Gene DUSP27 in Homo sapiens

Synonym: DUSP27

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP027_AA protein Get Run
HsapP027_AA_131-282 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP19_pd Subfamily DSP19 123-278 7.1e-32 104.9 In-house 3-150 (152) alignment 
Range on Protein: 123-278
Range on HMM: 3-150/152.0
VQDRQEAPwnEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytgPEFYTgLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYrGKVL
|.| .|    || || |..... ..|| .|  ||. .|||||| | |.     |....  ...|| .|. | || |.......| .|..||. .  | ||
veDlkedl..evgeveprlylgsqdvaadkeilkekkitHilnvatgv.....pnvfp.kdftylsieilDlpetdllsylkealdFieearskd.gavl

VSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEKL
|  . |.|||| .|.||||  ... . ||| .||..| .| |||||.|||.|....|
vHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0049772 (Phosphotyrosine protein) phosphatases II 123-278 8.3e-26 86.9 In-house 125-273 (314) alignment 
Range on Protein: 123-278
Range on HMM: 125-273/314.0
VQDRQEAPWNE------------VDEVWPNVfiaE-KsVAVNKGRLKrlgithilnaahgtGVYTGPEFYTGLEIQYLGVEVDDfPEVDISQHFRKASEF
| .|.|. ..|              ....|        .| .   ||              .... ||....| |.|| . |.| ........|... ||
vmsrdevladelsrLdaAlgKtpllildgng...nep.taadlellk..............eelydpelferlgikylripvpD.gsaplledfdeflef

LDEAllTYRGKVLVSSEMGISRSAV-LVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKL
..||     |.|||   .|..|... .|.||||. ... . |||  ||.|| |.||.||..||... ..|
ieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefil
0044763 (Phosphotyrosine protein) phosphatases II 125-282 1e-34 115.1 In-house 14-174 (178) alignment 
Range on Protein: 125-282
Range on HMM: 14-174/178.0
DRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYT---GPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKV
. . .... ..|..|.....    | ..  ||.||||||.| .. .  .     |..... .|||| . ..|... |...||... ||..||| .  |.|
glersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpv

LVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEER
||   .|..||..||.||||. ... . ||.  ||..| |.||.|.|.||.|. ..|..|.
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkes
subfamily_DSP3_pd Subfamily DSP3 126-282 5.7e-70 228.2 In-house 3-161 (162) alignment 
Range on Protein: 126-282
Range on HMM: 3-161/162.0
RQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHG--TGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLV
.......|||||.|........|| .| .||.|||||.||||.|  . |.||.|||..|||.|||.||||.||.|.|..|..|..|.|||| . .|||||
lerllskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlv

SSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEER
....|.||||.||.|||||...|.. ||..||||||.|.|||||||||.||.|.|....
hcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkrkk
0036282 (Phosphotyrosine protein) phosphatases II 129-275 6e-20 67.1 In-house 7-166 (174) alignment 
Range on Protein: 129-275
Range on HMM: 7-166/174.0
APWNEVDEVWPNVFIAEKSVAvNKGRLKRLGITHILNAAHGTGVY---------TGPEFYTGLEIQYLGVEVDDFPEVDISQhFRKASEFLDEALLT-YR
|..  . ...|....     | .   ||.||||....  .              . .|... | |||| . ..|. . |.|. .... .|..|||.    
aspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpg

GKVLVSSEMGISRSAVLVVAYLMIFHNM-AILEALMTVRKKR----AIYPNEGFLKQLRELN
|.|||   .|..|...||.||||. . .    .|| .||..|     ..........|....
gpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
PTEN_1 129-281 8.6e-20 66.4 In-house 35-194 (196) alignment 
Range on Protein: 129-281
Range on HMM: 35-194/196.0
APWNE-VDEVWPNVFIAEKSVAV-NKGRLKRLGITHILNAAHGT---GVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTY-RGKVL
||.    .|.......   . .. .. .||  |||...| ...    |.   .|..    ..|| ....|..  ..|..|. . .| . .|.   ...||
apsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

VSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEKLMEE
|    |..||...| ||||  ...   |||  ||.|| .. || .....|.|  ..| .|
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0045098 (Phosphotyrosine protein) phosphatases II 131-279 1.5e-21 72.5 In-house 19-272 (278) alignment 
Range on Protein: 131-279
Range on HMM: 19-272/278.0
WNEVDEVWPNVFIAEKS-----------------------------------------VAVNKGRLKRLGITHILNAAHGTGVY----------------
.. ..|..|....  ..                                         || .   |. ||||.|..... .                   
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

------------------------------TGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLT-------------YRGKVLVSSEMGIS
                              .. | ..   ..||...  . |. .|...| .. ||..||| .               |.|||   .|..
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSAVLVVAYLMIFH---NMAILEALMTVRKKRA--IYPNEGFLKQLRELNEKLM
|...||.||||. .   .. .|||. ..|..|   . .|......| |.  .| 
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0036941 (Phosphotyrosine protein) phosphatases II 131-277 5.8e-14 47.5 In-house 16-275 (297) alignment 
Range on Protein: 131-277
Range on HMM: 16-275/297.0
WNEVDEVWPNVFIAEKSVAVNKGRLK----------------------------------------------------------RLGITHILNAAHGTGV
. | .|..|. .. ..||| ... |.                                                           ...|.|..    .  
lkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

Y------------TGPEFYTGLEIQYLGVEV-----------------------------DDFPEVDISQHFRKASEFLDEALL-----TYRGKVLVSSE
              ..  | .. ...|.|||                              . |. .. ....   .|.....      .  |.||| . 
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

MGISRSAVLVVAYLM--------IFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEK
.|..||.....|.||        . ... ||||. ..|..|  . ........|.|.  .
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
subfamily_DSP14_pd Subfamily DSP14 132-281 1.3e-27 90.7 In-house 5-147 (157) alignment 
Range on Protein: 132-281
Range on HMM: 5-147/157.0
NEVDEVWPNVFIAeKSVAVNKGRLKRLGITHILNAAHgtgvyTGPEfYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISR
... .. |. |..  ..|..|  ||. .||.|.|..        |.  .  .|... | |.| ||.....|| .... ..|.  .  ||.||   .|.||
aalsqitpsLfls.gvaalskellkkkkitliinvtv.....elpn.tklkdiervkvpveDnpeaklakhfdevadkieev.kkkggktlvhCvaGvSR

SAVLVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNEKLMEE
|| |..|||| ...... ||  .|...|  | || || |||... .|| ..
SAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
subfamily_DSP10_pd Subfamily DSP10 132-281 3.1e-26 86.1 In-house 12-156 (159) alignment 
Range on Protein: 132-281
Range on HMM: 12-156/159.0
NEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHgtgvyTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTyRGKVLVSSEMGISR
 .. .| | .|. ..  | ..  |.||.||..|| .      . | .... ...|  ..| |  . ...|.| .| ||..||  .   .|||  . ||||
apasqvlpfLflGsekdaadldaldrlnitavlnvtt.....svPnefeeealkYkripvsDtskqnlkqyfeealefieearkk.gsrvLvhCqaGisr

SAVLVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNEKLMEE
|| .|.||||   |... .|   |..||. | || .|. || |....| ..
satvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_STYX_pd Subfamily STYX 132-276 3.1e-21 69.2 In-house 10-155 (166) alignment 
Range on Protein: 132-276
Range on HMM: 10-155/166.0
NEVDEVWPNVFIAEKSVAVNK--GRLKRLGITHILNAAHGT-GVYTGPEFYTglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMG
 |..|. | .|.   | |..     ||. |||||.         .  |.|    ...|| ..| | .  .| ... .  ||.|..|    |||||  . |
remqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpd..rfrylvldvadntveniirylptvkefiddsl.qkggkvlvhgnag

ISRSAVLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNE
||||| ||.||.|  . ..  || . |...|  | ||||| .||.| . 
isrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0051082 (Phosphotyrosine protein) phosphatases II 132-274 3.2e-19 64.4 In-house 6-149 (151) alignment 
Range on Protein: 132-274
Range on HMM: 6-149/151.0
NEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISR
     |......     | .   ||.|||..|.|    .  .. ||... |.|..| . ..|.|. .....|  . |||...| .  |.|||   .|..|
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgR

SAVLVVAYLMIfHNMAILEALMTVRKKR--AIYPNEGFLKQLREL
...||..|||. ... . |||  .|.||  ...||..||.||..|
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP1_pd Subfamily DSP1 133-282 1.5e-29 97.2 In-house 17-160 (163) alignment 
Range on Protein: 133-282
Range on HMM: 17-160/163.0
EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytgPEFYTGlEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRS
 | .. . ...  ..|| |.  ||.||||.|||... .     ....     .|  ....| |. |||..|... ||.||.  . .||||.  ..|||||
PvekildfLylGsetvasnleiLkslgitailnvskel.....dnvfed.lfeYkklkleDspkadislvfeeviefidevk.kknGkvlihCqaGisRs

AVLVVAYLMIFHNMAILEALMTVRKKRAI-YPNEGFLKQLRELNEKLMEER
. |..||||  ... . ||   |...|.|  || || .|| . ..||. | 
stlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel
subfamily_DSP12_pd Subfamily DSP12 133-280 4.4e-27 89.4 In-house 1-145 (155) alignment 
Range on Protein: 133-280
Range on HMM: 1-145/155.0
EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGvytgPEFYTGLE-IQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISR
||... |...... . .... .|| |.|||.|  .. .     ||. .    .... ....| ||.|| .|. .| .|..|||   .|.|||  ..|.||
evsrilpglylggleavqeeellkelkithvlsvikeel....pehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSR

SAVLVVAYLMIFHNMAILEALMTVR-KKRAIYPNEGFLKQLRELNEKLME
|. .|.||||  ... . .|| .|. ||. |.||||||.||.  ..  ..
SvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
0041856 (Phosphotyrosine protein) phosphatases II 133-279 7.9e-25 82.9 In-house 18-173 (182) alignment 
Range on Protein: 133-279
Range on HMM: 18-173/182.0
EVDEVWPNVFIAEKSV--------------AVNKGRLKRLGITHILNAAhgtGVYTGPEFYTGLEIQYLGVEVDDFPEVDisqhFRKASEFLDEALLtYR
  |....|...                   | .   ||.||||.|.|..   ...  ||... | |||| . ..|..  |    .... .|..|.|    
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.eg

GKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRA---IYPNEGFLKQLRELNEKLM
|.|||   .|..|...||.||||. ... . ||. .||..|    |.|| .|. || .| ..| 
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0046846 (Phosphotyrosine protein) phosphatases II 133-278 1.9e-22 75.3 In-house 11-172 (176) alignment 
Range on Protein: 133-278
Range on HMM: 11-172/176.0
EVDEVWPNVFIAEKS----------VAVNKGRLKRLGITHILNAAHGT-----GVYTGPEFYTGLEIQYLGVEVDDFPEVDIsQHFRKASEFLDEALLTY
 .|....|...  .           .| .  .||.||||...|    .     .... .. ...|.|||| . ..|.   |. ... .. ||..|||   
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

rGKVLVSSEMGISRSAVLVVAYLMIF-HNMAILEALMTVRKKR--AIYPNEGFLKQLRELNEKL
 |.|||   .||.|...||.|||..  ... ..||| .||..|   . ........|.|   .|
.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0042113 (Phosphotyrosine protein) phosphatases II 133-273 4e-15 51.4 In-house 46-237 (245) alignment 
Range on Protein: 133-273
Range on HMM: 46-237/245.0
EVDEVWPNVFIAEKSVAVNKG----RLKRLGITHILNAAHGTGVYTG----------------------------------------PEFYTGLEIQYLG
 .....|.....    . . .     |..||||.|..    .                                             .....   |.|. 
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

VEVDDFPEVDISQHFRKASEFLDEALL-TYRGKVLVSSEMGISRSAVLVVAYLM-----IFHNMAILEALMTVRKKR-AIYPNEGFLKQLRE
. ..|... |..... .. ||...||  .  |.||| . .|..|......||||       ... . ||.  .|..|  . ........|.|
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
PTPc_motif_SM00404 134-276 2.1e-27 90.7 In-house 2-139 (140) alignment 
Range on Protein: 134-276
Range on HMM: 2-139/140.0
VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYtgpefYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISRSA
. .. |......|| |.|.  || |||||..|..    .      .   ..|.| ...||  . ..|....|. .|...|  . .|||||   .|.||||
psrilphlylgskskaqnpallkklgithvinvteevslt.....kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRSa

VLVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNE
 |..||||  ... . ||.  |...|  | ||..|..|| |...
tliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048179 (Phosphotyrosine protein) phosphatases II 134-277 8.3e-26 85.8 In-house 4-143 (144) alignment 
Range on Protein: 134-277
Range on HMM: 4-143/144.0
VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGtgvyTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYrGKVLVSSEMGISRSA
..|..|....    .|..  .||.||||...| ...      |||..   |||| . ..|..  |........ ||..|||    |.|||   .|..|..
pseilpglylgslptaldlellkklgittvinltee....yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtg

VLVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNEK
.||.||||. ... . |||  ||..|  ..||.|.|..|.|....
tlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP15_pd Subfamily DSP15 134-282 1.2e-23 77.9 In-house 2-144 (151) alignment 
Range on Protein: 134-282
Range on HMM: 2-144/151.0
VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHgtgvyTGPEFYTglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTyRGKVLVSSEMGISRSA
...| |......  .. .. .||.  |||||.           ..    .|.|. ....| |....|..|... ||. .. |   ..|||   .|.|||.
iskvlpglylgnfrdskdeelLkeknithilsvhd.....nakkllk..dieYkciaasDtpsaklskffkesvefihkcRlk.eenvlvhClaGvsRsv

VLVVAYLMIFHNMAILEALMTVRKKRAI-YPNEGFLKQLRELNEKLMEE-R
 |||||||   ..   .|| .....|..  || || .||.| ... ..| |
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyr
0043147 (Phosphotyrosine protein) phosphatases II 134-278 1.9e-23 78.5 In-house 19-160 (172) alignment 
Range on Protein: 134-278
Range on HMM: 19-160/172.0
VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAhgtGVYTGPEFYTGLEIQYLGVEVDDFPEVdISQHFRKASEFLDE-ALLTYRGKVLVSSEMGISRS
 |..... .     .| .   ||.||||||.|.    . .. ||... | |||| . ..|..   ........ ||.|| ..|   |.|||   .|..|.
pdrfiatqgplrntladfwrmlkelgithivnlt...ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRt

AVLVVAYLMIfHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNEKL
..||.||||. ... ..||. .||.||  . .|......|......|
gtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP8_pd Subfamily DSP8 134-280 9e-19 61.6 In-house 15-156 (159) alignment 
Range on Protein: 134-280
Range on HMM: 15-156/159.0
VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHgtgvyTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSA
. .. .|...  . .....  |..|||...||| .     . |.  .  | ..| | | |  . .... | |. ||.| |  .  |.|||    ||||||
ptrilknlylGsqkdvlseellsklgisyvlnasn.....scpkleelkeskflrvPvkDkydekllpwfdksvefidkak.sengrvlvhvlaGisrsa

VLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEKLME
 ...||.|   .|.. ||   |..|| .| ||  ||.|| | ...|. 
tvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_LRR-DSP_pd Subfamily LRR-DSP 135-279 1.2e-26 87.4 In-house 121-259 (263) alignment 
Range on Protein: 135-279
Range on HMM: 121-259/263.0
DEVWPNVFIAEKSVAVNKGRLKRLGITHIL-NAAHGTGVYtgPEFYtgleiQYLGV-EVDDFPEVDISQHFRKASEFLDEAllTYRGKVLVSSEMGISRS
||. ...|.  .  | ||  || ||.||||   |.   ..  |. .     .|| . ...| .| ||||||..   |..|     .| |||    |.|||
deiidklflGgldsannksilkdlgvthillavadfePlf..Pklf.....kylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhcraGvsrs

AVLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEKLM
. ||..|||  ...   |||  | |||  |.|| ||..||.  ..||.
stlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0048076 (Phosphotyrosine protein) phosphatases II 135-278 1.9e-26 87.9 In-house 5-142 (145) alignment 
Range on Protein: 135-278
Range on HMM: 5-142/145.0
DEVWPNVFIAEKSVAVNKGRLKRLGITHILNAahgtgvYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYrGKVLVSSEMGISRSAV
.|..|....    .|..  .||.||||..||        . .|... | |||| . ..|... |........ ||..|||    |.|||   .|..|...
seilpglylgslptaldlellkdlgittvlnl......tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

LVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNEKL
||.||||. ... . |||  ||..|  . ||.|.|..|.|. ..|
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Slingshot_pd Subfamily Slingshot 135-282 2.4e-21 69.8 In-house 20-161 (169) alignment 
Range on Protein: 135-282
Range on HMM: 20-161/169.0
DEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytgPEFYTGlEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAV
 ...  |..     | |   ||. |...||| ..        .|. . ...|| . | | .| |. ... .. .|...|  .   ||||   ||.|||| 
skifdhvylGsewnasnleelkengveyilnvtkei.....dnffpe.kfeylnirvydeeetdllkywnetykfiekak.kkgskvlvhckmGvsrsas

LVVAYLMIFHNMAILEALMTVRKKRAI-YPNEGFLKQLRELNEKLMEER
 |.|| |  ... . |||  |...| .  ||.||||||.| .  |  ..
tviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileask
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 136-276 1.3e-25 83.6 In-house 9-145 (148) alignment 
Range on Protein: 136-276
Range on HMM: 9-145/148.0
EVWPN-VFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEfytglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAV
|...  .|. .|  | .  .|| ||.|.| ||..               |.|| |..|| |. |.|. | .. .|...|     ..|||  .||.|||. 
eikdafLFlGskksaadlealkalgvtrivnatkerdnaldqr.....gieYlhvaldDkpkedlsaiFediiafvrkak.deGrrvLvhlqmGvsrssa

LVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNE
|....|. |..... |||  |. ||  . || |||||| ||..
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP6_pd Subfamily DSP6 136-279 1.1e-21 71.0 In-house 16-155 (158) alignment 
Range on Protein: 136-279
Range on HMM: 16-155/158.0
EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTyRGKVLVSSEMGISRSAVL
|. |....  .  | |   ||.|.| ..|| ..         |    |..|| . ..|  . .....| .| ||.|||  .   ||||    |||||  .
eilpllylGsakdasnlevlkklkikyvlnvtsnl....pnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.kskvlvhClaGisrsvtv

VVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEKLM
..||||  ..... .|   |.|..  | ||  |..|| . ...| 
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
0037934 (Phosphotyrosine protein) phosphatases II 136-274 3.3e-16 55.0 In-house 41-237 (243) alignment 
Range on Protein: 136-274
Range on HMM: 41-237/243.0
EVWPNVFIAEK--------SVAVNKGRLKRLGITHILNAAHGT----------------------------------------GVY-TGPEFYTGLEIQY
.|.|....            .| .   |..||||.|..  . .                                          . ........  ..|
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

LGVEVDDFPE--VDISQHFRKASEFLDEA----LLTYRGKVLVSSEMGISRSAVLVVAYLMIFH-NMAILEALMTVRKKRA--IYPNEGFLKQLREL
|..   . |.   |. ...... ||..|.     |   |.|||   .|..|...|..||||. . .. ..||. ..|..|   . ........|.|.
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_STYXL1_pd Subfamily STYXL1 137-281 4.7e-20 65.4 In-house 14-156 (157) alignment 
Range on Protein: 137-281
Range on HMM: 14-156/157.0
VWP-NVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVytgpeFYTGLEI--QYLGVEVDDFPEVDISQHFRKASEFLDEALLtYRGKVLVSSEMGISRSA
| | .... . . |.|.   | | .   .| .. ..      ...|..   . | ..|.| .| |. .....| .|...        |||.|. ||||||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk.....liagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsa

VLVVAYLMIFHNMAILEALMTVRK-KRAIYPNEGFLKQLRELNEKLMEE
 ...||||  ....  .|.  ..| |  . || .|..||.| ...|..|
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0049260 (Phosphotyrosine protein) phosphatases II 137-276 1.3e-19 65.8 In-house 11-147 (152) alignment 
Range on Protein: 137-276
Range on HMM: 11-147/152.0
VWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGvytGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLV
.... .. . ..| ..  ||.||||.|..    .     .....   |||| . ..|..  |.||... . .|.....|   |.|||    |..|...||
fiatqgpgpntladfwrmlkelgittivmltelle...lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMIfHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNE
.||||. ... ..||.  ||.||  ..||.|.|..| | ..
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0045450 (Phosphotyrosine protein) phosphatases II 138-274 3.2e-15 52.1 In-house 44-299 (307) alignment 
Range on Protein: 138-274
Range on HMM: 44-299/307.0
WPNVFIAEKSVAVNKGR------------------------------------------------------------------LKRLGITHILNAAHGTG
. .  ||.. .  .| |                                                                  |...|.|.|..  . . 
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

V----------------------YTGPEFYTGLEIQYLGVEVDDF-----------------PEVDISQHFRKASEFLDEALL-----TYRGKVLVSSEM
                        |  ....  ..... .|| |                  |. .....|  . .|..|..      .  |.||| . .
lgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GISRSAVLVVAYLMIFHN--------MAILEALMTVRKKR-AIYPNEGFLKQLREL
|..|......||||. .         . .|||. ..|..|  . .|......|.|.
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 139-277 9.2e-26 84.0 In-house 8-151 (154) alignment 
Range on Protein: 139-277
Range on HMM: 8-151/154.0
PNVFIAEKSVAVNKGRLKRLGITHILNAAHGTG-VYTGP--EFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAL-LTYRGKVLVSSEMGISRSAV
 ...|.    |.||  |.   |..||| . |.  ..|    .   |. |.|| .|. | .. || ... || ||.|.|.    ..|||| |. |.|||| 
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNEK
|...|||   .... .||. ... |  | ||.||||||   . .
llisylmdklkislslalellkdsryiikPnqGflkqleifeke
DSPc Dual specificity phosphatase, catalytic domain 141-276 8.3e-27 88.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 141-276
Range on HMM: 1-132/133.0
VFIAEKSVAVnKGRLKRLGITHILNAAHGTGVYtgpEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYL
.....|| |  .  |. ||||...|... .       ...  ||.||.. |.|. | .||.....|.||...|  . ..||||  ..|||||| |..|||
lylgskstas.lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYl

MIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNE
|  .|. . ||.  |...|  | ||.|||.||.|...
mktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 141-276 8.3e-27 88.7 In-house 1-132 (133) alignment 
Range on Protein: 141-276
Range on HMM: 1-132/133.0
VFIAEKSVAVnKGRLKRLGITHILNAAHGTGVYtgpEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYL
.....|| |  .  |. ||||...|... .       ...  ||.||.. |.|. | .||.....|.||...|  . ..||||  ..|||||| |..|||
lylgskstas.lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYl

MIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNE
|  .|. . ||.  |...|  | ||.|||.||.|...
mktknlslneAyefvkerrskispnagflrqLleyer
subfamily_MKPLT_pd Subfamily MKPLT 144-277 3.7e-18 59.6 In-house 32-159 (164) alignment 
Range on Protein: 144-277
Range on HMM: 32-159/164.0
AEKSVAVNKGRLKRLGITHILNAAHGTGvytgPEFYTglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAVLVVAYLMIF
 . . | |.  || | ||||.| . ..       |     ..|| |.|.| ..  .|... .|..|| .|.    |.|||   .| |||.   ||.|. .
Gnakhatnekvlkdlkithivnvsqekk....dafpk..sveYlqvkvedesdeqlssfleraakfladai.dsGGrvlvhcvqGksrsssvtvafLiks

HNMAILEALMTVRKKRAI-YPNEGFLKQLRELNEK
.   . ||   ....|.|  || |||||| . .| 
kgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 144-277 3.7e-18 59.6 In-house 32-159 (164) alignment 
Range on Protein: 144-277
Range on HMM: 32-159/164.0
AEKSVAVNKGRLKRLGITHILNAAHGTGvytgPEFYTglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAVLVVAYLMIF
 . . | |.  || | ||||.| . ..       |     ..|| |.|.| ..  .|... .|..|| .|.    |.|||   .| |||.   ||.|. .
Gnakhatnekvlkdlkithivnvsqekk....dafpk..sveYlqvkvedesdeqlssfleraakfladai.dsGGrvlvhcvqGksrsssvtvafLiks

HNMAILEALMTVRKKRAI-YPNEGFLKQLRELNEK
.   . ||   ....|.|  || |||||| . .| 
kgwtlkeayeylkerrsivapnrGflkqlakfeel
0040439 (Phosphotyrosine protein) phosphatases II 145-274 6.8e-17 57.4 In-house 64-241 (249) alignment 
Range on Protein: 145-274
Range on HMM: 64-241/249.0
EKSVAVNKGRLKRLGITHILNAAHGTGV--YTGPEF-----------------------------------YTGLEIQYLGVEVDDFPEVDISQHFRKAS
...|. .   |..||||.|... . .     .  ..                                   |.| ....|.. . |.|. .....|  . 
petvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedll

EFLDEALL-----TYRGKVLVSSEMGISRSAVLVVAYLM-----IFHNMAILEALMTVRKKR-AIYPNEGFLKQLREL
.|.....         |.||| . .|..|......||||       ... ..||. ..|..|  . .|......| |.
dfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 149-281 5.9e-18 58.4 In-house 14-144 (145) alignment 
Range on Protein: 149-281
Range on HMM: 14-144/145.0
AVNKGRLKRLGITHILNAAHGTGVYTgPEFYtGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGkVLVSSEMGISRSAVLVVAYLMIFHNMAI
| .   |. |||. |.| | |  | .  | . . .|. | .  .|.   |.|||| . ..|.|       | |.|    |.|||  . ||.|| . ||..
andvptlqelgisrivnmaagslvas.qelk.sesieillitaedlesydlsqhfdevtdfidkgkeegag.vfvhcmagvsrsvtvsvaflmkycnmtl

LEALMTVRKKRA-IYPNEGFLKQLRELNEKLMEE
 ||   || .|   |||  |||.| .|. .| ||
seaarqvrsnrllaypnvtflknllnlekqlkee
0039614 (Phosphotyrosine protein) phosphatases II 149-273 4.7e-12 41.5 In-house 56-283 (297) alignment 
Range on Protein: 149-273
Range on HMM: 56-283/297.0
AVNKGRL-----------------------------------------------------------KRLGITHILNAAHGTGV-----------------
 ..| |                                                            ...|.|.|..    .                   
nkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygd

----YTGPEFYTGLE-----------------IQYLGVEvdDFPEVDISQHFRKASEFLDEALLT--YRGKVLVSSEMGISRSAVLVVAYLM-----IFH
    ... | . |                   .||.|    |.   ...... .. |...||| .    |.||| . .|..|......||||       .
ftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeg

NMAILEALMTVRKKR-AIYPNEGFLKQLRE
.. .|||. ..|..|  . ........|..
gvdvleavkelreqRpgavqtpsqyrflyd
0038934 (Phosphotyrosine protein) phosphatases II 150-279 1.5e-12 43.1 In-house 47-177 (194) alignment 
Range on Protein: 150-279
Range on HMM: 47-177/194.0
VNKGRLKRLGITHILNAAHGTGVYtGPEFYTGLEIQYLGVEVDDF---PEVDISQHFRKASEFLDEAllTYRGKVLVSSEMGISRSAVLVVAYLMIFHNM
|.  .|.  .......  . . .|  || .... |.||   . |.   |  .| ..| .. ..  ..     |.|.|   .|..|...||.|||.  ..|
vrylkllnvklglvidltnteryY.dpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm

AILEALMTVRKKR-AIYPNEGFLKQLRELNEKLM
   ||. ..| ||  ..|| ..|..|..  . |.
saeeAialfrekRpgaipnqdyleallkrykelr
0051429 (Phosphotyrosine protein) phosphatases II 150-278 7.4e-11 37.7 In-house 36-224 (272) alignment 
Range on Protein: 150-278
Range on HMM: 36-224/272.0
VNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDIS-------------------------------------------------
 .  |||.|||..|..  . . .   . ..    |.|| . . |. . .|.                                                 
adfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgv

--QHFRKASEFLDEalltyRGKVLVSSEMGISRSAVLVVAYLMIfHNMA--------------ILEALMTVRKKR-AIYPNEGFLKQLRELNEKL
  . .... |.| .      |.|||    |..|....|...|.. ...               ..||.  .|..| .. ..|.....|.|   .|
pqeallellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 156-274 1.6e-12 42.8 In-house 107-271 (317) alignment 
Range on Protein: 156-274
Range on HMM: 107-271/317.0
KRLGITHILNAAHGTGVY---------------------TGPEFYTGLEIQYLGVEVDDF----------------PEVDISQHFRKASEFLDEALLT--
...|.|.|..  . .                        |  ....  .|... .|| |                 |. .. ....   .||...     
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

-YRGKVLVSSEMGISRSAVLVVAYLM-----IFHNMAILEALMTVRKKRA-IYPNEGFLKQLREL
   |.||| . .|..|......||||       ... . ||. ..|..|. . ........| ..
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 158-273 3.4e-11 38.6 In-house 111-271 (278) alignment 
Range on Protein: 158-273
Range on HMM: 111-271/278.0
LGITHILNAAHGTGVY-----------------------------------------TGPEFYTGLEIQYLGVEVDDFPEvDISQHFRKASEFLDEALlT
||.|.|..    .                                              .| .|.. ..|||.  ...|| ..|....   ....    .
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreale.d

YRGKVLVSSEMGISRSAVLVVAYLM-----IFHNMAILEALMTVRKKR-AIYPNEGFLKQLRE
  |.||| .  |..|.......||.       ... ..||. ..|..|  . ... ....|.|
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 177-260 4.5e-07 25.1 In-house 180-266 (288) alignment 
Range on Protein: 177-260
Range on HMM: 180-266/288.0
EFYTGLEIQYLGVEvdDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLM-----IFHNMAILEALMTVRKKRA
| .|   ..|..    |.   |  ... .  .....||    | |.| .  |..|........|.       . . .|||. ..|..| 
esrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp
0046845 (Phosphotyrosine protein) phosphatases II 177-260 6.2e-07 24.5 In-house 163-254 (284) alignment 
Range on Protein: 177-260
Range on HMM: 163-254/284.0
EFYTGLEIQYLGVEVDDFPE--VDISQHFRKASEFLDEalLTYRGKVLVSSEMGISRSAVLVVAYLMIFH--------NMAILEALMTVRKKRA
| .|   ..|..   .. |.   |. . .|.. |.|..  | . |...| .  |..|........|.. .        .. .|||.  .|..| 
esrtvthfhytswpdhgvppspedlleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
subfamily_PTPMT1_pd Subfamily PTPMT1 179-261 5.2e-08 27.5 In-house 69-150 (171) alignment 
Range on Protein: 179-261
Range on HMM: 69-150/171.0
YTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAI
.. | ...| ... || |    ..  |. ||...   .   .| |  . | .||| || .|||  ...   ||| ...||| |
wkklgveqlqlatvDfteapdleklekgvefiekva.skgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki
0047943 (Phosphotyrosine protein) phosphatases II 179-260 3.3e-07 25.5 In-house 166-252 (273) alignment 
Range on Protein: 179-260
Range on HMM: 166-252/273.0
YTGLEIQYLGVEVDDFPEvdISQHFRKASEFLDEALLT--YRGKVLVSSEMGISRSAVLVVAYLM-----IFHNMAILEALMTVRKKRA
.|   ..|.|   .. |.    ... .  |....|| .    |.|.| .  |..|........|.       ... .|||.  .|..| 
rtvthfhytgwpdhgvpp..slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRp
subfamily_MSG5_pd Subfamily MSG5 215-278 3e-09 30.2 In-house 96-160 (165) alignment 
Range on Protein: 215-278
Range on HMM: 96-160/165.0
LTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKK-RAIYPNEGFLKQLRELNEKL
 . | |.||  . |.|||| |.|||.| ..|... .|   .. .   | |. |.. || | .  |
tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval