Gene DUSP10 in Homo sapiens

Synonym: MKP-5, MKP5, DUSP10

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP10
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP013_AA protein Get Run
HsapP013_AA_319-466 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 165-278 1.8e-13 43.0 Pfam-A 7-112 (113) alignment 
Range on Protein: 165-278
Range on HMM: 7-112/113.0
SHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKiSRRRLQQGKITVLDLISCREG-KDSFKrifskEIIVYDeNTNEPSRVMPSQPLHIVLESLKREg
..| ....|..|.|.. ||.|.||.|||...  .    || .  |    . .. ..   |. |     ...||. .. . |. . . .|   |..|  . 
ellekekvvllDvRspeeyakghIpgAvnvpldsl.yprrdlffkdklaeeleesgkkldkdk.....tvvvyc.rsgnrsggaaalllalilkelgyk.

kEPLVLKGGLSSFKQ
 .  ||.||....|.
.nvyvLdGGfeawka
Subfamily.CDC25.PD 172-209 3.5e-06 18.4 In-house 15-52 (117) alignment 
Range on Protein: 172-209
Range on HMM: 15-52/117.0
PVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGK
 .|||||   ||.  ||.|||..   ...... |.. |
yiiiDcRypyeyegGHikgavnlysreeleeeflkepk
Family.CDC25.PD 172-209 3.5e-06 18.4 In-house 15-52 (117) alignment 
Range on Protein: 172-209
Range on HMM: 15-52/117.0
PVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGK
 .|||||   ||.  ||.|||..   ...... |.. |
yiiiDcRypyeyegGHikgavnlysreeleeeflkepk
Group.Cx5R-II.PD 172-209 3.5e-06 18.4 In-house 15-52 (117) alignment 
Range on Protein: 172-209
Range on HMM: 15-52/117.0
PVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGK
 .|||||   ||.  ||.|||..   ...... |.. |
yiiiDcRypyeyegGHikgavnlysreeleeeflkepk
subfamily_CDC25_pd Subfamily CDC25 173-208 6.1e-06 17.4 In-house 14-49 (114) alignment 
Range on Protein: 173-208
Range on HMM: 14-49/114.0
VIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQG
.|||||   ||.  ||.||| .   ...... |.. 
liiDcRypyEyegGHikgavnlysreeveeellkkp
0044763 (Phosphotyrosine protein) phosphatases II 310-463 1.3e-43 144.0 In-house 11-171 (178) alignment 
Range on Protein: 310-463
Range on HMM: 11-171/178.0
PIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHL-------PLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAH-QCG
... .. ...  .. |||.|.||.  .|.||. ...|.|....|.|. |       . |..|.  ..|...|  |.. ..|...|.|..||||||. ..|
nleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg

KGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPiISPNLNFMGQLLEFEEDLN
.  |.||.|||.||.|.|.|||||. .... .|...|. .|| |.|| ... ||.|||. |.
gpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP10_pd Subfamily DSP10 311-467 2.6e-78 255.4 In-house 3-158 (159) alignment 
Range on Protein: 311-467
Range on HMM: 3-158/159.0
IPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEkGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQA
.||..|||.|.....|||||||.|.||.|||...|||| .|.||||..| ...|   ..|||.|..|..||||.||||||.||||||...|. .|.||||
spteadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqa

GVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVT
|.|||||.||||||||......||||||| |||||||||||||||||||..||.  .
GisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska
0046846 (Phosphotyrosine protein) phosphatases II 315-462 1.2e-30 102.0 In-house 5-172 (176) alignment 
Range on Protein: 315-462
Range on HMM: 5-172/176.0
PDIENAELTPILPFLFLGNEQ----------DAQDLDTMQRLNIGYVINVTTHLPLYH---------YEKGLFNYKRLPATDSNKQNLrQYFEEAFEFIE
.....  |. |.. |.||.             |..|. ...|.|..|.|.|..  | .         .||  . |..||  | .  .| ....|..|||.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

EAHQCGKGLLIHCQAGVSRSATIVIAYLMKH-TRMTMTDAYKFVKGKRP-IISPNLNFMGQLLEFEEDL
|| . |.  |.||.||..|..|.|.|||...   ... .|...|. .||  . .. ... .| |||  |
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0037934 (Phosphotyrosine protein) phosphatases II 315-460 2.2e-30 101.4 In-house 32-239 (243) alignment 
Range on Protein: 315-460
Range on HMM: 32-239/243.0
PDIENAELTPILPFLFLGNE--------QDAQDLDTMQRLNIGYVINVTTHL-------------------------------------------PLYHY
 |  || |....| |....          .|.... ...|.|......|.                                             .|...
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

EKGLFNYKRLPATD----SNKQNLRQYFEEAFEFIEE-----AHQCGKGLLIHCQAGVSRSATIVIAYLMKHT-RMTMTDAYKFVKGKRPI-ISPNLNFM
..  ..| .||  |    .. ..| ....|. |||||     |   |. .|.|| |||.|..|...||||..  .... .|.|... .||  . ......
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

GQLLEFEE
 .| |.. 
rflyeall
subfamily_DSP6_pd Subfamily DSP6 318-463 5e-55 179.3 In-house 10-155 (158) alignment 
Range on Protein: 318-463
Range on HMM: 10-155/158.0
ENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSAT
|.. .  |||.|.||...||..|.....|.| ||.|||..||  . |.| ..|...|..|  .||| ..| ||.|||.||..  ...|.|| ||.||| |
eaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

IVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
...|||||.. ... |||..|| ... ||||.|||||||.||. |.
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_DSP8_pd Subfamily DSP8 318-464 2.6e-45 147.8 In-house 11-156 (159) alignment 
Range on Protein: 318-464
Range on HMM: 11-156/159.0
ENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFnYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSAT
.. ..| ||..|.|| ..|. . .....|.|.||.|. .. |  .  |    . |.|  |... .| ..|....|||. |..  .  |.|. || |||||
advgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsat

IVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNN
..|||.||. .|.. .||.||| ||| |||||||.|||||.|..|..
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_DSP19_pd Subfamily DSP19 319-462 2.1e-40 132.5 In-house 9-150 (152) alignment 
Range on Protein: 319-462
Range on HMM: 9-150/152.0
NAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKglFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATI
. |.. . | |.||  . |.| ..... .| ...||.|..|  . ..  |.|. ..  | ....| .|..||..|||||..    .|.||.|||||||..
dlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd..ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

VIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL
|||||||........|.. |. .|| |.||  |. || |.|. |
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP14_pd Subfamily DSP14 320-468 5.3e-41 134.2 In-house 5-150 (157) alignment 
Range on Protein: 320-468
Range on HMM: 5-150/157.0
AELTPILPFLFLGnEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKglFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIV
|.|. | | |||.  . |.. ..... .|  .||||..||  ....  ... ..|..|.....| ..|.|. . |||... |   |.|| |||||||...
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkd..iervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

IAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTP
.|||||. .... .||| || .||||.||. |  || ..|. |.. .. 
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssv
0041856 (Phosphotyrosine protein) phosphatases II 320-467 7.8e-36 118.7 In-house 17-177 (182) alignment 
Range on Protein: 320-467
Range on HMM: 17-177/182.0
AELTPILPFLFLGNEQD--------------AQDLDTMQRLNIGYVINVTthLPLYHYE---KGLFNYKRLPATDSNKQNlrqyFEEAFEFIEEAHQCGK
  |. |.. |.||.  .              |..|.....|.|....|.|   .|| .|   .  ..|..||  | .  .    ..|...||||... |.
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleegg

GLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRP--IISPNLNFMGQLLEFEEDLNNGVT
  |.|| |||.|..|.|.|||||. ......|.|.|. .||  .|.|| .|. ||...|. |..  .
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_STYX_pd Subfamily STYX 320-460 4.1e-22 72.0 In-house 10-155 (166) alignment 
Range on Protein: 320-460
Range on HMM: 10-155/166.0
AELTPILPFLFLGNEQDAQ--DLDTMQRLNIGYVINVTTHLPLY---HYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSR
 |.  ||| ||||    |.   |.....  | ... .   .         .  | |  |  .|.  .|. .|. .  |||... | |  .|.| .||.||
remqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisr

SATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
||..||||.|.   .   .|...|. .|  |.||  |. || |.| 
saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_Slingshot_pd Subfamily Slingshot 322-461 1.4e-38 126.0 In-house 19-156 (169) alignment 
Range on Protein: 322-461
Range on HMM: 19-156/169.0
LTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHyeKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIA
 . |  ...|| | .| .|. ... .. |..|||  .  ..  .. |.|...   |.....| .|..|...|||.|.. |  .|.||. ||||||..|||
askifdhvylGsewnasnleelkengveyilnvtkeidnff..pekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEED
| ||. .... .|...|| .| .| || .|. || |.|  
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
0049772 (Phosphotyrosine protein) phosphatases II 322-462 3.8e-34 114.2 In-house 155-273 (314) alignment 
Range on Protein: 322-462
Range on HMM: 155-273/314.0
LtpilpflflgNEQDAQDLDTMQrlnigyvinvTTHLPLYHYEKGLFNYKRLPATDsNKQNLRQYFEEAFEFIEEAhQCGKGLLIHCQAGVSRSAT-IVI
           || .|.||....          . . .  ..|.  ..|.|.| .| . ..| ..|.|..|||||| . |. .|.||.||..|..| .|.
g..........neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvva

AYLMKHTRMTMTDAYKFVKGKRPiISPNLNFMGQLLEFEEDL
|||||. .... .|...|. ||| |.|| .|. ||...|. |
aylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0045098 (Phosphotyrosine protein) phosphatases II 322-463 7.7e-30 99.6 In-house 22-272 (278) alignment 
Range on Protein: 322-463
Range on HMM: 22-272/278.0
LTPILPFLFLGNEQ-----------------------------------------DAQDLDTMQRLNIGYVINVTTHLPL--------------------
   |.|.|.|||                                            |....... |.| .....|. ..|                    
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

------------------------------YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQ--------------CGKGLLIHCQAGVSRSA
                              . ..   ..|.  |  ..  ... ..| |..|||.||..               |.  |.||.|||.|..
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TIVIAYLMKHT---RMTMTDAYKFVKGKRPI-ISPNLNFMGQLLEFEEDLN
|.|.||||..    .... .|.|... .||. . .||... .| ||. .| 
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0036282 (Phosphotyrosine protein) phosphatases II 322-464 7.7e-29 96.0 In-house 12-171 (174) alignment 
Range on Protein: 322-464
Range on HMM: 12-171/174.0
LTPILPFLFLGNEQDAqDLDTMQRLNIGYVINVTTHLPL-------------YHYEKGLFNYKRLPATDSNKQNLRQyFEEAFEFIEEAHQC--GKGLLI
|. |.| |..|.   | ... ...|.| .|.....  .|             ...|.  ..|..||  | .  .| . ..|...|.|||..   |. .|.
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCQAGVSRSATIVIAYLMKHTRM-TMTDAYKFVKGKR---PIISPNLNFMGQLLEFEEDLNN
|| |||.|..|.|.||||..  . .. ||...|. .|   | . .. ... .| .||  |..
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
0051082 (Phosphotyrosine protein) phosphatases II 322-459 4.4e-25 83.5 In-house 8-150 (151) alignment 
Range on Protein: 322-459
Range on HMM: 8-150/151.0
LTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYhYEKGL-----FNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQC-GKGLLIHCQAGVSRS
.. . ..|....   |..|.....|.| ...|...  . . |.. .     ......| .|   ..| ..|... ||.|.. .. .. .|.|| ||..|.
fsyvtgglyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATIVIAYLMKhTRMTMTDAYKFVKGKRP-IISPNLNFMGQLLEFE
.|.|..|||.  .... .|..... ||| .. ||  |. ||....
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
PTPc_motif_SM00404 323-460 4.9e-44 144.6 In-house 3-139 (140) alignment 
Range on Protein: 323-460
Range on HMM: 3-139/140.0
TPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYhYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAY
. ||| |.||....||... .. |.| .|||||.  .|  .|.  |.....|  |..|..| .|.... .|||.|.. |.  |.|||||||||||..|||
srilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
||.   ... .||.||| .||||||||||. ||.|.|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP12_pd Subfamily DSP12 323-460 3.3e-38 125.5 In-house 3-141 (155) alignment 
Range on Protein: 323-460
Range on HMM: 3-141/155.0
TPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTH-LPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIA
. ||| |.||. ...|. .... |.|  |. |... || .. .||  ..| ....|...... ....||..||||| . .. .|.|||||||||.|||||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
||||.... ...|.|.|| |.| |.|| .|. ||  ||.
YlmkkeklslekAlklvkekkpeiepNegFleQLklfek
PTEN_1 323-465 3.5e-38 126.4 In-house 38-194 (196) alignment 
Range on Protein: 323-465
Range on HMM: 38-194/196.0
TP----ILPFLFLGNEQDA-QDLDTMQRLNIGYVINVTTHLPL-------YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAH--QCGKGLLIHC
.|    | ..|..|.. |. .|||...  .|  |.|..   .|       ....|. ..|...| .| ....|.. |... .||| .   ..|.  |.||
rpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

QAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNG
.||..||.|.|.||||.. ..|. .| ..|. ||| ..||  .. .|||....|...
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0048179 (Phosphotyrosine protein) phosphatases II 323-460 1.1e-37 124.3 In-house 5-142 (144) alignment 
Range on Protein: 323-460
Range on HMM: 5-142/144.0
TPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAY
. ||| |.||.  .|.||.....|.|..|||.|.. . ...|.  ..| .||  | .  .| ....|..||||||.. |.  |.||.|||.|..|.|.||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

LMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
|||. .... .|...|. .||.. || ... .|||.|.
lmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP15_pd Subfamily DSP15 323-461 1.2e-34 113.6 In-house 3-138 (151) alignment 
Range on Protein: 323-461
Range on HMM: 3-138/151.0
TPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTThlplyH----YEKglFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATI
. .|| |.||| .|..| . ... ||  ...|             ..  ..|| ..|.|. ...| ..|.|. ||| ..   ... |.|| ||||||.|.
skvlpglylgnfrdskdeelLkeknithilsvhd.....nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtl

VIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEED
|.||||  | .   || ...| .| .  ||. |  || |.|. 
vvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP3_pd Subfamily DSP3 323-464 2.5e-34 112.3 In-house 12-159 (162) alignment 
Range on Protein: 323-464
Range on HMM: 12-159/162.0
TPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTH------LPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKG-LLIHCQAGVSRS
  . | |..|.|. |.| . ...| | .|.| .            .|..  ..|  |...|. . .|..|||.|..||.|| .  .| .|.||..|||||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

ATIVIAYLMKHTRMTMTDAYKFVKGKRPIiSPNLNFMGQLLEFEEDLNN
||.|.|||| . .||...| . |. || |  ||  |. || |..|.|..
atlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelkr
0049260 (Phosphotyrosine protein) phosphatases II 323-463 1e-33 111.5 In-house 9-150 (152) alignment 
Range on Protein: 323-463
Range on HMM: 9-150/152.0
TPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL-YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEE-AHQCGKGLLIHCQAGVSRSATIVI
.........|..  |.... ...|.|......|..|.| . ... ...|..||  |.. ..| |.......|||. |.. |.  |.|| |||.|..|.|.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYLMKhTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
||||.  .... .|...|. |||.. || ... .|.|||. |.
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekllk
subfamily_DSP1_pd Subfamily DSP1 324-463 2.1e-48 158.5 In-house 20-157 (163) alignment 
Range on Protein: 324-463
Range on HMM: 20-157/163.0
PILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLyHYEKgLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYL
 ||.||.|| |..| .|.....|.|  ..||...|.  ..|. ||.||.|.  ||.|... ..|||. |||.|.....  .|||||||.|||.|...|||
kildfLylGsetvasnleiLkslgitailnvskeldn.vfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
||..|.....|..||| .|.|||||..|..|||..|..| 
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0048076 (Phosphotyrosine protein) phosphatases II 324-462 5.8e-37 121.9 In-house 6-142 (145) alignment 
Range on Protein: 324-462
Range on HMM: 6-142/145.0
PILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHyeKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYL
 ||| |.||.  .|.||.....|.|..|.|.|. |.|.   .  ..| .||  | . ..| ....|..||||||.. |.  |.||.|||.|..|.|.|||
eilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL
|.. .... .|...|. .||.. || ... .|.|||. |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0043147 (Phosphotyrosine protein) phosphatases II 324-462 6.1e-36 119.1 In-house 21-160 (172) alignment 
Range on Protein: 324-462
Range on HMM: 21-160/172.0
PILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTH-LPLYHYEKGLFNYKRLPATDSNKQnLRQYFEEAFEFIEE--AHQCGKGLLIHCQAGVSRSATIVI
 .......... .|.... ...|.|....|.|.. .. ...|.  . | .||  | . . | ....|..|||.|  | . |.  |.|| |||.|..|.|.
rfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva

AYLMKhTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL
||||.  .... .|...|. |||....| ... .|..||. |
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 324-459 8e-25 83.1 In-house 49-239 (245) alignment 
Range on Protein: 324-459
Range on HMM: 49-239/245.0
PILPFLFLGNEQDAQDLD----TMQRLNIGYVINVTTHLP--------------------------------------------LYHYEKGLFNYKRLPA
 | | .....   .....     ...|.| .....|.  .                                             .....  ..| .|| 
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

TDSNKQNLRQYFEEAFEFIEEAHQ--CGKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFE
 | .  .| .......||...| .   .. .|.|| |||.|..|...||||     |. .... .|.|... .|| . ...... .| |..
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_LRR-DSP_pd Subfamily LRR-DSP 325-463 3.6e-33 108.8 In-house 123-259 (263) alignment 
Range on Protein: 325-463
Range on HMM: 123-259/263.0
ILPFLFLGNEQDAQDLDTMQRLNIGYV-INVTTHLPLYHyekGLFNYKRL-PATDSNKQNLRQYFEEAFEFIEEAHQCGkGLLIHCQAGVSRSATIVIAY
|.. ||||  . |..   .. |.. .. . |.   ||.     || |  .  . | .. .. |.|||   ||||  . | |.|.||.||||||.|.||.|
iidklflGgldsannksilkdlgvthillavadfePlfP...klfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisy

LMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
|||. |... .|. .|. ||| | ||  |. ||. .|..| 
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_STYXL1_pd Subfamily STYXL1 325-462 6.2e-27 87.7 In-house 14-153 (157) alignment 
Range on Protein: 325-462
Range on HMM: 14-153/157.0
ILP-FLFLGNEQDAQDLDTMQRLNIGYVINVTTH-LPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAY
.|| .|.|||...||.    . | .  ..||..   .|..  ..  .  ...  |.|. .| . ..|| .|||. .. |. .|.  . |.||||...|||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

LMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL
|| . ..|. .|||..|  .. . || .|. || |.|..|
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 328-460 4e-33 108.0 In-house 14-145 (148) alignment 
Range on Protein: 328-460
Range on HMM: 14-145/148.0
FLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLfNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHT
|||||. . | ||.... |..  ..| |   .    ..|. .|  ..  | .|..|...||.. .|...|.. |.  |.|.| |||||. .....|... 
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgi.eYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

RMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
|... .|. .|| ||. . ||| |. || |.|.
rvslkealalvkskrryvdpnlgfLkqLaeleq
DSPc Dual specificity phosphatase, catalytic domain 329-460 1.7e-43 142.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 329-460
Range on HMM: 1-132/133.0
LFLGNEQDAQdLDTMQRLNIGYVINVTTHLPL-YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHT
|.||....|. |. .. |.| .|||||.. |  . ..|. ..| |.|  |...... ...||| ||||.|.| ||  |.|||||.|||||..||||||  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
......||.||| .|..|||| .|..||||.|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 329-460 1.7e-43 142.7 In-house 1-132 (133) alignment 
Range on Protein: 329-460
Range on HMM: 1-132/133.0
LFLGNEQDAQdLDTMQRLNIGYVINVTTHLPL-YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHT
|.||....|. |. .. |.| .|||||.. |  . ..|. ..| |.|  |...... ...||| ||||.|.| ||  |.|||||.|||||..||||||  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
......||.||| .|..|||| .|..||||.|.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_MKPLT_pd Subfamily MKPLT 329-460 1e-26 87.4 In-house 29-158 (164) alignment 
Range on Protein: 329-460
Range on HMM: 29-158/164.0
LFLGNEQDAQDLDTMQRLNIGYVINVTTHLpLYHYEKgLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTR
|.||| ..|..   .. |.| ...||..   .  . |  ..| ..   |  ...| ...| | .|. .| . |  .|.||. |.|||... .|.|.|  .
lylGnakhatnekvlkdlkithivnvsqek.kdafpk.sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

MTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
 |. .||...| .| |..||  |. || .|||
wtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 329-460 1e-26 87.4 In-house 29-158 (164) alignment 
Range on Protein: 329-460
Range on HMM: 29-158/164.0
LFLGNEQDAQDLDTMQRLNIGYVINVTTHLpLYHYEKgLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTR
|.||| ..|..   .. |.| ...||..   .  . |  ..| ..   |  ...| ...| | .|. .| . |  .|.||. |.|||... .|.|.|  .
lylGnakhatnekvlkdlkithivnvsqek.kdafpk.sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

MTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
 |. .||...| .| |..||  |. || .|||
wtlkeayeylkerrsivapnrGflkqlakfee
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 329-463 3.1e-26 85.6 In-house 10-153 (154) alignment 
Range on Protein: 329-463
Range on HMM: 10-153/154.0
LFLGNEQDAQDLDTMQRLNIGYVINVTTHLP-LYHYE------KGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAH--QCGKGLLIHCQAGVSRSATIV
|...  . | .   .|  ||  ..|| .  . |.  |        ...| .|   |  .... . .. |||||..|       ..|.|...||||||...
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

IAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
|.|||.. ....  |....|  |.||.||  |. ||  || .| 
isylmdklkislslalellkdsryiikPnqGflkqleifekell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 329-463 9.3e-24 77.2 In-house 6-142 (145) alignment 
Range on Protein: 329-463
Range on HMM: 6-142/145.0
LFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLY--HYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKH
|. |    |.|. |.| | |  ..|...   .   .     ..   . | | .  .| |.|.|  .||.  .. | |...|| |||||| |. .|.|||.
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

TRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
  ||...| . |. .|    ||..|. .||..| .| 
cnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0051429 (Phosphotyrosine protein) phosphatases II 329-465 6.1e-21 70.7 In-house 24-227 (272) alignment 
Range on Protein: 329-465
Range on HMM: 24-227/272.0
LFLGNEQ---DAQDLDTMQRLNIGYVINVTTHL-------PLYHyekGLFNYKRLPATDSNKQNLRQYF-------------------------------
|....     .|.|......|.| .......         ..|.     ..| .||  |.  .  ....                               
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------EEAFEFIEEAHQcGKGLLIHCQAGVSRSATIVIAYLMKhTRMT--------------MTDAYKFVKGKRPIISPNLNFMGQLL
                 |.  |..|. .. |. .|.|| ||..|..|.| ..|.   ...              . .|.. .. .|| . ..  .. .|.
evmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

EFEEDLNNG
|.. .| ..
eallellrs
0040439 (Phosphotyrosine protein) phosphatases II 337-461 8.5e-27 89.8 In-house 44-244 (249) alignment 
Range on Protein: 337-461
Range on HMM: 44-244/249.0
A------------------------QDLDTMQRLNIGYVINVTTHLPL-----------------------------------------YHYEKGLFNYK
|                         ... ...|.|......|.  .|                                         ..|..  . ..
AsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvl

RLPATDSNKQNLRQYFEEAFEFIEEAHQ------CGKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
 .. ||   ... ..||....|||....      .|. .|.|| |||.|..|...||||     |. .... .|.|... .|| . .|.... .|.|.. 
hiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

D
.
e
0038934 (Phosphotyrosine protein) phosphatases II 339-466 3.5e-23 77.7 In-house 48-180 (194) alignment 
Range on Protein: 339-466
Range on HMM: 48-180/194.0
DLDTMQRLNIGYVINVTTHLPLYHYEKGL---FNYKRLPATDS----NKQNLRQYFEEAFEFIEEAHqcGKGLLIHCQAGVSRSATIVIAYLMKHTRMTM
.. . .  ..|.||..| . ..|..|.     . | .||  |     . ..|..... . ||..|    |.  ..|| ||..|..|.|.|||... .|..
rylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp..ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsa

TDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGV
 .|..... ||| . || ... .||.. ..|...|
eeAialfrekRpgaipnqdyleallkrykelrkav
0045450 (Phosphotyrosine protein) phosphatases II 342-460 3e-25 85.0 In-house 126-301 (307) alignment 
Range on Protein: 342-460
Range on HMM: 126-301/307.0
TMQRLNIGYVINVTTHLPLY----------------------------HyeKGLFNYKRLPATDS-----------------NKQNLRQYFEEAFEFIEE
 ............|.  .|                             |  .. . . .|. ||.                   ... ..|||...||||
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

AHQ------CGKGLLIHCQAGVSRSATIVIAYLMKHTR--------MTMTDAYKFVKGKRPIISPNLNFMGQLLEFEE
...      .|.  |.|| |||.|..|...||||.. .        ... .|.|... .|| . .|.... .| |.. 
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 342-462 4e-21 71.2 In-house 120-288 (297) alignment 
Range on Protein: 342-462
Range on HMM: 120-288/297.0
TMQRLNIGYVINVTTHLPLYH-----------------------YEKGLF-----------------NYKRLPATDSNKQNLRQYFEEAFEFIEEAHQ--
 ...... .....|.  .| .                       .... .                  .  ..  | .  .. ... |..|...||..  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-CGKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL
  |.  |.|| |||.|..|...||||     |. .... .|.|... .|| . ...... .| ... .|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0040438 (Phosphotyrosine protein) phosphatases II 343-463 4.4e-23 77.5 In-house 106-276 (317) alignment 
Range on Protein: 343-463
Range on HMM: 106-276/317.0
MQRLNIGYVINVTTHLPLY---------------------------HyeKGLFNYKRLPATDS----------------NKQNLRQYFEEAFEFIEEAHQ
............|.  .|                            .  .. ... .|. .|.                  ... ..... ..|.|....
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

C----GKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLN
.    |. .|.|| |||.|..|...||||     |. ......|.|... .|| . ...... .| ... .. 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_RNGTT_pd Subfamily RNGTT 344-444 3.1e-07 24.2 In-house 51-157 (189) alignment 
Range on Protein: 344-444
Range on HMM: 51-157/189.0
QRLNIGYVINVTTHLPLYHYEKG---LFNYKRLPATDSNK----QNLRQYFEEAFEFIEeaHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYK
.. ..|.||..|   . |. |.      .|..|  .   .    .. ... .   ||..  ..  . . .||. |  |.  ....||.... . . .| .
lkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaava

FVKGKRP-I
  .  ||  
lFakaRppG
0043336 (Phosphotyrosine protein) phosphatases II 345-459 1.4e-17 59.5 In-house 110-273 (278) alignment 
Range on Protein: 345-459
Range on HMM: 110-273/278.0
RLNIGYVINVTTHLP-------------------------------------------LYHYEKGLFNYKRLPATDSNKQ-NLRQYFEEAFEFIEEAHQC
 |..  ....|.                                               .....    |  |.  | .   .| ....   ...|  . .
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealeds

GKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFE
.. .|.|| |||.|..|....||.     |. .... .|.|... .|| . ...... .| |..
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_DSP11_pd Subfamily DSP11 346-442 1.3e-06 22.4 In-house 55-157 (178) alignment 
Range on Protein: 346-442
Range on HMM: 55-157/178.0
LNIGYVINVTTHLPLYHYEK---GLFNYKRL--PATDSNKQNLRQYFEEA-FEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVK
 ..| ||..|.    |. ..      .|..|  |  . .|..| . |.||  ||.|. .. .| . .||  || |.  ..  ||.... .   || .  .
kklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafe

GKR
  |
ear
0036941 (Phosphotyrosine protein) phosphatases II 347-464 1.4e-19 66.0 In-house 102-278 (297) alignment 
Range on Protein: 347-464
Range on HMM: 102-278/297.0
NIGYVINVTTHLP----------------------------------LYHYEKGLFNYKR-----------LPATDSNKQNLRQYFEEAFEFIEEAHQ--
|.  ....|.  .                                  | .|    .  .            .  |.    .. ..... ..|||....  
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----CGKGLLIHCQAGVSRSATIVIAYLM--------KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNN
     |.  |.|| |||.||.|...|.||        |. .... .|.|... .|| . ..|... .| |.. .| .
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_DSP23_pd Subfamily DSP23 347-443 8.2e-08 27.0 In-house 31-126 (148) alignment 
Range on Protein: 347-443
Range on HMM: 31-126/148.0
NIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQyFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRP
 . |.. .|.. .          ..||   |     | |  .|  . .|||.. .. . .||  |  |. |..  ||.|. ... ..|   |. .||
gvrylvslteegrphveatpnltlvrlriddyhppaleq.vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp
subfamily_MSG5_pd Subfamily MSG5 349-464 2.1e-19 63.2 In-house 49-162 (165) alignment 
Range on Protein: 349-464
Range on HMM: 49-162/165.0
GYVINVTTHLPLYHYEKGLFNYKRLPATDSNKqnLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPN
  ||||.  ..  ..     .|  .  . . |  . . . .  . |  |.  .| .|.||| |.||||....||.||.  ... |||. .|..   |||.
dlvinvakeindlellvpavkyyhiewehdsk..ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

LNFMGQLLEFEEDLNN
. .. ||.|.|  |..
iglifqlmewevalsk
0051299 (Phosphotyrosine protein) phosphatases II 356-450 8.1e-14 47.2 In-house 170-273 (288) alignment 
Range on Protein: 356-450
Range on HMM: 170-273/288.0
THLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQC----GKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIIS
|.| |.....  .... .  |.   ..  ...|. ..|.......    |.  ..|| |||.|..|.....|.     |. .... .|.|... .|| . 
tnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv

PNLN
....
qtpe
subfamily_Laforin_pd Subfamily Laforin 360-445 1.7e-07 24.3 In-house 71-154 (183) alignment 
Range on Protein: 360-445
Range on HMM: 71-154/183.0
LYHyEKGLfNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPII
||. |.||  |  ||  |   ..  . . .|  ..    . |. . .||.||| ||..||  .|.     ...    |.  |||..
lyk.eegl.ayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPMT1_pd Subfamily PTPMT1 362-462 8.6e-20 65.9 In-house 68-168 (171) alignment 
Range on Protein: 362-462
Range on HMM: 68-168/171.0
HYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEED
...|   .. .|. .|  ..  ..  |.. ||||. .. || . .||.|| .||||.|..||||...... .| |..| ||.||  . . . .| |.|| 
ewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek

L
|
l
PTPlike_phytase Inositol hexakisphosphate 368-424 3e-07 25.2 Pfam-A 93-147 (149) alignment 
Range on Protein: 368-424
Range on HMM: 93-147/149.0
FNYKRLPATDSnKQNLRQYFEEAFEFIEEAhQCGKGLLIHCQAGVSRSATIVIAYLM
..| |.|.||  ..   ..... ...|... .  . |...||||  |. | .. . .
vkYvRipitde.qapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 368-424 3e-07 25.2 In-house 93-147 (149) alignment 
Range on Protein: 368-424
Range on HMM: 93-147/149.0
FNYKRLPATDSnKQNLRQYFEEAFEFIEEAhQCGKGLLIHCQAGVSRSATIVIAYLM
..| |.|.||  ..   ..... ...|... .  . |...||||  |. | .. . .
vkYvRipitde.qapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
0050432 (Phosphotyrosine protein) phosphatases II 375-449 3.6e-12 41.7 In-house 204-285 (308) alignment 
Range on Protein: 375-449
Range on HMM: 204-285/308.0
ATDSNKQNLRQYFEEAFEFIEEAHQC--GKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNL
 |.   ..  ...|. ..|.|.....  |.  ..|| |||.|..|.....|.     |. .... .|.|... .||   ...
ytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 376-447 1.4e-10 36.5 In-house 173-258 (284) alignment 
Range on Protein: 376-447
Range on HMM: 173-258/284.0
TDSNKQNLRQYFEEAFEFIEEAHQC------GKGLLIHCQAGVSRSATIVIAYLMKHT--------RMTMTDAYKFVKGKRPIISP
|.   ..  ...|  .||.......      |.  ..|| |||.|..|.....|...         .... .|.|... .||    
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq
0048567 (Phosphotyrosine protein) phosphatases II 379-443 8e-10 33.3 In-house 52-119 (157) alignment 
Range on Protein: 379-443
Range on HMM: 52-119/157.0
NKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGV---SRSATIVIAYLMKHTRMTMTDAYKFVKGKRP
|   | ...  . .|..    .|| . .|| ||    .|.||.. .||..| ..|  .|.....  ||
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
PTPc_DSPc_SM00012 379-429 5.1e-08 28.4 In-house 16-67 (105) alignment 
Range on Protein: 379-429
Range on HMM: 16-67/105.0
NK--QNLRQYFEEAFEFIEEAHQcGKGLLIHCQAGVSRSATIVIAYLMKHTRM
 .  ... .....  .. ... . .| ...||.|||.|..|.| .... .  .
Peesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqle
0047943 (Phosphotyrosine protein) phosphatases II 382-456 8.6e-14 47.1 In-house 180-265 (273) alignment 
Range on Protein: 382-456
Range on HMM: 180-265/273.0
NLRQYFEEAFEFIEEAHQ------CGKGLLIHCQAGVSRSATIVIAYLM-----KHTRMTMTDAYKFVKGKRPIISPNLNFMGQLL
.  ...|. .||||....       ..  ..|| |||.|..|.....|.     |. .... .|.|... .|| . ...... .| 
gvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
subfamily_PTEN_pd Subfamily PTEN 391-442 9.1e-06 20.8 In-house 106-156 (184) alignment 
Range on Protein: 391-442
Range on HMM: 106-156/184.0
FEFIEEAHQcgKGLLIHCQAGVSRSATIVIAYLMKHTRMTMT-DAYKFVKGKR
 ...|| ..  .   .||.||  |. ....|||.|.. .. . .| .. . .|
ekwleedkk..nvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_CDC14_pd Subfamily CDC14 392-452 5.4e-09 30.3 In-house 254-316 (328) alignment 
Range on Protein: 392-452
Range on HMM: 254-316/328.0
EFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRP--IISPNLNFM
.|.| | ..  .. .||.||. |  |.. .||||| |.| ..|  ...  ||  .|.|  .|.
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfl
subfamily_PTPDC1_pd Subfamily PTPDC1 397-443 4.2e-07 24.6 In-house 111-156 (182) alignment 
Range on Protein: 397-443
Range on HMM: 111-156/182.0
AHQCGkGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRP
| | |  . .|| ||  |   .. .||. ..|.|  .| |.|. |||
alqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp