Gene DUSP26 in Homo sapiens

Synonym: DUSP24, LDP-4, MKP8, NATA1, SKRP3, DUSP26

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP026_AA protein Get Run
HsapP026_AA_59-208 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 44-206 4.8e-48 158.4 In-house 5-171 (178) alignment
Range on Protein: 44-206
Range on HMM: 5-171/178.0
NVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRG----TPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHR
... |. | ..  . ...|.|..||||||.. .|.... |..|||||..| ..   .|     |...|. ||.|| .  .|....|.. ||. . .||..
trvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

ALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLR
||...||..||||  ||.||.|||.||||....|.| |||. |. .| |.||.|.||||. ...||.
aldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrll

0045098 (Phosphotyrosine protein) phosphatases II 52-207 1.4e-33 111.9 In-house 12-273 (278) alignment
Range on Protein: 52-207
Range on HMM: 12-273/278.0
LYTGKTACNHADEVWPGLYLGDQD-----------------------------------------MANNRRELRRLGITHVLNASHSRWR----------
 .  . .... .|..|.||||..|                                         .|.. | |. ||||..... .   .          
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

-------------------------------------GTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQ-------------PGGKILV
                                      . | ..   . ||... |..| .... .|. . .||..||..             .||..||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCAVGVSRSATLVLAYLMLYH---HLTLVEAIKKVKDHRG--IIPNRGFLRQLLALDRRLRQ
||  ||.|..|||.|||||..   ...| ||.|... .|.  ...| ...|.|  . ..|..
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_DSP3_pd Subfamily DSP3 57-207 2.2e-69 226.2 In-house 6-159 (162) alignment
Range on Protein: 57-207
Range on HMM: 6-159/162.0
TACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGT---PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCA
. ....|||.|.||.||...|.....|..|||||||||...|.. .   .| |..|.|.|||.|..|.|.||.| .|.|||.||..||||. ||.||||.
llskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcv

VGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQ
|||||||||||||||.....||||||..|...| |.||.|||.|| .||..|..
vGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkr

0038934 (Phosphotyrosine protein) phosphatases II 58-201 9.5e-23 76.3 In-house 27-172 (194) alignment
Range on Protein: 58-201
Range on HMM: 27-172/194.0
ACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHD---SPAFDMSIHFQTAADFIHRAlsQPGGKILVHCAV
.... |.....||  . ..  .  .|.  ....|.. ...     || .|..||.||     |   .| ...  .|  ..|.....  .|||...|||  
lsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCka

GVSRSATLVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLAL
|..|..||| |||. ...... |||. ... | |.|||...|..||  
GlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr

PTEN_1 59-208 2.3e-33 110.7 In-house 41-194 (196) alignment
Range on Protein: 59-208
Range on HMM: 41-194/196.0
CNhadEVWPGLYLGDQDMA-NNRRELRRLGITHVLNASHSRWR----GTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQP-GGKILVHC
.    |...|||.| .. . .....|   |||.|.| |. ..     ...| ..  |..|| ..  | .| ..| .|  ...||. .||.| |...||||
lq...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

AVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRRLRQG
. |..||.|.| |||| .. ||  ||.. |...|  . || .....||   ..|...
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae

0046846 (Phosphotyrosine protein) phosphatases II 60-205 6.7e-32 106.0 In-house 10-172 (176) alignment
Range on Protein: 60-205
Range on HMM: 10-172/176.0
NHADEVWPGLYLGDQD----------MANNRRELRRLGITHVLNASHSR-------WRGTPEaYEGLGIRYLGVEAHDSPAFDMsIHFQTAADFIHRALS
.. |.....|.||.            .|.. ..|..||||.|.|    .       ..  || .|.|||.|| .   |  . |.  ..... .||..||.
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealk

QPgGKILVHCAVGVSRSATLVLAYLMLY-HHLTLVEAIKKVKDHR--GIIPNRGFLRQLLALDRRL
.  |..||||  |..|..|||.|||. . ..|.. ||...|...|  |........|.|    ..|
eg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll

subfamily_Slingshot_pd Subfamily Slingshot 60-200 8.4e-26 84.4 In-house 17-152 (169) alignment
Range on Protein: 60-200
Range on HMM: 17-152/169.0
NHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrgTPEAYEGlGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRS
..| ...  .||| .  | |  ||.. |....|| ..       . ...  ..|| .  .|... |.  ..... .||..| .. | |.|||| .|||||
dsaskifdhvylGsewnasnleelkengveyilnvtke....idnffpe.kfeylnirvydeeetdllkywnetykfiekakkk.gskvlvhckmGvsrs

ATLVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
|. |.|| |  ..|.| ||.. ||..| .| ||.|||.|| .
astviayamkeyglsleealeyvkerrsvikPnkgflkqlee

subfamily_DSP14_pd Subfamily DSP14 61-207 4.4e-36 118.2 In-house 6-146 (157) alignment
Range on Protein: 61-207
Range on HMM: 6-146/157.0
HADEVWPGLYLGdQDMANNRRELRRLGITHVLNASHsrwrGTPEaYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRaLSQPGGKILVHCAVGVSRSA
.  .. | |.|.    |.....|.. .||...|..      .|.  .  .|... | ..|.|. ... ||...|| |.  ... |||.||||. ||||||
alsqitpsLfls.gvaalskellkkkkitliinvtv....elpn.tklkdiervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCvaGvSRSA

TLVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLRQ
.|.||||| |..|.| || | ||..| || || || .|| .....|..
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg

0041856 (Phosphotyrosine protein) phosphatases II 61-206 5e-36 119.4 In-house 18-173 (182) alignment
Range on Protein: 61-206
Range on HMM: 18-173/182.0
HADEVWPGLYLGDQDM--------------ANNRRELRRLGITHVLNAShsRWRGTPEAYEGLGIRYLGVEAHDSPAFDmsihFQTAADFIHRALSqPGG
. |.....||||..                |.. | |..||||...|..    .  || .| |||.|| .   | ...|    .... |||...|. .||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.egg

KILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRG---IIPNRGFLRQLLALDRRLR
..||||  ||.|..|||.||||......| ||.| |. .|    |.|| .|..||..|...|.
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll

0043147 (Phosphotyrosine protein) phosphatases II 61-205 2.9e-35 116.9 In-house 18-160 (172) alignment
Range on Protein: 61-205
Range on HMM: 18-160/172.0
HADEVWPGLYLGDQDMANNRRELRRLGITHVLNAShsRWRGTPEAYEGLGIRYLGVEAHDSPAFdMSIHFQTAADFIHR-ALSQPGGKILVHCAVGVSRS
. |.......... ..| ..| |..|||||..|.   ..  .|| .| |||.|| .   | ... .. ... . .||.. .. .|||..||||  ||.|.
ipdrfiatqgplrntladfwrmlkelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRt

ATLVLAYLMLyHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRL
.|||.||||| ..|.| ||.. |...|. ...| ...|.|. ....|
gtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

subfamily_DSP10_pd Subfamily DSP10 61-207 5.7e-34 111.3 In-house 13-155 (159) alignment
Range on Protein: 61-207
Range on HMM: 13-155/159.0
HADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrgTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSA
 | .| | |.||..  |..   |.||.||.|||   |    .|  .|. ...|  ....|.   ... .|. | .||. |  . | ..||||  |.||||
pasqvlpfLflGsekdaadldaldrlnitavlnvtts....vPnefeeealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqaGisrsa

TLVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLRQ
|.|.|||| . .|.| .| | ||. | || || .|. ||| ....|..
tvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk

0051082 (Phosphotyrosine protein) phosphatases II 61-201 1.9e-30 100.8 In-house 7-149 (151) alignment
Range on Protein: 61-201
Range on HMM: 7-149/151.0
HADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWR-GTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRS
..  |..|||.... .| . ..|..|||....|      |   || .. |||..| .  .| |.......|.....|.. .|....|..||||  |..|.
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATLVLAYLMLyHHLTLVEAIKKVKDHRG--IIPNRGFLRQLLAL
.|||..|||| ....| ||.. .. .|.  ..|| .|| ||.||
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_STYX_pd Subfamily STYX 61-200 2.1e-20 66.4 In-house 11-152 (166) alignment
Range on Protein: 61-200
Range on HMM: 11-152/166.0
HADEVWPGLYLGDQDMANN--RRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSR
. .|. |||.||    | .     |.. ||||..    .             .||| ..  |..  ..  .. |  .||  .|.. |||.|||   |.||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqk.ggkvlvhgnagisr

SATLVLAYLMLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLA
||.||.||.|  . |   || . |...|  | || || .||  
saalviayimetyglkyreafayvqerrfcinpnegfvsqlke

0048076 (Phosphotyrosine protein) phosphatases II 62-205 6.3e-37 121.8 In-house 4-142 (145) alignment
Range on Protein: 62-205
Range on HMM: 4-142/145.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNAshsrwRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPgGKILVHCAVGVSRSAT
..|..||||||.. .|.....|..||||.|||        ..| .| |||.|| .   | ...|.. ..... .||..||... |..||||  ||.|..|
pseilpglylgslptaldlellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRRL
||.|||||.....| ||...|. .| |..|| |.||.|. ....|
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 62-204 8.5e-37 121.4 In-house 4-143 (144) alignment
Range on Protein: 62-204
Range on HMM: 4-143/144.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSAT
 .|..||||||.. .|..  .|..||||.|.| ...     || .|  ||.|| .  .| ...|.. ..... .||..||. .||..||||  ||.|..|
pseilpglylgslptaldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgt

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRR
||.||||....|.| ||.. |. .| |..||.|.||.|| ....
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

subfamily_DSP19_pd Subfamily DSP19 62-204 7.6e-35 114.5 In-house 12-149 (152) alignment
Range on Protein: 62-204
Range on HMM: 12-149/152.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHsrwrGTPEAYEgLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPgGKILVHCAVGVSRSAT
. || | |||| || |.....|.. .|||.|| .     |.|...    . || .|  | |  |.. ....| |||. |.|.  | .||||  ||||||.
vgeveprlylgsqdvaadkeilkekkitHilnvat....gvpnvfp.kdftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvSRsas

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRR
.|.||||  ..|.| ||...|...|  | || ||..|| ... .
vviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae

subfamily_LRR-DSP_pd Subfamily LRR-DSP 62-205 2.5e-28 92.9 In-house 120-258 (263) alignment
Range on Protein: 62-205
Range on HMM: 120-258/263.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYeglgiRYLGV-EAHDSPAFDMSIHFQTAADFIHRALSQpgGKILVHCAVGVSRSA
 ||. ..|.|| .| |||.  |. ||.||.| |        |. .     .|| . ...| . .|.| ||.    ||.    .  | .||||  |||||.
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklf.....kylsiddiedvdeadisqhfeetnafieeGrkk..GGvlvhcraGvsrss

TLVLAYLMLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRL
|||..||| ...|.. ||.  |. .|  | ||.||. ||.  .. |
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl

0042113 (Phosphotyrosine protein) phosphatases II 62-199 5e-25 83.8 In-house 42-236 (245) alignment
Range on Protein: 62-199
Range on HMM: 42-236/245.0
AD-----EVWPGLYLGDQDMANNRR----ELRRLGITHVLNASHSRWR-------------------------------------------GTPEAYEGL
|      ...|....... ....       |..||||.... .    .                                           |..|  |..
asyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevi

GIRYLGVEahDSPAFDMSIHFQTAADFIHRALS-QPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLL
 ..||...  | .. |.. ... . .|...||.  ..|..||||  ||.|..|...||||      .. ..| ||.|.....| |.... ...|.| 
hyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly

subfamily_DSP8_pd Subfamily DSP8 62-206 2.8e-24 79.5 In-house 15-155 (159) alignment
Range on Protein: 62-206
Range on HMM: 15-155/159.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRwrgtPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSAT
  .. . |||| |  . ..  |..|||..|||||.|     |.  |    ..| |  .|.   ...  |... .|| .| |.  |..|||.  | |||||
ptrilknlylGsqkdvlseellsklgisyvlnasnsc....pkleelkeskflrvPvkDkydekllpwfdksvefidkakse.ngrvlvhvlaGisrsat

LVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLR
...||.| . ...| || . ||..|  | ||  || |||  ...|.
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

subfamily_DSP12_pd Subfamily DSP12 63-198 9.4e-34 111.0 In-house 3-136 (155) alignment
Range on Protein: 63-198
Range on HMM: 3-136/155.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWrgtP-EAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALsQPGGKILVHCAVGVSRSAT
... ||||||.  .... . |. |.|||||   . .    | .  .   .... ... |.|  |.  |...| |||. || . .|..||||..|||||.|
srilpglylggleavqeeellkelkithvlsvikeel...pehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvt

LVLAYLMLYHHLTLVEAIKKVKDH-RGIIPNRGFLRQL
.|.|||| ...| | .|.|.||.  . | || |||.||
iviAYlmkkeklslekAlklvkekkpeiepNegFleQL

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 63-204 1e-33 109.9 In-house 8-146 (148) alignment
Range on Protein: 63-204
Range on HMM: 8-146/148.0
DEVWPG-LYLGDQDMANNRRELRRLGITHVLNASHSRwrgtPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSAT
 |.... |.||.. .| .   |. ||.|.. ||...|    . |..  ||.|| |. .| | .|.|  |.....|...| .. |...|||. .|||||. 
seikdafLFlGskksaadlealkalgvtrivnatker....dnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakde.GrrvLvhlqmGvsrssa

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRR
|.|..|. ... .| ||.  ||. | .. || |||.||  |...
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa

0036282 (Phosphotyrosine protein) phosphatases II 63-204 1.3e-32 108.3 In-house 13-168 (174) alignment
Range on Protein: 63-204
Range on HMM: 13-168/174.0
DEVWPGLYLGDQDMAnNRRELRRLGITHVLNASHSRWRG----------TPEAYEGLGIRYLGVEAHDSPAFDMSIhFQTAADFIHRALSQ-PGGKILVH
 ...|.|..|.  .| . ..|..||||.|..  ... .|          ..| .| |||.|| .   |  ..|.|| .... .|...|||. |||..|||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CAVGVSRSATLVLAYLMLYHHL-TLVEAIKKVKDHR----GIIPNRGFLRQLLALDRR
|  ||.|..|||.|||||...| .||.|.. |.  |    |.... ...|.|  ... 
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl

0049260 (Phosphotyrosine protein) phosphatases II 63-203 7.5e-32 105.5 In-house 9-147 (152) alignment
Range on Protein: 63-203
Range on HMM: 9-147/152.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLgiRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATL
 |.......|....|.. | |..||||....     ..| .  ...   .|| .   |... |.|.... . .||.... ..||..||||  ||.|..||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VLAYLMLyHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDR
|.||||| ....| ||.. |. .|  ..|| |.||.|.  ..
vaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek

subfamily_DSP15_pd Subfamily DSP15 63-200 2.7e-30 99.5 In-house 3-134 (151) alignment
Range on Protein: 63-200
Range on HMM: 3-134/151.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEayeglgIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATL
..| ||||||.   ....  |..  |||.|. . .  .  ..      |.|. ..| |.|  ..| .|. . .|||.. .. ....||||..|||||.||
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd......ieYkciaasDtpsaklskffkesvefihkcRlk.eenvlvhClaGvsRsvtl

VLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
| ||||   .|   .|.. .| .| .  || || |||  
vvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlke

subfamily_DSP6_pd Subfamily DSP6 63-206 5.5e-30 98.0 In-house 15-155 (158) alignment
Range on Protein: 63-206
Range on HMM: 15-155/158.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRwrgtPEAYEGLG-IRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSAT
 |. | |||| .. |.|.  |..|.| .|||  . .    |...|  | ..|| . ..|    ... .|  | .||  | |.   |.||||  |.||| |
veilpllylGsakdasnlevlkklkikyvlnvtsnl....pnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.kskvlvhClaGisrsvt

LVLAYLMLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRLR
..||||| ...|.| .| . ||...  | ||  |. |||  .|.||
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr

0036941 (Phosphotyrosine protein) phosphatases II 63-201 2.9e-22 74.7 In-house 20-272 (297) alignment
Range on Protein: 63-201
Range on HMM: 20-272/297.0
DEVWPGLYLGDQDMANNRRELR----------------------------------------------------------RLGITHVLNASHSRWR----
.|..| |.||. . |.. . |                                                            ...|.... .    .    
eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

---------GTPEAYEGLGIRYLGVEA-----------------------------HDSPAFDMSIHFQTAADFIHRALS-----QPGGKILVHCAVGVS
         | .  |... ...|.||                              .. | ...  ....  |||.....      .||..||||  ||.
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSATLVLAYLM--------LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLAL
||.|...|.||         .. ....||.||....| |.... ...|.|  .
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea

subfamily_DSP1_pd Subfamily DSP1 64-205 4.5e-37 121.6 In-house 20-156 (163) alignment
Range on Protein: 64-205
Range on HMM: 20-156/163.0
EVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrgTPEAYEGlGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATLV
.. . |||| .  | |.. |..||||..||.|..    .....|    .|  .. .|||  |.| .|... .||... .. .||.|.||..|.|||.||.
kildfLylGsetvasnleiLkslgitailnvske....ldnvfed.lfeYkklkleDspkadislvfeeviefidevkkk.nGkvlihCqaGisRsstlc

LAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRL
|||||  ....| || . ||..| || || || .|||  ...|
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl

PTPc_motif_SM00404 64-202 2.1e-35 116.7 In-house 4-138 (140) alignment
Range on Protein: 64-202
Range on HMM: 4-138/140.0
EVWPGLYLGDQDMANNRRELRRLGITHVLNASH-SRWRgtpeaYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATL
.. |.|||| .. |.|.. |  ||||||.|..   ...     .|  |...| .. .|.   ..| ... ..|||..|  . |||.||||..||||||||
rilphlylgskskaqnpallkklgithvinvteevslt.....kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRSatl

VLAYLMLYHHLTLVEAIKKVKDHRGI-IPNRGFLRQLLALD
..|||| |..|.| ||.. ||. | |  || .|.|||. . 
iiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye

0037934 (Phosphotyrosine protein) phosphatases II 64-200 1.8e-26 88.6 In-house 41-236 (243) alignment
Range on Protein: 64-200
Range on HMM: 41-236/243.0
EVWPGLYLGDQ--------DMANNRRELRRLGITHVLNASHSR------------------------------------------WRGTPEAYEGLGIRY
.|.|.|.....        |.|.. | | .||||....  .                                            .  ... ...  . |
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

LGVEAHDSPA--FDMSIHFQTAADFIHRA----LSQPGGKILVHCAVGVSRSATLVLAYLMLYH-HLTLVEAIKKVKDHRG--IIPNRGFLRQLLA
|..  |. |    |.  ... . .||...       .||..||||  ||.|..||..|||||.. ...| ||.|.....|.  ........|.|  
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye

0051429 (Phosphotyrosine protein) phosphatases II 64-201 2.4e-21 72.0 In-house 18-220 (272) alignment
Range on Protein: 64-201
Range on HMM: 18-220/272.0
EVWPG-LYLGDQD---MANNRRELRRLGITHVLNASHSRWRGTPE-AYEGLGIRYLGVEAHDSPAFDMSIHF----------------------------
.|.|| ||....     |.. . |..|||.....  .   ||     ..  ||||| .  .|. |.......                            
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------QTAADFIHRALSqpGGKILVHCAVGVSRSATLVLAYLMLyHHLT--------------LVEAIKKVKDHR-GIIPNRGFL
                    ..  ....  |.  ||..||||. |..|..|.|...|.| . ..              | ||.......| |.... ...
earevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

RQLLAL
..|.  
lflyea

subfamily_STYXL1_pd Subfamily STYXL1 64-203 6.7e-18 58.4 In-house 13-151 (157) alignment
Range on Protein: 64-203
Range on HMM: 13-151/157.0
EVWPG-LYLGDQDMANNRRELRRLGITHVLNASHSRWRgtpeAYEGL--GIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSA
|| || ||||.   | |..  . | .  ..| |.   .     ..|.    . | .. .|..  |.  ... | .||..     |  .||    |.||||
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk....liagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsa

TLVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDR
....|||| ....|| .| |..|. .  . |||.|. ||   ..
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek

0040439 (Phosphotyrosine protein) phosphatases II 65-202 7.3e-26 86.7 In-house 32-242 (249) alignment
Range on Protein: 65-202
Range on HMM: 32-242/249.0
VWPGLYLG------------------------DQDMANNRRELRRLGITHVLNASHSRWRGTPEA-----------------------------------
..|||.|.                        .. .....| |..||||.......   .|                                       
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---YEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALS-----QPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPN
   |.|  ...|..  .| | .. . .|... |||.....      .||..||||  ||.|..|...||||      .....| ||.|.....| |...|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

RGFLRQLLALD
 ...|.|. . 
peqyrflyeal

0045450 (Phosphotyrosine protein) phosphatases II 66-201 4.2e-24 81.3 In-house 94-299 (307) alignment
Range on Protein: 66-201
Range on HMM: 94-299/307.0
WPGLYLGDQDMANNR----------------RELRRLGITHVLNASHSRWRGTP-----------------------EAYEGLGIRYLGVEAHDS-----
.| |.|.|    ...                | |...|.|.... ...  .| .                       . ..  |. .. .| .|.     
vpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtge

------------PAFDMSIHFQTAADFIHRALS-----QPGGKILVHCAVGVSRSATLVLAYLMLYHH--------LTLVEAIKKVKDHR-GIIPNRGFL
            | .. . .|... |||.....     ..||..||||  ||.|..|...|||||...        ..| ||.|.....| |...| ...
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

RQLLAL
|.|  .
rflyea

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 68-206 2.4e-27 89.2 In-house 9-153 (154) alignment
Range on Protein: 68-206
Range on HMM: 9-153/154.0
GLYLGDQDMANNRRELRRLGITHVLNASH---SRWRGT-PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAL-SQPGGKILVHCAVGVSRSATL
 ||.. .| | |. .|.   |...|| .      .     .  .|. | || .| .| . ||.  ... | .||. |. .   .|.|||.  ||||||.|
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLR
...|||   ...| .|.. .|| | || ||.|||.||   ...|.
lisylmdklkislslalellkdsryiikPnqGflkqleifekell

DSPc Dual specificity phosphatase, catalytic domain 69-203 2.3e-32 106.7 Pfam-A 1-132 (133) alignment
Range on Protein: 69-203
Range on HMM: 1-132/133.0
LYLGDQDMANnRRELRRLGITHVLNASHSR-WRgtpEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYL
|||| .  |.  . |  ||||.|.|....  ..    |..   |.||..  .|.   ..| ... | .||..|  | |.|.||||. |.||||||..|||
lylgskstas.lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYl

MLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDR
| ...|.| ||.. ||. |. | || |||||||...|
mktknlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 69-203 2.3e-32 106.7 In-house 1-132 (133) alignment
Range on Protein: 69-203
Range on HMM: 1-132/133.0
LYLGDQDMANnRRELRRLGITHVLNASHSR-WRgtpEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYL
|||| .  |.  . |  ||||.|.|....  ..    |..   |.||..  .|.   ..| ... | .||..|  | |.|.||||. |.||||||..|||
lylgskstas.lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYl

MLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDR
| ...|.| ||.. ||. |. | || |||||||...|
mktknlslneAyefvkerrskispnagflrqLleyer

0049772 (Phosphotyrosine protein) phosphatases II 69-205 5.5e-31 103.8 In-house 155-273 (314) alignment
Range on Protein: 69-205
Range on HMM: 155-273/314.0
LylgDQDMANNRRELRrlgithvlnashsrwR--GTPEAYEGLGIRYLGVEAHDsPAFDMSIHFQTAADFIHRAlsQPGGKILVHCAVGVSRSAT-LVLA
    ..  | .  .|.               .    || .|.|||.|| .   | . .. . .|. . .||..|  ..||..||||. |..|..| .|.|
g...neptaadlellk...............eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaa

YLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRL
|||......| ||.. |.  | | ||.||..||. .  .|
ylmkllgvsleealedvrlkRpinpnpgfieqleqyefil

subfamily_MKPLT_pd Subfamily MKPLT 69-200 3.4e-28 92.2 In-house 29-155 (164) alignment
Range on Protein: 69-200
Range on HMM: 29-155/164.0
LYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAyeglgIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSATLVLAYLM
||||. . |.|.. |. | |||..| |  .    |..     . || |. .| .   .| ... ||.|.  |.   ||..||||  |.|||..  .|.|.
lylGnakhatnekvlkdlkithivnvsqekkdafpks.....veYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvtvafLi

LYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
...  || || . .|. | |. ||||||.||  
kskgwtlkeayeylkerrsivapnrGflkqlak

subfamily_MKPLV_pd Subfamily MKPLV 69-200 3.4e-28 92.2 In-house 29-155 (164) alignment
Range on Protein: 69-200
Range on HMM: 29-155/164.0
LYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAyeglgIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSATLVLAYLM
||||. . |.|.. |. | |||..| |  .    |..     . || |. .| .   .| ... ||.|.  |.   ||..||||  |.|||..  .|.|.
lylGnakhatnekvlkdlkithivnvsqekkdafpks.....veYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvtvafLi

LYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
...  || || . .|. | |. ||||||.||  
kskgwtlkeayeylkerrsivapnrGflkqlak

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 69-207 2.7e-25 82.2 In-house 6-143 (145) alignment
Range on Protein: 69-207
Range on HMM: 6-143/145.0
LYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYeGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATLVLAYLM
|| |    ||.   |. |||. ..| . .    . |.. .  |  | . |.|  ..|.| ||.  .||| .   . |  ..|||  ||||| |. .|.||
lyvgsalhandvptlqelgisrivnmaagslvasqelk.sesieillitaedlesydlsqhfdevtdfidkgkee.gagvfvhcmagvsrsvtvsvaflm

LYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRLRQ
 |  .|| || ..|. .|   .||  ||..|| |...|..
kycnmtlseaarqvrsnrllaypnvtflknllnlekqlke

0040438 (Phosphotyrosine protein) phosphatases II 80-201 5.1e-20 67.4 In-house 103-271 (317) alignment
Range on Protein: 80-201
Range on HMM: 103-271/317.0
RRELRRLGITHVLNASHSRWRGT----------------------PEAYEGLGIRYLGVEAHDS----------------PAFDMSIHFQTAADFIHRAL
 | . ..|.|....  ..  .|                        . .|  || .. .|  |.                | ..   ....  ||.... 
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

SQ---PGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLAL
..   |||..||||  ||.|..|...||||      ...... ||.|... .|. .... ...|.|  .
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

0043336 (Phosphotyrosine protein) phosphatases II 80-199 1.2e-19 66.3 In-house 105-270 (278) alignment
Range on Protein: 80-199
Range on HMM: 105-270/278.0
RRELRRLGITHVLNASHSRWR------------------------------------------GTPEAYEGLGIRYLGVEAHDSPAfDMSIHFQTAADFI
.| .. ||.|....      .                                          |..| ...... |||.  |. |  ..|....   ...
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavr

HRALsQPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLL
..    ..|..||||  ||.|..|....||.      .....| ||.|... .| |....  ..|.| 
eale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly

0039614 (Phosphotyrosine protein) phosphatases II 80-203 1.6e-19 66.0 In-house 118-286 (297) alignment
Range on Protein: 80-203
Range on HMM: 118-286/297.0
RRELRRLGITHVLNASHSR---------WRGTPEAYEGLGIRYLGVEA----------------------------HDSPAFDMSIHFQTAADFIHRALS
 | ....|.|....              |  . . |... ...|.||                              |  . . . ... . .....||.
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

Q--PGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDR
.  .||..||||  ||.|..|...||||      ...... ||.|... .| |.... ...|.|  . .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

subfamily_DSP23_pd Subfamily DSP23 81-186 3.1e-07 25.2 In-house 25-125 (148) alignment
Range on Protein: 81-186
Range on HMM: 25-125/148.0
RELRRLGITHVLNAShSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADfihRAlSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIK
| |  ||. ...  .  . |   ||  .| .  |... .  || .   .|    .    |  . .  . |||. |  |. |..  ||.  ..|.  ||| 
rylldlgvrylvslt.eegrphveatpnltlvrlriddyhppaleqvvefvrvve...ea.eekneavsvhcllgrgrtgtmlacylvkerklaaaeaia

KVKDHR
.|.  |
evrrlr

0051299 (Phosphotyrosine protein) phosphatases II 99-187 1.9e-13 46.0 In-house 175-266 (288) alignment
Range on Protein: 99-187
Range on HMM: 175-266/288.0
WRGTPEAYEGLGIRYLGVEAHDSPAfdMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHRG
..|. | ..   . |..   |. |      .. .   ....||...|| ..|||  ||.|..|.....|.       ..... ||.|... .| 
ldgdgesrtvthfhytnwpdhgvpd..spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp

subfamily_PTPMT1_pd Subfamily PTPMT1 100-192 4.6e-15 50.5 In-house 63-154 (171) alignment
Range on Protein: 100-192
Range on HMM: 63-154/171.0
RGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNR
  . | .. ||. .| ..  |        . . . .||..  |. | .. |||  | .|||||| .|||. ..|.. ||.| .|. | ||  .
ansteewkklgveqlqlatvDfteapdleklekgvefiekvask.gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirla

0047943 (Phosphotyrosine protein) phosphatases II 101-195 4.1e-14 48.2 In-house 161-261 (273) alignment
Range on Protein: 101-195
Range on HMM: 161-261/273.0
GTPEAYEGLGIRYLGVEAHDSP-AFDMSIHFQTAADFIHRALSQPgGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRG
||.| ..   . |.|   |. |  ... ..|  ... ...|| .. |...|||  ||.|..|.....|.      .. ... ||.|.....| |....  
gtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe

FL
..
qy

0046845 (Phosphotyrosine protein) phosphatases II 102-187 3.7e-13 44.9 In-house 161-254 (284) alignment
Range on Protein: 102-187
Range on HMM: 161-254/284.0
TPEAYEGLGIRYLGVEAHDSPA-FDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYLMLYH--------HLTLVEAIKKVKDHRG
| | ..   . |..   |. |. ..  ..|  ... .... . .||.|.|||  ||.|..|.....|.|..        .... ||.|.....| 
tgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp

subfamily_DSP11_pd Subfamily DSP11 102-192 9e-07 22.9 In-house 71-163 (178) alignment
Range on Protein: 102-192
Range on HMM: 71-163/178.0
TPEAYEGLGIRYLGV--EAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNR
 .....  |..|| .    |. |  ..  .|. | .       . .  | |||. || |.  |.  ||.  . .   .||.. .. ||   .|
kkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler

subfamily_RNGTT_pd Subfamily RNGTT 109-186 1.8e-06 21.8 In-house 76-154 (189) alignment
Range on Protein: 109-186
Range on HMM: 76-154/189.0
LGIRYLGV--EAH-DSPAFDMSIHFQTAADFIHRalSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHR
 ||.|  .  ... ..|  .   .|..  .  ..   .|   | |||  |  |.  |. .||.  ..  . .|..  .  |
egikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaR

subfamily_Laforin_pd Subfamily Laforin 110-177 3.5e-06 20.0 In-house 76-142 (183) alignment
Range on Protein: 110-177
Range on HMM: 76-142/183.0
GIRYLGVEAHDSPAfDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVE
|. |. .  .|  . .  ..    | ..  || . | .. |||  || ||...|  .|.   . .|  
glayiwlptedlst.esrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslak

0050432 (Phosphotyrosine protein) phosphatases II 111-187 8.3e-12 40.5 In-house 202-279 (308) alignment
Range on Protein: 111-187
Range on HMM: 202-279/308.0
IRYLGVEAHDSPA-FDMSIHFQTAADFIHralsqPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHRG
. |.. . |. |  ... ..|  ...  .     |||.|.|||  ||.|..|.....|.       ..... ||.||.. .| 
fhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp

Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 114-174 7.8e-06 16.2 Pfam-A 344-405 (451) alignment
Range on Protein: 114-174
Range on HMM: 344-405/451.0
LGVEAHDSPAFDMSIHFQTAADFIHRALSQ-PGGKILVHCAVGVSRSATLVLAYLMLYHHLT
|..|.    . ... .......||.. ||. .  ||||.|  |   |...||| | ||....
lklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdee

0048567 (Phosphotyrosine protein) phosphatases II 123-186 3.8e-10 34.3 In-house 52-118 (157) alignment
Range on Protein: 123-186
Range on HMM: 52-118/157.0
AFDMSIHFQTAADFIHRALSQPGGKILVHCAVGV---SRSATLVLAYLMLYHHLTLVEAIKKVKDHR
  .. ..| . .. . . |.  |..| |||  |    .|.|||. .||.|....|  |||. ..  |
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

subfamily_CDC14_pd Subfamily CDC14 125-181 1.2e-06 22.6 In-house 243-299 (328) alignment
Range on Protein: 125-181
Range on HMM: 243-299/328.0
DMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKK
| |.  ..      ... .  |.| |||  |. |  ||. .|||  ...|  |||  
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiaw

NMT Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain 125-165 8.2e-06 11.9 Pfam-A 53-93 (162) alignment
Range on Protein: 125-165
Range on HMM: 53-93/162.0
DMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLA
|    |. ...|.. || .|| |   |. | |...  ||  
damfrfdyskeflkwalkapGfkkdwhvGvrvkktkklvaf

PTPc_DSPc_SM00012 129-172 1.2e-07 27.2 In-house 21-66 (105) alignment
Range on Protein: 129-172
Range on HMM: 21-66/105.0
HFQTAADFIHRALSQP--GGKILVHCAVGVSRSATLVLAYLMLYHH
.. .. . ...  ..   .. ..|||  ||.|..|.|.....| ..
silellravkknknksesskpvvVhCsaGvgRtgtfvaldillqql

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 129-161 4.5e-06 20.6 In-house 210-242 (301) alignment
Range on Protein: 129-161
Range on HMM: 210-242/301.0
HFQTAADFIHRALSQPGGKILVHCAVGVSRSAT
  |   | |||  .  ||...|||  .|||| .
vLqviddvihrqqkigggpvvVHCSdtVsrsGv

subfamily_MSG5_pd Subfamily MSG5 131-202 1.2e-16 54.3 In-house 86-157 (165) alignment
Range on Protein: 131-202
Range on HMM: 86-157/165.0
QTAADFIHRALSQpGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDH-RGIIPNRGFLRQLLALD
 . .  || | |. . ||||||  |.||||.|..||.| |. |.| .| .|.|     | |. |.. ||.  .
srltriihaatsk.rkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe

Y_phosphatase Protein-tyrosine phosphatase 132-186 6.2e-06 21.2 Pfam-A 154-216 (235) alignment
Range on Protein: 132-186
Range on HMM: 154-216/235.0
TAADFIHRALSQP---GGKILVHCAVGVSRSATLVLAYLMLYHHLT-----LVEAIKKVKDHR
   |.|..  ..     |...|||  ||.|..|.|.. ..| .  .     .....|... .|
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR

Y_phosphatase Protein-tyrosine phosphatase 132-186 6.2e-06 21.2 In-house 154-216 (235) alignment
Range on Protein: 132-186
Range on HMM: 154-216/235.0
TAADFIHRALSQP---GGKILVHCAVGVSRSATLVLAYLMLYHHLT-----LVEAIKKVKDHR
   |.|..  ..     |...|||  ||.|..|.|.. ..| .  .     .....|... .|
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR

subfamily_PTPDC1_pd Subfamily PTPDC1 139-187 2.7e-07 25.2 In-house 110-156 (182) alignment
Range on Protein: 139-187
Range on HMM: 110-156/182.0
RALSQpgGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRG
 ||..  ||. |||  |  |   |. .||.  ..||  .|||.|...| 
falqe..gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp