Gene CG7956 in Drosophila melanogaster

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP053_AA protein Get Run
DmelP053_AA_256-564 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 49-575 2.3e-194 639.2 In-house 4-514 (951) alignment 
Range on Protein: 49-575
Range on HMM: 4-514/951.0
HGIVGVISLPNVYEPHLVVVKEASAVGVLYP-----PHLVYKIKSICILS---ADDPDTDLPNCTKHTKSNQSTPTHSVSTSNNNNASvpssgggsskst
 |..| |.| . .| .||.|.|.|..|.|.       . |..|.... |.   .| ..... .||.... .... ...|.|.......            
ygvigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldlsekdskelekeectgliglielegkiivatiegkskv............

klfegMNKTWGAVKSAGNTIknttqqaanlatKQVKSSVGIREPRHIERRITEELHKIFDEtDSFYFSFDCDITNNLQRHEAKSEESQSQP-DERFFWNK
     .||.| .........            .| |..   .| ...|.|..|||.|.... .|||.| |.|.||.||............  ||||||||
.....nnkkwdlididssgy............lqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddwderFfWNk

HMIRDLINLNDKT---WILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPG
....||||..||.   ...|.||||.......| .....|.|.|||||.|||||.||||.|..||.||.||||.|||.....|||||.|||||..|.|.|
fllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsg

YKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDAVGPEAGAMGF
.||.|.....| ..|||.||. ||...|..||.|.||||..|...||....||.... ||.........||||....|..|||||.||...  |. ..|.
kkykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgy

HWRDQRG-MICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIP-EQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISG
...|... .|..||.|||.||.||||||||||.||.|||||.|| ||||  | ..|. |.|.. .. |||.|||.||||||||||||||.||.||||..|
fsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaG

MMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLLRAEDLQE
..|||..|..|....||.|..||..|||..|.| ..|. . 
vlkdgyksvsryylnnfkdkyrqkvidlllGklpkqevvel
Sac_COG5329 49-573 3.6e-131 430.2 In-house 59-525 (1070) alignment 
Range on Protein: 49-573
Range on HMM: 59-525/1070.0
HGIVGVISLPNV-YEPHLVVVKEASAVGVLYPPHLVYKIKSICILSADDPDTDLPNCTKhtksnqstpthsvstsnnnN---------Asvpssgggssk
| |.||. | .. ..  | |. ..| |.  .| . .|||  ....| .. . |  .. .                   .                     
heiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeies...................deasteklrse...........

stklfegmnktwgavksagntiknttqqaanlatkqvkssvgireprhierritEELHKI--FDETDSFYFSFDCDITNNLQRH-EAKSEESQSQPDERF
                                                      . ...    . ..||||| | |||| ||.. . . | |  . ||.|
......................................................hpcselkkLlsngsFYfStdfditntLqkrlkeelelsvdtadeef

FWNKHMIRDLINLNDK------------TWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQ
.||. ....||| ..|             .. ..|.||..  .  ....  .|.|.|||| .|||||. .||||..||.||.||||||.    .  ||||
mwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQ

VRGSVPIYWSQ-PGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSA
||||.||.|.|  .  . |. .  | . .||.||. ||.|  | || | ||||......|. .  .|  |. ....  . ...||||  .. ..|..|. 
vRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkk

LIDAVGPEAGAMGFHW--RDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIG-KAVLESQLVKLGLSPPYTPipeQLKSPFMVLWANNGDIISRQYAGTNA
|.. .  ..  .|..     .  .|  |..|||.||.||||||||.|. |. ...|| .      |  ..    .. . .  |||.||| ||..| ||.|
LlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde...dflqklneLWadnGDaisqiYTGtga

LKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLLRAEDL
||...||.| | |.| ..| ..|. |..| || |  .| .|||. |.|  .|..
lkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeav
Syja_N SacI homology domain 49-419 1.6e-97 317.5 Pfam-A 2-319 (319) alignment 
Range on Protein: 49-419
Range on HMM: 2-319/319.0
HGIVGVISLPNvyEPHLVVVKEASAVGVLYPPHLVYKIKSICILSADDPDTDLPNCTkhtksnqstpthsvstsnnnnasvpssgggsskstKlfegmnk
.||.|.|.| .  | .|.|..... |. ... | .|||||. ... .. ...   ..                                   .       
ygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie...................................e.......

twgavksagntiknttqqaanlatkqvkssvgiR--EPRHIERRITEELHKIFdETDSFYFSFDCDITNNLQRHEAKSEESQ----------SQPDERFF
                                 .  | .. |... ..|.|.. ...|||||.|.|.|..|||.. |.||..          ...||||.
.................................ekeeeekeeekllkllkkll.ssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFv

WNKHMIRDLINLN--DKTWILPIIQGFMQVENCVIG-NECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSF----RHHQLSFTQVRGSVP
||......||.|.  .. |.||.||||.. ... .  .. ..|.|.||||..||||||.|||.|..||.||.||||||.|.    ... .||.|.|||||
WNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvP

IYWSQ-PGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKL-----NNDRLIYVTFDFHDYCRGMRFEN
..|.| ......|.....|   ..|.||..||.| .. ||....|||.|..|.|| ...||.... ||     ....| |..||||  |.|..|||
lfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
Syja_N SacI homology domain 49-419 1.6e-97 317.5 In-house 2-319 (319) alignment 
Range on Protein: 49-419
Range on HMM: 2-319/319.0
HGIVGVISLPNvyEPHLVVVKEASAVGVLYPPHLVYKIKSICILSADDPDTDLPNCTkhtksnqstpthsvstsnnnnasvpssgggsskstKlfegmnk
.||.|.|.| .  | .|.|..... |. ... | .|||||. ... .. ...   ..                                   .       
ygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie...................................e.......

twgavksagntiknttqqaanlatkqvkssvgiR--EPRHIERRITEELHKIFdETDSFYFSFDCDITNNLQRHEAKSEESQ----------SQPDERFF
                                 .  | .. |... ..|.|.. ...|||||.|.|.|..|||.. |.||..          ...||||.
.................................ekeeeekeeekllkllkkll.ssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFv

WNKHMIRDLINLN--DKTWILPIIQGFMQVENCVIG-NECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSF----RHHQLSFTQVRGSVP
||......||.|.  .. |.||.||||.. ... .  .. ..|.|.||||..||||||.|||.|..||.||.||||||.|.    ... .||.|.|||||
WNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvP

IYWSQ-PGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKL-----NNDRLIYVTFDFHDYCRGMRFEN
..|.| ......|.....|   ..|.||..||.| .. ||....|||.|..|.|| ...||.... ||     ....| |..||||  |.|..|||
lfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
subfamily_SAC1_pd Subfamily SAC1 182-568 1.4e-133 436.9 In-house 59-454 (458) alignment 
Range on Protein: 182-568
Range on HMM: 59-454/458.0
REPRHIERRITEELHKIFDeTDSFYFSFDCDITNNLQRHEA------KSEESQSQPDERFFWNKHMIRDLI-NLNDKTWILPIIQGFMQVENCVIGNECF
 | .. |.. .. |..... ...||||.. |.|| |||.|       |....  . |||||||||...||  . . ...|||.|.||........ .. .
eeqkkeekeylkllelvlk.setfYfsytydltnslqrlekvtsaalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakei

TLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGY-KYRPPPRLDrGVAETQQAFELHFTKELETYGRVCIV
...|.|||| .|||||| .||||..||.||.||||||... ..  || |||||.|..||| .  ||.| ..|    .....||. |. .. |.||   .|
kfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqielygenvlv

NLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDAVGPEAGAMGFHWRDQRG-MICNQKSVFRVNCMDCLDRTNVVQTAIGK
|||.| |.||..|.||.. | .||. .. ||.||||. || ||.. .. ||| . .|   .|. ...... .. .||.|.| ||.||||||||||. ...
nLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllar

AVLESQLVKLGLSPPYTP---IpEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLL
 ||..|| .||.    .      ..|.. |  |||.|.| .| ||||| ||| |.|||| |. .|...||.||. |....||.| .||  |||. |...
evLqkqleslgvlateskleds.aeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyr
subfamily_Synaptojanin_pd Subfamily Synaptojanin 182-572 2.5e-88 288.4 In-house 54-441 (754) alignment 
Range on Protein: 182-572
Range on HMM: 54-441/754.0
REPRHIERRITEeLHKIFDeTDSFYFSFDCDITNN--LQRHeAKSEESQSQPDERFFWNKHMIRDL--INLNDKTWILPIIQGFMQVENCVIGNECFTLA
|.  . | ||.| |.|..  ...||||   | ...  |... |. ...... |.|||||. .   |   ..| . |.|... | ...    .|..    |
rseasdedriie.lkklla.sgtfyfsssadsasrldlsls.aqrrkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaa

LVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYR-PPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLV
|.|| |  |||||.. |||...|| ||.|||||.... .. .|| |.|||||..|.||| .      .| ||.. .. ||. |...  |.||.|.||||.
lisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnll

EQSGKEKTIGDAYADHVIKLNN-DRLIYVTFDFHDYCRGMRFENVSALIDAVGPE-AGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAV
 . . |... .|. .|  . .  . . .|.||.|  ..| . |... |.. .  .    ..|.   .. .  .|. | ||||.||||||| |||..| .|
GskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgkevekeqtGvlrvnClDCldrtnavqtvlglev

LESQLVKLGLSPPYTpIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDytrtgeRKiSGMMKDGMNSANRFFIQNFADSFRQCIIDLMQ-GQLLRAED
||.||  |.||     . ....  |  || .||| ||. |||| ||.|.       | .. .|||  | .| . .|| || .|  |||.  |. .. | 
lekqlealklsskes.vvsrfeevfkslWsknGdeiskiyaGtgalegk......ak.vsklkdgarsvartiqnnfldsskqeaidllllgntyveel
subfamily_FIG4_pd Subfamily FIG4 190-568 1.9e-64 209.0 In-house 127-542 (569) alignment 
Range on Protein: 190-568
Range on HMM: 127-542/569.0
RITEELHKIFDETDSFYFSFDCDITNNLQRHEA---------KSE--------ESQSQPDERFFWNKHMIRDLINLNDK-TWILPIIQGFMQVENCVIGN
    .| |  | |  ||||.  |.|. ||             |.|         .... .|.| ||....  | .  .. .|.| || ||.. ..  .  
arylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlg

ECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQIL------SF-RHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAET-QQAFELHFTKE
.  ...|..|||.. ||.|. .|||..||..||.||||||.      |. ...  ||.|.|||||.||||   |  . |..   |..   .|  ||| . 
ksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddl

LETYGR-VCIVNLVE---QSGKEKTIGDAYADHVIKLNN-----DRLIYVTFDFHDYCRGMRFENVSALIDAVGPEAGAMGFHW-RDQRGMICNQKSVFR
.. ||  . |.|||    .  .|...  .. . .  ||.     ..| |...|.. . .    . .. | .         |.   ...  .   |. . |
fqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivr

VNCMDCLDRTNVVQTAIGKAVLESQLVKLGL-SPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFA
.||.|||||||. | .|||  |  ||..||.   ..  .  ..   .  |. . || .. ||.|..  .   | .  .. |   .| ... .|..   |.
tnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfv

DSFRQCIIDLMQGQLL
|  .|  |.|. |.  
dadkqdainlflGvys
hSac2 Inositol phosphatase 660-770 2.7e-28 86.9 Pfam-A 7-114 (115) alignment 
Range on Protein: 660-770
Range on HMM: 7-114/115.0
TENAEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADPSSgdINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRLIELGMHQQTKIFQgSAPA
 |..|  . ..|.|..|.| . .  .|.| |...|.|.   ..|| ...|||||....|..|| ...|...||...|.... ||.|......... .   
iereelreqaiekckklvlpddeeliggWlLvsidhsn..ktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtysestlse.dkse

HLCLRLNYSVD
.|.||.||. .
nlglrinyrks