Gene DUSP21 in Homo sapiens

Synonym: LMWDSP21, DUSP21

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP018_AA protein Get Run
HsapP018_AA_19-164 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045098 (Phosphotyrosine protein) phosphatases II 4-163 1.9e-32 108.2 In-house 4-274 (278) alignment 
Range on Protein: 4-163
Range on HMM: 4-274/278.0
SASSFSSSQGVQQPSIYSFSQITRSLFLSNGV-----------------------------------------AANDKLLLSSNRITAIVNAS-------
 ||. ..... .... ...|.|| .|.|.|.                                          .|..  .| ...||.||..        
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

---------------------------------------------VEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDM-------------
                                              .  . ... ..|. .|  .. .. ....|. . . |.                 
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

-RQGRTLLHCMAGVSRSASLCLAYLMKYH---SMSLLDAHTWTKSRRPI-IRPNNGFWEQLINYEFKLFNN
 ..|..| ||.|||.|.. |..||||...    ..||.| .. .|.||. . .| .....|. .. .|...
dsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0044763 (Phosphotyrosine protein) phosphatases II 11-165 5e-38 125.8 In-house 12-175 (178) alignment 
Range on Protein: 11-165
Range on HMM: 12-175/178.0
SQGVQQPSIYSFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEG---------IQYIKVPVTDARDSRLYDFFDPIADLIHTID-MRQG
 .|..    . .|.|.  |.|..  .|.|. ||  . ||.||| . |. . |..          |||...|. |  .  |...|. . ..|...   ..|
leglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekgg

RTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPiIRPNNGFWEQLINYEFKLFNNNT
..| ||.|||.||..|..|||||....|| .|  . ..||| | || |...||. .| .|.....
pvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
PTEN_1 16-163 8.6e-28 92.5 In-house 42-194 (196) alignment 
Range on Protein: 16-163
Range on HMM: 42-194/196.0
QpsiysfsQITRSLFLSNGVAA-NDKLLLSSNRITAIVNASVEVVN---------VFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDM--RQGRTL
|       .|  .|.. .   . .|.  | .. ||..|| | |  .          | .|..|...|..|   . |  .|| ....|. .    ...  |
q.......eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

LHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNN
 || ||..||. .. ||||... ..  .|  . ...|| ..||....|.|..|. .|...
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_DSP14_pd Subfamily DSP14 17-172 3.7e-72 235.4 In-house 2-156 (157) alignment 
Range on Protein: 17-172
Range on HMM: 2-156/157.0
PSIYSFSQITRSLFLSnGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASL
|.....||||.||||| ||||..| ||....||.|.|..||..|  ...|...||||.|.....|...||..|| |.......|.||.||.|||||||||
pelaalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAsl

CLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNNNTVRMINSP
||||||||...|| .|....||.|||||||.|||.|||.|| ||.....|.|..||
claylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvdsp
subfamily_DSP1_pd Subfamily DSP1 18-162 1.8e-41 135.9 In-house 13-158 (163) alignment 
Range on Protein: 18-162
Range on HMM: 13-158/163.0
SIYSF-SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASL
..|    .|.  |.|     | .. .|.|..||||.|.| |. ||| .  .| |... | ..  ..  |... . |...   .|. |.|| ||.|||..|
klydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

CLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFN
||||||| . .|| .|....|.||.||.|| ||  ||.||| || .
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_MKPLT_pd Subfamily MKPLT 18-158 1.1e-28 93.8 In-house 18-158 (164) alignment 
Range on Protein: 18-158
Range on HMM: 18-158/164.0
SIYSFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLC
 ||    .   |.| |.  |... .|    || ||| | |  . | . ..| .| | |  |..| .|.. .|...       || |.||  |.|||.|  
kiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

LAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
.|.|.|..   | .|. . | || |..|| ||  || ..| 
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 18-158 1.1e-28 93.8 In-house 18-158 (164) alignment 
Range on Protein: 18-158
Range on HMM: 18-158/164.0
SIYSFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLC
 ||    .   |.| |.  |... .|    || ||| | |  . | . ..| .| | |  |..| .|.. .|...       || |.||  |.|||.|  
kiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

LAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
.|.|.|..   | .|. . | || |..|| ||  || ..| 
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
0051082 (Phosphotyrosine protein) phosphatases II 18-156 4.9e-25 83.3 In-house 4-149 (151) alignment 
Range on Protein: 18-156
Range on HMM: 4-149/151.0
SIYSFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEV-----VN-VFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMR-QGRTLLHCMAGV
... ||..|  |..|.|  | .  || .. |..|||   |.      . .  .||... .|..|  |  | ..|| ...... ..   .| .| ||.||.
dyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGk

SRSASLCLAYLMKyHSMSLLDAHTWTKSRRP-IIRPNNGFWEQLINY
.|.. |...|||. . .|| .|  . ...|| ...||..|. ||. .
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0048076 (Phosphotyrosine protein) phosphatases II 20-161 9.8e-34 111.4 In-house 2-143 (145) alignment 
Range on Protein: 20-161
Range on HMM: 2-143/145.0
YSFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLA
| .|.|. .|.|..  .|.|  || .. ||...| . |  ... .||||. .|. |     |..... . ..|...  . |..| ||.|||.|...|..|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLF
|||.....|| .|  . .|.||.. || |....|. .| .|.
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
0046846 (Phosphotyrosine protein) phosphatases II 20-163 8.3e-26 86.2 In-house 10-175 (176) alignment 
Range on Protein: 20-163
Range on HMM: 10-175/176.0
YSFSQITRSLFLSNGV----------AANDKLLLSSNRITAIVNASVEV-------VNVF----FEGIQYIKVPVTDARDSRLyDFFDPIADLIHTIDMR
.....|. .|.|..             |..  .| ...|||.||   ||        | .     .||||. .|. |     | . .. . ..|..   .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

QGRTLLHCMAGVSRSASLCLAYLMKY-HSMSLLDAHTWTKSRRP-IIRPNNGFWEQLINYEFKLFNN
 |..| ||.||..|.. |..|||... . .|...|  . ...||  . .. .....|  .| .|...
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllkk
0036282 (Phosphotyrosine protein) phosphatases II 20-160 1.1e-24 82.5 In-house 10-169 (174) alignment 
Range on Protein: 20-160
Range on HMM: 10-169/174.0
YSFSQITRSLFLSNGVAAnDKLLLSSNRITAIVNASVEVVNV---------------FFEGIQYIKVPVTDARDSRLYDfFDPIADLIHTIDMR--QGRT
 ..| ||. |....| .| .  .| ...||..|.   |. .                  .||||...|. |     |   .. . ......  .  .| .
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

LLHCMAGVSRSASLCLAYLMKYHSM-SLLDAHTWTKSRR---PIIRPNNGFWEQLINYEFKL
| ||.|||.|.. |..||||... . || ||  . ...|   | . .. .....|  .| .|
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_DSP10_pd Subfamily DSP10 21-165 1.7e-37 122.7 In-house 13-158 (159) alignment 
Range on Protein: 21-165
Range on HMM: 13-158/159.0
SFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFE-GIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLA
  ||.   ||| ... |.|. .|   .|||..|   .| | | | ...| ..||.|.    |   |.   . |. .  .. | |.||.||.||||.. .|
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNNNT
||||. ..|| ||. . |..|||| || .|  ||...| .| ....
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska
0048179 (Phosphotyrosine protein) phosphatases II 21-158 4e-32 106.3 In-house 3-142 (144) alignment 
Range on Protein: 21-158
Range on HMM: 3-142/144.0
SFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFE--GIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCL
 .|.|. .|.|..  .|.|  || .. ||...| . |  . |.|  ||||...|. |     |..... . ..|...  . |..| ||.|||.|...|..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
|||||.. .|| .|  . .||||.. || |....|..|| 
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP3_pd Subfamily DSP3 21-162 2.9e-30 99.0 In-house 10-159 (162) alignment 
Range on Protein: 21-162
Range on HMM: 10-159/162.0
SFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVE-V-----VNVFFE--GIQYIKVPVTDARDSRLYDFFDPIADLIH-TIDMRQGRTLLHCMAGVS
.. ... .|....  .|.||  |    || ..||.   .      . |..  .|.|. ..|.|.  . |  .|.. |. |. ... ..|. |.||..|||
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSASLCLAYLMKYHSMSLLDAHTWTKSRRPIiRPNNGFWEQLINYEFKLFN
||| | ||||| ...|.| .| .  ...| | .||.|| .||.... .| .
RsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelkr
0037934 (Phosphotyrosine protein) phosphatases II 21-161 4.5e-29 97.1 In-house 38-242 (243) alignment 
Range on Protein: 21-161
Range on HMM: 38-242/243.0
SFSQITRSLFLSNG--------VAANDKLLLSSNRITAIVNASVEV---------------------------------------------VNVFFEGIQ
.....|. |....|        ..|..  .| ...||.||.   .|                                              ......|.
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

YIKVPVTD----ARDSRLYDFFDPIADLIHT-----IDMRQGRTLLHCMAGVSRSASLCLAYLMKYH-SMSLLDAHTWTKSRRPI-IRPNNGFWEQLINY
|  .|. |       . |.||.| . . |.       . ..|..|.||.|||.|.. |..||||... ...|..|  . ...||  . .. .....|. .
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

EFKLF
. .|.
llell
subfamily_DSP19_pd Subfamily DSP19 22-160 1.6e-37 123.2 In-house 12-150 (152) alignment 
Range on Protein: 22-160
Range on HMM: 12-150/152.0
FSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYL
 .... .|.|.   .|.||  |....|| |.| ...|.||| . ..| .... |  . .| .... . | |.     .|. |.|| ||||||||. .|||
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
|| ...|| .| .  .. || |.||.||..|| .|| .|
mkkeelsleealelvrearpcikPneGFikqLkeyeael
PTPc_motif_SM00404 22-158 3.6e-37 122.4 In-house 2-139 (140) alignment 
Range on Protein: 22-158
Range on HMM: 2-139/140.0
FSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVN-VFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAY
 |.|.. |.|..  .|... ||....||...|.. ||..    .|.|....|. | . . | ...| ..| |...  ..|. | ||.|||||||.|..||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
||.|...|| .|    |.|||||.|| .|..|||.|| 
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0041856 (Phosphotyrosine protein) phosphatases II 22-166 6.2e-33 109.3 In-house 19-178 (182) alignment 
Range on Protein: 22-166
Range on HMM: 19-178/182.0
FSQITRSLFLSNGVA--------------ANDKLLLSSNRITAIVNASvEVV----NVFFEGIQYIKVPVTDARDSRlydfFDPIADLIHTIDMRQGRTL
...|. .|.|..  |              |..  .| ...||.|||.. |.     ..  .||||...|. |         .| . |.|...  ..|..|
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

LHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRP--IIRPNNGFWEQLINYEFKLFNNNTV
 ||.|||.|...|..|||||....|| .|  . .||||  .|.|| .|..||. .|..|......
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Slingshot_pd Subfamily Slingshot 22-160 2.5e-32 105.6 In-house 19-157 (169) alignment 
Range on Protein: 22-160
Range on HMM: 19-157/169.0
FSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYL
 |.|   ..|     | .   |..|... |.| . |. | | | ..|... | |  .. |.....   . |..   .. . |.||  |||||||  .|| 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
|| ...|| .|... |.|| .|.||.||..|| .||  |
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_DSP8_pd Subfamily DSP8 22-163 3.5e-32 105.2 In-house 15-157 (159) alignment 
Range on Protein: 22-163
Range on HMM: 15-157/159.0
FSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVN-VFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAY
  .|.. |.|   . . .. ||| . |. ..||| . ..  ...  ....||| |  | .| ..||   . |  .   .|| |.|..|| ||||.. .||
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNN
.||. .||| .|... |..|| | ||  | .||..|| .| ..
imktlemsldeayrfvkekrptispnlnflgqLleyekelkll
subfamily_DSP15_pd Subfamily DSP15 22-163 4.1e-31 102.1 In-house 2-142 (151) alignment 
Range on Protein: 22-163
Range on HMM: 2-142/151.0
FSQITRSLFLSNGVAANDKLLLSSNRITAIVNASvEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYL
 |.. . |.|.|   ..|. ||. ..|| |.. . .  . ... |.|  ....|. .  |  ||.   ..||.  ....  |.||.||||||. |. |||
iskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNN
|   ...  || .  | .| .  || || .|| .|| .  ..
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_DSP6_pd Subfamily DSP6 22-160 9.9e-30 97.1 In-house 14-154 (158) alignment 
Range on Protein: 22-160
Range on HMM: 14-154/158.0
FSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFE--GIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLA
  .|.  |.| .  .|..  .|.  .|  ..|   .. |.| |   ..| ..|..|     |  ||    ..|     ..   |.||.||.|||  ..||
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
||||.. .|| ||. . |.|.. | ||  | .||...| .|
ylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0042113 (Phosphotyrosine protein) phosphatases II 22-162 1.2e-23 79.2 In-house 47-244 (245) alignment 
Range on Protein: 22-162
Range on HMM: 47-244/245.0
FSQITRSLFLSNGVAANDKL----LLSSNRITAIVNASVEV----------------------------------------------VNVFFEGIQYIKV
...||. .....| ....      .| ...||.||. . |.                                               .  .|.|.|  .
gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

PVTDARDSRLYDFFDPIADLIHTIDM--RQGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFN
|. |     | . .. . ......    ..|..| ||.|||.|.. ...||||     |.. .|| .|  . .|.|| .... .....|. ....|..
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_LRR-DSP_pd Subfamily LRR-DSP 23-164 1.8e-28 93.4 In-house 121-262 (263) alignment 
Range on Protein: 23-164
Range on HMM: 121-262/263.0
SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKV-PVTDARDSRLYDFFDPIADLIHTiDMRQGRTLLHCMAGVSRSASLCLAYL
..|   |||    .||.| .| .. .| |. |  ..  .| .  .|. .  . |. .  .. .|. .  .|.    ..|  |.|| ||||||..| ..||
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafiee.GrkkGGvlvhcraGvsrsstlvisyl

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNNN
||.... . .|   ....|| |.||.|| .||  || |||  |
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfctn
subfamily_DSP12_pd Subfamily DSP12 23-158 2.5e-27 90.2 In-house 3-141 (155) alignment 
Range on Protein: 23-158
Range on HMM: 3-141/155.0
SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIK---VPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLA
|.|.  |.|..  |.... ||..  ||...    | .. . . .....   ....|  .  . ...| . | |.    ..|  | ||.||||||.....|
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
||||.. .|| .|.   |. .| |.||.|| |||  .| 
YlmkkeklslekAlklvkekkpeiepNegFleQLklfek
0049260 (Phosphotyrosine protein) phosphatases II 23-157 5.9e-26 86.4 In-house 9-146 (152) alignment 
Range on Protein: 23-157
Range on HMM: 9-146/152.0
SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVN---VFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHT-IDMRQGRTLLHCMAGVSRSASLCL
 ...  ... .  .|... .| .. ||.||.   .. .    . ..|||. .|. |     | .... . ..|.  .  ..|..| ||.|||.|.. |..
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYLMKyHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
||||. . .||..|  . ...||.. || |....| ..|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefe
subfamily_STYXL1_pd Subfamily STYXL1 24-162 8.2e-18 58.1 In-house 14-155 (157) alignment 
Range on Protein: 24-162
Range on HMM: 14-155/157.0
QITRSLFLSNGVAANDKLLLSSNRITAIVNASVE---VVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAY
 .   |.| |   | .. .    .. | || | .   ...   .  . ....| |  .. | .... . ..|..   ..   |.    |.||||.. .||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

LMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFN
|| .. ..| .|..  |  .. ..|| .| ||| ..| .|..
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
0043147 (Phosphotyrosine protein) phosphatases II 25-161 1.7e-28 94.9 In-house 22-161 (172) alignment 
Range on Protein: 25-161
Range on HMM: 22-161/172.0
ITRSLFLSNGVAANDKLLLSSNRITAIVNASvE----VVNVFFEGIQYIKVPVTDARDSrLYDFFDPIADLIHT--IDMRQGRTLLHCMAGVSRSASLCL
.   ... .   | .  .| .. ||.|||.  |      ... .||||. .|. |     | .... . ..|..  .  ..|..| ||.|||.|.. |..
fiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva

AYLMKyHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLF
||||. ...||..|  . ...||.. .| ... .|  .| .|.
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 26-160 4e-24 78.7 In-house 7-152 (154) alignment 
Range on Protein: 26-160
Range on HMM: 7-152/154.0
TRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEG---------IQYIKVPVTDARDSRLYDFFDPIADLIHT-I-DMRQGRTLLHCMAGVSRSA
.  |..|   || .||.|  ..|. |.| .. . |.| .          |.|... . |  .  . . .|   ..|.  |  ..... |.|. .||||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

SLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
.| ..|||.  ..||  |    |. |.||.||.|| .||  .| .|
allisylmdklkislslalellkdsryiikPnqGflkqleifekel
0051429 (Phosphotyrosine protein) phosphatases II 26-163 5.5e-19 64.3 In-house 20-227 (272) alignment 
Range on Protein: 26-163
Range on HMM: 20-227/272.0
T-RSLFLSNGV---AANDKLLLSSNRITAIVNASVEVV------NVFFEGIQYIKVPVTDARDSRLYDFF------------------------------
  . |..|.|     |.|   | ...|..||.   |.         . .||.|. .|. |  . .   ..                              
kpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

------------------DPIADLIHTIDMrQGRTLLHCMAGVSRSASLCLAYLMKyHSMS--------------LLDAHTWTKSRRPIIRPNNGFWEQL
                  ... .|.. .   .|. | ||.||..|.. .....|.  . .|              |..|  . ...|| .... .....|
revmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl

INYEFKLFNN
 ... .|...
yeallellrs
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 28-157 5.6e-28 91.3 In-house 14-144 (148) alignment 
Range on Protein: 28-157
Range on HMM: 14-144/148.0
SLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFF-EGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHS
 ||| .   | |   |    .|.||||. |  |..   ||.|..|.. |  .  |  .|..|.. ..    . .| |.|.  |||||. | |..|.... 
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

MSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
.|| .|    ||.|. ..||.|| .|| ..|
vslkealalvkskrryvdpnlgfLkqLaele
DSPc Dual specificity phosphatase, catalytic domain 29-158 1.6e-33 110.4 Pfam-A 1-132 (133) alignment 
Range on Protein: 29-158
Range on HMM: 1-132/133.0
LFLSNGVAANdKLLLSSNRITAIVNASVEVVNVFF---EGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYH
|.|..  .|. . ||. . ||...|.. || | ..   . |.|...|| | ... . .... . . |.... .... | ||.||.||||.|..|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
..|| .|    |.||..|.|| ||. ||..|| 
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 29-158 1.6e-33 110.4 In-house 1-132 (133) alignment 
Range on Protein: 29-158
Range on HMM: 1-132/133.0
LFLSNGVAANdKLLLSSNRITAIVNASVEVVNVFF---EGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYH
|.|..  .|. . ||. . ||...|.. || | ..   . |.|...|| | ... . .... . . |.... .... | ||.||.||||.|..|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

SMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
..|| .|    |.||..|.|| ||. ||..|| 
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 29-160 1.4e-18 60.4 In-house 6-141 (145) alignment 
Range on Protein: 29-160
Range on HMM: 6-141/145.0
LFLSNGVAANDKLLLSSNRITAIVNAS----VEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKY
|.   .. |||  .|    |. ||| .    |   ..  | |. . .   | .   | . || ..|.|          ..||||||||| .. .|.||||
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

HSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
 .|.| .|    .|.|    ||  |  .|.| | .|
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0040439 (Phosphotyrosine protein) phosphatases II 36-163 8.1e-26 86.6 In-house 67-248 (249) alignment 
Range on Protein: 36-163
Range on HMM: 67-248/249.0
AANDKLLLSSNRITAIVNASVEVVN-------------------------------------------VFFEGIQYIKVPVTDARDSRLYDFFDPIADLI
 ...  .|  ..||.||... .| .                                            . | ...  ...||  |  . ..|... |.|
vedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfi

HTIDM------RQGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNN
. ..       ..|..| ||.|||.|.. ...||||     |.. ..|..|  . .|.|| . .| .....|......|...
eavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0045450 (Phosphotyrosine protein) phosphatases II 43-163 2.7e-24 81.9 In-house 127-306 (307) alignment 
Range on Protein: 43-163
Range on HMM: 127-306/307.0
LSSNRITAIVNASVEVVN-----------------------------VfFEGIQYIKVPVTDA-----------------RDSRLYDFFDPIADLIHTID
|  ...|.||. . .| .                             .  .|... ...|||                   |  . ..|... |.|. ..
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

M------RQGRTLLHCMAGVSRSASLCLAYLMKYHS--------MSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNN
       ..|..| ||.|||.|......||||...         ..||.|  . ...|| . .| .....|......|...
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
subfamily_STYX_pd Subfamily STYX 43-168 2.4e-18 59.8 In-house 35-165 (166) alignment 
Range on Protein: 43-168
Range on HMM: 35-165/166.0
LSSNRITAIVN----ASVEVV-NVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTK
| .. || ||        ...   | . ..|. . |.|.    .  ..  . ..| .   . |. |.|  ||.||||.| .||.|. . .   .|... .
lkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvq

SRRPIIRPNNGFWEQLINYEFKLFNNNTVRM
 ||  | ||.|| .|| .||   . . |...
errfcinpnegfvsqlkeyeaiylakltikl
0040438 (Phosphotyrosine protein) phosphatases II 45-166 3.1e-22 74.7 In-house 108-281 (317) alignment 
Range on Protein: 45-166
Range on HMM: 108-281/317.0
SNRITAIVNASVEVVN----------------------------VfFEGIQYIKVPVTDA----------------RDSRLYDFFDPIADLIHTIDMR--
 ...| ||.   .. .                            .  .||.. ...|.|                  |  . . .|.. |... ..    
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

--QGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNNNTV
  .| .| ||.|||.|......||||     |.. ... .|  . ...|| . .. .....|. ......... .
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0039614 (Phosphotyrosine protein) phosphatases II 47-163 4.4e-20 67.8 In-house 125-291 (297) alignment 
Range on Protein: 47-163
Range on HMM: 125-291/297.0
RITAIVNASVEVVN--------------------------------------------VFFEGIQYIKVPvtdarDSRLYDFFDPIADLIHTIDM-----
..|.||.   .| .                                             .   .||.. |     |    . .. . .... ..      
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.....dhgvppslellleflelvrealael

-RQGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNN
 ..|..| ||.|||.|......||||     |.. ...|.|  . ...|| .... .....|......|...
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0036941 (Phosphotyrosine protein) phosphatases II 48-171 1e-22 76.3 In-house 103-287 (297) alignment 
Range on Protein: 48-171
Range on HMM: 103-287/297.0
ITAIVNASVEVVNVFFEG----------------------------------------------------IQYIKVPvtdarDSRLYDFFDPIADLIHTI
.| ||. . .| . .                                                       ..|.. |     |  . . .... |.|. .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.....dhgvpespaslldfielv

DM------RQGRTLLHCMAGVSRSASLCLAYLM--------KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNNNTVRMINS
.       ..|..| ||.|||.||.....|.||        |.. ...|.|  . ...|| . .. .....|. ....|........  .
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
0049772 (Phosphotyrosine protein) phosphatases II 61-188 1.6e-30 102.4 In-house 174-302 (314) alignment 
Range on Protein: 61-188
Range on HMM: 174-302/314.0
VFFE--GIQYIKVPVTDaRDSRLYDFFDPIADLIHTIdMRQGRTLLHCMAGVSRSAS-LCLAYLMKYHSMSLLDAHTWTKSRRPiIRPNNGFWEQLINYE
 .||  ||.|. .||.|  .  | ..|| . ..|..   ..|..| ||.||..|... ...|||||.. .|| .|  . ...|| |.|| ||.|||..||
elferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqye

FKL-FNNNTVRMINSPVGNIPDIYEKDLRMMI
|.| . .. .... .  . ........|...|
filealleylkflkkfyeyleenlldglqlli
0043336 (Phosphotyrosine protein) phosphatases II 61-159 5.9e-17 57.5 In-house 173-275 (278) alignment 
Range on Protein: 61-159
Range on HMM: 173-275/278.0
VFFEGIQYIKVPVTDARDsRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLIN
 .  ...|...|  .. .  | ...| . .... .. ..| .| ||.|||.|.. ....||.     |.. ..|..|  . ...|| . ..  ....|..
rtvthyhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye

YEFK
... 
alle
subfamily_MSG5_pd Subfamily MSG5 62-163 2.9e-19 62.8 In-house 64-163 (165) alignment 
Range on Protein: 62-163
Range on HMM: 64-163/165.0
FFEGIQYIKVPVTdaRDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLF
    ..| ..  .   ||..   .  .. .||.   .. . |.||  |.|||||| .||.|||...|| ||.   ||.   | |. |.  ||...|  | 
lvpavkyyhiewe..hdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevals

NN
..
kk
0038934 (Phosphotyrosine protein) phosphatases II 64-162 9.7e-19 63.2 In-house 78-178 (194) alignment 
Range on Protein: 64-162
Range on HMM: 78-178/194.0
EGIQYIKVPVTDARDSRLYDFFDPIADLIHTID--MRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLF
 ||.|.| |. |   .  ..  . . ||....     .|  . ||.||..|.. |. |||.... ||. .|  . ...|| . || ...|.|  .   |.
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr

N
.
k
subfamily_PTPMT1_pd Subfamily PTPMT1 64-160 4.6e-14 47.2 In-house 72-168 (171) alignment 
Range on Protein: 64-160
Range on HMM: 72-168/171.0
EGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
.|.........|  ..   .      ..|. .  .. |  .|| || .|||.|  .|||| . .|. .|..  |..|.||| ..  |..| .|| ||
lgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_Laforin_pd Subfamily Laforin 64-143 1.5e-07 24.5 In-house 75-154 (183) alignment 
Range on Protein: 64-143
Range on HMM: 75-154/183.0
EGIQYIKVPVTDA-RDSRLYDFFDPIaDLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPII
||. || .|. |   .||.  . . .  |.|..  .  .  .|| ||| ||...   .|.     ||        ..||..
eglayiwlptedlstesrvenlpqav.yllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
0046845 (Phosphotyrosine protein) phosphatases II 66-143 4.9e-11 38.0 In-house 170-256 (284) alignment 
Range on Protein: 66-143
Range on HMM: 170-256/284.0
IQYIKVPvtdarDSRLYDFFDPIADLIHTIDMR------QGRTLLHCMAGVSRSASLCLAYLMKYH--------SMSLLDAHTWTKSRRPII
..|.. |     |    . .... .......        .| .. ||.|||.|.. .....|....         ...|.|  . ...||  
fhytswp.....dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
PTPc_DSPc_SM00012 69-125 9.4e-07 24.4 In-house 13-65 (105) alignment 
Range on Protein: 69-125
Range on HMM: 13-65/105.0
IKVPVTDardsrlydffDPIADLIHTIDMR------QGRTLLHCMAGVSRSASLCLAYLMKYH
 .|| .           |.| .|.. ..        .. ...|| |||.|.. .......  .
hgvPees..........dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0051299 (Phosphotyrosine protein) phosphatases II 73-146 4.4e-12 41.5 In-house 189-271 (288) alignment 
Range on Protein: 73-146
Range on HMM: 189-271/288.0
VTDARDSRLYDFFDPIADLIHTIDMR----QGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPN
.|.  |    | .... |... ..      .| .. ||.|||.|.. .....|.     | . ...|.|  . ...|| . ..
ytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0047943 (Phosphotyrosine protein) phosphatases II 76-155 5.6e-14 47.7 In-house 176-266 (273) alignment 
Range on Protein: 76-155
Range on HMM: 176-266/273.0
ARDSRLYDFFDPIADLIHTIDM------RQGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLIN
  |    . .... ..|. ..       ..| .. ||.|||.|........|.     |.. ...|.|  . .|.|| . ..  ....|..
wpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0048567 (Phosphotyrosine protein) phosphatases II 77-157 1.7e-10 35.5 In-house 52-135 (157) alignment 
Range on Protein: 77-157
Range on HMM: 52-135/157.0
RDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGV---SRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
  ..||.|.  . .... .... ..  .|| ||    .|.| |. .||.......  .|  . .  || . |    .  | .|.
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
0050432 (Phosphotyrosine protein) phosphatases II 80-146 5.3e-11 37.9 In-house 211-284 (308) alignment 
Range on Protein: 80-146
Range on HMM: 211-284/308.0
RLYDFFDPIADLIHTIDMR--QGRTLLHCMAGVSRSASLCLAYLM-----KYHSMSLLDAHTWTKSRRPIIRPN
   . .... |... .. .  .| .. ||.|||.|.. .....|.     | . .....|  . ...||   ..
gvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
subfamily_CDC14_pd Subfamily CDC14 91-141 1.1e-06 22.8 In-house 255-305 (328) alignment 
Range on Protein: 91-141
Range on HMM: 255-305/328.0
LIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRP
... ..  .|   .|| ||. |  .|  .|||| . ..  .| .| .  ||
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP