Gene DUSP15 in Homo sapiens

Synonym: VHY, RP11-243J16.11-006, DUSP15

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP020_AA protein Get Run
HsapP020_AA_2-146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 3-138 8.2e-40 131.7 In-house 21-166 (178) alignment 
Range on Protein: 3-138
Range on HMM: 21-166/178.0
NGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHES--------PQPLLQD--ITYLRIPVADTPEVPIKKHFKECINFIHCCR-LNGGNCLVHCFAG
......|||||||.. .|.||..| ...||||... |         ..  ...  |.||.||. | .. .. .|| |...||. ..  .||..|||| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

ISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPiANPNPGFRQQLEEF
..||.|.| || | . || . ...| ... || ..||||...||.||
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyef
0048179 (Phosphotyrosine protein) phosphatases II 3-138 2.8e-37 122.9 In-house 2-140 (144) alignment 
Range on Protein: 3-138
Range on HMM: 2-140/144.0
NGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHE---SPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIV
. ....|||||||.. .|.||..| ...||..|.. |    . .  . |.||..|. | .  .. ... |...||. .. .||..|||| ||..|..|.|
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

TAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
.||.| . || . ..|. ... ||.|.||||....|.|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLley
0046846 (Phosphotyrosine protein) phosphatases II 3-138 9.6e-31 102.3 In-house 10-168 (176) alignment 
Range on Protein: 3-138
Range on HMM: 10-168/176.0
NGMTKVLPGLYLGNFI----------DAKDLDQLGRNKITHIISIHES------------PQPLLQDITYLRIPVADTPEVPIkKHFKECINFIHCCRLN
.... ....|.||..            |..|..| ...||..... |             |.    .|.||..|. |    .. ... |...||. .. .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GGNCLVHCFAGISRSTTIVTAYVMTV-TGLGWRDVLEAIKATRP-IANPNPGFRQQLEEF
||. ||||.|||.|. |.| || .    || . ..|. ... ||  | ..|.....|.||
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_DSP15_pd Subfamily DSP15 4-154 1e-71 233.9 In-house 1-151 (151) alignment 
Range on Protein: 4-154
Range on HMM: 1-151/151.0
GMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYV
|..|||||||||||.|.|| ..|....||||.|.|.....||.||.|. |...|||.. ..|.|||...|||.|||...|.||||.||.|||.|.|.||.
giskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKLRRQLEERF
|||| |.|||.||.|||.| .|||| ||..||.|. .......|.||.|.|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlkeef
0048076 (Phosphotyrosine protein) phosphatases II 4-138 1.5e-37 123.8 In-house 3-138 (145) alignment 
Range on Protein: 4-138
Range on HMM: 3-138/145.0
GMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISI-HESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY
.....|||||||.. .|.||..| ...||..... .| . .  ..|.||..|. | .. .. ... |...||. .. .||..|||| ||..|..|.| ||
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
.|   |. . ..|| ... ||.|.||||....|.||
lmlllgvsleealelvrsqrpgavpnpgqlrflyef
subfamily_DSP14_pd Subfamily DSP14 4-139 1.6e-36 119.6 In-house 6-141 (157) alignment 
Range on Protein: 4-139
Range on HMM: 6-141/157.0
GMTKVLPGLYLGnFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY
..... | |.|.    |.. ..| ..|||.|| .  | |.. |.|| ....||.|.||. . ||| | .. |.  . .||..|||| ||.||| ....||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFG
.|    |  |.  ...|..||| .|| || .|| .. 
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyE
subfamily_DSP10_pd Subfamily DSP10 4-139 6.2e-36 117.7 In-house 13-150 (159) alignment 
Range on Protein: 4-139
Range on HMM: 13-150/159.0
GMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQ-DITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTA
 ...||| |.||.  ||.||| | | .||... .  ..|.   . ...| |||| || .  .|..|.| ..||.  | .| . |||| ||||||.|.| |
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFG
|.|. ..|  .|  . .| .|||  || .|  || || 
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefe
0041856 (Phosphotyrosine protein) phosphatases II 4-141 1.5e-32 108.0 In-house 18-171 (182) alignment 
Range on Protein: 4-141
Range on HMM: 18-171/182.0
GMTKVLPGLYLGNFID--------------AKDLDQLGRNKITHIISIHESP----QPLLQDITYLRIPVADTPEVPikkhFKECINFIHCCRLNGGNCL
........||||.. .              |..|..| ...||.|... | .        . |.||..|. | .  .    . |...||. .. .||..|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRP--IANPNPGFRQQLEEFGWA
||| ||..|. |.| ||.| . |........ ..  ||  . .|| .|  || .. . 
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0036282 (Phosphotyrosine protein) phosphatases II 4-139 3.7e-27 90.5 In-house 11-166 (174) alignment 
Range on Protein: 4-139
Range on HMM: 11-166/174.0
GMTKVLPGLYLGNFIDAkDLDQLGRNKITHIISIHESPQP----------------LLQDITYLRIPVADTPEVPIKKhFKECINFIHCCRLN--GGNCL
... ..|.|..|..  | ....| ...||....  |. ..                   .|.||..|. |  . .. . . |...|.. ....  || .|
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCFAGISRSTTIVTAYVMTVTGL-GWRDVLEAIKATR---PIANPNPGFRQQLEEFG
||| ||..|. |.| || | . .| . .|.|. ... |   | . ..|.....| .|.
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_STYX_pd Subfamily STYX 4-140 7e-27 87.5 In-house 11-155 (166) alignment 
Range on Protein: 4-140
Range on HMM: 11-155/166.0
GMTKVLPGLYLGNFIDAK--DLDQLGRNKITHIISIHESPQ-----P-LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRS
 | ..||||.|| .  |.   |..| .. ||||. | ....     | . ... || . |||..   | ... .  .||  .  .||. |||  ||||||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

TTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGW
...| ||.|   || .|.    ..  |   ||| || .||.|.  
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP8_pd Subfamily DSP8 4-138 1.6e-26 86.8 In-house 14-150 (159) alignment 
Range on Protein: 4-138
Range on HMM: 14-150/159.0
GMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHES-P-QPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTA
|.|..|. ||||   |. . . | .. |.... . .| | .  |..  .||.|| |. .  .   |.. ..||  .. . |..|||..||||||.|.. |
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
|.|    ..  .  . .|  ||  .||  | .|| |.
yimktlemsldeayrfvkekrptispnlnflgqLley
PTPc_motif_SM00404 5-138 8.7e-37 121.1 In-house 2-137 (140) alignment 
Range on Protein: 5-138
Range on HMM: 2-137/140.0
MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQP--LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY
....||.||||.  .|.....|  ..|||.|.. |. .     .....|.||. |. . .. |.......||. .. .||..||||.||.||| |...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
.|.  .| .....|..|  ||| .|| .| .|| |.
lmryrqlslaeayefvkerRpiispnlnfvrqLiey
subfamily_DSP12_pd Subfamily DSP12 5-138 2.2e-36 119.6 In-house 2-139 (155) alignment 
Range on Protein: 5-138
Range on HMM: 2-139/155.0
MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESP----QPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVT
....|||||||.  .... ..|   ||||..|. . .    ..  . .... |...|.||..| .|. |...||. .. ..|. ||||.||.||| |||.
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
||.|  ..|   . |...|. .| ..|| || .||  |
AYlmkkeklslekAlklvkekkpeiepNegFleQLklf
0043147 (Phosphotyrosine protein) phosphatases II 5-138 3.6e-35 116.6 In-house 19-156 (172) alignment 
Range on Protein: 5-138
Range on HMM: 19-156/172.0
MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHE----SPQPLLQDITYLRIPVADTPEVpIKKHFKECINFIHC--CRLNGGNCLVHCFAGISRSTTI
............. .|.....| ...||||... |     ..   ..|.||..|. | .   . ... |...||.   .. .|| .|||| ||..|. |.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VTAYVMTvTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
| || |   || . .... ... ||.| .||.....| .|
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyf
0045098 (Phosphotyrosine protein) phosphatases II 5-138 1.5e-28 95.4 In-house 22-267 (278) alignment 
Range on Protein: 5-138
Range on HMM: 22-267/278.0
MTKVLPGLYLGNFI-----------------------------------------DAKDLDQLGRNKITHIISI--------------------------
. ...|.|||||.                                           |.....|  ..||.|...                          
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------HESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRL--------------NGGNCLVHCFAGISRST
                           .. ..  .. . || .|  ..|. || |.| |...||. ..               .|| .|||| ||..|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TIVTAYVMTVT---GLGWRDVLEAIKATRPI-ANPNPGFRQQLEEF
|.| || |      |. . .... ..  ||. | .|... ..|.||
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyef
0037934 (Phosphotyrosine protein) phosphatases II 5-138 3.8e-28 94.1 In-house 39-237 (243) alignment 
Range on Protein: 5-138
Range on HMM: 39-237/243.0
MTKVLPGLYLGNF--------IDAKDLDQLGRNKITHIISIHE----------------------------------------------SPQPLLQDITY
...|.|.|.....        ..|.... | ...||.|... |                                               ... ...| |
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LRIPVAD----TPEVPIKKHFKECINFIHC-----CRLNGGNCLVHCFAGISRSTTIVTAYVMTVT-GLGWRDVLEAIKATRPI-ANPNPGFRQQLEEF
...|. |    .   .. ....|...||.      .. .|| .|||| ||..|. |...||.|    |... .... ... ||  | ..|.....| |.
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_DSP3_pd Subfamily DSP3 5-139 4e-27 88.8 In-house 11-154 (162) alignment 
Range on Protein: 5-139
Range on HMM: 11-154/162.0
MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESP-------QPLLQ--DITYLRIPVADTPEVPIKKHFKECINFIHCC-RLNGGNCLVHCFAGISR
.  | |.||.|.   ||| ..| .  |||..   |.        .   .  .|.|| ..| |.||. ..|.|..  .||.     . |  |||| .|.||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

STTIVTAYVMTVTGLGWRDVLEAIKATRPIAnPNPGFRQQLEEFG
|.|.| ||.| .  .   . ...... | |  || || .|| |. 
satlvlayLmirrkmtlveairtvrkkReil.PneGFlkqLaeld
subfamily_DSP19_pd Subfamily DSP19 6-138 1.8e-37 123.0 In-house 13-146 (152) alignment 
Range on Protein: 6-138
Range on HMM: 13-146/152.0
TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVM
..| | ||||    |.| ..| ..|||||...  . |.   .|.||| |.. |.||  . ...||...||.  | . |  |||| ||.|||...| ||.|
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
. . |  .. || ....|| ..|| || .||.|.
kkeelsleealelvrearpcikPneGFikqLkey
subfamily_DSP1_pd Subfamily DSP1 6-141 6.9e-36 117.8 In-house 19-155 (163) alignment 
Range on Protein: 6-141
Range on HMM: 19-155/163.0
TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQD-ITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVM
.|.|. ||||  ..| .|..| ...||.|. . .. .   .|  .| .... |.|.  |...|.| |.||.... ..|  |.|| ||||||.|.. ||.|
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWA
. . .   .  . .|  |.| .|| || .|| ..   
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
0049260 (Phosphotyrosine protein) phosphatases II 6-138 4.2e-31 103.1 In-house 9-145 (152) alignment 
Range on Protein: 6-138
Range on HMM: 9-145/152.0
TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQP----LLQDITYLRIPVADTPEVPIKKHFKECINFIHC-CRLNGGNCLVHCFAGISRSTTIVT
.........|.   |.....| ...||.|... |          | |.||..|. | .  ..  ...... ||.. .. .||..||||.||..|. |.| 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYVMTvTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
|| |   |. . .... ... ||.|.||||....| ||
aylml.lgvsleeavalvrekRpgavpnpgqlrflyef
subfamily_DSP6_pd Subfamily DSP6 6-139 4.5e-31 101.5 In-house 15-151 (158) alignment 
Range on Protein: 6-139
Range on HMM: 15-151/158.0
TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHES-PQPL--LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY
 ..|| ||||.  ||..|. | . || ... . .  |.     ....||.||. |  .  . |.| | |.||   | .  ..||||.|||||| |.. ||
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlay

VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFG
.|  . |   |  . .|. ..   ||  | .|| .| 
lmkklalslndaydlvkkrksnisPnfnfmgqlldfe
subfamily_Slingshot_pd Subfamily Slingshot 6-139 1.3e-27 90.2 In-house 20-154 (169) alignment 
Range on Protein: 6-139
Range on HMM: 20-154/169.0
TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVM
.|.   .|||   .| .|..| .|....|. .  |  .   ....||.| | |..|  . |...|  .||. .. .| ..||||  |.|||...| || |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFG
   ||   . || .|  | ...||.|| .||||. 
keyglsleealeyvkerrsvikPnkgflkqleeye
0042113 (Phosphotyrosine protein) phosphatases II 6-138 2.1e-25 85.0 In-house 48-238 (245) alignment 
Range on Protein: 6-138
Range on HMM: 48-238/245.0
TKVLPGLYLGNFIDAKDLD----QLGRNKITHIISIHE-----------------------------------------------SPQPLLQDITYLRIP
 .. |.......  .....    .| ...||.|... |                                                  . ...|.|...|
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

VADTPEVPIKKHFKECINFIHCCRL--NGGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
. | .. .. ... ....|.. ..   ..| .|||| ||..|. |...|| |     .  |. . .... ..  || | ..|.. ..| |.
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0051429 (Phosphotyrosine protein) phosphatases II 6-140 1.6e-24 82.5 In-house 17-222 (272) alignment 
Range on Protein: 6-140
Range on HMM: 17-222/272.0
TKVLPG-LYLGNFI---DAKDLDQLGRNKITHIISIHESP-------QPLLQDITYLRIPVADTPEVPIKKHF---------------------------
 .|.|| ||....    .|.|...| ...|..|... .          .....|.||..|. |. . .|  ..                           
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------KECINFIHCCRLnGGNCLVHCFAGISRSTTIVTAYVMTvTGLG--------------WRDVLEAIKATRPIANPNPGFR
                     ........ ..  ||..||||.||..|. |.| .. .   |..              .....| ..| || |.......
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

QQLEEFGW
..| |. .
lflyeall
0051082 (Phosphotyrosine protein) phosphatases II 6-136 9e-24 79.2 In-house 9-147 (151) alignment 
Range on Protein: 6-136
Range on HMM: 9-147/151.0
TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESP------QPLLQ-DITYLRIPVADTPEVPIKKHFKECINFIHCCRLN-GGNCLVHCFAGISRSTT
. | .|||....  | .|..| ...|..|... . .      ..| . .|..|.||. |.|. ..  .|.....|.. .. . .|..|||| ||..|. |
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

IVTAYVMTvTGLGWRDVLEAIKATRP-IANPNPGFRQQLE
.| .| |   |. . ..|| ....|| . .|| .|. || 
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
PTEN_1 7-138 4.1e-30 100.1 In-house 43-187 (196) alignment 
Range on Protein: 7-138
Range on HMM: 43-187/196.0
KVLPGLYLGNFIDA-KDLDQLGRNKITHIISIHESPQP----------LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRL--NGGNCLVHCFAGIS
.. .|||.|.  |. .|||.|. ..||....  | .              ....||..|. | .  .. ..|..| .||.....  ||...|||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
|| |.| || |   .|  .. || ... || ..||......|.|.
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlley
subfamily_LRR-DSP_pd Subfamily LRR-DSP 7-138 1.8e-27 90.1 In-house 122-254 (263) alignment 
Range on Protein: 7-138
Range on HMM: 122-254/263.0
KVLPGLYLGNFIDAKDLDQLGRNKITHI-ISIHEsPQPLLQDI-TYLRI-PVADTPEVPIKKHFKECINFIHCCRLNGGnCLVHCFAGISRSTTIVTAYV
.....|.||    |..   |  . .||| ... .  .||  ..  || |  . |..|  | .||.|   ||.  | .||  |||| ||.|||.|.| .|.
eiidklflGgldsannksilkdlgvthillavad.fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisyl

MTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
|    | ... |. ..  ||  .|||||..||  .
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkky
0040439 (Phosphotyrosine protein) phosphatases II 7-138 8.3e-26 86.5 In-house 31-241 (249) alignment 
Range on Protein: 7-138
Range on HMM: 31-241/249.0
KVLPGLYLGNFIDAKDLD------------------------QLGRNKITHIISIHESPQ----------------------------------------
..||||.|...|.|  .|                        .| ...||.|... .  .                                        
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

----PLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRL------NGGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANP
       ...|.| |.. | |.  . ..|.....||. .|       .|| .|||| ||..|. |...|| |     .  |.   .... ..  || | .
ltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NPGFRQQLEEF
||.. ..| |.
npeqyrflyea
0038934 (Phosphotyrosine protein) phosphatases II 7-138 6.7e-19 63.7 In-house 33-172 (194) alignment 
Range on Protein: 7-138
Range on HMM: 33-172/194.0
KVLPGLYLGNFIDAKDLDQLGRNKITHIISIHES-----PQPLLQ-DITYLRIPVADTPEVPIKKHFKECINFIHC--CRLNGGNCLVHCFAGISRSTTI
|....||  .. |  .. .|   |....|.....     |. . . .|.||..|. |  .||  .  .. ......   . .|| ..||| ||..|. |.
kyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtl

VTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
| || . . |.  .. .. ..  || | ||... ..| ..
vaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
0036941 (Phosphotyrosine protein) phosphatases II 7-137 9e-18 60.0 In-house 21-271 (297) alignment 
Range on Protein: 7-137
Range on HMM: 21-271/297.0
KVLPGLYLGNFIDAKDLDQLG----------------------------------------------------------RNKITHIISIHESPQP-----
..|| |.||..  |. .. |                                                            ...|.|... |  .      
ellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

---------------------------LLQDITYLRIPVAD----------------TPEVPIKKHFKECINFIHCCRL------NGGNCLVHCFAGISR
                           ||.|.|.  . | |                 |.  .  .......||. .|       .||  |||| ||..|
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

STTIVTAYVM--------TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEE
| |...|..|        .  |.   ...  ..  || | ..... ..| |
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye
0049772 (Phosphotyrosine protein) phosphatases II 8-142 2.1e-34 115.1 In-house 150-273 (314) alignment 
Range on Protein: 8-142
Range on HMM: 150-273/314.0
VLPGLYlgNFIDAKDLDQLGrnkithiiSIHESPQPLLQD-ITYLRIPVADtPEVPIKKHFKECINFIHCCrLNGGNCLVHCFAGISRSTT-IVTAYVMT
 |.|..  |. .|.||..|         ... .|. . .  |.|||||| | ...|. ..|.|...||. .  .||. |||| ||..|..| .|.||.| 
ildgng..neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk

VTGLGWRDVLEAIKATRPiANPNPGFRQQLEEFGWAS
  |. ....|| ....|| .||||||..|||.. .  
llgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_STYXL1_pd Subfamily STYXL1 8-138 3.3e-16 52.9 In-house 14-149 (157) alignment 
Range on Protein: 8-138
Range on HMM: 14-149/157.0
VLPG-LYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDIT----YLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY
|||| |||||. .|..       |.   . .    ..|.. ..     |.|.| |..|  . ...|| ..||.  . .|   ||    |||||.... ||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
.|    .  .. .. .|  ..  .|| .| .||.|.
lmyskkitlkkaykylkkCkenvkPnrafveqlseW
subfamily_MKPLT_pd Subfamily MKPLT 11-138 7.2e-21 68.4 In-house 28-156 (164) alignment 
Range on Protein: 11-138
Range on HMM: 28-156/164.0
GLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGL
 |||||  .|..   |   |||||. .  |  .   . . ||.. | |...  . ....   .|.     .||  ||||  | |||...  |....  | 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

GWRDVLEAIKATRPIANPNPGFRQQLEEF
  ..  | .|  | |..|| || .|| .|
tlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 11-138 7.2e-21 68.4 In-house 28-156 (164) alignment 
Range on Protein: 11-138
Range on HMM: 28-156/164.0
GLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGL
 |||||  .|..   |   |||||. .  |  .   . . ||.. | |...  . ....   .|.     .||  ||||  | |||...  |....  | 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

GWRDVLEAIKATRPIANPNPGFRQQLEEF
  ..  | .|  | |..|| || .|| .|
tlkeayeylkerrsivapnrGflkqlakf
DSPc Dual specificity phosphatase, catalytic domain 12-138 4.4e-33 109.0 Pfam-A 1-130 (133) alignment 
Range on Protein: 12-138
Range on HMM: 1-130/133.0
LYLGNFIDAKdLDQLGRNKITHIISIH-ESPQPL---LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVT
||||.  .|. |..|  ..||..|..  | |..     ..|.|||||| |. |  | |...|...||. .. .|...|||| |||||| |...|| |.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLGWRDVLEAIKATRPIANPNPGFRQQLEEF
.|  .. .|..|  |.. .|| || .|| |.
nlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 12-138 4.4e-33 109.0 In-house 1-130 (133) alignment 
Range on Protein: 12-138
Range on HMM: 1-130/133.0
LYLGNFIDAKdLDQLGRNKITHIISIH-ESPQPL---LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVT
||||.  .|. |..|  ..||..|..  | |..     ..|.|||||| |. |  | |...|...||. .. .|...|||| |||||| |...|| |.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLGWRDVLEAIKATRPIANPNPGFRQQLEEF
.|  .. .|..|  |.. .|| || .|| |.
nlslneAyefvkerrskispnagflrqLley
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-138 8.5e-23 74.5 In-house 15-143 (148) alignment 
Range on Protein: 12-138
Range on HMM: 15-143/148.0
LYLGNFIDAKDLDQLGRNKITHIISIHESPQPLL--QDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGL
|.||.   | ||..|    .|.|..  .. .  |  . | || ....| |.  ... |.. |.|..  . .|. .|||.  |.|||. .. ....     
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

GWRDVLEAIKATRPIANPNPGFRQQLEEF
  .. |...|  |.  .||.|| .|| |.
slkealalvkskrryvdpnlgfLkqLael
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 12-139 3.8e-19 62.5 In-house 10-149 (154) alignment 
Range on Protein: 12-139
Range on HMM: 10-149/154.0
LYLGNFIDAKDLDQLGRNKITHIISI-HESPQPLLQD---------ITYLRIPVADTPEVPIKKHFKECINFIHCCR--LNGGNCLVHCFAGISRSTTIV
||.. |  | .  .|  ..|..|. .   ..  . ..         | ||.. . | ..  | .... . .||.     .. .. |||. .|.|||....
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

TAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFG
 .|.|    . .   || .| .|.| .|| || .||| |.
isylmdklkislslalellkdsryiikPnqGflkqleife
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 12-135 2.7e-15 49.7 In-house 6-134 (145) alignment 
Range on Protein: 12-135
Range on HMM: 6-134/145.0
LYLGNFIDAKDLDQLGRNKITHIISI-----HESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTV
|| |  . |.|.  |    |. |. .       | .   ..|. | |   |     . .|| |  .||   . .|   .|||.||.||| |.  |..|  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

TGLGWRDVLEAIKATRPIANPNPGFRQQL
 ..   .    ... |  | ||  | ..|
cnmtlseaarqvrsnrllaypnvtflknl
0039614 (Phosphotyrosine protein) phosphatases II 18-138 5.2e-20 67.5 In-house 93-284 (297) alignment 
Range on Protein: 18-138
Range on HMM: 93-284/297.0
IDAKDL--------------------DQLGRNKITHIISIHESPQP--------------------------LLQDIT-----------------YLRIP
.|  ||                      . ....|.|... .                               |...|                 .. ..
vdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytg

VADTPEVPIKKHFKECINFIHCCRL---NGGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
  |    |. ... | ..... ..    .|| .|||| ||..|. |...|| |     .  |. . .... ..  || | ..|.. ..| ..
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0045450 (Phosphotyrosine protein) phosphatases II 21-138 7.8e-26 86.9 In-house 90-299 (307) alignment 
Range on Protein: 21-138
Range on HMM: 90-299/307.0
KDL--------------------------------DQLGRNKITHIISIHESPQP-----------------------------LLQDITYLRIPVADT-
                                    .| ....|.|... |.                                 |...|.....| |. 
syvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdld

----------------PEVPIKKHFKECINFIHCCRL------NGGNCLVHCFAGISRSTTIVTAYVMTVTG--------LGWRDVLEAIKATRPIANPN
                |.  . ..|.|...||. .|       .|| .|||| ||..|. |...||.| . .        . ...... ... || | .|
gtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn

PGFRQQLEEF
|.. ..| |.
peqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 26-163 1.7e-23 78.8 In-house 106-309 (317) alignment 
Range on Protein: 26-163
Range on HMM: 106-309/317.0
LGRNKITHIISIHESPQP----------------------------LLQDITYLRIPVADT----------------PEVPIKKHFKECINFIHCCRLN-
. ....|.|... |. ..                             |..||.....| |.                |.  . ........|.. .| . 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---GGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF-------------GWASSQKLRRQLEERFGESPF
   || .|||| ||..|. |...||.|     .  |. . .... ... || | ..|.. ..| ..              .    || ..|.. ......
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk

RDEE
 .|.
lkek
subfamily_DSP23_pd Subfamily DSP23 26-123 2.6e-06 22.2 In-house 27-126 (148) alignment 
Range on Protein: 26-123
Range on HMM: 27-126/148.0
LGRNKITHIISIHESPQPLLQ---DITYLRIPVADTpEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATR
|  . . ...|. |  .|  .   ..|. |. . |    |  .  .| .. ..    ..    |||  |  |. |... |..   .|   . .  ..  |
lldlgvrylvslteegrphveatpnltlvrlriddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr

P
|
p
0043336 (Phosphotyrosine protein) phosphatases II 28-138 2.4e-16 55.5 In-house 110-272 (278) alignment 
Range on Protein: 28-138
Range on HMM: 110-272/278.0
RNKITHIISI------------------------------------------------HESPQPLLQDITYLRIPVADTPEvPIKKHFKECINFIHCCRL
 ...|.|...                                                 ...    . . || .|  ..|| ... ... .  ...... 
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrealed

NGGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
..|  |||| ||..|. |....|..     .  |.   .... ..  || | ..| . ..| |.
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
PTPlike_phytase Inositol hexakisphosphate 36-105 6.1e-08 27.4 Pfam-A 81-148 (149) alignment 
Range on Protein: 36-105
Range on HMM: 81-148/149.0
SIHESPQPLLQDITYLRIPVADTpEVPIKKHFKECINFIHCCrLNGGNCLVHCFAGISRSTTIVTAYVMT
 . |  .   ....| |||. |    | .... . ...|.    .    ...| ||  |.|| .. . . 
evyeeelaegfgvkYvRipitde.qapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 36-105 6.1e-08 27.4 In-house 81-148 (149) alignment 
Range on Protein: 36-105
Range on HMM: 81-148/149.0
SIHESPQPLLQDITYLRIPVADTpEVPIKKHFKECINFIHCCrLNGGNCLVHCFAGISRSTTIVTAYVMT
 . |  .   ....| |||. |    | .... . ...|.    .    ...| ||  |.|| .. . . 
evyeeelaegfgvkYvRipitde.qapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadLl
0046845 (Phosphotyrosine protein) phosphatases II 39-129 3.4e-10 35.2 In-house 161-260 (284) alignment 
Range on Protein: 39-129
Range on HMM: 161-260/284.0
ESPQPLLQDITYLRIPVADTPEVpiKKHFKECINFIHCCRLN---GGNCLVHCFAGISRSTTIVTAYVMTVT--------GLGWRDVLEAIKATRPIANP
...   .. . |. .|  ..|.    ... | ..... .. |   ||  .||| ||..|. |.......           |.   ...  ..  || .  
tgesrtvthfhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

NP
..
tl
subfamily_PTPMT1_pd Subfamily PTPMT1 47-138 6.1e-16 53.3 In-house 73-164 (171) alignment 
Range on Protein: 47-138
Range on HMM: 73-164/171.0
DITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF
....|.... |  | |  .. .. ..||.  . .|    ||| || .||.|.|..|.|. . |   . |.|.|. |.| . .   ...|.|.
gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey
subfamily_Laforin_pd Subfamily Laforin 47-125 2.2e-09 30.4 In-house 76-154 (183) alignment 
Range on Protein: 47-125
Range on HMM: 76-154/183.0
DITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIA
 ..|. .|. |       . . ... ..|.   .|    ||| ||. |||.||  ... | |   . |   . | ||..
glayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
0047943 (Phosphotyrosine protein) phosphatases II 48-135 3.3e-13 45.2 In-house 171-264 (273) alignment 
Range on Protein: 48-135
Range on HMM: 171-264/273.0
ITYLRIPvaDTPEVPIKKHFKECINFIHCCRL---NGGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNPGFRQQL
. |. .|  |    |  ... |.|.... ..    ..|  .||| ||..|. |.......     .  |.   ...  ..  || . ..| ....|
fhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
PTPc_DSPc_SM00012 50-105 2.5e-08 29.4 In-house 7-63 (105) alignment 
Range on Protein: 50-105
Range on HMM: 7-63/105.0
YLRIPVADTPE--VPIKKHFKECINFIHCCRLnGGNCLVHCFAGISRSTTIVTAYVMT
|. .|   .||   .| ...... .. . .   .....|||.||..|. |.|..... 
ytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldill
0051299 (Phosphotyrosine protein) phosphatases II 52-130 6.7e-12 40.9 In-house 186-273 (288) alignment 
Range on Protein: 52-130
Range on HMM: 186-273/288.0
RIPVADTPEVPIKKHFKECINFIHCCRLN----GGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNPG
 . . . |.  .  .......|.. .|      || ..||| ||..|. |.......     .  |. . .... ..  || . ..| 
hfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0050432 (Phosphotyrosine protein) phosphatases II 59-129 4.6e-12 41.4 In-house 208-285 (308) alignment 
Range on Protein: 59-129
Range on HMM: 208-285/308.0
P--EVPI-KKHFKECINFIHCCRlNGGNCLVHCFAGISRSTTIVTAYVM-----TVTGLGWRDVLEAIKATRPIANPNP
|   ||   ... . ..... .. .||...||| ||..|. |.......     .  |. . ...  ..  || . ..|
pdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_CDKN3_pd Subfamily CDKN3 60-119 7.7e-06 19.6 In-house 111-171 (202) alignment 
Range on Protein: 60-119
Range on HMM: 111-171/202.0
EVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVT-GLGWRDVLEAIK
 ||      . .. .. .  .. . ||||. |. ||. ...  .. .   . ..| .. ..
lvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklr
subfamily_MSG5_pd Subfamily MSG5 63-144 1e-12 41.5 In-house 81-162 (165) alignment 
Range on Protein: 63-144
Range on HMM: 81-162/165.0
IKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQ
| | . .  . ||. . ..   ||||  |.|||.... ||.|   .|  ||  . .|.     .|. |.  || |.. | |.
ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalsk
Y_phosphatase Protein-tyrosine phosphatase 63-105 6.5e-06 21.1 Pfam-A 148-194 (235) alignment 
Range on Protein: 63-105
Range on HMM: 148-194/235.0
IKKHFKECINFIHCCRLNG----GNCLVHCFAGISRSTTIVTAYVMT
.... |. ...|. .. .     |...||| ||..|. |.|.. .. 
vpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 63-105 6.5e-06 21.1 In-house 148-194 (235) alignment 
Range on Protein: 63-105
Range on HMM: 148-194/235.0
IKKHFKECINFIHCCRLNG----GNCLVHCFAGISRSTTIVTAYVMT
.... |. ...|. .. .     |...||| ||..|. |.|.. .. 
vpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 68-105 4e-06 21.0 In-house 196-234 (307) alignment 
Range on Protein: 68-105
Range on HMM: 196-234/307.0
KECINFIHCCRLNGGNCLVHCFAGISRSTTIVT-AYVMT
  .||...  | .    .||| ||. || |||. ..|. 
ltainlleavrydtnpvvvhcsaGvGrsGtivaislvqd
0048567 (Phosphotyrosine protein) phosphatases II 70-123 2e-07 25.5 In-house 63-119 (157) alignment 
Range on Protein: 70-123
Range on HMM: 63-119/157.0
CINFIHCCRLNGGNCLVHCFAGI---SRSTTIVTAYVMTVTGLGWRDVLEAIKATRP
  .|.....|.|.   ||| ||    .|. |.. .| . . |.  ..... ..  ||
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
subfamily_CDC14_pd Subfamily CDC14 72-123 4.4e-06 20.8 In-house 254-305 (328) alignment 
Range on Protein: 72-123
Range on HMM: 254-305/328.0
NFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRP
.|.. .    |.  ||| ||. |  |....|.|   ..   ...  .. .||
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP