Gene DUSP14 in Homo sapiens

Synonym: MKP-L, MKP6, DUSP14

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP016_AA protein Get Run
HsapP016_AA_24-169 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 13-170 2e-44 146.7 In-house 9-175 (178) alignment
Range on Protein: 13-170
Range on HMM: 9-175/178.0
LMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQ---------FEYVKVPLADMPHAPIGLYFDTVADKIHSVS-R
|. ....  .|  .. .|.  |.||    |... ||.. |||.||| | |.... ..          ..|...|. |..  ..  .|. . . |...  .
lsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

KHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPvIRPNVGFWRQLIDYERQLFGKST
|.|..|||| |||.||.||..||||| ....| ||...|..||| | || |..|||...|..|...|.
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd

0046846 (Phosphotyrosine protein) phosphatases II 22-167 2.2e-30 101.1 In-house 7-174 (176) alignment
Range on Protein: 22-167
Range on HMM: 7-174/176.0
GDIGGIAQITSSLFLGRGS----------VASNRHLLQARGITCIVNATIEI-----------PNFNWPQFEYVKVPLADMPHAPIgLYFDTVADKIHSV
|. ... .|. .|.||             .|.. ..|.  |||..|| | |.           | .  ....|  .|  |.   ..  ..... . |...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirea

SRKHGATLVHCAAGVSRSATLCIAYLMKF-HNVCLLEAYNWVKARRP-VIRPNVGFWRQLIDYERQLFG
 ...| .|||| ||..|..||..|||..  ... ..||. .|...||  . .. ...|.| ..|..|..
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk

subfamily_DSP14_pd Subfamily DSP14 23-177 7.9e-72 234.3 In-house 3-156 (157) alignment
Range on Protein: 23-177
Range on HMM: 3-156/157.0
DIGGIAQITSSLFLGrGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLC
.. ...|||.||||. |..|....||....||.|.|.|.|.|| .....|.||||..|.|.| .  .||.|||||..|..|.|.|||||.|||||||.||
elaalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

IAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTP
.|||||.....| |||..||..||.||||||||.||||||..|.|||.||||..|
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvdsp

subfamily_DSP19_pd Subfamily DSP19 26-165 8.8e-41 133.8 In-house 11-150 (152) alignment
Range on Protein: 26-165
Range on HMM: 11-150/152.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
 ..... .|.||  .||.... |. ..|| |.| ....||.   .|.|..... | | . .  |.... | |... .|.|| |||| |||||||.. |||
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
||| ....| ||.. |.. || |.|| ||..|| .|| .|
lmkkeelsleealelvrearpcikPneGFikqLkeyeael

0041856 (Phosphotyrosine protein) phosphatases II 26-172 6.6e-37 122.2 In-house 18-179 (182) alignment
Range on Protein: 26-172
Range on HMM: 18-179/182.0
GIAQITSSLFLGRGSV--------------ASNRHLLQARGITCIVNATieiPNFNWPQF------EYVKVPLADMPHAPiglyFDTVADKIHSVSRKHG
.. .|. .|.||                  |.. ..|. .|||.|||.|   .   ||..      .|...|  |..  .    .|.. | |. | ...|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleegg

ATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRP--VIRPNVGFWRQLIDYERQLFGKSTVK
..|||| |||.|..||..||||| ..| | ||...|. |||  ||.|| .|..||. .|..|..| ..|
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk

subfamily_Slingshot_pd Subfamily Slingshot 26-165 1.5e-35 116.1 In-house 18-157 (169) alignment
Range on Protein: 26-165
Range on HMM: 18-157/169.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
  ..|   ..||    ||| . |. .|.. |.| | || ||   .|||... . | ... .  |...  . |. . .|.   ||||  ||||||.  |||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
 || ... | ||...|| || ||.|| ||..||  ||  |
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

0045098 (Phosphotyrosine protein) phosphatases II 26-166 7e-35 116.2 In-house 21-272 (278) alignment
Range on Protein: 26-166
Range on HMM: 21-272/278.0
GIAQITSSLFLGRGS-----------------------------------------VASNRHLLQARGITCIVNAT------------------------
 . .|| .|.|| ..                                         ||.. ..|.  |||.||..|                        
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

----------------------------IEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSR--------------KHGATLVHCAAGVSRS
                             ......  .. |. .|  . |. ||  .|. . . |... .              ..| .|||| |||.|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

ATLCIAYLMKFH---NVCLLEAYNWVKARRPV-IRPNVGFWRQLIDYERQLF
.||..||||. .   .|.||||..... .||  . .| ...|.|......|.
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_DSP8_pd Subfamily DSP8 26-166 1.6e-33 109.5 In-house 14-155 (159) alignment
Range on Protein: 26-166
Range on HMM: 14-155/159.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFN-WPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIA
|. .|.  |.||   .. ...||.. ||. ..||  . |. .  .. ....||. |  .  .  .||.  . |  . ...|  |||. || |||||. ||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|.||  .. | |||..|| .||.| ||. |  ||..||..| 
yimktlemsldeayrfvkekrptispnlnflgqLleyekelk

subfamily_DSP15_pd Subfamily DSP15 26-164 1.4e-30 100.4 In-house 1-138 (151) alignment
Range on Protein: 26-164
Range on HMM: 1-138/151.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATiEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
|| ..   |.||   ......||. . || |..   . ..   ...||  ....| |.| .  .|.   . ||.   | .. ||||.||||||.||..||
giskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
||   ..   .| . .||.| |  ||.|| ||| .||..
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt

subfamily_DSP1_pd Subfamily DSP1 27-166 1.5e-45 149.2 In-house 18-157 (163) alignment
Range on Protein: 27-166
Range on HMM: 18-157/163.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYL
. .|.  |.||  .||||...|.. ||| |.|.. |..|.    ||| |..| | |.| | |.|..| . |..| .|.|  |.||.||.|||.|||.|||
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|| ..| | ||...|| ||..|.||.|| .||..||..| 
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

subfamily_DSP10_pd Subfamily DSP10 27-166 8.4e-41 133.5 In-house 14-154 (159) alignment
Range on Protein: 27-166
Range on HMM: 14-154/159.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWP-QFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
..|. . |||| .  |.. ..|.  .||...| | ..||.    ...| ..|. |  .  .  ||.   . |. . .|    |||| ||.|||||. |||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|||  |. | .||..|| .||.| ||..|  ||...|..| 
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln

PTPc_motif_SM00404 27-163 1.4e-40 133.5 In-house 2-139 (140) alignment
Range on Protein: 27-163
Range on HMM: 2-139/140.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPN-FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
. .|.  |.||  | |.|. ||.. ||| ..|.| |...  . ..|.....|| |   ...  |.| |.| |... .|.|. ||||.|||||||||.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYER
||. ... | |||. || ||| |.||..|.||||.||.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek

0048076 (Phosphotyrosine protein) phosphatases II 27-166 5.9e-37 121.9 In-house 4-143 (145) alignment
Range on Protein: 27-166
Range on HMM: 4-143/145.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYL
...|. .|.||   .|... ||.  |||...| | |....    ..|. .|. |..  ..  ..... . |... ...| .|||| |||.|..||..|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|. ..| | ||...|...|| . ||.|..|.|...|..|.
mlllgvsleealelvrsqrpgavpnpgqlrflyefelell

0048179 (Phosphotyrosine protein) phosphatases II 27-165 7.3e-36 118.4 In-house 4-144 (144) alignment
Range on Protein: 27-165
Range on HMM: 4-144/144.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQF--EYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIA
...|...|.||   .|..  ||.. |||...| | | ..  . ..  .|...|. |..  ..  ..... . |... ...| .|||| |||.|..||..|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
|||| ....| ||...|..||| . || |..|.|..||..|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll

subfamily_DSP12_pd Subfamily DSP12 27-164 4.4e-31 102.4 In-house 2-142 (155) alignment
Range on Protein: 27-164
Range on HMM: 2-142/155.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIE-IPNFN--WPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCI
. .|.  |.||  . . . .||.  .|| ..  . | .|...  . . .. .....|.|...|  ..|.. | |..   ..|| ||||.||||||.|..|
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
||||| ... | .|.. ||. .| |.|| || .||  .|. 
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm

0051082 (Phosphotyrosine protein) phosphatases II 27-162 4.3e-28 93.2 In-house 8-150 (151) alignment
Range on Protein: 27-162
Range on HMM: 8-150/151.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQF------EYVKVPLADMPHAPIGLYFDTVADKIHSVSRK-HGATLVHCAAGVSRSA
. ..|. |... |  | .  ||.  ||..||| . | .. ..|..      |.. .|. |.|  .. |.||.|.. .. . .| .| .|||| ||..|..
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TLCIAYLMKfHNVCLLEAYNWVKARRP-VIRPNVGFWRQLIDYE
||...|||. ..|.| ||.......|| |..|| .|. ||....
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall

0036282 (Phosphotyrosine protein) phosphatases II 27-165 7.5e-28 92.8 In-house 12-169 (174) alignment
Range on Protein: 27-165
Range on HMM: 12-169/174.0
IAQITSSLFLGRGSVAsNRHLLQARGITCIVNATIEIPN---------------FNWPQFEYVKVPLADMPHAPIGLyFDTVADKIHSVSRK--HGATLV
.  ||. |..| |  | . ..|.  |||..|. . |...               .    ..|...|  |.   ..   .... . ....  .  .| .||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCAAGVSRSATLCIAYLMKFHNV-CLLEAYNWVKARR---PVIRPNVGFWRQLIDYERQL
|| |||.|..||..||||. .    | .|...|...|   | . .. ...|.| ..|..|
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

subfamily_DSP6_pd Subfamily DSP6 28-165 2.2e-35 115.5 In-house 15-154 (158) alignment
Range on Protein: 28-165
Range on HMM: 15-154/158.0
AQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNF--NWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
..|.. |.||    |||. .|.  .|  ..| | ..||.  . ....|...|. |  .. .  .|    . |    .|. . |||| ||.||| |...||
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlay

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
||| ... | .||..||.|.. | ||  |  ||.|.||.|
lmkklalslndaydlvkkrksnisPnfnfmgqlldfersl

subfamily_DSP3_pd Subfamily DSP3 28-166 3.9e-32 105.1 In-house 12-158 (162) alignment
Range on Protein: 28-166
Range on HMM: 12-158/162.0
AQITSSLFLGRGSVASNRHLLQARGITCIVNATIE----I---PN-FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHS-VSRKHGATLVHCAAGVSRS
 ... .|..|  .||.... |.. ||| ..||.      .   .. ..  ...|. ... |.|.. .  ||.|.|. |.. .|.|.|  ||||..|||||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

ATLCIAYLMKFHNVCLLEAYNWVKARRPvIRPNVGFWRQLIDYERQLF
||| .|||| .... | || . |...|  |.|| || .||......| 
atlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelk

subfamily_STYX_pd Subfamily STYX 28-173 7.7e-25 80.9 In-house 13-165 (166) alignment
Range on Protein: 28-173
Range on HMM: 13-165/166.0
AQITSSLFLGRGSVASN--RHLLQARGITCIV------NATIEIPNFNwPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSA
 .|   ||||  | | .   . |. .||| ||      .|..  |||.  .| |. . .|| .   |  |. || . | .  .| |  |||  ||.||||
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfp.drfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKM
.| |||.|. . .   ||. .|. ||  | || || .|| .||   . | |.|.
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltikl

subfamily_LRR-DSP_pd Subfamily LRR-DSP 29-167 3.7e-31 102.2 In-house 122-260 (263) alignment
Range on Protein: 29-167
Range on HMM: 122-260/263.0
QITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKV-PLADMPHAPIGLYFDTVADKIHSvSRKHGATLVHCAAGVSRSATLCIAYLM
.|   ||||    | |. .|.  |.| |. |  ..  .    | |. .  . |...| |  .|. .   |..  ||.|  |||| ||||||.|| |.|||
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafiee.GrkkGGvlvhcraGvsrsstlvisylm

KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFG
| ... . ||.. |. .|| |.|| ||  ||  ||..|| 
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc

PTEN_1 29-166 2.7e-28 94.1 In-house 43-192 (196) alignment
Range on Protein: 29-166
Range on HMM: 43-192/196.0
QITSSLFLGRGSVA-SNRHLLQARGITCIVNATIEIPN---------FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSR--KHGATLVHCAAGVS
.|  .|..|. . . .... |...|||..|| . | ..         |.  ..|| ..|  | .  ..   || ... |.....  .... ||||.||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
||.|...||||. ..    ||  .|...||...|| .....|. |...|.
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell

0042113 (Phosphotyrosine protein) phosphatases II 29-166 1.2e-27 92.3 In-house 49-243 (245) alignment
Range on Protein: 29-166
Range on HMM: 49-243/245.0
QITSSLFLGRGSVASNRH----LLQARGITCIVNAT------------------------------------------------IEIPNFNWPQFEYVKV
.||  .... |  ... .    .|.  |||.||. |                                                 . . ..  .. |. .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

PlaDMPHAPIGLYFDTVADKIHSVSR--KHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|  |.. ...  ... . . .... .  ..| .|||| |||.|..|...||||     | ..|.| ||. ... .|| .... ...|.|......|.
p..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0049260 (Phosphotyrosine protein) phosphatases II 30-165 4.6e-32 106.2 In-house 11-149 (152) alignment
Range on Protein: 30-165
Range on HMM: 11-149/152.0
ITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPN---FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHS-VSRKHGATLVHCAAGVSRSATLCIAY
..  ...|. ..|.. ..|.  |||.||. | . ..   . .  ..|  .|  |..  ..  ... . . |.    .|.| .|||| |||.|..||..||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMKfHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
||. ..| |.||...|...||.. || |..|.| ..|..|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

0037934 (Phosphotyrosine protein) phosphatases II 30-166 5.7e-29 96.8 In-house 42-242 (243) alignment
Range on Protein: 30-166
Range on HMM: 42-242/243.0
ITSSLFLGRG--------SVASNRHLLQARGITCIVNATIEI---------------------------------------------PNFNWPQFEYVKV
.|  |... |         .||. ..|.  |||.||. | ..                                             ... .  . |  .
vtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

PLAD----MPHAPIGLYFDTVADKIHS-----VSRKHGATLVHCAAGVSRSATLCIAYLMKFH-NVCLLEAYNWVKARRPV-IRPNVGFWRQLIDYERQL
|  |      ....  ..| | . |..     .  ..| .|||| |||.|..||..||||. . .| |.||.......||  . .. ...|.|......|
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel

F
.
l

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 30-165 1.6e-26 86.5 In-house 6-152 (154) alignment
Range on Protein: 30-165
Range on HMM: 6-152/154.0
ITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQ---------FEYVKVPLADMPHAPIGLYFDTVADKIHSVS--RKHGATLVHCAAGVSRS
 .. |...    | |. .|| . |. |.|  | |.|    .         .||... | | ..  |   .| . . |..     ...  |||. .|||||
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

ATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
|.| |.|||.  .. | .|.  .|  |..|.|| || .||  .|..|
aallisylmdklkislslalellkdsryiikPnqGflkqleifekel

subfamily_STYXL1_pd Subfamily STYXL1 31-168 1.1e-19 64.2 In-house 16-156 (157) alignment
Range on Protein: 31-168
Range on HMM: 16-156/157.0
TSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFN--WPQ-FEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM
 . |.||  . | |... .   .   || . .  ..   ...  . ..... | ..| .   .. . . |..  ..  . ||    |.||||.. |||||
PgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylm

KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGK
  ... | .||. .|  .. ..|| .|  || ..|.||.|.
yskkitlkkaykylkkCkenvkPnrafveqlseWekqllge

0043147 (Phosphotyrosine protein) phosphatases II 32-166 1.3e-33 111.5 In-house 24-161 (172) alignment
Range on Protein: 32-166
Range on HMM: 24-161/172.0
SSLFLGRGSVASNRHLLQARGITCIVNATiE----IPNFNWPQFEYVKVPLADMPHApIGLYFDTVADKIHS--VSRKHGATLVHCAAGVSRSATLCIAY
  ....|  .|.....|. .|||.|||.| |     ...    ..|  .|  |..   .  ... . . |..  . ...|..|||| |||.|..||..||
atqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

LMKfHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
||. ... |.||...|...|| . .| ...|.| ..|..|.
lml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll

subfamily_MKPLT_pd Subfamily MKPLT 32-168 1.4e-28 93.5 In-house 27-163 (164) alignment
Range on Protein: 32-168
Range on HMM: 27-163/164.0
SSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHN
  |.||... | |...|..  || ||| . |  .     .|| .| . | ..  .. ... .|. . .     |  ||||  |.|||..  .|.|.|.. 
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

VCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGK
  | |||...| || ...|| || .||  .|. ..||
wtlkeayeylkerrsivapnrGflkqlakfeelilGk

subfamily_MKPLV_pd Subfamily MKPLV 32-168 1.4e-28 93.5 In-house 27-163 (164) alignment
Range on Protein: 32-168
Range on HMM: 27-163/164.0
SSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHN
  |.||... | |...|..  || ||| . |  .     .|| .| . | ..  .. ... .|. . .     |  ||||  |.|||..  .|.|.|.. 
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

VCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGK
  | |||...| || ...|| || .||  .|. ..||
wtlkeayeylkerrsivapnrGflkqlakfeelilGk

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 33-163 3e-30 98.7 In-house 14-145 (148) alignment
Range on Protein: 33-163
Range on HMM: 14-145/148.0
SLFLGRGSVASNRHLLQARGITCIVNATIEIPN-FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHN
 ||||    |..   |.| |.| ||||| | .| ..    ||..|.|.| |.  .  .|..... .. .  . .  |||.  |||||. | ...|..|..
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

VCLLEAYNWVKARRPVIRPNVGFWRQLIDYER
| | ||.. || .|. ..|| || .|| ..|.
vslkealalvkskrryvdpnlgfLkqLaeleq

DSPc Dual specificity phosphatase, catalytic domain 34-164 3.8e-37 122.1 Pfam-A 1-133 (133) alignment
Range on Protein: 34-164
Range on HMM: 1-133/133.0
LFLGRGSVASnRHLLQARGITCIVNATIEIPN---FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFH
|.||  | ||   ||.. ||| ..|.| |.||   .. ...||...|. |.  . |  ... . . |... .|..  ||||.||.||||||.|||||| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
|. | |||. || ||. |.||.||.|||..|||.
nlslneAyefvkerrskispnagflrqLleyerk

DSPc Dual specificity phosphatase, catalytic domain 34-164 3.8e-37 122.1 In-house 1-133 (133) alignment
Range on Protein: 34-164
Range on HMM: 1-133/133.0
LFLGRGSVASnRHLLQARGITCIVNATIEIPN---FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFH
|.||  | ||   ||.. ||| ..|.| |.||   .. ...||...|. |.  . |  ... . . |... .|..  ||||.||.||||||.|||||| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
|. | |||. || ||. |.||.||.|||..|||.
nlslneAyefvkerrskispnagflrqLleyerk

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 34-165 8.3e-21 67.6 In-house 6-141 (145) alignment
Range on Protein: 34-165
Range on HMM: 6-141/145.0
LFLGRGSVASNRHLLQARGITCIVNAT----IEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKF
|. | .  |..  .||  ||. ||| .    .   . .  ..| . .   |.    .  .|| |.| |     .    .||| |||||| |. .|.|||.
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

HNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
 |..| ||   |...|    ||| | ..|.. |.||
cnmtlseaarqvrsnrllaypnvtflknllnlekql

0040439 (Phosphotyrosine protein) phosphatases II 39-166 2.6e-30 101.3 In-house 65-246 (249) alignment
Range on Protein: 39-166
Range on HMM: 65-246/249.0
GSVASNRHLLQARGITCIVNATIEIPN-------------------------------------------FNWPQFEYVKVPLADMPHAPIGLYFDTVAD
..|......|.  |||.||..| . ..                                            . . ...  ..  |.|.  .  .|... |
etvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlld

KIHSVSR------KHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 |. |        |.| .|||| |||.|..|...||||     | ..|.|.||..... .|| . .| ...|.|......|.
fieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0051429 (Phosphotyrosine protein) phosphatases II 40-166 4.9e-22 74.3 In-house 34-225 (272) alignment
Range on Protein: 40-166
Range on HMM: 34-225/272.0
SVASNRHLlQARGITCIVNATIEI-----P-NFNWPQFEYVKVPLADMPHAPIGLYF-------------------------------------------
..|. ..| .  ||..||. . |      .  . ||...|. .|. |. . .| ...                                           
taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpd

-----DTVADKIHSVSRkHGATLVHCAAGVSRSATLCIAYLMKfHNVC--------------LLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
     ... . .. . . .|. ||||.||..|..|.. ..|.  ..|.              |.||.....|.|| .... .....| .....|.
hgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell

0040438 (Phosphotyrosine protein) phosphatases II 44-168 2.5e-25 84.9 In-house 102-277 (317) alignment
Range on Protein: 44-168
Range on HMM: 102-277/317.0
NRHLLQARGITCIVNATIEIPN---------------------------FNWPQFEYVKVPLADM----------------PHAPIGLYFDTVADKIHSV
  ....  |.|.||. | . ..                           .  . ... .... |.                |.  .  ..|.. | .. |
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

SRK----HGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFgK
 ..    .| .|||| |||.|..|...||||     | ..|.. ||.......|| . .. ...|.|.|...... |
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.k

0039614 (Phosphotyrosine protein) phosphatases II 45-166 2.4e-25 85.0 In-house 118-289 (297) alignment
Range on Protein: 45-166
Range on HMM: 118-289/297.0
RHLLQARGITCIVNATIEIPN--------------------------------------------FNWPQFEYVKVPlaDMPHAPIGLYFDTVADKIHSV
 ....  |.|.||. | ....                                            . . .| |.. |  |.   |.  ... . ......
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrea

SR---KHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 .   |.| .|||| |||.|..|...||||     | ..|..|||..... .|| .... ...|.|.|....|.
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

0043336 (Phosphotyrosine protein) phosphatases II 45-165 9e-23 76.6 In-house 105-276 (278) alignment
Range on Protein: 45-165
Range on HMM: 105-276/278.0
RHLLQARGITCIVNAT-----------------------------------------------IEIPNFNWPQFEYVKVPLADMPHaPIGLYFDTVADKI
.....  |.|.||. |                                                . . .   .. |...|  . |. .. |..| . . .
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavr

HSVSRKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
. .. ..|..|||| |||.|..|....||.     | ..|.|.||..... .|| . ..  ..|.|.......
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

0049772 (Phosphotyrosine protein) phosphatases II 46-188 8.9e-34 113.0 In-house 164-297 (314) alignment
Range on Protein: 46-188
Range on HMM: 164-297/314.0
HLLQargitcivnaTI--EIPNFNWPQFEYVKVPLADmPHAPIGLYFDTVADKIHSVsRKHGATLVHCAAGVSRSAT-LCIAYLMKFHNVCLLEAYNWVK
 ||.          ..  . . |  . ..|. .|. | ..||.  .|| . . |... .|.|..||||.||..|..| ...||||| ..|.| ||...|.
ellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr

ARRPvIRPNVGFWRQLIDYERQLFG-KSTVKMVQTPYGIVPDVYEKE
..|| |.|| ||..||..|| .|   .  .|.... |..........
lkRp.inpnpgfieqleqyefilealleylkflkkfyeyleenlldg

0045450 (Phosphotyrosine protein) phosphatases II 46-166 3.2e-27 91.5 In-house 125-304 (307) alignment
Range on Protein: 46-166
Range on HMM: 125-304/307.0
HLLQARGITCIVNATIEIPN----------------------------FNWPQFEYVKVPLADM-----------------PHAPIGLYFDTVADKIHSV
..|.  |.|.||. | ....                              .. . . .... |.                 |.  .  .|... | |. |
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

SR------KHGATLVHCAAGVSRSATLCIAYLMKFHN--------VCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 .      |.| .|||| |||.|..|...||||. .         |.||||.......|| . .| ...|.|......|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0038934 (Phosphotyrosine protein) phosphatases II 47-167 3.5e-21 71.2 In-house 51-178 (194) alignment
Range on Protein: 47-167
Range on HMM: 51-178/194.0
LLQARGITCIVNATIEIPNFNWPQF-----EYVKVPLADM---PHAPIGLYFDTVADKIHSVSrKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAY
 |. ........ | . . ..   |     ||.| |  |    |   | | |  ..|.... . ..|. .||| ||..|..||..|||.. ..  . ||.
kllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAi

NWVKARRPVIRPNVGFWRQLIDYERQLFG
.... .|| . ||......|  . ..|. 
alfrekRpgaipnqdyleallkrykelrk

subfamily_DSP23_pd Subfamily DSP23 47-147 1.4e-06 23.0 In-house 26-127 (148) alignment
Range on Protein: 47-147
Range on HMM: 26-127/148.0
LLQARGITCIVNATIEIPNF--NWPQFEYVKVPLADMpHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKAR
 |   |.  .|  | | .      |.  .|.. . |. | |     .     ..    |  |  |||. |  |. |.   ||.| ....  ||   |. .
ylldlgvrylvslteegrphveatpnltlvrlriddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RPV
|| 
rpg

0036941 (Phosphotyrosine protein) phosphatases II 49-173 5e-25 83.8 In-house 99-284 (297) alignment
Range on Protein: 49-173
Range on HMM: 99-284/297.0
QARGITCIVNATIEIPNFN------WP----------------------------------------------QFEYVKVPLADMPH-APIGLYFDTVAD
   ..|.||. | ....        ||                                              .| | . |  ..|. . . | |   ..
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KIHSVSRKHGATLVHCAAGVSRSATLCIAYLM--------KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKM
|... ....| .|||| |||.||.|...|.||        | ..|..|||..... .|| . ......|.|.... .|. | ..|.
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke

subfamily_MSG5_pd Subfamily MSG5 56-168 9.9e-21 67.6 In-house 51-163 (165) alignment
Range on Protein: 56-168
Range on HMM: 51-163/165.0
IVNATIEIPNF--NWPQFEYVKVPLADmpHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVG
..| . ||...    |  .| ..      .. | . . ...  ||.   |.   ||||  |.||||.| .||.||..|. | .||. .|..   | |..|
vinvakeindlellvpavkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsig

FWRQLIDYERQLFGK
.  ||...|  |  |
lifqlmewevalskk

0046845 (Phosphotyrosine protein) phosphatases II 65-151 8.2e-14 47.1 In-house 164-259 (284) alignment
Range on Protein: 65-151
Range on HMM: 164-259/284.0
NFNWPQFEYVKVPLADMPH-APIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFH--------NVCLLEAYNWVKARRPVIRPN
 .   .| | . |  . |. . . | |   ...... . ..| ..||| |||.|..|.....|.. .        .| .|||..... .||    .
srtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt

0051299 (Phosphotyrosine protein) phosphatases II 66-154 8.5e-15 50.4 In-house 182-274 (288) alignment
Range on Protein: 66-154
Range on HMM: 182-274/288.0
FNWPQFEYVKVPlaDMPHAP-IGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGF
..  .| | . |  |.   . . |..| . . ... . ..| ..||| |||.|..|.....|.     | . | .|||..... .|| . ...  
rtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq

0047943 (Phosphotyrosine protein) phosphatases II 68-160 1.7e-17 59.3 In-house 168-266 (273) alignment
Range on Protein: 68-160
Range on HMM: 168-266/273.0
WPQFEYVKVPLADMP-HAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLID
  .| | . |  . | .  . | |  ...|... ....| ..||| |||.|..|.....|.     | ..|..|||..... .|| . ... ..|.|..
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye

Y_phosphatase Protein-tyrosine phosphatase 69-127 1.2e-06 23.5 Pfam-A 136-193 (235) alignment
Range on Protein: 69-127
Range on HMM: 136-193/235.0
PQFEYVKVPLADMPHAPIGLYfdTVADKIHSVS-RKHGATLVHCAAGVSRSATLCIAYLM
 |. | . |  ..|  | .|    . .|... .  |.| ..||| |||.|..|.. . ..
kqlhytnWpdhgvpespksll..dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

Y_phosphatase Protein-tyrosine phosphatase 69-127 1.2e-06 23.5 In-house 136-193 (235) alignment
Range on Protein: 69-127
Range on HMM: 136-193/235.0
PQFEYVKVPLADMPHAPIGLYfdTVADKIHSVS-RKHGATLVHCAAGVSRSATLCIAYLM
 |. | . |  ..|  | .|    . .|... .  |.| ..||| |||.|..|.. . ..
kqlhytnWpdhgvpespksll..dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

subfamily_PTPRA_pd Subfamily PTPRA 69-145 8.6e-06 19.8 In-house 194-271 (330) alignment
Range on Protein: 69-145
Range on HMM: 194-271/330.0
PQFEYVKVPLADMPHAPIGLYfDTVAdKIHSVSRKH-GATLVHCAAGVSRSATLCI--AYLMKFHNVCLLEAYNWVKARR
 || .   |   .|  |||.  . .. |.... ... |.  |||.||| |. |...  | | . .   ... .. ||  |
rqfhftswPdvGvPfepiGml.kllk.kvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlr

0050432 (Phosphotyrosine protein) phosphatases II 70-152 1.7e-13 46.0 In-house 201-285 (308) alignment
Range on Protein: 70-152
Range on HMM: 201-285/308.0
QFEYVKVPlaDMPHAPIGLYFDTVADKIHSVSrKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNV
.| |   |  |.   |    . .  ......  ..| ..||| |||.|..|.....|.     | ..| ..||..... .||   ...
hfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

