Gene DUSP12 in Homo sapiens

Synonym: DUSP1, YVH1, DUSP12

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP015_AA protein Get Run
HsapP015_AA_24-173 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0042113 (Phosphotyrosine protein) phosphatases II 18-165 3.2e-19 64.8 In-house 42-238 (245) alignment
Range on Protein: 18-165
Range on HMM: 42-238/245.0
ASRVscagQMLEVQPGLYFGGAAAVAEPD----HLREAGITAVLTVDSEEPSF------------------------------------------KAGPG
|| |     . .. |... ... .   ..     |.| |||..... .||.                                            . .. 
asyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddes

VEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARA--EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKL
 |..  ...|  | ...|||..|.... |. .|.|  ..  |||||.|||.|. ..|.|.||     |.  ...|.|...|.  .| | .....  .|  
revihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye

Y
.
a

0043147 (Phosphotyrosine protein) phosphatases II 19-167 4e-23 77.4 In-house 11-158 (172) alignment
Range on Protein: 19-167
Range on HMM: 11-158/172.0
SRVSCAGQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDsEEPSFKAGPGVEDLWRLFVPALDKPETdLLSHLDRCVAFIGQ--ARAEGRAVLVHCH
| ...   . .. .... ..       . |.| |||.....  |.   . .   ...  |..|  | . . ||..|.... || .  |. .| .|||||.
syldlyyipdrfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs

AGVSRSVAIITAFLMKtDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
|||.|..... |.||.  .|..|.|.. ..  .| |  |... ..|. .. 
aGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek

0044763 (Phosphotyrosine protein) phosphatases II 25-169 7.4e-32 105.8 In-house 21-170 (178) alignment
Range on Protein: 25-169
Range on HMM: 21-170/178.0
GQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAG-----PGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQAR-AEGRAVLVHCHAG
  . |. |||| |.. ... .. |.| |||..... .| . .. .     |  ...  |..|  | ...|||.|....|.|| .|.  .|..|||||.||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVAIITAFLMKTDQLPFEKAYEKLQILKPeAKMNEGFEWQLKLYQAMG
|.|| ... |.|||. .|..|.|.| ..  .| .  |.|.  ||.... . 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_DSP14_pd Subfamily DSP14 25-167 5.1e-29 95.2 In-house 5-142 (157) alignment
Range on Protein: 25-167
Range on HMM: 5-142/157.0
GQMLEVQPGLYFGgAAAVAEPDHLREAGITAVLTVDSEEPSfKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVA
 .. ...| |. . ..|. ... |....||... |  | |. .  ...|   |. ||. |.||..| .|.|. .. | .....| ..|||| |||||| .
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdie...rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAs

IITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
. .|.|||. .|  ..||. ..  .|  . | ||  ||  |  
lclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk

0045098 (Phosphotyrosine protein) phosphatases II 25-169 1.4e-23 79.1 In-house 20-271 (278) alignment
Range on Protein: 25-169
Range on HMM: 20-271/278.0
GQMLEVQPGLYFGGAA-----------------------------------------AVAEPDHLREAGITAVLTVDSEE--------------------
|.. |. |.|| |...                                         . .  . |.| |||..... ...                    
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

----------------------------PSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARA--------------EGRAVLVHCHAGVSR
                            ..     ||. |. |..|  . |....|....... || .|..              .|  |||||.|||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SVAIITAFLMKTD---QLPFEKAYEKLQILKPE-AKMNEGFEWQLKLYQAMG
. ... |.||..    .. ...|...|.  .|  | .|... ..|  .... 
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel

PTEN_1 25-168 4.6e-23 77.0 In-house 42-190 (196) alignment
Range on Protein: 25-168
Range on HMM: 42-190/196.0
GqmlEVQPGLYFGGAAAV-AEPDHLREAGITAVLTVDSEEPS--FKAGPGVEDLWRLF---VPALDKPETDLLSHLDRCVAFIGQARA--EGRAVLVHCH
    |. .||| | .  | |  |.| | |||.|.....||.   .   .  .   ..    .|  | .  .| ...| |. || ....  .|..|||||.
q...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCk

AGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
||..||. .. |.||.. .| ...| | ...  | .  | ..  .|. |.|.
aGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae

subfamily_STYX_pd Subfamily STYX 25-168 3.5e-20 65.7 In-house 10-156 (166) alignment
Range on Protein: 25-168
Range on HMM: 10-156/166.0
GQMLEVQPGLYFGGAAA--VAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFV-PALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSR
 .| |. |||..|  .|   .  ..|.. ||| .. .  .  .    |  .| .| .|    |..  ... .| .  .|| ..  .|  ||||  ||.||
remqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisr

SVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
| |.. |..|.|  | . .|.  .|  .   ..||||  ||| |.|.
saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai

subfamily_DSP19_pd Subfamily DSP19 26-167 1.6e-33 110.2 In-house 11-148 (152) alignment
Range on Protein: 26-167
Range on HMM: 11-148/152.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAgpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
.. ||.| ||.|   ..|. . |.| .|| .| |  . | . .    .|.  | .. ||.|||||||.|.... || .|| .  ||||||.||||||...
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp....kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
. |.|||. .| .|.|.|...  .| .| ||||  ||| |.|
viaylmkkeelsleealelvrearpcikPneGFikqLkeyea

subfamily_DSP6_pd Subfamily DSP6 26-166 1.6e-26 86.7 In-house 13-151 (158) alignment
Range on Protein: 26-166
Range on HMM: 13-151/158.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
  .|. | ||.| | . .. . |.. .|  || | |. |.. .    ..|  | .|. |. ...| ...   ..|| .|| .  .|||||.||.||||..
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfee..sgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
. |.|||. .| ...||. ..  |..   |  |  ||. ..
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfe

subfamily_DSP10_pd Subfamily DSP10 26-165 6.3e-25 81.9 In-house 13-149 (159) alignment
Range on Protein: 26-165
Range on HMM: 13-149/159.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
.. .| | |..| .   |. | |.. .||||| | .. | . ..   |.|    .|. |. . .|  . .  ..|| .|| .|. |||||.||.|||...
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee...ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
. |.|||  .| ...||.  .  .|    | .|  ||. .
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlef

subfamily_DSP8_pd Subfamily DSP8 26-165 5.7e-22 72.0 In-house 14-150 (159) alignment
Range on Protein: 26-165
Range on HMM: 14-150/159.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
.. .. . ||.|    | . . |.. ||. || .. . |. .  . ..    | ||  || . .||  .|. | || .|..|   ||||..|| ||| ..
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk...flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
. |..||| .. ...||. ..  .|  . |  |. ||  |
aiayimktlemsldeayrfvkekrptispnlnflgqLley

subfamily_DSP3_pd Subfamily DSP3 26-166 1.5e-19 64.2 In-house 10-154 (162) alignment
Range on Protein: 26-166
Range on HMM: 10-154/162.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEepSF---KAGPGVE---DLWRLFVPALDKPETDLLSHLDRCVAFIGQARAE-GRAVLVHCHAG
.. || |.|| |..|.  . ..|...||| ||       .|   ..|.      ..  | ... |.||.||  . .. ..|| .| ..    |||||..|
evdevypklyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvG

VSRSVAIITAFLMKTDQLPFEKAYEKLQIlKPEAKMNEGFEWQLKLYQ
|||| ... |.|| . ..   .| .. .  | |   ||||  ||. ..
vsRsatlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeld

subfamily_DSP12_pd Subfamily DSP12 27-181 4.8e-58 189.9 In-house 2-155 (155) alignment
Range on Protein: 27-181
Range on HMM: 2-155/155.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEE-PSFKAGPGVEDlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
. ...||||.||..||.|...|.|..||.||.|..|| |..|. .|  .  ..|...||.||.|.|||||..|.|| .|..|..||||||.|||||||.|
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvs..tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvti

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMGYEVDTSSAIYKQ
..|.|||...|..|||.....  |||...|||| .||||...||..||||.  ||.
viAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayke

PTPc_motif_SM00404 27-167 6.7e-30 98.8 In-house 2-139 (140) alignment
Range on Protein: 27-167
Range on HMM: 2-139/140.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. .. |.||.|.. .  .|. | . |||.|. | .| .  |. .|..   .| .|  |. ...|. .||....|| .|...|..||||| ||||||...|
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfq...ilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
.|.||...||  ..||| ..  .|  . |..|  ||  |. 
iaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

0048076 (Phosphotyrosine protein) phosphatases II 27-167 7.1e-30 99.0 In-house 4-140 (145) alignment
Range on Protein: 27-167
Range on HMM: 4-140/145.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKagpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. |. ||||.|.  .. . ..|.. |||.||.. ||.. ..     .... |..|  | .. |||..|.....|| .|..||. |||||.|||.|. ...
pseilpglylgslptaldlellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
 |.||.. ....|.|.|...   | | .|.|.  .|.... 
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 27-166 4.6e-29 96.4 In-house 4-141 (144) alignment
Range on Protein: 27-166
Range on HMM: 4-141/144.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEepSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. |. ||||.|.  .. . ..|.. |||.|... .|    .. ...| .  |..|  | .  |||..|.....|| .|..||. |||||.|||.|. ...
pseilpglylgslptaldlellkklgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
.|.|||. .|..|.|.. ..   | | .|.|. ..|..|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleye

subfamily_DSP15_pd Subfamily DSP15 27-168 5.8e-29 95.1 In-house 2-138 (151) alignment
Range on Protein: 27-168
Range on HMM: 2-138/151.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSeepsfKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. .| |||| |.     . . |.|  || .|.|        | . ..|.  ....| | |...| .... .| || ..| .. .||||| ||||||| ..
iskvlpglylgnfrdskdeelLkeknithilsvhd.....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlv

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
.|.||   .| ...| | ..  .  |. | ||. ||| |. .
vaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt

0046846 (Phosphotyrosine protein) phosphatases II 27-167 5.9e-23 77.0 In-house 12-170 (176) alignment
Range on Protein: 27-167
Range on HMM: 12-170/176.0
MLEVQPGLYFGGAA----------AVAEPDHLREAGITAVLTVDSEEPS-------FKAGPGVEDLWRLFVPALDKPETDLlSHLDRCVAFIGQARAEGR
. .. ..|..|..             .  ..|.|.|||||... .|          .      ...  |..|  |    || ..|.....|| .|. ||.
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkegg

AVLVHCHAGVSRSVAIITAFLMKT-DQLPFEKAYEKLQILKP-EAKMNEGFEWQLKLYQA
 |||||.||..|. ... |.|...  .|. |.|.....  .|  |  .... ..|. .  
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel

0037934 (Phosphotyrosine protein) phosphatases II 27-166 1.9e-19 65.6 In-house 39-238 (243) alignment
Range on Protein: 27-166
Range on HMM: 39-238/243.0
MLEVQPGLYFGGA--------AAVAEPDHLREAGITAVLTVDSEE------------------------------------------PS-FKAGPGVEDL
. .| |.|. ...        .. .  . | | |||..... ...                                          ..  .    |  .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

WRLFVPALDKPE--TDLLSHLDRCVAFIGQ-----ARAEGRAVLVHCHAGVSRSVAIITAFLMKTD-QLPFEKAYEKLQILKPE-AKMNEGFEWQLKLYQ
..| .|  . |.  .|||..|| . .|| .     |. .|. |||||.|||.|. ..|.|.||..  ....|.|...|.  .|  |  .... ..|  . 
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal





0041856 (Phosphotyrosine protein) phosphatases II 28-173 3.2e-23 77.7 In-house 20-176 (182) alignment
Range on Protein: 28-173
Range on HMM: 20-176/182.0
LEVQPGLYFGGAAA--------------VAEPDHLREAGITAVLTVDsEEPSFKAGPGVEDLWRLFVPALDKPETDllshLDRCVAFIGQARAEGRAVLV
 .. ..|| |.  |               .  . |.| |||.....  ||. .      . .  |..|  | . .|    || ...|| ....||..|||
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlV

HCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKP--EAKMNEGFEWQLKLYQAMGYEVD
||.|||.|. ... |.|||. ....|.|.. ..  .|     .| .|  ||.|.. . . ..
HCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

0049260 (Phosphotyrosine protein) phosphatases II 28-165 9.3e-21 69.5 In-house 9-145 (152) alignment
Range on Protein: 28-165
Range on HMM: 9-145/152.0
LEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPG--VedlWRLFVPALDKPETDLLSHLDRCVAFIGQ-ARAEGRAVLVHCHAGVSRSVA
 |. .... |.  .    . |.| |||..... ....  | .          |..|  | .  ||  .|. .. || . |. .|  |||||.|||.|. .
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

IITAFLMKtDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
.. |.||.  ....|.|.. ..  .| |  |.|. ..|. .
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyef

0051429 (Phosphotyrosine protein) phosphatases II 28-174 5.3e-18 61.1 In-house 17-229 (272) alignment
Range on Protein: 28-174
Range on HMM: 17-229/272.0
LEVQPGLYFGGAA----AVAEPDHLREAGITAVLTVDSEE--PSFKAGPGVEDLWRLFVPALDKPETDLLSHL---------------------------
 .| ||... ...     .|. ..|.| ||...... |||  ...|  .  ... .|..| ||  ... | .                            
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------DRCVAFIGQARAeGRAVLVHCHAGVSRSVAIITAFLMKtDQLP--------------FEKAYEKLQILKPEAKMNEGFE
                     . ..... . .. |..|||||.||..|.  .. ..|.   ...               |.|.|.|.   | |  .|.. 
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

WQLKLYQAMGYEVDT
..|  . .  ..  .
lflyeallellrsll

subfamily_DSP1_pd Subfamily DSP1 29-167 3.2e-24 79.9 In-house 20-154 (163) alignment
Range on Protein: 29-167
Range on HMM: 20-154/163.0
EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgvedLWR-LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIIT
.... ||.|..   .. . |.. ||||.| | .| . .        |..   ..  |.|. |. ..... . || ......  ||.||.||.||| ... 
kildfLylGsetvasnleiLkslgitailnvskeldnvfed.....lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
|.||||... .|.|..  .  ..  . | ||  ||. |. 
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek

subfamily_LRR-DSP_pd Subfamily LRR-DSP 29-167 6.2e-22 71.9 In-house 122-256 (263) alignment
Range on Protein: 29-167
Range on HMM: 122-256/263.0
EVQPGLYFGGAAAVAEPDHLREAGITAV-LTVDSEEPSFkagPgveDLWRLFV--PALDKPETDLLSHLDRCVAFIGQARAEGrAVLVHCHAGVSRSVAI
|. ..|..||  .  .   |.. |.| . |.|   || |   |   .|.. ..   . | .| |.  |...  ||| . | .|  ||||| |||||| ..
eiidklflGgldsannksilkdlgvthillavadfePlf...P...klfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstl

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
. ..||| ..| |..|..  .  .|. . | ||  ||| |..
visylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek

subfamily_STYXL1_pd Subfamily STYXL1 29-166 1.5e-19 63.7 In-house 13-150 (157) alignment
Range on Protein: 29-166
Range on HMM: 13-150/157.0
EVQPG-LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFK-AGPGVedLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
|| || || |      .|   ..  . |.. | ..   .  . ..|     | ..  |..|.|||..|.. | ||.. . ||..|||  . |.|||.|.|
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadv..akllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
 |.||   .. ..|||..|.  |.  | | .|  ||. ..
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWe

0036282 (Phosphotyrosine protein) phosphatases II 29-165 1.7e-17 59.1 In-house 14-165 (174) alignment
Range on Protein: 29-165
Range on HMM: 14-165/174.0
EVQPGLYFGGAAAVaEPDHLREAGITAVLTVDSEEPS-----------FKAGPGVEDLWRLFVPALDKPETDLLShLDRCVAFIGQARAE--GRAVLVHC
.. |.|. |.. .    . |.| |||.|... .|..            ..  .  ...  |..|  |  . ||   |...| |. .|..|  |. |||||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

HAGVSRSVAIITAFLMKTDQL-PFEKAYEKLQILK---PEAKMNEGFEWQLKLY
.|||.|. ... |.||.. .| ....|.. .. |.   | .  ....  .|  .
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf

0051082 (Phosphotyrosine protein) phosphatases II 29-160 2.8e-17 58.2 In-house 10-144 (151) alignment
Range on Protein: 29-160
Range on HMM: 10-144/151.0
EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVED--LWRLFVPALDKPETDLLSHLDRCVAFIGQARAE-GRAVLVHCHAGVSRSVAI
 | .||| .|.   .  . |.| ||...... |||.  .    ...  .  | .| || |...|  ..| ...|. ....  .  |||||.||..|. ..
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

ITAFLMKtDQLPFEKAYEKLQILKP-EAKMNEGFEW
. ..||.  ....|.|.| ...  |     |..|  
valylml.lgvsleealeeyrlkrpgvvqpnqqflf

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 30-164 3e-18 59.8 In-house 10-142 (148) alignment
Range on Protein: 30-164
Range on HMM: 10-142/148.0
VQPG-LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITA
.... |. |     |. . |.. |.|.. .   | .   .  |.|    | |.  |||. || .  .  .||. .|..||| ||||.. ||||| |.  .
ikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgie...YlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

FLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKL
.|.....   ..|..  .  ..  . | ||  ||  
wlidfkrvslkealalvkskrryvdpnlgfLkqLae

subfamily_Slingshot_pd Subfamily Slingshot 31-168 1.5e-22 73.7 In-house 23-156 (169) alignment
Range on Protein: 31-168
Range on HMM: 23-156/169.0
QPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAgpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFL
   .|.|     .. ..|.| |.. .| |  |  .| .    |..  | .   |..|||||.. ..   || .|...|  |||||  ||||| ... |. 
fdhvylGsewnasnleelkengveyilnvtkeidnffp....ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
||. .| .|.|.| ..  .  .| |.||  ||. |. .
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGi

subfamily_MKPLT_pd Subfamily MKPLT 33-168 8.7e-16 51.9 In-house 28-159 (164) alignment
Range on Protein: 33-168
Range on HMM: 28-159/164.0
GLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSfkAGPgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMK
 || | |  . .  .|..  || .. |  |. .  | |  . .  | |   |.... | |.|.|   |. .|   |  |||||  |.||| ..  |||.|
tlylGnakhatnekvlkdlkithivnvsqekkd..afp..ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

TDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
  .  ...||| |.  .  .. | ||  ||  .. .
skgwtlkeayeylkerrsivapnrGflkqlakfeel

subfamily_MKPLV_pd Subfamily MKPLV 33-168 8.7e-16 51.9 In-house 28-159 (164) alignment
Range on Protein: 33-168
Range on HMM: 28-159/164.0
GLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSfkAGPgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMK
 || | |  . .  .|..  || .. |  |. .  | |  . .  | |   |.... | |.|.|   |. .|   |  |||||  |.||| ..  |||.|
tlylGnakhatnekvlkdlkithivnvsqekkd..afp..ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

TDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
  .  ...||| |.  .  .. | ||  ||  .. .
skgwtlkeayeylkerrsivapnrGflkqlakfeel

DSPc Dual specificity phosphatase, catalytic domain 34-166 1.6e-27 90.9 Pfam-A 1-131 (133) alignment
Range on Protein: 34-166
Range on HMM: 1-131/133.0
LYFGGAAAVAePDHLREAGITAVLTVDSEEPSFkAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKT
||.|.. .   .. | . |||.|. | .| |        ..  .| .|  |. ||.. ..|...|.|| .|...|. ||||| ||.||| ..|.|.||||
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

DQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
..|. ..||| ..  ..    |.||  ||  |.
knlslneAyefvkerrskispnagflrqLleye

DSPc Dual specificity phosphatase, catalytic domain 34-166 1.6e-27 90.9 In-house 1-131 (133) alignment
Range on Protein: 34-166
Range on HMM: 1-131/133.0
LYFGGAAAVAePDHLREAGITAVLTVDSEEPSFkAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKT
||.|.. .   .. | . |||.|. | .| |        ..  .| .|  |. ||.. ..|...|.|| .|...|. ||||| ||.||| ..|.|.||||
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

DQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
..|. ..||| ..  ..    |.||  ||  |.
knlslneAyefvkerrskispnagflrqLleye

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 34-142 7.6e-16 51.5 In-house 6-114 (145) alignment
Range on Protein: 34-142
Range on HMM: 6-114/145.0
LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKT
|| | |    .   |.| ||. .. . . .         |..  |.. | |    ||  |.|    || . . ||  |.||| |||||||..  ||||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

DQLPFEKAY
 .. . .| 
cnmtlseaa

0040439 (Phosphotyrosine protein) phosphatases II 47-167 1.3e-17 59.7 In-house 73-243 (249) alignment
Range on Protein: 47-167
Range on HMM: 73-243/249.0
HLREAGITAVLTVDSEEPSFKAG---------------------------------------PGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARA-
 |.| |||..... |...  . .                                          |..  | .. .| |.... .... ...|| ..|  
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
     .|  |||||.|||.|. ..|.|.||     |. ....| |...|.  .| | .|...  .|  . .
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

subfamily_DSP23_pd Subfamily DSP23 47-151 3.2e-07 25.1 In-house 26-127 (148) alignment
Range on Protein: 47-151
Range on HMM: 26-127/148.0
HLREAGITAVLTVDS-EEPSFKAGPGVEdLWRLFVPALDKPETDllsHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKL
.| . |.  ....    .|  .| |..  | || ..    |  .    ... |  . .| . . || |||  |  |. .... .|.|  .|   .|  ..
ylldlgvrylvslteegrphveatpnlt.lvrlriddyhppale...qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

QILKPE
. |.| 
rrlrpg

0045450 (Phosphotyrosine protein) phosphatases II 49-165 1.2e-15 53.5 In-house 128-299 (307) alignment
Range on Protein: 49-165
Range on HMM: 128-299/307.0
REAGITAVLTVDSEEPS-----------------------------FkagpgVEDLWRLFVPALDK-----------------PETDLLSHLDRCVAFIG
.| |.|..... ....                                     ...... ..  |.                 |.... .... ...|| 
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

QARA------EGRAVLVHCHAGVSRSVAIITAFLMKTDQ--------LPFEKAYEKLQILKPEAKMNEGFEWQLKLY
..|.      .|  |||||.|||.|. ..|.|.||..          .....|...|.  .| |  |...  .|  .
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

0040438 (Phosphotyrosine protein) phosphatases II 73-168 2e-14 49.1 In-house 154-274 (317) alignment
Range on Protein: 73-168
Range on HMM: 154-274/317.0
EDLWRLFVPALDK----------------PETDLLSHLDRCVAFIGQARAE----GRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQI
..   . ..  |.                |. .. ...| ...|. ..|.     |  |||||.|||.|. ..|.|.||     |. .. .|.|...|. 
agitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelre

LKPEAKMNEGFEWQLKLYQAM
 .| |  ....  .|  . ..
qRpgavqtpeqyrflydalle

0043336 (Phosphotyrosine protein) phosphatases II 75-165 1.5e-12 43.1 In-house 178-272 (278) alignment
Range on Protein: 75-165
Range on HMM: 178-272/278.0
LWRLFVPALDKPEtDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
.. | .|  . || .| ..|| . |.. . . .. .|||||.|||.|. ..|...|.     |.  ...|.|...|.  .| | ... . ..|  .
yhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

0049772 (Phosphotyrosine protein) phosphatases II 77-168 1.5e-23 79.4 In-house 183-272 (314) alignment
Range on Protein: 77-168
Range on HMM: 183-272/314.0
RLFVPALDkPETDLLSHLDRCVAFIGQArAEGRAVLVHCHAGVSRSV-AIITAFLMKTDQLPFEKAYEKLQILKPeAKMNEGFEWQLKLYQAM
 | .|  | ....||...|....|| .|  .|..|||||.||..|.  ....|.|||  ....|.|.| ..   | ...|.||  ||..|. .
ylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi

0039614 (Phosphotyrosine protein) phosphatases II 78-167 1.7e-15 52.7 In-house 189-286 (297) alignment
Range on Protein: 78-167
Range on HMM: 189-286/297.0
LFVPALDKPETDLLSHLDRCVAFIGQARA---EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
....  |    ..|..|.. . .. .|.|   .|. |||||.|||.|. ..|.|.||     |. .. ...|...|.  .| | ..... ..|  . .
qytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

subfamily_PTPMT1_pd Subfamily PTPMT1 78-166 2.7e-14 48.0 In-house 77-165 (171) alignment
Range on Protein: 78-166
Range on HMM: 77-165/171.0
LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
| ..  |  |.  | .| . | || . . .|. | |||.|| .|| ......|||...|  |.| . |.  ..  ....    .|. |.
lqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye

subfamily_Laforin_pd Subfamily Laforin 78-136 6.9e-07 22.3 In-house 80-138 (183) alignment
Range on Protein: 78-136
Range on HMM: 80-138/183.0
LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQL
...|  |      .  | ..| ..     .|  | ||| ||| || ||.  ||.   . 
iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgw

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 81-166 9e-16 51.6 In-house 62-149 (154) alignment
Range on Protein: 81-166
Range on HMM: 62-149/154.0
PALDKPETDLLSHLDRCVAFIGQAR--AEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
   |... |.. .||..  || .|    |   ||||...||||| |.. ..||.  .... .|.| |.  ..  | |.||  ||. ..
elfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleife

PTPc_DSPc_SM00012 82-137 7.2e-07 24.7 In-house 12-68 (105) alignment
Range on Protein: 82-137
Range on HMM: 12-68/105.0
ALDKPE--TDLLSHLDRCVAFIGQARAeGRAVLVHCHAGVSRSVAIITAFLMKTDQLP
   .||  ...|..|. .  .  ..   .  |.|||.|||.|.  .... ..  .   
dhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqlek

0036941 (Phosphotyrosine protein) phosphatases II 84-168 4.9e-13 44.5 In-house 177-275 (297) alignment
Range on Protein: 84-168
Range on HMM: 177-275/297.0
DKPETDLLSHLDRCVAFIGQARA------EGRAVLVHCHAGVSRSVAIITAFLM--------KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
. |. .. .. . ...|| ..|       .|  |||||.|||.|| ..|.|.||        |. .... .|. ||   .| |  ....  .|  . ..
gwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle

0051299 (Phosphotyrosine protein) phosphatases II 85-152 6.8e-09 31.1 In-house 192-268 (288) alignment
Range on Protein: 85-152
Range on HMM: 192-268/288.0
KPETDLLSHLDRCVAFIGQARAE----GRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEA
 |. .  .... ...|. ..|      |  |.|||.|||.|. ..|...|.     |.  . ...|...|   .| .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm

0050432 (Phosphotyrosine protein) phosphatases II 86-167 3.9e-09 31.7 In-house 208-294 (308) alignment
Range on Protein: 86-167
Range on HMM: 208-294/308.0
PETDLLSHLDRCVAFIGQARAE--GRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEakMNEGFEWQLKLYQA
|. .  .... ...|. ..|    |  ..|||.|||.|. ..|.. |.     |.  . ...|. ||   .|   | ...|  | ||.|
pdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg..mvqtpeqylflyra

0038934 (Phosphotyrosine protein) phosphatases II 88-165 8.7e-14 47.1 In-house 96-172 (194) alignment
Range on Protein: 88-165
Range on HMM: 96-172/194.0
TDLLSHLDRCVAFIGqARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
...| .  . | ..  .. .| .|.|||.||..|.  .. |.|... ... |.|.. ... .| | .| ..  .|  .
leillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr

0047943 (Phosphotyrosine protein) phosphatases II 89-159 1.2e-09 33.5 In-house 180-261 (273) alignment
Range on Protein: 89-159
Range on HMM: 180-261/273.0
DLLSHLDRCVAFIGQARA------EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFE
.  ..|. .. || ..|       ..  |.|||.|||.|. ..|...|.     |. .. ...|. .|.  .| . ... . 
gvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy

0046845 (Phosphotyrosine protein) phosphatases II 89-151 1.7e-07 26.4 In-house 179-255 (284) alignment
Range on Protein: 89-151
Range on HMM: 179-255/284.0
DLLSHLDRCVAFIGQAR------AEGRAVLVHCHAGVSRSVAIITAFLMKTD--------QLPFEKAYEKLQILKPE
.  ....  ..|. ..|        |  ..|||.|||.|. ..|.. |...          .....|. .|   .| 
gvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg

subfamily_MSG5_pd Subfamily MSG5 91-166 3.5e-12 39.7 In-house 82-157 (165) alignment
Range on Protein: 91-166
Range on HMM: 82-157/165.0
LSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
   | |    |  |..... .||||  |.||| ..| |..||  .| ...||.||.    . . . |. .||  ..
vkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe

subfamily_PTPDC1_pd Subfamily PTPDC1 98-151 8.6e-07 23.6 In-house 105-157 (182) alignment
Range on Protein: 98-151
Range on HMM: 105-157/182.0
VAFIGQARAEGrAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPE
|  . .|  || .| ||||||  |   .|...|. ...|  ||| ....  .|.
vkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk

0048567 (Phosphotyrosine protein) phosphatases II 100-166 2.9e-07 25.0 In-house 66-135 (157) alignment
Range on Protein: 100-166
Range on HMM: 66-135/157.0
FIGQARAEGRAVLVHCHAGV---SRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
|... . .|.|. |||.||    .|.. .| ..|..  ... |.|.. |.|  |  ..     . | ||.
flkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn