ...
rflyefe

0051429 (Phosphotyrosine protein) phosphatases II 1014-1224 1.1e-37 125.6 In-house 5-227 (272) alignment
Range on Protein: 1014-1224
Range on HMM: 5-227/272.0
DYVNASTITDHdPR---APAYVAAQGPLPSTLAHFWQMiWEQGAVVIVALCRLQENGEVACARYWP------------EEGAEVYHIYEVHLVSEHiWCD
.|.||. .     |     .. ...|||| | |.||.. .|.|  .|| |... | | . | ||||            ..    |. . | |.||. ...
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.lll

DYLVRSFYLKNL-RTSETRTVTQFHFLSWPHMGVPAQAkaLLDFRRKVNKsyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREID-------I
||..| ..|..|  ..|.|.|...|...|| .||| .|  ||.. . ...      . |..|| ||| .|||....|.|.|..... .   |       .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

AATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
....|.||.||.|.| | .|..|...|..| . .
eeaveelraqrpgavqteeqylflyeallellrs

0036282 (Phosphotyrosine protein) phosphatases II 1014-1215 1e-32 108.6 In-house 3-163 (174) alignment
Range on Protein: 1014-1215
Range on HMM: 3-163/174.0
DYVNASTItDHDPRAPAYVAAQGPLPstlahFWQMIWEQGAVVIVALCRLQENGEVACARYWPEegaevyhiyevhlvsehiwcddylvrsfylknLRTS
|| ||| . |   . | ..| ||||.     ||.|..|.|  ..| |....|.| . | .||||                                ||..
dyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

ETRTVTQFHFLSWPHMGVPAQAKaLLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNkgAREIDIAATLEHLRDQRAGVVATRQQFEF
..|.. |...| || .|||  .. ||.| . |.. .   ...|..|| ||| ||||. ....|.| ..    . .|. ...  || || |.| | .|..|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrf

VL
. 
ly

0051082 (Phosphotyrosine protein) phosphatases II 1014-1218 5.2e-28 92.9 In-house 4-149 (151) alignment
Range on Protein: 1014-1218
Range on HMM: 4-149/151.0
DYVNASTITDHdprapaYVAAQGPLPstlaHFWQMIWEQGAVVIVALCRLQENGevACARYWPEEGaevyhiyevhlvsehiwcddylvrsfylknlrts
|| |.| .|..      . . .|||.    .|.....|.|  .|| |. ..|.|   |..|.||.|                                  
dyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

etRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsyrgRRSCPIVVHGSAGAGRTGVYILLDLVLERmnkgareIDIAATLEHLRDQRAGVVATRQQFEF
  ..|.....|.||  |.|   .|.|.| .....     .. |..|| ||| ||||. ..|.|.|..       ......||..| .| ||| . ||| |
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflf

VLMAV
.|.|.
qlfal

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1029-1222 5.9e-16 53.1 In-house 82-276 (312) alignment
Range on Protein: 1029-1222
Range on HMM: 82-276/312.0
PAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPE-------EGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQF
  .|..|||| .| .||||.    |.. |. || . |.|   ||.|  .       |   ||  |   .       |    | . .    | .   . ..
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhy

HFLSWPHMGVPAQAKALLDFRRKVNKSYRgrrscPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 . |||  |.|    . | .   |.|  .     |.. | ||| ||||  .|.. ..  . .  |  ..  ..  || .||  | .  |. ..| .| | 
qwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrh.prkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

V
.
l

0049260 (Phosphotyrosine protein) phosphatases II 1030-1215 5.7e-32 105.9 In-house 10-143 (152) alignment
Range on Protein: 1030-1215
Range on HMM: 10-143/152.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWpeegaevyhiyevhlvsehiwcddylvrsfylknlrtsetrtvtQFHFLSWPHM
...|.|||.| |||.||.|..|.|. .|| |..|.|.|.. |..|.                                            |...| || .
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDh

GVPAQAKALLDFRRKVNKSyRGRRSCPIVVHGSAGAGRTGVYILLDLVLermnkgaREIDIAATLEHLRDQRAGVVATRQQFEFVL
|||  .  ||.. . ..|  . ....|..|| ||| ||||......|.|       . ...  .....| .| |.| . .| .|..
gvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1030-1214 2.9e-24 80.4 In-house 6-196 (199) alignment
Range on Protein: 1030-1214
Range on HMM: 6-196/199.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIW-CDDYLVRSFYLKNLRTS--ETRTVTQFHFLSW
 |.|.| ||  |.| ||||.|| |.  || .   | | |.  . |||   . . .   . .... |    || . .. | |  |.   || .... | ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PHMGVPAQAK--ALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNK-GAREIDIAATLEHLRDQRAGVVATRQQFEFV
     |  |    ..   |.| | |   . .|..|| | | | |||.. ||. .   ..  .  .|.      ||. | |.... |...|.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1030-1214 3e-24 80.3 In-house 5-195 (198) alignment
Range on Protein: 1030-1214
Range on HMM: 5-195/198.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIW-CDDYLVRSFYLKNLRTS--ETRTVTQFHFLSW
 |.|.| ||  ||| ||||.|| |.  || .   | | |.  . |||   . . .   . .... |    || . .. | |  |.   || .... | ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PHMGVPAQAK--ALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNK-GAREIDIAATLEHLRDQRAGVVATRQQFEFV
     |  |    ..   |.| | |   . .|..|| | | | |||.. ||. .   ..  .  .|.      ||. | |.... |...|.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1030-1214 8.4e-24 78.8 In-house 91-273 (301) alignment
Range on Protein: 1030-1214
Range on HMM: 91-273/301.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI--YEVHLVS-EHIWCDDYLVRSFYLKNL-RTSETRTVTQFHFLS
 ..|.||||..|   || |.       || |..  |. |  |. | | . .|  .|  ....... |.|  ..   |.. ...  .  .||||| . . .
rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqyse

WPHMGVPAQAKALLDFRRKVNKSYRgrrscPIVVHGSAGAGRTGVYILLDLvLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFV
|.. |||     | |.   | || .     ||||| ||| ||.  .|  .  | |  .  ..|... .|.|||..|   | |..|. ..
wtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigtey.lareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1037-1222 8.7e-17 55.5 In-house 99-288 (302) alignment
Range on Protein: 1037-1222
Range on HMM: 99-288/302.0
PLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEV--YHIYEVHLVSEHIWCDDY------LVRSFYLKNLRTS--ETRTVTQFHFLSW
|  |||  .| .| .    ..| || . |..|  || |. ..  ..  .  | |. || .   ...       . .  .|| ..     .||  ..| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PHMGVPAQAKALLDFRrKVNKSYRGRrscpIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
|. | |..|.. ||   |  .||.      ..|| ||| ||||  . .   ..   |  .  |..  .  .|. | | | . ||  ..|. |.  .
pdhGapkeaytaldil.kfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl

subfamily_hpo-7_pd Subfamily hpo-7 1039-1220 5.1e-19 63.2 In-house 44-225 (263) alignment
Range on Protein: 1039-1220
Range on HMM: 44-225/263.0
PSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCdDYLVRSFYLKN-LR-TSETRTVTQFHFLSWPHMGVPAQAK
  |.. |.|.|  ... |.| ||  .|.| . | .|.| |  |   . .| ... ..   | |...  | . |    .|.||... .  |..   | .|.
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelar

ALLDFRRKVNKSyRgrrscPIVVHGSAGAGRTGVYILLDLVLERMNK-----GAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
  |   . . .| .     ..||| |.| ||.  . . .||  .| .      . |.|    ||.|| .|.. . |  |. | .. | .
eilnilkvarns.k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1041-1222 5.7e-21 69.7 In-house 40-221 (255) alignment
Range on Protein: 1041-1222
Range on HMM: 40-221/255.0
TLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYL-KNLR-TSETRTVTQFHFLSWPHMGVPAQAKAL
|...|.|.|  ... |.| || ..|.| . | .|.| |  |   . .| ... .    | ..|   .  .|    .|.||. ...  |.    | .|. .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFRRKVNKSyRgrrscPIVVHGSAGAGRTGVYILLDLVLERMNK-----GAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
|   . | .| .     ..||| |.| ||.  ..| .||  .| .      . |.|    ||.|| .|.. . |  |. | .. | . |
lnilkvvrds.k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_PTPDC1_pd Subfamily PTPDC1 1093-1214 1.4e-06 22.9 In-house 58-168 (182) alignment
Range on Protein: 1093-1214
Range on HMM: 58-168/182.0
EHIWCDDYLVRSFYLKNLRTSETRTVTqFHFLSWPHMGVPAQaKALLDFRRKVNKSYRGRrscPIVVHGSAGAGRTGVYILLDLVLERmnkgarEIDIAA
||  |   | .| .  .|     . .. .. ..|.  ||..  . .||  . |. . .      . ||  || ||||| |   ||  .      ... . 
ehasCGagleesGfsYdlealmeqgiy.vynfgwkDygvasl.eriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak......rltaek

TLEHLRDQRAGVVATRQQFEFV
... .|..|.  . ||.| |.|
aiklvrskrpksiqtreqvelv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1099-1222 1.9e-19 64.3 In-house 76-194 (440) alignment
Range on Protein: 1099-1222
Range on HMM: 76-194/440.0
DYLVRSFylknLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLeRMNKGAREIDIAATLEHLR
||.  |.    .   |.||. |.|. .||  |||  |  .| . . ||.|     . |..|| ||||||||| | .| .| |  | . .||| . .. .|
dyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsil.reakrsdqidifsfinsmr

DQRAGVVATRQQFEFVLMAVAEEV
..|  .| | .|. ||  || | .
nnrpqmvqtpeqyafvheavlegl

0048179 (Phosphotyrosine protein) phosphatases II 1100-1216 5.9e-18 60.4 In-house 31-139 (144) alignment
Range on Protein: 1100-1216
Range on HMM: 31-139/144.0
YLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRgrRSCPIVVHGSAGAGRTGVYILLDLVLermnkgAREIDIAATLEHLRD
..| ..  .   ....|...|...|.|| .|||  .. ||.| . ... ..  ...|..|| ||| ||||......|..       . ...  .|...| 
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrs

QRAGVVATRQQFEFVLM
.| |.| ...|..|.|.
rrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 1105-1218 6.5e-19 63.5 In-house 34-139 (145) alignment
Range on Protein: 1105-1218
Range on HMM: 34-139/145.0
FYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRrsCPIVVHGSAGAGRTGVYILLDLVLErmnkgaREIDIAATLEHLRDQRAGV
. | . .. ..|...|...|.|| .|||  .. ||.| . ... ..    .|..|| ||| ||||......|.|.      . ...  .||..| || |.
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpga

VATRQQFEFVLMAV
| . .|..|.....
vpnpgqlrflyefe

PTPc_DSPc_SM00012 1117-1220 9.6e-28 91.8 In-house 1-105 (105) alignment
Range on Protein: 1117-1220
Range on HMM: 1-105/105.0
TVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRR-SCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVL
||...|...||..||| .....|.. |.|.|... .  | |.||| |||.||||....||..|....|. .|.||  ....||.||.|.| | .|. |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

MAVAE
.|..|
ralle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1143-1217 4.7e-09 30.4 In-house 251-339 (350) alignment
Range on Protein: 1143-1217
Range on HMM: 251-339/350.0
RKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLE------RMNKGAREIDIA--------ATLEHLRDQRAGVVATRQQFEFVLMA
   .. .   || ||.|| ||| ||||... || .|.       ..|  |..| |         .. .|| ||  .| . .|| |.  |
lfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1147-1191 3e-06 20.8 In-house 258-305 (349) alignment
Range on Protein: 1147-1191
Range on HMM: 258-305/349.0
KSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLE---RMNKGAREIDIA
. .   .. ...|| ||| |||||.. |||.|.    ...    |.. 
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklq

subfamily_CG42327_pd Subfamily CG42327 1152-1218 2.7e-12 41.0 In-house 245-311 (319) alignment
Range on Protein: 1152-1218
Range on HMM: 245-311/319.0
RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAV
 .  |.||| | |.||||. |  |. ......  | .||  .. ..| .||  | |..|.||.   .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

Phage_Nu1 Phage DNA packaging protein Nu1 1192-1235 8.5e-07 15.0 Pfam-A 94-138 (164) alignment
Range on Protein: 1192-1235
Range on HMM: 94-138/164.0
ATLEHLRD-QRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSG
|. . |.  ..   |.  ....|||  ||.|. .||. .| ..  
adaqeLknakekkevvetelvtfvLsRvaaeiasiLdgiPlsvqr