PTPc_DSPc_SM00012 70-127 1e-08 30.7 In-house 4-62 (105) alignment
Range on Protein: 70-127
Range on HMM: 4-62/105.0
QFEYVKVPLADMPH--APIGLYFDTVADKIHSVSRkHGATLVHCAAGVSRSATLCIAYLM
...| . |   .|.   .|  ... | .. .  .. .. ..||| |||.|..|.. ....
hyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldil

subfamily_PTPN1_pd Subfamily PTPN1 70-124 2.7e-07 24.6 In-house 166-221 (290) alignment
Range on Protein: 70-124
Range on HMM: 166-221/290.0
QFEYVKVPLADMPHAPIG-LYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIA
.| |.. |   .|..|   | |     .  |.|...| ...||.||. || |.|..
hfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

subfamily_PTPDC1_pd Subfamily PTPDC1 70-146 1.1e-06 23.2 In-house 82-156 (182) alignment
Range on Protein: 70-146
Range on HMM: 82-156/182.0
QFEYVKVPLADMPHAPIGLYFDTVadKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRP
.  . .....|   |..   .| |  |. . . ..|.. ||| ||  |   |  .||.  ...   .| . |...||
giyvynfgwkDygvasleriLdiv..kvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp

subfamily_PTPN6_pd Subfamily PTPN6 70-123 1.8e-06 22.2 In-house 190-246 (306) alignment
Range on Protein: 70-123
Range on HMM: 190-246/306.0
QFEYVKVPLADMPHAPIGL--YFDTVADKIHSVS-RKHGATLVHCAAGVSRSATLCI
|... . | ...|. |  .  ....|  | .... ...|...|||.||. |  |. .
qyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

subfamily_PTPRD_pd Subfamily PTPRD 70-142 9.8e-06 19.5 In-house 181-254 (564) alignment
Range on Protein: 70-142
Range on HMM: 181-254/564.0
QFEYVKVPLADMPHAPIGLyFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY--LMKFHNVCLLEAYNWVK
|| ... |  ..|. . .|  | . .  .. ....| ..||| ||| |. | ..    | . ..  ... |. ||
qFhFtsWPdhgvpesatsl.LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvk

subfamily_PTPMT1_pd Subfamily PTPMT1 71-166 1.6e-14 48.7 In-house 74-169 (171) alignment
Range on Protein: 71-166
Range on HMM: 74-169/171.0
FEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 |.....  |. .||         . |..|  |     ||| || .||||| ..|||| ... . || . .|..|. || .   |..|  ||..| 
veqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll

subfamily_Laforin_pd Subfamily Laforin 73-148 4.1e-06 19.8 In-house 79-154 (183) alignment
Range on Protein: 73-148
Range on HMM: 79-154/183.0
YVKVPLADMPHA-PIGLYFDTVaDKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVI
|. .|. |.     .    ..|   .|..  |     ||| ||| ||...   .|.   .  |      . |.|||.
yiwlptedlstesrvenlpqav.yllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv

0048567 (Phosphotyrosine protein) phosphatases II 89-162 2.4e-10 35.0 In-house 59-135 (157) alignment
Range on Protein: 89-162
Range on HMM: 59-135/157.0
YFDTVADKIHSVSRKHGATLVHCAAGV---SRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYE
..  . ....... ...|  ||| ||    .|.|||. .||.. ..    ||.....  || . |    .  | .|.
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn

DSPc_SM00195 94-127 3.7e-06 21.8 In-house 185-218 (263) alignment
Range on Protein: 94-127
Range on HMM: 185-218/263.0
ADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM
    .| |...| ..||| |||.|..|.. . ..
ravkkskstssgpivVhCsaGvgRtgtfvtidii

PTPc_SM00194 94-127 3.7e-06 21.8 In-house 185-218 (263) alignment
Range on Protein: 94-127
Range on HMM: 185-218/263.0
ADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM
    .| |...| ..||| |||.|..|.. . ..
ravkkskstssgpivVhCsaGvgRtgtfvtidii

subfamily_CDC14_pd Subfamily CDC14 99-146 2.5e-08 28.2 In-house 258-305 (328) alignment
Range on Protein: 99-146
Range on HMM: 258-305/328.0
SVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRP
 . . .||  ||| ||. |  ||  .|||| ...   ||  |..  ||
iaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP