Gene DUSP22 in Homo sapiens

Synonym: JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, RP11-328C17.1, DUSP22

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP021_AA protein Get Run
HsapP021_AA_2-146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 3-141 2e-41 136.9 In-house 21-169 (178) alignment 
Range on Protein: 3-141
Range on HMM: 21-169/178.0
NGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVH----------DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECR-LRGESCLVHCLAG
.....||||||.|.. .|.| |.| ....|||...           |   |. .|..||.||  |.. ..|..|| | ..||.|..  .|. .|||| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVTLVIAYIMTVTDFGWEDALHTVRAGRScANPNVGFQRQLQEFEKH
|.|| |||.||.| . .. .|.|.. ||. |. ..|| |..|||.|||..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
0048179 (Phosphotyrosine protein) phosphatases II 3-140 1.1e-37 124.2 In-house 2-142 (144) alignment 
Range on Protein: 3-140
Range on HMM: 2-142/144.0
NGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHD---SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLV
. ...||||||.|.. .|.| |.| |...|..... .    . .  ||..||..|  | .  .|. .. | ..||.|.. .|. .|||| |||.|. |||
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

IAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.||.| . .. .|.||. ||. |..|.|| |. |.|.|.||
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0046846 (Phosphotyrosine protein) phosphatases II 3-141 5.2e-31 103.1 In-house 10-171 (176) alignment 
Range on Protein: 3-141
Range on HMM: 10-171/176.0
NGMNKILPGLYIGNFK----------DARDAEQLSKNKVTHILSVHDS------------ARPMLEGVKYLCIPAADSPSQNLtRHFKESIKFIHECRLR
.... |...|..|..            | . |.| ....|..... .              . . .|..||..|  |    .| ... | ..||.|.. .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GESCLVHCLAGVSRSVTLVIAYIMTV-TDFGWEDALHTVRAGRS-CANPNVGFQRQLQEFEKH
|.  |||| ||..|. |||.||..    .. .|.||..||. |. .| .. .. |.|.|||..
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_DSP15_pd Subfamily DSP15 4-154 1.4e-76 249.7 In-house 1-151 (151) alignment 
Range on Protein: 4-154
Range on HMM: 1-151/151.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
|..|.|||||.|||.|..|.|.|.....||||||||.|...|. ..|.||.|.|.||..|...||||..|||.|||..|..|||||||||||||||.||.
giskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEY
||||...|.|||....| ||.||||.||.|||.|.||.....||..||||.
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlkeef
0048076 (Phosphotyrosine protein) phosphatases II 4-141 7.6e-38 124.7 In-house 3-141 (145) alignment 
Range on Protein: 4-141
Range on HMM: 3-141/145.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSV-HDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
....||||||.|.. .|.| |.| ....|..|.. ..   .  .|..||..|  | . ..|.... | ..||.|.. .|. .|||| |||.|. |||.||
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
.|   .. .|.||. ||. |..|.||.|..|.|.|||..
lmlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_DSP14_pd Subfamily DSP14 4-142 2.4e-36 119.0 In-house 6-144 (157) alignment 
Range on Protein: 4-142
Range on HMM: 6-144/157.0
GMNKILPGLYIGnFKDARDAEQLSKNKVTHILSVH-DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
....| | |...    |.. |.|.|.|.|.|. |  .   . |...... .|..|.|...|..|| | .. |.| . .|  .|||| |||||| .|..||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
.|       ..| ..|.. |.  .||||| .||...||. 
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0041856 (Phosphotyrosine protein) phosphatases II 4-149 2.6e-34 113.8 In-house 18-179 (182) alignment 
Range on Protein: 4-149
Range on HMM: 18-179/182.0
GMNKILPGLYIGNFKD--------------ARDAEQLSKNKVTHILSVHDSA----RPMLEGVKYLCIPAADSPSQNltrhFKESIKFIHECRLRGESCL
....|...||.|....              |.. ..| ....|.|... .      . . .|..||..|  | .  .    . | ..||.|.. .|. .|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRS--CANPNVGFQRQLQEFEKHEVHQYRQW
||| |||.|. |||.||.| . ....|.|...||  |.  . .|| .| .||...|.... ..|..
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
0049772 (Phosphotyrosine protein) phosphatases II 4-160 1.3e-32 109.2 In-house 125-293 (314) alignment 
Range on Protein: 4-160
Range on HMM: 125-293/314.0
GM---------------------NKILPGLYigNFKDARDAEQLSknkvthilSVH-DSARPMLEGVKYLCIPAADsPSQNLTRHFKESIKFIHECrLRG
.|                     . ||.|..  |. .|.| |.|         ... |  ..  .|.|||.||  | .|..|...|.| ..||.|.  .|
vmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkg

ESCLVHCLAGVSRSVT-LVIAYIMTVTDFGWEDALHTVRAGRScANPNVGFQRQLQEFEKHE--VHQYRQWLKEEYGESPLQ
.  |||| ||..|. | .|.||.|   .. .|.||. ||. |. .||| || .||...|...  ...| ..||..|.  ...
gpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkkfyeyleen
subfamily_DSP3_pd Subfamily DSP3 4-143 2.4e-31 102.6 In-house 10-158 (162) alignment 
Range on Protein: 4-143
Range on HMM: 10-158/162.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSaR--------PMLE--GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLR-GESCLVHCLAGV
 .. . |.||.|. . |.| ..| |  .||.|   .. |         . .  ..||| ... |.|. .| ..|... |||.|   .     |||| .||
evdevypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCaNPNVGFQRQLQEFEKHEV
||| |||.||.| . ..   .|..|||. |.   || || .||.|.... .
sRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelk
subfamily_DSP8_pd Subfamily DSP8 4-141 8.7e-31 100.6 In-house 14-153 (159) alignment 
Range on Protein: 4-141
Range on HMM: 14-153/159.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSV--HDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIA
|...||. ||.|  ||. . | |||. ....| .  .. .  .|. .|.| .|  |. . .|   |..|..||  ..    ..|||.||| ||| |..||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|||   ... ..| . |.  |   .||. |. || |.||.
yimktlemsldeayrfvkekrptispnlnflgqLleyeke
subfamily_STYX_pd Subfamily STYX 4-146 2.7e-28 92.1 In-house 11-161 (166) alignment 
Range on Protein: 4-146
Range on HMM: 11-161/166.0
GMNKILPGLYIGNFKDARDA--EQLSKNKVTHILSVHDSA-----RPML-EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRS
 |..|||||..| .  |  .  |.| |. .|||. . ..      .| . .  .|| .  ||.. .|. |.. .  .|| ..  .|   |||  ||.|||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

VTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQY
 .|||||||    . . .| . |.  | | ||| || .||.|.|   . ..
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakl
PTPc_motif_SM00404 5-140 5.2e-40 131.6 In-house 2-139 (140) alignment 
Range on Protein: 5-140
Range on HMM: 2-139/140.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP--MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
...|||.||.|. ..| ....|.|...||...| .. .     .|...|.||  |. ...|...... ..||.... .|...|||| ||||||.||.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.|.   . ...|.. |.  |.. .||..| |||.|.||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP12_pd Subfamily DSP12 5-143 4.3e-39 128.4 In-house 2-144 (155) alignment 
Range on Protein: 5-143
Range on HMM: 2-144/155.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSA----RPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVI
...||||||.|. ... . |.|.. |.||.|||   .    ..    |... |...|.|.... .|. | ..||.|.. .... |||| ||||||||.||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
||.|  ...  |.||..|.. .. ..|| ||..||. |||  .
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
subfamily_DSP10_pd Subfamily DSP10 5-141 1.2e-38 126.5 In-house 14-152 (159) alignment 
Range on Protein: 5-141
Range on HMM: 14-152/159.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEG--VKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
. ..|| |..|. |||.| . | . ..|..| |  |   . |.  .||  ||. |. .||| ..|.|...||.| | .|.. |||| ||.|||.|.||||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
.|. ..   .|| . |.  |.   ||..|  || ||||.
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
0043147 (Phosphotyrosine protein) phosphatases II 5-149 4.7e-38 126.0 In-house 19-167 (172) alignment 
Range on Protein: 5-149
Range on HMM: 19-167/172.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHD----SARPMLEGVKYLCIPAADSPSQnLTRHFKESIKFIHE--CRLRGESCLVHCLAGVSRSVTL
......... ... .| . ..| ....|||... .        . .|..||..|  | . . |.... | ..||.|  .. .|. .|||| |||.|..||
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VIAYIMTvTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQW
|.||.|   .. .|.|...||. |..| .| ...|.|..|||. .......
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllllkdsl
0049260 (Phosphotyrosine protein) phosphatases II 5-140 6.3e-32 105.7 In-house 8-147 (152) alignment 
Range on Protein: 5-140
Range on HMM: 8-147/152.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSAR----PMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHE-CRLRGESCLVHCLAGVSRSVTLV
..........|.   | . ..| ....|.|... .        . .. .||..|  |.. ..|. .... ..||.. .. .|. .|||| |||.|. |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYIMTvTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.||.|   .. .|.|.  ||. |..|.|| |. |.|.||||
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0045098 (Phosphotyrosine protein) phosphatases II 5-145 6.5e-31 103.2 In-house 22-274 (278) alignment 
Range on Protein: 5-145
Range on HMM: 22-274/278.0
MNKILPGLYIGNFK-----------------------------------------DARDAEQLSKNKVTHILSV--------------------------
...|.|.||.||..                                          | . ..| ....|.|...                          
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------HDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRL--------------RGESCLVHCLAGVSRSV
                           .|     .. ..||..|  ..||......| | ..||.|..               .|. .|||| |||.|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TLVIAYIMTVT---DFGWEDALHTVRAGRSC-ANPNVGFQRQLQEFEKHEVHQ
|||.||.|       . ...|....|  | . | .| ...|.| ||. . ...
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0037934 (Phosphotyrosine protein) phosphatases II 5-141 3.2e-29 97.6 In-house 39-240 (243) alignment 
Range on Protein: 5-141
Range on HMM: 39-240/243.0
MNKILPGLYIGNF--------KDARDAEQLSKNKVTHILSVHD----------------------------------------------SARPMLEGVKY
. ...|.|.....        ..| . . | ....|.|... .                                                 . .....|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LCIPAAD----SPSQNLTRHFKESIKFIHE-----CRLRGESCLVHCLAGVSRSVTLVIAYIMTVT-DFGWEDALHTVRAGRSC-ANPNVGFQRQLQEFE
...|  |    .  ..| ....| ..||.|     .. .|. .|||| |||.|. ||..||.|    ....|.|....|. |.. | .. .. |.|.|..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

KH
..
le
0036282 (Phosphotyrosine protein) phosphatases II 5-140 8e-27 89.4 In-house 12-167 (174) alignment 
Range on Protein: 5-140
Range on HMM: 12-167/174.0
MNKILPGLYIGNFKDArDAEQLSKNKVTHILSVHDSARP----------------MLEGVKYLCIPAADSPSQNLTRhFKESIKFIHECRLR--GESCLV
.. |.|.|..|..  | . |.| ....|..... ..  .                  .|..||..|  |    .|.  . | .||..|....  |  .||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCLAGVSRSVTLVIAYIMTVTDF-GWEDALHTVRAGR---SCANPNVGFQRQLQEFEK
|| |||.|. |||.||.| .  . . .|||..||. |   ... .. .. |.|..|||
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0051082 (Phosphotyrosine protein) phosphatases II 5-139 4.5e-22 73.7 In-house 8-150 (151) alignment 
Range on Protein: 5-139
Range on HMM: 8-150/151.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSA-------RPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLR-GESCLVHCLAGVSRSV
.. . .|||....  |.. |.| ......|... .         .   .|...|.||  | | ..|  .|.. ..|.....   .  .|||| ||..|. 
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TLVIAYIMTvTDFGWEDALHTVRAGRS-CANPNVGFQRQLQEFE
|||..|.|   .. .|.||. .|. |  . .|| .|. ||....
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
0036941 (Phosphotyrosine protein) phosphatases II 5-143 7.3e-19 63.6 In-house 19-277 (297) alignment 
Range on Protein: 5-143
Range on HMM: 19-277/297.0
MNKILPGLYIGNFKDARDAEQLSKN----------------------------------------------------------KVTHILSVHDSARPM--
. ..|| |..|... |.  | |.||                                                          .||.|... .       
feellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

------------------------------LEGVKYLC----------------IPAADSPSQNLTRHFKESIKFIHECRL------RGESCLVHCLAGV
                              |.....                  .   . |  ..  .... ..||...|       .|.  |||| |||
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSVTLVIAYIM--------TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
.|| |...|..|        .   .   .|....|  | .| ..... |.| |.. . .
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_DSP19_pd Subfamily DSP19 6-141 1.7e-39 129.6 In-house 13-149 (152) alignment 
Range on Protein: 6-141
Range on HMM: 13-149/152.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVH-DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
 .. | ||.|    | | |.|...|.||||.|  .  .   . ..||.|.  | | ..|....||...||.| |      |||| ||||||...||||.|
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
. ..   |.||..||. | |..|| ||..||.|.|..
kkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP1_pd Subfamily DSP1 6-145 3.8e-36 118.6 In-house 19-159 (163) alignment 
Range on Protein: 6-145
Range on HMM: 19-159/163.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEG-VKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
.|||. ||.|  ..| . |.|.....|.|| |  .   . |   .| ...  |||..... .|.| |.||.|..  .   |.|| ||.||| ||..||.|
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQ
. . .  |.| . |.  ||. .||.||..|| ..||.. ..
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_Slingshot_pd Subfamily Slingshot 6-139 8.1e-30 97.4 In-house 20-154 (169) alignment 
Range on Protein: 6-139
Range on HMM: 20-154/169.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLE-GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
 ||   .|.|   .| . |.|..|.|..|| |      . .  ..|| |   |.....| ....|. |||.... .| ..||||  ||||| . |||| |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFE
   ..  |.||. |.  ||...|| || .||.|.|
keyglsleealeyvkerrsvikPnkgflkqleeye
0042113 (Phosphotyrosine protein) phosphatases II 6-141 2.5e-25 84.8 In-house 48-241 (245) alignment 
Range on Protein: 6-141
Range on HMM: 48-241/245.0
NKILPGLYIGNFKDARDAE----QLSKNKVTHILSVHD-----------------------------------------------SARPMLEGVKYLCIP
 .| |.......  . . |    .| ....|.|... .                                                  . .|.. |...|
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

AADSPSQNLTRHFKESIKFIHECRL--RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
  | .  .|.... . ..|.....   ... .|||| |||.|. |...||.|     .  .. .|.|.. .|  |..| .. .. |.|.|....
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051429 (Phosphotyrosine protein) phosphatases II 6-155 1.6e-22 75.9 In-house 17-248 (272) alignment 
Range on Protein: 6-155
Range on HMM: 17-248/272.0
NKILPG-LYIGNFK---DARDAEQLSKNKVTHILSVHDSA-------RPMLEGVKYLCIPAADSPSQNLTRHF---------------------------
....|| || ...    .|.| ..| ......|... .          . ..|..||..|  |.  .  . ..                           
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------KESIKFIHECRLrGESCLVHCLAGVSRSVTLVIAYIMTvTDFG--------------WEDALHTVRAGRSCANPNVGFQ
                     .. ........  |. .|||| ||..|. |.| ....   ...              .|.|.. .|| | .|... .. 
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

RQLQEFEKHEV-----------HQYRQWLKEEYG
..|.|.... .           ... ....||||
lflyeallellrsllsvraeyllaaldaideeyG
0038934 (Phosphotyrosine protein) phosphatases II 6-142 6.6e-21 70.3 In-house 32-176 (194) alignment 
Range on Protein: 6-142
Range on HMM: 32-176/194.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVH------DSARPMLEGVKYLCIPAAD---SPSQNLTRHFKESIKFIHEcRLRGESCLVHCLAGVSRSV
.| ...||  ...|  .  .| . |........      |  . .  |..|| .|  |   .||......| . ...... .  |. ..||| ||..|. 
dkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtG

TLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
|||.||.. . ..  |.|....|  |  | ||... ..|... |. 
tlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_DSP6_pd Subfamily DSP6 7-141 3.8e-39 127.7 In-house 16-153 (158) alignment 
Range on Protein: 7-141
Range on HMM: 16-153/158.0
KILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP---MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
.||| ||.|. ||| . | |.| |. ..| |           . .||| ||. |  ||||...| |.|.|| | | . ...|||||||.|||||...||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|  . .  .|| . |.. .|   ||  |  || .||..
mkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_LRR-DSP_pd Subfamily LRR-DSP 7-141 1.4e-32 106.8 In-house 122-257 (263) alignment 
Range on Protein: 7-141
Range on HMM: 122-257/263.0
KILPGLYIGNFKDARDAEQLSKNKVTHI-LSVHDSARPMLEGVKYLCI-PAADSPSQNLTRHFKESIKFIHECRLRGeSCLVHCLAGVSRSVTLVIAYIM
.|...|..|  . | ..  | .. |||| |.| |      .  ||| |  . | .  .. .||.|   ||.| | .|   |||| |||||| ||||.|.|
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
    . ...||  |  .|.  .|| ||. ||. .||.
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
PTEN_1 7-142 8e-31 102.4 In-house 43-191 (196) alignment 
Range on Protein: 7-142
Range on HMM: 43-191/196.0
KILPGLYIGNFKDA-RDAEQLSKNKVTHILSVHDSARP----------MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRL--RGESCLVHCLAGVS
.| .|||.|. ||. .| ..| ....|..... .              . .||.|| .|  | . ..| ..|..  .||. ...  .|. .|||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
||.|.|.|| |    .  ..||  ||. |....|| ..|..|.|...  
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0040439 (Phosphotyrosine protein) phosphatases II 8-141 3.2e-25 84.6 In-house 32-244 (249) alignment 
Range on Protein: 8-141
Range on HMM: 32-244/249.0
ILPGLYIGNFKDARDAE------------------------QLSKNKVTHILSVHDSAR-----------------------------------------
|||||. ... .|   .                        .| ....|.|... .  .                                         
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---PMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRL------RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPN
      | ...|.|.  | | ...  .|.. ..||...|       .|. .|||| |||.|. |...||.|     .  ..  |.|....|  |..| .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

VGFQRQLQEFEKH
 .. |.|.|....
peqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 8-142 7.4e-23 74.5 In-house 14-153 (157) alignment 
Range on Protein: 8-142
Range on HMM: 14-153/157.0
ILPG-LYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKY----LCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
.||| ||.||.|.| . .     ||   . |   | ....||.     | |.  |..  .|  ..|| ..||.. . .||  ||    |.|||....|||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
.|   ..  ..|.. ..  ..  .|| .|  ||.|.||. 
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 9-141 6.9e-21 68.2 In-house 7-151 (154) alignment 
Range on Protein: 9-141
Range on HMM: 7-151/154.0
LPGLYIGNFKDARDAEQLSKNKVTHILSV-HDSARPMLE-------G--VKYLCIPAADSPSQNLTRHFKESIKFIHECR--LRGESCLVHCLAGVSRSV
   |||. |. | .  .| ......|| |   .   . .       |  ..|| .   | . ........ . .||..    .. .  |||. .||||| 
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
.|.|.|.|      .  ||  ..  |   .|| || .||. |||.
allisylmdklkislslalellkdsryiikPnqGflkqleifeke
DSPc Dual specificity phosphatase, catalytic domain 12-140 6e-36 118.2 Pfam-A 1-132 (133) alignment 
Range on Protein: 12-140
Range on HMM: 1-132/133.0
LYIGNFKDARdAEQLSKNKVTHILSVHDSARP----MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVT
||.|. ..|   ..|.|...|....| .. .       .  .||.||  |. .........|...||.... .|...|||| ||.||| ||.|||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 .  ..|.. |.  ||. .||.||.||| |.|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 12-140 6e-36 118.2 In-house 1-132 (133) alignment 
Range on Protein: 12-140
Range on HMM: 1-132/133.0
LYIGNFKDARdAEQLSKNKVTHILSVHDSARP----MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVT
||.|. ..|   ..|.|...|....| .. .       .  .||.||  |. .........|...||.... .|...|||| ||.||| ||.|||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 .  ..|.. |.  ||. .||.||.||| |.|.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-142 9e-27 87.4 In-house 15-147 (148) alignment 
Range on Protein: 12-142
Range on HMM: 15-147/148.0
LYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLE--GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDF
|..|. | | |.|.| .  ||.| .   . . .|.  |..|| .. .| | ..|   |.. |.|... . .|. .|||.  |||||  |......   . 
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

GWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
  ..||  |.  |   .|| || .||.|.|. |
slkealalvkskrryvdpnlgfLkqLaeleqae
subfamily_MKPLT_pd Subfamily MKPLT 12-140 2.5e-24 79.6 In-house 29-158 (164) alignment 
Range on Protein: 12-140
Range on HMM: 29-158/164.0
LYIGNFKDARDAEQLSKNKVTHILSVHDS-ARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFG
|| || |.|.... | . |.|||. |    .    . |.|| .   | . ..|. ...   ||. .    |   ||||  |.||| .  .|....   . 
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

WEDALHTVRAGRSCANPNVGFQRQLQEFEK
 ..| . ..  ||...|| || .|| .||.
lkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 12-140 2.5e-24 79.6 In-house 29-158 (164) alignment 
Range on Protein: 12-140
Range on HMM: 29-158/164.0
LYIGNFKDARDAEQLSKNKVTHILSVHDS-ARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFG
|| || |.|.... | . |.|||. |    .    . |.|| .   | . ..|. ...   ||. .    |   ||||  |.||| .  .|....   . 
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

WEDALHTVRAGRSCANPNVGFQRQLQEFEK
 ..| . ..  ||...|| || .|| .||.
lkeayeylkerrsivapnrGflkqlakfee
0045450 (Phosphotyrosine protein) phosphatases II 24-141 6.5e-26 87.2 In-house 125-302 (307) alignment 
Range on Protein: 24-141
Range on HMM: 125-302/307.0
EQLSKNKVTHILSVHDSARP-----------------------------MLEGVKYLCIPAADS-----------------PSQNLTRHFKESIKFIHEC
..| ...||.|... ..                                 |.|.......  |.                 | ...  .|.| ..||.|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RL------RGESCLVHCLAGVSRSVTLVIAYIMTVTD--------FGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|       .|. .|||| |||.|. |...||.| .          . ...|....|. |..| .| .. |.|.|....
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 26-159 4.6e-23 77.4 In-house 106-305 (317) alignment 
Range on Protein: 26-159
Range on HMM: 106-305/317.0
LSKNKVTHILSVHDSARP----------------------------MLEGVKYLCIPAADS----------------PSQNLTRHFKESIKFIHECRLR-
. ...||.|... ..  .                             |.|.......  |.                | ...  .... ..|....|   
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---GESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK-------------HEVHQYRQWLKEEYGESPL
   |. .|||| |||.|. |...||.|     .  .. .|.|....|. |..| .. .. |.| ...              . .. . ..| . ..... 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk
subfamily_DSP23_pd Subfamily DSP23 26-126 2.5e-08 28.7 In-house 27-129 (148) alignment 
Range on Protein: 26-126
Range on HMM: 27-129/148.0
LSKNKVTHILSVHDSARPMLEGVK---YLCIPAAD--SPSQNltrHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRA
|  . | ...|. . .||  | .    .  .   |   |. .     .| .. ..|   ..|.  |||| |  |. |..  |..   ..   .|.  || 
lldlgvrylvslteegrphveatpnltlvrlriddyhppale...qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

GRSCAN
 |  . 
lrpgsv
subfamily_CDKN3_pd Subfamily CDKN3 26-124 1.9e-06 21.6 In-house 83-176 (202) alignment 
Range on Protein: 26-124
Range on HMM: 83-176/202.0
LSKNKVTHILSVHDSARPMlegVKYLCIPAADSPSQNLTRHFKESIKfihECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTD-FGWEDALHTVRAGRSC
||| .| ..|  . .|  .   |..  |..   |.     .. | ..    .   .   ||||  |. ||  ..   .. . | . ..||.  .|  .  
lskyrvrrlldlyqqagli...vhhypiadglvpdiasclkileelr...inlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgs
0039614 (Phosphotyrosine protein) phosphatases II 27-149 2.1e-22 75.4 In-house 122-295 (297) alignment 
Range on Protein: 27-149
Range on HMM: 122-295/297.0
SKNKVTHIL---------------------------------------------SVHDSARPMLEGVKYLCIPaaDSPSQNLTRHFKESIKFIHECRL--
 ...||.|.                                              ....   ..  . |...|  |    ...... | .....|..   
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrealael

-RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQW
 .|. .|||| |||.|. |...||.|     .  .. ...|....|  |..| .. .. |.|...... . .....
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkltl
0043336 (Phosphotyrosine protein) phosphatases II 28-140 2.2e-16 55.6 In-house 110-274 (278) alignment 
Range on Protein: 28-140
Range on HMM: 110-274/278.0
KNKVTHILSV------------------------------------------------HDSARPMLEGVKYLCIPAADSPSqNLTRHFKESIKFIHECRL
...||.|...                                                 |.   .  .. ||..|  . |. .|. ...   .... .. 
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrealed

RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
...  |||| |||.|. |....|..     .   .  |.|....|  | .| ..  . |.| |...
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0046845 (Phosphotyrosine protein) phosphatases II 37-129 2.5e-11 38.9 In-house 156-260 (284) alignment 
Range on Protein: 37-129
Range on HMM: 156-260/284.0
VH---DSARPMLEGVKYLCIPAADSPS-QNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVT--------DFGWEDALHTVRAGRSC
..   ..   ..    |. .|  . |.  .   .| . .. ..| . .|.  .||| |||.|. |.......            .  ..|.. .|  | .
tnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg

ANPNV
.  ..
mvqtl
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 44-141 2.3e-21 69.4 In-house 43-140 (145) alignment 
Range on Protein: 44-141
Range on HMM: 43-140/145.0
MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
  | .. | | | |  | .|..|| |   ||   .  |   .|||.||||||||. .|..|   ..   .|   ||. |  | ||| | ..| ..|| 
ksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekq
0051299 (Phosphotyrosine protein) phosphatases II 44-129 4.9e-12 41.3 In-house 183-272 (288) alignment 
Range on Protein: 44-129
Range on HMM: 183-272/288.0
MLEGVKYLCIPAADSPSqnltrHFKESIKFIHECRLR----GESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNV
.     |. .|  . |.     .... ..|....|      |  ..||| |||.|. |.......     .   . ...|....|  | .. ...
tvthfhytnwpdhgvpd.....spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_PTPMT1_pd Subfamily PTPMT1 46-143 6.9e-17 56.4 In-house 72-169 (171) alignment 
Range on Protein: 46-143
Range on HMM: 72-169/171.0
EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
.||..| ..  |   .  . . .....||.. . .|..  ||| || .|| |||..|.|. . .  |.||..... |.  . .   ...|||.|.. .
lgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
subfamily_Laforin_pd Subfamily Laforin 46-114 2.4e-08 27.0 In-house 75-143 (183) alignment 
Range on Protein: 46-114
Range on HMM: 75-143/183.0
EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDA
||. |. .|  |  ...  . . ... ..|    .|    ||| ||| || ..|  ... | ..     
eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakv
subfamily_PTPDC1_pd Subfamily PTPDC1 46-143 1.3e-07 26.3 In-house 81-176 (182) alignment 
Range on Protein: 46-143
Range on HMM: 81-176/182.0
EGVKYLCIPAADSPSQNLTRHFkESIKFIHECRLRGeSCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
.|. .  .. .|  .. |.| . . .| .. .  .|    ||| ||  |   |. .|.. ....  |.|...||. |. .    .  . ..||... .
qgiyvynfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfli
0047943 (Phosphotyrosine protein) phosphatases II 47-137 9.8e-14 46.9 In-house 170-266 (273) alignment 
Range on Protein: 47-137
Range on HMM: 170-266/273.0
GVKYLCIPAADSP-SQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQE
 . |. .|  . | | .   .| | .. ..|   ...  .||| |||.|. |.......     .   .  ..|.. .|  | .. ... . |.| |
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
subfamily_RNGTT_pd Subfamily RNGTT 48-123 1.9e-08 28.2 In-house 81-155 (189) alignment 
Range on Protein: 48-123
Range on HMM: 81-155/189.0
VKYLCIPAADSPSQNLTRHFKESIKFIHEcRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRS
||  |    ..|... ...|.. ..  .. .   |   |||  |  |.  |...|.. ..|.. |.|... .  | 
vklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
0050432 (Phosphotyrosine protein) phosphatases II 49-129 1.4e-12 43.0 In-house 203-285 (308) alignment 
Range on Protein: 49-129
Range on HMM: 203-285/308.0
KYLCIPAADSPSQnlTRHFKESIKFIHECRlRGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNV
 |.  |  . |..  .... . ........ .|. ..||| |||.|. |.......     .   . ...|....|  | .. ...
hytnWpdhgvPps..peilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_DSP11_pd Subfamily DSP11 49-124 1.9e-07 25.2 In-house 81-159 (178) alignment 
Range on Protein: 49-124
Range on HMM: 81-159/178.0
KY--LCIPAADSPSQNLTRHFKESIK-FIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSC
||  | .|  . |...| ..||| .| |....   ..   |||  || |.  |.  |.. |...  |||...    |  
kylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGh
PTPc_DSPc_SM00012 54-105 1.8e-08 29.9 In-house 16-63 (105) alignment 
Range on Protein: 54-105
Range on HMM: 16-63/105.0
PAADSPSQNLTRHFKESIKFIHEcrlrGESCLVHCLAGVSRSVTLVIAYIMT
|   ..  .| |..|.. . . .    .....||| |||.|. |.| ..|. 
Peesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 60-104 3.8e-06 21.9 Pfam-A 145-193 (235) alignment 
Range on Protein: 60-104
Range on HMM: 145-193/235.0
SQNLTRHFKESIKFIHECRLRG----ESCLVHCLAGVSRSVTLVIAYIM
 ... .. |. ...|.... .     ....||| |||.|. |.| . |.
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
Y_phosphatase Protein-tyrosine phosphatase 60-104 3.8e-06 21.9 In-house 145-193 (235) alignment 
Range on Protein: 60-104
Range on HMM: 145-193/235.0
SQNLTRHFKESIKFIHECRLRG----ESCLVHCLAGVSRSVTLVIAYIM
 ... .. |. ...|.... .     ....||| |||.|. |.| . |.
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
subfamily_MSG5_pd Subfamily MSG5 63-139 3.1e-14 46.4 In-house 81-157 (165) alignment 
Range on Protein: 63-139
Range on HMM: 81-157/165.0
LTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFE
... . .  . ||  . ...  ||||  |.||| .|..||||   ..  .|| . ...     .|..|.  || |.|
ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe
0048567 (Phosphotyrosine protein) phosphatases II 67-122 8.6e-08 26.7 In-house 60-118 (157) alignment 
Range on Protein: 67-122
Range on HMM: 60-118/157.0
FKESIKFIHECRLRGESCLVHCLAGV---SRSVTLVIAYIMTVTDFGWEDALHTVRAGR
..   ||.. ..|.|    ||| ||    .|..||. .|.. . .|  |.|.. .|  |
ilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr