Gene DUSP3 in Homo sapiens

Synonym: VHR, DUSP3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP028_AA protein Get Run
HsapP028_AA_27-181 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 20-184 2.7e-47 156.0 In-house 13-177 (178) alignment 
Range on Protein: 20-184
Range on HMM: 13-177/178.0
SGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGR
.|. . .  ...|..|..|.|..  |.|.. |..|||||..| .|    ....... .... ||.|| |   |  ...|...|... .||..||..|.|.
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggp

VLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLK
|||||. |..||.|||.||||....... .|.. ||. | | ||.|.| ||...  || ||..|.
vlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkesdll
subfamily_DSP3_pd Subfamily DSP3 22-180 7.2e-75 244.1 In-house 3-160 (162) alignment 
Range on Protein: 22-180
Range on HMM: 3-160/162.0
CYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGrSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVL
...|.|. ..||.|..|||...||.|  ||.||||||||||||| .|..|.|.|.||||..|.|||....|..||.||.|||.||.|||.||.||.|.||
lerllskevdevypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvl

VHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKE
|||..|.|||.|||.||||.|.||....|.. ||..|||.||.|||.||..|...|...
vhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkrk
PTEN_1 22-178 1.2e-34 114.9 In-house 35-192 (196) alignment 
Range on Protein: 22-178
Range on HMM: 35-192/196.0
CYSLPSQPcnEVTPRIYVGNASVA-QDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQK-NGR
..|.| .   |. .. |.|... . .|   |.. |||.|.| .|..  . .. . .....||..|| .  .| .  .||  |. ...||...|... .. 
apsrpllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnv

VLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQLNDRLA
|||||. | .|| |.|.|||| ..|.... ||..||. |  ..|| ... .| .  ..| 
VlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
subfamily_DSP8_pd Subfamily DSP8 22-178 2.6e-28 92.6 In-house 7-155 (159) alignment 
Range on Protein: 22-178
Range on HMM: 7-155/159.0
CYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAegrsfmHVNTNANFYKDSGitYLGIKANDTQEFNLSAYFERAADFIDQALaQKNGRVL
| | ..   ..... .|.|   .. .   |.||||..||||       .   . .. |.|   .| .  .|... .|. .|... .|||.|  ..|||||
CLsvadvgptrilknlylGsqkdvlseellsklgisyvlnas......nscpkleelkesk..flrvPvkDkydekllpwfdksvefidkak.sengrvl

VHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQLNDRLA
||.  | |||.|..|||.| . .|.. .|   |.. |  | ||  || || . . .| 
vhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0036941 (Phosphotyrosine protein) phosphatases II 22-177 2e-19 65.4 In-house 11-276 (297) alignment 
Range on Protein: 22-177
Range on HMM: 11-276/297.0
CYSLPSQPCNEVTPRIYVGNASVAQDIPKLQ----------------------------------------------------------KLGITHVLNAA
...| .. . |..|... |. |||.    |.                                                          ....|....  
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

EGRS---------FMHVNTNANFYKDSGITYLGIKA-----------------------------NDTQEFNLSAYFERAADFIDQALA-----QKNGRV
|  .         . . . .   |.|  .|.|...                               .  ....  ...   |||....       ..|.|
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

LVHCREGYSRSPTLVIAYLM--------MRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQLNDRL
||||. | .|| |...|.||        .....|...|.  .|. |  . .. ... .|...   |
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 24-174 6.9e-30 99.8 In-house 16-268 (278) alignment 
Range on Protein: 24-174
Range on HMM: 16-268/278.0
SLPSQPCNEVTPRIYVGNAS-----------------------------------------VAQDIPKLQKLGITHVLNAAEG-----------------
 |.  . .|.|| .|.||..                                         ||...  |..||||......|                  
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

---------------------RSFMHVNT--NANFYKDSGITYL---GIKANDTQEFNLSAYFERAADFIDQALAQ-------------KNGRVLVHCRE
                     | .. .|.  . . ..  |.|.|   ..  ... .......| .. .||..||..             ..|.|||||. 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GYSRSPTLVIAYLMMRQ---KMDVKSALSIVRQNRE--IGPNDGFLAQLCQLN
| .|. |||.||||...   ..|. .|.. .|. |   . .| ... .|... 
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefl
subfamily_DSP10_pd Subfamily DSP10 27-180 3.3e-35 115.3 In-house 11-156 (159) alignment 
Range on Protein: 27-180
Range on HMM: 11-156/159.0
SQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAegrsfmhvNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCRE
..|  .| | ...|..  |.|.  |..|.||.||| .        ..  |........|  |...||.. ||. ||| | .||..|  .|. ||||||. 
tapasqvlpfLflGsekdaadldaldrlnitavlnvt........tsvPnefeeealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqa

GYSRSPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDRLAKE
| ||| |.|||||| .... .. |   |...|  | || .|. || .....|.|.
GisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
0046846 (Phosphotyrosine protein) phosphatases II 27-177 1.3e-30 101.9 In-house 9-172 (176) alignment 
Range on Protein: 27-177
Range on HMM: 9-172/176.0
SQPCNEVTPRIYVGNAS----------VAQDIPKLQKLGITHVLNAAEGRSFMHV--NTNANFYKDSGITYLGIKANDTQEFNLsAYFERAADFIDQALA
  ...........|..           .|...  |..||||.|.|  | . . ..   .  . ... ||.|| .   | .  .| ...... .||..|| 
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

QKnGRVLVHCREGYSRSPTLVIAYLMMR-QKMDVKSALSIVRQNR--EIGPNDGFLAQLCQLNDRL
.. |.|||||. | .|..|||.|||... . ..|  ||. ||. |   . ...... .| .   .|
eg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP1_pd Subfamily DSP1 28-178 6.9e-36 117.8 In-house 16-157 (163) alignment 
Range on Protein: 28-178
Range on HMM: 16-157/163.0
QPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEgrsfmhvnTNANFYKDsGITYLGIKANDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCREG
.| ..... .|.| ..|| .   |..||||..||...        .  |...|   .|  .| .|... ..|..||.. .|||..  .|||.||.||. |
dPvekildfLylGsetvasnleiLkslgitailnvsk........eldnvfed.lfeYkklkleDspkadislvfeeviefidev.kkknGkvlihCqaG

YSRSPTLVIAYLMMRQKMDVKSALSIVRQNREI-GPNDGFLAQLCQLNDRLA
 ||| ||..||||..... .. |   |.|.|.|  || ||  || . . .| 
isRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP14_pd Subfamily DSP14 28-180 1.3e-30 100.4 In-house 5-147 (157) alignment 
Range on Protein: 28-180
Range on HMM: 5-147/157.0
QPCNEVTPRIYVGnASVAQDIPKLQKLGITHVLNAAEgrsfmhvNTNANFYKdsGITYLGIKANDTQEFNLSAYFERAADFIDQaLAQKNGRVLVHCREG
. ....|| .... ...|..  .|.| .||...|..        ..... .|  .| .. ....|..| .|...|...|| |.. . .|.|..||||  |
aalsqitpsLfls.gvaalskellkkkkitliinvtv.......elpntklk..diervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCvaG

YSRSPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDRLAKE
 ||| .|..||||  .|.  . | ..|.. |  | || ||  || ..  .| ..
vSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
subfamily_STYXL1_pd Subfamily STYXL1 28-179 6.4e-19 61.7 In-house 10-155 (157) alignment 
Range on Protein: 28-179
Range on HMM: 10-155/157.0
QPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFmhvntN-----AnfykdsGITYLGIKANDTQEFNLSAYFERAADFIDQALAqKNGRVLV
 | . .  ..|.|| . ||.    . | .  ..| .                           | |. .|..| .|   ...| .||..    ..  |||
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk.....liagvad......vakllhiavedeneadllerlkeavqfiekhkk.egevvlv

HCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDRLAK
   .| ||| ...|||||  .|.  |.|.. ... .| . || .|. || . ...| .
fsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
0041856 (Phosphotyrosine protein) phosphatases II 29-177 2.4e-34 113.9 In-house 18-172 (182) alignment 
Range on Protein: 29-177
Range on HMM: 18-172/182.0
PCNEVTPRIYVGNASV--------------AQDIPKLQKLGITHVLNAAegrsfmHVNTNANFYKDSGITYLGIKANDTQEFNlsayFERAADFIDQALA
.........|.|.                 |.... |..||||...|..       .. ....... ||.|| .   |   ..    .. . |||...|.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

qKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNRE---IGPNDGFLAQLCQLNDRL
 ..|.|||||. | .|..|||.||||....... .|.. ||. |    | || .|. ||. |  .|
.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
PTPc_motif_SM00404 30-174 1.4e-42 139.9 In-house 2-138 (140) alignment 
Range on Protein: 30-174
Range on HMM: 2-138/140.0
CNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMhvntnanfYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCREGYS
.....|..|.|..| ||. ..|.|||||||.|..|  |          ...||...| |. .|... .||.|.....|||..| ..|.|.|||||. |.|
psrilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvS

RSPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLN
|| ||.|||||.........|...|...|. | || .|..||....
RSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP19_pd Subfamily DSP19 30-176 1.8e-38 126.3 In-house 12-149 (152) alignment 
Range on Protein: 30-176
Range on HMM: 12-149/152.0
CNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAegrsfmhVNTNANFYKDsgITYLGIKANDTQEFNLSAYFERAADFIDQALAQKnGRVLVHCREGYS
  ||.||.|.|  .||.|  .|.. .|||.|| |       ....  | ||  .||| |.  |..| .|..|...| |||..|. .. |.|||||. | |
vgeveprlylgsqdvaadkeilkekkitHilnva.......tgvpnvfpkd..ftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvS

RSPTLVIAYLMMRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQLNDR
||...|||||| ........||. ||. |  | ||.||. ||.... .
RsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
0036282 (Phosphotyrosine protein) phosphatases II 30-175 2.5e-30 100.9 In-house 12-167 (174) alignment 
Range on Protein: 30-175
Range on HMM: 12-167/174.0
CNEVTPRIYVGNASVAqDIPKLQKLGITHVLNAAEGRSFM------HVNTNANFYKDSGITYLGIKANDTQEFNLSAyFERAADFIDQALAQ-KNGRVLV
 ...|||...|..  | ... |..||||.|..  | .           ... ......||.|| .   | ....||  .... .|...||.. ..| |||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCREGYSRSPTLVIAYLMMRQKM-DVKSALSIVRQNR----EIGPNDGFLAQLCQLND
||. | .|..|||.||||.|... ..  ||..||. |     . ...... .| ....
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0051082 (Phosphotyrosine protein) phosphatases II 30-172 2.7e-30 100.3 In-house 8-148 (151) alignment 
Range on Protein: 30-172
Range on HMM: 8-148/151.0
CNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMhvnTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYS
.. ||...|....  |.... |..|||....|  .        ........ ||..| |   |.....|. .|. ...|....|..||| |||||. | .
fsyvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkg

RSPTLVIAYLMMrQKMDVKSALSIVRQNRE--IGPNDGFLAQLCQ
|. |||..|||. ..... .||. .|. |   . ||..|| ||..
RTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 30-175 2.9e-29 97.1 In-house 8-147 (152) alignment 
Range on Protein: 30-175
Range on HMM: 8-147/152.0
CNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFykdsgiTYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYS
 .|... ...|. ..|...  |..||||....  |   . .. ..  .      .|| .   |    .|| ... . .||.... .|.|.|||||. | .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

RSPTLVIAYLMMrQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLND
|..|||.||||. ...... |.. ||. |  . || |.| .| . ..
Rtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_STYX_pd Subfamily STYX 30-174 2.7e-23 75.9 In-house 12-154 (166) alignment 
Range on Protein: 30-174
Range on HMM: 12-154/166.0
CNEVTPRIYVGNASVAQ--DIPKLQKLGITHVLNAAEGRSFMHVNtnANFYKDsgITYLGIKANDTQEFNLSAYFERAADFIDQALaQKNGRVLVHCREG
 .|. | ...|  | |.   ...|.| ||||..   .      .    || ..  . || .   |.   |.  |. .  .|||..| || |.||||   |
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlik..pnfpdr..frylvldvadntveniirylptvkefiddsl.qkggkvlvhgnag

YSRSPTLVIAYLMMRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQLN
 ||| .|||||.|    .  ..|   |...|  | ||.||  || . .
isrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0042113 (Phosphotyrosine protein) phosphatases II 30-171 8.8e-23 76.4 In-house 47-236 (245) alignment 
Range on Protein: 30-171
Range on HMM: 47-236/245.0
CNEVTPRIYVGNASVAQDIP----KLQKLGITHVLNAAEGRSF-------------------------------------MHVNTNANFYKDSGITYLGI
. ..||.......  .....     |..||||....  |   .                                     ..|  . ....  .|.|. .
gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

KANDTQEFNLSAYFERAADFIDQALA-QKNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR-EIGPNDGFLAQLC
   | .. .|....... .|...|||  .||.|||||. | .|. |...||||      ...... .|.  .|. |  . ...... .| 
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0048076 (Phosphotyrosine protein) phosphatases II 31-176 5.4e-35 115.5 In-house 5-141 (145) alignment 
Range on Protein: 31-176
Range on HMM: 5-141/145.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAaegrsfmhvNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKnGRVLVHCREGYSR
.|..|..|.|.  .|.|.. |..||||.|||           .. ..... ||.|| .   | ....|....... .||..||... |.|||||. |..|
seilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgR

SPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDR
..|||.||||....... .||  ||. |  . ||.|.| .|...  .
tgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 31-176 9.9e-35 114.7 In-house 5-143 (144) alignment 
Range on Protein: 31-176
Range on HMM: 5-143/144.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRsfmhvntNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAqKNGRVLVHCREGYSR
.|..|..|.|.  .|.|.. |.|||||.|.| .|..         .|... ||.|| .   | . ..|....... .||..||. ..|.|||||. |..|
seilpglylgslptaldlellkklgittvinlteey.......epefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgR

SPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDR
..|||.||||.........||  ||. |  . ||.|.| .|......
tgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP12_pd Subfamily DSP12 31-170 1.2e-33 110.7 In-house 3-136 (155) alignment 
Range on Protein: 31-170
Range on HMM: 3-136/155.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSfmhvntNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALaQKNGRVLVHCREGYSR
....|..|.|... .|. ..|..|.|||||  .. .       .    | . .... |.. |..| ..  ....| |||..|| ...| |||||  | ||
srilpglylggleavqeeellkelkithvlsvikeel......pehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSR

SPTLVIAYLMMRQKMDVKSALSIVRQ-NREIGPNDGFLAQL
| |.|||||| ..|.....||..|.. ..|| ||.|||.||
SvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL
subfamily_DSP6_pd Subfamily DSP6 31-178 5.2e-32 104.5 In-house 15-155 (158) alignment 
Range on Protein: 31-178
Range on HMM: 15-155/158.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEgrsfmhvNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAqKNGRVLVHCREGYSR
 |..|..|.|.|  |...  |.||.| .||| ..       | .  | ..  ..|| | ..|  . ||...|  | .|||.|   |.  |||||  | ||
veilpllylGsakdasnlevlkklkikyvlnvts.......nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidears.kkskvlvhClaGisr

SPTLVIAYLMMRQKMDVKSALSIVRQN-REIGPNDGFLAQLCQLNDRLA
| |...|||| .... ...|  .|..   .| ||  |. || . . .| 
svtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
0043147 (Phosphotyrosine protein) phosphatases II 31-177 1.4e-31 104.9 In-house 20-160 (172) alignment 
Range on Protein: 31-177
Range on HMM: 20-160/172.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGrsfmhvNTNANFYKDSGITYLGIKANDTQEFnLSAYFERAADFIDQ-ALAQKNGRVLVHCREGYS
... .  ....  .|...  |..|||||..|. |        ... .....||.|| .   |   . |....... .|||. .. ...|.|||||. | .
drfiatqgplrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvg

RSPTLVIAYLMMrQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDRL
|..|||.||||. .....  |.. ||. |  . .|.... .|......|
Rtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 31-178 2.3e-31 102.9 In-house 121-259 (263) alignment 
Range on Protein: 31-178
Range on HMM: 121-259/263.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAaegrsfmhVNTNANFYKDSgITYLGI-KANDTQEFNLSAYFERAADFIDQAlaQKNGRVLVHCREGYS
.|. .....|    |.. . |..||.||.| |        |     .. .    || | ...|..|...| .||.   ||..   .|.| |||||| | |
deiidklflGgldsannksilkdlgvthilla........vadfePlfPkl.fkylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhcraGvs

RSPTLVIAYLMMRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQLNDRLA
|| ||||.|||..|..  | || .| ..| .| || ||. || . .  | 
rsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP15_pd Subfamily DSP15 31-180 2.4e-31 102.9 In-house 3-142 (151) alignment 
Range on Protein: 31-180
Range on HMM: 3-142/151.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEgrsfmhvnTNANFYKDsgITYLGIKANDTQEFNLSAYFERAADFIDQALAqKNGRVLVHCREGYSR
..| | .|.||  ...|  .|..  |||.|.  .         . .. ||  |.|. |.|.|| . .|| .|. . .|| ..   |.. |||||  | ||
skvlpglylgnfrdskdeelLkeknithilsvhd........nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRl.keenvlvhClaGvsR

SPTLVIAYLMMRQKMDVKSALSIVRQNREI-GPNDGFLAQLCQLNDRLAKE
| |||.||||   ... . ||......| .  || ||  || . .   .||
svtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 31-175 2.9e-28 92.2 In-house 4-150 (154) alignment 
Range on Protein: 31-175
Range on HMM: 4-150/154.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQAL-AQKNGRVLVHCREGYS
. ..  .|..    | .  .||.  |...|| . | . .  . |..      | || ..  |  .|..   ...| .|||.|. . .|..||||. .| |
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSPTLVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLND
|| .|.|.||| ..|. .  || .... |  | || ||| ||.. . 
rsaallisylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_Slingshot_pd Subfamily Slingshot 31-174 7.2e-26 84.6 In-house 20-154 (169) alignment 
Range on Protein: 31-174
Range on HMM: 20-154/169.0
NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEgrsfmhvnTNANFYKDSgITYLGIKANDTQEFNLSAYFERAADFIDQALAqKNGRVLVHCREGYSR
 ..   .|.|    | .. .|.. |....|| ..           ||.... ..|| |.  |..| .| .|.... .||..| . |. .|||||. | ||
skifdhvylGsewnasnleelkengveyilnvtk........eidnffpek.feylnirvydeeetdllkywnetykfiekakk.kgskvlvhckmGvsr

SPTLVIAYLMMRQKMDVKSALSIVRQNREI-GPNDGFLAQLCQLN
| . |||| | . ......||. |...|..  ||.||| || . .
sastviayamkeyglsleealeyvkerrsvikPnkgflkqleeye
0037934 (Phosphotyrosine protein) phosphatases II 31-172 1.8e-23 78.8 In-house 40-236 (243) alignment 
Range on Protein: 31-172
Range on HMM: 40-236/243.0
NEVTPRIYVGNA--------SVAQDIPKLQKLGITHVLNAAEGR------------------------------------SFMHVNTNANFYKDSGITYL
 .||||......         .|...  |..||||....  |                                       .. .|.... ..  .| |.
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

GIKAND----TQEFNLSAYFERAADFIDQA----LAQKNGRVLVHCREGYSRSPTLVIAYLMMRQ-KMDVKSALSIVRQNRE--IGPNDGFLAQLCQ
 .   |    .   .| .... . .||...     . ..|.|||||. | .|. ||..||||... ..|. .|.  .|. |   . .. ... .| .
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye
subfamily_PTPMT1_pd Subfamily PTPMT1 32-160 1.5e-20 68.3 In-house 22-150 (171) alignment 
Range on Protein: 32-160
Range on HMM: 22-150/171.0
EVTPRIYVGNASVAQDIPKL-QKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNgRVLVHCREGYSR
 .   ...|   . ..| .| .|  .  |..  |   . ..  . . .|  |...| ..  |  |    .  |.. .||..   ... || |||. | .|
riDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgk.rvYvHCkaGrgR

SPTLVIAYLMMRQKMDVKSALSIVRQNREI
| |||..|||...|.. ..||..... |.|
satlvacylmkkeklspeeAlkalkkkRki
Y_phosphatase2 Tyrosine phosphatase family 32-139 7.9e-06 17.8 Pfam-A 9-112 (165) alignment 
Range on Protein: 32-139
Range on HMM: 9-112/165.0
EVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFmhvNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRS
.| . .| .  . |.  . |..| .  ..   .       . . .| .   | .. |.... .|   .   ..    .   | ..|  ||.|| .|  | 
aveselyrssyprasnfsflksLkLktiislspeees...qdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrGkhrt

pTLVIAYL
  |||. |
.glvigcl
0049772 (Phosphotyrosine protein) phosphatases II 34-177 3.6e-33 111.0 In-house 120-273 (314) alignment 
Range on Protein: 34-177
Range on HMM: 120-273/314.0
TPRIYVG-----------------------------NASVAQDIPKLQklgithvlnaaegrsfmHVNTNANFYKDSGITYLGIKANDtQEFNLSAYFER
 .|. |.                             |  .|.|.. |.                  . ........ ||.|| |   |  ...|...|..
nvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.................eelydpelferlgikylripvpD.gsaplledfde

AADFIDQAlaQKNGRVLVHCREGYSRSPT-LVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRL
. .||..|  .|.|.|||||. | .|..| .|.||||........ ||. ||. | |.||.||. ||.|.  .|
flefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefil
subfamily_MKPLT_pd Subfamily MKPLT 34-174 2.3e-24 79.8 In-house 26-157 (164) alignment 
Range on Protein: 34-174
Range on HMM: 26-157/164.0
TPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRsfmhvntNANFYKdsGITYLGIKANDTQEFNLSAYFERAADFIDQALaQKNGRVLVHCREGYSRSPT
  ..| |||. |..   |..| |||..| ....       . .| |   . || .| .|. . .||...||||.|. .|. .  |||||||  | ||| .
edtlylGnakhatnekvlkdlkithivnvsqek.......kdafpk..sveYlqvkvedesdeqlssfleraakfladai.dsGGrvlvhcvqGksrsss

LVIAYLMMRQKMDVKSALSIVRQNREI-GPNDGFLAQLCQLN
  .|.|.  ..  .| | . ... | |  || ||| ||.. .
vtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 34-174 2.3e-24 79.8 In-house 26-157 (164) alignment 
Range on Protein: 34-174
Range on HMM: 26-157/164.0
TPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRsfmhvntNANFYKdsGITYLGIKANDTQEFNLSAYFERAADFIDQALaQKNGRVLVHCREGYSRSPT
  ..| |||. |..   |..| |||..| ....       . .| |   . || .| .|. . .||...||||.|. .|. .  |||||||  | ||| .
edtlylGnakhatnekvlkdlkithivnvsqek.......kdafpk..sveYlqvkvedesdeqlssfleraakfladai.dsGGrvlvhcvqGksrsss

LVIAYLMMRQKMDVKSALSIVRQNREI-GPNDGFLAQLCQLN
  .|.|.  ..  .| | . ... | |  || ||| ||.. .
vtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfe
0039614 (Phosphotyrosine protein) phosphatases II 35-173 1.1e-19 66.5 In-house 101-284 (297) alignment 
Range on Protein: 35-173
Range on HMM: 101-284/297.0
PRIYVGNASVAQD----IPKLQKLGITHVLNAAEGRSFMHvN-----------------TNANFYKDSGIT-------------------YLGIKanDTQ
.....  .   .     .  ....|.|....  .     .                   |. ......|.|                   |.|.   | .
rkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhg

EFNLSAYFERAADFIDQALAQ--KNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQL
  ...... .. .....|||.  |.|.|||||  | .|. |...||||      ....||..|.. .|. |  . ...... .|...
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0038934 (Phosphotyrosine protein) phosphatases II 35-175 5e-18 60.9 In-house 36-174 (194) alignment 
Range on Protein: 35-175
Range on HMM: 36-174/194.0
PRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMhvntNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQK-NGRVLVHCREGYSRSPT
. .|. . .   .  ||.. ....|..  .   .     ... ....||.|| .   |  .    .   |  |..|. |... .| |.|||  |..|..|
eelyrfspedlvrylkllnvklglvidltnteryY....dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGt

LVIAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLND
||.|||..|..|... |. ..|. |  . || ..| .|..  .
lvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 36-175 1.8e-29 96.1 In-house 14-145 (148) alignment 
Range on Protein: 36-175
Range on HMM: 14-145/148.0
RIYVGNASVAQDIPKLQKLGITHVLNAAEGRSfMHVNTNanfykdsGITYLGIKANDTQEFNLSAYFERAADFIDQALAQkNGRVLVHCREGYSRSPTLV
 ...|.   | |. .|..||.|.. ||.. |  . ..         || || .. .| ....|||.|| ...|...| ..  .|||||.. | |||  |.
fLFlGskksaadlealkalgvtrivnatkerd.naldqr.......gieYlhvaldDkpkedlsaiFediiafvrkakde.GrrvLvhlqmGvsrssala

IAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLND
...|.  ... .| || .|...|. . || ||| || .|..
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 36-180 2.9e-24 78.8 In-house 5-144 (145) alignment 
Range on Protein: 36-180
Range on HMM: 5-144/145.0
RIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFmhvnTNANFYkDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGrVLVHCREGYSRSPTLV
|.||| |  |.|.| ||.|||. ..| | | .     .  . .    |. | | |.| . ..|| .|.  .||||.   .  | |.|||  | ||| |. 
rlyvgsalhandvptlqelgisrivnmaagslv....asqelk.sesieillitaedlesydlsqhfdevtdfidkgkeegag.vfvhcmagvsrsvtvs

IAYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLNDRLAKE
.|.||   .| .  |   || ||    ||  || .| .|. .| .|
vaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
0051429 (Phosphotyrosine protein) phosphatases II 36-173 2.3e-18 62.3 In-house 22-220 (272) alignment 
Range on Protein: 36-173
Range on HMM: 22-220/272.0
R-IYVGNAS---VAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFykdSGITYLGIKANDTQEFNLSAYF-----------------------------
. .| ...     |.|...|..|||.....  .     ....        ||.|| .  .|. ..  . ..                             
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------ERAADFIDQALAqkNGRVLVHCREGYSRSPTLVIAYLMMrQKMD--------------VKSALSIVRQNR-EIGPNDGFLA
                   |   ..... |.  .|.|||||. | .|. |.| ..|.. . ..              .  |.. .|. |  .........
arevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLCQL
.|.. 
flyea
DSPc Dual specificity phosphatase, catalytic domain 37-175 5e-41 134.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 37-175
Range on HMM: 1-132/133.0
IYVGNASVAQdIPKLQKLGITHVLNAAEGRSFMhvntnaNFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCREGYSRSPTLVI
.|.|..| |.  ..|.|||||.|.|...  .        |..|.| |.||.|. .|..| ..|...|.| .||..| .||...|||||. |.|||.||.|
lylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii

AYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLND
||||.........|...|...|. | ||.|||.||.....
aYlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 37-175 5e-41 134.7 In-house 1-132 (133) alignment 
Range on Protein: 37-175
Range on HMM: 1-132/133.0
IYVGNASVAQdIPKLQKLGITHVLNAAEGRSFMhvntnaNFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCREGYSRSPTLVI
.|.|..| |.  ..|.|||||.|.|...  .        |..|.| |.||.|. .|..| ..|...|.| .||..| .||...|||||. |.|||.||.|
lylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii

AYLMMRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQLND
||||.........|...|...|. | ||.|||.||.....
aYlmktknlslneAyefvkerrskispnagflrqLleyer
0040439 (Phosphotyrosine protein) phosphatases II 41-173 1.3e-22 76.1 In-house 64-241 (249) alignment 
Range on Protein: 41-173
Range on HMM: 64-241/249.0
NASVAQDIPKLQKLGITHVLNAAEGRSF------------------------MHVNTNANF----------YKDSGITYLGIKANDTQEFNLSAYFERAA
. .|. ..  |..||||..... .   .                        ..|......          |... .|.|.|   |  ..... .|| . 
petvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedll

DFIDQALA-----QKNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR-EIGPNDGFLAQLCQL
|||....       |.|.|||||  | .|..|...||||      ....|...|.. .|. |  . .|.... .|...
dfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
subfamily_PRL_pd Subfamily PRL 43-163 2e-06 22.0 In-house 22-135 (151) alignment 
Range on Protein: 43-163
Range on HMM: 22-135/151.0
SVAQDIPKLQKLGITHVLNAAEgrsfmhVNTNANFYKDSGITYLGIKANDTQEfNLSAYFERAADFIDQALAQKNG-RVLVHCREGYSRSPTLViAYLMM
.. . | .|.| ....|  . |      .. ...  ...||. | .. .| .    ..  |.  . . .. .....  | |||  |  |.| || |  ..
tlekfieelkkeevktvvrvce......ptydteklekegievldlafddGav.PpeevveeWlellkekfkeepkstvavhcvaGlGraPvlv.alali

RQKMDVKSALSIVRQNREIGPN
 . |. . |....|..|    |
eaGmkyedavefirekrrgain
0045450 (Phosphotyrosine protein) phosphatases II 49-173 1.5e-22 76.2 In-house 125-299 (307) alignment 
Range on Protein: 49-173
Range on HMM: 125-299/307.0
PKLQKLGITHVLNAAEGRSF--------------------MHVnTNANFYKDSGITYLGIKANDT-----------------QEFNLSAYFERAADFIDQ
  |...|.|....  |   .                    ..| |. ......|.|.. ..  |.                  ..... .|| . |||..
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftv.tllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

ALA-----QKNGRVLVHCREGYSRSPTLVIAYLMMRQK--------MDVKSALSIVRQNR-EIGPNDGFLAQLCQL
...     .|.|.|||||. | .|..|...||||.||         .|. .|.. .|. |  . .| ... .|...
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 51-173 1.9e-18 62.3 In-house 106-271 (317) alignment 
Range on Protein: 51-173
Range on HMM: 106-271/317.0
LQKLGITHVLNAAEGRSFMHVN------------------TNANFYKDSGITYLGIKANDT----------------QEFNLSAYFERAADFIDQALAQ-
....|.|....  |   .  ..                  |. ......|||.. ..  |.                 ....  ...   ||.... .. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

--KNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNRE-IGPNDGFLAQLCQL
  ..| |||||  | .|. |...||||      ....||..|.  .|. |  . .. ... .|...
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 51-158 5.5e-15 51.0 In-house 108-256 (278) alignment 
Range on Protein: 51-158
Range on HMM: 108-256/278.0
LQKLGITHVLNAAEGRSFMHVN--------------------------------------TNANFYKDSGITYLGIKANDTQEfNLSAYFERAADFIDQA
...||.|....  |   . .|.                                       . . ..  .. |||.  ... | .|| ...   ..... 
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreal

LaQKNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR
   .|| |||||. | .|. |....||.      ....|. .|.. .|. |
e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR
subfamily_PTEN_pd Subfamily PTEN 59-158 4.6e-07 25.0 In-house 64-156 (184) alignment 
Range on Protein: 59-158
Range on HMM: 64-156/184.0
VLNAAEGRSFMHVNTnanfykDSGITYLGIKANDTQEFNLSAYFeraADFIDQALAQKNGRV-LVHCREGYSRSPTLVIAYLMMRQKMDVK-SALSIVRQ
..| . .|.. . .       |. .. .... . . ...| . .    . |.. |.... .|  |||. |  |. .|..|||. ..... . .||..  .
iynlrserkydskkf......dgrvavypfdDhnppplelleei...vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfae

NR
.|
aR
subfamily_Laforin_pd Subfamily Laforin 72-144 1e-06 21.8 In-house 66-137 (183) alignment 
Range on Protein: 72-144
Range on HMM: 66-137/183.0
NTNANFYKDSGITYLGIKANDTQEFNLSAYFERAAdFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQK
.|  ..||. |..|. .  .|    .    . .|  .. .|| .|  .| |||  |  || ..|  .|.   .
itlkklykeeglayiwlptedlstesrvenlpqav.yllhallekghivyvhcnagvgrstaivcgflqyvlg
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 77-148 1.3e-06 18.8 Pfam-A 335-407 (451) alignment 
Range on Protein: 77-148
Range on HMM: 335-407/451.0
FYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQ-KNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVK
  |..    |..... . . .|.. ......||.. |.. || ..||.|..|   | ..|.| | .  . ..|
eekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegk
subfamily_PTPDC1_pd Subfamily PTPDC1 81-158 3.3e-09 31.4 In-house 81-155 (182) alignment 
Range on Protein: 81-158
Range on HMM: 81-155/182.0
SGITYLGIKANDTQEFNLSAYFErAADFIDQALaqKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNR
.||..  .  .| . . |   ..     ...||  ..|.| |||  |  |   |. .||.  .... . |...||..|
qgiyvynfgwkDygvasleriLd.ivkvvafal..qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskr
subfamily_MSG5_pd Subfamily MSG5 83-179 2.7e-11 36.8 In-house 68-162 (165) alignment 
Range on Protein: 83-179
Range on HMM: 68-162/165.0
ITYLGIKANDTQEfnLSAYFERAADFIDQALAQKnGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQ-NREIGPNDGFLAQLCQLNDRLAK
. |  |. . . .  .   . | .  |  | ...  ..||||. | ||| .|..||.|   .. .. |   ..    .| |. |.. || . .  |.|
vkyyhiewehdsk..ivkdlsrltriihaatskr.kkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalsk
subfamily_DSP23_pd Subfamily DSP23 83-158 1.2e-07 26.4 In-house 52-125 (148) alignment 
Range on Protein: 83-158
Range on HMM: 52-125/148.0
ITYLGIKANDTQEFNLSaYFERAADFIDQAlAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNR
.|.  .. .| .   |    ..    ...|  .||  | |||  |. |. |..  ||.  .|.    |.. ||. |
ltlvrlriddyhppale.qvvefvrvveea.eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
0051299 (Phosphotyrosine protein) phosphatases II 92-158 4.8e-12 41.4 In-house 194-265 (288) alignment 
Range on Protein: 92-158
Range on HMM: 194-265/288.0
DTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR
| .  .    . .   ....|||...| |.|||. | .|. |.....|.      ....|| .|.  .|. |
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqR
0047943 (Phosphotyrosine protein) phosphatases II 99-158 2e-12 42.6 In-house 185-251 (273) alignment 
Range on Protein: 99-158
Range on HMM: 185-251/273.0
SAYFERAADFIDQALAQ--KNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR
 ... .  .....||..  .|| |.|||. | .|. |.....|.     .....||..|.  .|. |
lesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqR
0046845 (Phosphotyrosine protein) phosphatases II 100-158 3.2e-12 41.9 In-house 185-253 (284) alignment 
Range on Protein: 100-158
Range on HMM: 185-253/284.0
AYFERAADFIDQALA--QKNGRVLVHCREGYSRSPTLVIAYLMMRQ--------KMDVKSALSIVRQNR
. . .  ......|    ..| ..|||. | .|. |.....|...|        ..|| .|.. .|. |
edlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR
0050432 (Phosphotyrosine protein) phosphatases II 101-158 1.5e-10 36.3 In-house 218-278 (308) alignment 
Range on Protein: 101-158
Range on HMM: 218-278/308.0
YFERAADFIDQALaqKNGRVLVHCREGYSRSPTLVIAYLM-----MRQKMDVKSALSIVRQNR
 . .  ..... |  ..| ..|||. | .|. |.....|.     . ...|| .|.  .|. |
illdflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR
PTPc_DSPc_SM00012 105-153 6.7e-08 28.0 In-house 22-81 (105) alignment 
Range on Protein: 105-153
Range on HMM: 22-81/105.0
AADFIDQALAQK-----NGRVLVHCREGYSRSPTLVIAYLMMRQKMDV------KSALSI
  .....   .|     .. |.|||. | .|. |.| ......| ..       .  .. 
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivke
Y_phosphatase Protein-tyrosine phosphatase 105-158 1.7e-06 23.0 Pfam-A 155-216 (235) alignment 
Range on Protein: 105-158
Range on HMM: 155-216/235.0
AADFIDQALAQK---NGRVLVHCREGYSRSPTLVIAYLMMRQKM-----DVKSALSIVRQNR
  |.|..   .|   .| |.||| .| .|. |.| . ....|       ||..... .|..|
lldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 105-158 1.7e-06 23.0 In-house 155-216 (235) alignment 
Range on Protein: 105-158
Range on HMM: 155-216/235.0
AADFIDQALAQK---NGRVLVHCREGYSRSPTLVIAYLMMRQKM-----DVKSALSIVRQNR
  |.|..   .|   .| |.||| .| .|. |.| . ....|       ||..... .|..|
lldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
subfamily_CDC14_pd Subfamily CDC14 108-167 3.2e-07 24.5 In-house 255-316 (328) alignment 
Range on Protein: 108-167
Range on HMM: 255-316/328.0
FIdQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNR---EIGPNDGFL
|. ... . .| . |||. |  |  ||. .||| . ..  . |.. .|  |    ||| . ||
fl.eiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfl
0048567 (Phosphotyrosine protein) phosphatases II 109-158 3.4e-08 28.0 In-house 66-118 (157) alignment 
Range on Protein: 109-158
Range on HMM: 66-118/157.0
IDQALAQKNGRVLVHCREGY---SRSPTLVIAYLMMRQKMDVKSALSIVRQNR
. . |  ..... |||  |.   .|. ||. .||.......   |. ..|. |
flkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_RNGTT_pd Subfamily RNGTT 114-170 2.7e-10 34.2 In-house 110-167 (189) alignment 
Range on Protein: 114-170
Range on HMM: 110-167/189.0
AQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPND-GFLAQL
 . .  . |||  |. |.  |...||. .....|..|... ...|. |     .|..|
knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkel