Gene DUSP22 in Homo sapiens

Synonym: JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, RP11-328C17.1, DUSP22

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP021_AA protein Get Run
HsapP021_AA_2-146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 3-141 2e-41 136.9 In-house 21-169 (178) alignment
Range on Protein: 3-141
Range on HMM: 21-169/178.0
NGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVH----------DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECR-LRGESCLVHCLAG
.....||||||.|.. .|.| |.| ....|||...           |   |. .|..||.||  |.. ..|..|| | ..||.|..  .|. .|||| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVTLVIAYIMTVTDFGWEDALHTVRAGRScANPNVGFQRQLQEFEKH
|.|| |||.||.| . .. .|.|.. ||. |. ..|| |..|||.|||..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr

0048179 (Phosphotyrosine protein) phosphatases II 3-140 1.1e-37 124.2 In-house 2-142 (144) alignment
Range on Protein: 3-140
Range on HMM: 2-142/144.0
NGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHD---SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLV
. ...||||||.|.. .|.| |.| |...|..... .    . .  ||..||..|  | .  .|. .. | ..||.|.. .|. .|||| |||.|. |||
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

IAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.||.| . .. .|.||. ||. |..|.|| |. |.|.|.||
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

0046846 (Phosphotyrosine protein) phosphatases II 3-141 5.2e-31 103.1 In-house 10-171 (176) alignment
Range on Protein: 3-141
Range on HMM: 10-171/176.0
NGMNKILPGLYIGNFK----------DARDAEQLSKNKVTHILSVHDS------------ARPMLEGVKYLCIPAADSPSQNLtRHFKESIKFIHECRLR
.... |...|..|..            | . |.| ....|..... .              . . .|..||..|  |    .| ... | ..||.|.. .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GESCLVHCLAGVSRSVTLVIAYIMTV-TDFGWEDALHTVRAGRS-CANPNVGFQRQLQEFEKH
|.  |||| ||..|. |||.||..    .. .|.||..||. |. .| .. .. |.|.|||..
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

subfamily_DSP15_pd Subfamily DSP15 4-154 1.4e-76 249.7 In-house 1-151 (151) alignment
Range on Protein: 4-154
Range on HMM: 1-151/151.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
|..|.|||||.|||.|..|.|.|.....||||||||.|...|. ..|.||.|.|.||..|...||||..|||.|||..|..|||||||||||||||.||.
giskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEY
||||...|.|||....| ||.||||.||.|||.|.||.....||..||||.
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlkeef

0048076 (Phosphotyrosine protein) phosphatases II 4-141 7.6e-38 124.7 In-house 3-141 (145) alignment
Range on Protein: 4-141
Range on HMM: 3-141/145.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSV-HDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
....||||||.|.. .|.| |.| ....|..|.. ..   .  .|..||..|  | . ..|.... | ..||.|.. .|. .|||| |||.|. |||.||
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
.|   .. .|.||. ||. |..|.||.|..|.|.|||..
lmlllgvsleealelvrsqrpgavpnpgqlrflyefele

subfamily_DSP14_pd Subfamily DSP14 4-142 2.4e-36 119.0 In-house 6-144 (157) alignment
Range on Protein: 4-142
Range on HMM: 6-144/157.0
GMNKILPGLYIGnFKDARDAEQLSKNKVTHILSVH-DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
....| | |...    |.. |.|.|.|.|.|. |  .   . |...... .|..|.|...|..|| | .. |.| . .|  .|||| |||||| .|..||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
.|       ..| ..|.. |.  .||||| .||...||. 
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl

0041856 (Phosphotyrosine protein) phosphatases II 4-149 2.6e-34 113.8 In-house 18-179 (182) alignment
Range on Protein: 4-149
Range on HMM: 18-179/182.0
GMNKILPGLYIGNFKD--------------ARDAEQLSKNKVTHILSVHDSA----RPMLEGVKYLCIPAADSPSQNltrhFKESIKFIHECRLRGESCL
....|...||.|....              |.. ..| ....|.|... .      . . .|..||..|  | .  .    . | ..||.|.. .|. .|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRS--CANPNVGFQRQLQEFEKHEVHQYRQW
||| |||.|. |||.||.| . ....|.|...||  |.  . .|| .| .||...|.... ..|..
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk

0049772 (Phosphotyrosine protein) phosphatases II 4-160 1.3e-32 109.2 In-house 125-293 (314) alignment
Range on Protein: 4-160
Range on HMM: 125-293/314.0
GM---------------------NKILPGLYigNFKDARDAEQLSknkvthilSVH-DSARPMLEGVKYLCIPAADsPSQNLTRHFKESIKFIHECrLRG
.|                     . ||.|..  |. .|.| |.|         ... |  ..  .|.|||.||  | .|..|...|.| ..||.|.  .|
vmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkg

ESCLVHCLAGVSRSVT-LVIAYIMTVTDFGWEDALHTVRAGRScANPNVGFQRQLQEFEKHE--VHQYRQWLKEEYGESPLQ
.  |||| ||..|. | .|.||.|   .. .|.||. ||. |. .||| || .||...|...  ...| ..||..|.  ...
gpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkkfyeyleen

subfamily_DSP3_pd Subfamily DSP3 4-143 2.4e-31 102.6 In-house 10-158 (162) alignment
Range on Protein: 4-143
Range on HMM: 10-158/162.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSaR--------PMLE--GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLR-GESCLVHCLAGV
 .. . |.||.|. . |.| ..| |  .||.|   .. |         . .  ..||| ... |.|. .| ..|... |||.|   .     |||| .||
evdevypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCaNPNVGFQRQLQEFEKHEV
||| |||.||.| . ..   .|..|||. |.   || || .||.|.... .
sRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelk

subfamily_DSP8_pd Subfamily DSP8 4-141 8.7e-31 100.6 In-house 14-153 (159) alignment
Range on Protein: 4-141
Range on HMM: 14-153/159.0
GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSV--HDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIA
|...||. ||.|  ||. . | |||. ....| .  .. .  .|. .|.| .|  |. . .|   |..|..||  ..    ..|||.||| ||| |..||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|||   ... ..| . |.  |   .||. |. || |.||.
yimktlemsldeayrfvkekrptispnlnflgqLleyeke

subfamily_STYX_pd Subfamily STYX 4-146 2.7e-28 92.1 In-house 11-161 (166) alignment
Range on Protein: 4-146
Range on HMM: 11-161/166.0
GMNKILPGLYIGNFKDARDA--EQLSKNKVTHILSVHDSA-----RPML-EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRS
 |..|||||..| .  |  .  |.| |. .|||. . ..      .| . .  .|| .  ||.. .|. |.. .  .|| ..  .|   |||  ||.|||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

VTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQY
 .|||||||    . . .| . |.  | | ||| || .||.|.|   . ..
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakl

PTPc_motif_SM00404 5-140 5.2e-40 131.6 In-house 2-139 (140) alignment
Range on Protein: 5-140
Range on HMM: 2-139/140.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP--MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
...|||.||.|. ..| ....|.|...||...| .. .     .|...|.||  |. ...|...... ..||.... .|...|||| ||||||.||.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.|.   . ...|.. |.  |.. .||..| |||.|.||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_DSP12_pd Subfamily DSP12 5-143 4.3e-39 128.4 In-house 2-144 (155) alignment
Range on Protein: 5-143
Range on HMM: 2-144/155.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSA----RPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVI
...||||||.|. ... . |.|.. |.||.|||   .    ..    |... |...|.|.... .|. | ..||.|.. .... |||| ||||||||.||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
||.|  ...  |.||..|.. .. ..|| ||..||. |||  .
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc

subfamily_DSP10_pd Subfamily DSP10 5-141 1.2e-38 126.5 In-house 14-152 (159) alignment
Range on Protein: 5-141
Range on HMM: 14-152/159.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEG--VKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
. ..|| |..|. |||.| . | . ..|..| |  |   . |.  .||  ||. |. .||| ..|.|...||.| | .|.. |||| ||.|||.|.||||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
.|. ..   .|| . |.  |.   ||..|  || ||||.
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke

0043147 (Phosphotyrosine protein) phosphatases II 5-149 4.7e-38 126.0 In-house 19-167 (172) alignment
Range on Protein: 5-149
Range on HMM: 19-167/172.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHD----SARPMLEGVKYLCIPAADSPSQnLTRHFKESIKFIHE--CRLRGESCLVHCLAGVSRSVTL
......... ... .| . ..| ....|||... .        . .|..||..|  | . . |.... | ..||.|  .. .|. .|||| |||.|..||
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VIAYIMTvTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQW
|.||.|   .. .|.|...||. |..| .| ...|.|..|||. .......
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllllkdsl

0049260 (Phosphotyrosine protein) phosphatases II 5-140 6.3e-32 105.7 In-house 8-147 (152) alignment
Range on Protein: 5-140
Range on HMM: 8-147/152.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSAR----PMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHE-CRLRGESCLVHCLAGVSRSVTLV
..........|.   | . ..| ....|.|... .        . .. .||..|  |.. ..|. .... ..||.. .. .|. .|||| |||.|. |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYIMTvTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.||.|   .. .|.|.  ||. |..|.|| |. |.|.||||
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek

0045098 (Phosphotyrosine protein) phosphatases II 5-145 6.5e-31 103.2 In-house 22-274 (278) alignment
Range on Protein: 5-145
Range on HMM: 22-274/278.0
MNKILPGLYIGNFK-----------------------------------------DARDAEQLSKNKVTHILSV--------------------------
...|.|.||.||..                                          | . ..| ....|.|...                          
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------HDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRL--------------RGESCLVHCLAGVSRSV
                           .|     .. ..||..|  ..||......| | ..||.|..               .|. .|||| |||.|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TLVIAYIMTVT---DFGWEDALHTVRAGRSC-ANPNVGFQRQLQEFEKHEVHQ
|||.||.|       . ...|....|  | . | .| ...|.| ||. . ...
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0037934 (Phosphotyrosine protein) phosphatases II 5-141 3.2e-29 97.6 In-house 39-240 (243) alignment
Range on Protein: 5-141
Range on HMM: 39-240/243.0
MNKILPGLYIGNF--------KDARDAEQLSKNKVTHILSVHD----------------------------------------------SARPMLEGVKY
. ...|.|.....        ..| . . | ....|.|... .                                                 . .....|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LCIPAAD----SPSQNLTRHFKESIKFIHE-----CRLRGESCLVHCLAGVSRSVTLVIAYIMTVT-DFGWEDALHTVRAGRSC-ANPNVGFQRQLQEFE
...|  |    .  ..| ....| ..||.|     .. .|. .|||| |||.|. ||..||.|    ....|.|....|. |.. | .. .. |.|.|..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

KH
..
le

0036282 (Phosphotyrosine protein) phosphatases II 5-140 8e-27 89.4 In-house 12-167 (174) alignment
Range on Protein: 5-140
Range on HMM: 12-167/174.0
MNKILPGLYIGNFKDArDAEQLSKNKVTHILSVHDSARP----------------MLEGVKYLCIPAADSPSQNLTRhFKESIKFIHECRLR--GESCLV
.. |.|.|..|..  | . |.| ....|..... ..  .                  .|..||..|  |    .|.  . | .||..|....  |  .||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCLAGVSRSVTLVIAYIMTVTDF-GWEDALHTVRAGR---SCANPNVGFQRQLQEFEK
|| |||.|. |||.||.| .  . . .|||..||. |   ... .. .. |.|..|||
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

0051082 (Phosphotyrosine protein) phosphatases II 5-139 4.5e-22 73.7 In-house 8-150 (151) alignment
Range on Protein: 5-139
Range on HMM: 8-150/151.0
MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSA-------RPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLR-GESCLVHCLAGVSRSV
.. . .|||....  |.. |.| ......|... .         .   .|...|.||  | | ..|  .|.. ..|.....   .  .|||| ||..|. 
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TLVIAYIMTvTDFGWEDALHTVRAGRS-CANPNVGFQRQLQEFE
|||..|.|   .. .|.||. .|. |  . .|| .|. ||....
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall

0036941 (Phosphotyrosine protein) phosphatases II 5-143 7.3e-19 63.6 In-house 19-277 (297) alignment
Range on Protein: 5-143
Range on HMM: 19-277/297.0
MNKILPGLYIGNFKDARDAEQLSKN----------------------------------------------------------KVTHILSVHDSARPM--
. ..|| |..|... |.  | |.||                                                          .||.|... .       
feellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

------------------------------LEGVKYLC----------------IPAADSPSQNLTRHFKESIKFIHECRL------RGESCLVHCLAGV
                              |.....                  .   . |  ..  .... ..||...|       .|.  |||| |||
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSVTLVIAYIM--------TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
.|| |...|..|        .   .   .|....|  | .| ..... |.| |.. . .
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_DSP19_pd Subfamily DSP19 6-141 1.7e-39 129.6 In-house 13-149 (152) alignment
Range on Protein: 6-141
Range on HMM: 13-149/152.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVH-DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
 .. | ||.|    | | |.|...|.||||.|  .  .   . ..||.|.  | | ..|....||...||.| |      |||| ||||||...||||.|
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
. ..   |.||..||. | |..|| ||..||.|.|..
kkeelsleealelvrearpcikPneGFikqLkeyeae

subfamily_DSP1_pd Subfamily DSP1 6-145 3.8e-36 118.6 In-house 19-159 (163) alignment
Range on Protein: 6-145
Range on HMM: 19-159/163.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEG-VKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
.|||. ||.|  ..| . |.|.....|.|| |  .   . |   .| ...  |||..... .|.| |.||.|..  .   |.|| ||.||| ||..||.|
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQ
. . .  |.| . |.  ||. .||.||..|| ..||.. ..
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle

subfamily_Slingshot_pd Subfamily Slingshot 6-139 8.1e-30 97.4 In-house 20-154 (169) alignment
Range on Protein: 6-139
Range on HMM: 20-154/169.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLE-GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
 ||   .|.|   .| . |.|..|.|..|| |      . .  ..|| |   |.....| ....|. |||.... .| ..||||  ||||| . |||| |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFE
   ..  |.||. |.  ||...|| || .||.|.|
keyglsleealeyvkerrsvikPnkgflkqleeye

0042113 (Phosphotyrosine protein) phosphatases II 6-141 2.5e-25 84.8 In-house 48-241 (245) alignment
Range on Protein: 6-141
Range on HMM: 48-241/245.0
NKILPGLYIGNFKDARDAE----QLSKNKVTHILSVHD-----------------------------------------------SARPMLEGVKYLCIP
 .| |.......  . . |    .| ....|.|... .                                                  . .|.. |...|
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

AADSPSQNLTRHFKESIKFIHECRL--RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
  | .  .|.... . ..|.....   ... .|||| |||.|. |...||.|     .  .. .|.|.. .|  |..| .. .. |.|.|....
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0051429 (Phosphotyrosine protein) phosphatases II 6-155 1.6e-22 75.9 In-house 17-248 (272) alignment
Range on Protein: 6-155
Range on HMM: 17-248/272.0
NKILPG-LYIGNFK---DARDAEQLSKNKVTHILSVHDSA-------RPMLEGVKYLCIPAADSPSQNLTRHF---------------------------
....|| || ...    .|.| ..| ......|... .          . ..|..||..|  |.  .  . ..                           
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------KESIKFIHECRLrGESCLVHCLAGVSRSVTLVIAYIMTvTDFG--------------WEDALHTVRAGRSCANPNVGFQ
                     .. ........  |. .|||| ||..|. |.| ....   ...              .|.|.. .|| | .|... .. 
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

RQLQEFEKHEV-----------HQYRQWLKEEYG
..|.|.... .           ... ....||||
lflyeallellrsllsvraeyllaaldaideeyG

0038934 (Phosphotyrosine protein) phosphatases II 6-142 6.6e-21 70.3 In-house 32-176 (194) alignment
Range on Protein: 6-142
Range on HMM: 32-176/194.0
NKILPGLYIGNFKDARDAEQLSKNKVTHILSVH------DSARPMLEGVKYLCIPAAD---SPSQNLTRHFKESIKFIHEcRLRGESCLVHCLAGVSRSV
.| ...||  ...|  .  .| . |........      |  . .  |..|| .|  |   .||......| . ...... .  |. ..||| ||..|. 
dkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtG

TLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
|||.||.. . ..  |.|....|  |  | ||... ..|... |. 
tlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel

subfamily_DSP6_pd Subfamily DSP6 7-141 3.8e-39 127.7 In-house 16-153 (158) alignment
Range on Protein: 7-141
Range on HMM: 16-153/158.0
KILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP---MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
.||| ||.|. ||| . | |.| |. ..| |           . .||| ||. |  ||||...| |.|.|| | | . ...|||||||.|||||...||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|  . .  .|| . |.. .|   ||  |  || .||..
mkklalslndaydlvkkrksnisPnfnfmgqlldfers

subfamily_LRR-DSP_pd Subfamily LRR-DSP 7-141 1.4e-32 106.8 In-house 122-257 (263) alignment
Range on Protein: 7-141
Range on HMM: 122-257/263.0
KILPGLYIGNFKDARDAEQLSKNKVTHI-LSVHDSARPMLEGVKYLCI-PAADSPSQNLTRHFKESIKFIHECRLRGeSCLVHCLAGVSRSVTLVIAYIM
.|...|..|  . | ..  | .. |||| |.| |      .  ||| |  . | .  .. .||.|   ||.| | .|   |||| |||||| ||||.|.|
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
    . ...||  |  .|.  .|| ||. ||. .||.
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk

PTEN_1 7-142 8e-31 102.4 In-house 43-191 (196) alignment
Range on Protein: 7-142
Range on HMM: 43-191/196.0
KILPGLYIGNFKDA-RDAEQLSKNKVTHILSVHDSARP----------MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRL--RGESCLVHCLAGVS
.| .|||.|. ||. .| ..| ....|..... .              . .||.|| .|  | . ..| ..|..  .||. ...  .|. .|||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
||.|.|.|| |    .  ..||  ||. |....|| ..|..|.|...  
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael

0040439 (Phosphotyrosine protein) phosphatases II 8-141 3.2e-25 84.6 In-house 32-244 (249) alignment
Range on Protein: 8-141
Range on HMM: 32-244/249.0
ILPGLYIGNFKDARDAE------------------------QLSKNKVTHILSVHDSAR-----------------------------------------
|||||. ... .|   .                        .| ....|.|... .  .                                         
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---PMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRL------RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPN
      | ...|.|.  | | ...  .|.. ..||...|       .|. .|||| |||.|. |...||.|     .  ..  |.|....|  |..| .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

VGFQRQLQEFEKH
 .. |.|.|....
peqyrflyealle

subfamily_STYXL1_pd Subfamily STYXL1 8-142 7.4e-23 74.5 In-house 14-153 (157) alignment
Range on Protein: 8-142
Range on HMM: 14-153/157.0
ILPG-LYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKY----LCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
.||| ||.||.|.| . .     ||   . |   | ....||.     | |.  |..  .|  ..|| ..||.. . .||  ||    |.|||....|||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
.|   ..  ..|.. ..  ..  .|| .|  ||.|.||. 
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 9-141 6.9e-21 68.2 In-house 7-151 (154) alignment
Range on Protein: 9-141
Range on HMM: 7-151/154.0
LPGLYIGNFKDARDAEQLSKNKVTHILSV-HDSARPMLE-------G--VKYLCIPAADSPSQNLTRHFKESIKFIHECR--LRGESCLVHCLAGVSRSV
   |||. |. | .  .| ......|| |   .   . .       |  ..|| .   | . ........ . .||..    .. .  |||. .||||| 
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
.|.|.|.|      .  ||  ..  |   .|| || .||. |||.
allisylmdklkislslalellkdsryiikPnqGflkqleifeke

DSPc Dual specificity phosphatase, catalytic domain 12-140 6e-36 118.2 Pfam-A 1-132 (133) alignment
Range on Protein: 12-140
Range on HMM: 1-132/133.0
LYIGNFKDARdAEQLSKNKVTHILSVHDSARP----MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVT
||.|. ..|   ..|.|...|....| .. .       .  .||.||  |. .........|...||.... .|...|||| ||.||| ||.|||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 .  ..|.. |.  ||. .||.||.||| |.|.
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 12-140 6e-36 118.2 In-house 1-132 (133) alignment
Range on Protein: 12-140
Range on HMM: 1-132/133.0
LYIGNFKDARdAEQLSKNKVTHILSVHDSARP----MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVT
||.|. ..|   ..|.|...|....| .. .       .  .||.||  |. .........|...||.... .|...|||| ||.||| ||.|||.|.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 .  ..|.. |.  ||. .||.||.||| |.|.
nlslneAyefvkerrskispnagflrqLleyer

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-142 9e-27 87.4 In-house 15-147 (148) alignment
Range on Protein: 12-142
Range on HMM: 15-147/148.0
LYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLE--GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDF
|..|. | | |.|.| .  ||.| .   . . .|.  |..|| .. .| | ..|   |.. |.|... . .|. .|||.  |||||  |......   . 
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

GWEDALHTVRAGRSCANPNVGFQRQLQEFEKHE
  ..||  |.  |   .|| || .||.|.|. |
slkealalvkskrryvdpnlgfLkqLaeleqae

subfamily_MKPLT_pd Subfamily MKPLT 12-140 2.5e-24 79.6 In-house 29-158 (164) alignment
Range on Protein: 12-140
Range on HMM: 29-158/164.0
LYIGNFKDARDAEQLSKNKVTHILSVHDS-ARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFG
|| || |.|.... | . |.|||. |    .    . |.|| .   | . ..|. ...   ||. .    |   ||||  |.||| .  .|....   . 
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

WEDALHTVRAGRSCANPNVGFQRQLQEFEK
 ..| . ..  ||...|| || .|| .||.
lkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 12-140 2.5e-24 79.6 In-house 29-158 (164) alignment
Range on Protein: 12-140
Range on HMM: 29-158/164.0
LYIGNFKDARDAEQLSKNKVTHILSVHDS-ARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFG
|| || |.|.... | . |.|||. |    .    . |.|| .   | . ..|. ...   ||. .    |   ||||  |.||| .  .|....   . 
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

WEDALHTVRAGRSCANPNVGFQRQLQEFEK
 ..| . ..  ||...|| || .|| .||.
lkeayeylkerrsivapnrGflkqlakfee

0045450 (Phosphotyrosine protein) phosphatases II 24-141 6.5e-26 87.2 In-house 125-302 (307) alignment
Range on Protein: 24-141
Range on HMM: 125-302/307.0
EQLSKNKVTHILSVHDSARP-----------------------------MLEGVKYLCIPAADS-----------------PSQNLTRHFKESIKFIHEC
..| ...||.|... ..                                 |.|.......  |.                 | ...  .|.| ..||.|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RL------RGESCLVHCLAGVSRSVTLVIAYIMTVTD--------FGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|       .|. .|||| |||.|. |...||.| .          . ...|....|. |..| .| .. |.|.|....
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 26-159 4.6e-23 77.4 In-house 106-305 (317) alignment
Range on Protein: 26-159
Range on HMM: 106-305/317.0
LSKNKVTHILSVHDSARP----------------------------MLEGVKYLCIPAADS----------------PSQNLTRHFKESIKFIHECRLR-
. ...||.|... ..  .                             |.|.......  |.                | ...  .... ..|....|   
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---GESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK-------------HEVHQYRQWLKEEYGESPL
   |. .|||| |||.|. |...||.|     .  .. .|.|....|. |..| .. .. |.| ...              . .. . ..| . ..... 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk





subfamily_DSP23_pd Subfamily DSP23 26-126 2.5e-08 28.7 In-house 27-129 (148) alignment
Range on Protein: 26-126
Range on HMM: 27-129/148.0
LSKNKVTHILSVHDSARPMLEGVK---YLCIPAAD--SPSQNltrHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRA
|  . | ...|. . .||  | .    .  .   |   |. .     .| .. ..|   ..|.  |||| |  |. |..  |..   ..   .|.  || 
lldlgvrylvslteegrphveatpnltlvrlriddyhppale...qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

GRSCAN
 |  . 
lrpgsv

subfamily_CDKN3_pd Subfamily CDKN3 26-124 1.9e-06 21.6 In-house 83-176 (202) alignment
Range on Protein: 26-124
Range on HMM: 83-176/202.0
LSKNKVTHILSVHDSARPMlegVKYLCIPAADSPSQNLTRHFKESIKfihECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTD-FGWEDALHTVRAGRSC
||| .| ..|  . .|  .   |..  |..   |.     .. | ..    .   .   ||||  |. ||  ..   .. . | . ..||.  .|  .  
lskyrvrrlldlyqqagli...vhhypiadglvpdiasclkileelr...inlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgs





0039614 (Phosphotyrosine protein) phosphatases II 27-149 2.1e-22 75.4 In-house 122-295 (297) alignment
Range on Protein: 27-149
Range on HMM: 122-295/297.0
SKNKVTHIL---------------------------------------------SVHDSARPMLEGVKYLCIPaaDSPSQNLTRHFKESIKFIHECRL--
 ...||.|.                                              ....   ..  . |...|  |    ...... | .....|..   
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrealael

-RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQW
 .|. .|||| |||.|. |...||.|     .  .. ...|....|  |..| .. .. |.|...... . .....
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkltl

0043336 (Phosphotyrosine protein) phosphatases II 28-140 2.2e-16 55.6 In-house 110-274 (278) alignment
Range on Protein: 28-140
Range on HMM: 110-274/278.0
KNKVTHILSV------------------------------------------------HDSARPMLEGVKYLCIPAADSPSqNLTRHFKESIKFIHECRL
...||.|...                                                 |.   .  .. ||..|  . |. .|. ...   .... .. 
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrealed

RGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
...  |||| |||.|. |....|..     .   .  |.|....|  | .| ..  . |.| |...
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0046845 (Phosphotyrosine protein) phosphatases II 37-129 2.5e-11 38.9 In-house 156-260 (284) alignment
Range on Protein: 37-129
Range on HMM: 156-260/284.0
VH---DSARPMLEGVKYLCIPAADSPS-QNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVT--------DFGWEDALHTVRAGRSC
..   ..   ..    |. .|  . |.  .   .| . .. ..| . .|.  .||| |||.|. |.......            .  ..|.. .|  | .
tnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg

ANPNV
.  ..
mvqtl

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 44-141 2.3e-21 69.4 In-house 43-140 (145) alignment
Range on Protein: 44-141
Range on HMM: 43-140/145.0
MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
  | .. | | | |  | .|..|| |   ||   .  |   .|||.||||||||. .|..|   ..   .|   ||. |  | ||| | ..| ..|| 
ksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekq

0051299 (Phosphotyrosine protein) phosphatases II 44-129 4.9e-12 41.3 In-house 183-272 (288) alignment
Range on Protein: 44-129
Range on HMM: 183-272/288.0
MLEGVKYLCIPAADSPSqnltrHFKESIKFIHECRLR----GESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNV
.     |. .|  . |.     .... ..|....|      |  ..||| |||.|. |.......     .   . ...|....|  | .. ...
tvthfhytnwpdhgvpd.....spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

subfamily_PTPMT1_pd Subfamily PTPMT1 46-143 6.9e-17 56.4 In-house 72-169 (171) alignment
Range on Protein: 46-143
Range on HMM: 72-169/171.0
EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
.||..| ..  |   .  . . .....||.. . .|..  ||| || .|| |||..|.|. . .  |.||..... |.  . .   ...|||.|.. .
lgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll

subfamily_Laforin_pd Subfamily Laforin 46-114 2.4e-08 27.0 In-house 75-143 (183) alignment
Range on Protein: 46-114
Range on HMM: 75-143/183.0
EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDA
||. |. .|  |  ...  . . ... ..|    .|    ||| ||| || ..|  ... | ..     
eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakv

subfamily_PTPDC1_pd Subfamily PTPDC1 46-143 1.3e-07 26.3 In-house 81-176 (182) alignment
Range on Protein: 46-143
Range on HMM: 81-176/182.0
EGVKYLCIPAADSPSQNLTRHFkESIKFIHECRLRGeSCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEV
.|. .  .. .|  .. |.| . . .| .. .  .|    ||| ||  |   |. .|.. ....  |.|...||. |. .    .  . ..||... .
qgiyvynfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfli

0047943 (Phosphotyrosine protein) phosphatases II 47-137 9.8e-14 46.9 In-house 170-266 (273) alignment
Range on Protein: 47-137
Range on HMM: 170-266/273.0
GVKYLCIPAADSP-SQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQE
 . |. .|  . | | .   .| | .. ..|   ...  .||| |||.|. |.......     .   .  ..|.. .|  | .. ... . |.| |
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye

subfamily_RNGTT_pd Subfamily RNGTT 48-123 1.9e-08 28.2 In-house 81-155 (189) alignment
Range on Protein: 48-123
Range on HMM: 81-155/189.0
VKYLCIPAADSPSQNLTRHFKESIKFIHEcRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRS
||  |    ..|... ...|.. ..  .. .   |   |||  |  |.  |...|.. ..|.. |.|... .  | 
vklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp

0050432 (Phosphotyrosine protein) phosphatases II 49-129 1.4e-12 43.0 In-house 203-285 (308) alignment
Range on Protein: 49-129
Range on HMM: 203-285/308.0
KYLCIPAADSPSQnlTRHFKESIKFIHECRlRGESCLVHCLAGVSRSVTLVIAYIM-----TVTDFGWEDALHTVRAGRSCANPNV
 |.  |  . |..  .... . ........ .|. ..||| |||.|. |.......     .   . ...|....|  | .. ...
hytnWpdhgvPps..peilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_DSP11_pd Subfamily DSP11 49-124 1.9e-07 25.2 In-house 81-159 (178) alignment
Range on Protein: 49-124
Range on HMM: 81-159/178.0
KY--LCIPAADSPSQNLTRHFKESIK-FIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSC
||  | .|  . |...| ..||| .| |....   ..   |||  || |.  |.  |.. |...  |||...    |  
kylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGh

PTPc_DSPc_SM00012 54-105 1.8e-08 29.9 In-house 16-63 (105) alignment
Range on Protein: 54-105
Range on HMM: 16-63/105.0
PAADSPSQNLTRHFKESIKFIHEcrlrGESCLVHCLAGVSRSVTLVIAYIMT
|   ..  .| |..|.. . . .    .....||| |||.|. |.| ..|. 
Peesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldill

Y_phosphatase Protein-tyrosine phosphatase 60-104 3.8e-06 21.9 Pfam-A 145-193 (235) alignment
Range on Protein: 60-104
Range on HMM: 145-193/235.0
SQNLTRHFKESIKFIHECRLRG----ESCLVHCLAGVSRSVTLVIAYIM
 ... .. |. ...|.... .     ....||| |||.|. |.| . |.
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

Y_phosphatase Protein-tyrosine phosphatase 60-104 3.8e-06 21.9 In-house 145-193 (235) alignment
Range on Protein: 60-104
Range on HMM: 145-193/235.0
SQNLTRHFKESIKFIHECRLRG----ESCLVHCLAGVSRSVTLVIAYIM
 ... .. |. ...|.... .     ....||| |||.|. |.| . |.
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

subfamily_MSG5_pd Subfamily MSG5 63-139 3.1e-14 46.4 In-house 81-157 (165) alignment
Range on Protein: 63-139
Range on HMM: 81-157/165.0
LTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFE
... . .  . ||  . ...  ||||  |.||| .|..||||   ..  .|| . ...     .|..|.  || |.|
ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe

0048567 (Phosphotyrosine protein) phosphatases II 67-122 8.6e-08 26.7 In-house 60-118 (157) alignment
Range on Protein: 67-122
Range on HMM: 60-118/157.0
FKESIKFIHECRLRGESCLVHCLAGV---SRSVTLVIAYIMTVTDFGWEDALHTVRAGR
..   ||.. ..|.|    ||| ||    .|..||. .|.. . .|  |.|.. .|  |
ilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr