Gene CDKN3 in Homo sapiens

Synonym: CDI1, CIP2, KAP, KAP1, CDKN3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDKN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP008_AA protein Get Run
HsapP008_AA_26-197 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 1-168 2.7e-120 389.5 Pfam-A 1-168 (168) alignment 
Range on Protein: 1-168
Range on HMM: 1-168/168.0
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCG
||||.|||.||||||||||.|.|||||.|||||||||||||||||||||||||||||||||||||||||.||||.|||||||||||||||||||||||.|
mkppisiqasefdssdeepveeeqtpiqiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelksygiqdvfvfctrgelskyrvpnlldlyqqyg

IITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAI
|.|||||||||||||||||.||||||.|||||||||||||||||||||||||||||||||.|||||||
ivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 1-168 2.7e-120 389.5 In-house 1-168 (168) alignment 
Range on Protein: 1-168
Range on HMM: 1-168/168.0
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCG
||||.|||.||||||||||.|.|||||.|||||||||||||||||||||||||||||||||||||||||.||||.|||||||||||||||||||||||.|
mkppisiqasefdssdeepveeeqtpiqiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelksygiqdvfvfctrgelskyrvpnlldlyqqyg

IITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAI
|.|||||||||||||||||.||||||.|||||||||||||||||||||||||||||||||.|||||||
ivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
subfamily_CDKN3_pd Subfamily CDKN3 2-203 1.4e-126 413.8 In-house 1-202 (202) alignment 
Range on Protein: 2-203
Range on HMM: 1-202/202.0
KPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGI
|||||||||||||||||.||.|..||.|.||.|||||....|||.|||||||.||||.|.||.|||||.|..|.||.|||||||||||..|||||||.|.
kppssiqtsefdssdeeqievekspiqidwldlsrvniaeklglsalpgckfddvrrsvekdieelksqgvedvfvlctrgelskyrvrrlldlyqqagl

ITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLS
|.||.|||||..||||||..|.|||...||.|||||.|||||||||.||.|||||||.|||.|..|||.||||.||.||||.||||||.||||||...||
ivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdkleeyls

SR
||
sr
0043147 (Phosphotyrosine protein) phosphatases II 23-198 8.2e-28 92.7 In-house 4-162 (172) alignment 
Range on Protein: 23-198
Range on HMM: 4-162/172.0
EQTPIHISWLSLSRVNCSQFLGLCAlpgckfkdVRRNVQKDTEELKSCGIQDIFVFCTRgelskyrvPNLLDLYQQCGIITHHHPIADGGTPDIASCCEI
  . |. |.|.|... .. . ..           |... .. . ||. ||. |.  ...         .. .|... ||  ...|. |.|.|...   |.
gsdyinasyldlyyipdrfiatqgp........lrntladfwrmlkelgithivnltel........lydpellerlgiqylylpwpDhgvpllelllef

MEELTT--CLKNYRKTLIHCYGGLGRSCLVAACLLLYlsDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFRDKLAA
.| . .  .|..  ..|.||..|.||.....|..|..    .|.|.|.. .|. | .||.|.  ||..|..| ..|  
lefidellalspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.pgavqnpsqyrflyyfekllll
0042113 (Phosphotyrosine protein) phosphatases II 23-192 1.1e-27 92.4 In-house 36-238 (245) alignment 
Range on Protein: 23-192
Range on HMM: 36-238/245.0
EQTPIHISWLSLSRVNCSQFLGLCALPGckfkdvrrNVQKDTEELKSCGIQDIFVFCTRGELSK-----------------------------------Y
  ..|. |. ...|..   ... . ||.        .|..  . |.. ||. |. ...  ||..                                   .
dsdyinasyvdgyritpkfiatqgPlpe........tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtl

RVPNLLDLYQQCGIITHHHPIADGGTPD-IASCCEIMEELTTCLK--NYRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRgSGAI
.| || | ... .|  |..|. |.|.|| ... ....|.. ..|.  .  ..|.|| .|.||.....|..|..       ..|.|.|.. ||. | .||.
evtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.pgav

QTIKQYNYLHEF
||  || .|.|.
qtpsqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 24-193 7.1e-22 74.0 In-house 90-276 (314) alignment 
Range on Protein: 24-193
Range on HMM: 90-276/314.0
QTPIHISWLSL----------------SRVNCSQFLG---------------------LCALPGCKfkdvRRNVQKDTEELKscgiqdifvfctrgelsk
|.|  | . ..                .  |.    .                     |. |.|         . .| |.||                  
qgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk..................

yRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTClKNYRKTLIHCYGGLGRSC--LVAACLLLYLsDTiSPEQAIDSLRDLRG----SGAI
 .. .  .|... ||  ...|. ||..|...   |..| . .. .. ...|.|| .| ||..  .|||.|...| .  |.|.|.. .|  |      |.|
.eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll.gv.sleealedvrlkRpinpnpgfi

QTIKQYNYLHEFR
.. .|| . .|..
eqleqyefileal
0046846 (Phosphotyrosine protein) phosphatases II 27-196 3.7e-45 149.1 In-house 3-172 (176) alignment 
Range on Protein: 27-196
Range on HMM: 3-172/176.0
IHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEEL
.....| |. . . . | |...|.... ...|..... |.||. ||. .. .... ||.....||. ..... ||  .|.|. |.|.||.. ..|..|..
lrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefi

TTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKL
 ..||. ...|.||..|.||.....|..||.|.  .|.|.|.. .|. |  ||.|| .|| .|.||  .|
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0036282 (Phosphotyrosine protein) phosphatases II 27-196 4.5e-29 96.8 In-house 5-169 (174) alignment 
Range on Protein: 27-196
Range on HMM: 5-169/174.0
IHISWLSLSRVNCSQFLGLCALPgckfkdvrrnvqkDTEELKSCGIQDIFVFCTRGELSKYRVPNLL----DLYQQCGIITHHHPIADGGTPDIASCCEI
|. |.|.||...   ..| . |.             . |.||. ||.... ...  || .|...|.     . . . ||  .. |. |.|.||..  .|.
inaspldlsyitprliagqgpla.............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillef

MEELTTCLKN--YRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLR--GSGAIQTIKQYNYLHEFRDKL
.... ..|..   ...|.|| .|.||. ...|..|..     |...|.| .| ||   .|..||  || .|..|...|
vkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0044763 (Phosphotyrosine protein) phosphatases II 32-196 7e-25 83.1 In-house 21-170 (178) alignment 
Range on Protein: 32-196
Range on HMM: 21-170/178.0
LSLSRVNcsQFLGLCALPGckfkdvrrnvQKDTEELKSCGIQDIFVFCTRGElsKYRVPNLLDLYQQCGIITHHHPIADGGTPD-IASCCEIMEELTTCL
. .|..    .| |..||           ..| | ||  ||. |  ...  |   ......   ... ||  .| || |.|.|| .. . |..| . ..|
inaseil..pglylgslpp..........addlellkelgithivnlteele..lgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal

-KNYRKTLIHCYGGLGRSCLVAACLLLYLSdTISPEQAIDSLRDLRGsgAIQTIKQYNYLHEFRDKL
 .. ...|.||. |.|||....|. |..    .|.|.||. .|  |   ....  |...|.||  .|
dekggpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerRp..ivpnpgqlrqLyefelrl
0037934 (Phosphotyrosine protein) phosphatases II 35-192 2.3e-27 91.6 In-house 38-237 (243) alignment 
Range on Protein: 35-192
Range on HMM: 38-237/243.0
SRVNCSQFLGLCALPGCKfkdvrrNVQK----DTEELKSCGIQDIFVFCTRGELSKYRVPNL----------------------------------LDLY
. ...   | .. .|  .      .|.     . . |.. ||. |  ...  ||... .. .                                  || .
nliyvtprliatqgPlpe......tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

QQCGIITHHHPIADGGTPD-IASCCEIMEELTT---------CLKNYRKTLIHCYGGLGRSCLVAACLLLYLS-DtISPEQAIDSLRDLRGSGAIQTIKQ
.. .|  |..|. |.|.|| .... ....|...         .|.. ...|.||..|.||. ...|..|..|  . ...|.|.. ||. |.  |.||  |
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpgkavqtpsq

YNYLHEF
| .|.|.
yrflyea
PTEN_1 37-197 5.7e-31 102.8 In-house 32-193 (196) alignment 
Range on Protein: 37-197
Range on HMM: 32-193/196.0
VNCSQFLGLC-ALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELskYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLK---N
. .   ..|.  ... .... .. |..| ..||. ||  .. .. . ||  ....  |..... |.. .| || | |.|.... ..| ...  .|.   |
mgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn

YRKTLIHCYGGLGRSCLVAACLLLYLSDtISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLA
 .. |.|| .||||| .|.|..|.|.    ....|.. .|. |  ||... .|  .|..|.. ||
gnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaella
0045098 (Phosphotyrosine protein) phosphatases II 37-196 3.1e-24 81.3 In-house 23-271 (278) alignment 
Range on Protein: 37-196
Range on HMM: 23-271/278.0
VNCSQFLGLCALPGCKFKDVRRN-------------------------------VQKDTEELKSCGIQDIFVFCTRGELS--------------------
  .. .| |. |. ...||.  .                               |... . |.. ||. |   ..  ||.                    
seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

---------------KYRVPNL---LDLYQQCGIITHHH-PIADGGTPDIA---SCCEIMEELTTCLK--------------NYRKTLIHCYGGLGRSCL
               ...| ||      ... |.  .|  |. |.|.|.     |  |..|..  .||              .  ..|.||. |.||.. 
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGt

VAACLLLYLS--DTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKL
..|. |..    .......|.. ||  |.  |.|.  ||..|.||  .|
lvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0041856 (Phosphotyrosine protein) phosphatases II 58-192 1.9e-22 75.1 In-house 45-166 (182) alignment 
Range on Protein: 58-192
Range on HMM: 45-166/182.0
RNVQKDTEELKSCGIQDIFVFCtrgelskyRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTclkNYRKTLIHCYGGLGRSCLVAACLLLY
..| .. . ||. ||. |   .         ..   .|... ||  ...|. |.|.||. ......||      . ...|.|| .|.||.. ..|. |..
stvadflrmlkelgittivnlt........eelywpellerlgiqylylpwpDhgvpdldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmk

LSDtISPEQAIDSLRDLRgSGAIQTIKQYNYLHEF
  . .|.|.|.. .|  | .|...|  || .|. .
klg.vsleeavklvrsrR.pgmvitpnqyfflqla
0049260 (Phosphotyrosine protein) phosphatases II 59-195 9e-25 82.6 In-house 21-148 (152) alignment 
Range on Protein: 59-195
Range on HMM: 21-148/152.0
NVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLdlyqqcgiITHHHPIADGGTPDIASCCEIMEELTTC--LKNYRKTLIHCYGGLGRSCLVAACLLL
.. .. . ||. ||. | . ... || |. ....           .|.|. |.|.||.. . ... ..  .  |..  ..|.||..|.||. ...|..|.
tladfwrmlkelgittivmltellelgklkceqyi........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

YlsDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFRDK
.    .|.|.|.. .|  | .||...  |. .|.|| ..
l..lgvsleeavalvrekR.pgavpnpgqlrflyefekl
0040439 (Phosphotyrosine protein) phosphatases II 59-192 7.6e-19 63.8 In-house 66-241 (249) alignment 
Range on Protein: 59-192
Range on HMM: 66-241/249.0
NVQKDTEELKSCGIQDIFVFCTRGELSKYRVP-----------------------------------NLLDLYQQCGIITHHHPIADGGTP-DIASCCEI
 | .. . |.  ||. |  ...  || .                                       || |         ..... | |.| ........
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

MEELTTCLK---NYRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEF
.|.. ..|.   .  ..|.|| .|.||.....|..|..       ....|.|.. ||. | .||.|.  || .|.|.
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR.pgavqnpeqyrflyea
0048179 (Phosphotyrosine protein) phosphatases II 60-195 3.2e-24 80.7 In-house 18-143 (144) alignment 
Range on Protein: 60-195
Range on HMM: 18-143/144.0
VQKDTEELKSCGIQDIFVFCTRGELSKYRVPnlldlyqqcGIITHHHPIADGGTPDI-ASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYL
. .| |.||. ||  .. ...  |   . ..         ||  .| |. | |.||. . ..|..| . ..|.. ...|.||..|.||.....|. |...
taldlellkklgittvinlteeyepeflere.........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkk

SDtISPEQAIDSLRDLRGsGAIQTIKQYNYLHEFRDK
 . .|.|.|.. .|  |  ||...  |...|.|....
lg.lsleealalvrsrrp.gavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 60-195 2.3e-23 77.9 In-house 18-141 (145) alignment 
Range on Protein: 60-195
Range on HMM: 18-141/145.0
VQKDTEELKSCGIQDIFVFctrgelskyrvPNLLDLYQQCGIITHHHPIADGGTPDI-ASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYL
. .| |.||. ||  .. .            . |.|. . ||  .. |. | |.||. .  .|..| . ..||. ...|.||. |.||.....|. |..|
taldlellkdlgittvlnl...........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll

SDtISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFRDK
 . .|.|.|.. .|  | .||...  |...|.||  .
lg.vsleealelvrsqr.pgavpnpgqlrflyefele
0051082 (Phosphotyrosine protein) phosphatases II 60-191 6.9e-20 66.6 In-house 22-147 (151) alignment 
Range on Protein: 60-191
Range on HMM: 22-147/151.0
VQKDTEELKSCGIQDIFVFCTRGELSkyrvpNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKN--YRKTLIHCYGGLGRSCLVAACLLLY
 . . |.||. ||. |. ...  |       .. ..... ||  .| || |  .|..  . ... |.   | .    ..|.|| .|.||. ...|..|..
ladflellkelgiktivnlrseeerg.....ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml

LSdtISPEQAIDSLRDLRGsGAIQTIKQYNYLHE
|   .|.|.|.. .|  |. |..|.  |. ... 
lg..vsleealeeyrlkrp.gvvqpnqqflfqlf
0051429 (Phosphotyrosine protein) phosphatases II 61-202 6.6e-20 67.3 In-house 35-230 (272) alignment 
Range on Protein: 61-202
Range on HMM: 35-230/272.0
QKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLdlyqqCGIITHHHPIADGGTPDIA-------------------------------------------
..| . ||. ||  |. ...  |. .. .. ..      ||  .|.|| | ..|.|                                            
aadfwrlkelgiktivdLrseeErgrlkcdryw.....pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytd

---------SCCEIMEELTTclknYRKTLIHCYGGLGRSCLVAACLLLYlsDTIS--------------PEQAIDSLRDLRgSGAIQTIKQYNYLHEFRD
         ...|..|.| .     .. |.||..| .|. .|.|.|||.    .|              .|.|.. ||. |  ||.||  || .|.|.  
wpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeaveelraqr.pgavqteeqylflyeall

KLAAHLSS
.|.  | |
ellrslls
subfamily_PRL_pd Subfamily PRL 61-195 1.6e-09 32.0 In-house 24-148 (151) alignment 
Range on Protein: 61-195
Range on HMM: 24-148/151.0
QKDTEELKSCGIQDIFVFCTrgelSKYRVPNLldlyQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKT--LIHCYGGLGRSCLVAACLLlyL
.| .||||  ... .   |      .| . .|    .. ||  .  . .||..|  .   | .| | .  |.  |.   .||  ||||. .. |  |  .
ekfieelkkeevktvvrvce....ptydtekl....ekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalal..i

SDTISPEQAIDSLRDLRgSGAIQtIKQYNYLHEFRDK
 . ...|.|.. .|. |  |||   || ..|.... |
eaGmkyedavefirekr.rgain.skqlkflekykak
0038934 (Phosphotyrosine protein) phosphatases II 64-196 4.8e-17 57.7 In-house 35-176 (194) alignment 
Range on Protein: 64-196
Range on HMM: 35-176/194.0
TEELKSCGIQDIFVFCTRGELSKYRVPNLL--------DLYQQCGIITHHHPIAD-GGTPDIASCCEIMEELTTCLKNY--RKTLIHCYGGLGRSCLVAA
.|||.  .. |.. ...      . | .|         ..... ||  .. |. | | .|...  ..... . . |..    . ..||..||||. ...|
ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

CLLLYLSDTiSPEQAIDSLRDLRgSGAIQTIKQYNYLHEFRDKL
. |.|  .  |.|.||. .|. |  |||........|... . |
aYLiyrlgm.saeeAialfrekR.pgaipnqdyleallkrykel
0039614 (Phosphotyrosine protein) phosphatases II 65-193 1.8e-22 75.6 In-house 119-285 (297) alignment 
Range on Protein: 65-193
Range on HMM: 119-285/297.0
EELKSCGIQDIFVFCTRGELSKYRVP--------------NLLDLYQQCGII-----------------THHHPIADGGTP-DIASCCEIMEELTTCLK-
. ..  |.. |   ..  ||... ..              .||. ..  |..                  ..... |.|.| ......|..|.. ..|. 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--NYRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFR
  . ...|.|| .|.||.. ..|..|..       ......|.. ||  | .||.||  || .|... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.pgavqtpsqyrflydal
0045450 (Phosphotyrosine protein) phosphatases II 65-192 1.5e-20 69.6 In-house 125-299 (307) alignment 
Range on Protein: 65-192
Range on HMM: 125-299/307.0
EELKSCGIQDIFVFCTRGEL---------------------------------SKYRVPNLLDL-YQQCGIITHHHPI---ADGGTP-DIASCCEIMEEL
. |.  |.. |   ..  ||                                  ..|. .. || . . ... .|..     |.|.| .........||.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

TTCLK---NYRKTLIHCYGGLGRSCLVAACLLLYLSDT-------ISPEQAIDSLRDLRgSGAIQTIKQYNYLHEF
 ..|.   .  ..|.|| .|.||.. ..|..|..           .....|.. ||. | .||.|.  || .|.|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.pgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 66-192 1.6e-21 72.5 In-house 107-272 (278) alignment 
Range on Protein: 66-192
Range on HMM: 107-272/278.0
ELKSCGIQDIFVFCTRGELSK----------------------------------YRVPNLLDLYQQCGIITHHHPIADGGTP-DIASCCEIMEELTTCL
 ..  |.. | . ..  ||..                                   .| || | . . . . |.... |.|.| .... ....... ..|
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

K-NYRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEF
. .  ..|.|| .|.||.....|..||.       ....|.|.. ||  |  ||.||  || .|.|.
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.pgavqtpsqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 69-192 4.9e-19 64.2 In-house 108-271 (317) alignment 
Range on Protein: 69-192
Range on HMM: 108-271/317.0
SCGIQDIFVFCTRGELSKYRVP----------------NLLDLYQQCGIITHHHPI-------------------ADGGTP-DIASCCEIMEELTTCLKN
  |.. |  ...  ||..                    .||. ..  ||. .. ..                    |.|.| .. .. ...|.. ..|..
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

-YRKTLIHCYGGLGRSCLVAACLLL-----YLSdTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEF
   ..|.|| .|.||.. ..|..|.     .   ....|.|.. ||  | .||.||  || .|...
pggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.pgavqtpeqyrflyda
subfamily_DSP23_pd Subfamily DSP23 69-192 8.9e-07 23.7 In-house 29-141 (148) alignment 
Range on Protein: 69-192
Range on HMM: 29-141/148.0
SCGIQDIFVFCTRGELSKYRVPNLLdlYQQCGIITHHHPIADggtpDIASCCEIMEELTTclKNyRKTLIHCYGGLGRSCLVAACLLLYLsDTISPEQAI
  |.. .  . ..|.     .|||   ... .|  .| |  .    ..    ...||     ||     .||  | ||.  . || |.     ..  .||
dlgvrylvslteegrphveatpnlt..lvrlriddyhppale....qvvefvrvveeaee..kn.eavsvhcllgrgrtgtmlacylvke.rklaaaeai

DSLRDLRgSGAIQTIKQYNYLHEF
  .| ||  |...|..| . ....
aevrrlr.pgsvetveqeklvrdy
subfamily_PTEN_pd Subfamily PTEN 72-177 1.3e-07 26.8 In-house 47-158 (184) alignment 
Range on Protein: 72-177
Range on HMM: 47-158/184.0
IQDIFVFCTRGELSKYRVPNL--LDLYQQCG--IITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKT--LIHCYGGLGRSCLVAACLLLYLSDTISPE
..|.. | ..    .|.. ||     |..       .. |. |  .| .    ||.|.... |.. .|    .||  | ||. .. ...||.   . ..|
ledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae

QAIDSLRDLRGS
.|..     | .
ealelfaeaRtk
subfamily_PTPMT1_pd Subfamily PTPMT1 88-197 1.7e-10 35.6 In-house 61-169 (171) alignment 
Range on Protein: 88-197
Range on HMM: 61-169/171.0
RVPNLLDLYQQCGIITHHHPIADGG-TPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRGSGAIQTiKQY
.. |  . ... |.   . .. |   .||...  . .| ..   .. ..  .|| .| |||  ..|| |.. .. .|||.|.. |.. |    ... ||.
alansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmk.keklspeeAlkalkkkRkiirlak.kqw

NYLHEFRDKLA
. |.|...|| 
kalqeyeekll
subfamily_PTPDC1_pd Subfamily PTPDC1 93-197 2e-15 51.7 In-house 75-176 (182) alignment 
Range on Protein: 93-197
Range on HMM: 75-176/182.0
LDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYrKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEF
|. ... ||. .  ...| |.. . .  .|.  .. .|..  |. .||. ||||  .. || |.| .. ...|.||. .|. | . .||| .| . ..||
lealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvy.akrltaekaiklvrskr.pksiqtreqvelvkef

RDKLA
.  |.
alfli
0051299 (Phosphotyrosine protein) phosphatases II 100-191 1.4e-13 46.4 In-house 184-280 (288) alignment 
Range on Protein: 100-191
Range on HMM: 184-280/288.0
GIITHHHPIADGGTPD-IASCCEIMEELTTCLKN-YRKTLIHCYGGLGRSCLVAACLLL----YLSDTISPEQAIDSLRDLRGSgAIQTIKQYNYLHE
 .. |.. . | |.|| . .. ...... ..|..    ...||  |.||.. ..|..||        ......|.  ||  |   ..||  || ...|
vthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg.mvqtpeqyrfvye
0047943 (Phosphotyrosine protein) phosphatases II 101-191 5.7e-17 57.5 In-house 169-266 (273) alignment 
Range on Protein: 101-191
Range on HMM: 169-266/273.0
IITHHHPIADGGTP-DIASCCEIMEELTTCLK---NYRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHE
.. |.... | |.| ...|. |..|.. ..|.   .  ....|| .|.||.. ..|..||.       ......|.  ||. |  |..||  || .|.|
thfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqR.pgmvqtpeqyrflye
0036941 (Phosphotyrosine protein) phosphatases II 101-193 2e-16 55.6 In-house 171-273 (297) alignment 
Range on Protein: 101-193
Range on HMM: 171-273/297.0
IITHHHPIADGGTPD-IASCCEIMEELTTCLK---NYRKTLIHCYGGLGRSCLVAACLLL----Y---LSDTISPEQAIDSLRDLRGSgAIQTIKQYNYL
 . |.. . | |.|. .||. ...|.. ..||   .  ..|.|| .|.|||. ..|. |.           .... .|. .||. |   |.||  || .|
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.avqtleqyrfl

HEFR
.|. 
yeal
0046845 (Phosphotyrosine protein) phosphatases II 101-192 1.2e-15 53.2 In-house 168-269 (284) alignment 
Range on Protein: 101-192
Range on HMM: 168-269/284.0
IITHHHPIADGGTP-DIASCCEIMEELTTCLKN---YRKTLIHCYGGLGRSCLVAACLLLYLS----D---TISPEQAIDSLRDLRgSGAIQTIKQYNYL
.. |.... | |.| ....  |..... ..|.|     ....|| .|.||.. ..|. ||.      .   ......|.  ||. |  |..||  || ..
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR.pgmvqtleqyrfv

HEF
.|.
yea
Y_phosphatase Protein-tyrosine phosphatase 101-191 2.7e-08 28.9 Pfam-A 136-231 (235) alignment 
Range on Protein: 101-191
Range on HMM: 136-231/235.0
IITHHHPIADGGTP-DIASCCEIMEELTTCL-KNYRKTLIHCYGGLGRSCL-VAACLLLYLSD---TISPEQAIDSLRDLRgSGAIQTIKQYNYLHE
   |..   | |.| .  |  ...... .   ..  ....||  | ||..  ||. .||   .   ...  |.. .||  |  |..|...|| .|..
kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR.pgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 101-191 2.7e-08 28.9 In-house 136-231 (235) alignment 
Range on Protein: 101-191
Range on HMM: 136-231/235.0
IITHHHPIADGGTP-DIASCCEIMEELTTCL-KNYRKTLIHCYGGLGRSCL-VAACLLLYLSD---TISPEQAIDSLRDLRgSGAIQTIKQYNYLHE
   |..   | |.| .  |  ...... .   ..  ....||  | ||..  ||. .||   .   ...  |.. .||  |  |..|...|| .|..
kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR.pgmvqsleqYiflyk
0050432 (Phosphotyrosine protein) phosphatases II 102-192 1.4e-14 49.6 In-house 199-294 (308) alignment 
Range on Protein: 102-192
Range on HMM: 199-294/308.0
I--THHHPIADGGTPD-IASCCEIMEELTTCLKNyRKTLIHCYGGLGRSCLVAACLLL----YLSDTISPEQAIDSLRDLRGSgAIQTIKQYNYLHEF
.   |..   |.|.|. .... ...|.. ..|..  ....||  |.||.. ..|..||        ......|.  ||  |   ..||  || .|.. 
vthfhytnWpdhgvPpspeilldflelvrkslpg.gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg.mvqtpeqylflyra
0048567 (Phosphotyrosine protein) phosphatases II 102-177 2.1e-06 22.2 In-house 39-120 (157) alignment 
Range on Protein: 102-177
Range on HMM: 39-120/157.0
ITHHHPIADGGTPDIASCCEIMEELTTCLK----NYRKTLIHCYGGL---GRSCLVAACLLLYLSDtISPEQAIDSLRDLRGS
. ......| | ...| . . .  |   ||    . ..  .||. ||   ||. ....| |..  . ..||.||. ||  | .
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlg.ftpeeaiaplrivrpg
PTPc_DSPc_SM00012 104-191 2.8e-09 32.5 In-house 6-101 (105) alignment 
Range on Protein: 104-191
Range on HMM: 6-101/105.0
HHHPIADGGTPD-IASCCEIMEELTTCLKNY---RKTLIHCYGGLGRSCLVAACLLLYLS-----DTISPEQAIDSLRDLRgSGAIQTIKQYNYLHE
|.. . | |.|.   | .|..... .. ..      ...||  | ||.. ..|  .|. .     .... .| . .||. | .|..||  || .|..
hytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR.pgmvqteeqylflyr
DSPc_SM00195 109-192 2.9e-06 22.2 In-house 169-257 (263) alignment 
Range on Protein: 109-192
Range on HMM: 169-257/263.0
ADGGTP-DIASCCEIMEELTTCLKN-YRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRGSgAIQTIKQYNYLHEF
 | |.| .  |. |........ ..    ...||  |.||.. ...  ...      .... .. . .||. | . ..|| .|| ...| 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfiyea
PTPc_SM00194 109-192 2.9e-06 22.2 In-house 169-257 (263) alignment 
Range on Protein: 109-192
Range on HMM: 169-257/263.0
ADGGTP-DIASCCEIMEELTTCLKN-YRKTLIHCYGGLGRSCLVAACLLLY----LSDTISPEQAIDSLRDLRGSgAIQTIKQYNYLHEF
 | |.| .  |. |........ ..    ...||  |.||.. ...  ...      .... .. . .||. | . ..|| .|| ...| 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfiyea
PTPc_motif_SM00404 117-194 2.9e-07 25.5 In-house 64-139 (140) alignment 
Range on Protein: 117-194
Range on HMM: 64-139/140.0
ASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFRD
.   .... . .. |. .| |.||. |. ||  .... |.. .. .| ..|.. ... | .   ....  . |.|...
kyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr.yrqlslaeayefvkerR.piispnlnfvrqLieyek
DSPc Dual specificity phosphatase, catalytic domain 122-193 2.6e-07 25.6 Pfam-A 62-131 (133) alignment 
Range on Protein: 122-193
Range on HMM: 62-131/133.0
IMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFR
..| . .. .. .| |.||. |. ||  .... |.. .. .| ..|.. ... | |   .....   | |..
avefiekaeqkgkkvlVHCqaGisRSatliiaYlmk.tknlslneAyefvkerr.skispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 122-193 2.6e-07 25.6 In-house 62-131 (133) alignment 
Range on Protein: 122-193
Range on HMM: 62-131/133.0
IMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFR
..| . .. .. .| |.||. |. ||  .... |.. .. .| ..|.. ... | |   .....   | |..
avefiekaeqkgkkvlVHCqaGisRSatliiaYlmk.tknlslneAyefvkerr.skispnagflrqLleye