Gene DUSP13 in Homo sapiens

Synonym: BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, RP11-487I5.6, DUSP13

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP025_AA protein Get Run
HsapP025_AA_262-411 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 239-404 1.4e-28 95.1 In-house 14-185 (196) alignment 
Range on Protein: 239-404
Range on HMM: 14-185/196.0
ASPYQPPTLASLQRLLWVRQ-AATLNHIDEVWPSLFLGDAYAA-RDKSKLIQLGITHVVNAAAGKFQ--VDTGAKFYRGMSLEYYGIEADDNPFFDLSVY
| | ....|..  . ... . | ... ..|....|..| .  . .|.  | . |||.||| . ..    ..   .... . .||. .. .| .  .||  
alptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslsel

FLPVARYIRAALSVP-QGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQ
|  ... | ..|| | .. |||||. |..||.|.| |.|| ....|  ||.. |...| ...|||.....|.
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
subfamily_PTPMT1_pd Subfamily PTPMT1 249-394 6.6e-11 37.0 In-house 4-151 (171) alignment 
Range on Protein: 249-394
Range on HMM: 4-151/171.0
SLQRLLWVRQAATLNHIDEVWPSLFLGDAYAARDKSKLI-QLGITHVVNAaAGKFQVDT---GAKFYRGMSLEYYGIEADDNP-FFDLSvYFLPVARYIR
.| . . |..|.. |..| .   ..||      ....|| .  .  ||.     ... .     . .. . .|.. ..  |     ||    .   ..|.
tllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvsl.neeyelkalansteewkklgveqlqlatvDfteapdle.klekgvefie

AALSVpQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHRNIC
   |  . || |||  | .|||||| ..||  |.... ||...... |.| 
kvask.gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii
0045098 (Phosphotyrosine protein) phosphatases II 253-410 2e-28 95.0 In-house 10-271 (278) alignment 
Range on Protein: 253-410
Range on HMM: 10-271/278.0
LLWVRQAATLNHIDEVWPSLFLGDAY-----------------------------------------AARDKSKLIQLGITHVVNAAAGKF---------
||.  .   |....|..|.|.||...                                         .| .   | .||||..|...  .          
llefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

------------------------------------QVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSV-------------PQGRV
                                      ... . .    | |....  . | .... .|| . ..||.||..             ..|.|
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LVHCAMGVSRSATLVLAFLMICE---NMTLVEAIQTVQAHRN--ICPNSGFLRQLQVLDNRL
|||| .||.|..|||.|.||..    ...| ||..... .|.  ...| ...|.|  .  .|
lVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0046846 (Phosphotyrosine protein) phosphatases II 255-405 2e-26 88.2 In-house 2-167 (176) alignment 
Range on Protein: 255-405
Range on HMM: 2-167/176.0
WVRQAATLNHIDEVWPSLFLGDAY----------AARDKSKLIQLGITHVVNAAAG----KFQVDTGAKFYRGMSLEYYGIEADDNPFFDLsVYFLPVAR
..|.    ...|.....|.||...           | .   | .||||.|||        ......  . .......|. .  .|.   ||  ..| . .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllelle

YIRAALSVPqGRVLVHCAMGVSRSATLVLAFLMIC-ENMTLVEAIQTVQAHR--NICPNSGFLRQLQV
.|| ||.   |.||||| .|..|..|||.|.|...  .... ||...|...|  .. .. ...|.|. 
firealkeg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflye
subfamily_DSP3_pd Subfamily DSP3 258-413 1.1e-72 236.9 In-house 4-160 (162) alignment 
Range on Protein: 258-413
Range on HMM: 4-160/162.0
QAATLNHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKF-QVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVH
.... ...|||.|.|..||...|.||||| .||||||.|||.|.| .|||||.||......|.|.|.||.| ||||.|| ..|..|..||| ..|.||||
erllskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvh

CAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRLGRE
|..|||||||||||.|||...|||||||.||...|.|.||.|||.||. ||..| |.
cvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkrk
0044763 (Phosphotyrosine protein) phosphatases II 259-410 5.2e-40 132.3 In-house 17-170 (178) alignment 
Range on Protein: 259-410
Range on HMM: 17-170/178.0
AATLNHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKF--QVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVH
..  ....|..| |.||....|.|.  | .|||||.|| .  .   .... ..........|. |  .|.. .||. .|| . ..|..||. ..|.||||
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRL
| .||.||.|||.|.||.. ...| |||. |...|.|.|| |.||||. .. ||
CsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrl
subfamily_DSP14_pd Subfamily DSP14 262-410 4.2e-35 115.0 In-house 4-144 (157) alignment 
Range on Protein: 262-410
Range on HMM: 4-144/157.0
LNHIDEVWPSLFLGdAYAARDKSKLIQLGITHVVNAAAgkfQVDTgaKFYRGMSleYYGIEADDNPFFDLSVYFLPVARYIRAAlSVPQGRVLVHCAMGV
|... .. |||||. ..||..|..| . .||...|..    .. .  . .....  .  . ..|||  .|. .| .|| .|... .  .|..||||..||
laalsqitpsLfls.gvaalskellkkkkitliinvtv...elpn..tklkdie..rvkvpveDnpeaklakhfdevadkieev.kkkggktlvhCvaGv

SRSATLVLAFLMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLDNRL
||||.|.||.||  |...| || ..|...|. |.||.|| .||. ....|
SRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
subfamily_DSP1_pd Subfamily DSP1 263-412 9e-33 107.6 In-house 16-158 (163) alignment 
Range on Protein: 263-412
Range on HMM: 16-158/163.0
NHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAgkfQVDtgaKFYRGmSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVS
. . .. . |.|| .. | ... | .||||...|...   ..|   ....   .||. .. .|.|  |.|..| .|  .| .. .  .|.||.||..|.|
dPvekildfLylGsetvasnleiLkslgitailnvsk...eld...nvfed.lfeYkklkleDspkadislvfeeviefidevkkk.nGkvlihCqaGis

RSATLVLAFLMICENMTLVEAIQTVQAHRNI-CPNSGFLRQLQVLDNRLGR
||.||.||.||  ....| || . |. .|.|  || || .||   ...|..
RsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_Slingshot_pd Subfamily Slingshot 263-407 2.2e-21 70.0 In-house 17-154 (169) alignment 
Range on Protein: 263-407
Range on HMM: 17-154/169.0
NHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAgkfQVDtgaKFYRGmSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSvPQGRVLVHCAMGVS
..  ...  ..||  . | .  .| . |.....| .    ..|   .|. . ..||. |   |..  ||  |.    ..|..| .  . .||||| ||||
dsaskifdhvylGsewnasnleelkengveyilnvtk...eid...nffpe.kfeylnirvydeeetdllkywnetykfiekakk.kgskvlvhckmGvs

RSATLVLAFLMICENMTLVEAIQTVQAHRNIC-PNSGFLRQLQVLD
|||. |.|. |   ...| ||.. |. .|..  ||.|||.||.. .
rsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeye
0041856 (Phosphotyrosine protein) phosphatases II 264-411 3.9e-31 103.4 In-house 18-173 (182) alignment 
Range on Protein: 264-411
Range on HMM: 18-173/182.0
HIDEVWPSLFLGDAYA--------------ARDKSKLIQLGITHVVNAAagkfQVDTGAKFYRGMSLEYYGIEADDNPFFDlsvyFLPVARYIRAALSvP
..|.....|.||. .|              |..   | .||||..||..     .   ....  . ..|. .  .|.. .|    .  . ..|...|. .
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.e

QGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHRN---ICPNSGFLRQLQVLDNRLG
.|.||||| .||.|..|||.|.||.. ...| ||...|. .|.   |.|| .|..||..|. .|.
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0048179 (Phosphotyrosine protein) phosphatases II 264-409 1.4e-30 101.3 In-house 3-143 (144) alignment 
Range on Protein: 264-409
Range on HMM: 3-143/144.0
HIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVDTGAKfyrgmSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSvPQGRVLVHCAMGVSR
...|..|.|.||. ..|.|   | .||||.|.| . .  . . .        ..|. .  .|.. .||. ..| . ..|..||. . |.||||| .||.|
npseilpglylgslptaldlellkklgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgR

SATLVLAFLMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLDNR
..|||.|.||......| ||.. |...|  ..|| |.||.|. ....
tgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP19_pd Subfamily DSP19 264-408 4.6e-30 99.0 In-house 11-148 (152) alignment 
Range on Protein: 264-408
Range on HMM: 11-148/152.0
HIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVdtgakFYrgMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPqGRVLVHCAMGVSR
.. || |.|.||   .| ||..| . .|||..| |.|  .|     |     ..|  ||  |.|  ||. |.  .  .|. |.|   |.|||||  ||||
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnv.....fp..kdftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvSR

SATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVLDN
||..|.|.||  |...| ||...|...| .|.||.||..||. ...
sasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyea
0043147 (Phosphotyrosine protein) phosphatases II 264-410 2.7e-28 94.2 In-house 18-160 (172) alignment 
Range on Protein: 264-410
Range on HMM: 18-160/172.0
HIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAagkfQVDTGAKFYRGMSLEYYGIEADDNPFFdLSVYFLPVARYIRA-ALSVPQGRVLVHCAMGVS
..|.... ..... . | .   | .|||||.||.     .  . ....  . ..|. .  .|.. . |. ..| . ..|.  ..  |.|.||||| .||.
ipdrfiatqgplrntladfwrmlkelgithivnlt....ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvg

RSATLVLAFLMIcENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLDNRL
|..|||.|.||. ....| ||...|...|. ...| ...|.|. ....|
Rtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0051082 (Phosphotyrosine protein) phosphatases II 264-406 1.3e-26 88.4 In-house 7-149 (151) alignment 
Range on Protein: 264-406
Range on HMM: 7-149/151.0
HIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVdTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSR
..  |.. |.....  |..   | .|||...||    .    . ..... ...|.. |  .|.|...|...|  |.......|. ..| ||||| .|..|
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgR

SATLVLAFLMIcENMTLVEAIQTVQAHR--NICPNSGFLRQLQVL
..|||...||. ....| ||.. ....|   ..|| .|| ||..|
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0036282 (Phosphotyrosine protein) phosphatases II 264-405 3.1e-25 84.3 In-house 11-164 (174) alignment 
Range on Protein: 264-405
Range on HMM: 11-164/174.0
HIDEVWPSLFLGDAYAArDKSKLIQLGITHVVNAAAGKFQV--------DTGAKFYRGMSLEYYGIEADDNPFFDLSVyFLPVARYIRAALSV-PQGRVL
.. ...| |..|.. .| .   | .||||.||.    |            .  .... . ..|. .  .|.  .|||. .| . .... |||  |.| ||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCAMGVSRSATLVLAFLMICENM-TLVEAIQTVQAHR----NICPNSGFLRQLQV
||| .||.|..|||.|.||..  . .||.|...|.. |    ..... ...|.|. 
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_STYX_pd Subfamily STYX 264-407 6.2e-19 61.7 In-house 11-154 (166) alignment 
Range on Protein: 264-407
Range on HMM: 11-154/166.0
HIDEVWPSLFLGdAYAARDKSKLIQL---GITHVVNAAAGKFQVDtgAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMG
...|. | ||||  |.|  |||| .|   ||||.|             |     .. |  ..  ||.  ..  |.  |  .|  .|.   |.||||   |
emqeilpglflg.pysaamksklevlkkhgithivcirqnieanl..ikpnfpdrfrylvldvadntveniirylptvkefiddslqk.ggkvlvhgnag

VSRSATLVLAFLMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLD
.||||.||.|..|    .   || . || .|  | ||.|| .||.. .
isrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0036941 (Phosphotyrosine protein) phosphatases II 264-406 1.4e-18 62.7 In-house 18-272 (297) alignment 
Range on Protein: 264-406
Range on HMM: 18-272/297.0
HIDEVWPSLFLGDAYAARDKSKLI----------------------------------------------------------QLGITHVVNAAAGK----
. .|..| |.||. ..|. .  |                                                           ....|..|.         
efeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

------FQVD-TGAKFYRGMSLEYYGIEA-----------------------------DDNPFFDLSVYFLPVARYIRAALSV-----PQGRVLVHCAMG
      .  .  . . | ...... ..|                               . | ...  .. .. ..|.....|     ..|.||||| .|
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

VSRSATLVLAFLM--------ICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVL
|.||.|...|.||        . ......||....  .| ..... ...|.|  .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
subfamily_DSP8_pd Subfamily DSP8 264-410 7.6e-15 48.8 In-house 14-154 (159) alignment 
Range on Protein: 264-410
Range on HMM: 14-154/159.0
HIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVDTgakfYRGMSleYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVSR
 . .. . |.||    . ... | .|||..|.||     ....     .     .  .   |.   .|. .|     .|  | |  .||||||.  | ||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpklee....lkesk..flrvPvkDkydekllpwfdksvefidkakse.ngrvlvhvlaGisr

SATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVLDNRL
|||...|..|   .|.| || . |. .|  | ||  || ||   ...|
satvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekel
0048076 (Phosphotyrosine protein) phosphatases II 265-408 1.5e-30 101.2 In-house 4-140 (145) alignment 
Range on Protein: 265-408
Range on HMM: 4-140/145.0
IDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAaagkfqvDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPqGRVLVHCAMGVSRS
..|..|.|.||. ..|.|   | .||||.|.|         .  ...  . ..|. .  .|.. .||. ..| . ..|..||. . |.||||| .||.|.
pseilpglylgslptaldlellkdlgittvlnl.......tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRt

ATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVLDN
.|||.|.||......| ||.. |...| ...|| |.||.|. .. 
gtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_DSP12_pd Subfamily DSP12 265-406 1.9e-28 93.8 In-house 2-139 (155) alignment 
Range on Protein: 265-406
Range on HMM: 2-139/155.0
IDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAagKFQVdTGAKFYRGMSLeYYGIEADDNPFFDLSVYFLPVARYIRAALsVPQGRVLVHCAMGVSRS
.... | |.||.. |. ....| .|.||||.  .  |...    |  .|    .  |...|.|  |.  ..  . ..|  ||   .| |||||..|||||
vsrilpglylggleavqeeellkelkithvlsvi..keel.pehklkkgkvs.tkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRS

ATLVLAFLMICENMTLVEAIQTVQA-HRNICPNSGFLRQLQVL
.|.|.|.||  |.. | .|...|.. ...|.|| |||.||.. 
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklf
subfamily_DSP10_pd Subfamily DSP10 265-412 7.5e-26 84.9 In-house 14-155 (159) alignment 
Range on Protein: 265-412
Range on HMM: 14-155/159.0
IDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAgkfqvDTGAKFYRgMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVSRS
. .| | ||||..  |.|.. | .|.||.|.| ..     ..  .|.   .|.|  |.. |.   .|. ||     .|  | .  . ||||||  |.|||
asqvlpfLflGsekdaadldaldrlnitavlnvtt.....svPnefee.ealkYkripvsDtskqnlkqyfeealefieearkk.gsrvLvhCqaGisrs

ATLVLAFLMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLDNRLGR
||.|.|.||   |..| .| . |.  |  | || .|. ||  ....| .
atvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_DSP15_pd Subfamily DSP15 265-407 2e-25 83.6 In-house 2-136 (151) alignment 
Range on Protein: 265-407
Range on HMM: 2-136/151.0
IDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAgkfqvdTGAKFYRGmsLEYYGIEADDNPFFDLSVYFLPVARYIRAAlSVPQGRVLVHCAMGVSRS
|..| | |.||.   ..|. .| .  |||...            |. .   .||  |.|.| |  .|| .|    ..| ..  . .. |||||..|||||
iskvlpglylgnfrdskdeelLkeknithilsvhd......nakkllkd..ieYkciaasDtpsaklskffkesvefihkc.RlkeenvlvhClaGvsRs

ATLVLAFLMICENMTLVEAIQTVQAHRNIC-PNSGFLRQLQVLD
.||| |.||   ..   .|.....|.| .  || || |||.. .
vtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye
PTPc_motif_SM00404 266-407 4.3e-29 96.2 In-house 3-138 (140) alignment 
Range on Protein: 266-407
Range on HMM: 3-138/140.0
DEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKF-QvdtgakfYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAAlSVPQGRVLVHCAMGVSRS
 .. | |.|| ...| .. .| .||||||.|..  .  .       .   . ..  |. |||   .|| |.  |...|..|    .|.|||||..|||||
srilphlylgskskaqnpallkklgithvinvteevslt.......kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRS

ATLVLAFLMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLD
|||..|.||  ....| ||.. |.  |. |.|| .|.|||. . 
atliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 266-408 9.6e-29 93.8 In-house 8-145 (148) alignment 
Range on Protein: 266-408
Range on HMM: 8-145/148.0
DEVWPS-LFLGDAYAARDKSKLIQLGITHVVNAAAgKFQVDTGAKfyrgmSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVSRS
 |.... ||||.   | | ..| .||.|..|||.. . .     .     ..||. .. ||.| .||| .| ... ..| | .   .|||||. ||||||
seikdafLFlGskksaadlealkalgvtrivnatk.erdnaldqr.....gieYlhvaldDkpkedlsaiFediiafvrkakde.GrrvLvhlqmGvsrs

ATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVLDN
. |.|..|.  ....| ||.. |.  |  . || |||.||. |..
salallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_LRR-DSP_pd Subfamily LRR-DSP 266-410 4.9e-24 78.8 In-house 121-258 (263) alignment 
Range on Protein: 266-410
Range on HMM: 121-258/263.0
DEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAgKFQvdtgaKFYRGmSLEYYGI-EADDNPFFDLSVYFLPVARYIRAALSvpQGRVLVHCAMGVSRS
||. . ||||   .| .|| | .||.||.. | | .|.      ..    . |. | ...| . .|.| .|  .  .|       .| |||||  |||||
deiidklflGgldsannksilkdlgvthillava.dfe.....PlfPk.lfkylsiddiedvdeadisqhfeetnafieeGrk..kGGvlvhcraGvsrs

ATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVLDNRL
.|||...||  ..... ||.  |. .| .| || ||. ||.  .. |
stlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0042113 (Phosphotyrosine protein) phosphatases II 266-404 6.4e-19 63.8 In-house 48-236 (245) alignment 
Range on Protein: 266-404
Range on HMM: 48-236/245.0
DEVWPSLFLGDAYAARDKS----KLIQLGITHVVNAAAGK---------------------------------------FQVD--TGAKFYRGMSLEYYG
....| ...... .. .       | .||||..|.                                            ..|      .   .. . |..
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

IEadDNPFFDLSVYFLPVARYIRAALS-VPQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHR-NICPNSGFLRQLQ
..  |..  ||. ..| . ...| ||.  ..|.||||| .||.|..|...|.||        ...| ||.. .. .| ..... ...|.|.
wp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0049260 (Phosphotyrosine protein) phosphatases II 267-405 1.4e-25 85.1 In-house 10-144 (152) alignment 
Range on Protein: 267-405
Range on HMM: 10-144/152.0
EVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVDTGAKFYRgmslEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSAT
|... ...|.  .| ..  | .||||..|.          . ..|     .|. .  .|..  ||| ..| . . |. ..  ..|.|||||  ||.|..|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

LVLAFLMIcENMTLVEAIQTVQAHRN-ICPNSGFLRQLQV
||.|.||.  ...| ||.. |...|. ..|| |.||.|. 
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_DSP6_pd Subfamily DSP6 267-411 8e-24 77.9 In-house 16-155 (158) alignment 
Range on Protein: 267-411
Range on HMM: 16-155/158.0
EVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAgkfqvDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVSRSAT
|. | |.|| | .| .   | .|.| .|.| .      .   ||    .|.|. | ..|.   .|. .|    ..|  | |  .  |||||  |.||| |
eilpllylGsakdasnlevlkklkikyvlnvts.....nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.kskvlvhClaGisrsvt

LVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQLQVLDNRLG
..||.||  ....| .| . |.... || ||  |. ||   ...|.
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
0040439 (Phosphotyrosine protein) phosphatases II 267-406 1.3e-21 72.8 In-house 31-241 (249) alignment 
Range on Protein: 267-406
Range on HMM: 31-241/249.0
EVWPSLFLGDAYAA------------------------RDKSKLIQLGITHVVNAAAGKFQ--------------------------VDTGAKF------
...|.|||.| . |                         .   | .||||..|..   .                            |.. ...      
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

----YRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSV-----PQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHR-NICP
    | | |.....|   | | .... .| .. ..|.|....     ..|.||||| .||.|..|...|.||        ...| ||..... .| ....
ltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NSGFLRQLQVL
| ...|.|. .
npeqyrflyea
0037934 (Phosphotyrosine protein) phosphatases II 267-404 1.8e-20 69.0 In-house 41-235 (243) alignment 
Range on Protein: 267-404
Range on HMM: 41-235/243.0
EVWPSLFLGDA--------YAARDKSKLIQLGITHVVNAAAGK----------------------------------------FQVDTGAKFYRGMSLEY
.|.| |.....        ..| .   | .||||..|.    .                                          .|..  .. .. . |
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

YGIEADDNPF-FDLSVYFLPVARYIRAA-----LSVPQGRVLVHCAMGVSRSATLVLAFLMICE-NMTLVEAIQTVQAHRN--ICPNSGFLRQLQ
...   . |  ..  . ||  .| .  .        ..|.||||| .||.|..||..|.||.   ...| ||.......|.  .... ...|.|.
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly
subfamily_STYXL1_pd Subfamily STYXL1 267-408 5.8e-14 45.6 In-house 13-151 (157) alignment 
Range on Protein: 267-408
Range on HMM: 13-151/157.0
EVWPS-LFLGDAYAARDKSKLIQLGITHVVNAAAGKFQvdtgakFYRGMSL--EYYGIEADDNPFFDLSVYFLPVARYIRAALSvPQGRVLVHCAMGVSR
|| |. |.||.   | ...    | .  .|| .    .      .. |..   .   |. .|..  ||   .  . ..|       .  |||    |.||
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk......liagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisr

SATLVLAFLMICENMTLVEAIQTVQA-HRNICPNSGFLRQLQVLDN
||....|.||  ...|| .| . ..  . |..|| .|. ||.  ..
saaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
0051429 (Phosphotyrosine protein) phosphatases II 270-404 7.7e-16 54.0 In-house 21-218 (272) alignment 
Range on Protein: 270-404
Range on HMM: 21-218/272.0
PS-LFLGDAY---AARDKSKLIQLGITHVVNAAAGKFQVDTG-AKFYRGMSLEYYGIEADDNPFFdlSVYF-----------------------------
|  |.....     |.|  .| .|||...|.      .   .  ..  |. . .. |. |. |.   ....                             
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsapti..lygalrvtllseellldyilrellltlllsage

-------------------LPVARYIRAALSvpQGRVLVHCAMGVSRSATLVLAFLMIcENMT--------------LVEAIQTVQAHR-NICPNSGFLR
                    .. . ... |.  .|.|||||. |..|..|.|...|.. ....              | ||.. ..|.| .. .. ....
arevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLQ
.|.
fly
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 271-408 1.9e-21 70.0 In-house 9-150 (154) alignment 
Range on Protein: 271-408
Range on HMM: 9-150/154.0
SLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVDT--GAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAAL-SVPQGRVLVHCAMGVSRSATL
 |...   || .| .| .  |....| . |   . |   .    |. .||  .|  |.. ||.   .  .  .|. |. .| ...||||.  ||||||.|
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VLAFLMICENMTLVEAIQTVQAHRNIC-PNSGFLRQLQVLDN
....||   ...| .|.. ..  | |. || |||.||.. . 
lisylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_MKPLT_pd Subfamily MKPLT 271-406 9.9e-21 67.9 In-house 28-156 (164) alignment 
Range on Protein: 271-406
Range on HMM: 28-156/164.0
SLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQvdtgaKFyrGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVSRSATLVLA
 |.||.|  |...  | .| |||.|| . .| .     .|   .|.||  .. .|..   || ..  .| ..  |.    ||||||| .|.|||..  .|
tlylGnakhatnekvlkdlkithivnvsqekkd.....af..pksveYlqvkvedesdeqlssfleraakfladaids.GGrvlvhcvqGksrsssvtva

FLMICENMTLVEAIQTVQAHRNI-CPNSGFLRQLQVL
||.  .  || || . ..  | |  || |||.||   
fLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 271-406 9.9e-21 67.9 In-house 28-156 (164) alignment 
Range on Protein: 271-406
Range on HMM: 28-156/164.0
SLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQvdtgaKFyrGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVpQGRVLVHCAMGVSRSATLVLA
 |.||.|  |...  | .| |||.|| . .| .     .|   .|.||  .. .|..   || ..  .| ..  |.    ||||||| .|.|||..  .|
tlylGnakhatnekvlkdlkithivnvsqekkd.....af..pksveYlqvkvedesdeqlssfleraakfladaids.GGrvlvhcvqGksrsssvtva

FLMICENMTLVEAIQTVQAHRNI-CPNSGFLRQLQVL
||.  .  || || . ..  | |  || |||.||   
fLikskgwtlkeayeylkerrsivapnrGflkqlakf
DSPc Dual specificity phosphatase, catalytic domain 272-407 8.9e-27 88.6 Pfam-A 1-131 (133) alignment 
Range on Protein: 272-407
Range on HMM: 1-131/133.0
LFLGDAYAARdKSKLIQLGITHVVNAAAGKFQVdtgaKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAAlSVPQGRVLVHCAMGVSRSATLVLAF
|.|| ...|  ...| .||||.|.|..  . .     ...   . || .|  .|.   ..| ..  . ..|..|    ...|||||..|.||||||..|.
lylgskstas.lalleklgitlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaY

LMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLD
||  .|..| ||.. |.  |. |.|| ||||||  ..
lmktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 272-407 8.9e-27 88.6 In-house 1-131 (133) alignment 
Range on Protein: 272-407
Range on HMM: 1-131/133.0
LFLGDAYAARdKSKLIQLGITHVVNAAAGKFQVdtgaKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAAlSVPQGRVLVHCAMGVSRSATLVLAF
|.|| ...|  ...| .||||.|.|..  . .     ...   . || .|  .|.   ..| ..  . ..|..|    ...|||||..|.||||||..|.
lylgskstas.lalleklgitlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaY

LMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLD
||  .|..| ||.. |.  |. |.|| ||||||  ..
lmktknlslneAyefvkerrskispnagflrqLleye
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 272-411 5.7e-23 74.6 In-house 6-142 (145) alignment 
Range on Protein: 272-411
Range on HMM: 6-142/145.0
LFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVdtgAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGrVLVHCAMGVSRSATLVLAF
|. | |  |.| . | .|||. .|| |||.      ..  .. |.|   | |.|   .||| .|  |. .|        | |.|||  ||||| |. .||
lyvgsalhandvptlqelgisrivnmaagslva...sqelksesieillitaedlesydlsqhfdevtdfidkgkeegag.vfvhcmagvsrsvtvsvaf

LMICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVLDNRLG
||   |||| || . |...|   .||  ||..|  |. .| 
lmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0049772 (Phosphotyrosine protein) phosphatases II 276-410 1.1e-26 89.8 In-house 156-273 (314) alignment 
Range on Protein: 276-410
Range on HMM: 156-273/314.0
DAYAARDKSKLIqlgithvvnaaagkfQVDTGAKFYRGMSLEYYGIEADDnPFFDLSVYFLPVARYIRAAlsVPQGRVLVHCAMGVSRSAT-LVLAFLMI
. . |.|   |                .. . .... .. ..|. |  .| . ..|. .|. . ..|..|   ..|.|||||..|..|..| .|.|.||.
neptaadlellk...............eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmk

CENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRL
. ...| ||.. |.. | |.|| ||..||. . ..|
llgvsleealedvrlkRpinpnpgfieqleqyefil
0045450 (Phosphotyrosine protein) phosphatases II 279-406 1.3e-20 69.8 In-house 104-299 (307) alignment 
Range on Protein: 279-406
Range on HMM: 104-299/307.0
AARDK----------------SKLIQLGITHVVNAA----------------------AGKFQVDTGAKFYrGMSLEYYGIEADDN--------------
   .|                  | ..|.|..|.                         |.|.| .  . .   .. .. .|  |.              
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhy

---PFFDLSVYFLPVARYIRAALSV-----PQGRVLVHCAMGVSRSATLVLAFLMICEN--------MTLVEAIQTVQAHR-NICPNSGFLRQLQVL
   | .... .| .. . |......     ..|.||||| .||.|..|...|.||..          ..| ||.......| ....| ...|.|. .
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 286-406 1.4e-17 59.5 In-house 106-271 (317) alignment 
Range on Protein: 286-406
Range on HMM: 106-271/317.0
LIQLGITHVVNA---------------------AAGKFQVDTGAKFYrGMSLEYYGIEADDN----------------PFFDLSVYFLPVARYIRAALSV
. ..|.|..|.                        |.|.| .   ..   . ... .|  |.                | ...  .. .. . ..|. ..
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

---PQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHRN-ICPNSGFLRQLQVL
   |.| ||||| .||.|..|...|.||       ..... ||.......|. .... ...|.|  .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0039614 (Phosphotyrosine protein) phosphatases II 286-405 1.3e-16 56.3 In-house 121-283 (297) alignment 
Range on Protein: 286-405
Range on HMM: 121-283/297.0
LIQLGITHVVNAAAGK---------FQVDTGakFYRGMSLEYYGI------------------------------EadDNPFFDLSVYFLPVARYIRAAL
. ..|.|..|.    .         .  ..|   | ... .. ..                                 |.   ... ..| . ...| ||
vweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvreal

SV--PQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHR-NICPNSGFLRQLQV
.   ..|.||||| .||.|..|...|.||        .... ||..... .| ..... ...|.|. 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd
subfamily_Laforin_pd Subfamily Laforin 305-391 2e-06 20.8 In-house 66-151 (183) alignment 
Range on Protein: 305-391
Range on HMM: 66-151/183.0
DTGAKFYRGMSLEYYGIEADDNPfFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHR
.|  |.|.   | |  .  .|    .  |  || | |.  ||     .| |||  || ||...|  ||.   . .|      . |.|
itlkklykeeglayiwlptedls.tesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
0038934 (Phosphotyrosine protein) phosphatases II 308-406 9e-17 56.8 In-house 72-172 (194) alignment 
Range on Protein: 308-406
Range on HMM: 72-172/194.0
AKFYRGMSLEYYGIEADD---NPFFDLSVYFLPVARYIRAAlsVPQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHR-NICPNSGFLRQL
.. . .. .||. .   |    | ...   || ..  . ..   |.| |.||| .|..|..||| |.|. . .|.. |||....  | .. || ..|..|
peefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleal

QVL
.. 
lkr
subfamily_CDC14_pd Subfamily CDC14 308-391 3.4e-06 21.1 In-house 221-304 (328) alignment 
Range on Protein: 308-391
Range on HMM: 221-304/328.0
AKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHR
.| |   . .  |..  |  | | |.    . .   ...   .| . |||  |. |  ||. ..||   ..|  |||  ..  |
kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
0043336 (Phosphotyrosine protein) phosphatases II 309-403 1.1e-13 46.7 In-house 171-269 (278) alignment 
Range on Protein: 309-403
Range on HMM: 171-269/278.0
KFYRGMSLEYYGIEADDNPFfdLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHR-NICPNSGFLRQ
. . .. . |.|.  .. |       .|   ...| ||. ..| |||||  ||.|..|.....|.        ...| ||..... .| .....  ..|.
esrtvthyhylgwpdhgvpe..slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

L
|
l
0048567 (Phosphotyrosine protein) phosphatases II 309-397 6.7e-09 30.3 In-house 32-121 (157) alignment 
Range on Protein: 309-397
Range on HMM: 32-121/157.0
KFYRGMSLEYYGIEADDNPF-FDLSVYFLPVARYIRAALSVPQGRVLVHCAMGV---SRSATLVLAFLMICENMTLVEAIQTVqahRNICPNS
 |     | |.   .|. |.  .. . |  ..  .   |.   ... ||| .|    .|.|||. ..|... ..|  |||. .   | . |.|
yFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiapl...rivrpgs
0051299 (Phosphotyrosine protein) phosphatases II 325-394 3.5e-11 38.5 In-house 194-268 (288) alignment 
Range on Protein: 325-394
Range on HMM: 194-268/288.0
DNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHRNIC
|. . |    .|   |..| ||. ..| |.|||  ||.|..|.....|.       . ... ||....  .|. .
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm
0047943 (Phosphotyrosine protein) phosphatases II 327-394 1.3e-10 36.7 In-house 180-254 (273) alignment 
Range on Protein: 327-394
Range on HMM: 180-254/273.0
PFFDLSVYFLPVARYIRAALSV--PQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHRNIC
   .   ..|   ...| ||.    .| |.|||  ||.|..|.....|.        .... ||.. .. .|  .
gvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgm
0046845 (Phosphotyrosine protein) phosphatases II 333-394 3.5e-10 35.2 In-house 185-256 (284) alignment 
Range on Protein: 333-394
Range on HMM: 185-256/284.0
VYFLPVARYIRAALS--VPQGRVLVHCAMGVSRSATLVLAFLMICE--------NMTLVEAIQTVQAHRNIC
  .|   |..| .|.   ..| ..|||  ||.|..|.... |...         .... ||.. .  .|. .
edlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
0050432 (Phosphotyrosine protein) phosphatases II 333-394 2.6e-09 32.3 In-house 217-281 (308) alignment 
Range on Protein: 333-394
Range on HMM: 217-281/308.0
VYFLPVARYIRAALsvPQGRVLVHCAMGVSRSATLVLAFLM-----ICENMTLVEAIQTVQAHRNIC
  .|   ...|  |  |.| ..|||  ||.|..|.... |.        .... ||....  .|. .
eilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
subfamily_MSG5_pd Subfamily MSG5 337-410 2.8e-11 36.8 In-house 87-160 (165) alignment 
Range on Protein: 337-410
Range on HMM: 87-160/165.0
PVARYIRAALSVpQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAH-RNICPNSGFLRQLQVLDNRL
 ..| | || |  . ..||||  |.||||.|..|..|   |..| .| . ...   .| |. |.. ||   .  |
rltriihaatsk.rkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
Y_phosphatase Protein-tyrosine phosphatase 339-392 5.3e-06 21.4 Pfam-A 159-214 (235) alignment 
Range on Protein: 339-392
Range on HMM: 159-214/235.0
ARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMT--LVEAIQTVQAHRN
 | ..   .  .| |.|||  ||.|..|.|.. .....  .   |.  |.|.  |.
irkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRk
Y_phosphatase Protein-tyrosine phosphatase 339-392 5.3e-06 21.4 In-house 159-214 (235) alignment 
Range on Protein: 339-392
Range on HMM: 159-214/235.0
ARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMT--LVEAIQTVQAHRN
 | ..   .  .| |.|||  ||.|..|.|.. .....  .   |.  |.|.  |.
irkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRk
PTPc_DSPc_SM00012 340-388 1.4e-06 23.8 In-house 24-80 (105) alignment 
Range on Protein: 340-388
Range on HMM: 24-80/105.0
RYIRAALSVPQ-----GRVLVHCAMGVSRSATLVLAFLMICENMTL---VEAIQTVQ
...||  .. .     . |.|||  ||.|..|.|.. .... ...    |.  |.|.
ellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivk
subfamily_PTPDC1_pd Subfamily PTPDC1 345-392 1.8e-06 22.5 In-house 109-156 (182) alignment 
Range on Protein: 345-392
Range on HMM: 109-156/182.0
ALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHRN
| .. .|.| |||  |  |   |. ..|.  ...|  .||..|...| 
afalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp