Gene Mipp1 in Drosophila melanogaster

Synonym: CG4123, CK2082, Dmel\CG4123, mipp1, Dmel_CG4123, Mipp1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP116_AA protein Get Run
DmelP116_AA_28-439 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0047369 Phosphoglycerate mutase-like 29-438 4.8e-65 213.4 In-house 15-436 (438) alignment 
Range on Protein: 29-438
Range on HMM: 15-436/438.0
QTRQFSSKTAYQIVKGTDIDKQYLVPGCQPQKMWIFHRHGTRLPKKSMINkasRVAELRDLIINNYQVARtkpetdalcqTDLIAIKLWKWNSsitpDMe
...... .. |  . |  .. . ...||.........|||.| | || ..   ... | .|. |.. ...           .|  .. |...     .. 
illhlgtlspyfsapgvglisldvpegcelkqvqvlfRHGaRtPtksklk...kleplwellenattyps..........gplsflndwlgpc....ga.

EYLTAQGYEDLRGTAKLYQRYYPTVltanYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQ-----------NAAHPVEIPKQDLLLR--PYDYCSSFKNV
..|| .|.|...   | . ..|.      .... . .| .|..|| .|  ||. |||. .           .. . ......| ||.  |.|.|. |...
gqLTplGreqayelGkrlrkrYglL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdel

NYKDEGSEYYKFHQsklYNDTLADISTRLGFlYTLEEADIKLMYDMCRYEQAWNVD---RNSVWCGAFLPEQITVFEYLEDLKYYYGSGYGFPENAHLNC
  ..  |. .. .    ..| |. ... |.. . |.  |.  .||.|.|. ..| .    .| .|. | ||...|.|||.||..||. |||.. . .  .
lkeflasdeflell...lkdilkrlkkllpg.lnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklagg

RLVQDLLTHLSN--------------------PVSPHVVAHFGHSTGLLTLLTALGIQKDDIKLRADNYDSL-TSRRWKSSLIDPFAANFVAVKYDCPaD
 |....|..| .                    |... ....|.| | ...||.|||. .|.. |. ...| . ..| ..|| | |.|.|.|  .|.|| .
pllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecp.s

LDREKVVFFLNQQAVQLDWCSVG---LCKWSDVLEKYKTIADADCGEYyC
 ..  | ...|.. ..|..|..|   ||...|..| .|.... |  |. |
dgeyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpgdfeel.C
0048946 Phosphoglycerate mutase-like 30-439 1.7e-66 217.9 In-house 14-410 (447) alignment 
Range on Protein: 30-439
Range on HMM: 14-410/447.0
TRQFSSKTAYQIVKGTDIDKQYlVPGCQPQKMWIFHRHGTRLPKKSMINKASRVAELRDLIinnyqvartkpeTDALCQTDLIAIKLWKW--NSSITPDM
.. .. .. |..|.|  |.. . ..||.........|||.| |.|.....   ...| . .            .  ..  ||  .. ||.  ........
llhlgtlspyfsvpgygipepv.pegcelkqvqvlfRHGaRtPtkkylkgleplldllkna............nvlelggdlsflndwkyqlkneplwpc

E-EYLTAQGYEDLRGTAKLYQRYYPTVLTanyNDTYYQFRHTDTQRTTESFKAFAEGLFGSQ--NAAHPVEIPK----QDLLLRPydYCSSFKNVNYKDE
. ..||..|.|.|.   | . ..|.. |    | . . .|..|..|| .|  ||. |||. .  . ..|. |.     .| ||.|  .|  ||.. .|  
glgqLTplGreqlyelGkrlrkrYlgllp...npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp..sCpafkellkkel

GsEYYKFhqskLYNDTLADISTRLGfLYTLEEADIKLMYDMCRYEQAWNvdRNSVWCGAFLPEQITVFEYLEDLKYYYGSGYGFPENAHLNCRLVQDLLT
  |..|.    |....|. ... ||  ..|   |.  .||.. || |..    | .|. | ||...|.|||.||..||. ||| . . .  . |....|.
a.eelke....llkellerlkkllg.glnltlsdvydlydlllyetaih..glsplcslftpeelevleyladlefyyeygygdelarlaggpllneila

HLSNPVSPH--VVAHFGHSTGLLTLLTALGIQKDDIKLRADNYDSltSRRWKSSLIDPFAANFVAVKYDCPAD---LDREKVVFFLNQQAVQLDWCSVG-
.|.. .|..  ....|.| | ...||.|||. .|.. | |||..   .| ..|| | |.|.|.|  .|.||..    ..  | ...|.. ..|..|..| 
rledaisgdsklylyfaHdttiaallsaLglfddelplpadnlpf..nrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgp

--LCKWSDVLEKYKTIADaDCGEYyCR
  ||...|..| .|.. . |. .. | 
gglCplddFkellkkflp.dwekl.Cg
0049059 Phosphoglycerate mutase-like 30-438 3.7e-64 210.2 In-house 15-434 (435) alignment 
Range on Protein: 30-438
Range on HMM: 15-434/435.0
TRQFSSKTAYQIVKGTDIDKQYLVPGCQPQKMWIFHRHGTRLPKKSMINKasrVAELRDLIINNYQVARtkpetdalcqtdliaiklwkW----------
....  .. |  ..|   .   ...||.........|||.| |....|.|   .  | .......  ..                    .          
llllgtlspyfsapgvfgisldvpegcelkqvqvlfRHGaRtPtsklikk...lealwekllslltypn....................gplsflndwny

NSSitpdmEEYLTAQGYEDLRGTAKLYQRYYPTVltanYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQ----------NAAHPVEIPKQDLLLR--PYD
.        ..||..|.|... ..| . ..|.      ||.. . .| .|..|| .|  ||..|||. .          |  .|| |. .| .    |||
plg.....ageLTplGreqayelGkrlrkrYgfL....ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtlpyd

YCSSFKNVNYKDEGSEYYKFHQSKLYNDTLADISTRLGflytLEEADIKLMYDMCRYEQAWNVDRN---SVWCGAFLPEQITVFEYLEDLKYYYGSGYGF
.|. |... ...  |. .. .  . . . |.... .||    |   |.  .||.| |. ...   .   . .|. | .|.. |.||| || .||. ||| 
scpafdellkellasdeflelflerilkllqellpglg....ltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygd

PENAHLNCRLVQDLLTHLSNPV--------------------SPHVVAHFGHSTGLLTLLTALGIQKDDIKLRADNYDSLT-SRRWKSSLIDPFAANFVA
. .    . |....| .| . .                    .. ....|.| | ...||.|||. .|.. | |||... . .| ...| | |.|.|.| 
eiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvf

VKYDCPADlDREKVVFFLNQQAVQLDWCSVG---LCKWSDVLEKYKTIADADCGEYyC
 .|.|| . ..  | ...| . ..|..|..|   ||...| .| .|.. . |  .. |
Elyecpdg.neyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.C
subfamily_MINPP1_pd Subfamily MINPP1 31-440 7.2e-129 422.3 In-house 4-416 (420) alignment 
Range on Protein: 31-440
Range on HMM: 4-416/420.0
RQFSSKTAYQIVKGTDIDKQYLVPGCQPQKMWIFHRHGTRLPKKSMINKasrVAELRDLIiNNYqVARTKpETDALCQTDLIaiklwkWNSSITPDMEEY
....|||.|. ||.....|.... ||...|..|..|||||.|.||.|.|   ..| .. | .|| ..... ........||       .|.... ..|..
kflgsktpyysvkanydikkeaeegCklvklqiiaRHGtRypskskikk...iqetleki.kny.seqld.gklsilnedle......snleyeteleks

LTAQGYEDLRGTAKLYQRYYPTVLTANYNDTYYQFRHTDTQRTTESFKAFAEGL------FGSQNAAHPVEIPKQ--DLLLRPYDYCSSFKNVNYKDEGS
|.|||.|.|...|| ..|..|......||.....|..|...||..|..||||||      .|...... .|| .|  | |||..|.|...|| ..|.| .
lvaqgqeeleelakrlarrfpalfeevynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqesdklLrffdsCkkyknkvkkneln

EYYK--FHQSKLYNDTLADISTRL---GFLYTLEEADIKLMYDMCRYEQAWNvDRNSVWCGAFLPEQITVFEYLEDLKYYYGSGYGFPENAHLNCRLVQD
....  |..|| ....|..|..||     |..|.|.||. |...|.||.|.. ....|||  | .......|||||||.|| .|||.  |....|.|..|
lkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaik.gisnvWcslfekdelleleYledLknyykegyGyeinysiscpLlnd

LLTHLSNPVSPHVV---AHFGHSTGLLTLLTALGIQKDDIKLRADNYDSLTSRRWKSSLIDPFAANFVAVKYDCpaDLDREKVVFFLNQQAVQLDWCSVG
....|.. .. ..     .|.|...||.||..||..||..||.|.||..|..|...||.|.|.|||...|.|||  . |. ||...||...|.|..|| |
ivkllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydC..skdqykvlvllnekvvkletcseg

--LCKWSDVLEKYKTIADADCGEYYCRT
  .|...|..|.||.|.|. . |..|..
eifCelqdfkeiykkivdncdleklCev
0046349 Phosphoglycerate mutase-like 53-432 1.5e-61 201.8 In-house 2-385 (409) alignment 
Range on Protein: 53-432
Range on HMM: 2-385/409.0
VPGCQPQKMWIFHRHGTRLPKKSminkasrvaelrdliinnyqvartkpeTDALCQTDLIAIKLWKWNSsitpdmeEYLTAQGYEDLRGTAKLYQRYY--
||||.........|||.| |.|.                           ...|.. ..| .. ....        ..||..|.|... . | . ..|  
vPgceLkqvqvlfRHGaRtPtkk...........................lsflpnwpginwtngpcga.......gqLTplGreqayelGkrlrkrYvd

PTVLTAN--YNDTYYQFRHTDTQRTTESFKAFAEGLFGS-------------------QNAAHPVEIPK----QDLLLRPYDYCSSFKNV--NYKDEGSE
.  |  |  || . . .| .|..|| .|  ||..|||.                      . . | |.     .| ||.|...|. ....  .... .||
lgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslse

YYKFH---------QSKLYNDTLADISTRL-----GFLYTlEEADIKL-MYDMCRYEQAWNVDRNsVWCGAFLPEQITVFEYLEDLKYYYGSGYGfPENA
...|.         ... . |.|  .. ||     |. .|    |. . .||.. ||.|.. .    ||. | ||.. |..|| || |||. |.| . . 
vleflvdealldlelldetkdllkklaerlnselpglnlt.dpldvasllydtllyetahglplp.pwcdlftpeelkvlayladleyyylygsg.elak

HLNCRLVQDLLTHLSNPV----------SPHVVAHFGHSTGLLTLLTALGIqkddiklradnydslTSRRWKSSLIDPFAANFVAVKYDCPADlDREKVV
   . |....|..| . .          .. ... |.| | ...||.|||.               . | ..|| | |.|.|.|  .|.|| | ..  | 
laggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLgl...............fdrlfrssdippyasnlvfElyecpsd.geyyVr

FFLNQQAVQLDWCSVGlCKWSDVLEKYKTIADA----D
...| . ..| .|..| |..|...| .| ...     |
vlynggplplpgcgeg.cplsefkellkkrlpgcgltd
0048439 Phosphoglycerate mutase-like 53-428 7.7e-56 183.1 In-house 4-389 (391) alignment 
Range on Protein: 53-428
Range on HMM: 4-389/391.0
VPGCQPQKMWIFHRHGTRLPKKSMINKASRVAELrdliinnyqvartkpetdalcqtdliaiklwkwNSSITPDMEEYLTAQGYEDLRGTAKLYQRYY--
..||.........|||.| |..|..||   . ..                                 .  . | . ..||..|.|.|. . . . ..|  
pagcelkqvqvlfRHGaRtPtssypnkldpllnk.................................llpngpcglgeLTplGreqlyelGrrlrkrYvd

PTVLTANY--NDTYYQFRHTDTQRTTESFKAFAEGLFGSQNA--AHPVEIPKQDLLLRP--YDYCSSFKNVNYKDEGSEYYKFHQSKLYNDTLADISTRL
.  |  .|  | . . .|..|..|| .|  ||..|||. ..    .....   |.|| |  ...|. ..    .|  |....|. |. ..   . ..  |
lgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvl

GFLYTLEeaDIKLMYDMCRYEQAWNVDRN---SVWCGAFLPEQITVFEYLEDLK-------------------------YYYGSGYGfPENAHLNCRLVQ
|...|.|  |.....|.|..| |..   .   | .| .|  . . ..||...|.                         |||  |.| . .    . |..
glnltae..dvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg.eiaklaggplln

DLLTHL--SNPVSPHVVAHFGHSTGLLTLLTALGIQKDDIKLRADNydsltsrrwkssliDPFAANFVAVKYDCPADlDREKVVFFLNQQ----------
..|..|  ..| .| ....|.| | ...||.|||. .|.. |.||.               |.|.|.|  .|.|| | ..  | ...|..          
eilddlvangpsdpklylyfaHdttiaallsaLglfndtlplpadl..............ppyasnlvfElyecpsd.geyyVrvlynggtldlprdltl

----------AVQLDWCSVG---LCKWSDVLEKYKTI
           ..|..|. |   ||...| .| .|..
ldldefllrlvlplpgcgsgpgglCplddFvelvkkr
0049226 Phosphoglycerate mutase-like 57-438 2.2e-56 184.5 In-house 2-340 (342) alignment 
Range on Protein: 57-438
Range on HMM: 2-340/342.0
QPQKMWIFHRHGTRLPkksminkasrvaelrdliinnyqvartkpetdalcqtdLIAIKLWKWNSSITPDMEEYLTAQGYEDLRGTAKLYQRYYPTVLTA
.........|||.| |                                      |  ..|. .|    . . ..|| .|.|...  .. . ..|.. |  
kLkqvqvliRHGdRtP......................................lakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllps

NYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQNAA----------HPVEI--PKQDLLLRP-YDYCSSFKNVNYKDEGSEYYKFHQSKlYNDTLADISTR
.|| . . .| .|..|| .|  ||. |||. ...            |...  ...| ||.. ||.|  |...  .   ||... . .. . |.| ..| .
tynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlflee.ildllkklskl

LGFLYTlEEADIKL-MYDMCRYEQAWNVDRNSvWCGAFLPEQITVFeYLEDLKYYYGSGYGFPENAHLNCRLVQDLLTHLSN----PVSPHVVAHFGHST
||. ..    |.   .||...||.|....  . ||. |..|.. .. | .||.|||| ||| . . .  . |....| .|..    | .. ....|.| |
lglnls.tlsdvadtlydlllyelahglplpp.wcslftleelkal.yaldllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfahdt

GLLTLLTALGIQKDDIKlradnydsltsrrwksslidPFAANFVAVKYDCPadlDREKVVFFLNQQA------VQLDWCsVGLCKWSDVLEKYKTIADAd
 ...||.|||. .|..                     |.|.|.|  .|.|.   ..  | ...| .       ..|..|  |||......| .|....  
tiaallsalglfddqlP....................pyasnlvfElyecd...geyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkkflpg.

CGEYYC
. |..|
dfeelC
0053031 Phosphoglycerate mutase-like 60-433 2.8e-56 184.3 In-house 5-336 (342) alignment 
Range on Protein: 60-433
Range on HMM: 5-336/342.0
KMWIFHRHGTRLPkksminkasrvaelrdliinnyqvartkpetdalcqtdLIAIKLWKWNSSITPDMEEYLTAQGYEDLRGTAKLYQRYYPTVLTANYN
......|||.| |                                      |  ..|. .|  ..|.  ..|| .|.|... . . . ..|.. |  .||
qvivlvRHGaRtP......................................lskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstyn

DTYYQFRHTDTQRTTESFKAFAEGLFGSQNAA----------HPVEI--PKQDLLLRP-YDYCSSFKNVNYKDEGSEYYKFHQSKlYNDTLADISTRLGF
 . . .| .|..|| .|  ||..|||. ..             |...  . .| ||.| ||.|  |...  ..  ||..| . .. | . |. .| .||.
pdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkeller.ylellqklskglgl

LYTLEEADIKLMYDMCRYEQAWNVDRNSvWCGAFLPEQITVFeYLEDLKYYYGSGYGFPENAHLNCRLVQDLLTHLSN----PVSPHVVAHFGHSTGLLT
 ..  .  .  .||.. ||.|.. .  . ||. |..|.. .. | .||.|||| |.| . . .  . |....| .| .    | .. ....|.| | ...
tlsdlldlvsdlydlllyelahglplpp.wctlftleelkal.yaldllyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdttiaa

LLTALGIQKDDIKlradnydsltsrrwksslidPFAANFVAVKYDCPadlDREKVVFFLNQQ------AVQLDWCSvGLCKWSDVLEKYKTIADADC
||.|||...|..                     |.|.|.|  .|..|   ..  | ...|..       ..|..|. |||..|...| .|...  | 
llsaLglfddqlP....................pyasnlvfElyedp...geyyVrvlynggtlseplvlplpgcd.glcplsefkelvkkllpgdf
His_Phos_2 Histidine phosphatase superfamily (branch 2) 61-388 2.5e-24 78.8 Pfam-A 5-335 (347) alignment 
Range on Protein: 61-388
Range on HMM: 5-335/347.0
MWIFHRHGTRLPKKSMINKASRVAELRDLIinnyqvartkpetdalC---------------QtdliaiklwkWNSSITPDMEEyLTAQGYEDLRGTAKL
. . .||| | ||...  .      .  |                                 .               .  ... || .| . ..  .. 
vvvviRHGdRtPkqkfkksvtsekfisllk................lknvlekkghfpgtkrk..........eklqlilkwgg.lThsGrkqaeelGeq

YQRYYPTVLTANYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQN--------------AAHPVEIPK-----QDLLLRPYDYCSSFKN--VNYKDEGSEY
. . ||  |  ...   . .| .. .|. .| .|||.||.| ..               |  .....     ..||.. .. |  |..  ...... .| 
lrqrYpgllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvel

YKFHQSKLYNDTLADISTRLGFLYTLEEADIKLMYDMCRYEQAwnVDRNSVWCGAFLP--EQITVFEYLEDLKYYYGS-GYGFPENAHLNCRLVQDLLTH
 ....... ..  . .|  ..   .|.  .    .... .|.      .| ..  .    ..   ...||||...|.  |.| .|. .    |...|| .
vnklkkvmdenlakrlsalctgednllfkerweklfreffeee..kfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkk

LSNPVSPHV-------VAHFGHSTGLLTLLTALGIQKDDIKLradnydsltsrrwkSSLIDPFAANFVAVKYDC
. . ....        .. |.| . ..|||.|||..... ..              .|   |.|.. |   | .
ilsdleetqpsrhaklrlyfthDshiytllnaLgleekiare..............aspelpyasqivfelyed
His_Phos_2 Histidine phosphatase superfamily (branch 2) 61-388 2.5e-24 78.8 In-house 5-335 (347) alignment 
Range on Protein: 61-388
Range on HMM: 5-335/347.0
MWIFHRHGTRLPKKSMINKASRVAELRDLIinnyqvartkpetdalC---------------QtdliaiklwkWNSSITPDMEEyLTAQGYEDLRGTAKL
. . .||| | ||...  .      .  |                                 .               .  ... || .| . ..  .. 
vvvviRHGdRtPkqkfkksvtsekfisllk................lknvlekkghfpgtkrk..........eklqlilkwgg.lThsGrkqaeelGeq

YQRYYPTVLTANYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQN--------------AAHPVEIPK-----QDLLLRPYDYCSSFKN--VNYKDEGSEY
. . ||  |  ...   . .| .. .|. .| .|||.||.| ..               |  .....     ..||.. .. |  |..  ...... .| 
lrqrYpgllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvel

YKFHQSKLYNDTLADISTRLGFLYTLEEADIKLMYDMCRYEQAwnVDRNSVWCGAFLP--EQITVFEYLEDLKYYYGS-GYGFPENAHLNCRLVQDLLTH
 ....... ..  . .|  ..   .|.  .    .... .|.      .| ..  .    ..   ...||||...|.  |.| .|. .    |...|| .
vnklkkvmdenlakrlsalctgednllfkerweklfreffeee..kfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkk

LSNPVSPHV-------VAHFGHSTGLLTLLTALGIQKDDIKLradnydsltsrrwkSSLIDPFAANFVAVKYDC
. . ....        .. |.| . ..|||.|||..... ..              .|   |.|.. |   | .
ilsdleetqpsrhaklrlyfthDshiytllnaLgleekiare..............aspelpyasqivfelyed
subfamily_ACP2_pd Subfamily ACP2 63-353 3.9e-12 38.4 In-house 14-287 (361) alignment 
Range on Protein: 63-353
Range on HMM: 14-287/361.0
IFHRHGTRLPKKSMINKAsrvaelrdliinnyqvartkpetdalcqtdliaiklWKwNSSItPDMEEYLTAQGYEDLRGTAKLYQRYY---PTVLTANYN
.  ||| | |.... |.                                     .| .... |     ||..|...     |.... |    . |.|.||
vlfRHGdRsPlntypndk....................................yk.edew.pqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakyn

DTYYQFRHTDTQRTTESFKAFAEGLFGSQ-NA---------AHPVEI--PKQDLLLRPYDYCSSFKNVNYKDEGSEYYKfHQSKLYNDTLADISTRLGfl
 .  ..| .|..|| .|  ... |||... .            || .   ..|||||.   |  ....  . . |. .|    . ... |  .| . |  
pkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevk.klleenkelleklsestg..

Y-TLEEADIKlMYDMCRYEQA-WN-VDRNSVWCGAFLPEQITVFEYLEDLKYYYGSGYgFPENAHLN-CRLVQDLLTHLSNPVS-------PHVVAHFGH
  . .| ... ..|    |..  | .  ...    .. .   ....   .... .. .  .| . |.   |...||..... ..         ...  .|
edidlenfyq.lsdtlicerkyanelnlpewandelfekleeladkvkeaefglnnek.trelkklrgGpllnellenmkeklkceekkkklklflYSaH

STGLLTLLTALGIQKDD
 | |..|| |||| ...
DttlaalLeaLgifekk