Gene Sac1 in Drosophila melanogaster

Synonym: CG9128, Dmel\CG9128, dsac1, l(3)2107, sac1, Dmel_CG9128, Sac1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP054_AA protein Get Run
DmelP054_AA_187-499 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Sac_COG5329 58-502 6e-130 426.2 In-house 58-519 (1070) alignment 
Range on Protein: 58-502
Range on HMM: 58-519/1070.0
TRRICGVLGTIHLLSCDYLLVATHRLFV-GVLNGAVVWRLAGYDIIPYIPNSFQRKENE----NYLR--------LLRQTLDTKFFYFSYRYDLTNSLQR
  .| |||| | |    .| |.|    | .| .|  . .. . |.|..  |...  |.|    ..           |.. | ...||||. .|.||.||.
aheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqk

QrEVAQSRPEVsgllQRAEQRFVWNGYVLRQF-----NCDKMEK-------FQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGH
. .  .  . |    ..|...|.|| ..|...     . .. ||       |  ... ||..  .......|   ..|.||| .|||||...|| |. |.
r.lkeelelsv....dtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGn

VANFVETEQIVEFNGQLTGFVQTRGSMPFHWHQ-LPNLRYKPRPVLVPGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREMGNPQ
|||||||||||. .   . |.|.||| |  | |   .| ...  ...  .   .|   ||..... || .. |||.. |. | || . | . ...  .|.
vanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlklsekpk

VRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYH-VFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVehasdIF
. . .||||.|......|... |.. .. .  .|| ..    .|||.| |.|||||||.||||||||.|.....| |.  .....|   ...       |
ihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde.....df

ESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKY
 .... .||||.| .| .|.|| |||..|||.|||. .||..|  .|  |.|.||| |...||.|||.|||.
lqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgkl
subfamily_SAC1_pd Subfamily SAC1 59-505 1.9e-204 670.5 In-house 5-456 (458) alignment 
Range on Protein: 59-505
Range on HMM: 5-456/458.0
RRICGVLGTIHLLSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSF-----QRKENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREVAQSRP
..|.|.||.|.|||..||.|.|..  || .|| |..|.| ..|||.  ||.     |.||...||.||...|... |||||.|||||||||...|.... 
vkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaal

EVSGLLQRAEQRFVWNGYVLRQF-NCDKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGF
. . ||.||..||.||...|... .....|.|.||.. ||..|.....|.... ...|.|||..||||| |.||.|..|.||||||||||||.. .||.|
kerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsF

VQTRGSMPFHWHQLPNLRYKPRPVLVPGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREMGNPQVRYESFDFHSECRKMRWDRLN
||.|||.|..|.| |||.|||.. |. ..|.|.|.  |..|||.|||.|| |||||.||.| .|. .|...||........|..||||.||||||||||.
vqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlk

ILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHAsDIFESIFKGVWADNADLVSLQYSGT
.|||.|..|..|.|.... ...|.|..|.||.||||||||||||||||.|||..|.. |..||||....|.|.. . .|..||..|||||| || ||.||
lLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskleds.aeletsfknlwadnadavsvqYaGt

CALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVN
.|||||||||||||..||..|| ||..||| |||.||.||||||||||||.|.
gAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrve
Syja_N SacI homology domain 61-349 3.3e-86 280.3 Pfam-A 1-318 (319) alignment 
Range on Protein: 61-349
Range on HMM: 1-318/319.0
ICGVLGTIHLLSCDYLLVATHRLFVGVLNG-AVVWRLAGYDIIPYIPNSFQR-----------KENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREV
..|.||.|.|||  ||||.|.|  |. ..|   ...    ..||   .. .            ||.|..|.||...| .. ||||| ||||.||||..| 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

AQSRPE----VSGLLQRAEQRFVWNGYVLRQF-NCD-KMEKFQLPLVLGFVSINQVQIN-GQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQ
.....|       ||.....||||| ..|... ... ..... |||. |||........ .... . .|.||||.||||| ..|| |..|.|||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVEF--N--GQLTGFVQTRGSMPFHWHQLPNLRYKPRPVLV-PGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREM-----GNPQ
||..  .  .... |||.|||.|..|.| .|| .||....    ... .|. .|||..|. ||. |.|||...|| |..|. .|..|....      . .
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

VRYESFDFHSECRKMRWD
..|..||||.||......
lkyiefDfhkeckgkkfe
Syja_N SacI homology domain 61-349 3.3e-86 280.3 In-house 1-318 (319) alignment 
Range on Protein: 61-349
Range on HMM: 1-318/319.0
ICGVLGTIHLLSCDYLLVATHRLFVGVLNG-AVVWRLAGYDIIPYIPNSFQR-----------KENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREV
..|.||.|.|||  ||||.|.|  |. ..|   ...    ..||   .. .            ||.|..|.||...| .. ||||| ||||.||||..| 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

AQSRPE----VSGLLQRAEQRFVWNGYVLRQF-NCD-KMEKFQLPLVLGFVSINQVQIN-GQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQ
.....|       ||.....||||| ..|... ... ..... |||. |||........ .... . .|.||||.||||| ..|| |..|.|||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVEF--N--GQLTGFVQTRGSMPFHWHQLPNLRYKPRPVLV-PGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREM-----GNPQ
||..  .  .... |||.|||.|..|.| .|| .||....    ... .|. .|||..|. ||. |.|||...|| |..|. .|..|....      . .
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

VRYESFDFHSECRKMRWD
..|..||||.||......
lkyiefDfhkeckgkkfe
subfamily_FIG4_pd Subfamily FIG4 62-504 7.9e-85 276.3 In-house 71-543 (569) alignment 
Range on Protein: 62-504
Range on HMM: 71-543/569.0
CGVLGTIHLLSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQ---RKENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQRE---------VA
 |.|| ...|.  ||.. |.|  |.|. | ..... . ..|.   .| .     ... ||.|...   || ||||| ||||..||              |
yGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekeka

QSRPE--VSGLLQRAEQRFVWNGYVLRQFNCDKM-EKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIV---
..| .  ..    .|...|||| ..| ...     ... | .. |||| ..... |..    .|.||| . ||.|.. || ...|.||| |||||||   
edrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivhea

----EFNGQLTGFVQTRGSMPFHWHQL-PNLRYKPRPVLVPGKDHLAACGLHFKEQIRLYGNNV-AVNLVDHK---GAEGELEATYARLVREMG-----N
      ..... |||.|||.| .|.|   .|  ||.  .     .. |  |||.. .. ||. .  .||| .|     |  |.  . . .. .      .
segsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPee

PQVRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVgQKVEHASDI
 ...| |.|..   ..   . |..| .   .   . |...  .| . . .|.|. ||||.|||||||. | ......|.  |..||...   |.|. ||.
kklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiide.sklefdsdv

FEsIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLV
 . ... .. |  | ..|||.|.   .|  | .  .. |   .|  ..| ||| | |.| ..||.|.||||.|  
vr.lleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvysp
subfamily_Synaptojanin_pd Subfamily Synaptojanin 63-504 9.8e-80 259.9 In-house 8-438 (754) alignment 
Range on Protein: 63-504
Range on HMM: 8-438/754.0
GVLGTIHL----LSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSfqrkENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREvAQSRPEVsgl
|.|| ..|     .  .|.. |    || ...| .....  ....   ..    ..|...  |.. | .. ||||   | ...|. ... || | .    
gllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrsea....sdedriielkkllasgtfyfsssadsasrldlsls.aqrrkqe...

lQRAEQRFVWNGY---VLRQFNCDkMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQT
 .  ..||.||      |..|. .  ... |... | |.|  | .  ..    .|.| | .|||||.  || ...|.|||||||||.. .. ..| |||.
.esednrffWnrslhlhlqrfgvn.cddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqi

RGSMPFHWHQlPNLRYKPRPVLVP--GKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARL-VREMGNPQVRYESFDFHSECRKMRWDRLN
|||.|  |.| | |.   . | .    .   ||   |.... . ||. | |||. .|..|  |. .. .    .. ...| . .||.|....  . . |.
rGsvPlfWeq.PGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkekle

ILIDRLAHE-QDQFGVYHvFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGvlhVGQKVEHASdIFESIFKGVWADNADLVSLQYSG
 |... ...  .......   .......|||| |.||.||||||| ||..|.   |.  |. |.   ...|..  |  || .|| .|  | | .|  | |
kllkkqlklflesasffl.skgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk...lsskesvvs.rfeevfkslWsknGdeiskiyaG

TCALKTdftrtgkRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFL-GKYLV
| ||..       ..|.. ..||. |. |   ||| |...|..|||.| |. .|
tgaleg.......kakvsklkdgarsvartiqnnfldsskqeaidllllgntyv
subfamily_INPP5F_pd Subfamily INPP5F 110-506 8.6e-110 359.3 In-house 118-510 (951) alignment 
Range on Protein: 110-506
Range on HMM: 118-510/951.0
QRKENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREVAQSRPEVSGllqraEQRFVWNGYVLRQFNCDKMEK---FQLPLVLGFVSINQVQINGQTFF
..|...  |  |.. |. . ||.|. .||||.||.. .  .|           ..||.|| . |...   . ..   | .|.. |||......|. ... 
eeklekrlleelkkllsdgsFYysldfDltntlqkrgleeksestddw.....derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvs

WSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFVQTRGSMPFHWHQLpNLRYKPRPVLVPG-KDHLAACGLHFKEQIRLYGNNVAVN
  .| ||| .|||||.  || |..|.||||||||.|....     |.| |||.|  | |  . .|||.. .    ..  .|   |||||.  ||. | ||
ltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfkeqlkkygkvvivn

LVDHKGAEGELEATYARLVREMGNPQVRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARR
|...|. | .|  .|.. .... ...| . .|||| |....... .. ||. .  |  ..|.. .  ..|..| |.|||||||.||||||||||..... 
llsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiska

SLTAVLQKLGVLHVGQKVEHasDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVN
 |   |.|||...  ....   . . . .| .|||| | .| || || ||| |.||.|.|  .|...||..|. |||||||.| .||. ||| |||   .
vlelqleklglfepessidd..eellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGklpkq

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