Gene CDC14A in Homo sapiens

Synonym: cdc14, hCDC14, CDC14A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP005_AA protein Get Run
HsapP005_AA_16-159 phosphatase_domain Get Run
HsapP005_AA_178-336 phosphatase_domain Get Run
Domains
Summary
200400600MGNFLSRENKVQVISESDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKKFNSAKEAFDSPDSPCurated phosphatase domainDSPnDSPcPfam Domainsubfamily_CDC14_pd(1)0048567(2)0049772(3)0041856(4)0038934(5)Subfamily
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 17-337 4.7e-180 592.5 In-house 8-328 (328) alignment
DSPn Dual specificity protein phosphatase, N-terminal half 17-153 2.4e-63 203.0 Pfam-A 5-140 (141) alignment
0048567 (Phosphotyrosine protein) phosphatases II 17-163 1.6e-57 188.0 In-house 12-157 (157) alignment
0050432 (Phosphotyrosine protein) phosphatases II 121-324 1.3e-42 141.6 In-house 5-289 (308) alignment
0045450 (Phosphotyrosine protein) phosphatases II 124-323 1.5e-40 135.2 In-house 2-293 (307) alignment
0049772 (Phosphotyrosine protein) phosphatases II 126-333 1.6e-46 154.8 In-house 65-271 (314) alignment
0039614 (Phosphotyrosine protein) phosphatases II 127-323 5e-40 133.2 In-house 1-278 (297) alignment
0043336 (Phosphotyrosine protein) phosphatases II 137-322 2.4e-38 127.6 In-house 4-265 (278) alignment
0040438 (Phosphotyrosine protein) phosphatases II 138-322 1.6e-40 134.7 In-house 3-264 (317) alignment
0045098 (Phosphotyrosine protein) phosphatases II 152-334 3e-39 130.5 In-house 7-273 (278) alignment
0044763 (Phosphotyrosine protein) phosphatases II 160-337 1.7e-38 127.4 In-house 2-175 (178) alignment
0047943 (Phosphotyrosine protein) phosphatases II 163-323 2.3e-28 94.8 In-house 23-261 (273) alignment
0041856 (Phosphotyrosine protein) phosphatases II 165-341 4.6e-45 148.8 In-house 2-178 (182) alignment
0038934 (Phosphotyrosine protein) phosphatases II 168-328 1.4e-44 147.4 In-house 4-169 (194) alignment
0043147 (Phosphotyrosine protein) phosphatases II 168-326 5.9e-36 119.1 In-house 2-153 (172) alignment
0040439 (Phosphotyrosine protein) phosphatases II 169-322 1.1e-32 109.0 In-house 2-234 (249) alignment
PTEN_1 169-332 5.4e-32 106.2 In-house 13-191 (196) alignment
0042113 (Phosphotyrosine protein) phosphatases II 170-323 2.9e-32 107.4 In-house 1-232 (245) alignment
0036282 (Phosphotyrosine protein) phosphatases II 172-323 7.6e-32 105.8 In-house 3-159 (174) alignment
0046846 (Phosphotyrosine protein) phosphatases II 175-323 1e-29 98.9 In-house 6-162 (176) alignment
0037934 (Phosphotyrosine protein) phosphatases II 176-322 5.5e-32 106.7 In-house 34-230 (243) alignment
0048567 (Phosphotyrosine protein) phosphatases II 176-227 5.6e-07 24.1 In-house 2-58 (157) alignment
0051082 (Phosphotyrosine protein) phosphatases II 180-326 1.6e-33 110.8 In-house 7-145 (151) alignment
0051429 (Phosphotyrosine protein) phosphatases II 181-323 3.9e-21 71.4 In-house 16-214 (272) alignment
0046845 (Phosphotyrosine protein) phosphatases II 183-323 2.9e-22 74.8 In-house 73-263 (284) alignment
0051299 (Phosphotyrosine protein) phosphatases II 185-323 1.4e-21 72.6 In-house 90-275 (288) alignment
subfamily_RNGTT_pd Subfamily RNGTT 185-327 5.1e-13 43.1 In-house 14-166 (189) alignment
0036941 (Phosphotyrosine protein) phosphatases II 186-323 9.5e-20 66.5 In-house 77-266 (297) alignment
0049260 (Phosphotyrosine protein) phosphatases II 208-326 9.2e-33 108.4 In-house 20-142 (152) alignment
subfamily_PRL_pd Subfamily PRL 212-330 1.4e-20 67.8 In-house 25-147 (151) alignment
0048179 (Phosphotyrosine protein) phosphatases II 213-324 4.8e-28 93.1 In-house 21-136 (144) alignment
subfamily_STYX_pd Subfamily STYX 213-311 1.5e-06 21.4 In-house 31-135 (166) alignment
0048076 (Phosphotyrosine protein) phosphatases II 214-325 2.4e-27 90.8 In-house 22-135 (145) alignment
0048567 (Phosphotyrosine protein) phosphatases II 215-333 2.8e-37 122.4 In-house 10-138 (157) alignment
PTPc_motif_SM00404 216-327 9.7e-16 52.9 In-house 22-133 (140) alignment
subfamily_PTPMT1_pd Subfamily PTPMT1 217-315 1.8e-12 42.0 In-house 42-150 (171) alignment
DSPc Dual specificity phosphatase, catalytic domain 218-326 8e-14 46.7 Pfam-A 15-125 (133) alignment
DSPc Dual specificity phosphatase, catalytic domain 218-326 8e-14 46.7 In-house 15-125 (133) alignment
subfamily_DSP1_pd Subfamily DSP1 218-325 1.5e-10 35.4 In-house 40-146 (163) alignment
subfamily_DSP15_pd Subfamily DSP15 218-343 6.6e-09 30.0 In-house 24-147 (151) alignment
subfamily_DSP19_pd Subfamily DSP19 218-326 6.8e-09 30.2 In-house 34-141 (152) alignment
PTPlike_phytase Inositol hexakisphosphate 221-295 6e-07 24.2 Pfam-A 74-147 (149) alignment
PTPlike_phytase Inositol hexakisphosphate 221-295 6e-07 24.2 In-house 74-147 (149) alignment
subfamily_PTPRK_pd Subfamily PTPRK 223-296 7.8e-07 23.2 In-house 163-234 (314) alignment
subfamily_DSP3_pd Subfamily DSP3 226-326 1.6e-08 28.3 In-house 51-148 (162) alignment
subfamily_DSP11_pd Subfamily DSP11 230-313 7.9e-10 32.9 In-house 67-157 (178) alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 233-322 2.1e-15 51.6 In-house 73-164 (182) alignment
subfamily_DSP23_pd Subfamily DSP23 252-322 2.9e-16 54.4 In-house 61-134 (148) alignment
subfamily_PTEN_pd Subfamily PTEN 252-307 1.1e-09 33.6 In-house 89-150 (184) alignment
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 252-296 9.4e-06 19.5 In-house 199-244 (305) alignment
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 254-294 1.1e-06 22.8 In-house 194-234 (315) alignment
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 257-317 1.1e-07 25.9 In-house 200-266 (290) alignment
subfamily_PTPN12_pd Subfamily PTPN12 259-294 6e-06 20.3 In-house 194-229 (290) alignment
PTPc_DSPc_SM00012 260-298 5e-09 31.7 In-house 21-65 (105) alignment
Y_phosphatase Protein-tyrosine phosphatase 260-316 5.7e-07 24.5 Pfam-A 154-219 (235) alignment
Y_phosphatase Protein-tyrosine phosphatase 260-316 5.7e-07 24.5 In-house 154-219 (235) alignment
DSPc_SM00195 260-319 6.3e-07 24.4 In-house 179-247 (263) alignment
PTPc_SM00194 260-319 6.3e-07 24.4 In-house 179-247 (263) alignment
subfamily_Slingshot_pd Subfamily Slingshot 262-327 3.4e-08 27.0 In-house 86-149 (169) alignment
subfamily_PTPN6_pd Subfamily PTPN6 262-293 3.4e-06 21.3 In-house 217-248 (306) alignment
subfamily_DSP12_pd Subfamily DSP12 263-326 3.4e-09 31.3 In-house 73-134 (155) alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 263-322 3.3e-07 24.1 In-house 212-276 (302) alignment
subfamily_DSP8_pd Subfamily DSP8 263-326 1e-06 22.4 In-house 84-145 (159) alignment
subfamily_STYXL1_pd Subfamily STYXL1 263-327 6.6e-06 19.4 In-house 83-145 (157) alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 263-331 7.5e-06 20.1 In-house 189-261 (270) alignment
subfamily_DSP10_pd Subfamily DSP10 264-325 4.7e-09 30.3 In-house 84-143 (159) alignment
subfamily_DSP6_pd Subfamily DSP6 264-326 2.4e-06 21.1 In-house 85-145 (158) alignment
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 266-327 2.7e-07 24.1 In-house 85-144 (154) alignment
subfamily_PTPN13_pd Subfamily PTPN13 266-314 1.5e-06 22.7 In-house 196-249 (273) alignment
subfamily_DSP14_pd Subfamily DSP14 268-326 1.8e-07 25.3 In-house 79-135 (157) alignment
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 268-308 3.2e-06 19.9 In-house 62-102 (128) alignment
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 268-308 3.3e-06 19.9 In-house 61-101 (128) alignment
subfamily_VSP_pd Subfamily VSP 269-304 7e-06 20.1 In-house 125-160 (212) alignment
subfamily_LRR-DSP_pd Subfamily LRR-DSP 271-325 2e-06 21.1 In-house 196-248 (263) alignment